COc1ccc(F)cc1[C@H](Cn1c(=O)n(C(C)(C)C(=O)NS(=O)(=O)C2(C)CC2)c(=O)c2c(C)c(-n3nccn3)sc21)O[C@@H]1C[C@H]2CC[C@@H](C1)O2 CHEMBL4875701 EC50 0.3 nM
C[C@@H](COc1cnc(-c2ccc(Oc3cccc(OCC4CC4)c3)cc2)o1)NC(N)=O CHEMBL4073202 IC50 0.58 nM
CC(=O)NC(C)c1ccc2nc(-c3ccc(Oc4cccc(OCC5CC5)c4)nc3)oc2c1 CHEMBL4060253 IC50 0.76 nM
Cc1c(-n2nccn2)sc2c1c(=O)n(C1(C(=O)NS(=O)(=O)C3(C)CC3)CC1)c(=O)n2C[C@H](O[C@@H]1C[C@H]2CC[C@@H](C1)O2)c1cc(F)ccc1OC(F)F CHEMBL4874989 EC50 0.9 nM
CN(C)c1cc(C(=O)N2CCC3(CC2)CC(=O)c2nc(C(C)(C)C)sc2C3)cc(-c2ccc(C(N)=O)cc2)n1 CHEMBL5404551 IC50 0.9 nM
CC(=O)N[C@@H](C)COc1cnc(-c2ccc(Oc3cccc(OCC4CC4)c3)cc2)o1 CHEMBL4085633 IC50 0.96 nM
CC(=O)N[C@@H](C)COc1cnc(-c2ccc(Oc3cccc(OCC4CC4)c3)nc2)o1 CHEMBL4086127 IC50 0.96 nM
COc1ccccc1[C@H](Cn1c(=O)n(C(C)(C)C(=O)NS(=O)(=O)C2(C)CC2)c(=O)c2c(C)c(-n3nccn3)sc21)O[C@@H]1C[C@H]2CC[C@@H](C1)O2 CHEMBL4864719 EC50 1.0 nM
COc1ccccc1[C@H](Cn1c(=O)n([C@H](C)C(=O)NS(=O)(=O)C2(C)CC2)c(=O)c2c(C)c(-c3ncco3)sc21)O[C@@H]1C[C@H]2CC[C@@H](C1)O2 CHEMBL4875627 EC50 1.0 nM
COc1ccccc1[C@H](Cn1c(=O)n(C(C)(C)C(=O)NS(=O)(=O)C2(C)CC2)c(=O)c2c(C)c(-c3ncco3)sc21)O[C@@H]1C[C@H]2CC[C@@H](C1)O2 CHEMBL4859704 EC50 1.0 nM
COc1ccccc1[C@H](Cn1c(=O)n(C2(C(=O)NS(=O)(=O)C3(C)CC3)CC2)c(=O)c2c(C)c(-n3nccn3)sc21)O[C@@H]1C[C@H]2CC[C@@H](C1)O2 CHEMBL4861716 EC50 1.0 nM
CC(C)(C)n1cc2c(n1)C(=O)CC1(CCN(C(=O)c3cc(-c4ccc(N)cc4)nc4ccccc34)CC1)O2 CHEMBL4777068 IC50 1.29 nM
Cc1cc(C(=O)N2CCC3(CC2)CC(=O)c2nc(C(C)(C)C)sc2C3)c2[nH]ncc2c1Cl CHEMBL5435853 IC50 1.3 nM
COc1cc(C(=O)N2CCC3(CC2)CC(=O)c2nc(C(C)(C)C)sc2C3)c2[nH]ccc2c1Cl CHEMBL5411569 IC50 1.3 nM
CC(NC(N)=O)c1ccc2nc(-c3ccc(Oc4cccc(OCC5CC5)c4)nc3)oc2c1 CHEMBL4528475 IC50 1.5 nM
CNc1ccc2c(OC)cc(C(=O)N3CCC4(CC3)CC(=O)c3nc(C(C)(C)C)sc3C4)cc2n1 CHEMBL5411576 IC50 1.5 nM
COc1ccccc1[C@H](Cn1c(=O)n(C(C)(C)C(=O)O)c(=O)c2c(C)c(-c3ncco3)sc21)OC1CCOCC1 CHEMBL3407547 IC50 1.7 nM
CCCNc1ccc2ccc(C(=O)N3CCC4(CC3)Cc3cn(C(C)(C)C)nc3C(=O)N4)cc2n1 CHEMBL2419600 IC50 1.8 nM
CNc1nc2c(C)cccc2cc1C(=O)N1CCC2(CC1)CC(=O)c1nc(C(C)(C)C)sc1C2 CHEMBL5401918 IC50 1.8 nM
CC(NC(=O)N(C)C)c1ccc2nc(-c3ccc(Oc4cccc(OCC5CC5)c4)nc3)oc2c1 CHEMBL4435891 IC50 2.1 nM
CNc1ccc2ccc(C(=O)N3CCC4(CC3)CC(=O)c3nn(C(C)(C)C)cc3C4)cc2n1 CHEMBL2323626 IC50 2.2 nM
CC(=O)NC(C)c1ccc2nc(-c3ccc(Oc4cccc(OCC5CC5)c4)cc3)oc2c1 CHEMBL4098647 IC50 2.2 nM
CCOc1cc(C(=O)N2CCC3(CC2)CC(=O)c2nc(C(C)(C)C)sc2C3)cc2c(C)nn(C)c12 CHEMBL5436442 IC50 2.2 nM
Cc1ccc(-c2cc(C(=O)N3CCC4(CC3)CC(=O)c3nn(C(C)(C)C)cc3O4)c3ccccc3n2)cc1 CHEMBL4792495 IC50 2.22 nM
CN(C)c1ccc(-c2cc(C(=O)N3CCC4(CC3)CC(=O)c3nn(C(C)(C)C)cc3O4)c3ccccc3n2)cc1 CHEMBL4777090 IC50 2.72 nM
COc1cc(C(=O)N2CCC3(CC2)CC(=O)c2cc(-c4cncc(C(=O)O)c4)ccc2O3)cc2c1c(C)cn2C1CC1 CHEMBL4557289 IC50 3.0 nM
COc1ccc(-c2cc(C(=O)N3CCC4(CC3)CC(=O)c3nn(C(C)(C)C)cc3O4)c3ccccc3n2)cc1 CHEMBL4793476 IC50 3.18 nM
CC(C)(C)n1cc2c(n1)C(=O)NC1(CCN(C(=O)c3ccc4ccc(NC5CCC5)nc4c3)CC1)C2 CHEMBL3699916 IC50 3.4 nM
COc1ccc(-c2cc(C(=O)N3CCC4(CC3)CC(=O)c3nn(C(C)(C)C)cc3O4)c3ccccc3n2)cc1OC CHEMBL4750081 IC50 3.57 nM
CNC(=O)NC(C)c1ccc2nc(-c3ccc(Oc4cccc(OCC5CC5)c4)nc3)oc2c1 CHEMBL4577890 IC50 3.8 nM
CC(=O)NC(C)CCc1cnc(-c2ccc(Oc3cccc(OCC4CC4)c3)cc2)o1 CHEMBL4090919 IC50 4.9 nM
COc1ccc2ncc(C(=O)N3CCC4(CC3)CC(=O)c3c(cnn3C(C)C)C4)cc2c1 CHEMBL2323628 IC50 5.0 nM
CN(C)c1ccc2ccc(C(=O)N3CCC4(CC3)Cc3cn(C(C)(C)C)nc3C(=O)N4)cc2n1 CHEMBL2419589 IC50 5.0 nM
CNc1ccc2ccc(C(=O)N3CCC4(CC3)Cc3cn(C(C)(C)C)nc3C(=O)N4)cc2n1 CHEMBL2419598 IC50 5.6 nM
CC(C)(C)n1cc2c(n1)C(=O)CC1(CCN(C(=O)c3cc(-c4ccc(Br)cc4)nc4ccccc34)CC1)O2 CHEMBL4784855 IC50 5.67 nM
COc1cccc2ccc(C(=O)N3CCC4(CC3)Cc3cn(C(C)(C)C)nc3C(=O)N4)cc12 CHEMBL3699893 IC50 5.8 nM
CC(=O)N[C@@H](C)COc1cnc(-c2ccc(Oc3cccc(OCC4CC4)c3)cn2)o1 CHEMBL4064621 IC50 5.8 nM
CC(C)(C)n1cc2c(n1)C(=O)CC1(CCN(C(=O)c3cc(-c4ccccc4)nc4ccccc34)CC1)O2 CHEMBL4795824 IC50 6.0 nM
CC(C)(C)n1cc2c(n1)C(=O)CC1(CCN(C(=O)c3cc(-c4ccc(Cl)cc4)nc4ccccc34)CC1)O2 CHEMBL4746597 IC50 6.09 nM
CC(C)Nc1ccc2ccc(C(=O)N3CCC4(CC3)Cc3cn(C(C)(C)C)nc3C(=O)N4)cc2n1 CHEMBL3699914 IC50 6.1 nM
CC(C)(C)n1cc2c(n1)C(=O)NC1(CCN(C(=O)c3ccc4ccc(NCC(F)(F)F)nc4c3)CC1)C2 CHEMBL3699929 IC50 6.5 nM
CC1=CC(C(=O)N2CCC3(CC2)Cc2cn(C(C)(C)C)nc2C(=O)N3)=CC2C(C)=NNC12 CHEMBL3699871 IC50 6.6 nM
CC(C)(C)n1cc2c(n1)C(=O)NC1(CCN(C(=O)c3ccc4c(Cl)c[nH]c4c3)CC1)C2 CHEMBL2419593 IC50 7.0 nM
CC(=O)NC(C)c1ccc2nc(-c3ccc(Oc4cccc(OCC5CC5)c4)cn3)oc2c1 CHEMBL4082153 IC50 7.1 nM
COc1ccc(C)c2[nH]c(C(=O)N3CCC4(CC3)Cc3cn(C(C)(C)C)nc3C(=O)N4)cc12 CHEMBL3699881 IC50 7.4 nM
CC(=O)NC(C)c1ccc2sc(-c3ccc(Oc4cccc(OCC5CC5)c4)nc3)nc2c1 CHEMBL4101119 IC50 7.4 nM
CC(C)(C)n1cc2c(n1)C(=O)NC1(CCN(C(=O)c3ccc4ccc(NC5CC5)nc4c3)CC1)C2 CHEMBL3699913 IC50 7.5 nM
CC(C)n1ncc2c1C(=O)CC1(CCN(C(=O)c3cc(-c4ccc(C(=O)O)cc4)nc(N(C)C)c3)CC1)C2 CHEMBL4753907 IC50 7.7 nM
Cc1cc(C(=O)N2CCC3(CC2)Cc2cn(C(C)(C)C)nc2C(=O)N3)cc2c(Cl)n[nH]c12 CHEMBL3699886 IC50 8.4 nM
COc1ccc2ccc(C(=O)N3CCC4(CC3)Cc3cn(C(C)(C)C)nc3C(=O)N4)cc2c1 CHEMBL3699875 IC50 8.5 nM
CCNc1ccc2ccc(C(=O)N3CCC4(CC3)Cc3cn(C(C)(C)C)nc3C(=O)N4)cc2n1 CHEMBL3699918 IC50 8.9 nM
CC(F)(F)CNc1ccc2ccc(C(=O)N3CCC4(CC3)Cc3cn(C(C)(C)C)nc3C(=O)N4)cc2n1 CHEMBL3699930 IC50 9.0 nM
CC(C)(C)n1cc2c(n1)C(=O)CC1(CCN(C(=O)c3cc(-c4ccc(F)cc4)nc4ccccc34)CC1)O2 CHEMBL4800274 IC50 9.4 nM
COc1ccc2ccc(C(=O)N3CCC4(CC3)Cc3cn(C(C)(C)C)nc3C(=O)N4)cc2n1 CHEMBL2419596 IC50 10.0 nM
CC(C)n1ncc2c1C(=O)CC1(CCN(C(=O)c3ccc4[nH]c(C(N)=O)cc4c3)CC1)C2 CHEMBL2323629 IC50 11.0 nM
CC(C)(C)n1cc2c(n1)C(=O)NC1(CCN(C(=O)c3cnc4c(Cl)c[nH]c4c3)CC1)C2 CHEMBL2419594 IC50 11.0 nM
COc1nccc2ccc(C(=O)N3CCC4(CC3)Cc3cn(C(C)(C)C)nc3C(=O)N4)cc12 CHEMBL2419597 IC50 11.0 nM
CC(=O)NC(C)c1ccc2sc(-c3ccc(Oc4cccc(OCC5CC5)c4)cc3)cc2c1 CHEMBL4083131 IC50 11.0 nM
CC(C)(C)n1cc2c(n1)C(=O)CC1(CCN(C(=O)c3cc(-c4ccncc4)nc4ccccc34)CC1)O2 CHEMBL4791989 IC50 11.31 nM
CC(C)n1ncc2c1C(=O)CC1(CCN(C(=O)c3ccc4ccc(N)nc4c3)CC1)C2 CHEMBL2323627 IC50 12.0 nM
COc1cc(C(=O)N2CCC3(CC2)CC(=O)c2c(cnn2C(C)C)C3)cc(-c2ccc(C(=O)O)cc2)n1 CHEMBL4567446 IC50 12.4 nM
CCCOc1cccc(Oc2ccc(-c3ccc(C(C)NC(C)=O)cc3)cc2)c1 CHEMBL567291 IC50 13.0 nM
CC(C)(C)n1cc2c(n1)C(=O)NC1(CCN(C(=O)c3ccc4[nH]cc(Cl)c4c3)CC1)C2 CHEMBL2419592 IC50 13.0 nM
CC(C)(C)n1cc2c(n1)C(=O)CC1(CCN(C(=O)c3cc(-c4ccccn4)nc4ccccc34)CC1)O2 CHEMBL4779539 IC50 13.84 nM
CC(=O)NC(C)c1ccc(-c2ccc(Oc3ccc(Oc4ccccc4)cc3)cc2)cc1 CHEMBL567281 IC50 14.0 nM
COc1cc(C(=O)N2CCC3(CC2)Cc2cn(C(C)(C)C)nc2C(=O)N3)nc2c(OC)cccc12 CHEMBL3699877 IC50 15.0 nM
CCN(C)c1ccc2ccc(C(=O)N3CCC4(CC3)Cc3cn(C(C)(C)C)nc3C(=O)N4)cc2n1 CHEMBL3699915 IC50 15.0 nM
CC(=O)NC(C)c1ccc(OCc2c(F)cc(Oc3cccc(OCC4CC4)c3)cc2F)cc1 CHEMBL4742115 IC50 15.0 nM
CN(C)c1cc(C(=O)N2CCC3(CC2)CC(=O)c2nn(C(C)(C)C)cc2O3)cc(-c2ccc(C(=O)O)cc2)n1 CHEMBL4762472 pIC50 15.85 nM
CC(=O)NC(C)c1ccc(-c2ccc(Oc3ccc(OC(C)C)cc3)cc2C)cc1 CHEMBL565818 IC50 16.0 nM
CC(=O)NC(C)c1ccc(-c2ccc(Oc3ccc(OC(C)C)cc3)cc2)cc1 CHEMBL567936 IC50 17.0 nM
CCCOc1ccc(Oc2ccc(-c3ccc(C(C)NC(C)=O)cc3)cc2)cc1 CHEMBL567935 IC50 17.0 nM
CC(C)(C)n1cc2c(n1)C(=O)NC1(CCN(C(=O)c3ccc4[nH]nc(Cl)c4c3)CC1)C2 CHEMBL2419591 IC50 17.0 nM
COc1cc(C(=O)N2CCC3(CC2)Cc2cn(C(C)(C)C)nc2C(=O)N3)cc2[nH]ncc12 CHEMBL3699889 IC50 17.0 nM
COc1cc(C(=O)N2CCC3(CC2)Cc2cn(C(C)(C)C)nc2C(=O)N3)cc2c(C)n[nH]c12 CHEMBL3699903 IC50 17.0 nM
CC(C)(C)n1cc2c(n1)C(=O)NC1(CCN(C(=O)c3ccc4ccnc(NC5CCC5)c4c3)CC1)C2 CHEMBL3699924 IC50 17.0 nM
CCNc1nccc2ccc(C(=O)N3CCC4(CC3)Cc3cn(C(C)(C)C)nc3C(=O)N4)cc12 CHEMBL3699927 IC50 17.0 nM
CC(=O)NC(C)c1ccc(OCc2c(F)cc(Oc3cccc(OCC4CC4)c3)cc2F)nc1 CHEMBL4762802 IC50 17.0 nM
CC(C)(C)n1cc2c(n1)C(=O)CC1(CCN(C(=O)c3ccc4[nH]ncc4c3)CC1)O2 CHEMBL2419601 IC50 17.28 nM
CNc1nccc2ccc(C(=O)N3CCC4(CC3)Cc3cn(C(C)(C)C)nc3C(=O)N4)cc12 CHEMBL2419599 IC50 18.0 nM
COc1cccc2ncc(C(=O)N3CCC4(CC3)Cc3cn(C(C)(C)C)nc3C(=O)N4)cc12 CHEMBL3699896 IC50 18.0 nM
COc1cc(C(=O)N2CCC3(CC2)CC(=O)c2nn(C(C)(C)C)cc2O3)cc(-c2ccc(C(=O)O)cc2)n1 CHEMBL4743101 pIC50 19.95 nM
CC(=O)N[C@@H](C)c1cc(-c2cnc(Oc3ccc(OC(C)C)cc3)s2)no1 CHEMBL221169 IC50 20.0 nM
CC(C)Nc1nccc2ccc(C(=O)N3CCC4(CC3)Cc3cn(C(C)(C)C)nc3C(=O)N4)cc12 CHEMBL3699922 IC50 20.0 nM
CCNC(=O)Nc1sc2c(OC)cccc2c1C(=O)N1CCC(N2CCCC3(C2)C(=O)N2CCCCN2C3=O)CC1 CHEMBL2059303 IC50 21.0 nM
CC1=CC(C(=O)N2CCC3(CC2)Cc2cn(CC(C)(C)O)nc2C(=O)N3)=CC2C(C)=NNC12 CHEMBL3699873 IC50 21.0 nM
CC(C)(C)n1cc2c(n1)C(=O)NC1(CCN(C(=O)c3ccc4[nH]nc(C(N)=O)c4c3)CC1)C2 CHEMBL3699880 IC50 21.0 nM
COc1cccc2c(C(=O)N3CCC(N4CCCC5(C4)C(=O)N4CCCCN4C5=O)CC3)c(NC(N)=O)sc12 CHEMBL2059301 IC50 22.0 nM
CCNC(=O)Nc1sc2ccccc2c1C(=O)N1CCC(N2CCCC3(C2)C(=O)N2CCCCCCN2C3=O)CC1 CHEMBL2059099 IC50 22.0 nM
CCC(C)(C)n1cc2c(n1)C(=O)NC1(CCN(C(=O)c3cc(C)c4[nH]nc(C)c4c3)CC1)C2 CHEMBL2419607 IC50 23.0 nM
COc1cc(C(=O)N2CCC3(CC2)Cc2cn(C(C)(C)C)nc2C(=O)N3)cc2cn[nH]c12 CHEMBL3699825 IC50 23.0 nM
CC(=O)NC(C)c1ccc2nc(N3CC(Oc4cccc(OCC5CC5)c4)C3)oc2c1 CHEMBL4086054 IC50 23.0 nM
CCCNc1nccc2ccc(C(=O)N3CCC4(CC3)Cc3cn(C(C)(C)C)nc3C(=O)N4)cc12 CHEMBL3699925 IC50 24.0 nM
Cc1n[nH]c2c(C)cc(C(=O)N3CCC4(CC3)Cc3cnn(C(C)C)c3C(=O)N4)cc12 CHEMBL2419609 IC50 24.2 nM
CNC(=O)Nc1sc2c(OC)cccc2c1C(=O)N1CCC(N2CCCC3(C2)C(=O)N2CCCCN2C3=O)CC1 CHEMBL2059302 IC50 25.0 nM
CC1=CC(C(=O)N2CCC3(CC2)Cc2cn(C(C)(C)C)nc2C(=O)N3)=CC2C=NNC12 CHEMBL3699870 IC50 26.0 nM
Cc1nc2ccc(C(=O)N3CCC4(CC3)CC(=O)c3c(cnn3C(C)C)C4)cc2[nH]1 CHEMBL3359265 IC50 27.0 nM
Cc1[nH]nc2c(C)cc(C(=O)N3CCC4(CC3)Cc3cnn(C(C)(C)C)c3C(=O)N4)cc12 CHEMBL2419608 IC50 27.0 nM
COCCNc1ccc2ccc(C(=O)N3CCC4(CC3)Cc3cn(C(C)(C)C)nc3C(=O)N4)cc2n1 CHEMBL3699917 IC50 27.0 nM
CC(=O)NC(C)C#Cc1cnc(Oc2ccc(OCC3CCCC3)cc2)s1 CHEMBL220563 IC50 28.0 nM
Cc1n[nH]c2c(C)cc(C(=O)N3CCC4(CC3)Cc3cn(C(C)(C)C)nc3C(=O)N4)cc12 CHEMBL2419604 IC50 28.0 nM
CC(C)(C)n1cc2c(n1)C(=O)NC1(CCN(C(=O)c3ccc4ccc(N)nc4c3)CC1)C2 CHEMBL3699894 IC50 28.0 nM
CC(=O)NC(C)C#Cc1ccc(Oc2ccc(OC(C)C)cc2)cc1 CHEMBL212460 IC50 29.0 nM
CC1=CC(C(=O)N2CCC3(CC2)Cc2cn(C(C)C)nc2C(=O)N3)=CC2C(C)=NNC12 CHEMBL3699869 IC50 29.0 nM
CC(C)(C)n1cc2c(n1)C(=O)NC1(CCN(C(=O)c3ccc4ccnc(NC5CC5)c4c3)CC1)C2 CHEMBL3699921 IC50 29.0 nM
COc1ccc2ncc(C(=O)N3CCC4(CC3)Cc3cn(C(C)(C)C)nc3C(=O)N4)cc2c1 CHEMBL3699874 IC50 30.0 nM
COc1cccc2cc(C(=O)N3CCC4(CC3)Cc3cn(C(C)(C)C)nc3C(=O)N4)ccc12 CHEMBL3699876 IC50 30.0 nM
CC(=O)NC(C)c1ccc(OCc2c(F)cc(Oc3cccc(OCC4CC4)c3)cc2F)nn1 CHEMBL4764202 IC50 31.0 nM
CCNC(=O)Nc1sc2ccccc2c1C(=O)N1CCC(N2CCC[C@@]3(C2)CC(C)(C)OC3=O)CC1 CHEMBL1910404 IC50 32.0 nM
Cc1cc(C(=O)N2CCC3(CC2)CC(=O)c2nn(C(C)(C)C)cc2O3)cc2cn[nH]c12 CHEMBL1958360 IC50 32.0 nM
CNc1ccc2ccc(C(=O)N3CCC4(CC3)Cc3cnn(C(C)C)c3C(=O)N4)cc2n1 CHEMBL3699855 IC50 33.0 nM
CC(=O)NC(C)c1ccc(-c2ccc(Oc3ccc(C(=O)c4ccccc4)cc3)cc2)cc1 CHEMBL565418 IC50 35.0 nM
CCCOc1ccc(Oc2ccc(-c3ccc([C@H](C)NC(C)=O)cc3)cn2)cc1 CHEMBL566024 IC50 35.0 nM
COC1=CC(C(=O)N2CCC3(CC2)Cc2cnn(C(C)C)c2C(=O)N3)=CC2NN=CC12 CHEMBL3699838 IC50 35.0 nM
CC(=O)N[C@@H](C)/C=C/c1ccc(Oc2ccc3nc(C(C)C)sc3c2F)nc1 CHEMBL4229067 IC50 35.0 nM
CCCOc1cccc(Oc2ccc(-c3ccc(C(C)NC(=O)c4cn[nH]c4)cc3)cc2)c1 CHEMBL568145 IC50 36.0 nM
COc1ccc2cc(C(=O)N3CCC4(CC3)Cc3cn(C(C)(C)C)nc3C(=O)N4)ccc2c1 CHEMBL3699872 IC50 36.0 nM
CC(=O)NC(C)c1ccc(OCc2c(F)cc(Oc3cccc(OCC4CC4)c3)cc2F)cn1 CHEMBL4755102 IC50 38.0 nM
CC(=O)NC(C)c1ccc(-c2ccc(Oc3ccc(Cc4ccccc4)cc3)cc2)cc1 CHEMBL568155 IC50 39.0 nM
CC(=O)NC(C)c1ccc(Oc2ccc(Oc3cccc(OCC4CC4)c3)cc2)cc1 CHEMBL4746516 IC50 39.0 nM
CC(C)(C)n1ncc2c1C(=O)CC1(CCN(C(=O)c3ccc4[nH]ncc4c3)CC1)C2 CHEMBL3359261 IC50 40.0 nM
CC(=O)NC(C)c1ccc(-c2ccc(Oc3cccc(Oc4ccccc4)c3)cc2)cc1 CHEMBL585885 IC50 41.0 nM
CCN1C(=O)C2(CCCN(C3CCN(C(=O)c4c(NC(=O)NC)sc5ccccc45)CC3)C2)C(=O)N1CC CHEMBL2059093 IC50 41.0 nM
CC(C)n1ncc2c1C(=O)CC1(CCN(C(=O)c3cnc4cc[nH]c4c3)CC1)C2 CHEMBL3359264 IC50 41.0 nM
CC(C)(C)n1cc2c(n1)C(=O)NC1(CCN(C(=O)c3ccc4[nH]nc(C(F)(F)F)c4c3)CC1)C2 CHEMBL2419590 IC50 42.0 nM
CCNC(=O)Nc1sc2ccccc2c1C(=O)N1CCC(N2CCCC3(C2)C(=O)N2CCCCCN2C3=O)CC1 CHEMBL2059098 IC50 43.0 nM
Cc1cc(C(=O)N2CCC3(CC2)Cc2cnn(C(C)C)c2C(=O)N3)cc2c[nH]nc12 CHEMBL3699831 IC50 43.0 nM
CC(C)(C)n1cc2c(n1)C(=O)NC1(CCN(C(=O)c3ccc4[nH]nc(C#N)c4c3)CC1)C2 CHEMBL3699884 IC50 43.0 nM
CO[C@]1(C(F)(F)F)CC[C@]2(CC1)NC(=O)C(c1cc(-c3ccc(Cl)cc3)ccc1C)=C2O CHEMBL3967050 IC50 44.0 nM
COc1n[nH]c2ccc(C(=O)N3CCC4(CC3)Cc3cn(C(C)(C)C)nc3C(=O)N4)cc12 CHEMBL3699901 IC50 46.0 nM
CCCOc1ccc(Oc2ccc(-c3ccc(C(C)NC(=O)CC)cc3)cc2)cc1 CHEMBL566680 IC50 47.0 nM
CC(C)(C)n1cc2c(n1)C(=O)NC1(CCN(C(=O)c3ccc4c(C#N)n[nH]c4c3)CC1)C2 CHEMBL3699879 IC50 47.0 nM
COCCNc1nccc2ccc(C(=O)N3CCC4(CC3)Cc3cn(C(C)(C)C)nc3C(=O)N4)cc12 CHEMBL3699926 IC50 47.0 nM
CNC(=O)Nc1sc2nc(C)ccc2c1C(=O)N1CCC(N2CCC[C@@]3(C2)CC(C)(C)OC3=O)CC1 CHEMBL2030573 IC50 48.0 nM
CNC(=O)Nc1sc2ccccc2c1C(=O)N1CCC(N2CCCC3(C2)C(=O)N2CCCCCN2C3=O)CC1 CHEMBL2059097 IC50 48.0 nM
CNc1cc2cc(C(=O)N3CCC4(CC3)Cc3cn(C(C)(C)C)nc3C(=O)N4)ccc2cn1 CHEMBL3699895 IC50 48.0 nM
CC(=O)NC(C)c1ccc(-c2ccc(Oc3cccc(Oc4ccccc4)c3)nc2)cc1 CHEMBL585491 IC50 49.0 nM
Cc1n[nH]c2c(C)cc(C(=O)N3CCC4(CC3)Cc3cn(C5CCC5)nc3C(=O)N4)cc12 CHEMBL2419606 IC50 49.0 nM
CO[C@]1(C)CC[C@]2(CC1)NC(=O)C(c1cc(-c3ccc(Cl)cc3)ccc1C)=C2O CHEMBL3975394 IC50 55.0 nM
CC(=O)NC(C)C#Cc1cnc(Oc2cccc(OC3CCCCC3)c2)s1 CHEMBL375116 IC50 56.0 nM
CC(=O)NC(C)c1ccc(-c2ccc(Oc3ccc(OCc4ccccc4)cc3)nc2)cc1 CHEMBL567700 IC50 58.0 nM
Cc1ccc(-c2ccc(Cl)c(F)c2)cc1C1=C(O)[C@]2(CC[C@H](C(F)(F)F)CC2)NC1=O CHEMBL3934157 IC50 59.0 nM
CC(=O)NC(C)c1ccc(-c2ccc(Oc3cccc(OCC4CC4)c3)cc2)cc1 CHEMBL4794153 IC50 60.0 nM
CC(C)n1ncc2c1C(=O)CC1(CCN(C(=O)c3ccc4[nH]ncc4c3)CC1)C2 CHEMBL3359262 IC50 62.0 nM
Cc1cc(C(=O)N2CCC3(CC2)Cc2cnn(C(C)(C)C)c2C(=O)N3)cc2c[nH]nc12 CHEMBL3699834 IC50 62.0 nM
CC(C)(C)n1cc2c(n1)C(=O)NC1(CCN(C(=O)c3cnc4[nH]cc(Cl)c4c3)CC1)C2 CHEMBL3699911 IC50 62.0 nM
CC(C)(C)n1cc2c(n1)C(=O)NC1(CCN(C(=O)c3ccc4ccnc(N)c4c3)CC1)C2 CHEMBL3699826 IC50 62.0 nM
CCNC(=O)Nc1sc2ccccc2c1C(=O)N1CCC(N2CCCC3(C2)CC(C)(C)OC3=O)CC1 CHEMBL1910400 IC50 63.0 nM
CO[C@]1(C)CC[C@]2(CC1)NC(=O)C(c1cc(-c3ccc(Cl)c(F)c3)ccc1C)=C2O CHEMBL3899063 IC50 63.0 nM
CNc1n[nH]c2ccc(C(=O)N3CCC4(CC3)Cc3cn(C(C)(C)C)nc3C(=O)N4)cc12 CHEMBL3699908 IC50 65.0 nM
CC(=O)NC(C)C#Cc1cnc(Oc2cccc(OC(C)C)c2)s1 CHEMBL220031 IC50 66.0 nM
CNc1cccc2ccc(C(=O)N3CCC4(CC3)Cc3cnn(C(C)C)c3C(=O)N4)cc12 CHEMBL3699862 IC50 67.0 nM
CC1=CC(C(=O)N2CCC3(CC2)Cc2cn(C(C)C)nc2C(=O)N3)=CC2C=NNC12 CHEMBL3699868 IC50 68.0 nM
CCCOc1ccc(Oc2ccc(-c3ccc(C(C)NC(=O)CCC)cc3)cn2)cc1 CHEMBL566862 IC50 69.0 nM
CC(=O)NC(C)c1ccc(OCc2ccc(Oc3cccc(OCC4CC4)c3)cc2F)cc1 CHEMBL4740125 IC50 69.0 nM
CC(=O)NC(C)C#Cc1cnc(Oc2cccc(OCC(C)C)c2)s1 CHEMBL220230 IC50 72.0 nM
COc1cc(C(=O)N2CCC3(CC2)Cc2cnn(C(C)C)c2C(=O)N3)cc2c(OC)cccc12 CHEMBL3699843 IC50 72.0 nM
CC(C)(C)n1cc2c(n1)C(=O)NC1(CCN(C(=O)c3ccc4ccnc(Cl)c4c3)CC1)C2 CHEMBL3699828 IC50 73.0 nM
COC[C@H]1CC[C@]2(CC1)NC(=O)C(c1cc(-c3ccc(Cl)c(F)c3)ccc1C)=C2O CHEMBL3902871 IC50 73.0 nM
COc1cc2cc(C(=O)N3CCC4(CC3)Cc3cn(C(C)(C)C)nc3C(=O)N4)ccc2cn1 CHEMBL2419595 IC50 74.0 nM
CCNC(=O)Nc1sc2nc(C)ccc2c1C(=O)N1CCC(N2CCCC3(C2)N=C(C)N(C(C)C)C3=O)CC1 CHEMBL2030577 IC50 76.0 nM
CCNC(=O)Nc1sc2nc(C)ccc2c1C(=O)N1CCC(N2CCCC3(C2)CC(C)(C)OC3=O)CC1 CHEMBL2030570 IC50 78.0 nM
CC(C)(C)Nc1nccc2ccc(C(=O)N3CCC4(CC3)Cc3cn(C(C)(C)C)nc3C(=O)N4)cc12 CHEMBL3699830 IC50 78.0 nM
CNc1nc2cc(C(=O)N3CCC4(CC3)Cc3cn(C(C)(C)C)nc3C(=O)N4)ccc2[nH]1 CHEMBL3699897 IC50 79.0 nM
CCN1C(=O)C2(CCCN(C3CCN(C(=O)c4c(NC(N)=O)sc5ccccc45)CC3)C2)N=C1C(C)C CHEMBL2030564 IC50 80.0 nM
CC(C)(C)n1cc2c(n1)C(=O)NC1(CCN(C(=O)c3ccc4[nH]c(N)nc4c3)CC1)C2 CHEMBL3699898 IC50 80.0 nM
CCCc1ccc(Oc2ccc(-c3ccc(C(C)NC(C)=O)cc3)cc2)cc1 CHEMBL567934 IC50 81.0 nM
CC1(C)CC2(CCCN(C3CCN(C(=O)c4c(NC(N)=O)sc5ccccc45)CC3)C2)C(=O)O1 CHEMBL1910398 IC50 84.0 nM
CO[C@H]1CC[C@]2(C=C(c3cc(-c4ccc(Cl)cc4)ccc3C)C(=O)N2)CC1 CHEMBL3968401 IC50 84.0 nM
COC[C@]1(OC)CC[C@@]2(CC1)NC(=O)C(c1cc(-c3ccc(Cl)c(F)c3)ccc1C)=C2O CHEMBL3981327 IC50 84.0 nM
CC(=O)NC(C)C#Cc1cnc(Oc2ccc(OCC3CCCCC3)cc2)s1 CHEMBL219948 IC50 86.0 nM
CC(C)n1ncc2c1C(=O)NC1(CCN(C(=O)C3=CC4C=NNC4C(Cl)=C3)CC1)C2 CHEMBL3699837 IC50 88.0 nM
CC(C)(C)n1cc2c(n1)C(=O)NC1(CCN(C(=O)c3ccc4cn[nH]c4c3)CC1)C2 CHEMBL3699878 IC50 88.0 nM
COCCc1ccc(Oc2ccc(-c3ccc(C(C)NC(C)=O)cc3)cc2)cc1 CHEMBL565627 IC50 89.0 nM
CC(C)(C)n1cc2c(n1)C(=O)NC1(CCN(C(=O)c3ccc4ccc(Cl)nc4c3)CC1)C2 CHEMBL3699829 IC50 89.0 nM
CC(=O)NC(C)c1cnc(OCc2c(F)cc(Oc3cccc(OCC4CC4)c3)cc2F)cn1 CHEMBL4796473 IC50 89.0 nM
Cc1n[nH]c2c(C)cc(C(=O)N3CCC4(CC3)Cc3cn(C(C)C)nc3C(=O)N4)cc12 CHEMBL2419605 IC50 91.0 nM
CO[C@]1(C(F)(F)F)CC[C@]2(CC1)NC(=O)C(c1cc(-c3ccc(Cl)c(F)c3)ccc1C)=C2O CHEMBL3892266 IC50 92.0 nM
COC[C@H]1CC[C@]2(CC1)NC(=O)C(c1cc(-c3ccc(Cl)cc3)ccc1C)=C2O CHEMBL3896396 IC50 92.0 nM
CC(=O)NC(C)c1cc(-c2cnc(Oc3ccc(OC(C)C)cc3)s2)no1 CHEMBL220271 IC50 93.0 nM
CCNC(=O)Nc1sc2nc(C)ccc2c1C(=O)N1CCC(N2CCC[C@]3(CCN(C(C)C)C3=O)C2)CC1 CHEMBL2030574 IC50 93.0 nM
CC(C)(C)n1cc2c(n1)C(=O)NC1(CCN(C(=O)c3ccc4[nH]nc(N)c4c3)CC1)C2 CHEMBL3699885 IC50 94.0 nM
CNC(=O)Nc1sc2ccccc2c1C(=O)N1CCC(N2CCCC3(C2)CC(C)(C)OC3=O)CC1 CHEMBL1910399 IC50 95.0 nM
COc1nccc2ccc(C(=O)N3CCC4(CC3)Cc3cnn(C(C)C)c3C(=O)N4)cc12 CHEMBL3699856 IC50 98.0 nM
CCCCCc1cccc(OC2CN(c3nc4ccc(C(C)NC(C)=O)cc4o3)C2)c1 CHEMBL4082568 IC50 100.0 nM
CC(=O)N1CCC(C(=O)N2CCC(N3CCN(C(=O)c4cc(-c5ccc(C)cc5)nc(-c5ccc(C)cc5)c4)CC3)CC2)CC1 CHEMBL1076223 IC50 101.0 nM
CO[C@H]1CC[C@]2(CC1)NC(=O)C(c1cc(-c3ccc(Cl)c(F)c3)ccc1C)=C2O CHEMBL3906239 IC50 102.0 nM
CNc1cc2ccc(C(=O)N3CCC4(CC3)Cc3cn(C(C)(C)C)nc3C(=O)N4)cc2cn1 CHEMBL3699910 IC50 105.0 nM
Cc1ccc(-c2ccc(Cl)cc2)cc1C1=C(O)[C@]2(CC[C@H](C(F)(F)F)CC2)NC1=O CHEMBL3904572 IC50 109.0 nM
CCCOc1ccc(Oc2ccc(-c3ccc(C(C)NC(C)=O)cc3)cn2)cc1 CHEMBL585578 IC50 110.0 nM
CCNC(=O)Nc1sc2ncccc2c1C(=O)N1CCC(N2CCCC3(C2)CC(C)(C)OC3=O)CC1 CHEMBL2030569 IC50 110.0 nM
CC(C)n1ncc2c1C(=O)NC1(CCN(C(=O)C3=CC4C(Cl)=NNC4C=C3)CC1)C2 CHEMBL3699860 IC50 116.0 nM
CC(C)(C)n1cc2c(n1)C(=O)NC1(CCN(C(=O)c3ccc4[nH]ncc4c3)CC1)C2 CHEMBL2419603 IC50 118.0 nM
CC1=NNC2C=CC(C(=O)N3CCC4(CC3)Cc3cnn(C(C)C)c3C(=O)N4)=CC12 CHEMBL3699842 IC50 118.0 nM
CC(=O)NC(C)C#Cc1cnc(Oc2ccc(OC3CCCCC3)cc2)s1 CHEMBL220668 IC50 120.0 nM
CNC(=O)Nc1sc2ccccc2c1C(=O)N1CCC(N2CCCC3(CCN(C(C)C)C3=O)C2)CC1 CHEMBL2030568 IC50 120.0 nM
CCNC(=O)Nc1sc2ccccc2c1C(=O)N1CCC(N2CCCC3(C2)C(=O)N(C)N(C)C3=O)CC1 CHEMBL2059092 IC50 120.0 nM
CCCCOc1cccc(Oc2ccc(-c3ccc(C(C)NC(C)=O)cc3)cc2)c1 CHEMBL4757670 IC50 120.0 nM
COc1ccc2ncc(C(=O)N3CCC4(CC3)Cc3cnn(C(C)C)c3C(=O)N4)cc2c1 CHEMBL3699852 IC50 121.0 nM
CC(C)(C)n1cc2c(n1)C(=O)NC1(CCN(C(=O)c3ccc4cnc(N)cc4c3)CC1)C2 CHEMBL3699883 IC50 123.0 nM
CC(C)(C)n1cc2c(n1)C(=O)CC1(CCN(C(=O)c3ccc4[nH]nc(C(=O)O)c4c3)CC1)O2 CHEMBL4759617 pIC50 125.89 nM
CCNC(=O)Nc1sc2ccccc2c1C(=O)N1CCC(N2CCCC3(C2)C(=O)N2CCCCN2C3=O)CC1 CHEMBL2059096 IC50 130.0 nM
CC(C)(C)n1cc2c(n1)C(=O)NC1(CCN(C(=O)c3ccc4cc(N)ncc4c3)CC1)C2 CHEMBL3699909 IC50 130.0 nM
CCn1cc(C(=O)Nc2ccc3[nH]ncc3c2)c2ncc(-c3ccccc3)cc21 CHEMBL4455121 IC50 130.0 nM
COCCc1cccc(Oc2ccc(-c3ccc(C(C)NC(C)=O)cc3)cc2)c1 CHEMBL4756960 IC50 130.0 nM
CCC1=CC(C(=O)N2CCC3(CC2)Cc2cnn(C(C)C)c2C(=O)N3)=CC2C=NNC12 CHEMBL3699840 IC50 131.0 nM
CCCOc1ccc(Oc2ncc(C#CC(C)NC(C)=O)s2)cc1 CHEMBL223100 IC50 140.0 nM
CC(=O)NC(C)c1ccc(-c2ccc(Oc3ccc(-c4c(O)ccc5c4CCCC5)cc3)cc2)cc1 CHEMBL565839 IC50 140.0 nM
CC(=O)N[C@@H](C)CC[C@H]1CC[C@H](Oc2ccc(OC(C)C)nc2)CC1 CHEMBL1630721 IC50 140.0 nM
CC(=O)NC(C)c1cccc(OCc2ccc(Oc3cccc(OCC4CC4)c3)cc2)c1 CHEMBL4062997 IC50 140.0 nM
COC[C@]1(OC)CC[C@@]2(CC1)NC(=O)C(c1cc(-c3ccc(Cl)cc3)ccc1C)=C2O CHEMBL3964494 IC50 146.0 nM
CC(C)(C)n1cc2c(n1)C(=O)NC1(CCN(C(=O)c3ccc4nc(N)ccc4c3)CC1)C2 CHEMBL3699882 IC50 149.0 nM
CCNC(=O)Nc1sc2cccnc2c1C(=O)N1CCC(N2CCCC3(C2)CC(C)(C)OC3=O)CC1 CHEMBL2030571 IC50 150.0 nM
CCNC(=O)Nc1sc2nccnc2c1C(=O)N1CCC(N2CCCC3(C2)CC(C)(C)OC3=O)CC1 CHEMBL2030572 IC50 150.0 nM
CCNC(=O)Nc1sc2nc(C)ccc2c1C(=O)N1CCC(N2CCCC3(C2)NC(=O)N(C(C)C)C3=O)CC1 CHEMBL2030578 IC50 150.0 nM
CC(C)n1cc(C(=O)Nc2cc3cn[nH]c3cc2F)c2ncc(-c3ccc(N)cc3)cc21 CHEMBL4586472 IC50 150.0 nM
CC(C)n1ncc2c1C(=O)NC1(CCN(C(=O)C3=CC4NC=C(Cl)C4N=C3)CC1)C2 CHEMBL3699858 IC50 154.0 nM
CC(C)(C)n1cc2c(n1)C(=O)NC1(CCN(C(=O)c3cc(C(F)(F)F)c4[nH]ncc4c3)CC1)C2 CHEMBL3699899 IC50 155.0 nM
COc1ccc2ccc(C(=O)N3CCC4(CC3)Cc3cnn(C(C)C)c3C(=O)N4)cc2n1 CHEMBL3699854 IC50 158.0 nM
CNC(=O)Nc1sc2nc(C)ccc2c1C(=O)N1CCC(N2CCC[C@]3(CC(=O)N(C(C)C)C3=O)C2)CC1 CHEMBL2030575 IC50 160.0 nM
CCNC(=O)Nc1sc2nc(C)ccc2c1C(=O)N1CCC(N2CCCC3(C2)OC(=O)N(C(C)C)C3=O)CC1 CHEMBL2030576 IC50 160.0 nM
CC(C)(C)n1cc2c(n1)C(=O)NC1(CCN(C(=O)c3ccc4ncccc4c3)CC1)C2 CHEMBL3699887 IC50 160.0 nM
CC(C)(C)n1cc2c(n1)C(=O)NC1(CCN(C(=O)c3ccc4c(N)nccc4c3)CC1)C2 CHEMBL3699827 IC50 160.0 nM
CC(C)(C)n1cc2c(n1)C(=O)NC1(CCN(C(=O)c3ccc4c(C(F)(F)F)n[nH]c4c3)CC1)C2 CHEMBL3639987 IC50 163.0 nM
CC(C)(C)n1cc2c(n1)C(=O)NC1(CCN(C(=O)C3=CC4C=NNC4C=C3)CC1)C2 CHEMBL3699867 IC50 164.0 nM
CCNC(=O)Nc1sc2ccccc2c1C(=O)N1CCC(N2CCCC3(C2)C(=O)N2CCCN2C3=O)CC1 CHEMBL2059094 IC50 170.0 nM
CC(C)n1ncc2c1C(=O)NC1(CCN(C(=O)C3=CC4C(Cl)=CNC4N=C3)CC1)C2 CHEMBL3699857 IC50 179.0 nM
CNc1ccc2cc(C(=O)N3CCC4(CC3)Cc3cn(C(C)(C)C)nc3C(=O)N4)ccc2n1 CHEMBL3699892 IC50 185.0 nM
CCCOc1ccc(Oc2ccc(-c3ccc(C(C)NC(=O)C(C)C)cc3)cc2)cc1 CHEMBL568362 IC50 188.0 nM
CC(=O)N[C@@H](C)CCc1ccc(Oc2ccc(OC(C)C)nc2)cc1 CHEMBL1630715 IC50 190.0 nM
CCNC(=O)Nc1sc2ccccc2c1C(=O)N1CCC(N2CCCC3(C2)OC(=O)N(CC)C3=O)CC1 CHEMBL2030409 IC50 190.0 nM
CCNC(=O)Nc1sc2cc(C)ccc2c1C(=O)N1CCN(C2CCN(C(=O)C(C)(C)C(F)(F)F)CC2)CC1 CHEMBL1683796 IC50 192.0 nM
CCOc1ccc(N2CCN(c3noc(C4(NC(C)=O)CCC4)n3)[C@@H](C)C2)c(C)c1 CHEMBL3110076 IC50 193.0 nM
Cn1[nH]c2cc(C(=O)N3CCC4(CC3)Cc3cn(C(C)(C)C)nc3C(=O)N4)ccc2c1=O CHEMBL3699902 IC50 194.0 nM
CNC(=O)Nc1sc2ccccc2c1C(=O)N1CCC(N2CCCC3(C2)C(=O)N2CCCCN2C3=O)CC1 CHEMBL2059095 IC50 200.0 nM
COc1cc2ccc(C(=O)N3CCC4(CC3)Cc3cn(C(C)(C)C)nc3C(=O)N4)cc2cn1 CHEMBL3699905 IC50 209.0 nM
CC(=O)NC(C)c1cnc(-c2cnc(Oc3ccc(OC(C)C)cc3)s2)s1 CHEMBL219902 IC50 210.0 nM
CCCCOc1cccc(OC2CN(c3nc4ccc(C(C)NC(C)=O)cc4o3)C2)c1 CHEMBL4064532 IC50 210.0 nM
CC(C)n1cc(C(=O)Nc2ccc3[nH]ncc3c2)c2ncc(-c3ccc(N)cc3)cc21 CHEMBL4458032 IC50 210.0 nM
COc1n[nH]c2cc(C(=O)N3CCC4(CC3)Cc3cn(C(C)(C)C)nc3C(=O)N4)ccc12 CHEMBL3699900 IC50 216.0 nM
CC(C)(C)n1cc2c(n1)C(=O)NC1(CCN(C(=O)c3ccc4[nH]nnc4c3)CC1)C2 CHEMBL3699912 IC50 219.0 nM
CC1(C)CC2(CCCN(C3CCN(C(=O)c4c(NC(=O)NC5CCCCC5)sc5ccccc45)CC3)C2)C(=O)O1 CHEMBL1910401 IC50 220.0 nM
CC(=O)NC(C)c1ccc(OCc2ccc(Oc3cccc(OCC4CC4)c3)cc2)cc1 CHEMBL4758263 IC50 220.0 nM
COc1cccc2cc(C(=O)N3CCC4(CC3)Cc3cn(C(C)(C)C)nc3C(=O)N4)cnc12 CHEMBL3699891 IC50 221.0 nM
CC(C)n1ncc2c1C(=O)NC1(CCN(C(=O)c3ccc4n[nH]cc4c3)CC1)C2 CHEMBL3699832 IC50 227.0 nM
CC(=O)NC(C)C#Cc1cnc(Oc2ccc(OCC(C)C)cc2)s1 CHEMBL375532 IC50 230.0 nM
CCNC(=O)Nc1sc2ccccc2c1C(=O)N1CCC(N2CCCC3(CC(=O)N(CC)C3=O)C2)CC1 CHEMBL2030407 IC50 230.0 nM
CC(=O)NC(C)c1ccc2nc(N3CCC(Oc4cccc(OCC5CC5)c4)CC3)oc2c1 CHEMBL4071626 IC50 230.0 nM
CC(C)(C)OC(=O)NC[C@H]1CC[C@H](CNC(=O)c2cc(-c3cccc(CN)c3)nc3ccccc23)CC1 CHEMBL1818291 IC50 240.0 nM
CNc1nccc2cc(C(=O)N3CCC4(CC3)Cc3cn(C(C)(C)C)nc3C(=O)N4)ccc12 CHEMBL3699906 IC50 240.0 nM
CC(=O)N[C@H](C)COc1cnc(-c2ccc(Oc3cccc(OCC4CC4)c3)cc2)o1 CHEMBL4064059 IC50 240.0 nM
COc1nccc2cc(C(=O)N3CCC4(CC3)Cc3cn(C(C)(C)C)nc3C(=O)N4)ccc12 CHEMBL3699907 IC50 244.0 nM
CCC1=NNC2C=CC(C(=O)N3CCC4(CC3)Cc3cnn(C(C)C)c3C(=O)N4)=CC12 CHEMBL3699841 IC50 251.0 nM
CC(C)(C)n1cc2c(n1)C(=O)NC1(CCN(C(=O)c3ccc4c(N)n[nH]c4c3)CC1)C2 CHEMBL3699888 IC50 256.0 nM
CC(C)n1ncc2c1C(=O)NC1(CCN(C(=O)C3=CC4C(C#N)=NNC4C=C3)CC1)C2 CHEMBL3699851 IC50 259.0 nM
CC(=O)NC(C)C#Cc1cnc(Oc2ccc(Oc3ccccc3)cc2)s1 CHEMBL376983 IC50 260.0 nM
CC(C)(C)n1ncc2c1C(=O)NC1(CCN(C(=O)c3ccc4n[nH]cc4c3)CC1)C2 CHEMBL3699833 IC50 269.0 nM
CCNC(=O)Nc1sc2ccccc2c1C(=O)N1CCC(N2CCCC3(C2)NC(=O)N(CC)C3=O)CC1 CHEMBL2030410 IC50 280.0 nM
CCN1C(=O)OC2(CCCN(C3CCN(C(=O)c4c(NC(N)=O)sc5ccccc45)CC3)C2)C1=O CHEMBL2030408 IC50 290.0 nM
CCCOc1ccc(Oc2ccc(-c3ccc(C(C)NC(=O)C4CC4)cc3)cc2)cc1 CHEMBL585108 IC50 296.0 nM
CC(C)n1ncc2c1C(=O)NC1(CCN(C(=O)C3=CC4C(C(N)=O)=NNC4C=C3)CC1)C2 CHEMBL3699853 IC50 296.0 nM
CCN1C(=O)C2(CCCN(C3CCN(C(=O)c4c(NC(N)=O)sc5ccccc45)CC3)C2)N=C1C CHEMBL2030562 IC50 300.0 nM
CNC1=NNC2C=CC(C(=O)N3CCC4(CC3)Cc3cnn(C(C)C)c3C(=O)N4)=CC12 CHEMBL3699863 IC50 302.0 nM
CC(=O)N[C@@H](C)/C=C/c1ccc(Oc2ccc3nc(C(C)C)sc3c2Cl)nc1 CHEMBL4225659 IC50 303.0 nM
CCn1ncc2c1C(=O)CC1(CCN(C(=O)c3ccc4[nH]ncc4c3)CC1)C2 CHEMBL3359263 IC50 317.0 nM
CCCOc1ccc(Oc2ccc(-c3ccc(C(C)NC(=O)C4CC4)cc3)cn2)cc1 CHEMBL567923 IC50 319.0 nM
COC1CCC2(C=C(c3cc(-c4ccc(Cl)c(Cl)c4)ccc3C)C(=O)N2)CC1 CHEMBL3900798 IC50 327.0 nM
CC(C)n1cc2c(n1)C(=O)NC1(CCN(C(=O)C3=CC4C=NNC4C=C3)CC1)C2 CHEMBL3699865 IC50 329.0 nM
CC1(C)CC2(CCCN(C3CCN(C(=O)c4c5ccccc5cc5ccccc45)CC3)C2)C(=O)O1 CHEMBL1910393 IC50 330.0 nM
CCN(C)c1nccc2ccc(C(=O)N3CCC4(CC3)Cc3cn(C(C)(C)C)nc3C(=O)N4)cc12 CHEMBL3699923 IC50 332.0 nM
CC(C)n1ncc2c1C(=O)NC1(CCN(C(=O)c3cnc4ccccc4c3)CC1)C2 CHEMBL3699846 IC50 336.0 nM
CC(=O)NC(C)C#Cc1cnc(Oc2ccc(OCC(C)C)cc2F)s1 CHEMBL233004 IC50 340.0 nM
CNc1n[nH]c2cc(C(=O)N3CCC4(CC3)Cc3cn(C(C)(C)C)nc3C(=O)N4)ccc12 CHEMBL3699904 IC50 343.0 nM
CCN1C(=O)CC2(CCCN(C3CCN(C(=O)c4c(NC(N)=O)sc5ccccc45)CC3)C2)C1=O CHEMBL2030406 IC50 350.0 nM
CCNC(=O)Nc1sc2ccccc2c1C(=O)N1CCC(N2CCCC3(CCN(CC)C3=O)C2)CC1 CHEMBL2030567 IC50 350.0 nM
CC(C)Oc1ccc(Oc2ccc(CC[C@H](C)NC(=O)C3CC3)cc2)cn1 CHEMBL1630701 IC50 360.0 nM
CCNC(=O)Nc1sc2ccccc2c1C(=O)N1CCC(N2CCCC3(C2)C(=O)N(CC)C(=O)N3C)CC1 CHEMBL2030411 IC50 360.0 nM
CNc1cc2ccc(C(=O)N3CCC4(CC3)Cc3cnn(C(C)C)c3C(=O)N4)cc2cn1 CHEMBL3699864 IC50 364.0 nM
CC(=O)NC(C)C#Cc1cnc(Oc2ccc(SC(C)C)cc2)s1 CHEMBL377535 IC50 370.0 nM
CCOc1ccc(N2CCN(c3noc([C@H](C)NC(C)=O)n3)[C@@H](C)C2)c(C)c1 CHEMBL3110092 IC50 386.0 nM
CC(=O)NC(C)C#Cc1cnc(Oc2ccc(OC(C)C)nc2)s1 CHEMBL208680 IC50 390.0 nM
CC(C)(C)n1cc2c(n1)C(=O)CC1(CCN(C(=O)c3cccc(-c4ccc(C(=O)O)cc4)c3)CC1)O2 CHEMBL4777931 pIC50 398.11 nM
CC(C)n1ncc2c1C(=O)NC1(CCN(C(=O)C3=CC4NC=CC4N=C3)CC1)C2 CHEMBL3699836 IC50 403.0 nM
O=C(c1c2ccccc2cc2ccccc12)N1CCC(N2CCC[C@@H](C(=O)N3CCOCC3)C2)CC1 CHEMBL208943 IC50 410.0 nM
CCC1=NC2(CCCN(C3CCN(C(=O)c4c(NC(N)=O)sc5ccccc45)CC3)C2)C(=O)N1CC CHEMBL2030563 IC50 410.0 nM
CC(=O)NC(C)c1ccc(-c2ccc(Oc3ccc(OC(C)C)cc3)nc2)cc1 CHEMBL566681 IC50 415.0 nM
Cc1nc2cc(C(=O)N3CCC4(CC3)Cc3cnn(C(C)C)c3C(=O)N4)ccc2[nH]1 CHEMBL3699823 IC50 417.0 nM
Cn1cc(C(=O)Nc2ccc3[nH]ncc3c2)c2ncc(-c3ccccc3)cc21 CHEMBL4586331 IC50 430.0 nM
CCCOc1ccc(Oc2ccc(-c3ccc(C(C)NC(=O)C(C)C)cc3)cn2)cc1 CHEMBL586039 IC50 451.0 nM
CC(=O)NC(C)C#Cc1cnc(Oc2ccc(OC3CCCC3)cc2)s1 CHEMBL221262 IC50 470.0 nM
CC(C)n1ncc2c1C(=O)NC1(CCN(C(=O)C3=CC4N=C(N)NC4C=C3)CC1)C2 CHEMBL3699861 IC50 487.0 nM
CCCOc1ccc(N2CCN(c3noc(CC)n3)C(C(F)(F)F)C2)c(C)c1 CHEMBL3110079 IC50 492.0 nM
CC(C)(C)n1cc2c(n1)C(=O)NC1(CCN(C(=O)c3ccc4ccnc(NC5COC5)c4c3)CC1)C2 CHEMBL3699928 IC50 494.0 nM
Cc1n[nH]c2c(C)cc(C(=O)N3CCC4(CC3)Cc3cn(C(C)(C)C)nc3C(=O)N4C)cc12 CHEMBL2419610 IC50 500.0 nM
CC(C)(C)n1cc2c(n1)C(=O)NC1(CCN(C(=O)c3ccc4ccc(NC5COC5)nc4c3)CC1)C2 CHEMBL3699919 IC50 507.0 nM
CCNC(=O)Nc1sc2ccccc2c1C(=O)N1CCC(N2CCCC3(CCN(C)C3=O)C2)CC1 CHEMBL2030566 IC50 510.0 nM
CNC1=NC2C=C(C(=O)N3CCC4(CC3)Cc3cnn(C(C)C)c3C(=O)N4)C=NC2N1 CHEMBL3699859 IC50 523.0 nM
O=C(c1ccc2[nH]c(-c3ccccc3)nc2c1)N1CCC2(CC1)CC(=O)N(c1ccc(C(F)(F)F)cc1)C2 CHEMBL4245805 IC50 527.0 nM
CC(=O)NC(C)c1ccc(-c2ccc(Oc3ccc(OC(C)C)cc3)cc2C)c(C)c1 CHEMBL584907 IC50 592.0 nM
CC(C)n1ncc2c1C(=O)NC1(CCN(C(=O)c3ccc4ncccc4c3)CC1)C2 CHEMBL3699847 IC50 619.0 nM
CC(CCc1ccc(Oc2ccc(OC(C)C)nc2)cc1)NC(=O)C1CC1 CHEMBL1630700 IC50 620.0 nM
CC(C)n1ncc2c1C(=O)NC1(CCN(C(=O)c3ccc4ccncc4c3)CC1)C2 CHEMBL3699849 IC50 621.0 nM
CC(C)n1ncc2c1C(=O)NC1(CCN(C(=O)c3cnc4c(c3)=CCN=4)CC1)C2 CHEMBL3699835 IC50 648.0 nM
CC(=O)NC(C)C#Cc1cnc(Oc2cccc(Oc3ccccc3)c2)s1 CHEMBL375380 IC50 650.0 nM
CCNC(=O)Nc1sc2ccccc2c1C(=O)N1CCC(N2CCCC3(CCNC3=O)C2)CC1 CHEMBL2030565 IC50 650.0 nM
CC1=NC2C=C(C(=O)N3CCC4(CC3)Cc3cn(C(C)C)nc3C(=O)N4)C=CC2N1 CHEMBL3699866 IC50 656.0 nM
CC(C)n1ncc2c1C(=O)NC1(CCN(C(=O)c3cc4ncccc4[nH]3)CC1)C2 CHEMBL3699844 IC50 657.0 nM
COC(=O)NC(C)C#Cc1cnc(Oc2ccc(OCC3CC3)cc2)s1 CHEMBL222464 IC50 670.0 nM
CC1C(=O)c2nn(C(C)(C)C)cc2OC12CCN(C(=O)c1ccc3[nH]ncc3c1)CC2 CHEMBL3359259 IC50 674.0 nM
CCCOc1ccc(N2CCN(c3noc(CC)n3)[C@@H](C)C2)c(Cl)c1 CHEMBL3110085 IC50 688.0 nM
CC(C)n1ncc2c1C(=O)NC1(CCN(C(=O)c3ccc4cccnc4c3)CC1)C2 CHEMBL3699850 IC50 688.0 nM
CCN(CC)C(=O)C1CCCN(C2CCN(C(=O)c3c4ccccc4cc4ccccc34)CC2)C1 CHEMBL1910387 IC50 720.0 nM
CCOc1ccc(N2CCN(c3noc([C@@H](C)NC(C)=O)n3)[C@@H](C)C2)c(C)c1 CHEMBL3110093 IC50 724.0 nM
CC(=O)NC(C)CCc1ccc(Oc2ccc(OCc3ccccc3)cn2)cc1 CHEMBL1630709 IC50 750.0 nM
CC(=O)N[C@@H](C)/C=C/c1cnc(Oc2ccc(OCC3CC3)cc2Cl)cn1 CHEMBL4226182 IC50 750.0 nM
CCCOc1ccc(Oc2ccc(-c3ccc(C(C)NC(=O)COC)cc3)cc2)cc1 CHEMBL566860 IC50 753.0 nM
CC(=O)NC(C)C#Cc1cnc(Oc2ccc(OCC3CCOC3)cc2)s1 CHEMBL219665 IC50 760.0 nM
CC(C)(C)OC(=O)NC[C@H]1CC[C@H](CNC(=O)c2cc(N3CCC(CCN)CC3)nc3ccccc23)CC1 CHEMBL1818297 IC50 780.0 nM
CC(=O)NC(C)c1ccc(OCc2ccc(Oc3cccc(OCC4CC4)c3)nc2)cc1 CHEMBL4753303 IC50 790.0 nM
CCOc1ccc(N2CCN(c3noc(C(C)(C)NC(C)=O)n3)[C@@H](C)C2)c(C)c1 CHEMBL3110075 IC50 811.0 nM
CC(=O)N[C@@H](C)/C=C/c1ccc(Oc2ccc3sc(C(C)C)nc3c2Cl)nc1 CHEMBL4228805 IC50 858.0 nM
CC(=O)N[C@@H](C)CCc1ccc(Oc2ccc(OCc3ccccc3)cn2)cc1 CHEMBL1630710 IC50 920.0 nM
CC(=O)NC(C)C#Cc1cnc(Oc2ccc(OCC3CC3)cc2)s1 CHEMBL376717 IC50 940.0 nM
CC(=O)N[C@@H](C)/C=C/c1ccc(Oc2ccc(OCC3CC3)cc2Cl)nc1 CHEMBL4224858 IC50 964.0 nM
CC(C#Cc1cnc(Oc2ccc(Oc3ccccc3)cc2)s1)N(O)C(N)=O CHEMBL378186 IC50 1000.0 nM
CC(C)(C)OC(=O)NC[C@H]1CC[C@H](CNC(=O)c2cc(N3CCC(CCN4CC(O)C4)CC3)nc3ccccc23)CC1 CHEMBL1818300 IC50 1000.0 nM
CN(C)CCC1CCN(c2cc(C(=O)NC[C@H]3CC[C@H](CNC(=O)OCC(C)(C)C)CC3)c3ccccc3n2)CC1 CHEMBL1818303 IC50 1000.0 nM
CCN(CC)C(=O)c1cccc(N2CCN(C(=O)c3c4ccccc4cc4ccccc34)CC2)c1 CHEMBL1910388 IC50 1000.0 nM
CC(C)(C)n1cc2c(n1)C(=O)CC1(CCN(C(=O)c3ccnc(-c4ccc(C(=O)O)cc4)c3)CC1)O2 CHEMBL4799861 pIC50 1000.0 nM