COc1ccccc1-c1ccc2nc(NC(=O)NCCN3CCN(C)CC3)sc2c1 CHEMBL2347725 IC50 0.015 nM
Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1 CHEMBL5416410 Kd 0.016 nM
Cc1c(F)cncc1-c1ccc2cc(NC(=O)[C@@H]3C[C@@H]3F)ncc2c1 CHEMBL3689722 Ki 0.0186 nM
Cn1c(=O)c(-c2c(Cl)cccc2Cl)cc2cnc(Nc3cccc(N)c3)nc21 CHEMBL577269 Ki 0.02 nM
Cn1c(=O)c(-c2c(Cl)cccc2Cl)cc2cnc(Nc3cccc(NC(=O)CN)c3)nc21 CHEMBL1221411 Ki 0.02 nM
Cc1ccc(O)cc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3685056 Ki 0.02 nM
Cc1ccncc1-c1ccc2cc(NC(=O)C3CC3F)ncc2c1 CHEMBL3685101 Ki 0.02 nM
Cc1c(F)cncc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3639840 Ki 0.02 nM
Cc1cc(CO)ncc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3685180 Ki 0.02 nM
Cc1c(-c2ccc3cc(NC(=O)C4CC4)ncc3c2)cnc(CO)c1F CHEMBL3689554 Ki 0.02 nM
Cc1cc([C@H](O)C(F)(F)F)ncc1-c1ccc2cc(NC(=O)C3C[C@@H]3F)ncc2c1 CHEMBL3689631 Ki 0.02 nM
Cc1ccc2[nH]ncc2c1-c1cc2cnc(NC(=O)[C@@H]3C[C@@H]3F)cc2cn1 CHEMBL3689678 Ki 0.02 nM
COc1ccccc1-c1ccc2nc(NC(=O)NCCN3CCOCC3)sc2c1 CHEMBL2347722 IC50 0.021 nM
COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl CHEMBL288441 Kd 0.029 nM
Cc1ccncc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3685020 Ki 0.03 nM
Cc1c(O)cccc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3685089 Ki 0.03 nM
Cc1cc(F)c(O)cc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3685095 Ki 0.03 nM
Cc1ccc(CO)cc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3685096 Ki 0.03 nM
Cc1ccc2[nH]ncc2c1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3689574 Ki 0.03 nM
Cc1cc([C@H](O)C(F)(F)F)ncc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3689596 Ki 0.03 nM
Cc1cc([C@@H](O)C(F)(F)F)ncc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3689597 Ki 0.03 nM
Cc1ccncc1-c1ccc2cc(NC(=O)C3C[C@H]3F)ncc2c1 CHEMBL3689608 Ki 0.03 nM
Cc1ccncc1-c1ccc2cc(NC(=O)C3C[C@@H]3F)ncc2c1 CHEMBL3689609 Ki 0.03 nM
CCNC(=O)Nc1nc2ccc(-c3ccccc3OCC)cc2s1 CHEMBL2347711 IC50 0.03 nM
O=C(Nc1cc2ccc(-c3cc(O)ccc3Cl)cc2cn1)C1CC1 CHEMBL3685023 Ki 0.04 nM
O=C(Nc1cc2ccc(-c3cccc4[nH]ncc34)cc2cn1)C1CC1 CHEMBL3685134 Ki 0.04 nM
Cc1c(O)cncc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3685179 Ki 0.04 nM
Cc1ncc2[nH]ncc2c1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3689575 Ki 0.04 nM
Cc1cc([C@@H](C)O)ncc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3689567 Ki 0.05 nM
Cc1cc([C@H](C)O)ncc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3689568 Ki 0.05 nM
Cc1ccncc1-c1ccc2cc(NC(=O)[C@@H]3C[C@@H]3F)ncc2c1 CHEMBL3689578 Ki 0.05 nM
N#Cc1cc(F)ccc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3685068 Ki 0.06 nM
Cc1ccncc1-c1ccc2cc(NC(=O)[C@H]3C[C@H]3F)ncc2c1 CHEMBL3689577 Ki 0.06 nM
CCNC(=O)Nc1nc2ccc(-c3ccccc3OC)cc2s1 CHEMBL2347710 IC50 0.06 nM
Cc1cc(-c2cc(O)ccc2Cl)cc2nnc(Nc3ccc(CCCN4CCCC4)cc3)nc12 CHEMBL250213 Ki 0.062 nM
Cc1cc(-c2cc(Cl)ccc2O)cc2nnc(Nc3ccc(OCCCN4CCCC4)cc3)nc12 CHEMBL5282076 Ki 0.062 nM
COc1ccccc1-c1ccc2nc(NC(=O)NCCO)sc2c1 CHEMBL2347723 IC50 0.064 nM
N#Cc1cc(F)c(F)cc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3685055 Ki 0.07 nM
O=C(Nc1cc2ccc(-c3cnccc3Cl)cc2cn1)C1CC1 CHEMBL3685147 Ki 0.07 nM
Cc1ccnc(CO)c1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3685181 Ki 0.07 nM
Cc1cccc(F)c1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3689696 Ki 0.0709 nM
O=C(Nc1cc2ccc(-c3cccc4[nH]nnc34)cc2cn1)C1CC1 CHEMBL3689719 Ki 0.0723 nM
C[C@@H]1CCC(=O)N1c1ccc2cc(NC(=O)C3C[C@@H]3F)ncc2c1 CHEMBL3689736 Ki 0.0799 nM
C[C@H]1CCC(=O)N1c1ccc2cc(NC(=O)C3C[C@@H]3F)ncc2c1 CHEMBL3689737 Ki 0.0799 nM
Cc1ccc(F)cc1-c1cc2cnc(NC(=O)C3CC3)cc2c(C)n1 CHEMBL3689649 Ki 0.08 nM
Cc1c(-c2ccc3cc(NC(=O)C4C[C@@H]4F)ncc3c2)cnc([C@@H](O)C(F)(F)F)c1Cl CHEMBL3689713 Ki 0.0841 nM
Cc1c(-c2ccc3cc(NC(=O)C4C[C@@H]4F)ncc3c2)cnc([C@H](O)C(F)(F)F)c1Cl CHEMBL3689714 Ki 0.0841 nM
Cc1ccc[n+]([O-])c1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3689723 Ki 0.0896 nM
Cc1ccc(F)cc1-c1ccc2cc(NC(=O)C3C[C@@H]3F)ncc2c1 CHEMBL3685048 Ki 0.09 nM
Cc1ccc(F)cc1-c1ccc2cc(NC(=O)C3C[C@H]3F)ncc2c1 CHEMBL3685049 Ki 0.09 nM
O=C(Nc1cc2ccc(-c3ccc(F)c(O)c3)cc2cn1)C1CC1 CHEMBL3685097 Ki 0.09 nM
Cc1c(N)cncc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3685178 Ki 0.09 nM
Cc1ccc(NC(=O)N2CCCC2)cc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3689548 Ki 0.09 nM
Cc1ccc(F)cc1-c1ccc2cc(NC(=O)C3CC3F)ncc2c1 CHEMBL3685009 Ki 0.1 nM
Cc1cccnc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3685035 Ki 0.1 nM
CNC(=O)Nc1cc2ccc(-c3cc(F)ccc3C)cc2cn1 CHEMBL3685072 Ki 0.1 nM
Cc1c[nH]nc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3685102 Ki 0.1 nM
Cc1cc(Cl)ncc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3685146 Ki 0.1 nM
Cc1ccncc1-c1ccc2cc(Nc3cc(CO)ccn3)ncc2c1 CHEMBL3685155 Ki 0.1 nM
O=C(Nc1cc2ccc(-c3cccnc3CO)cc2cn1)C1CC1 CHEMBL3685172 Ki 0.1 nM
Cc1ccc(NC(=O)c2ccc(CN(C)C)cc2)cc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3685177 Ki 0.1 nM
Cc1cc(C(C)(C)O)ncc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3689544 Ki 0.1 nM
CC[C@@H](O)c1cc(C)c(-c2ccc3cc(NC(=O)C4CC4)ncc3c2)cn1 CHEMBL3689563 Ki 0.1 nM
CC[C@H](O)c1cc(C)c(-c2ccc3cc(NC(=O)C4CC4)ncc3c2)cn1 CHEMBL3689564 Ki 0.1 nM
Cc1ncc(O)cc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3689606 Ki 0.1 nM
Cc1ccncc1-c1ccc2cc(NC(=O)C3CC3(F)F)ncc2c1 CHEMBL3689607 Ki 0.1 nM
Cc1cc([C@@H](O)C(F)(F)F)ncc1-c1ccc2cc(NC(=O)C3C[C@@H]3F)ncc2c1 CHEMBL3689632 Ki 0.1 nM
CNC(=O)Nc1cc2ccc(-c3cnccc3C)cc2cn1 CHEMBL3689633 Ki 0.1 nM
Cc1nc(-c2ccccc2Cl)cc2cnc(NC(=O)C3CC3)cc12 CHEMBL3689636 Ki 0.1 nM
Cc1ccc(F)cc1-c1cc2cnc(NC(=O)C3CC3)cc2cn1 CHEMBL3689646 Ki 0.1 nM
Cc1ccc(F)cc1-c1cc2cnc(NC(=O)C3CC3)cc2c(-c2cnn(C)c2)n1 CHEMBL3689666 Ki 0.1 nM
Cc1ccc(F)cc1-c1cc2cnc(NC(=O)C3CC3)cc2c(-c2cn[nH]c2)n1 CHEMBL3689667 Ki 0.1 nM
Cc1ccc(CO)cc1-c1cc2cnc(NC(=O)C3CC3)cc2cn1 CHEMBL3689670 Ki 0.1 nM
Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCOCCOCCN)CC2)n1 CHEMBL4474070 Ki 0.103 nM
CCNC(=O)Nc1nc2ccc(-c3ccc(N)cc3OC)cc2s1 CHEMBL2347719 IC50 0.11 nM
Cc1ccc(F)cc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3689700 Ki 0.116 nM
CCOc1ccccc1-c1ccc2nc(NC(=O)NCCN3CCNCC3)sc2c1 CHEMBL2347729 IC50 0.12 nM
CCOc1ccccc1-c1ccc2nc(NC(=O)NCCCO)sc2c1 CHEMBL2347728 IC50 0.13 nM
Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2[nH]ncc2c1 CHEMBL2316582 IC50 0.15 nM
Cc1cccc(Cl)c1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3689697 Ki 0.158 nM
O=C(Nc1cc2ccc(-c3cc(F)cc4[nH]ncc34)cc2cn1)C1CC1 CHEMBL3689720 Ki 0.158 nM
COc1ccccc1-c1ccc2nc(NC(=O)NCCCO)sc2c1 CHEMBL2347724 IC50 0.16 nM
O=C(Nc1cc2ccc(-c3c(F)ccc(F)c3Cl)cc2cn1)C1CC1 CHEMBL3689695 Ki 0.164 nM
Cc1cc[n+]([O-])cc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3689743 Ki 0.167 nM
Cc1c(F)cncc1-c1cc2cnc(NC(=O)[C@@H]3C[C@@H]3F)cc2cn1 CHEMBL3689718 Ki 0.168 nM
CN1CCN(Cc2ccc(NC(=O)c3cccc(C#Cc4cnc5[nH]ncc5c4)c3)cc2C(F)(F)F)CC1 CHEMBL2316583 IC50 0.17 nM
N#Cc1ccccc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3689706 Ki 0.173 nM
O=C(Nc1cc2ccc(-c3c(F)cccc3F)cc2cn1)C1CC1 CHEMBL3689699 Ki 0.175 nM
CCOc1ccccc1-c1ccc2nc(NC(=O)NCCO)sc2c1 CHEMBL2347727 IC50 0.18 nM
Cc1ccnc(CO)c1-c1ccc2cc(NC(=O)[C@@H]3C[C@@H]3F)ncc2c1 CHEMBL3689746 Ki 0.193 nM
CSc1cccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)c1 CHEMBL386051 Ki 0.2 nM
CNC(=O)c1ncc(C#Cc2cc(C(=O)Nc3ccc(CN4CCN(CCO)CC4)c(C(F)(F)F)c3)ccc2C)n1C CHEMBL1784637 IC50 0.2 nM
CN1CCN(Cc2ccc(NC(=O)Nc3cc(C#Cc4cnc5cccnn45)n(C)n3)cc2C(F)(F)F)CC1 CHEMBL2324926 IC50 0.2 nM
Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cncc2nccn12 CHEMBL2324924 IC50 0.2 nM
Cc1ccc(C#N)cc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3685045 Ki 0.2 nM
N#Cc1ccc(F)cc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3685066 Ki 0.2 nM
N#Cc1ccc(O)cc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3685088 Ki 0.2 nM
CCNC(=O)Nc1cc2ccc(-c3cc(F)ccc3C)cc2cn1 CHEMBL3685099 Ki 0.2 nM
COCCNC(=O)Nc1cc2ccc(-c3cc(F)ccc3C)cc2cn1 CHEMBL3685110 Ki 0.2 nM
Cc1ccc(F)cc1-c1ccc2cc(NC(=O)NC3COC3)ncc2c1 CHEMBL3685124 Ki 0.2 nM
O=C(Nc1cc2ccc(-c3cc(CO)ccc3Cl)cc2cn1)C1CC1 CHEMBL3685162 Ki 0.2 nM
Cc1ccc(F)cc1-c1ccc2cc(NC(=O)C3C[C@@H]3C)ncc2c1 CHEMBL3685169 Ki 0.2 nM
Cc1ccc(NC(=O)C2CCOCC2)cc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3685174 Ki 0.2 nM
Cc1ccc(F)cc1-c1ccc2cc(NC(=O)C3C[C@H]3C)ncc2c1 CHEMBL3685170 Ki 0.2 nM
Cc1c(CO)cncc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3685184 Ki 0.2 nM
Cc1ccncc1-c1ccc2cc(Nc3cccc(CO)n3)ncc2c1 CHEMBL3685187 Ki 0.2 nM
Cc1ccc(NC(=O)C2CN(C)CCO2)cc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3689547 Ki 0.2 nM
Cc1ccc(NC(=O)C2COCCO2)cc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3689565 Ki 0.2 nM
Cc1ccc(F)cc1-c1ccc2cc(NC(=O)C3CC3c3ccc(CN(C)C)cc3)ncc2c1 CHEMBL3689584 Ki 0.2 nM
Cc1ncc(NC(=O)c2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3689592 Ki 0.2 nM
Cc1ccc(NC(=O)N2CCC[C@@H]2CO)cc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3689602 Ki 0.2 nM
Cc1ccc(NC(=O)N2CCC[C@H]2CO)cc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3689603 Ki 0.2 nM
Cc1ccc(NC(=O)C2CCC2)c(F)c1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3689628 Ki 0.2 nM
Cc1ccc(F)cc1-c1cc2cnc(NC(=O)C3CC3)cc2c(CO)n1 CHEMBL3689653 Ki 0.2 nM
Cc1ccc(F)cc1-c1cc2cnc(NC(=O)C3CC3)cc2c(-c2cccnc2)n1 CHEMBL3689655 Ki 0.2 nM
Cc1ccc(F)cc1-c1cc2cnc(NC(=O)C3CC3)cc2c(CF)n1 CHEMBL3689658 Ki 0.2 nM
Cc1ccc(F)cc1-c1cc2cnc(NC(=O)C3CC3)cc2c(-c2ccncc2)n1 CHEMBL3689664 Ki 0.2 nM
Cc1ccc(F)cc1-c1cc2cnc(NC(=O)C3CC3)cc2c(-c2cc[nH]n2)n1 CHEMBL3689665 Ki 0.2 nM
Cc1ccc(F)cc1-c1cc2cnc(NC(=O)C3CC3)cc2c(C(C)(C)O)n1 CHEMBL3689668 Ki 0.2 nM
O=C(Nc1cc2ccc(OC3CCC[C@H]3O)cc2cn1)C1CC1 CHEMBL3689588 Ki 0.2 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(N2CC[C@@H](O)C2)c(-c2ccccn2)c1 CHEMBL4107478 IC50 0.2 nM
N[C@]1(C(F)(F)F)CCN(c2ncc(C(=O)Nc3ccc(OC(F)(F)F)cc3)cc2-c2cncnc2)C1 CHEMBL4109082 IC50 0.2 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(N2CC[C@H](CO)C2)c(-c2cncnc2)c1 CHEMBL3939040 IC50 0.2 nM
O=C(Nc1ccc(OC(F)(F)Cl)cc1)c1cnc(N2CC[C@H](CO)C2)c(-c2cncc(F)c2)c1 CHEMBL3908797 IC50 0.2 nM
CN(CCO)c1ncc(C(=O)Nc2ccc(OC(F)(F)Cl)cc2)cc1-c1cncc(C#N)c1 CHEMBL3937525 IC50 0.2 nM
O=C(Nc1ccc(SC(F)(F)F)cc1)c1cnc(N2CC[C@H](O)C2)c(-c2cncnc2)c1 CHEMBL3911446 IC50 0.2 nM
O=C(Nc1ccc(SC(F)(F)F)cc1)c1cnc(N2CC[C@@H](O)C2)c(-c2cncnc2)c1 CHEMBL4106732 IC50 0.2 nM
O=C(Nc1ccc(SC(F)(F)F)cc1)c1cnc(N2CC[C@@H](O)C2)c(-c2cncc(F)c2)c1 CHEMBL4113224 IC50 0.2 nM
N#Cc1cncc(-c2cc(C(=O)Nc3ccc(SC(F)(F)F)cc3)cnc2N2CC[C@@H](O)C2)c1 CHEMBL4107050 IC50 0.2 nM
Cc1ccncc1-c1cc(C(=O)Nc2ccc(OC(F)(F)Cl)cc2)cnc1N1CC[C@@H](O)C1 CHEMBL4112072 IC50 0.2 nM
CC1(O)CN(c2ncc(C(=O)Nc3ccc(OC(F)(F)F)cc3)cc2-c2ncc[nH]2)C1 CHEMBL3967070 IC50 0.2 nM
N[C@@H]1[C@H]2CN(c3ncc(C(=O)Nc4ccc(OC(F)(F)Cl)cc4)cc3-c3ccn[nH]3)C[C@@H]12 CHEMBL3910722 IC50 0.2 nM
NC1CN(c2ncc(C(=O)Nc3ccc(OC(F)(F)Cl)cc3)cc2-c2ccn[nH]2)C1 CHEMBL3981232 IC50 0.2 nM
O=C(Nc1ccc(OC(F)(F)Cl)cc1)c1cnc(N2CC(O)C2)c(-c2[nH]ncc2F)c1 CHEMBL3903802 IC50 0.2 nM
Cc1cc(-c2cc(C(=O)Nc3ccc(OC(F)(F)Cl)cc3)cnc2N2CC(O)C2)[nH]n1 CHEMBL3965179 IC50 0.2 nM
CN1CCN(Cc2ccc(NC(=O)CCSc3ccc4c(/C=C/c5ccccn5)n[nH]c4c3)cc2C(F)(F)F)CC1 CHEMBL4439424 IC50 0.2 nM
Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1ncc2cccnn12 CHEMBL4519289 IC50 0.2 nM
CNC(=O)c1ccccc1Sc1ccc2c(/C=C/c3ccccn3)n[nH]c2c1 CHEMBL1289926 IC50 0.2 nM
Cc1cccc(C)c1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3639885 Ki 0.204 nM
Cc1cc(C(C)(C)O)ncc1-c1cc2cnc(NC(=O)[C@@H]3C[C@@H]3F)cc2cn1 CHEMBL3689740 Ki 0.218 nM
CCOc1ccccc1-c1ccc2nc(NC(=O)NCCN3CCOCC3)sc2c1 CHEMBL2347726 IC50 0.23 nM
O=C(Nc1cc2ccc(-c3c(F)cc(F)cc3Cl)cc2cn1)C1CC1 CHEMBL3689694 Ki 0.236 nM
Cc1ccnc([C@@H](C)O)c1-c1ccc2cc(NC(=O)C3C[C@@H]3F)ncc2c1 CHEMBL3689729 Ki 0.246 nM
Cc1ccnc([C@H](C)O)c1-c1ccc2cc(NC(=O)C3C[C@@H]3F)ncc2c1 CHEMBL3689732 Ki 0.246 nM
COc1ccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(CCO)c5)cnc(N)c34)cc2)cc1 CHEMBL1977148 pKi 0.2512 nM
Cc1ccnc([C@@H](O)C(F)(F)F)c1-c1ccc2cc(NC(=O)C3C[C@@H]3F)ncc2c1 CHEMBL3689730 Ki 0.265 nM
Cc1ccnc([C@H](O)C(F)(F)F)c1-c1ccc2cc(NC(=O)C3C[C@@H]3F)ncc2c1 CHEMBL3689731 Ki 0.265 nM
Cc1c(-c2ccc3cc(NC(=O)[C@@H]4C[C@@H]4F)ncc3c2)cnc(C(C)(C)O)c1F CHEMBL3689721 Ki 0.268 nM
Cc1cc(-c2cc(O)ccc2Cl)cc2nnc(Nc3ccc(S(=O)(=O)N(C)CCN4CCCC4)cc3)nc12 CHEMBL250019 Ki 0.3 nM
CN1CCN(Cc2ccc(NC(=O)Nc3cc(C#Cc4cnc5cnccn45)n(C)n3)cc2C(F)(F)F)CC1 CHEMBL2324925 IC50 0.3 nM
Cc1cc(F)ccc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3685016 Ki 0.3 nM
CC(=O)Nc1cc2ccc(-c3cc(F)ccc3C)cc2cn1 CHEMBL3685041 Ki 0.3 nM
COCC(=O)Nc1cc2ccc(-c3cc(F)ccc3C)cc2cn1 CHEMBL3685044 Ki 0.3 nM
O=C(Nc1cc2ccc(-c3cccc4[nH]ccc34)cc2cn1)C1CC1 CHEMBL3685054 Ki 0.3 nM
Cc1ccnc(C)c1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3685080 Ki 0.3 nM
Cc1ccc(NC(=O)c2ccc(CN3CCN(C)CC3)cc2)cc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3685139 Ki 0.3 nM
Cc1ccc(NC(=O)c2ccc(C(C)N(C)C)cc2)cc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3685186 Ki 0.3 nM
Cc1ccc(NC(=O)C2CCC2)cc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3689540 Ki 0.3 nM
O=C(Nc1cc2ccc(-c3cnccc3C(F)(F)F)cc2cn1)C1CC1 CHEMBL3689553 Ki 0.3 nM
Cc1ccc(NC(=O)c2ccc(C3CCCN3C)cc2)cc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3689558 Ki 0.3 nM
Cc1ccc(NC(=O)C2(O)CCC2)cc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3689594 Ki 0.3 nM
Cc1ccc(NC(=O)N2CCC2)cc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3689600 Ki 0.3 nM
Cc1ccc(C(=O)NC2(C)CCC2)cc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3689610 Ki 0.3 nM
O=C(Nc1cc2cnc(-c3ccccc3Cl)cc2cn1)C1CC1 CHEMBL3689637 Ki 0.3 nM
CCc1nc(-c2ccccc2Cl)cc2cnc(NC(=O)C3CC3)cc12 CHEMBL3689642 Ki 0.3 nM
Cc1ccncc1-c1cc2cnc(NC(=O)C3CC3)cc2cn1 CHEMBL3689645 Ki 0.3 nM
Cc1ccc(F)cc1-c1cc2cnc(NC(=O)C3CC3)cc2c(C)[n+]1[O-] CHEMBL3689647 Ki 0.3 nM
Cc1ccc(F)cc1-c1cc2cnc(NC(=O)C3CC3)cc2c(-c2ccnn2C)n1 CHEMBL3689659 Ki 0.3 nM
Cc1ccc(F)cc1-c1cc2cnc(NC(=O)C3CC3)cc2c(S(C)(=O)=O)n1 CHEMBL3689660 Ki 0.3 nM
Cc1nc(C)c(-c2nc(-c3cc(F)ccc3C)cc3cnc(NC(=O)C4CC4)cc23)s1 CHEMBL3689662 Ki 0.3 nM
O=C(Nc1cc2ncc(-c3cc(F)ccc3Cl)cc2cn1)C1CC1 CHEMBL3689680 Ki 0.3 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(N2CC[C@H](CO)C2)c(-c2cnc(Cl)c(F)c2)c1 CHEMBL3922791 IC50 0.3 nM
NC[C@@H]1CCN(c2ncc(C(=O)Nc3ccc(OC(F)(F)F)cc3)cc2-c2cncnc2)C1 CHEMBL3901163 IC50 0.3 nM
O=C(Nc1ccc(OC(F)(F)Cl)cc1)c1cnc(N2CC[C@@H](O)C2)c(-c2cccnc2F)c1 CHEMBL4108934 IC50 0.3 nM
NC[C@@H]1CCN(c2ncc(C(=O)Nc3ccc(OC(F)(F)Cl)cc3)cc2-c2cncnc2)C1 CHEMBL3944135 IC50 0.3 nM
O=C(Nc1ccc(OC(F)(F)Cl)cc1)c1cnc(N2CC[C@@H](O)C2)c(-c2cnccc2F)c1 CHEMBL4111359 IC50 0.3 nM
COc1ncc(-c2cc(C(=O)Nc3ccc(OC(F)(F)Cl)cc3)cnc2N2CC[C@@H](O)C2)cc1C#N CHEMBL4111085 IC50 0.3 nM
Cc1ccc(C(=O)Nc2ccc(CN3CCN(CCO)CC3)c(C3CC3)c2)cc1C#Cc1cnc2cccnn12 CHEMBL4632471 IC50 0.3 nM
Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12 CHEMBL1171837 IC50 0.3 nM
Cc1cc(-c2cc(Cl)ccc2O)cc2nnc(Nc3ccc(S(=O)(=O)N(C)CCN4CCCC4)cc3)nc12 CHEMBL5277744 Ki 0.3 nM
CCNC(=O)Nc1nc2ccc(-c3ccccc3)cc2s1 CHEMBL2347716 IC50 0.31 nM
O=C(Nc1cc2ccc(-c3ccccc3Cl)cc2cn1)C1CC1 CHEMBL3689707 Ki 0.312 nM
O=C(Nc1cc2ccc(-c3cc(F)ccc3F)cc2cn1)C1CC1 CHEMBL3689698 Ki 0.349 nM
Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCOCCOCCNC(=O)CCCCCC3(C)C(/C=C/C=C/C=C4/N(CCCS(=O)(=O)O)c5ccc(S(=O)(=O)O)cc5C4(C)C)=[N+](CCCS(=O)(=O)[O-])c4ccc(S(=O)(=O)O)cc43)CC2)n1 CHEMBL4460292 Ki 0.35 nM
Cc1ccc(C(=O)Nc2ccc(CN3CCN(CCO)CC3)c(Cl)c2)cc1C#Cc1cnc2cccnn12 CHEMBL4642144 IC50 0.39 nM
COc1cc(Nc2c(C#N)cnc3cc(-c4coc(CN5CCN(C)CC5)c4)c(OC)cc23)c(Cl)cc1Cl CHEMBL219557 IC50 0.4 nM
CCN(CCN1CCCC1)S(=O)(=O)c1ccc(Nc2nnc3cc(-c4cc(O)ccc4Cl)cc(C)c3n2)cc1 CHEMBL250021 Ki 0.4 nM
COc1cc(Nc2c(C#N)cnc3cc(/C=C/CCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl CHEMBL1088240 IC50 0.4 nM
Cc1ccc(F)cc1-c1ccc2cc(NC(=O)C3CC3(F)F)ncc2c1 CHEMBL3685010 Ki 0.4 nM
CC(C)Oc1ccc(F)cc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3685019 Ki 0.4 nM
O=C(Nc1cc2ccc(-c3cnccc3CO)cc2cn1)C1CC1 CHEMBL3685191 Ki 0.4 nM
Cc1ccc(NC(=O)[C@@H]2CCCO2)cc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3685199 Ki 0.4 nM
CN1CCN(Cc2ccc(C(=O)Nc3ccc(Cl)c(-c4ccc5cc(NC(=O)C6CC6)ncc5c4)c3)cc2)CC1 CHEMBL3689539 Ki 0.4 nM
Cc1ccc(NC(=O)N2CCOCC2)cc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3689546 Ki 0.4 nM
Cc1ccc(NC(=O)c2ccc(CN3CCN(C)CC3)cc2)cc1-c1ccc2cc(N)ncc2c1 CHEMBL3689576 Ki 0.4 nM
Cc1ccncc1-c1ccc2cc(NC(=O)C3C4COCC43)ncc2c1 CHEMBL3689579 Ki 0.4 nM
Cc1ccc(NC(=O)N2CC[C@@H](O)C2)cc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3689604 Ki 0.4 nM
O=C(Nc1cc2cnc(-c3cc(F)ccc3Cl)cc2cn1)C1CC1 CHEMBL3689634 Ki 0.4 nM
Cc1ccc(F)cc1-c1cc2cnc(NC(=O)C3CC3)cc2c[n+]1[O-] CHEMBL3689648 Ki 0.4 nM
Cc1ccc(F)cc1-c1cc2cnc(NC(=O)C3CC3)cc2c(-c2ccccc2)n1 CHEMBL3689661 Ki 0.4 nM
Cc1ccc(F)cc1-c1cc2cnc(NC(=O)C3CC3)cc2c(C2CCOC2)n1 CHEMBL3689676 Ki 0.4 nM
Cc1ccncc1-c1cc2cnc(NC(=O)[C@@H]3C[C@@H]3F)cc2cn1 CHEMBL3689677 Ki 0.4 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)c1ccc(N2CCOC2=O)c(-c2cncnc2)c1 CHEMBL3986132 IC50 0.4 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(N2CC[C@@H](O)C2)c(-c2cnc(Cl)c(F)c2)c1 CHEMBL4113492 IC50 0.4 nM
C[C@@]1(O)CCN(c2ncc(C(=O)Nc3ccc(OC(F)(F)F)cc3)cc2-c2cncnc2)C1 CHEMBL4107083 IC50 0.4 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(N2C[C@H](O)[C@@H](O)C2)c(-c2cccnc2)c1 CHEMBL3891752 IC50 0.4 nM
Cc1ncc(-c2cc(C(=O)Nc3ccc(OC(F)(F)F)cc3)cnc2N2CC(CO)C2)cc1F CHEMBL3977018 IC50 0.4 nM
CC(=O)NC[C@H]1CCN(c2ncc(C(=O)Nc3ccc(OC(F)(F)Cl)cc3)cc2-c2cncnc2)C1 CHEMBL4113008 IC50 0.4 nM
CN(CCO)c1ncc(C(=O)Nc2ccc(OC(F)(F)Cl)cc2)cc1-c1cncc(F)c1 CHEMBL3909590 IC50 0.4 nM
CN(CCO)c1ncc(C(=O)Nc2ccc(SC(F)(F)F)cc2)cc1-c1cncc(F)c1 CHEMBL3974180 IC50 0.4 nM
O=C(Nc1ccc(OC(F)(F)F)c(F)c1)c1cnc(N2CC[C@@H](O)C2)c(-c2cncnc2)c1 CHEMBL4115148 IC50 0.4 nM
O=C(Nc1ccc(SC(F)(F)Cl)cc1)c1cnc(N2CC[C@@H](O)C2)c(-c2cncnc2)c1 CHEMBL4108373 IC50 0.4 nM
O=C(Nc1ccc(OC(F)(F)Cl)cc1)c1cnc(N2CCNC3(CC3)C2)c(-c2cncnc2)c1 CHEMBL3942117 IC50 0.4 nM
N#Cc1cncc(-c2cc(C(=O)Nc3ccc(OC(F)(F)Cl)cc3)cnc2N2C[C@@H](O)[C@@H](O)C2)c1 CHEMBL3901435 IC50 0.4 nM
N#Cc1ccncc1-c1cc(C(=O)Nc2ccc(OC(F)(F)Cl)cc2)cnc1N1CC[C@@H](O)C1 CHEMBL4107740 IC50 0.4 nM
NC[C@H]1CN(c2ncc(C(=O)Nc3ccc(OC(F)(F)Cl)cc3)cc2-c2ccn[nH]2)C[C@H]1O CHEMBL3899379 IC50 0.4 nM
N#Cc1ccc(-c2cc(C(=O)Nc3ccc(OC(F)(F)Cl)cc3)cnc2N2C[C@H](O)[C@@H](O)C2)[nH]1 CHEMBL3939643 IC50 0.4 nM
NC12CC1CN(c1ncc(C(=O)Nc3ccc(OC(F)(F)Cl)cc3)cc1-c1ccn[nH]1)C2 CHEMBL3916724 IC50 0.4 nM
O=C(Nc1ccc(OC(F)(F)Cl)cc1)c1cnc(N2CC[C@@H](O)C2)c(-c2ncc[nH]2)c1 CHEMBL4114966 IC50 0.4 nM
C[C@@]1(O)CCN(c2ncc(C(=O)Nc3ccc(OC(F)(F)Cl)cc3)cc2-c2ccn[nH]2)C1 CHEMBL4113707 IC50 0.4 nM
NCC1(O)CCN(c2ncc(C(=O)Nc3ccc(OC(F)(F)Cl)cc3)cc2-c2ccn[nH]2)C1 CHEMBL3929270 IC50 0.4 nM
Cc1ccc(C(=O)Nc2cc(CN3CCN(C)CC3)cc(C(F)(F)F)c2)cc1C#Cc1cnc2cnccn12 CHEMBL4161036 IC50 0.4 nM
CCN(CCN1CCCC1)S(=O)(=O)c1ccc(Nc2nnc3cc(-c4cc(Cl)ccc4O)cc(C)c3n2)cc1 CHEMBL5270516 Ki 0.4 nM
Cc1ccc(C(=O)NC2CCC2)cc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3689749 Ki 0.417 nM
Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCOCCOCCNC(=O)OC(C)(C)C)CC2)n1 CHEMBL4469856 Ki 0.418 nM
COc1cc(Nc2c(C#N)cnc3cc(-c4coc(CN5CCN(c6ccccc6)CC5)c4)c(OC)cc23)c(Cl)cc1Cl CHEMBL278495 IC50 0.43 nM
COc1cc(Nc2c(C#N)cnc3cc(-c4coc(CN(C)C)c4)c(OC)cc23)c(Cl)cc1Cl CHEMBL219964 IC50 0.43 nM
COc1cc(Nc2c(C#N)cnc3cc(-c4coc(CN5CCN(C)CC5)c4)ccc23)c(Cl)cc1Cl CHEMBL219260 IC50 0.43 nM
Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2[nH]nc(C3CC3)c2c1 CHEMBL2316870 IC50 0.43 nM
Cc1ccncc1-c1cc2cnc(NC(=O)C3CC3F)cc2cn1 CHEMBL3689715 Ki 0.434 nM
CCO[C@@H]1CC1C(=O)Nc1cc2ccc(-c3cnccc3C)cc2cn1 CHEMBL3689727 Ki 0.45 nM
CCO[C@H]1CC1C(=O)Nc1cc2ccc(-c3cnccc3C)cc2cn1 CHEMBL3689728 Ki 0.45 nM
Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCOCCOCCNC(=O)CS(=O)(=O)O)CC2)n1 CHEMBL4439020 Ki 0.49 nM
Cc1cc(-c2cc(O)ccc2Cl)cc2nnc(Nc3ccc(C(=O)N4CCN(C)CC4)cc3)nc12 CHEMBL399246 Ki 0.5 nM
Cc1cccc(C)c1/C=C/n1cnc2c(Nc3ccc(P(C)(C)=O)cc3)nc(Oc3cccnc3)nc21 CHEMBL518166 IC50 0.5 nM
Cc1cc(F)c(F)cc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3685024 Ki 0.5 nM
CCC(=O)Nc1cc2ccc(-c3cc(F)ccc3C)cc2cn1 CHEMBL3685057 Ki 0.5 nM
O=C(Nc1cc2ccc(-c3cc[nH]n3)cc2cn1)C1CC1 CHEMBL3685062 Ki 0.5 nM
Cc1ncncc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3685074 Ki 0.5 nM
O=C(Nc1cc2ccc(-c3cncc(F)c3)cc2cn1)C1CC1 CHEMBL3685085 Ki 0.5 nM
CN1CCN(Cc2ccc(C(=O)Nc3ccc(F)c(-c4ccc5cc(NC(=O)C6CC6)ncc5c4)c3)cc2)CC1 CHEMBL3689538 Ki 0.5 nM
C[C@H](CO)Cc1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3689541 Ki 0.5 nM
C[C@@H](CO)Cc1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3689542 Ki 0.5 nM
Cc1ccc(NC(=O)N2CCOC(CO)C2)cc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3689549 Ki 0.5 nM
Cc1ccc(C(=O)NC2CCCC2)cc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3689612 Ki 0.5 nM
Nc1ncc(-c2cc(C(=O)Nc3ccc(OC(F)(F)Cl)cc3)cnc2N2CC[C@@H](O)C2)cc1F CHEMBL4112697 IC50 0.5 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(N2CC[C@@H](O)C2)c(-c2cc(F)cc(F)c2)c1 CHEMBL4115607 IC50 0.5 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(N2CCCC2)c(-c2ccc(CO)nc2)c1 CHEMBL3907285 IC50 0.5 nM
CCN(CCO)c1ncc(C(=O)Nc2ccc(OC(F)(F)Cl)cc2)cc1-c1cncc(F)c1 CHEMBL3915069 IC50 0.5 nM
O=C(Nc1ccc(SC(F)(F)F)cc1)c1cnc(N2CC[C@H](CO)C2)c(-c2cncc(F)c2)c1 CHEMBL3971948 IC50 0.5 nM
O=C(Nc1ccc(SC(F)(F)F)c(F)c1)c1cnc(N2CC[C@@H](O)C2)c(-c2cncc(F)c2)c1 CHEMBL4107476 IC50 0.5 nM
O=C(Nc1ccc(C(F)(F)C(F)(F)F)cc1)c1cnc(N2CC[C@@H](O)C2)c(-c2cncc(F)c2)c1 CHEMBL4107521 IC50 0.5 nM
O=C(Nc1ccc(OC(F)(F)Cl)cc1)c1ccc(N2CC[C@@H](O)C2)c(-c2cncnc2)c1 CHEMBL4107045 IC50 0.5 nM
NC12CC1CN(c1ncc(C(=O)Nc3ccc(OC(F)(F)Cl)cc3)cc1-c1cncnc1)C2 CHEMBL3931127 IC50 0.5 nM
N[C@@H]1[C@H]2CN(c3ncc(C(=O)Nc4ccc(OC(F)(F)Cl)cc4)cc3-c3cncnc3)C[C@@H]12 CHEMBL3900938 IC50 0.5 nM
O=C(Nc1ccc(C(F)(F)C(F)(F)Cl)cc1)c1cnc(N2CC[C@@H](O)C2)c(-c2cncnc2)c1 CHEMBL4108652 IC50 0.5 nM
N#Cc1ncc(F)cc1-c1cc(C(=O)Nc2ccc(OC(F)(F)Cl)cc2)cnc1N1CC[C@@H](O)C1 CHEMBL4108718 IC50 0.5 nM
O=C(Nc1ccc(OC(F)(F)Cl)cc1)c1cnc(N2CC[C@@H](O)C2)c(-c2cncnc2)c1 CHEMBL4110570 IC50 0.5 nM
O=C(Nc1ccc(OC(F)(F)Cl)cc1)c1cnc(N2CC[C@@H](O)C2)c(-c2cncc(F)c2)c1 CHEMBL4106838 IC50 0.5 nM
O=C(Nc1ccc(OC(F)(F)Cl)cc1)c1cnc(N2CC(CO)C2)c(-c2ccn[nH]2)c1 CHEMBL3911557 IC50 0.5 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(N2CC[C@@H](O)C2)c(-c2cncs2)c1 CHEMBL4110991 IC50 0.5 nM
N#Cc1ccc(-c2cc(C(=O)Nc3ccc(OC(F)(F)F)cc3)ccc2N2C[C@H](O)[C@@H](O)C2)[nH]1 CHEMBL3900366 IC50 0.5 nM
O=C(Nc1ccc(OC(F)(F)Cl)cc1)c1cnc(N2CC(O)C2)c(-c2ccn[nH]2)c1 CHEMBL3950047 IC50 0.5 nM
O=C(Nc1ccc(OC(F)(F)Cl)cc1)c1cnc(N2C[C@H](O)[C@@H](F)C2)c(-c2ccn[nH]2)c1 CHEMBL3936374 IC50 0.5 nM
O=C(Nc1ccc(OC(F)(F)Cl)cc1)c1cnc(N2C[C@H](O)[C@@H](O)C2)c(-c2cncnc2)c1 CHEMBL3898258 IC50 0.5 nM
O=C(Nc1ccc(OC(F)(F)Cl)cc1)c1cnc(N2CC[C@@H](O)C2)c(-c2cc[nH]n2)c1 CHEMBL4208229 IC50 0.5 nM
Cc1cccc(Cl)c1NC(=O)c1cnc(NC(=O)c2ccc(CN3CCN(C)CC3)cc2)s1 CHEMBL5190052 IC50 0.5 nM
Cc1cc(-c2cc(Cl)ccc2O)cc2nnc(Nc3ccc(C(=O)N4CCN(C)CC4)cc3)nc12 CHEMBL5282277 Ki 0.5 nM
CNC(=O)c1cnc(N)c2c(-c3ccc(NC(=O)Nc4cccc(Cl)c4)cc3)csc12 CHEMBL1982476 pKi 0.5012 nM
CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)cc1 CHEMBL49120 pKi 0.5012 nM
Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCOCCOCCNC(=O)C3C(C(=O)O)C(C(=O)O)C3C(=O)O)CC2)n1 CHEMBL4451230 Ki 0.507 nM
CCNC(=O)Nc1nc2ccc(-c3ccncc3OC)cc2s1 CHEMBL2347721 IC50 0.51 nM
Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2[nH]nc(C)c2c1 CHEMBL2316869 IC50 0.53 nM
CN[C@@H](C)C(=O)N[C@H](C(=O)N1CCC[C@H]1c1nc(C(=O)c2cccc(OCCCOCC(=O)N3CCN(c4cc(Nc5ncc(C(=O)Nc6c(C)cccc6Cl)s5)nc(C)n4)CC3)c2)cs1)C1CCCCC1 CHEMBL5182618 IC50 0.54 nM
O=C(Nc1cc2ccc(-c3ccccc3F)cc2cn1)C1CC1 CHEMBL3689708 Ki 0.545 nM
CN1CCN(Cc2ccc(NC(=O)c3ccc(Cl)c(C#Cc4cnc5[nH]ncc5c4)c3)cc2C(F)(F)F)CC1 CHEMBL2316586 IC50 0.57 nM
Cc1ccc(C(=O)NC2(CO)CCC2)cc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3689745 Ki 0.586 nM
CC(C)n1nc(C#Cc2cccc(NC(=O)c3cccc(C(F)(F)F)c3)c2)c2c(N)ncnc21 CHEMBL3736320 IC50 0.6 nM
COc1ccc(F)cc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3685018 Ki 0.6 nM
COc1ccc(C)c(-c2ccc3cc(NC(=O)C4CC4)ncc3c2)c1 CHEMBL3685075 Ki 0.6 nM
Cc1ccc(F)cc1-c1ccc2cc(Nc3cc(CO)ccn3)ncc2c1 CHEMBL3685119 Ki 0.6 nM
Cc1ccc(F)cc1-c1ccc2cc(NC(=O)NC3CCOCC3)ncc2c1 CHEMBL3685133 Ki 0.6 nM
O=C1Cc2c(cccc2-c2ccc3cc(NC(=O)C4CC4)ncc3c2)N1 CHEMBL3685150 Ki 0.6 nM
Cc1ccc(NC(=O)[C@H]2CCCO2)cc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3685198 Ki 0.6 nM
Cc1ccc(NC(=O)C2CCOC2)cc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3689543 Ki 0.6 nM
Cc1ccc(NC(=O)N2CC[C@H](O)C2)cc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3689605 Ki 0.6 nM
Cc1ccc(C(=O)Nc2cnn(C)c2)cc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3689616 Ki 0.6 nM
NCC1CN(c2ncc(C(=O)Nc3ccc(OC(F)(F)F)cc3)cc2-c2cncc(F)c2)CC1O CHEMBL3909587 IC50 0.6 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(N2CC[C@@H](O)C2)c(-c2cccnc2)c1 CHEMBL4111355 IC50 0.6 nM
Cc1ncc(-c2cc(C(=O)Nc3ccc(OC(F)(F)F)cc3)cnc2N2CC[C@@H](O)C2)cc1F CHEMBL4107812 IC50 0.6 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(N2CC[C@@H](O)C2)c(-c2cccc(F)c2)c1 CHEMBL4114005 IC50 0.6 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(N2CC[C@@H](CO)C2)c(-c2cncnc2)c1 CHEMBL4113536 IC50 0.6 nM
Cc1ccc(-c2cc(C(=O)Nc3ccc(OC(F)(F)F)cc3)cnc2N2CC[C@H](CO)C2)cn1 CHEMBL3902058 IC50 0.6 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(N2CC[C@H](CO)C2)c(-c2cncc(F)c2)c1 CHEMBL3907286 IC50 0.6 nM
NC[C@H]1CCN(c2ncc(C(=O)Nc3ccc(OC(F)(F)F)cc3)cc2-c2cncnc2)C1 CHEMBL4109872 IC50 0.6 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(N2CCC[C@H](O)C2)c(-c2cncnc2)c1 CHEMBL3910619 IC50 0.6 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(N2CC(CO)C2)c(-c2cccnc2)c1 CHEMBL3896096 IC50 0.6 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(N2CC(CO)C2)c(-c2cncc(F)c2)c1 CHEMBL3908712 IC50 0.6 nM
N#Cc1cncc(-c2cc(C(=O)Nc3ccc(OC(F)(F)Cl)cc3)cnc2N2CC[C@H](CO)C2)c1 CHEMBL3951931 IC50 0.6 nM
CCN(CCO)c1ncc(C(=O)Nc2ccc(OC(F)(F)Cl)cc2)cc1-c1cncnc1 CHEMBL3934436 IC50 0.6 nM
O=C(Nc1ccc(C(F)(F)C(F)(F)F)cc1)c1cnc(N2CC[C@@H](O)C2)c(-c2cncnc2)c1 CHEMBL4107401 IC50 0.6 nM
O=C(Nc1ccc(SC(F)(F)Cl)cc1)c1cnc(N2CC[C@@H](O)C2)c(-c2cncc(F)c2)c1 CHEMBL4106602 IC50 0.6 nM
O=C(Nc1ccc(OC(F)(F)Cl)cc1)c1ccc(N2C[C@H](O)[C@@H](O)C2)c(-c2cncnc2)c1 CHEMBL3904200 IC50 0.6 nM
O=C(Nc1ccc(OC(F)(F)Cl)cc1)c1cnc(N2Cc3cn[nH]c3C2)c(-c2cncnc2)c1 CHEMBL3986873 IC50 0.6 nM
O=C(Nc1ccc(OC(F)(F)Cl)cc1)c1cnc(N2CC[C@@H](CO)[C@@H](O)C2)c(-c2cncnc2)c1 CHEMBL3943799 IC50 0.6 nM
O=C(Nc1ccc(OC(F)(F)Cl)cc1)c1cnc(N2C[C@@H](O)[C@@H](O)C2)c(-c2cncc(F)c2)c1 CHEMBL3915875 IC50 0.6 nM
NCC1CN(c2ncc(C(=O)Nc3ccc(OC(F)(F)Cl)cc3)cc2-c2cncc(F)c2)CC1O CHEMBL3938427 IC50 0.6 nM
Cc1ncccc1-c1cc(C(=O)Nc2ccc(OC(F)(F)Cl)cc2)cnc1N1CC[C@@H](O)C1 CHEMBL4113303 IC50 0.6 nM
N[C@H]1CN(c2ccc(C(=O)Nc3ccc(OC(F)(F)Cl)cc3)cc2-c2cncc(F)c2)C[C@@H]1O CHEMBL3906709 IC50 0.6 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)c1ccc(N2C[C@H](CO)[C@@H](O)C2)c(-c2cncs2)c1 CHEMBL4106560 IC50 0.6 nM
COc1cc2ncc(-c3cccc(NC4CCNC4)n3)n2cc1-c1cnn(C)c1 CHEMBL5176837 IC50 0.6 nM
CCOc1ccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(C)c5)cnc(N)c34)cc2)cc1 CHEMBL1974254 pKi 0.631 nM
COCCN1CCN(Cc2ccc(NC(=O)c3ccc(C)c(C#Cc4cnc5cccnn45)c3)cc2C2CC2)CC1 CHEMBL4637502 IC50 0.65 nM
Cc1ccc(Cl)cc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3689701 Ki 0.671 nM
CCN1CCN(Cc2ccc(NC(=O)Nc3ccc(Oc4cc(NC)ncn4)cc3)cc2C(F)(F)F)CC1 CHEMBL574738 Kd 0.68 nM
CN1CCN(Cc2ccc(NC(=O)Nc3cc(C#Cc4cncc5nccn45)n(C)n3)cc2C(F)(F)F)CC1 CHEMBL2324923 IC50 0.7 nM
Cc1cc(C)c(-c2ccc3cc(NC(=O)C4CC4)ncc3c2)cn1 CHEMBL3685060 Ki 0.7 nM
Cc1ncc(F)cc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3685063 Ki 0.7 nM
O=C(Nc1cc2ccc(-c3ccc[nH]3)cc2cn1)C1CC1 CHEMBL3685087 Ki 0.7 nM
Cc1ccc(F)cc1-c1ccc2c(F)c(NC(=O)C3CC3)ncc2c1 CHEMBL3685115 Ki 0.7 nM
CC(C)Nc1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3685138 Ki 0.7 nM
Cc1ccc(NC(=O)c2ccc(CN3CCN(C)CC3)c(Cl)c2)cc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3685140 Ki 0.7 nM
Cc1ccc(NC(=O)c2ccc(C3CCN(C)C3)cc2)cc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3689559 Ki 0.7 nM
Cc1ccncc1-c1ccc2c(C#N)c(NC(=O)C3CC3)ncc2c1 CHEMBL3689620 Ki 0.7 nM
Cc1ccc(F)cc1-c1cc2cnc(NC(=O)C3CC3)cc2c(OC2CCNCC2)n1 CHEMBL3689671 Ki 0.7 nM
Cc1ncc(-c2cc(C(=O)Nc3ccc(OC(F)(F)F)cc3)cnc2N2CC[C@H](CO)C2)cc1F CHEMBL3931751 IC50 0.7 nM
N#Cc1cncc(-c2cc(C(=O)Nc3ccc(OC(F)(F)F)cc3)cnc2N2CC[C@H](CO)C2)c1 CHEMBL3976713 IC50 0.7 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(N2C[C@H](CO)[C@@H](O)C2)c(-c2cncc(F)c2)c1 CHEMBL4115522 IC50 0.7 nM
CCN(CCO)c1ncc(C(=O)Nc2ccc(SC(F)(F)F)cc2)cc1-c1cncc(F)c1 CHEMBL3921200 IC50 0.7 nM
O=C(Nc1ccc(OC(F)(F)F)c(F)c1)c1cnc(N2CC[C@H](CO)C2)c(-c2cncc(F)c2)c1 CHEMBL3924434 IC50 0.7 nM
O=C(Nc1ccc(OC(F)(F)Cl)cc1)c1cnc(N2C[C@@H](O)[C@@H](O)C2)c(-c2cncnc2)c1 CHEMBL3942231 IC50 0.7 nM
CN(C)[C@H]1CN(c2ncc(C(=O)Nc3ccc(OC(F)(F)Cl)cc3)cc2-c2cncnc2)C[C@@H]1O CHEMBL3941486 IC50 0.7 nM
Cc1ncc(-c2cc(C(=O)Nc3ccc(OC(F)(F)Cl)cc3)cnc2N2C[C@H](O)[C@@H](O)C2)cn1 CHEMBL3928323 IC50 0.7 nM
N[C@]1(C(F)(F)F)CCN(c2ncc(C(=O)Nc3ccc(OC(F)(F)Cl)cc3)cc2-c2cncnc2)C1 CHEMBL4113344 IC50 0.7 nM
N#Cc1cc(F)cc(-c2cc(C(=O)Nc3ccc(OC(F)(F)Cl)cc3)cnc2C2CC[C@@H](O)N2)c1 CHEMBL4111319 IC50 0.7 nM
N#Cc1ccc(F)c(-c2cc(C(=O)Nc3ccc(OC(F)(F)Cl)cc3)cnc2N2CC[C@@H](O)C2)c1 CHEMBL4111156 IC50 0.7 nM
N#Cc1ccc(-c2cc(C(=O)Nc3ccc(OC(F)(F)F)cc3)cnc2N2CC[C@@H](O)C2)[nH]1 CHEMBL4108980 IC50 0.7 nM
N#Cc1ccc(-c2cc(C(=O)Nc3ccc(OC(F)(F)Cl)cc3)cnc2N2CC[C@@H](O)C2)[nH]1 CHEMBL4114855 IC50 0.7 nM
O=C(Nc1ccc(OC(F)(F)Cl)cc1)c1ccc(N2C[C@H](O)[C@@H](O)C2)c(-c2ccn[nH]2)c1 CHEMBL3945273 IC50 0.7 nM
CO[C@H]1CN(c2ncc(C(=O)Nc3ccc(OC(F)(F)Cl)cc3)cc2-c2ccn[nH]2)C[C@@H]1N CHEMBL3922003 IC50 0.7 nM
O=C(Nc1ccc(OC(F)(F)Cl)cc1)c1cnc(N2CCC(O)CC2)c(-c2ccn[nH]2)c1 CHEMBL3984212 IC50 0.7 nM
CC1(O)CN(c2ncc(C(=O)Nc3ccc(OC(F)(F)Cl)cc3)cc2-c2[nH]ncc2F)C1 CHEMBL3942251 IC50 0.7 nM
O=C(Nc1ccc(OC(F)(F)Cl)cc1)c1cnc(N2CC[C@@H](O)C2)c(-c2[nH]ncc2F)c1 CHEMBL4213152 IC50 0.7 nM
Cc1ccc(C(=O)NC2CC(F)(F)C2)cc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3689738 Ki 0.706 nM
Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2c(cnn2C)c1 CHEMBL2316580 IC50 0.71 nM
O=C(Nc1cc2ccc(-c3cccnc3)cc2cn1)C1CC1 CHEMBL3689704 Ki 0.712 nM
CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3cc(C(C)(C)C)nn3-c3ccc4ncccc4c3)c(F)c2)ccn1 CHEMBL1738757 IC50 0.75 nM
CCc1ccccc1-c1ccc2nc(NC(=O)NCCN(C)C)sc2c1 CHEMBL2347731 IC50 0.77 nM
Cc1nc(Cl)ncc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3689691 Ki 0.789 nM
CC(O)Cn1cc(-c2cnc(N)c3c(-c4ccc(NC(=O)Nc5cccc(F)c5)cc4)csc23)cn1 CHEMBL2002165 pKi 0.7943 nM
C[C@@H](O)Cn1cc(-c2cnc(N)c3c(-c4ccc(NC(=O)Nc5cccc(F)c5)cc4)csc23)cn1 CHEMBL2022856 pKi 0.7943 nM
CC(C)Oc1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3685092 Ki 0.8 nM
O=C(Nc1cc2ccc(-c3cc(CO)ccc3F)cc2cn1)C1CC1 CHEMBL3685163 Ki 0.8 nM
CC(CO)Cc1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3685166 Ki 0.8 nM
Cc1cc(C(=O)Nc2ccc(C)c(-c3ccc4cc(NC(=O)C5CC5)ncc4c3)c2)ccn1 CHEMBL3685173 Ki 0.8 nM
Cc1ccc(C(=O)NC2CCOCC2)cc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3689582 Ki 0.8 nM
O=C(Nc1cc2c(Cl)nc(-c3ccccc3Cl)cc2cn1)C1CC1 CHEMBL3689635 Ki 0.8 nM
O=C(Nc1cc2c[n+]([O-])c(-c3ccccc3Cl)cc2cn1)C1CC1 CHEMBL3689640 Ki 0.8 nM
Cc1ccc(-c2cc(C(=O)Nc3ccc(OC(F)(F)F)cc3)cnc2N2CC[C@H](O)C2)cn1 CHEMBL3893997 IC50 0.8 nM
Cc1ccc(-c2cc(C(=O)Nc3ccc(OC(F)(F)F)cc3)cnc2N2CC[C@@H](O)C2)cn1 CHEMBL4114004 IC50 0.8 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(N2CC[C@@H](O)C2)c(-c2ccc(CO)nc2)c1 CHEMBL4112160 IC50 0.8 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(N2CC[C@@H](O)C2)c(-c2cnccc2F)c1 CHEMBL4112258 IC50 0.8 nM
Cc1ccc(-c2cc(C(=O)Nc3ccc(OC(F)(F)F)cc3)cnc2N2CC(CO)C2)cn1 CHEMBL3937265 IC50 0.8 nM
O=C(Nc1ccc(OC(F)(F)Cl)cc1)c1cnc(N2CC[C@H](O)C2)c(-c2cncnc2)c1 CHEMBL3900732 IC50 0.8 nM
CN(CCO)c1ncc(C(=O)Nc2ccc(OC(F)(F)Cl)cc2)cc1-c1cncnc1 CHEMBL3925052 IC50 0.8 nM
CCN(CCO)c1ncc(C(=O)Nc2ccc(OC(F)(F)Cl)cc2)cc1-c1cncc(C#N)c1 CHEMBL3953321 IC50 0.8 nM
N#Cc1cncc(-c2cc(C(=O)Nc3ccc(C(F)(F)C(F)(F)F)cc3)cnc2N2CC[C@@H](O)C2)c1 CHEMBL4110425 IC50 0.8 nM
CO[C@H]1CN(c2ncc(C(=O)Nc3ccc(OC(F)(F)Cl)cc3)cc2-c2cncc(F)c2)C[C@@H]1N CHEMBL3980432 IC50 0.8 nM
N#Cc1ccncc1-c1cc(C(=O)Nc2ccc(OC(F)(F)Cl)cc2)cnc1N1C[C@H](O)[C@@H](O)C1 CHEMBL3933733 IC50 0.8 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)c1ccc(N2CC[C@@H](O)C2)c(-c2cncs2)c1 CHEMBL4111774 IC50 0.8 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(N2CCCC2)c(-c2ccn[nH]2)c1 CHEMBL3923154 IC50 0.8 nM
CC1(O)CCN(c2ncc(C(=O)Nc3ccc(OC(F)(F)Cl)cc3)cc2-c2ccn[nH]2)C1 CHEMBL3926537 IC50 0.8 nM
CC1(O)CN(c2ncc(C(=O)Nc3ccc(OC(F)(F)Cl)cc3)cc2-c2ccn[nH]2)C1 CHEMBL3892152 IC50 0.8 nM
Cc1cc(-c2cc(C(=O)Nc3ccc(OC(F)(F)Cl)cc3)ccc2N2C[C@H](N)[C@@H](O)C2)[nH]n1 CHEMBL3962285 IC50 0.8 nM
O=C(Nc1ccc(OC(F)(F)Cl)cc1)c1cnc(N2CC(CO)C2)c(-c2[nH]ncc2F)c1 CHEMBL3925769 IC50 0.8 nM
O=C1Nc2cc(Br)ccc2/C1=C1/Nc2ccccc2/C1=N\OCCN1CCNCC1 CHEMBL3216659 IC50 0.87 nM
CCc1ccccc1-c1ccc2nc(NC(=O)NCCN3CCOCC3)sc2c1 CHEMBL2347730 IC50 0.89 nM
N#Cc1ncc(F)cc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3685014 Ki 0.9 nM
N#Cc1ccc(Cl)cc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3685067 Ki 0.9 nM
Cc1ccc(C(N)=O)cc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3685098 Ki 0.9 nM
Cc1ccc(F)cc1-c1ccc2c(Br)c(NC(=O)C3CC3)ncc2c1 CHEMBL3685103 Ki 0.9 nM
Cc1ccc(F)cc1-c1ccc2cc(NC(=O)CC3CC3)ncc2c1 CHEMBL3685118 Ki 0.9 nM
Cc1cc(N)ncc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3685154 Ki 0.9 nM
Cc1ccc(C(=O)NC2CCOC2)cc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3689613 Ki 0.9 nM
N[C@@H]1[C@H]2CN(c3ncc(C(=O)Nc4ccc(OC(F)(F)F)cc4)cc3-c3cncnc3)C[C@@H]12 CHEMBL3915545 IC50 0.9 nM
N#Cc1cncc(-c2cc(C(=O)Nc3ccc(OC(F)(F)F)cc3)cnc2N2CC[C@@H](O)C2)c1 CHEMBL4110615 IC50 0.9 nM
Nc1ncc(-c2cc(C(=O)Nc3ccc(OC(F)(F)F)cc3)cnc2N2CCCC2)cn1 CHEMBL3980913 IC50 0.9 nM
Cc1ccc(-c2cc(C(=O)Nc3ccc(OC(F)(F)F)cc3)cnc2N2CC[C@@H](CO)C2)cn1 CHEMBL4109606 IC50 0.9 nM
O=C(Nc1ccc(OC(F)(F)Cl)cc1)c1cnc(N2CC[C@H](CO)C2)c(-c2cncnc2)c1 CHEMBL3937661 IC50 0.9 nM
N#Cc1cncc(-c2cc(C(=O)Nc3ccc(SC(F)(F)F)cc3)cnc2N2CC[C@H](CO)C2)c1 CHEMBL3945801 IC50 0.9 nM
N#Cc1cncc(-c2cc(C(=O)Nc3ccc(OC(F)(F)F)c(F)c3)cnc2N2CC[C@H](CO)C2)c1 CHEMBL3973518 IC50 0.9 nM
Cc1ncncc1-c1cc(C(=O)Nc2ccc(OC(F)(F)Cl)cc2)cnc1N1C[C@@H](O)[C@H](O)C1 CHEMBL4110855 IC50 0.9 nM
CCN(CCO)c1ncc(C(=O)Nc2ccc(OC(F)(F)F)cc2)cc1-c1ccn[nH]1 CHEMBL3959733 IC50 0.9 nM
Cn1c(C#N)ccc1-c1cc(C(=O)Nc2ccc(OC(F)(F)Cl)cc2)cnc1N1CC[C@@H](O)C1 CHEMBL4112901 IC50 0.9 nM
CN(C)C1CN(c2ncc(C(=O)Nc3ccc(OC(F)(F)Cl)cc3)cc2-c2ccn[nH]2)C1 CHEMBL3952440 IC50 0.9 nM
COc1ccccc1-n1c(-c2cc(O)ccc2C)cn2c3c(=O)[nH]c(=O)n(C)c3nc12 CHEMBL566515 IC50 0.92 nM
Cc1ccc(C(=O)Nc2ccc(CN3CCCN(C)CC3)c(C(F)(F)F)c2)cc1-n1cc(-c2cnc3[nH]ncc3c2)nn1 CHEMBL2178268 IC50 0.94 nM
CCc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2[nH]ncc2c1 CHEMBL2316584 IC50 0.94 nM
Cc1ccc(Nc2ncc3c(n2)N(C)C(=O)N(c2cc(NC(=O)c4cccc(C(F)(F)F)c4)ccc2C)C3)cn1 CHEMBL1214141 IC50 0.97 nM
CN1CCN(Cc2ccc(NC(=O)c3ccc(Cl)c(-n4cc(-c5cnc6[nH]ncc6c5)nn4)c3)cc2C(F)(F)F)CC1 CHEMBL2178277 IC50 0.98 nM
Cc1cc(-c2cc(O)ccc2Br)cc2nnc(Nc3ccc(S(=O)(=O)NCCN4CCCC4)cc3)nc12 CHEMBL398279 Ki 1.0 nM
CC(C)n1nc(-c2ccc(Br)c(O)c2)c2c(N)ncnc21 CHEMBL1241578 IC50 1.0 nM
Cc1ccc(F)cc1-c1ccc2cc(NC(=O)C3CCC3)ncc2c1 CHEMBL3685002 Ki 1.0 nM
Nc1ccc(-c2ccc3cc(NC(=O)C4CC4)ncc3c2)cn1 CHEMBL3685012 Ki 1.0 nM
N#Cc1ccncc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3685013 Ki 1.0 nM
Cc1c(Cl)cccc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3685015 Ki 1.0 nM
Cc1cc(Cl)ccc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3685017 Ki 1.0 nM
Cc1ccc(F)cc1-c1ccc2cc(NC(=O)C3CCN(C)CC3)ncc2c1 CHEMBL3685031 Ki 1.0 nM
Cc1ncccc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3685036 Ki 1.0 nM
O=C(Nc1cc2ccc(-c3ccc4[nH]ccc4c3)cc2cn1)C1CC1 CHEMBL3685037 Ki 1.0 nM
Cc1ccc(F)cc1-c1ccc2cc(NC(=O)CN(C)C)ncc2c1 CHEMBL3685050 Ki 1.0 nM
Cc1ccc(F)cc1-c1ccc2cc(NC(=O)C(F)F)ncc2c1 CHEMBL3685069 Ki 1.0 nM
O=C(Nc1cc2ccc(Nc3ccccc3)cc2cn1)C1CC1 CHEMBL3685073 Ki 1.0 nM
Cc1ccc(N(C)C)cc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3685077 Ki 1.0 nM
Cc1ccc(F)cc1-c1ccc2cc(NC(=O)NC(C)C)ncc2c1 CHEMBL3685123 Ki 1.0 nM
Cc1nccnc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3685137 Ki 1.0 nM
CC(C)Cc1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3685148 Ki 1.0 nM
Cc1ccc(C(C)O)cc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3685160 Ki 1.0 nM
Cc1ccc(NC(=O)c2cnn(C)c2)cc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3685171 Ki 1.0 nM
O=C(Nc1cc2ccc(N3CCC(O)C3)cc2cn1)C1CC1 CHEMBL3685182 Ki 1.0 nM
CC(C)Sc1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3689550 Ki 1.0 nM
CC(C)[S+]([O-])c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3689551 Ki 1.0 nM
CC(C)S(=O)(=O)c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3689552 Ki 1.0 nM
O=C(Nc1cc2ccc(-c3cncc4[nH]ncc34)cc2cn1)C1CC1 CHEMBL3689583 Ki 1.0 nM
O=C(Nc1cc2ccc(-c3cccc4[nH]cnc34)cc2cn1)C1CC1 CHEMBL3689589 Ki 1.0 nM
Cc1ccc(C(=O)NC2COC2)cc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3689591 Ki 1.0 nM
Cc1ccc(C(=O)NC2(C)CCS(=O)(=O)C2)cc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3689611 Ki 1.0 nM
COCCNC(=O)c1ccc(C)c(-c2ccc3cc(NC(=O)C4CC4)ncc3c2)c1 CHEMBL3689614 Ki 1.0 nM
Cc1cncc(C)c1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3689618 Ki 1.0 nM
Cc1c(F)cc(C(=O)NC2COC2)cc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3689623 Ki 1.0 nM
Cc1ccc(C(=O)NC2COC2)c(F)c1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3689624 Ki 1.0 nM
Cc1ccc(C(=O)NC2CCOCC2)c(F)c1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3689625 Ki 1.0 nM
Cc1ccc(F)cc1-c1cc2cnc(NC(=O)C3CC3)cc2c(C#N)n1 CHEMBL3689650 Ki 1.0 nM
Cc1ccc(F)cc1-c1cc2cnc(NC(=O)C3CC3)cc2c(-c2cnccc2C)n1 CHEMBL3689663 Ki 1.0 nM
Cc1c2cc(NC(=O)C3CC3)ncc2cc(-c2ccccc2Cl)[n+]1[O-] CHEMBL3689669 Ki 1.0 nM
Cc1ccc(F)cc1-c1cc2cnc(NC(=O)C3CC3)cc2c(N2CCNCC2)n1 CHEMBL3689673 Ki 1.0 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(N2Cc3cn[nH]c3C2)c(-c2cncnc2)c1 CHEMBL3977220 IC50 1.0 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(N2CCNC3(CC3)C2)c(-c2cncnc2)c1 CHEMBL3894547 IC50 1.0 nM
NC1CN(c2ncc(C(=O)Nc3ccc(OC(F)(F)F)cc3)cc2-c2cncnc2)C1 CHEMBL3905480 IC50 1.0 nM
Cc1ncc(-c2cc(C(=O)Nc3ccc(OC(F)(F)Cl)cc3)ccc2N2C[C@H](O)[C@@H](O)C2)cn1 CHEMBL3964879 IC50 1.0 nM
O=C(Nc1ccc(OC(F)(F)Cl)cc1)c1cnc(N2C[C@H](CO)[C@@H](O)C2)c(-c2cncnc2)c1 CHEMBL4113112 IC50 1.0 nM
Cc1ncc(-c2cc(C(=O)Nc3ccc(OC(F)(F)F)cc3)cnc2N2CC[C@H](CO)C2)cn1 CHEMBL3914500 IC50 1.0 nM
CN(CCO)c1ncc(C(=O)Nc2ccc(OC(F)(F)F)cc2)cc1-c1cncc(F)c1 CHEMBL3960726 IC50 1.0 nM
O=C(Nc1ccc(SC(F)(F)F)cc1)c1cnc(N2CC[C@H](CO)C2)c(-c2cncnc2)c1 CHEMBL3911270 IC50 1.0 nM
N[C@H]1CN(c2ccc(C(=O)Nc3ccc(OC(F)(F)Cl)cc3)cc2-c2cncnc2)C[C@@H]1O CHEMBL3927811 IC50 1.0 nM
O=C(Nc1ccc(OC(F)(F)Cl)cc1)c1cnc(N2CC(CO)C2)c(-c2cncnc2)c1 CHEMBL3936682 IC50 1.0 nM
O=C(Nc1ccc(OC(F)(F)Cl)cc1)c1cnc(N2CC[C@@H](O)C2)c(-c2cc(F)cnc2Cl)c1 CHEMBL4108852 IC50 1.0 nM
Cc1ccc(F)cc1-c1cc(C(=O)Nc2ccc(OC(F)(F)Cl)cc2)cnc1N1C[C@H](O)[C@@H](O)C1 CHEMBL3949052 IC50 1.0 nM
CC(C)(C#N)c1ncc(C(=O)Nc2ccc(OC(F)(F)F)cc2)cc1-c1cncnc1 CHEMBL3981919 IC50 1.0 nM
C[C@]1(O)CCN(c2ncc(C(=O)Nc3ccc(OC(F)(F)F)cc3)cc2-c2ccn[nH]2)C1 CHEMBL3921587 IC50 1.0 nM
CCN(CCO)c1ncc(C(=O)Nc2ccc(OC(F)(F)Cl)cc2)cc1-c1ccn[nH]1 CHEMBL3984547 IC50 1.0 nM
O=C(Nc1ccc(OC(F)(F)Cl)cc1)c1cnc(N2CCNC3(CC3)C2)c(-c2ccn[nH]2)c1 CHEMBL3921088 IC50 1.0 nM
O=C(Nc1ccc(OC(F)(F)Cl)cc1)c1cnc(N2CCN(CC(F)(F)F)CC2)c(-c2ccn[nH]2)c1 CHEMBL3935476 IC50 1.0 nM
CN(CCO)c1ncc(C(=O)Nc2ccc(SC(F)(F)F)cc2)cc1-c1ccn[nH]1 CHEMBL3899209 IC50 1.0 nM
CCN(CCO)c1ncc(C(=O)Nc2ccc(SC(F)(F)F)cc2)cc1-c1ccn[nH]1 CHEMBL3900003 IC50 1.0 nM
C[C@]1(O)CCN(c2ncc(C(=O)Nc3ccc(OC(F)(F)Cl)cc3)cc2-c2ccn[nH]2)C1 CHEMBL3900626 IC50 1.0 nM
Cc1ccc(NC(=O)c2ccc(CN3CCN(C)CC3)cc2)cc1Nc1nccc(-c2cccnc2)n1 CHEMBL941 pKd 1.0 nM
Cc1nc(Nc2ncc(C(=O)Nc3c(Cl)ccnc3C)s2)cc(NN2CCN(CCO)CC2)n1 CHEMBL4855726 IC50 1.0 nM
Clc1cccc(Cl)c1-c1ccc2cc(Nc3ccnc(N4CCOCC4)n3)ncc2c1 CHEMBL3689710 Ki 1.03 nM
Cc1c(F)cncc1-c1cc2cnc(NC(=O)C3CC3F)cc2c[n+]1[O-] CHEMBL3689717 Ki 1.04 nM
CC(C)n1nc(C#Cc2cccc(C(=O)Nc3cccc(C(F)(F)F)c3)c2)c2c(N)ncnc21 CHEMBL3735207 IC50 1.1 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(N2CC[C@@H](O)C2)c(-c2cncc(F)c2)c1 CHEMBL4108721 IC50 1.1 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(N2CC[C@@H](O)C2)c(-c2cncc(Cl)c2)c1 CHEMBL4110946 IC50 1.1 nM
CO[C@H]1CN(c2ncc(C(=O)Nc3ccc(OC(F)(F)F)cc3)cc2-c2cncnc2)C[C@@H]1O CHEMBL3915759 IC50 1.1 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(N2CC[C@H](CO)C2)c(-c2ccc(CF)nc2)c1 CHEMBL3908533 IC50 1.1 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(N2CCC[C@@H](O)C2)c(-c2cncnc2)c1 CHEMBL4113119 IC50 1.1 nM
Cc1ccc(-c2cc(C(=O)Nc3ccc(OC(F)(F)F)cc3)cnc2N2CC(O)C2)cn1 CHEMBL3981125 IC50 1.1 nM
CC(C)(O)C1CN(c2ncc(C(=O)Nc3ccc(OC(F)(F)F)cc3)cc2-c2cccnc2)C1 CHEMBL3970905 IC50 1.1 nM
N#Cc1cncc(-c2cc(C(=O)Nc3ccc(SC(F)(F)F)c(F)c3)cnc2N2CC[C@@H](O)C2)c1 CHEMBL4108244 IC50 1.1 nM
N[C@@H]1CCCN(c2ncc(C(=O)Nc3ccc(OC(F)(F)Cl)cc3)cc2-c2cncnc2)C1 CHEMBL4113537 IC50 1.1 nM
O=C(Nc1ccc(OC(F)(F)Cl)cc1)c1cnc(N2CC(O)C2)c(-c2cncnc2)c1 CHEMBL3898364 IC50 1.1 nM
O=C(Nc1ccc(OC(F)(F)Cl)cc1)c1cnc(N2CC[C@@H](O)C2)c(-c2cc(F)cnc2F)c1 CHEMBL4108263 IC50 1.1 nM
Cc1ncc(-c2cc(C(=O)Nc3ccc(OC(F)(F)F)cc3)cnc2N2CC[C@H](CO)C2)s1 CHEMBL3897019 IC50 1.1 nM
NCC1(F)CCN(c2ncc(C(=O)Nc3ccc(OC(F)(F)Cl)cc3)cc2-c2ccn[nH]2)C1 CHEMBL3951432 IC50 1.1 nM
CN(C)C(=O)c1ccc(-c2cc(C(=O)Nc3ccc(OC(F)(F)Cl)cc3)cnc2N2CC[C@@H](O)C2)[nH]1 CHEMBL4115304 IC50 1.1 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(N2CC[C@@H](O)C2)c(-c2ccn[nH]2)c1 CHEMBL4217559 IC50 1.1 nM
Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1-n1cc(-c2cnc3[nH]ncc3c2)nn1 CHEMBL2177645 IC50 1.12 nM
Cc1ccncc1-c1ccc2cc(NC(=O)C3CCO3)ncc2c1 CHEMBL3689692 Ki 1.19 nM
Nc1ncnc2c1c(-c1ccc(Cl)c(O)c1)nn2C1CCCC1 CHEMBL1241676 IC50 1.2 nM
CN(C)Cc1cc(C(=O)N[C@@H]2CCc3ccc(Oc4ccnc5c4CCC(=O)N5)cc3C2)cc(C(F)(F)F)c1 CHEMBL1688860 IC50 1.2 nM
CC(C)Oc1cc(-n2cnc3ccc(N[C@@H](C)c4ccc(F)cn4)nc32)n[nH]1 CHEMBL2151321 IC50 1.2 nM
CCNC(=O)Nc1nc2ccc(-c3ccc(OC)cc3OC)cc2s1 CHEMBL2347720 IC50 1.2 nM
Cc1nc(Nc2nc3ccc(-c4cccc(C(=O)Nc5cccc(C(F)(F)F)c5)c4)nc3s2)cc(N2CCNCC2)n1 CHEMBL2148120 Kd 1.2 nM
CC(F)(F)Oc1ccc(NC(=O)c2cnc(N3CC[C@@H](O)C3)c(-c3cncnc3)c2)cc1 CHEMBL4108925 IC50 1.2 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)c1ccc(N2C[C@H](O)[C@@H](O)C2)c(-c2cncnc2)c1 CHEMBL3917328 IC50 1.2 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(N2CC[C@@H](O)C2)c(-c2cncnc2)c1 CHEMBL4115154 IC50 1.2 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(N2CC[C@@H](O)C2)c(-c2ccc(F)nc2)c1 CHEMBL4112036 IC50 1.2 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(N2CCC[C@H](O)C2)c(-c2cccnc2)c1 CHEMBL3910054 IC50 1.2 nM
CC1(O)CN(c2ncc(C(=O)Nc3ccc(OC(F)(F)F)cc3)cc2-c2cccnc2)C1 CHEMBL3933211 IC50 1.2 nM
O=C(Nc1ccc(OC(F)(F)F)c(F)c1)c1cnc(N2CC[C@@H](O)C2)c(-c2cncc(F)c2)c1 CHEMBL4110628 IC50 1.2 nM
N#Cc1cncc(-c2cc(C(=O)Nc3ccc(OC(F)(F)F)c(F)c3)cnc2N2CC[C@@H](O)C2)c1 CHEMBL4111003 IC50 1.2 nM
O=C(Nc1ccc(OC(F)(F)Cl)cc1)c1cnc(N2CC[C@@H](O)C2)c(-c2cc(F)nc(F)c2)c1 CHEMBL4108403 IC50 1.2 nM
O=C(Nc1ccc(OC(F)(F)Cl)cc1)c1cnc(OC2CCOCC2)c(-c2cncnc2)c1 CHEMBL3923412 IC50 1.2 nM
Cc1cc(-c2cc(C(=O)Nc3ccc(OC(F)(F)Cl)cc3)cnc2N2CC(CO)C2)[nH]n1 CHEMBL3922356 IC50 1.2 nM
Cc1cn(-c2cc(NC(=O)c3ccc(C)c(Nc4nccc(-c5cccnc5)n4)c3)cc(C(F)(F)F)c2)cn1 CHEMBL255863 IC50 1.2 nM
Cn1cc(NC(=O)c2cc(C(=O)c3c(Cl)ccc(Cl)c3F)c[nH]2)cn1 CHEMBL5193786 Kd 1.2 nM
Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1-n1cc(-c2cnc3[nH]ccc3c2)nn1 CHEMBL2177642 IC50 1.22 nM
CCCn1cc(-c2cnc(N)c3c(-c4ccc(NC(=O)Nc5cccc(F)c5)cc4)csc23)cn1 CHEMBL1993941 pKi 1.259 nM
Cc1cc(-c2c(Cl)ccc(O)c2F)cc2nnc(Nc3ccc(S(=O)(=O)NCCN4CCCC4)cc3)nc12 CHEMBL250821 Ki 1.3 nM
Cc1cc(-c2cc(O)ccc2Cl)cc2nnc(Nc3ccc(OCCN4CCCC4)cc3)nc12 CHEMBL400402 Ki 1.3 nM
Cc1ccc(-c2cc(C(=O)Nc3ccc(OC(F)(F)F)cc3)cnc2N2CC(C)(O)C2)cn1 CHEMBL3905198 IC50 1.3 nM
CN(CCO)c1ncc(C(=O)Nc2ccc(SC(F)(F)F)cc2)cc1-c1cncnc1 CHEMBL3906751 IC50 1.3 nM
O=C(Nc1ccc(OC(F)(F)C(F)(F)F)cc1)c1cnc(N2CC[C@@H](O)C2)c(-c2cncc(F)c2)c1 CHEMBL4115097 IC50 1.3 nM
Nc1ncc(-c2cc(C(=O)Nc3ccc(OC(F)(F)F)cc3)cnc2N2CC[C@@H](O)C2)cc1F CHEMBL4114006 IC50 1.3 nM
Cc1ncncc1-c1cc(C(=O)Nc2ccc(OC(F)(F)Cl)cc2)ccc1N1C[C@H](O)[C@@H](O)C1 CHEMBL3953095 IC50 1.3 nM
O=C(Nc1ccc(OC(F)(F)Cl)cc1)c1cnc(N2CCC3(CNC3)C2)c(-c2ccn[nH]2)c1 CHEMBL3923720 IC50 1.3 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(N2CC[C@@H](O)C2)c(-c2ccc[nH]2)c1 CHEMBL4108880 IC50 1.3 nM
O=C(Nc1ccc(OC(F)(F)Cl)cc1)c1cnc(N2CCC[C@@H](O)C2)c(-c2ccn[nH]2)c1 CHEMBL4110370 IC50 1.3 nM
Cn1cc(-c2cnc3c(-c4csc(C(=O)N[C@@H]5CCCC[C@@H]5N)c4)cnn3c2)cn1 CHEMBL4568087 IC50 1.3 nM
Cc1ccc(C(=O)Nc2ccc(CN3Cc4cn[nH]c4C3)c(Cl)c2)cc1C#Cc1cnc2cccnn12 CHEMBL4638981 IC50 1.3 nM
Cc1cc(-c2cc(Cl)ccc2O)cc2nnc(Nc3ccc(OCCN4CCCC4)cc3)nc12 CHEMBL5282737 Ki 1.3 nM
Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2ncnn2c1 CHEMBL2316581 IC50 1.33 nM
O=C(Nc1cc2ccc(-c3ccncc3Cl)cc2cn1)C1CC1 CHEMBL3689702 Ki 1.39 nM
Cn1c(=O)c(-c2c(Cl)cccc2Cl)cc2cnc(Nc3ccc(OC4OC(CO)C(O)C(O)C4O)cc3)nc21 CHEMBL585666 IC50 1.4 nM
COC(=O)c1cc2cc(NCc3c(C)cccc3Cl)cnc2[nH]1 CHEMBL3347388 IC50 1.4 nM
Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2ccccn12 CHEMBL1171086 IC50 1.4 nM
Nc1ncc(-c2cc(C(=O)Nc3ccc(OC(F)(F)F)cc3)cnc2N2CC[C@@H](O)C2)cn1 CHEMBL4111163 IC50 1.4 nM
N[C@@H]1CCN(c2ncc(C(=O)Nc3ccc(OC(F)(F)F)cc3)cc2-c2cncnc2)C1 CHEMBL4107355 IC50 1.4 nM
Cc1ncc(-c2cc(C(=O)Nc3ccc(OC(F)(F)F)cc3)cnc2N2CC(C)(O)C2)cc1F CHEMBL3939870 IC50 1.4 nM
CN(CCO)c1ncc(C(=O)Nc2ccc(SC(F)(F)F)cc2)cc1-c1cncc(C#N)c1 CHEMBL3897748 IC50 1.4 nM
CN(C)[C@H]1CN(c2ncc(C(=O)Nc3ccc(OC(F)(F)F)cc3)cc2-c2cncc(F)c2)C[C@@H]1O CHEMBL3912930 IC50 1.4 nM
N#Cc1ccncc1-c1cc(C(=O)Nc2ccc(OC(F)(F)F)cc2)cnc1N1CC[C@@H](O)C1 CHEMBL4107241 IC50 1.4 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(N2C[C@H](CO)[C@@H](O)C2)c(-c2cncs2)c1 CHEMBL4108670 IC50 1.4 nM
CN(C)[C@H]1CN(c2ncc(C(=O)Nc3ccc(OC(F)(F)Cl)cc3)cc2-c2ccn[nH]2)C[C@@H]1O CHEMBL3983162 IC50 1.4 nM
O=C(Nc1ccc(OC(F)(F)Cl)cc1)c1cnc(N2CCOCC2)c(-c2ccn[nH]2)c1 CHEMBL3918804 IC50 1.4 nM
N[C@H]1CN(c2ccc(C(=O)Nc3ccc(OC(F)(F)Cl)cc3)cc2-c2ccn[nH]2)C[C@@H]1O CHEMBL3920904 IC50 1.4 nM
Cc1cc(-c2cc(C(=O)Nc3ccc(OC(F)(F)Cl)cc3)cnc2N2CC(C)(O)C2)[nH]n1 CHEMBL3895420 IC50 1.4 nM
CC(C)(O)C1CCN(c2ncc(C(=O)Nc3ccc(OC(F)(F)F)cc3)cc2-c2cncnc2)C1 CHEMBL3902822 IC50 1.5 nM
CC1(O)CN(c2ncc(C(=O)Nc3ccc(OC(F)(F)F)cc3)cc2-c2cncc(F)c2)C1 CHEMBL3983928 IC50 1.5 nM
N#Cc1ccc(F)cc1-c1cc(C(=O)Nc2ccc(OC(F)(F)Cl)cc2)cnc1N1CC[C@@H](O)C1 CHEMBL4108311 IC50 1.5 nM
N[C@@H]1[C@H]2CN(c3ncc(C(=O)Nc4ccc(OC(F)(F)F)cc4)cc3-c3ccn[nH]3)C[C@@H]12 CHEMBL3905223 IC50 1.5 nM
CN(C)C1CN(c2ncc(C(=O)Nc3ccc(OC(F)(F)F)cc3)cc2-c2ccn[nH]2)C1 CHEMBL3958479 IC50 1.5 nM
O=C(Nc1ccc(OC(F)(F)Cl)cc1)c1cnc(N2CCC[C@H](O)C2)c(-c2ccn[nH]2)c1 CHEMBL3909037 IC50 1.5 nM
COCCOc1nc(Nc2ccc(P(C)(C)=O)cc2)c2ncn(/C=C/c3c(C)cccc3C)c2n1 CHEMBL461767 IC50 1.57 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(C)c5)cnc(N)c34)cc2)c1 CHEMBL1967116 pKi 1.585 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(-c5cn[nH]c5)cnc(N)c34)cc2)c1 CHEMBL1969102 pKi 1.585 nM
Nc1ncc(-c2cnn(CCO)c2)c2scc(-c3ccc(NC(=O)Nc4ccc(OC(F)F)cc4)cc3)c12 CHEMBL1972220 pKi 1.585 nM
Cc1cn(-c2cc(NC(=O)c3ccc(C)c(/C=C/n4cnc5c(N)ncnc54)c3)cc(C(F)(F)F)c2)cn1 CHEMBL1171679 IC50 1.6 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(N2CCC(F)(F)C2)c(-c2cncnc2)c1 CHEMBL3961140 IC50 1.6 nM
COC(=O)c1ccc(C(=O)Nc2ccc(OC(F)(F)F)cc2)cc1-c1cncnc1 CHEMBL3959861 IC50 1.6 nM
C[C@@]1(O)CCN(c2ncc(C(=O)Nc3ccc(OC(F)(F)F)cc3)cc2-c2ccn[nH]2)C1 CHEMBL4114922 IC50 1.6 nM
Cc1ccc(NC(=O)c2ccc(CN3CCN(C)CC3)cc2)cc1C#Cc1cnc2cccnn12 CHEMBL5172294 IC50 1.6 nM
Cc1cccc(C)c1/C=C/n1cnc2c(Nc3ccc(P(C)(C)=O)cc3)nc(-n3ccnc3)nc21 CHEMBL455384 IC50 1.63 nM
Cc1cc(-c2cc(O)ccc2Cl)cc2nnc(Nc3ccc(S(=O)(=O)CCCN4CCCC4)cc3)nc12 CHEMBL399268 Ki 1.7 nM
Cc1cc(-c2cc(O)ccc2Cl)cc2nnc(Nc3ccc(C(=O)N4CCNCC4)cc3)nc12 CHEMBL250214 Ki 1.7 nM
CCN(CCO)c1ncc(C(=O)Nc2ccc(OC(F)(F)F)cc2)cc1-c1cncnc1 CHEMBL3890630 IC50 1.7 nM
CO[C@H]1CN(c2ncc(C(=O)Nc3ccc(OC(F)(F)F)cc3)cc2-c2cncc(F)c2)C[C@@H]1N CHEMBL3952608 IC50 1.7 nM
Cc1cc(-c2cc(Cl)ccc2O)cc2nnc(Nc3ccc(C(=O)N4CCNCC4)cc3)nc12 CHEMBL5286051 Ki 1.7 nM
Cc1cc(-c2cc(Cl)ccc2O)cc2nnc(Nc3ccc(S(=O)(=O)CCCN4CCCC4)cc3)nc12 CHEMBL5266023 Ki 1.7 nM
Cc1cc([C@@H](O)C(F)(F)F)ncc1-c1cc2cnc(NC(=O)C3C[C@@H]3F)cc2cn1 CHEMBL3689742 Ki 1.71 nM
Cc1cc([C@@H](N)C(F)(F)F)ncc1-c1ccc2cc(NC(=O)C3C[C@@H]3F)ncc2c1 CHEMBL3689725 Ki 1.75 nM
Cc1cc([C@H](N)C(F)(F)F)ncc1-c1ccc2cc(NC(=O)C3C[C@@H]3F)ncc2c1 CHEMBL3689726 Ki 1.75 nM
COc1nc(Nc2ccc(P(C)(C)=O)cc2)c2ncn(/C=C/c3c(C)cccc3C)c2n1 CHEMBL509002 IC50 1.8 nM
O=C(Nc1ccc(OC(F)(F)Cl)cc1)c1cnc(N(CCO)CCO)c(-c2cncnc2)c1 CHEMBL3908742 IC50 1.8 nM
Cc1ccc(-c2cc(C(=O)Nc3ccc(OC(F)(F)F)cc3)ccc2N2C[C@H](O)[C@@H](O)C2)cn1 CHEMBL3936455 IC50 1.8 nM
CCN(CCO)c1ncc(C(=O)Nc2ccc(SC(F)(F)F)cc2)cc1-c1cncc(C#N)c1 CHEMBL3896686 IC50 1.8 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(N2C[C@@H](O)[C@@H](O)C2)c(-c2cncc(F)c2)c1 CHEMBL3890327 IC50 1.8 nM
O=C(Nc1ccc(OC(F)(F)Cl)cc1)c1cnc(N2CCC(F)(F)C2)c(-c2cncnc2)c1 CHEMBL3903657 IC50 1.9 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(N2CC(O)C2)c(-c2cncnc2)c1 CHEMBL3933980 IC50 1.9 nM
O=C(Nc1ccc(OC(F)(F)F)c(F)c1)c1cnc(N2CC[C@H](CO)C2)c(-c2cncnc2)c1 CHEMBL3951459 IC50 1.9 nM
NC12CC1CN(c1ncc(C(=O)Nc3ccc(OC(F)(F)F)cc3)cc1-c1cncnc1)C2 CHEMBL3891044 IC50 1.9 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)c1cccc(-n2ccnc2)c1 CHEMBL3981592 IC50 1.9 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(N2CC(O)C2)c(-c2ccn[nH]2)c1 CHEMBL3957410 IC50 1.9 nM
CN1CCN(Cc2ccc(NC(=O)c3ccc(Br)c(-n4cc(-c5cnc6[nH]ncc6c5)nn4)c3)cc2C(F)(F)F)CC1 CHEMBL2178278 IC50 1.94 nM
CNC(=O)C=Cc1cnc(N)c2c(-c3cc(F)c4[nH]c(C)cc4c3)csc12 CHEMBL2006778 pKi 1.995 nM
Cn1cc(-c2cnc(N)c3c(-c4ccc(NC(=O)Nc5cccc(F)c5)cc4)csc23)cn1 CHEMBL1970317 pKi 1.995 nM
COc1ccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(CC(O)CO)c5)cnc(N)c34)cc2)cc1 CHEMBL1965170 pKi 1.995 nM
CNC(=O)c1cnc(N)c2c(-c3ccc(NC(=O)Nc4cc(C)ccc4F)cc3)csc12 CHEMBL2005631 pKi 1.995 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1C(=O)Nc1cnc(Nc2ccc(N3CCN(C)CC3)cc2)nc1 CHEMBL272888 IC50 2.0 nM
Nc1ncnc2c1c(-c1cnc3[nH]ccc3c1)nn2C1CCCC1 CHEMBL1081312 IC50 2.0 nM
CCNC(=O)Nc1nc2ccc(-c3ccncc3)cc2s1 CHEMBL2347717 IC50 2.0 nM
Clc1ccccc1CNc1ncnc2c1cnn2CC(Cl)c1ccc(Br)cc1 CHEMBL2397805 Ki 2.0 nM
COc1ccc(Cl)cc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3685000 Ki 2.0 nM
O=C(Nc1cc2ccc(C3CCCCC3)cc2cn1)C1CC1 CHEMBL3685027 Ki 2.0 nM
O=C(Nc1cc2ccc(C3CCCC3)cc2cn1)C1CC1 CHEMBL3685029 Ki 2.0 nM
Cc1ccc(F)cc1-c1ccc2cc(NC(=O)C(C)(C)C)ncc2c1 CHEMBL3685043 Ki 2.0 nM
O=C(Nc1cc2ccc(-c3ccccn3)cc2cn1)C1CC1 CHEMBL3685047 Ki 2.0 nM
Cc1cnccc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3685078 Ki 2.0 nM
Cc1ncnc(C)c1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3685081 Ki 2.0 nM
Cn1nccc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3685084 Ki 2.0 nM
Cc1ccc(F)cc1-c1ccc2c(Cl)c(NC(=O)C3CC3)ncc2c1 CHEMBL3685100 Ki 2.0 nM
Cc1ccc(F)cc1-c1ccc2cc(NC(=O)C3CCNCC3)ncc2c1 CHEMBL3685111 Ki 2.0 nM
CCN1CCC(C(=O)Nc2cc3ccc(-c4cc(F)ccc4C)cc3cn2)CC1 CHEMBL3685113 Ki 2.0 nM
Cc1ccncc1-c1ccc2cc(NC(=O)C3CCN(C)CC3)ncc2c1 CHEMBL3685114 Ki 2.0 nM
Cc1ccc(C)c(-c2ccc3cc(NC(=O)C4CC4)ncc3c2)c1 CHEMBL3685130 Ki 2.0 nM
C[C@@H](CO)Oc1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3685158 Ki 2.0 nM
O=C(Nc1cc2ccc(-c3cccc(CO)c3)cc2cn1)C1CC1 CHEMBL3685161 Ki 2.0 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3685175 Ki 2.0 nM
C[C@@H](CCO)Oc1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3685194 Ki 2.0 nM
O=C(Nc1ccc(Cl)c(-c2ccc3cc(NC(=O)C4CC4)ncc3c2)c1)C1CCOCC1 CHEMBL3685195 Ki 2.0 nM
COc1cc(C)c(-c2ccc3cc(NC(=O)C4CC4)ncc3c2)cn1 CHEMBL3689555 Ki 2.0 nM
Cc1nc(N)ncc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3689560 Ki 2.0 nM
O=C(Nc1cc2ccc(OC3CCC[C@@H]3O)cc2cn1)C1CC1 CHEMBL3689569 Ki 2.0 nM
Cc1cnc(F)cc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3689580 Ki 2.0 nM
COCC(=O)Nc1ccc(C)c(-c2ccc3cc(NC(=O)C4CC4)ncc3c2)c1 CHEMBL3689585 Ki 2.0 nM
CO[C@@H](C)C(=O)Nc1ccc(C)c(-c2ccc3cc(NC(=O)C4CC4)ncc3c2)c1 CHEMBL3689587 Ki 2.0 nM
COc1ccncc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3689598 Ki 2.0 nM
Cc1ccc(NC(=O)N2CCS(=O)(=O)CC2)cc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3689601 Ki 2.0 nM
Cc1c(F)cc(NC(=O)C2CCC2)cc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3689626 Ki 2.0 nM
Cc1ccc(C(=O)NC2(C)COC2)cc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3689629 Ki 2.0 nM
COc1nc(-c2ccccc2Cl)cc2cnc(NC(=O)C3CC3)cc12 CHEMBL3689641 Ki 2.0 nM
O=C(Nc1cc2c(C3CC3)nc(-c3ccccc3Cl)cc2cn1)C1CC1 CHEMBL3689643 Ki 2.0 nM
O=C(Nc1cc2cnc(C3CCCCC3)cc2cn1)C1CC1 CHEMBL3689644 Ki 2.0 nM
Cc1ccc(F)cc1-c1cc2cnc(NC(=O)C3CC3)cc2c(OC2CCNC2)n1 CHEMBL3689675 Ki 2.0 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(N2C[C@@H](O)[C@@H](O)C2)c(-c2cncnc2)c1 CHEMBL3919800 IC50 2.0 nM
CN(C)[C@H]1CN(c2ncc(C(=O)Nc3ccc(OC(F)(F)F)cc3)cc2-c2cncnc2)C[C@@H]1O CHEMBL3892160 IC50 2.0 nM
NC1CN(c2ncc(C(=O)Nc3ccc(OC(F)(F)F)cc3)cc2-c2cncc(F)c2)C1 CHEMBL3932037 IC50 2.0 nM
CCN(CCO)c1ncc(C(=O)Nc2ccc(OC(F)(F)F)cc2)cc1-c1cncc(F)c1 CHEMBL3915104 IC50 2.0 nM
COc1ncc(-c2cc(C(=O)Nc3ccc(OC(F)(F)Cl)cc3)cnc2N2CC[C@@H](O)C2)c(OC)n1 CHEMBL4107033 IC50 2.0 nM
Cc1cc(-c2cc(C(=O)Nc3ccc(OC(F)(F)F)cc3)cnc2N2CC(CO)C2)[nH]n1 CHEMBL3951572 IC50 2.0 nM
O=C(Nc1ccc(OC(F)(F)Cl)cc1)c1cnc(N2CC3(CNC3)C2)c(-c2ccn[nH]2)c1 CHEMBL3897561 IC50 2.0 nM
Cc1ccc(NC(=O)c2ccc(C)c(C(F)(F)F)c2)cc1C#Cc1nn([C@H]2CC[C@H](O)CC2)c2ncnc(N)c12 CHEMBL4798527 IC50 2.0 nM
Cc1cc(-c2c(Cl)cccc2Cl)cc2nnc(Nc3ccc(OCC[N+]4([O-])CCCC4)cc3)nc12 CHEMBL256101 Ki 2.04 nM
Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2[nH]nc(-c3ccccc3)c2c1 CHEMBL2316871 IC50 2.06 nM
Cc1cc(C(C)(C)O)ncc1-c1ccc2cc(NC(=O)[C@@H]3C[C@@H]3F)ncc2c1 CHEMBL3689739 Ki 2.08 nM
Cc1ccc(NC(=O)c2ccc(CN3CCN(C)CC3)cc2)cc1Nc1nc(-c2cccnc2)cs1 CHEMBL1908391 Kd 2.1 nM
COC(=O)c1cc(F)cc(-c2cc(C(=O)Nc3ccc(OC(F)(F)F)cc3)cnc2N2CC[C@@H](O)C2)c1 CHEMBL4113011 IC50 2.1 nM
Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2[nH]ccc2n1 CHEMBL3974327 IC50 2.12 nM
CN1CCN(Cc2ccc(NC(=O)c3ccc(C4CC4)c(C#Cc4cnc5[nH]ncc5c4)c3)cc2C(F)(F)F)CC1 CHEMBL2316585 IC50 2.16 nM
Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1-n1cc(-c2cnc3[nH]nc(C)c3c2)nn1 CHEMBL2177646 IC50 2.18 nM
Cc1ccc(NC(=O)c2ccc3c(c2)CC[C@@H]3N2CCN(C)CC2)cc1Nc1nccc(-c2cccnc2)n1 CHEMBL3690082 IC50 2.2 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)c1ccc(N2C[C@@H](O)[C@@H](O)C2)c(-c2cncnc2)c1 CHEMBL3907269 IC50 2.2 nM
CNc1nc2cc(C#Cc3cc(C(=O)Nc4ccc(CN5CCN(C)CC5)c(C(F)(F)F)c4)ccc3C)ccn2n1 CHEMBL3898824 IC50 2.28 nM
Cn1c(=O)c(-c2c(Cl)cccc2Cl)cc2cnc(Nc3ccc(NCC(O)CO)cc3)nc21 CHEMBL567068 IC50 2.3 nM
Cn1c(=O)c(-c2c(Cl)cccc2Cl)cc2cnc(Nc3ccc(N)cc3)nc21 CHEMBL566636 IC50 2.3 nM
Cc1ccc(C(=O)Nc2cc(-n3ccnc3)cc(C(F)(F)F)c2)cc1C#Cc1cnc2c(N)cccn12 CHEMBL1172397 IC50 2.3 nM
Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cnccn12 CHEMBL1171836 IC50 2.3 nM
Cc1ccc(C(=O)Nc2ccc(CN3CCNCC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12 CHEMBL1173352 IC50 2.3 nM
CCNC(=O)Nc1nc2ccc(-c3ccccc3OCC)cc2[nH]1 CHEMBL2347741 IC50 2.3 nM
CN[C@H]1CCN(c2ncc(C(=O)Nc3ccc(OC(F)(F)F)cc3)cc2-c2cncnc2)C1 CHEMBL3896423 IC50 2.3 nM
CC1(O)CN(c2ncc(C(=O)Nc3ccc(OC(F)(F)F)cc3)cc2-c2cncnc2)C1 CHEMBL3920051 IC50 2.3 nM
O=C(Nc1ccc(OC(F)(F)C(F)(F)F)cc1)c1cnc(N2CC[C@@H](O)C2)c(-c2cncnc2)c1 CHEMBL4114156 IC50 2.3 nM
Cc1ncc(C(=O)Nc2ccc(OC(F)(F)F)cc2)cc1-c1cncnc1 CHEMBL3945358 IC50 2.3 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(N2CC[C@H](O)C2)c(-c2cncnc2)c1 CHEMBL3954214 IC50 2.3 nM
CP(C)(=O)c1ccc(Nc2ncnc3c2ncn3/C=C/c2cccc3[nH]ncc23)cc1 CHEMBL452563 IC50 2.36 nM
Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(Cl)c2)cc1C#Cc1cnc2cccnn12 CHEMBL1172718 IC50 2.4 nM
Cc1ccc(NC(=O)c2ccc3c(c2)CCC3N2CCN(C)CC2)cc1Nc1nccc(-c2cncnc2)n1 CHEMBL3690079 IC50 2.4 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(N2CCCOCC2)c(-c2cncnc2)c1 CHEMBL3902865 IC50 2.4 nM
N[C@H]1CN(c2ncc(C(=O)Nc3ccc(OC(F)(F)Cl)cc3)cc2-c2cncc(F)c2)C[C@@H]1O CHEMBL3906897 IC50 2.4 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)c1ccc(N2CC[C@@H](O)C2)c(-c2cncnc2)c1 CHEMBL4110566 IC50 2.4 nM
O=C(Nc1ccc(OC(F)(F)Cl)cc1)c1cnc(N2CC[C@@H](O)C2)c(-c2ccc[nH]2)c1 CHEMBL4110588 IC50 2.4 nM
O=C(Nc1ccc(OC(F)(F)Cl)cc1)c1cnc(N2CCN(CCF)CC2)c(-c2ccn[nH]2)c1 CHEMBL3947817 IC50 2.4 nM
CN1CCN(c2nccc(Nc3cc4ccc(-c5c(Cl)cccc5Cl)cc4cn3)n2)CC1 CHEMBL3689709 Ki 2.42 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(N2CCOCC2)c(-c2cnccn2)c1 CHEMBL3908795 IC50 2.5 nM
Cn1cc(-c2cnc(N)c3c(-c4ccc(NC(=O)Nc5ccc(OC(F)F)cc5)cc4)csc23)cn1 CHEMBL1988387 pKi 2.512 nM
CCN(CC)CCNC(=O)C=Cc1cnc(N)c2c(-c3ccc(NC(=O)Nc4cccc(C)c4)cc3)csc12 CHEMBL2004716 pKi 2.512 nM
Cc1ccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(C)c5)cnc(N)c34)cc2)cc1 CHEMBL1982466 pKi 2.512 nM
COC(C(=O)N1Cc2[nH]nc(NC(=O)c3ccc(N4CCN(C)CC4)cc3)c2C1)c1ccccc1 CHEMBL1981047 pKi 2.512 nM
Cc1cc([C@H](O)C(F)(F)F)ncc1-c1cc2cnc(NC(=O)C3C[C@@H]3F)cc2cn1 CHEMBL3689741 Ki 2.55 nM
Cc1cc(-c2cc(O)ccc2Cl)cc2nnc(Nc3ccc(C(=O)NCCN4CCCC4)cc3)nc12 CHEMBL400403 Ki 2.6 nM
Cn1c(=O)c(-c2c(Cl)cccc2Cl)cc2cnc(Nc3cccc(O)c3)nc21 CHEMBL321193 IC50 2.6 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(N2CCOCC2)c(-c2ccc(CO)nc2)c1 CHEMBL3979129 IC50 2.6 nM
CN(C)C1CN(c2ncc(C(=O)Nc3ccc(OC(F)(F)F)cc3)cc2-c2cncc(F)c2)C1 CHEMBL3904036 IC50 2.6 nM
O=C(Nc1ccc(SC(F)(F)F)cc1)c1cnc(N2CC[C@@H](O)C2)c(-c2ccc[nH]2)c1 CHEMBL4106490 IC50 2.6 nM
Cc1cc(-c2cc(Cl)ccc2O)cc2nnc(Nc3ccc(C(=O)NCCN4CCCC4)cc3)nc12 CHEMBL5269803 Ki 2.6 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)c1ccc(N2CC[C@@H](O)C2)c(-c2cccnc2)c1 CHEMBL4109691 IC50 2.7 nM
CN(CCO)c1ncc(C(=O)Nc2ccc(OC(F)(F)Cl)cc2)cc1-c1ccn[nH]1 CHEMBL3985022 IC50 2.7 nM
Cc1c(F)cncc1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)sc2c1 CHEMBL4862702 IC50 2.71 nM
COc1n[nH]c2ncc(C#Cc3cc(C(=O)Nc4ccc(CN5CCN(C)CC5)c(C(F)(F)F)c4)ccc3C)cc12 CHEMBL2316872 IC50 2.72 nM
Cc1cccc(Cl)c1/C=C/n1cnc2c(Nc3ccc(P(C)(C)=O)cc3)ncnc21 CHEMBL454611 IC50 2.77 nM
Cn1c(=O)c(-c2c(Cl)cccc2Cl)cc2cnc(Nc3cccc(CO)c3)nc21 CHEMBL327127 IC50 2.8 nM
CCCOc1ccccc1-c1ccc2nc(NC(=O)NCC)sc2c1 CHEMBL2347713 IC50 2.8 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)c1ccc(N2C[C@H](O)[C@@H](O)C2)c(-c2cccnc2)c1 CHEMBL3908507 IC50 2.8 nM
N[C@H]1CCN(c2ncc(C(=O)Nc3ccc(OC(F)(F)F)cc3)cc2-c2cncnc2)C1 CHEMBL3890279 IC50 2.8 nM
CCN(CCO)c1ncc(C(=O)Nc2ccc(OC(F)(F)F)cc2)cc1-c1cncc(C#N)c1 CHEMBL3919275 IC50 2.8 nM
CC(F)(F)Oc1ccc(NC(=O)c2cnc(N3CC[C@@H](O)C3)c(-c3cncc(F)c3)c2)cc1 CHEMBL4113279 IC50 2.8 nM
COc1cc2ncnc(Oc3cccc(NC(=O)Nc4cc(C(C)(C)C(F)(F)F)on4)c3)c2cc1OC CHEMBL2029988 Kd 2.8 nM
Cc1cc(-c2cc(O)ccc2Cl)cc2nnc(Nc3ccc(S(=O)(=O)N(CCN4CCCC4)C(C)C)cc3)nc12 CHEMBL250218 Ki 2.9 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL388978 Kd 2.9 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(N2CC[C@@H](O)C2)c(-c2ccc(C(F)(F)F)nc2)c1 CHEMBL4108985 IC50 2.9 nM
O=C(Nc1ccc(OC(F)(F)Cl)cc1)c1cnc(Cl)c(-c2cncnc2)c1 CHEMBL3972135 IC50 2.9 nM
Cc1n[nH]c2ccc(-c3cc(N[C@@H](CO)c4ccccc4)cnc3-c3cc(F)ccc3O)cc12 CHEMBL4062877 IC50 2.9 nM
Cc1cc(-c2cc(Cl)ccc2O)cc2nnc(Nc3ccc(S(=O)(=O)N(CCN4CCCC4)C(C)C)cc3)nc12 CHEMBL5272285 Ki 2.9 nM
COc1cc2[nH]nc(-c3nc4cc(N5CCC(N6CCCCC6)CC5)ccc4[nH]3)c2cc1OCc1ccccc1 CHEMBL210827 IC50 3.0 nM
Cc1cc(-c2cc(O)ccc2Cl)cc2nnc(Nc3ccc(S(=O)(=O)NCCN4CCCC4)cc3)nc12 CHEMBL249821 Ki 3.0 nM
Cc1cc(Nc2cc(N3CCN(C)CC3)nc(Sc3ccc(NC(=O)C4CC4)cc3)n2)n[nH]1 CHEMBL572878 Kd 3.0 nM
CN1CCN(Cc2ccc(-c3cnc4[nH]cc(-c5ccc6[nH]ccc6c5)c4c3)cc2)CC1 CHEMBL2436978 IC50 3.0 nM
CC(C)n1nc(/C=C/c2cccc(O)c2)c2c(N)ncnc21 CHEMBL3735312 IC50 3.0 nM
Cc1cnc(C)c(-c2ccc3cc(NC(=O)C4CC4)ncc3c2)c1 CHEMBL3685011 Ki 3.0 nM
Cn1cc(-c2ccc3cc(NC(=O)C4CC4)ncc3c2)cn1 CHEMBL3685021 Ki 3.0 nM
Cc1n[nH]c(C)c1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3685022 Ki 3.0 nM
Cc1ccc(F)cc1-c1ccc2cc(NC(=O)C3CCOCC3)ncc2c1 CHEMBL3685030 Ki 3.0 nM
O=C(Nc1cc2ccc(N3CCC(O)CC3)cc2cn1)C1CC1 CHEMBL3685038 Ki 3.0 nM
Cc1ccc(F)cc1-c1ccc2cc(NC(=O)CC(F)(F)F)ncc2c1 CHEMBL3685042 Ki 3.0 nM
COc1cccc(C#N)c1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3685046 Ki 3.0 nM
Cc1ccc(F)cc1-c1ccc2cc(NC(=O)N(C)C)ncc2c1 CHEMBL3685079 Ki 3.0 nM
O=C(Nc1cc2ccc(Oc3ccccc3)cc2cn1)C1CC1 CHEMBL3685104 Ki 3.0 nM
Cc1ccc(F)cc1-c1ccc2cc(NC(=O)C3CCN(C)C3)ncc2c1 CHEMBL3685112 Ki 3.0 nM
CC(C)=Cc1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3685145 Ki 3.0 nM
Cc1ncc(CO)cc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3685156 Ki 3.0 nM
COC(C)(C)C(=O)Nc1ccc(C)c(-c2ccc3cc(NC(=O)C4CC4)ncc3c2)c1 CHEMBL3689590 Ki 3.0 nM
CCS(=O)(=O)Nc1ccc(C)c(-c2ccc3cc(NC(=O)C4CC4)ncc3c2)c1 CHEMBL3689593 Ki 3.0 nM
Cc1cc(C(=O)O)ncc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3689621 Ki 3.0 nM
Cc1ccc(F)cc1-c1cc2cnc(NC(=O)C3CC3)cc2c(N2CCCCC2)n1 CHEMBL3689651 Ki 3.0 nM
O=C(Nc1cc2ccc(-c3ccccc3Cl)nc2cn1)C1CC1 CHEMBL3689684 Ki 3.0 nM
COc1ncc(-c2cc(C(=O)Nc3ccc(OC(F)(F)F)cc3)cnc2N2CC[C@@H](O)C2)cn1 CHEMBL4110752 IC50 3.0 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(N2CC[C@@H](O)C2)c(-c2cccnc2F)c1 CHEMBL4115674 IC50 3.0 nM
COc1cncc(-c2cc(C(=O)Nc3ccc(OC(F)(F)F)cc3)cnc2N2CC[C@@H](O)C2)c1 CHEMBL4108749 IC50 3.0 nM
CN[C@H]1CCN(c2ncc(C(=O)Nc3ccc(OC(F)(F)F)cc3)cc2-c2ccc(C)nc2)C1 CHEMBL3896105 IC50 3.0 nM
Cc1ccc(-c2cc(C(=O)Nc3ccc(OC(F)(F)F)cc3)cnc2N2CCC[C@H](O)C2)cn1 CHEMBL3897453 IC50 3.0 nM
N#Cc1cncc(-c2cc(C(=O)Nc3ccc(OC(F)(F)Cl)cc3)cnc2N2CC[C@@H](O)C2)c1 CHEMBL4107599 IC50 3.0 nM
CCN(CCO)c1ncc(C(=O)Nc2ccc(SC(F)(F)F)cc2)cc1-c1cncnc1 CHEMBL3968914 IC50 3.0 nM
Cc1ncncc1-c1cc(C(=O)Nc2ccc(OC(F)(F)Cl)cc2)cnc1N1CC[C@@H](O)C1 CHEMBL4114621 IC50 3.0 nM
O=C(Nc1ccc(OC(F)(F)Cl)cc1)c1cnc(N2C[C@H](O)[C@@H](O)C2)c(-c2cncc(F)c2)c1 CHEMBL3943826 IC50 3.0 nM
CC(F)(F)Oc1ccc(NC(=O)c2cnc(N3CC[C@@H](O)C3)c(-c3cncc(C#N)c3)c2)cc1 CHEMBL4109719 IC50 3.0 nM
O=C(Nc1ccc(SC(F)(F)F)nc1)c1cnc(N2CC[C@@H](O)C2)c(-c2cncnc2)c1 CHEMBL4108470 IC50 3.0 nM
Cc1ccc(F)cc1-c1cc(C(=O)Nc2ccc(OC(F)(F)Cl)cc2)cnc1N1CC[C@@H](O)C1 CHEMBL4114635 IC50 3.0 nM
COc1ncc(-c2cc(C(=O)Nc3ccc(OC(F)(F)F)cc3)ccc2C)cn1 CHEMBL3893615 IC50 3.0 nM
Cc1ccc(C(=O)Nc2ccc(OC(F)(F)F)cc2)cc1-c1cncs1 CHEMBL3950377 IC50 3.0 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(C2CCOCC2)c(-c2cncnc2)c1 CHEMBL3917389 IC50 3.0 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)c1ccc(N2C[C@H](O)[C@@H](O)C2)c(-c2cncs2)c1 CHEMBL3962900 IC50 3.0 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)c1ccc(N2C[C@H](O)[C@@H](O)C2)c(-c2ccc[nH]2)c1 CHEMBL3971478 IC50 3.0 nM
NC12CC1CN(c1ncc(C(=O)Nc3ccc(OC(F)(F)F)cc3)cc1-c1ccn[nH]1)C2 CHEMBL3979517 IC50 3.0 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(N2CC(CO)C2)c(-c2ccn[nH]2)c1 CHEMBL3930961 IC50 3.0 nM
N[C@@H]1CN(c2ncc(C(=O)Nc3ccc(OC(F)(F)Cl)cc3)cc2-c2ccn[nH]2)C[C@H]1F CHEMBL4110627 IC50 3.0 nM
O=C(Nc1ccc(OC(F)(F)Cl)cc1)c1cnc(N2CCCC3(CCN3)C2)c(-c2ccn[nH]2)c1 CHEMBL3962922 IC50 3.0 nM
CC(C)n1nc(C#Cc2cccc3cc(-c4cccc(C(F)(F)F)c4)ncc23)c2c(N)ncnc21 CHEMBL4247506 IC50 3.0 nM
Cc1cc(-c2cc(Cl)ccc2O)cc2nnc(Nc3ccc(S(=O)(=O)NCCN4CCCC4)cc3)nc12 CHEMBL5280331 Ki 3.0 nM
Cc1cccc(C)c1/C=C/n1cnc2c(Nc3ccc(P(C)(C)=O)cc3)nc(N3CCOCC3)nc21 CHEMBL454358 IC50 3.02 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)c1cccc(-c2cnccn2)c1 CHEMBL3978018 IC50 3.1 nM
Cc1ccc(C(=O)Nc2ccc(CN3CCC4C=NNC4C3)c(Cl)c2)cc1C#Cc1cnc2cccnn12 CHEMBL4640297 IC50 3.1 nM
COc1ccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(CC(C)(C)O)c5)cnc(N)c34)cc2)cc1 CHEMBL2004290 pKi 3.162 nM
CNC(=O)c1ccccc1Sc1ccc2c(C=Cc3ccccn3)n[nH]c2c1 CHEMBL1988437 pKi 3.162 nM
Nc1ncc(-c2cnn(CCO)c2)c2scc(-c3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12 CHEMBL1980297 pKi 3.162 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)c1ccc(F)c(-c2cncnc2)c1 CHEMBL3890053 IC50 3.2 nM
COc1ccc(C(=O)Nc2ccc(OC(F)(F)F)cc2)cc1-c1cccnc1 CHEMBL3941523 IC50 3.2 nM
CC1(O)CCN(c2ncc(C(=O)Nc3ccc(OC(F)(F)F)cc3)cc2-c2cncnc2)C1 CHEMBL3928824 IC50 3.3 nM
O=C(Nc1ccc(SC(F)F)cc1)c1cnc(N2CC[C@@H](O)C2)c(-c2cncnc2)c1 CHEMBL4107125 IC50 3.3 nM
COC(=O)c1cc(-c2cccc(C(=O)Nc3ccc(OC(F)(F)F)cc3)c2)cs1 CHEMBL3970195 IC50 3.3 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(N2CCCC2)c(-c2cc(CO)n[nH]2)c1 CHEMBL3952900 IC50 3.3 nM
O=C(Nc1ccc(OC(F)(F)Cl)cc1)c1cnc(N2CCN(CC(F)F)CC2)c(-c2ccn[nH]2)c1 CHEMBL3973884 IC50 3.3 nM
Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCNCC2)n1 CHEMBL4538000 Ki 3.3 nM
Cc1cc(-c2c(F)ccc(O)c2F)cc2nnc(Nc3ccc(S(=O)(=O)NCCN4CCCC4)cc3)nc12 CHEMBL440963 Ki 3.4 nM
Cc1cc(NC(=O)c2ccc(C)c(Nc3nccc(-c4cccnc4)n3)c2)cc(-n2cnc(C)c2)c1 CHEMBL2311806 Kd 3.4 nM
COc1ccc(C(=O)Nc2ccc(OC(F)(F)F)cc2)cc1-c1ccc(F)nc1 CHEMBL3964661 IC50 3.4 nM
COc1ccc(C(=O)Nc2ccc(OC(F)(F)F)cc2)cc1-c1ccc(C(C)=O)s1 CHEMBL3922918 IC50 3.4 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)c1cccc(-c2cncnc2)c1 CHEMBL3956542 IC50 3.4 nM
O=C(Nc1ccc(OC(F)(F)Cl)cc1)c1cnc(N2CCN(C3CC3)CC2)c(-c2ccn[nH]2)c1 CHEMBL3954059 IC50 3.4 nM
Cc1cc([C@H](O)C(F)(F)F)ncc1-c1ccc2cc(NC(=O)C(C)C)ncc2c1 CHEMBL3689733 Ki 3.46 nM
Cc1cc([C@@H](O)C(F)(F)F)ncc1-c1ccc2cc(NC(=O)C(C)C)ncc2c1 CHEMBL3689734 Ki 3.46 nM
CCN(CC)CCN1CCC(S(=O)(=O)c2ccc(Nc3nnc4cc(-c5cc(O)ccc5Cl)cc(C)c4n3)cc2)CC1 CHEMBL398845 Ki 3.5 nM
Cc1cc(-c2cc(O)ccc2Cl)cc2nnc(Nc3ccc(S(=O)(=O)C4CCNCC4)cc3)nc12 CHEMBL250625 Ki 3.5 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(N2CC[C@@H](O)C2)c(-c2cc(F)cnc2F)c1 CHEMBL4109332 IC50 3.5 nM
C[C@]1(O)CCN(c2ncc(C(=O)Nc3ccc(OC(F)(F)F)cc3)cc2-c2cncnc2)C1 CHEMBL3909820 IC50 3.5 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(N2CCC3(COC3)C2)c(-c2cncnc2)c1 CHEMBL3954083 IC50 3.5 nM
Nc1ncc(-c2cncc(C(=O)Nc3ccc(OC(F)(F)F)cc3)c2)cn1 CHEMBL3979039 IC50 3.5 nM
Cc1ccc(C(=O)Nc2ccc(OC(F)(F)F)cc2)cc1-c1cncnc1 CHEMBL3935043 IC50 3.5 nM
CC1(O)CCN(c2ccc(C(=O)Nc3ccc(OC(F)(F)F)cc3)cc2-c2cncs2)C1 CHEMBL3893954 IC50 3.5 nM
CCn1nc(C#Cc2cccc3cc(-c4cccc(C(F)(F)F)c4)ncc23)c2c(N)ncnc21 CHEMBL4248365 IC50 3.5 nM
Cc1cc(-c2cc(Cl)ccc2O)cc2nnc(Nc3ccc(S(=O)(=O)C4CCNCC4)cc3)nc12 CHEMBL5274378 Ki 3.5 nM
CCN(CC)CCN1CCC(S(=O)(=O)c2ccc(Nc3nnc4cc(-c5cc(Cl)ccc5O)cc(C)c4n3)cc2)CC1 CHEMBL5270142 Ki 3.5 nM
Cc1cccc(C)c1/C=C/n1cnc2c(Nc3ccc(P(C)(C)=O)cc3)ncnc21 CHEMBL488840 IC50 3.58 nM
CN1CCN(C(=O)c2ccc(Nc3ncc4cc(-c5c(Cl)cccc5Cl)c(=O)n(C)c4n3)cc2)CC1 CHEMBL565366 IC50 3.6 nM
Cc1ccc(C(=O)Nc2ccc(CN3CCN(CCO)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc(C(N)=O)n1C CHEMBL1236871 IC50 3.6 nM
Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc(C(N)=O)n1C CHEMBL1784634 IC50 3.6 nM
CCNC(=O)Nc1nc2ccc(-c3ccccc3OC(F)(F)F)cc2s1 CHEMBL2347712 IC50 3.6 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)c1ccc(OCCN2CCOCC2)c(-c2cncnc2)c1 CHEMBL3950645 IC50 3.6 nM
CO[C@H]1CN(c2ncc(C(=O)Nc3ccc(OC(F)(F)F)cc3)cc2-c2ccn[nH]2)C[C@@H]1N CHEMBL3916467 IC50 3.6 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(N2C[C@H](O)[C@@H](F)C2)c(-c2ccn[nH]2)c1 CHEMBL3908439 IC50 3.7 nM
Cc1ccccc1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)sc2c1 CHEMBL4867416 IC50 3.71 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(N2CCOC(CO)C2)c(-c2cncnc2)c1 CHEMBL3918845 IC50 3.9 nM
N#Cc1cncc(-c2cccc(C(=O)Nc3ccc(OC(F)(F)F)cc3)c2)c1 CHEMBL3944484 IC50 3.9 nM
O=C(Nc1ccc(OC(F)(F)Cl)cc1)c1cnc(Cl)c(-c2cncc(F)c2)c1 CHEMBL3977120 IC50 3.9 nM
CNC(=O)C(C)n1cc(-c2cnc(N)c3c(-c4ccc(NC(=O)Nc5ccc(C)cc5)cc4)csc23)cn1 CHEMBL1970142 pKi 3.981 nM
CN1CCN(C2CCC(n3cc(-c4ccc(Oc5ccccc5)cc4)c4c(N)ncnc43)CC2)CC1 CHEMBL1997617 pKi 3.981 nM
Cc1cc2cc(-c3csc4c(-c5cccc(S(C)(=O)=O)c5)cnc(N)c34)ccc2[nH]1 CHEMBL1997822 pKi 3.981 nM
O=C(Nc1c[nH]nc1-c1nc2ccc(CN3CCOCC3)cc2[nH]1)NC1CC1 CHEMBL495727 IC50 4.0 nM
COc1cc2c(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3F)ccnc2cc1OCCCN1CCOCC1 CHEMBL1230609 Kd 4.0 nM
O=C(Nc1cc2ccc(-c3cncnc3)cc2cn1)C1CC1 CHEMBL3685059 Ki 4.0 nM
O=C(Nc1cc2ccc(OC(F)F)cc2cn1)C1CC1 CHEMBL3685093 Ki 4.0 nM
CCNC(=O)Nc1ncc2cc(-c3cc(F)ccc3C)ccc2c1F CHEMBL3685117 Ki 4.0 nM
Cc1ncc(-c2ccc3cc(NC(=O)C4CC4)ncc3c2)cc1F CHEMBL3685126 Ki 4.0 nM
COc1cccc(Nc2cc3ccc(-c4cc(F)ccc4C)cc3cn2)n1 CHEMBL3685128 Ki 4.0 nM
Cc1ccc(F)cc1-c1ccc2cc(NC(=O)N3CCN(C)CC3)ncc2c1 CHEMBL3685129 Ki 4.0 nM
Nc1cncc(-c2ccc3cc(NC(=O)C4CC4)ncc3c2)c1 CHEMBL3685143 Ki 4.0 nM
Cc1ccccc1-c1ccc2cnc(NC(=O)C3CC3)cc2c1 CHEMBL3685197 Ki 4.0 nM
Cc1ncc(N)cc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3689566 Ki 4.0 nM
CO[C@H](C)C(=O)Nc1ccc(C)c(-c2ccc3cc(NC(=O)C4CC4)ncc3c2)c1 CHEMBL3689586 Ki 4.0 nM
Cc1cnc(CO)cc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3639884 Ki 4.0 nM
Cc1ccc(F)cc1-c1cc2cnc(NC(=O)C3CC3)cc2c(OC2CCCC2)n1 CHEMBL3689652 Ki 4.0 nM
COc1ccc(-c2cc(C(=O)Nc3ccc(OC(F)(F)F)cc3)cnc2N2CC[C@@H](O)C2)cn1 CHEMBL4111391 IC50 4.0 nM
CC(C)(O)c1cc(F)cc(-c2cc(C(=O)Nc3ccc(OC(F)(F)F)cc3)cnc2N2CC[C@@H](O)C2)c1 CHEMBL4108461 IC50 4.0 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(N2CC[C@@H](O)C2)c(-c2ccc3ccncc3c2)c1 CHEMBL4113400 IC50 4.0 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(N2CC[C@H](CO)C2)c(-c2ccc(Cl)nc2)c1 CHEMBL3894811 IC50 4.0 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(N2CCCC(O)C2)c(-c2cccnc2)c1 CHEMBL3977958 IC50 4.0 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(N2CCCNCC2)c(-c2cccnc2)c1 CHEMBL3965771 IC50 4.0 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(N2C3COCC2COC3)c(-c2cncnc2)c1 CHEMBL3919206 IC50 4.0 nM
Cc1ccc(C(=O)Nc2ccc(OC(F)(F)F)cc2)cc1-c1cccnc1 CHEMBL3962532 IC50 4.0 nM
Cc1ccc(C(=O)Nc2ccc(OC(F)(F)F)cc2)cc1-n1ccnc1 CHEMBL3979404 IC50 4.0 nM
CO[C@H]1CN(c2ccc(C(=O)Nc3ccc(OC(F)(F)F)cc3)cc2-c2cncs2)C[C@@H]1O CHEMBL3923589 IC50 4.0 nM
CC1(O)CN(c2ncc(C(=O)Nc3ccc(OC(F)(F)F)cc3)cc2-c2ccn[nH]2)C1 CHEMBL3969546 IC50 4.0 nM
O=C(c1ccc(/C=C/c2n[nH]c3ccccc23)cc1)N1CCNCC1 CHEMBL1908397 IC50 4.0 nM
Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)cc2)cc1C#Cc1cnc2cccnn12 CHEMBL5202391 IC50 4.0 nM
N[C@]1(C(F)(F)F)CCN(c2ncc(C(=O)Nc3ccc(OC(F)(F)F)cc3)cc2-c2ccn[nH]2)C1 CHEMBL4107596 IC50 4.1 nM
Cc1cc(-c2cc(O)ccc2Cl)cc2nnc(Nc3ccc(C(=O)N4CCS(=O)(=O)CC4)cc3)nc12 CHEMBL249819 Ki 4.2 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(OCCNCCO)c(-c2cncnc2)c1 CHEMBL3957513 IC50 4.2 nM
Cc1cnc(-c2cc(C(=O)Nc3ccc(OC(F)(F)F)cc3)cnc2N2CC[C@@H](O)C2)[nH]1 CHEMBL4110085 IC50 4.2 nM
Cc1cc(-c2cc(Cl)ccc2O)cc2nnc(Nc3ccc(C(=O)N4CCS(=O)(=O)CC4)cc3)nc12 CHEMBL5267335 Ki 4.2 nM
Nc1ncnc2c1c(-c1ccc(F)c(O)c1)nn2C1CCCC1 CHEMBL1242568 IC50 4.3 nM
Cc1ccc(C(=O)Nc2ccc(CN3CCN(CC(=O)O)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc(C(N)=O)n1C CHEMBL1784639 IC50 4.3 nM
O=C(Nc1ccc(OC(F)(F)F)c(Cl)c1)c1cnc(N2CC[C@@H](O)C2)c(-c2cncnc2)c1 CHEMBL4113417 IC50 4.3 nM
OC[C@H](Nc1cnc(-c2cc(Cl)ccc2O)c(-c2ccc3cnccc3c2)c1)c1ccccc1 CHEMBL4067871 IC50 4.3 nM
Cc1nc(Nc2ncc(C(=O)Nc3c(Cl)ccnc3C)s2)cc(N2CCN(C)CC2)n1 CHEMBL4851745 IC50 4.3 nM
Cc1cc(-c2cc(O)ccc2Cl)cc2nnc(Nc3ccc(S(=O)(=O)N4CCNCC4)cc3)nc12 CHEMBL250623 Ki 4.4 nM
O=C(Nc1nc2ccc(-c3ccccc3)cc2s1)[C@@H]1C[C@@H]1F CHEMBL4862792 IC50 4.4 nM
Cc1cc(-c2cc(Cl)ccc2O)cc2nnc(Nc3ccc(S(=O)(=O)N4CCNCC4)cc3)nc12 CHEMBL5286481 Ki 4.4 nM
Cc1nc(NCCO)cc(Nc2ncc(C(=O)Nc3c(Cl)ccnc3C)s2)n1 CHEMBL4857318 IC50 4.43 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(N2CC[C@@H](O)C2)c(-c2cc(F)nc(F)c2)c1 CHEMBL4114540 IC50 4.5 nM
O=C(Nc1cn2cc(-c3cccc(F)c3OCCF)ccc2n1)[C@@H]1C[C@@H]1F CHEMBL5437157 IC50 4.69 nM
Cn1c(=O)c(-c2c(Cl)cccc2Cl)cc2cnc(Nc3ccc(NC(=O)CCN)cc3)nc21 CHEMBL566635 IC50 4.7 nM
CC(=O)Nc1ccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)cc1 CHEMBL566850 IC50 4.8 nM
COCCN1CCN(Cc2ccc(NC(=O)c3ccc(C)c(C#Cc4cnc(C(N)=O)n4C)c3)cc2C(F)(F)F)CC1 CHEMBL1784638 IC50 4.8 nM
O=C(Nc1cn2cc(-c3ccccc3CCF)ccc2n1)[C@@H]1C[C@@H]1F CHEMBL5428068 IC50 4.89 nM
Cn1c(=O)c(-c2c(Cl)cccc2Cl)cc2cnc(Nc3cccc(COCC(O)CO)c3)nc21 CHEMBL566834 IC50 4.9 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)c1ccc(Cl)c(-c2cc[nH]n2)c1 CHEMBL3946836 IC50 4.9 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(Cl)c(-c2cncc(F)c2)c1 CHEMBL3901009 IC50 4.9 nM
Cc1cc(-c2c(O)cccc2Cl)cc2nnc(Nc3ccc(S(=O)(=O)NCCN4CCCC4)cc3)nc12 CHEMBL231220 Ki 5.0 nM
CC1(C)CC(NC(=O)c2cccc(-c3cc4nccc(Nc5cccc(O)c5)n4n3)c2)CC(C)(C)N1[O] CHEMBL1163016 IC50 5.0 nM
CC(=O)Nc1cccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)c1 CHEMBL565801 IC50 5.0 nM
CO[C@@H](C(=O)N1Cc2[nH]nc(NC(=O)c3ccc(N4CCN(C)CC4)cc3)c2C1)c1ccccc1 CHEMBL402548 IC50 5.0 nM
O=C(Nc1cc2ccc(Oc3ccccc3Cl)cc2cn1)C1CC1 CHEMBL3685105 Ki 5.0 nM
O=C(Nc1cc2ccc(Oc3cccc(F)c3)cc2cn1)C1CC1 CHEMBL3685106 Ki 5.0 nM
Cc1ccc(F)cc1-c1ccc2cc(NC(=O)OC(C)C)ncc2c1 CHEMBL3685142 Ki 5.0 nM
Cc1cc(CO)cc(Nc2cc3ccc(-c4cc(F)ccc4C)cc3cn2)n1 CHEMBL3685152 Ki 5.0 nM
Cc1cc(C(C)(C)O)cc(Nc2cc3ccc(-c4cc(F)ccc4C)cc3cn2)n1 CHEMBL3685153 Ki 5.0 nM
C[C@H](CNC(=O)c1ccc(CN2CCN(C)CC2)cc1)Cc1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3685192 Ki 5.0 nM
C[C@@H](CNC(=O)c1ccc(CN2CCN(C)CC2)cc1)Cc1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3685193 Ki 5.0 nM
O=C(Nc1cc2ccc(OC3COC[C@@H]3O)cc2cn1)C1CC1 CHEMBL3689556 Ki 5.0 nM
O=C(Nc1cc2ccc(OC3COC[C@H]3O)cc2cn1)C1CC1 CHEMBL3689557 Ki 5.0 nM
Cc1ccncc1-c1ccc2c(C#N)c(N)ncc2c1 CHEMBL3689619 Ki 5.0 nM
O=C(Nc1cc2c(=O)[nH]c(-c3ccccc3Cl)cc2cn1)C1CC1 CHEMBL3689639 Ki 5.0 nM
Cc1ccc(F)cc1-c1cc2cnc(NC(=O)C3CC3)cc2c(NC2CCCC2)n1 CHEMBL3689657 Ki 5.0 nM
CNCc1nc(-c2cc(F)ccc2C)cc2cnc(NC(=O)C3CC3)cc12 CHEMBL3689674 Ki 5.0 nM
Cc1ccc2[nH]ncc2c1-c1ccc2cc(NC(=O)[C@@H]3C[C@@H]3F)ncc2c1 CHEMBL3689748 Ki 5.0 nM
Cc1ncccc1-c1cc(C(=O)Nc2ccc(OC(F)(F)F)cc2)cnc1N1CC[C@@H](O)C1 CHEMBL4113564 IC50 5.0 nM
N#Cc1ncc(-c2cc(C(=O)Nc3ccc(OC(F)(F)F)cc3)cnc2N2CC[C@H](CO)C2)cn1 CHEMBL3907859 IC50 5.0 nM
N#Cc1ccc(-c2cc(C(=O)Nc3ccc(OC(F)(F)F)cc3)cnc2N2CC[C@H](CO)C2)cn1 CHEMBL3909640 IC50 5.0 nM
Cc1ccc(-c2cc(C(=O)Nc3ccc(OC(F)(F)F)cc3)cnc2N2CC[C@@H](CN)C2)cn1 CHEMBL3977260 IC50 5.0 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(N2CCC[C@@H](O)C2)c(-c2cccnc2)c1 CHEMBL4113562 IC50 5.0 nM
Cc1ccc(-c2cc(C(=O)Nc3ccc(OC(F)(F)F)cc3)cnc2N2CC(C(C)(C)O)C2)cn1 CHEMBL3918681 IC50 5.0 nM
CN(CCO)c1ncc(C(=O)Nc2ccc(OC(F)(F)F)cc2)cc1-c1cncc(C#N)c1 CHEMBL3891720 IC50 5.0 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(Cl)c(-c2ncc[nH]2)c1 CHEMBL3930248 IC50 5.0 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(N2CCOCC2)c(-c2ccn[nH]2)c1 CHEMBL3899632 IC50 5.0 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(N2CCOC(CO)C2)c(-c2ccn[nH]2)c1 CHEMBL3982715 IC50 5.0 nM
CN(CCO)c1ccc(C(=O)Nc2ccc(OC(F)(F)F)cc2)cc1-c1cncs1 CHEMBL3890658 IC50 5.0 nM
CC(C)c1cc(CNc2nc(Nc3cc(C4CC4)[nH]n3)cc(N3CCN(C)CC3)n2)on1 CHEMBL3545085 IC50 5.0 nM
Cc1ccc(C(=O)Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc1Nc1nccc(-c2cccnc2)n1 CHEMBL5208448 IC50 5.0 nM
CCc1cc(Nc2cc3ccc(-c4c(Cl)cccc4Cl)cc3cn2)nc(N2CCOCC2)n1 CHEMBL3689711 Ki 5.02 nM
Cc1nc(Nc2ncc(C(=O)Nc3c(C)csc3Cl)s2)cc(N2CCN(CCO)CC2)n1 CHEMBL4867844 IC50 5.02 nM
Cc1ccncc1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)sc2c1 CHEMBL4868998 IC50 5.07 nM
Cc1ccc(C(=O)Nc2ccc(CN3CC[C@H](N(C)C)C3)c(C(F)(F)F)c2)cc1-n1cc(-c2cnc3[nH]ncc3c2)nn1 CHEMBL2177648 IC50 5.09 nM
Cc1ccc(NC(=O)c2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1Nc1nccc(-c2cccnc2)n1 CHEMBL203343 IC50 5.1 nM
Cc1cc(-c2cc(O)ccc2Cl)cc2nnc(Nc3ccc(S(=O)(=O)N(C)CCN4CCOCC4)cc3)nc12 CHEMBL250423 Ki 5.1 nM
NC1CN(c2ncc(C(=O)Nc3ccc(OC(F)(F)Cl)cc3)cc2-c2cncnc2)C1 CHEMBL3917548 IC50 5.1 nM
O=C(Nc1ccc(OC(F)(F)Cl)cc1)c1cnc(NC[C@H](O)CCO)c(-c2ccn[nH]2)c1 CHEMBL4115349 IC50 5.1 nM
Cc1cc(-c2cc(Cl)ccc2O)cc2nnc(Nc3ccc(S(=O)(=O)N(C)CCN4CCOCC4)cc3)nc12 CHEMBL5275366 Ki 5.1 nM
Cn1c(=O)c(-c2c(Cl)cccc2Cl)cc2cnc(Nc3ccc(O)cc3)nc21 CHEMBL323405 IC50 5.3 nM
Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C3CC3)c2)cc1C#Cc1cnc2cccnn12 CHEMBL1172719 IC50 5.3 nM
COC(=O)c1cc2cc(NCc3c(Cl)cccc3Cl)cnc2[nH]1 CHEMBL3347468 IC50 5.3 nM
CN(C)C1CN(c2ncc(C(=O)Nc3ccc(OC(F)(F)F)cc3)cc2-c2cncnc2)C1 CHEMBL3927318 IC50 5.3 nM
O=C(Nc1ccc(OC(F)(F)Cl)cc1)c1cnc(NCCC(O)C(=O)O)c(-c2ccn[nH]2)c1 CHEMBL3902696 IC50 5.3 nM
COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 CHEMBL509032 Kd 5.4 nM
Cc1ccc(NC(=O)c2ccc3c(c2)CCC3N2CCN(C(C)C)CC2)cc1Nc1nccc(-c2cccnc2)n1 CHEMBL3690076 IC50 5.4 nM
CN(CCO)c1ncc(C(=O)Nc2ccc(OC(F)(F)F)cc2)cc1-c1cccnc1 CHEMBL3968302 IC50 5.4 nM
Cc1ncc(-c2cc(C(=O)Nc3ccc(OC(F)(F)F)cc3)cnc2N2CC(C)(O)C2)cn1 CHEMBL3986284 IC50 5.4 nM
CC(C)n1nc(-c2ccc(Cl)c(O)c2)c2c(N)ncnc21 CHEMBL1241484 IC50 5.5 nM
O=C(Nc1ccc(OC(F)(F)Cl)cc1)c1cnc(N2CCC(F)(F)C2)c(-c2ccn[nH]2)c1 CHEMBL3929135 IC50 5.5 nM
Cc1cnccc1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)sc2c1 CHEMBL4868871 IC50 5.56 nM
CCNC(=O)Nc1nc2ccc(-c3ccc(OC)cc3)cc2s1 CHEMBL2347718 IC50 5.6 nM
COc1ncc(-c2cc(C(=O)Nc3ccc(OC(F)(F)F)cc3)ccc2N2CC[C@@H](O)C2)cn1 CHEMBL4109149 IC50 5.6 nM
O=C(Nc1cc2ccc(-c3ccncc3)cc2cn1)C1CC1 CHEMBL3689703 Ki 5.65 nM
O=C(Nc1ccc(OC(F)(F)Cl)cc1)c1cnc(NCC(O)CCO)c(-c2ccn[nH]2)c1 CHEMBL3941562 IC50 5.7 nM
O=C(Nc1ccc(OC(F)(F)Cl)cc1)c1cnc(NC[C@@H](O)CCO)c(-c2ccn[nH]2)c1 CHEMBL3893732 IC50 5.7 nM
Cc1ccc(NC(=O)c2ccc3c(c2)CCC3N2CCN(C)CC2)cc1Nc1nccc(-c2cccnc2)n1 CHEMBL3690072 IC50 5.8 nM
CCn1cc(-c2ccc3c(c2)ncn3-c2cc(OC)c(C(N)=O)c(OC)c2)cn1 CHEMBL5438171 IC50 5.9 nM
CCCP(=O)(CCC)c1ccc(Nc2nc(C(C)C)nc3c2ncn3/C=C/c2c(C)cccc2C)cc1 CHEMBL528330 IC50 5.93 nM
Fc1ccc(CNc2ncnc3c2cnn3CC(Cl)c2ccc(Br)cc2)cc1 CHEMBL2397809 Ki 6.0 nM
COC(=O)c1cc2cc(NCc3cc(NC(=O)c4cc(-n5cnc(C)c5)cc(C(F)(F)F)c4)ccc3C)cnc2[nH]1 CHEMBL3808884 IC50 6.0 nM
Cc1cncc(C(=O)N2CCC(Oc3cc(NC(=O)c4ccc(CN5CCN(C)CC5)c(C(F)(F)F)c4)ccc3C)CC2)c1 CHEMBL3957831 IC50 6.0 nM
O=C(Nc1cc2ccc(N3CCCCC3)cc2cn1)C1CC1 CHEMBL3684995 Ki 6.0 nM
O=C(Nc1cc2ccc(Oc3cccnc3)cc2cn1)C1CC1 CHEMBL3685109 Ki 6.0 nM
O=C(Nc1cc2ccc(OCCO)cc2cn1)C1CC1 CHEMBL3685165 Ki 6.0 nM
O=C(Nc1cc2c(O)cc(-c3ccccc3Cl)nc2cn1)C1CC1 CHEMBL3689689 Ki 6.0 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(N2CC[C@@H](O)C2)c(-c2cccc(CO)c2)c1 CHEMBL4108992 IC50 6.0 nM
CC(C)(O)C1CCN(c2ncc(C(=O)Nc3ccc(OC(F)(F)F)cc3)cc2-c2cccnc2)C1 CHEMBL3962815 IC50 6.0 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(N2CC(CO)C2)c(-c2cnc(Cl)c(F)c2)c1 CHEMBL3906333 IC50 6.0 nM
CC(C)(O)C1CN(c2ncc(C(=O)Nc3ccc(OC(F)(F)F)cc3)cc2-c2cncnc2)C1 CHEMBL3903302 IC50 6.0 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(C2=CCOCC2)c(-c2cncnc2)c1 CHEMBL3987130 IC50 6.0 nM
Cc1n[nH]c2ccc(-c3cc(N[C@@H](CO)c4ccccc4)cnc3-c3ccc(F)cc3O)cc12 CHEMBL4075917 IC50 6.1 nM
CCNC(=O)Nc1nc2ccc(-c3ccccc3OC)cc2o1 CHEMBL2347709 IC50 6.12 nM
COc1ccncc1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)sc2c1 CHEMBL4850262 IC50 6.13 nM
CCNC(=O)Nc1nc2ccc(-c3ccccc3OC)cc2[nH]1 CHEMBL2347739 IC50 6.2 nM
Cc1ccc(NC(=O)c2ccc3c(c2)CCC3N2CCNCC2)cc1Nc1nccc(-c2cccnc2)n1 CHEMBL3690074 IC50 6.2 nM
N#CC1(c2ncc(C(=O)Nc3ccc(OC(F)(F)F)cc3)cc2-c2cncnc2)CCC1 CHEMBL4110559 IC50 6.2 nM
CCN1CCN(C2CCc3cc(C(=O)Nc4ccc(C)c(Nc5nccc(-c6cccnc6)n5)c4)ccc32)CC1 CHEMBL3690075 IC50 6.3 nM
CC(=O)Nc1cccn2c(C#Cc3cc(C(=O)Nc4cc(-n5ccnc5)cc(C(F)(F)F)c4)ccc3C)cnc12 CHEMBL1172585 IC50 6.4 nM
CC1CCC(n2nc(-c3ccc(F)c(O)c3)c3c(N)ncnc32)C1 CHEMBL1242656 IC50 6.4 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(N2CC[C@@H](O)C2)c(-c2ncc[nH]2)c1 CHEMBL4109885 IC50 6.4 nM
Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cn(C)c(-c2ncc(C(F)(F)F)[nH]2)n1 CHEMBL3935947 IC50 6.45 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)c1cccc(-c2cnc(OCCO)nc2)c1 CHEMBL3973934 IC50 6.5 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(N2CC[C@@H](O)C2)c(-c2ccccc2)c1 CHEMBL4114324 IC50 6.6 nM
N#CC1(c2ncc(C(=O)Nc3ccc(OC(F)(F)F)cc3)cc2-c2cncnc2)CCOCC1 CHEMBL3943529 IC50 6.6 nM
O=C(Nc1ccc(OC(F)(F)Cl)cc1)c1cnc(NCCC(O)CO)c(-c2ccn[nH]2)c1 CHEMBL3986023 IC50 6.6 nM
Cc1n[nH]c2ccc(-c3cc(N[C@@H](CO)c4ccccc4)cnc3-c3cc(Cl)ccc3O)cc12 CHEMBL4105329 IC50 6.6 nM
Cc1cccc(C)c1/C=C/n1cnc2c(Nc3ccc(P(C)(C)=O)cc3)nc(N3CCN(C)CC3)nc21 CHEMBL509941 IC50 6.8 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)c1cncc(-c2cncnc2)c1 CHEMBL3913939 IC50 6.8 nM
Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1ccc(-c2ncc[nH]2)nc1 CHEMBL3919620 IC50 6.81 nM
Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2[nH]c(=O)[nH]c2c1 CHEMBL1171658 IC50 6.9 nM
CN(CCO)c1ncc(C(=O)Nc2ccc(OC(F)(F)F)cc2)cc1-c1ccn[nH]1 CHEMBL3901311 IC50 6.9 nM
c1ccc(CN2CCC(Nc3ccc4[nH]nc(-c5nc6cc(N7CCC(N8CCCCC8)CC7)ccc6[nH]5)c4c3)CC2)cc1 CHEMBL209753 IC50 7.0 nM
CC(C)(C)n1nc(-c2cccc3ccccc23)c2c(N)ncnc21 CHEMBL264406 IC50 7.0 nM
Cc1ccc(NC(=O)c2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1OC1CCN(C(=O)c2ccncc2)CC1 CHEMBL3894450 IC50 7.0 nM
Clc1ccccc1-c1ccc2cc(Nc3ccccn3)ncc2c1 CHEMBL3684997 Ki 7.0 nM
Cc1ccc(F)cc1-c1ccc2cc(NC(=O)c3ccncc3)ncc2c1 CHEMBL3685032 Ki 7.0 nM
Cn1ccc(Oc2ccc3cc(NC(=O)C4CC4)ncc3c2)n1 CHEMBL3685132 Ki 7.0 nM
Nc1cc(-c2ccc3cc(NC(=O)C4CC4)ncc3c2)ccn1 CHEMBL3685144 Ki 7.0 nM
Cc1ccc(F)cc1-c1ccc2cc(NC(=O)C3CC3c3ccccc3)ncc2c1 CHEMBL3685151 Ki 7.0 nM
CCOc1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3685164 Ki 7.0 nM
Cc1ccc(NC(=O)C2CCN(C)CC2)cc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3685176 Ki 7.0 nM
O=C(Nc1cc2ccc(OC3CCC3)cc2cn1)C1CC1 CHEMBL3685190 Ki 7.0 nM
Cc1cc(C(C)(C)O)ccc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3689627 Ki 7.0 nM
O=C(Nc1cc2ccc(C3(O)CCCC3)nc2cn1)C1CC1 CHEMBL3689690 Ki 7.0 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(N2CCC(O)C2)c(-c2ccncc2)c1 CHEMBL3960404 IC50 7.0 nM
Cc1ccc(-c2cc(C(=O)Nc3ccc(OC(F)(F)F)cc3)cnc2N2CC[C@H](N)C2)cn1 CHEMBL3902824 IC50 7.0 nM
O=C(Nc1ccc(OC(F)(F)C(F)F)cc1)c1cnc(N2CC[C@@H](O)C2)c(-c2cncc(F)c2)c1 CHEMBL4113196 IC50 7.0 nM
Cc1ccc(-c2cc(C(=O)Nc3ccc(OC(F)(F)C(F)F)cc3)cnc2N2CC[C@@H](O)C2)cn1 CHEMBL4108599 IC50 7.0 nM
Nc1cnc(-c2cccc(C(=O)Nc3ccc(OC(F)(F)F)cc3)c2)cn1 CHEMBL3903055 IC50 7.0 nM
Cc1cc(-c2cc(C(=O)Nc3ccc(OC(F)(F)F)cc3)cnc2N2CC(O)C2)[nH]n1 CHEMBL3936417 IC50 7.0 nM
CN1CCN(c2ncc(C(=O)Nc3ccc(OC(F)(F)F)cc3)cc2-c2cncnc2)CC1 CHEMBL3910823 IC50 7.0 nM
CC(C)n1nc(C#Cc2cccc3cc(-c4ccc(CN5CCN(C)CC5)cc4)ncc23)c2c(N)ncnc21 CHEMBL4237900 IC50 7.0 nM
Cc1ccc(C(=O)Nc2ccc(Cl)cc2Cl)cc1C#Cc1cc(-c2cnn(C)c2)cnc1N CHEMBL4467948 IC50 7.0 nM
N#Cc1cc(-c2cc(C(=O)Nc3ccc(OC(F)(F)F)cc3)cnc2N2CCCC2)[nH]n1 CHEMBL3963812 IC50 7.1 nM
Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1Nc1cc(-c2cccnc2)ccn1 CHEMBL5218915 IC50 7.1 nM
CN(CCO/N=C1C(=C2/C(=O)Nc3cc(Br)ccc32)/Nc2ccccc2/1)CC(O)CO CHEMBL494867 IC50 7.2 nM
Cc1cccc(C)c1/C=C/n1cnc2c(Nc3ccc(P(C)(C)=O)cc3)nc(OC(C)C)nc21 CHEMBL516498 IC50 7.32 nM
Cc1ncccc1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)sc2c1 CHEMBL4851470 IC50 7.48 nM
Cn1c(=O)c(-c2c(Cl)cccc2Cl)cc2cnc(Nc3ccc(NC(=O)CCl)cc3)nc21 CHEMBL565587 IC50 7.6 nM
Cc1ccsc1-c1ccc2nc(NC(=O)[C@@H]3C[C@@H]3F)sc2c1 CHEMBL4879160 IC50 7.6 nM
Cc1cc(-c2cc(O)ccc2Cl)cc2nnc(Nc3ccc(S(N)(=O)=O)cc3)nc12 CHEMBL249820 Ki 7.7 nM
Cc1ccc(C(=O)NC2(C)CCC2)cc1-c1ccc2cc(N)ncc2c1 CHEMBL3689750 Ki 7.7 nM
Cc1cc(-c2cc(Cl)ccc2O)cc2nnc(Nc3ccc(S(N)(=O)=O)cc3)nc12 CHEMBL5285787 Ki 7.7 nM
O=C(Nc1ccc(OC(F)(F)Cl)cc1)c1cnc(NCC[C@H](O)CO)c(-c2ccn[nH]2)c1 CHEMBL3918260 IC50 7.8 nM
CN1CCN(Cc2ccc(C(=O)Nc3ccc(CC(=O)Nc4ccc(NC(=O)C5CC5)nc4)cc3)cc2C(F)(F)F)CC1 CHEMBL5188231 IC50 7.9 nM
Cc1ncn(-c2cc(NC(=O)c3ccc(C)c(-n4cc(-c5cnc6[nH]ncc6c5)nn4)c3)cc(C(F)(F)F)c2)n1 CHEMBL2178274 IC50 7.93 nM
CCN(CC)CCCNC(=O)c1cnc(N)c2c(-c3ccc(NC(=O)Nc4cccc(C)c4)cc3)csc12 CHEMBL1999414 pKi 7.943 nM
CCN(CC)CCCNC(=O)c1cnc(N)c2c(-c3ccc(NC(=O)Nc4cccc(F)c4)cc3)csc12 CHEMBL1996649 pKi 7.943 nM
CNS(=O)(=O)c1ccccc1Nc1nc(Nc2cc(OC)c(OC)c(OC)c2)ncc1Cl CHEMBL1993661 pKi 7.943 nM
Cn1c(=O)c(-c2c(Cl)cccc2Cl)cc2cnc(NCc3cccc(N)c3)nc21 CHEMBL1223343 Ki 8.0 nM
CC(C)n1nc(C#Cc2cccc(O)c2)c2c(N)ncnc21 CHEMBL1213120 IC50 8.0 nM
O=C(Nc1cc2ccc(Oc3cccc(Cl)c3)cc2cn1)C1CC1 CHEMBL3685107 Ki 8.0 nM
COC[C@H](C)Oc1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3685168 Ki 8.0 nM
Cc1ccc(F)cc1-c1cc(O)c2cc(NC(=O)C3CC3)ncc2n1 CHEMBL3689687 Ki 8.0 nM
O=C(Nc1ccc(S(=O)(=O)C(F)(F)F)cc1)c1cnc(N2CC[C@@H](O)C2)c(-c2cncnc2)c1 CHEMBL4106446 IC50 8.0 nM
COc1ncc(-c2cc(C(=O)Nc3ccc(OC(F)(F)F)cc3)ccc2Cl)cn1 CHEMBL3912888 IC50 8.1 nM
Cn1c(=O)c(-c2c(Cl)cccc2Cl)cc2cnc(Nc3ccc(CCO)cc3)nc21 CHEMBL576218 IC50 8.2 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(N2CCNC3(CC3)C2)c(-c2ccn[nH]2)c1 CHEMBL3945312 IC50 8.3 nM
COc1ccc(C(=O)Nc2ccc(OC(F)(F)F)cc2)cc1-c1ccncc1 CHEMBL3952623 IC50 8.7 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)c1cncc(-c2cccnc2)c1 CHEMBL3889746 IC50 8.7 nM
O=C(Nc1nc2ccc(-c3cnccc3Cl)cc2s1)[C@@H]1C[C@@H]1F CHEMBL4851636 IC50 8.74 nM
Cc1ccc(NC(=O)c2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1Nc1nccc(-c2cncnc2)n1 CHEMBL205723 IC50 8.8 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(OC2CCOCC2)c(-c2cncnc2)c1 CHEMBL3921051 IC50 8.9 nM
Cc1ccc(NC(=O)c2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2ccccn12 CHEMBL1171281 IC50 9.0 nM
COc1cc2/c(=N/c3ccc(Br)cc3F)nc[nH]c2cc1OCC1CCN(C)CC1 CHEMBL24828 Kd 9.0 nM
CC(C)(C)c1cc(NC(=O)Nc2cccc(Nc3ncnc4ccccc34)c2)n(-c2cccc([N+](=O)[O-])c2)n1 CHEMBL2403874 IC50 9.0 nM
Cc1ccc(F)cc1-c1ccc2cc(NC(=O)C(C)C)ncc2c1 CHEMBL3685058 Ki 9.0 nM
Cn1ncc2c(-c3ccc4cc(NC(=O)C5CC5)ncc4c3)cccc21 CHEMBL3685149 Ki 9.0 nM
O=C(Nc1cc2ccc(OC3CCCC[C@H]3O)cc2cn1)C1CC1 CHEMBL3689570 Ki 9.0 nM
O=C(Nc1cc2ccc(OC3CCCC[C@@H]3O)cc2cn1)C1CC1 CHEMBL3689571 Ki 9.0 nM
Cc1ncc(NC(=O)C2CCOCC2)cc1-c1ccc2cc(NC(=O)C3CC3)ncc2c1 CHEMBL3689572 Ki 9.0 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(N2CC[C@@H](O)C2)c(-c2cnoc2)c1 CHEMBL4108473 IC50 9.0 nM
NC(=O)c1cccc(-c2cc(Nc3ccc(OC(F)(F)F)cc3)ncn2)c1 CHEMBL483847 IC50 9.0 nM
Cc1ccncc1-c1ccc2nc(NC(=O)C3CC3)sc2c1 CHEMBL4869280 IC50 9.03 nM
Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCF)CC2)n1 CHEMBL240158 IC50 9.1 nM
Cc1ccc(C(=O)Nc2ccc(OC3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2ccccn12 CHEMBL1169881 IC50 9.1 nM
Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1Nc1nccc(-c2cccnc2)n1 CHEMBL5207077 IC50 9.1 nM
CC(C)(O)c1ncc(C(=O)Nc2ccc(OC(F)(F)F)cc2)cc1-c1cncnc1 CHEMBL3951132 IC50 9.3 nM
Cc1cn(-c2cc(F)cc(NC(=O)c3ccc(C)c(Nc4nccc(-c5cccnc5)n4)c3)c2)cn1 CHEMBL2311807 Kd 9.4 nM
CCOc1ncc(C(=O)Nc2ccc(OC(F)(F)F)cc2)cc1-c1cncnc1 CHEMBL3926819 IC50 9.4 nM
CCc1ccc(C(=O)Nc2cc(CN3CCN(C)CC3)cc(C(F)(F)F)c2)cc1C#Cc1cnc2cnccn12 CHEMBL4175086 IC50 9.4 nM
COc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12 CHEMBL5171402 IC50 9.4 nM
O=C(Nc1ccc(OC(F)(F)Cl)cc1)c1cccc(-c2cncnc2)c1 CHEMBL3953864 IC50 9.5 nM
Cc1ccncc1-c1ccc2nc(NC(=O)[C@H]3C[C@@H]3F)sc2c1 CHEMBL4874824 IC50 9.65 nM
Cn1cc(/C=C2\Oc3cccc(O)c3C2=O)c2c(-c3ccc(C(=O)NCCO)cc3)ccnc21 CHEMBL1092754 IC50 9.7 nM
CN1CCN(Cc2ccc(NC(=O)c3ccc(F)c(-n4cc(-c5cnc6[nH]ncc6c5)nn4)c3)cc2C(F)(F)F)CC1 CHEMBL2178276 IC50 9.83 nM
COc1ccc(C(=O)Nc2ccc(OC(F)(F)F)cc2)cc1-c1ccc2c(c1)OCO2 CHEMBL3944685 IC50 9.9 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)c1cnc(Cl)c(-c2cncnc2)c1 CHEMBL3932245 IC50 9.9 nM