CC(C)C[C@](C)(N)COc1ccc(-c2ccnc3ccccc23)cc1C1CC1 CHEMBL4085072 IC50 0.07 nM
CC(C)C[C@](C)(N)COc1ccc(-c2ccnc3ccnn23)cc1C(F)F CHEMBL4544854 IC50 0.2 nM
CC(=O)Nc1cc(-c2ccc(OC[C@@H](N)CC(C)C)c(Cl)c2)ccn1 CHEMBL5186783 IC50 0.2 nM
COC(=O)Nc1cc(-c2ccc(OC[C@@](C)(N)CC(C)C)c(OC(F)(F)F)c2)ccn1 CHEMBL5202896 IC50 0.2 nM
CC(C)C[C@](C)(N)COc1ncc(-c2ccnc3ccccc23)cc1C(F)F CHEMBL4065155 IC50 0.23 nM
CC(=O)Nc1cc(-c2ccc(OC[C@@H](N)CC(C)C)c(C#N)c2)ccn1 CHEMBL4534648 IC50 0.3 nM
COC(=O)Nc1cc(-c2ccc(OC[C@@](C)(N)CC(C)C)c(C(F)(F)F)c2)ccn1 CHEMBL5178261 IC50 0.3 nM
COC(=O)Nc1cc(-c2ccc(OC[C@@](C)(N)CC(C)C)c(C3CC3)c2)ccn1 CHEMBL4084103 IC50 0.32 nM
Cc1cc(-c2ccc(OC[C@@](C)(N)CC(C)C)c(C(F)F)c2)ccn1 CHEMBL5092306 IC50 0.4 nM
CC(C)C[C@](C)(N)COc1ccc(-c2ccnc(C(F)F)c2)cc1C(F)F CHEMBL5088205 IC50 0.4 nM
CC(=O)Nc1cc(-c2ccc(OC[C@@H](N)CC(C)C)c(C(F)(F)F)c2)ccn1 CHEMBL5185616 IC50 0.4 nM
CC(=O)Nc1cc(-c2ccc(OC[C@@H](N)CC(C)C)c(C)c2)ccn1 CHEMBL4062388 IC50 0.4 nM
CC(=O)Nc1cc(-c2ccc(OC[C@@](C)(N)CC(C)C)c(C(F)(F)F)c2)ccn1 CHEMBL5183016 IC50 0.4 nM
COC(=O)Nc1cc(-c2cnc(OC[C@@](C)(N)CC(C)C)c(Cl)c2)ccn1 CHEMBL5188433 IC50 0.4 nM
COC(=O)Nc1cc(-c2cc(C(F)(F)F)c(OC[C@@](C)(N)CC(C)C)cn2)ccn1 CHEMBL5178245 IC50 0.4 nM
COC(=O)Nc1cc(-c2cc(C(F)F)c(OC[C@@](C)(N)CC(C)C)cn2)ccn1 CHEMBL5204210 IC50 0.4 nM
CC(=O)Nc1cc(-c2ccc(OC[C@@H](N)CC(C)C)c(OC(F)(F)F)c2)ccn1 CHEMBL5179172 IC50 0.45 nM
COC(=O)Nc1cc(-c2ccc(OC[C@@](C)(N)CC(C)C)c(C#N)c2)ccn1 CHEMBL5174967 IC50 0.5 nM
COC(=O)Nc1cc(-c2ccc(OC[C@@](C)(N)CC(C)C)c(C(F)F)c2)ccn1 CHEMBL5202370 IC50 0.5 nM
COC(=O)Nc1cc(-c2ccc(OC[C@@](C)(N)CC(C)C)c(Cl)c2)ccn1 CHEMBL5187778 IC50 0.5 nM
COC(=O)Nc1cc(-c2ccc(OC[C@@](C)(N)CC(C)C)c(Cl)n2)ccn1 CHEMBL5205578 IC50 0.5 nM
Cc1cc(-c2cc(C(F)F)c(OC[C@@](C)(N)CC(C)C)cn2)ccn1 CHEMBL4092824 IC50 0.5 nM
CC(=O)Nc1cc(-c2ccc(OC[C@@](C)(N)CC(C)C)c(C(F)F)c2)ccn1 CHEMBL5204340 IC50 0.5 nM
CC(C)C[C@](C)(N)COc1cnc(-c2ccnc(C(F)F)c2)cc1C(F)F CHEMBL5199698 IC50 0.5 nM
CC(C)C[C@](C)(N)COc1ccc(-c2ccncc2)cc1C(F)(F)F CHEMBL5074777 IC50 0.6 nM
CC(C)C[C@](C)(N)COc1ccc(-c2ccnc(C(F)F)c2)cc1C(F)(F)F CHEMBL5082933 IC50 0.6 nM
CC(C)C[C@](C)(N)COc1ccc(-c2ccnc(C(F)F)c2)cc1C#N CHEMBL5084823 IC50 0.6 nM
CC(=O)Nc1cc(-c2ccc(OC[C@@](C)(N)CC(C)C)c(C#N)c2)ccn1 CHEMBL5189920 IC50 0.6 nM
Cc1nccc2c1c(=O)n(C)c1cc(OC[C@@H](N)CC(C)C)c(C#N)cc21 CHEMBL4857123 IC50 0.6 nM
CCOC(=O)Nc1cc2c(cn1)OCc1cc(OC[C@@](C)(N)CC(C)C)ccc1-2 CHEMBL4559183 IC50 0.62 nM
CC(C)C[C@](C)(N)COc1ccc(-c2ccnc(C(F)F)c2)cc1C1CC1 CHEMBL5093649 IC50 0.7 nM
Cc1cc(-c2ccc(OC[C@@H](N)CC(C)C)c(C#N)c2)ccn1 CHEMBL5085177 IC50 0.8 nM
COC(=O)Nc1cc(-c2ccc(OC[C@@H](N)CC(C)C)c(-c3ccno3)c2)ccn1 CHEMBL5179243 IC50 0.8 nM
CC(=O)Nc1cc(-c2ccc(OC[C@@](C)(N)CC(C)C)c(OC(F)(F)F)c2)ccn1 CHEMBL5177574 IC50 0.8 nM
CC(=O)Nc1cc(-c2ccc(OC[C@@](C)(N)CC(C)C)c(F)c2)ccn1 CHEMBL5189987 IC50 0.8 nM
COC(=O)Nc1cc(-c2ccc(OC[C@@](C)(N)CC(C)C)c(C)c2)ccn1 CHEMBL5198877 IC50 0.8 nM
COC(=O)Nc1cc(-c2ccc(OC[C@@](C)(N)CC(C)C)c(C(F)F)n2)ccn1 CHEMBL5202142 IC50 0.8 nM
CC(C)C[C@](C)(N)COc1cnc(-c2ccnc(Cl)c2)cc1C(F)F CHEMBL5194667 IC50 0.8 nM
Cc1cc(-c2ccc(OC[C@@](C)(N)CC(C)C)c(C(F)(F)F)c2)ccn1 CHEMBL5069779 IC50 0.9 nM
COC(=O)Nc1cc(-c2cnc(OC[C@@](C)(N)CC(C)C)c(C)c2)ccn1 CHEMBL5184381 IC50 0.9 nM
CC(=O)Nc1cc2c(cn1)COc1cc(OC[C@@](C)(N)CC(C)C)ccc1-2 CHEMBL5431686 IC50 0.9 nM
CCS(=O)(=O)N1CCN(c2ccc(Nc3ncc(C(N)=O)c(NC4CC4)n3)cc2)CC1 CHEMBL3991929 Kd apparent 1.0 nM
COc1ccccc1-c1cnc2ccc(N3CC[C@H](N(C)C(=O)C(C)(C)C)C3)nn12 CHEMBL5200929 Kd 1.0 nM
COc1ccccc1-c1cnc2ccc(N3CC[C@H](N(C)C(=O)C(C)C)C3)nn12 CHEMBL5184366 Kd 1.0 nM
COC(=O)Nc1cc(-c2cnc(OC[C@@](C)(N)CC(C)C)c(C#N)c2)ccn1 CHEMBL5185000 IC50 1.0 nM
COc1ncccc1-c1cnc2ccc(N3CC[C@@H](N(C)C(=O)OC(C)(C)C)C3)nn12 CHEMBL5410925 Kd 1.0 nM
COc1ncccc1-c1cnc2ccc(N3CC[C@@H](N(C)C(=O)OC(C)C)C3)nn12 CHEMBL5403382 Kd 1.0 nM
COC(=O)Nc1cc(-c2ccc(OC[C@@](C)(N)CC(C)C)c(F)c2)ccn1 CHEMBL5177318 IC50 1.1 nM
COC(=O)Nc1cc(-c2ccc(OC[C@@](C)(N)CC(C)C)c(C)n2)ccn1 CHEMBL5170576 IC50 1.1 nM
COC(=O)Nc1cc(-c2cc(Cl)c(OC[C@@](C)(N)CC(C)C)cn2)ccn1 CHEMBL5177255 IC50 1.1 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL388978 Kd 1.2 nM
COC(=O)Nc1cc(-c2ccc(OC[C@@H](N)CC(C)C)c(F)c2)ccn1 CHEMBL5205319 IC50 1.2 nM
Cc1cc(-c2cc(C(F)(F)F)c(OC[C@@](C)(N)CC(C)C)cn2)ccn1 CHEMBL5177360 IC50 1.2 nM
CC(=O)Nc1cc(-c2cc(F)c(OC[C@@H](N)CC(C)C)cc2F)ccn1 CHEMBL5189450 IC50 1.3 nM
Cc1cc(-c2ccnc(C(F)F)c2)ncc1OC[C@@](C)(N)CC(C)C CHEMBL5194195 IC50 1.4 nM
CC(C)C[C@](C)(N)COc1ccc(-c2ccnc(C(F)F)c2)nc1Cl CHEMBL5084438 IC50 1.5 nM
CC(=O)Nc1cc(-c2ccc(OC[C@@H](N)CC(C)C)c(F)c2)ccn1 CHEMBL5198578 IC50 1.6 nM
COC(=O)Nc1cc(-c2cc(C)c(OC[C@@](C)(N)CC(C)C)cn2)ccn1 CHEMBL5195653 IC50 1.7 nM
Cc1cc(-c2cnc(OC[C@@](C)(N)CC(C)C)c(C(F)F)c2)ccn1 CHEMBL5082893 IC50 1.9 nM
Cc1cc(-c2cc(Cl)c(OC[C@@](C)(N)CC(C)C)cn2)ccn1 CHEMBL5204513 IC50 1.9 nM
Cn1cc(C2=Nc3cc(NC(=O)C(N)C4CCCCC4)cc4c3C2=CNNC4=O)cn1 CHEMBL3545137 Kd apparent 2.0 nM
CC(C)C[C@](C)(N)COc1ccc(-c2ccnc(C(F)F)c2)nc1C(F)F CHEMBL5089410 IC50 2.0 nM
CC(C)C[C@](C)(N)COc1ccc(-c2ccnc(F)c2)cc1C(F)(F)F CHEMBL5086617 IC50 2.2 nM
Cc1cc(-c2ccc(OC[C@@](C)(N)CC(C)C)c(C3CC3)c2)ccn1 CHEMBL5088856 IC50 2.3 nM
CC(C)C[C@](C)(N)COc1cnc(-c2ccnc(Cl)c2)cc1Cl CHEMBL5175327 IC50 2.3 nM
Cc1cc(-c2ccnc(C(F)F)c2)cnc1OC[C@@](C)(N)CC(C)C CHEMBL5074638 IC50 2.5 nM
[3H]CC([3H])(C[3H])C([3H])[C@H](N)COc1ccc2c(c1)[nH]c(=O)c1cnccc12 CHEMBL5426721 IC50 2.8 nM
COc1ncccc1-c1cnn2ccc(N3CCN(C(=O)OC(C)C)CC3)nc12 CHEMBL4127773 IC50 2.8 nM
Cc1cc(-c2ccc(OC[C@@](C)(N)CC(C)C)c(C(F)F)n2)ccn1 CHEMBL5084977 IC50 2.9 nM
COc1cc(-c2ccnc(NC(C)=O)c2)ccc1OC[C@@H](N)CC(C)C CHEMBL4073745 IC50 3.0 nM
C[C@]12O[C@H](C[C@]1(O)CO)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)CNC4=O CHEMBL603469 Kd 3.1 nM
CC(C)C[C@](C)(N)COc1ncc(-c2ccnc(Cl)c2)cc1C(F)F CHEMBL5080544 IC50 3.1 nM
CC(C)C[C@](C)(N)COc1ncc(-c2ccnc(C(F)F)c2)cc1C#N CHEMBL5078653 IC50 3.1 nM
CC(C)n1nnc(-c2cc(O)cc(Nc3ncnn4ccc(CN5CCC(N)CC5)c34)c2)n1 CHEMBL4541595 IC50 3.3 nM
COC(=O)Nc1cc(-c2cc(OC)c(OC[C@@](C)(N)CC(C)C)cn2)ccn1 CHEMBL5175427 IC50 3.5 nM
COC(=O)Nc1cc(-c2cnc(OC[C@@](C)(N)CC(C)C)c(OC)c2)ccn1 CHEMBL5171363 IC50 3.8 nM
CC(C)C[C@](C)(N)COc1ccc(-c2ccnc(Cl)c2)nc1C(F)F CHEMBL5085681 IC50 3.9 nM
COC(=O)Nc1cc(-c2ccc(OC[C@@](C)(N)CC(C)C)c(CO)c2)ccn1 CHEMBL5195859 IC50 3.9 nM
N#CCNC(=O)c1ccc(-c2ccnc(Nc3ccc(N4CCOCC4)cc3)n2)cc1 CHEMBL1078178 Kd apparent 4.0 nM
CC(C)C[C@@H](N)c1nc2cc(-c3ncnc4[nH]ccc34)ccc2[nH]1 CHEMBL4525214 IC50 4.0 nM
COc1ccc(-c2cnc3[nH]cc(C#Cc4cccnc4)c3c2)cc1OC CHEMBL4439128 IC50 4.0 nM
CC(C)C[C@H](N)c1cc(C#N)c2cc(-c3cnco3)ccc2n1 CHEMBL5194899 IC50 4.2 nM
COc1ccc(-c2cnc3[nH]cc(NC(=O)c4cccnc4)c3c2)cc1OC CHEMBL4541962 IC50 4.32 nM
COC(=O)Nc1cc(-c2ccc(OC[C@@](C)(N)CC(C)C)c(C)c2C)ccn1 CHEMBL5180992 IC50 4.5 nM
Cc1cc(-c2ccc(OC[C@@](C)(N)CC(C)C)c(C#N)c2)ccn1 CHEMBL5085230 IC50 4.6 nM
CC(=O)Nc1cc(-c2ccc(OC[C@@H](N)CC(C)C)cc2)ccn1 CHEMBL5193012 IC50 4.6 nM
CN(CCNc1ccc2ncc(-c3ccc(C(N)=O)cc3)n2n1)C(=O)OC(C)(C)C CHEMBL4855590 IC50 4.8 nM
CC(=O)Nc1cc(-c2cc(F)c(OC[C@@H](N)CC(C)C)c(C(F)(F)F)c2)ccn1 CHEMBL5172656 IC50 4.8 nM
COC(=O)[C@@]1(O)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL281948 Kd apparent 5.0 nM
CO[C@@H]1[C@H](N(C)CCOCCOCCOCCNC(=O)CCC2=[N+]3C(=Cc4c(C)cc(C)n4[B-]3(F)F)C=C2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL4576489 Kd 5.0 nM
CC(C)C[C@H](N)c1cc(C#N)c2cc(-c3ccncc3)ccc2n1 CHEMBL5202351 IC50 5.8 nM
Cc1nc(N)sc1-c1ccnc(Nc2ccc(N3CCOCC3)cc2)n1 CHEMBL482967 Kd apparent 6.0 nM
O=C(Nc1ccc(-c2ccnc(Nc3ccc(N4CCOCC4)cc3)n2)cc1)C1CCCN1 CHEMBL3545328 Kd apparent 6.0 nM
COc1cc2nc(C(N)CC(C)C)nc(C#N)c2cc1-c1cnco1 CHEMBL4543869 IC50 6.0 nM
CO[C@@H]1[C@H](NCCOCCOCCOCCNC(=O)CCC2=[N+]3C(=Cc4c(C)cc(C)n4[B-]3(F)F)C=C2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL4465866 Kd 6.0 nM
CC(C)CS(=O)(=O)Nc1cccc(-c2ccc3c(NC(=O)C4CC4)n[nH]c3c2)c1 CHEMBL4571548 Ki 6.2 nM
O=C(Nc1n[nH]c2cc(-c3cccc(NS(=O)(=O)CC4CC4)c3)ccc12)C1CC1 CHEMBL4534959 Ki 6.3 nM
CC(=O)Nc1cc(-c2cc(F)c(OC[C@@H](N)CC(C)C)c(Cl)c2)ccn1 CHEMBL5191442 IC50 6.8 nM
CC(C)CC(N)c1cc(C#N)c2cc(-c3ccncc3)ccc2n1 CHEMBL5195909 IC50 7.3 nM
Cc1cc(-c2ccnc(Cl)c2)cnc1OC[C@@](C)(N)CC(C)C CHEMBL5088767 IC50 7.6 nM
CCN(C)S(=O)(=O)Nc1cccc(-c2ccc3c(NC(=O)C4CC4)n[nH]c3c2)c1 CHEMBL4531680 Ki 8.2 nM
CCS(=O)(=O)N1CC(CC#N)(n2cc(-c3ncnc4[nH]ccc34)cn2)C1 CHEMBL2105759 Kd 8.2 nM
O=C(Nc1n[nH]c2cc(-c3cccc(NS(=O)(=O)C4CC4)c3)ccc12)C1CC1 CHEMBL4516665 Ki 8.3 nM
O=C(Nc1n[nH]c2cc(-c3cccc(NS(=O)(=O)C4CCC4)c3)ccc12)C1CC1 CHEMBL4535040 Ki 8.5 nM
CC(=O)NCC(=O)N1C2CCC1c1cc(Nc3ncc(C(F)(F)F)c(NC4CCC4)n3)ccc12 CHEMBL1983111 Kd apparent 9.0 nM
CCN(CC)S(=O)(=O)Nc1cccc(-c2ccc3c(NC(=O)C4CC4)n[nH]c3c2)c1 CHEMBL4452939 Ki 9.1 nM
COc1ccc(-c2cnc3[nH]cc(C#Cc4cccnc4)c3n2)cc1OC CHEMBL4442812 IC50 9.27 nM
CN(C)S(=O)(=O)Nc1cccc(-c2ccc3c(NC(=O)C4CC4)n[nH]c3c2)c1 CHEMBL4452360 Ki 10.0 nM
COc1cc(NC(=O)[C@@H]2NCCC[C@@H]2C(C)C)ccc1-c1cnco1 CHEMBL4871177 IC50 10.0 nM
COc1cc(-c2ccc(OC[C@@H](N)CC(C)C)c(C#N)c2)ccn1 CHEMBL5089204 IC50 10.0 nM
CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C CHEMBL535 Kd 11.0 nM
CC(C)C[C@@H](N)c1cc(C#N)c2cc(-c3ccncc3)ccc2n1 CHEMBL5182431 IC50 11.0 nM
O=c1[nH]ccc2cc(OC3CCNCC3)ccc12 CHEMBL1667969 Kd apparent 12.0 nM
CCCS(=O)(=O)Nc1cccc(-c2ccc3c(NC(=O)C4CC4)n[nH]c3c2)c1 CHEMBL4552310 Ki 12.0 nM
COc1cc(NC(=O)[C@H](N)CC(C)C)ccc1-c1cnco1 CHEMBL4877371 IC50 12.0 nM
CC(C)C[C@@H](N)C(=O)Nc1ccc(-c2cnco2)c(OC(F)F)c1 CHEMBL4872886 IC50 12.0 nM
CCc1nc([C@@H](N)CC(C)C)nc2cc(OC)c(-c3cnco3)cc12 CHEMBL5201888 IC50 12.0 nM
COc1cc(NC(=O)[C@H](N)C2CCCC2)ccc1-c1cnco1 CHEMBL4850768 IC50 13.0 nM
CCOc1cc(NC(=O)[C@H](N)CC(C)C)ccc1-c1cnco1 CHEMBL4877595 IC50 13.0 nM
COc1cc(NC(=O)[C@H](N)CC(C)C)ccc1-c1cn[nH]c1 CHEMBL4867649 IC50 15.0 nM
CC(C)C[C@@H](N)C(=O)Nc1ccc(-c2ccncc2)cc1 CHEMBL4877470 IC50 15.0 nM
CC(C)CC(N)c1nc(C#N)c2cc(-c3ccncc3)ccc2n1 CHEMBL5205801 IC50 16.0 nM
O=C(Nc1c[nH]c2ncc(-c3ccsc3)cc12)c1cccnc1 CHEMBL4456500 Kd 16.1 nM
O=C(Nc1c[nH]nc1-c1nc2ccc(CN3CCOCC3)cc2[nH]1)NC1CC1 CHEMBL495727 Kd apparent 17.0 nM
CC(C)C1CCCNC1C(=O)Nc1ccc(-c2ccncc2)cc1 CHEMBL4845935 IC50 17.0 nM
CC(C)CC(N)c1nc(C#N)c2cc(-c3cnco3)ccc2n1 CHEMBL5175828 IC50 17.0 nM
COc1cc(NC(=O)[C@H](N)C2CCCCC2)ccc1-c1cnco1 CHEMBL4874269 IC50 18.0 nM
Cc1cccc(-c2cnc3[nH]cc(NC(=O)c4cccnc4)c3c2)c1 CHEMBL4483684 IC50 18.6 nM
COc1cc(NC(=O)[C@@H](N)CC(C)C)ccc1-c1cnco1 CHEMBL4870589 IC50 19.0 nM
Cc1cc(-c2ccc(OC[C@@](C)(N)CC(C)C)c(Cl)n2)ccn1 CHEMBL5085373 IC50 19.0 nM
Cc1cc(-c2cc(C)c(OC[C@@](C)(N)CC(C)C)cn2)ccn1 CHEMBL5180606 IC50 19.0 nM
COc1ccc(-c2cnc3[nH]cc(NC(=O)c4cccnc4)c3c2)cc1 CHEMBL4450261 Kd 19.4 nM
CCN(C)S(=O)(=O)NCc1cccc(-c2ccc3c(NC(=O)C4CC4)n[nH]c3c2)c1 CHEMBL4470026 Ki 20.0 nM
CC(C)CC(N)c1ccc2cc(-c3ccncc3)ccc2n1 CHEMBL5207636 IC50 21.0 nM
CC(C)C[C@H](N)COc1ccc(-c2ccnc(N)c2)cc1 CHEMBL5193138 IC50 21.0 nM
COCCN1CCN(Cc2ccc(-c3n[nH]c4c3C(=O)c3c(NC(=O)NN5CCOCC5)cccc3-4)cc2)CC1 CHEMBL3545083 Kd apparent 22.0 nM
O=C(Nc1n[nH]c2cc(-c3cccc(NS(=O)(=O)Cc4ccccc4F)c3)ccc12)C1CC1 CHEMBL4473140 Ki 22.0 nM
O=C(Nc1n[nH]c2cc(-c3cccc(CNS(=O)(=O)CC4CC4)c3)ccc12)C1CC1 CHEMBL4542463 Ki 22.0 nM
Cc1cc(-c2cnc(OC[C@@](C)(N)CC(C)C)c(C#N)c2)ccn1 CHEMBL5078891 IC50 22.0 nM
CC(C)C[C@@H](N)c1cc(C#N)c2cc(-c3cnco3)ccc2n1 CHEMBL5204563 IC50 22.0 nM
COC(=O)Nc1cc(-c2ccc(OC[C@@](C)(N)CC(C)C)cn2)ccn1 CHEMBL5169857 IC50 23.0 nM
COc1ccc(-c2cnc3[nH]cc(-c4ccccc4)c3c2)cc1OC CHEMBL3102941 IC50 23.6 nM
O=C(Nc1n[nH]c2cc(-c3cccc(NS(=O)(=O)Cc4cccc(F)c4)c3)ccc12)C1CC1 CHEMBL4593649 Ki 24.0 nM
CCc1nc(C(N)CC(C)C)nc2cc(OC)c(-c3cnco3)cc12 CHEMBL5170931 IC50 24.0 nM
CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)c(OC)c2)nc1NC1CCOCC1 CHEMBL3301622 Kd apparent 25.0 nM
COC(=O)Nc1cc(-c2ccc(OC[C@@](C)(N)CC(C)C)nc2)ccn1 CHEMBL5198829 IC50 28.0 nM
CC(C)CS(=O)(=O)NCc1cccc(-c2ccc3c(NC(=O)C4CC4)n[nH]c3c2)c1 CHEMBL4522276 Ki 30.0 nM
Cc1cc(-c2cnc(OC[C@@](C)(N)CC(C)C)c(Cl)c2)ccn1 CHEMBL5077192 IC50 30.0 nM
CCc1nc([C@@H](N)CC(C)C)nc2ccc(-c3cnco3)cc12 CHEMBL5208293 IC50 30.0 nM
CC[C@@H](C)[C@@H](N)C(=O)Nc1ccc(-c2cnco2)c(OC)c1 CHEMBL4857865 IC50 31.0 nM
O=C(Nc1n[nH]c2cc(-c3cccc(CNS(=O)(=O)CCC(F)(F)F)c3)ccc12)C1CC1 CHEMBL4447403 Ki 32.0 nM
Cc1cnc(Nc2ccc(OCCN3CCCC3)cc2)nc1Nc1cccc(S(=O)(=O)NC(C)(C)C)c1 CHEMBL1287853 IC50 32.0 nM
CCN(CC)S(=O)(=O)NCc1cccc(-c2ccc3c(NC(=O)C4CC4)n[nH]c3c2)c1 CHEMBL4472438 Ki 33.0 nM
COc1cc(NC(=O)[C@H](N)CC2CCC2)ccc1-c1cnco1 CHEMBL4876045 IC50 33.0 nM
Oc1c2ccccc2c2c3c(cccc13)N=N2 CHEMBL1725279 Kd 35.0 nM
O=C1NC(=O)/C(=C/c2ccc3nccc(-c4ccncc4)c3c2)S1 CHEMBL3544966 Kd apparent 35.0 nM
Cc1cc(-c2ccc(OC[C@@](C)(N)CC(C)C)c(C)n2)ccn1 CHEMBL5088528 IC50 36.0 nM
NC(=O)Nc1cc(-c2cccc(F)c2)sc1C(=O)N[C@H]1CCCNC1 CHEMBL2041933 Kd 36.5 nM
O=C(Nc1n[nH]c2cc(-c3cccc(CNS(=O)(=O)CC(F)(F)F)c3)ccc12)C1CC1 CHEMBL4582326 Ki 39.0 nM
C1=N/C2=N/c3ccc(OCCN4CCCC4)c(c3)COC/C=C/COCc3cccc(c3)C(=C1)N2 CHEMBL2035187 Kd apparent 42.0 nM
COc1cc(NC(=O)[C@H](N)c2ccccc2)ccc1-c1cnco1 CHEMBL4850319 IC50 42.0 nM
Cc1n[nH]c2ccc(-c3cncc(OC[C@@H](N)Cc4ccccc4)c3)cc12 CHEMBL379218 Kd 43.0 nM
CC(C)C[C@@H](N)C(=O)Nc1ccc(-c2cnco2)c(F)c1 CHEMBL4845745 IC50 43.0 nM
CN(CC(F)(F)F)S(=O)(=O)NCc1cccc(-c2ccc3c(NC(=O)C4CC4)n[nH]c3c2)c1 CHEMBL4561238 Ki 44.0 nM
CCc1nc(C(N)CC(C)C)nc2ccc(-c3ccncc3)cc12 CHEMBL5200458 IC50 44.0 nM
COc1cc(NC(=O)[C@H](N)CC2CC2)ccc1-c1cnco1 CHEMBL4873626 IC50 45.0 nM
CN[C@H](CC(C)C)C(=O)Nc1ccc(-c2cnco2)c(OC)c1 CHEMBL4860340 IC50 46.0 nM
CO[C@@H]1[C@H](N(C)C(=O)c2ccccc2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL608533 Kd 48.0 nM
O=C(c1ccc(/C=C/c2n[nH]c3ccccc23)cc1)N1CCNCC1 CHEMBL1908397 Kd 48.0 nM
Cc1cc(NC(=O)[C@H](N)CC(C)C)ccc1-c1cnco1 CHEMBL4864738 IC50 48.0 nM
CC(C)C[C@H](N)COc1ccc(-c2ccncc2)cc1 CHEMBL5079068 IC50 48.0 nM
COc1cc(NC(=O)[C@H](N)CC(C)C)ccc1-c1cn[nH]n1 CHEMBL4854816 IC50 49.0 nM
CC(C)C[C@H](N)COc1ccc(-c2ccnc(C(F)(F)F)c2)cc1C#N CHEMBL5079451 IC50 51.0 nM
N#Cc1ccc(-c2cnc3[nH]cc(NC(=O)c4cccnc4)c3c2)cc1 CHEMBL516312 Kd 53.0 nM
Cc1ccc(-c2cnc3[nH]cc(NC(=O)c4cccnc4)c3c2)cc1 CHEMBL4455428 Kd 53.2 nM
CC(C)S(=O)(=O)Nc1cccc(-c2ccc3c(NC(=O)C4CC4)n[nH]c3c2)c1 CHEMBL4452093 IC50 54.0 nM
O=C(Nc1n[nH]c2cc(-c3cccc(NS(=O)(=O)Cc4ccc(F)cc4)c3)ccc12)C1CC1 CHEMBL4534571 Ki 59.0 nM
COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(N(C)C(=O)CN2CCN(C)CC2)cc1)c1ccccc1 CHEMBL502835 Kd 63.0 nM
CCCC[C@@H](N)C(=O)Nc1ccc(-c2cnco2)c(OC)c1 CHEMBL4853175 IC50 65.0 nM
Cc1[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c(C)c1C(=O)NC[C@H](O)CN1CCOCC1 CHEMBL1721885 Kd 66.0 nM
CCc1nc(C(N)CC(C)C)nc2ccc(-c3cnco3)cc12 CHEMBL5182634 IC50 67.0 nM
COc1cc(NC(=O)[C@H](N)C(C)C)ccc1-c1cnco1 CHEMBL4873273 IC50 69.0 nM
CS(=O)(=O)NCc1cccc(-c2ccc3c(NC(=O)C4CC4)n[nH]c3c2)c1 CHEMBL4590146 IC50 71.0 nM
COc1cc(NC(=O)[C@H](N)CCC(C)C)ccc1-c1cnco1 CHEMBL4857148 IC50 71.0 nM
CC(C)C[C@@H](N)C(=O)Nc1ccc(-c2cnco2)c(C#N)c1 CHEMBL4855163 IC50 72.0 nM
COc1ccc(C(=O)Nc2c[nH]c3ncc(-c4ccc(OC)c(OC)c4)cc23)cc1 CHEMBL4443908 IC50 72.1 nM
NS(=O)(=O)c1ccc(CNc2nc(Nc3cccc(NC(=O)N4CCCC4)c3)ncc2Br)cc1 CHEMBL5079149 IC50 74.0 nM
COc1cc(NC(=O)CCC(C)C)ccc1-c1cnco1 CHEMBL4875431 IC50 80.0 nM
COc1cc(NC(=O)CC2CCCC2)ccc1-c1cnco1 CHEMBL4854187 IC50 80.0 nM
NS(=O)(=O)c1ccc(CNc2nc(Nc3cccc(CN4CCOCC4)c3)ncc2Br)cc1 CHEMBL5083125 IC50 80.0 nM
O=C(Nc1c[nH]c2ncc(-c3ccccc3)cc12)c1cccnc1 CHEMBL4590585 Kd 82.2 nM
COc1cc(NC(=O)C(CN)CC(C)C)ccc1-c1cnco1 CHEMBL4872087 IC50 83.0 nM
COc1cc(NC(=O)[C@H](N)CC(C)(C)C)ccc1-c1cnco1 CHEMBL4868996 IC50 85.0 nM
COc1cc(NC(=O)[C@H](N)CC(C)C)ccc1-c1ccncc1 CHEMBL4870048 IC50 85.0 nM
CCC[C@@H](N)C(=O)Nc1ccc(-c2cnco2)c(OC)c1 CHEMBL4865219 IC50 90.0 nM
CCc1nc([C@H](N)CC(C)C)nc2cc(OC)c(-c3cnco3)cc12 CHEMBL5204415 IC50 95.0 nM
CCc1cc(NC(=O)[C@H](N)CC(C)C)ccc1-c1cnco1 CHEMBL4846012 IC50 100.0 nM
N#CC[C@H](C1CCCC1)n1cc(-c2ncnc3[nH]ccc23)cn1 CHEMBL1789941 IC50 100.0 nM
CCN1CCN(Cc2ccc(Nc3ncc(F)c(-c4cc(F)c5nc(C)n(C(C)C)c5c4)n3)nc2)CC1 CHEMBL3301610 Kd apparent 102.0 nM
COC[C@@H](CC(C)C)NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5426285 IC50 106.0 nM
COc1ccc(-c2cnc3[nH]cc(NC(=O)c4ccccc4)c3c2)cc1OC CHEMBL4444527 IC50 108.0 nM
COc1cc(NC(=O)[C@H](N)CC(C)C)ccc1-c1ccnnc1 CHEMBL4865565 IC50 110.0 nM
CC(C)C[C@@H](N)COc1ccc(-c2ccncc2)cc1 CHEMBL5081027 IC50 110.0 nM
COc1cc2nc(C(N)CC(C)C)ncc2cc1-c1cnco1 CHEMBL5174061 IC50 110.0 nM
CN(c1cccc(-c2ccc3c(NC(=O)C4CC4)n[nH]c3c2)c1)S(C)(=O)=O CHEMBL4587030 IC50 120.0 nM
CC[C@@H](N)C(=O)Nc1ccc(-c2cnco2)c(OC)c1 CHEMBL4873120 IC50 120.0 nM
C[C@@H](N)c1ccc(C(=O)Nc2ccnc3[nH]ccc23)cc1 CHEMBL571948 Kd apparent 122.0 nM
COc1cc(NC(=O)C[C@@H](N)C(C)C)ccc1-c1cnco1 CHEMBL4871299 IC50 127.0 nM
CC(C)C[C@H](N)COc1ccc(-c2ccnc(NCc3ccccc3)c2)cc1 CHEMBL5171457 IC50 127.0 nM
CC(C)c1cc(CNc2nc(Nc3cc(C4CC4)[nH]n3)cc(N3CCN(C)CC3)n2)on1 CHEMBL3545085 Kd apparent 138.0 nM
O=C(Nc1c[nH]c2ncc(-c3ccc(F)cc3)cc12)c1cccnc1 CHEMBL4453393 Kd 141.0 nM
COc1cccc(C#Cc2c[nH]c3ncc(-c4ccc(OC)c(OC)c4)cc23)c1 CHEMBL4454007 IC50 149.0 nM
COc1cc(NC(=O)[C@H](N)CC(C)C)ccc1-c1ccnc(N)c1 CHEMBL4877312 IC50 150.0 nM
CC(C)C[C@@H](N)C(=O)Nc1ccc(-c2cnco2)c(OC(F)(F)F)c1 CHEMBL4871551 IC50 160.0 nM
COc1ccc(-c2cnc3[nH]cc(NC(=O)c4ccc(F)cc4)c3c2)cc1OC CHEMBL4524476 IC50 161.0 nM
CN1CCN(c2ccc3nc(-c4c(N)c5c(F)cccc5[nH]c4=O)[nH]c3c2)CC1 CHEMBL522892 Kd 170.0 nM
CC(C)C[C@@H](N)C(=O)Nc1ccc(-c2cnco2)cc1 CHEMBL4862414 IC50 170.0 nM
Cc1nc(C(N)CC(C)C)nc2ccc(-c3cnco3)cc12 CHEMBL5184309 IC50 170.0 nM
CC(=O)c1cnc2ccc(-c3cc(Cl)c(O)c(Cl)c3)nc2c1N[C@H]1CC[C@H](CN(C)C)CC1 CHEMBL3688339 Kd apparent 172.0 nM
COc1ccc(-c2cnc3[nH]cc(C(=O)c4ccccc4)c3c2)cc1OC CHEMBL4474078 IC50 184.0 nM
CCC(F)(F)c1cc(N2CCC(S(C)(=O)=O)CC2)nc2sc(C(N)=O)c(N)c12 CHEMBL4522930 IC50 188.0 nM
COc1cc(NC(=O)[C@H](N)CC(C)C)ccc1-c1cncs1 CHEMBL4875628 IC50 190.0 nM
Nc1nc(Nc2ccc(S(N)(=O)=O)cc2)nn1C(=O)c1c(F)cccc1F CHEMBL191003 Kd 200.0 nM
CC1CN(c2ccncc2NC(=O)c2ccnn3cc(-c4ccccc4)nc23)CCO1 CHEMBL5270781 IC50 200.0 nM
COc1ccc(-c2cnc3[nH]cc(C#Cc4ccccc4)c3c2)cc1OC CHEMBL4461527 IC50 209.0 nM
CNc1nc(C(N)CC(C)C)nc2ccc(-c3cnco3)cc12 CHEMBL5209199 IC50 210.0 nM
CS(=O)(=O)Nc1cccc(-c2ccc3c(NC(=O)C4CC4)n[nH]c3c2)c1 CHEMBL103080 IC50 220.0 nM
CCc1nc([C@H](N)CC(C)C)nc2ccc(-c3cnco3)cc12 CHEMBL5177481 IC50 220.0 nM
Cc1ncc(-c2ccnc(Nc3ccc(S(C)(=O)=O)cc3)n2)n1C(C)C CHEMBL488436 Kd apparent 228.0 nM
O=C(Nc1c[nH]c2ncc(-c3ccc(C(F)(F)F)cc3)cc12)c1cccnc1 CHEMBL4561278 IC50 230.0 nM
COc1nc(C(N)CC(C)C)nc2ccc(-c3cnco3)cc12 CHEMBL5193040 IC50 230.0 nM
COc1cc(NC(=O)[C@H](N)CC(C)C)ccc1-c1ccnc(Cl)c1 CHEMBL4856974 IC50 240.0 nM
CCCC[C@H](N)C(=O)Nc1ccc(-c2cnco2)c(OC)c1 CHEMBL4860241 IC50 260.0 nM
O=C(Nc1n[nH]c2cc(-c3ccc(O)cc3)ccc12)C1CC1 CHEMBL260163 IC50 280.0 nM
Cc1cc(Nc2cc(N3CCN(C)CC3)nc(Sc3ccc(NC(=O)C4CC4)cc3)n2)n[nH]1 CHEMBL572878 Kd 290.0 nM
COc1cc(NC(=O)[C@H](N)CC(C)C)ccc1-c1ccncn1 CHEMBL4855972 IC50 290.0 nM
COc1ccc(-c2cnc3[nH]cc(NC(=O)C4CCCCC4)c3c2)cc1OC CHEMBL3334981 IC50 319.0 nM
Cc1[nH]c(/C=C2\C(=O)Nc3ccc(S(=O)(=O)Cc4c(Cl)cccc4Cl)cc32)c(C)c1C(=O)N1CCC[C@@H]1CN1CCCC1 CHEMBL450786 Kd 320.0 nM
CCOc1nc(C(N)CC(C)C)nc2ccc(-c3cnco3)cc12 CHEMBL5176849 IC50 340.0 nM
O=C(Nc1n[nH]c2cc(-c3cccc(O)c3)ccc12)C1CC1 CHEMBL4094782 IC50 350.0 nM
CCC[C@H](N)C(=O)Nc1ccc(-c2cnco2)c(OC)c1 CHEMBL4856131 IC50 350.0 nM
COc1cc(NC(=O)[C@H]2NCCC[C@H]2C(C)C)ccc1-c1cnco1 CHEMBL4869558 IC50 360.0 nM
CC(C)CC(N)c1nc(N(C)C)c2cc(-c3cnco3)ccc2n1 CHEMBL5171538 IC50 360.0 nM
COc1c(-c2cnco2)ccc2nc(C(N)CC(C)C)ncc12 CHEMBL5208680 IC50 360.0 nM
O=C(Nc1n[nH]c2cc(-c3cccc(NS(=O)(=O)C4CC4)c3)ccc12)C1CCC1 CHEMBL4472562 IC50 370.0 nM
COc1ccc(-c2cnc3[nH]cc(NC(=O)c4ccncc4)c3c2)cc1OC CHEMBL4515873 IC50 381.0 nM
COc1ccc(-c2cnc3[nH]cc(C#Cc4cccc(C#N)c4)c3c2)cc1OC CHEMBL4448513 IC50 381.0 nM
COc1ccc(-c2cnc3[nH]cc(C#Cc4ccc(F)cc4)c3c2)cc1OC CHEMBL4468845 IC50 387.0 nM
O=C(NCCCNc1ccnc(Nc2cccc(NC(=O)N3CCCC3)c2)n1)C1CCC1 CHEMBL5075360 IC50 390.0 nM
COc1ccc(-c2cnc3[nH]cc(NC(=O)C4CCCC4)c3c2)cc1OC CHEMBL4475520 IC50 398.0 nM
CCc1nc(CCC(C)C)nc2ccc(-c3ccncc3)cc12 CHEMBL5187603 IC50 400.0 nM
Cn1nccc1Nc1nccc(-c2ccn([C@H](CO)c3ccc(Cl)c(F)c3)c(=O)c2)n1 CHEMBL3544964 Kd apparent 401.0 nM
COc1cc(Nc2ncc(F)c(Nc3ccc4c(n3)NC(=O)C(C)(C)O4)n2)cc(OC)c1OC CHEMBL475251 Kd 410.0 nM
COc1cc(NC(=O)[C@H](N)[C@H](C)O)ccc1-c1cnco1 CHEMBL4858951 IC50 410.0 nM
COc1ccc(-c2cnc3[nH]cc(C#Cc4ccc(C)cc4)c3c2)cc1OC CHEMBL4449852 IC50 420.0 nM
CC(C)CC(N)c1ncc2cc(-c3cnco3)ccc2n1 CHEMBL5172186 IC50 420.0 nM
CCc1nc(C(N)CC(C)C)nc2cc(OC)c(-c3ccncc3)cc12 CHEMBL5191369 IC50 420.0 nM
Cc1cc(-c2ccnc(Nc3cnn(C)c3)n2)ccc1CNC(=O)N1CC(OC(C)C)C1 CHEMBL4744041 Kd 430.0 nM
COc1cc(NC(=O)Cc2ccccc2)ccc1-c1cnco1 CHEMBL419143 IC50 430.0 nM
CNc1cc(-c2ccc(NC(=O)[C@H](N)CC(C)C)cc2OC)ccn1 CHEMBL4866426 IC50 450.0 nM
COc1ccc(-c2cnc3[nH]nc(NC(=O)c4cccnc4)c3c2)cc1OC CHEMBL4529052 IC50 462.0 nM
COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 CHEMBL509032 Kd 470.0 nM
COc1cc(NC(=O)[C@H](N)CC2CCCCC2)ccc1-c1cnco1 CHEMBL4847255 IC50 480.0 nM
COC(=O)Nc1cc(-c2cnc(OC[C@@](C)(N)CC(C)C)cc2C)ccn1 CHEMBL5180776 IC50 490.0 nM
CN(C)CC(=O)N1CCC(c2ccc(NC(=O)c3nc(C#N)c[nH]3)c(C3=CCCCC3)c2)CC1 CHEMBL1908395 Kd 520.0 nM
COc1cc(NC(=O)[C@H]2CCCCN2)ccc1-c1cnco1 CHEMBL4860264 IC50 550.0 nM
CC(=O)Nc1n[nH]c2cc(-c3cccc(NS(=O)(=O)C4CC4)c3)ccc12 CHEMBL4533288 IC50 560.0 nM
COc1ccc(-c2cnc3[nH]cc(NC(=O)Cc4ccccc4)c3c2)cc1OC CHEMBL4553067 IC50 612.0 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)N[C@H]4O CHEMBL574737 Kd apparent 623.0 nM
COc1cc(NC(=O)[C@H](N)Cc2ccccc2)ccc1-c1cnco1 CHEMBL4878393 IC50 630.0 nM
Nc1cccc(-c2ccc3c(NC(=O)C4CC4)n[nH]c3c2)c1 CHEMBL4449317 IC50 800.0 nM
Nc1nc(N)c2nc(-c3cccc(O)c3)c(-c3cccc(O)c3)nc2n1 CHEMBL230011 Kd 870.0 nM
CC(C)C[C@](C)(N)COc1ccc(-c2ccnc(C(C)C)n2)cc1F CHEMBL4066208 IC50 886.0 nM
CN(C)C[C@@H]1CCn2cc(c3ccccc32)C2=C(C(=O)NC2=O)c2cn(c3ccccc23)CCO1 CHEMBL91829 Kd 900.0 nM
NC(=O)c1ccc(-c2ccc3c(NC(=O)C4CC4)n[nH]c3c2)cc1 CHEMBL4456439 IC50 910.0 nM
COc1cc(NC(=O)[C@H](N)CC(C)C)ccc1-n1cncn1 CHEMBL4852601 IC50 920.0 nM
CO[C@@H]1[C@H](N(C)C(=O)c2ccccc2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)N[C@H]4O CHEMBL1240703 Kd 960.0 nM
CN1C(=O)[C@@H](N2CCc3cn(CC4CCS(=O)(=O)CC4)nc3C2=O)COc2ccccc21 CHEMBL4097778 pIC50 1000.0 nM