COc1cc2c(cc1OC)C(=O)/C(=C/c1ccc(OCCCCN[N+]3(C)CCN(c4ccc(/C=C5\Cc6cc(OC)c(OC)cc6C5=O)cc4)CC3)cc1)C2 CHEMBL4780352 IC50 0.0 nM
O=C(CCCCNc1c2c(nc3ccccc13)CCCC2)NCCc1c[nH]c2ccccc12 CHEMBL4443426 IC50 5e-06 nM
O=C(CCCCCNc1c2c(nc3ccccc13)CCCC2)NCCc1c[nH]c2ccccc12 CHEMBL199861 IC50 5e-06 nM
O=C(CCCCCCNc1c2c(nc3ccccc13)CCCC2)NCCc1c[nH]c2ccccc12 CHEMBL199670 IC50 5e-06 nM
O=C(CCCCCCCNc1c2c(nc3ccccc13)CCCC2)NCCc1c[nH]c2ccccc12 CHEMBL4556734 IC50 5e-06 nM
O=C(CCCCCNc1c2c(nc3cc(Cl)ccc13)CCCC2)NCCc1c[nH]c2ccccc12 CHEMBL383663 IC50 5e-06 nM
O=C(CCCCCCNc1c2c(nc3cc(Cl)ccc13)CCCC2)NCCc1c[nH]c2ccccc12 CHEMBL381499 IC50 5e-06 nM
O=C(CCCCCNc1c2c(nc3c(Cl)cccc13)CCCC2)NCCc1c[nH]c2ccccc12 CHEMBL4448350 IC50 5e-06 nM
O=C(CCCCCNc1c2c(nc3cc(Cl)cc(Cl)c13)CCCC2)NCCc1c[nH]c2ccccc12 CHEMBL199538 IC50 5e-06 nM
O=C(CCCCCCNc1c2c(nc3cc(Cl)cc(Cl)c13)CCCC2)NCCc1c[nH]c2ccccc12 CHEMBL199585 IC50 5e-06 nM
O=C(CCCCCCCNc1c2c(nc3cc(Cl)cc(Cl)c13)CCCC2)NCCc1c[nH]c2ccccc12 CHEMBL4590945 IC50 5e-06 nM
O=C(CCCCCNc1c2c(nc3ccc(F)cc13)CCCC2)NCCc1c[nH]c2ccccc12 CHEMBL4543251 IC50 5e-06 nM
COc1ccc2[nH]cc(CCNC(=O)CCCCNc3c4c(nc5ccccc35)CCCC4)c2c1 CHEMBL4455677 IC50 5e-06 nM
COc1ccc2[nH]cc(CCNC(=O)CCCCCNc3c4c(nc5ccccc35)CCCC4)c2c1 CHEMBL199454 IC50 5e-06 nM
COc1ccc2[nH]cc(CCNC(=O)CCCCCCNc3c4c(nc5ccccc35)CCCC4)c2c1 CHEMBL382260 IC50 5e-06 nM
COc1ccc2[nH]cc(CCNC(=O)CCCCCCCNc3c4c(nc5ccccc35)CCCC4)c2c1 CHEMBL4532770 IC50 5e-06 nM
COc1ccc2[nH]cc(CCNC(=O)CCCCCNc3c4c(nc5cc(Cl)ccc35)CCCC4)c2c1 CHEMBL199748 IC50 5e-06 nM
COc1ccc2[nH]cc(CCNC(=O)CCCCCNc3c4c(nc5cccc(Cl)c35)CCCC4)c2c1 CHEMBL200008 IC50 5e-06 nM
COc1ccc2[nH]cc(CCNC(=O)CCCCCNc3c4c(nc5cc(Cl)cc(Cl)c35)CCCC4)c2c1 CHEMBL4468781 IC50 5e-06 nM
COc1ccc2[nH]cc(CCNC(=O)CCCCCCNc3c4c(nc5cc(Cl)cc(Cl)c35)CCCC4)c2c1 CHEMBL372202 IC50 5e-06 nM
O=C(CCCCCNc1c2c(nc3ccccc13)CCCC2)NCCc1c[nH]c2ccc(O)cc12 CHEMBL370807 IC50 5e-06 nM
O=C(CCCCCCCNc1c2c(nc3ccccc13)CCCC2)NCCc1c[nH]c2ccc(O)cc12 CHEMBL4579667 IC50 5e-06 nM
S=C(CCCCCNc1c2c(nc3ccccc13)CCCC2)NCCc1c[nH]c2ccccc12 CHEMBL4469239 IC50 5e-06 nM
S=C(CCCCCCCNc1c2c(nc3ccccc13)CCCC2)NCCc1c[nH]c2ccccc12 CHEMBL4467284 IC50 5e-06 nM
COc1cc2c(cc1OC)[C@@H](c1ccccc1)N(CCCCCCc1cnnn1CCNc1c3c(nc4ccccc14)CCCC3)CC2 CHEMBL3314093 Kd 3.3e-05 nM
COc1cc2c(cc1OC)[C@H](c1ccccc1)N(CCCCCCc1cnnn1CCNc1c3c(nc4ccccc14)CCCC3)CC2 CHEMBL3314092 Kd 3.6e-05 nM
Nc1ccc2c(c1)c(-c1ccccc1)[n+](CCCCCCc1cnnn1CCNc1c3c(nc4ccccc14)CCCC3)c1cc(N)ccc21 CHEMBL117651 Kd 7.7e-05 nM
O=C(CCCc1c[nH]c2ccccc12)NCCCCCNc1c2c(nc3cc(Cl)ccc13)CCCC2 CHEMBL225021 Ki 0.0017 nM
COc1ccc2c3c1O[C@H]1C[C@@H](O)C=C[C@@]31CCN(C)C2 CHEMBL659 MIC 0.003 nM
COc1ccc(C(C)NS(=O)(=O)NC(=O)OCc2ccccc2)cc1 CHEMBL3585776 Ki 0.0045 nM
COc1ccc(C(C)NS(N)(=O)=O)cc1OC CHEMBL3585782 Ki 0.0049 nM
COc1ccc(C(C)NS(=O)(=O)NC(=O)OCc2ccccc2)cc1OC CHEMBL3585777 Ki 0.0051 nM
COc1ccccc1C(C)NS(=O)(=O)NC(=O)OCc1ccccc1 CHEMBL3585775 Ki 0.0056 nM
COc1ccc(OC)c(C(C)NS(N)(=O)=O)c1 CHEMBL3585783 Ki 0.0056 nM
O=C(NCCCNc1c2c(nc3cc(Cl)ccc13)CCCC2)c1ccc2nc(-c3ccc(Cl)cc3)c3c(c2c1)NCCC3 CHEMBL3322232 IC50 0.006 nM
COc1ccc(C(C)NS(N)(=O)=O)cc1 CHEMBL3585781 Ki 0.0063 nM
O=C(NCCCCCNc1c2c(nc3ccccc13)CCCC2)c1c2ccccc2nc2ccccc12 CHEMBL4451843 IC50 0.0076 nM
O=C(CCCCCCNc1c2c(nc3cccc(Cl)c13)CCCC2)NCCc1c[nH]c2ccccc12 CHEMBL4589980 IC50 0.008 nM
COc1cccc(OC)c1C(C)NS(N)(=O)=O CHEMBL3585784 Ki 0.0081 nM
O=C(CCc1c[nH]c2ccccc12)NCCCCCCCNc1c2c(nc3cc(Cl)ccc13)CCCC2 CHEMBL225198 Ki 0.009 nM
COc1cccc(OC)c1C(C)NS(=O)(=O)NC(=O)OCc1ccccc1 CHEMBL3585779 Ki 0.0105 nM
COc1ccccc1C(=O)N1Cc2cc(NC(=O)c3cccc(Cl)c3)ccc2CC1=O CHEMBL4205425 IC50 0.01095 nM
CN(CCCCNc1c2c(nc3ccccc13)CCCC2)CCCNc1c2c(nc3ccccc13)CCCC2 CHEMBL489454 Ki 0.0118 nM
CC/C=C/C12C3CC4C5[C@@H](C)/C(=C6/OC(=O)C(C)=C6OC)O[C@]5(O3)C1CCN42 CHEMBL1082736 MIC 0.012 nM
O=C(Nc1ccc2c(c1)CN(C(=O)c1ccccc1)C(=O)C2)c1cccc(Cl)c1 CHEMBL4205954 IC50 0.01323 nM
Cc1cccc(C(=O)Nc2ccc3c(c2)CN(C(=O)c2cccc(C)c2)C(=O)C3)c1 CHEMBL4209803 IC50 0.01352 nM
O=C(CCc1c[nH]c2ccccc12)NCCCCCCNc1c2c(nc3cc(Cl)ccc13)CCCC2 CHEMBL225567 Ki 0.014 nM
O=C(Nc1ccc2c(c1)CN(C(=O)c1cccc(Cl)c1)C(=O)C2)c1cccc(Cl)c1 CHEMBL4217663 IC50 0.01415 nM
Cc1cccc(C(=O)N2Cc3cc(NC(=O)c4cccc(Cl)c4)ccc3CC2=O)c1 CHEMBL4210316 IC50 0.01441 nM
O=C(Cc1c[nH]c2ccccc12)NCCCCCCCNc1c2c(nc3cc(Cl)ccc13)CCCC2 CHEMBL223443 Ki 0.015 nM
COc1ccccc1C(=O)Nc1ccc2c(c1)CN(C(=O)c1cccc(Cl)c1)C(=O)C2 CHEMBL4214430 IC50 0.01672 nM
COc1ccccc1C(=O)N1Cc2cc(NC(=O)c3ccccc3)ccc2CC1=O CHEMBL4213253 IC50 0.01893 nM
O=C(Cc1c[nH]c2ccc(Br)cc12)NCCCCCCCNc1c2c(nc3cc(Cl)ccc13)CCCC2 CHEMBL225326 Ki 0.02 nM
O=C(CCc1c[nH]c2ccccc12)NCCCCCCNc1c2c(nc3ccccc13)CCCC2 CHEMBL1083983 IC50 0.02 nM
Cc1cccc(C(=O)Nc2ccc3c(c2)CN(C(=O)c2cccc(Cl)c2)C(=O)C3)c1 CHEMBL4214707 IC50 0.02094 nM
COc1ccccc1C(=O)Nc1ccc2c(c1)CN(C(=O)c1ccccc1OC)C(=O)C2 CHEMBL4210041 IC50 0.02158 nM
CC[N+](CC)(CCCCCn1c(C)cc(=O)n(CCCCC[N+](CC)(CC)Cc2ccccc2)c1=O)Cc1ccccc1 CHEMBL5433692 Ki 0.022 nM
COc1ccc(OC)c(C(C)NS(=O)(=O)NC(=O)OCc2ccccc2)c1 CHEMBL3585778 Ki 0.0229 nM
COc1ccccc1C(=O)Nc1ccc2c(c1)CN(C(=O)c1cccc(C)c1)C(=O)C2 CHEMBL4205144 IC50 0.02592 nM
CCC1=CC2Cc3nc4cc(Cl)ccc4c(N)c3[C@@H](C1)C2 CHEMBL208599 Ki 0.026 nM
Cc1cccc(C(=O)N2Cc3cc(NC(=O)c4ccccc4)ccc3CC2=O)c1 CHEMBL4218191 IC50 0.02621 nM
COc1ccccc1C(C)NS(N)(=O)=O CHEMBL3585780 IC50 0.02685 nM
O=C(Nc1ccc2c(c1)CN(C(=O)c1cccc(Cl)c1)C(=O)C2)c1ccccc1 CHEMBL4208866 IC50 0.02836 nM
COc1ccccc1C(=O)Nc1ccc2c(c1)CN(C(=O)c1ccccc1)C(=O)C2 CHEMBL4209518 IC50 0.02938 nM
CC1=CC2Cc3nc4cc(Cl)ccc4c(N)c3C(C1)C2 CHEMBL536047 Ki 0.033 nM
COc1cc(O)c2c(=O)cc(C(=O)NCCCCCCCCCCNc3c4c(nc5cc(Cl)ccc35)CCCC4)oc2c1 CHEMBL2019048 IC50 0.035 nM
CN(C)C(=O)Oc1cccc([N+](C)(C)C)c1 CHEMBL54126 IC50 0.043 nM
O=C(CCc1c[nH]c2ccccc12)NCCCCCCCNc1c2c(nc3ccccc13)CCCC2 CHEMBL1083984 IC50 0.06 nM
O=C(NCCCCCCCCCCNc1c2c(nc3cc(Cl)ccc13)CCCC2)c1cc(=O)c2c(O)cc(O)cc2o1 CHEMBL2019049 IC50 0.065 nM
COc1cc(/C=C/c2nnc(-c3ccc(C(F)(F)F)cc3)o2)ccc1O CHEMBL5190569 IC50 0.068 nM
Clc1ccc2c(NCCCCCCCNc3c4c(nc5cc(Cl)ccc35)CCCC4)c3c(nc2c1)CCCC3 CHEMBL307004 IC50 0.07 nM
CC[N+](CC)(CCCCCn1c(C)cc(=O)n(CCCCC[N+](CC)(CC)Cc2ccccc2[N+](=O)[O-])c1=O)Cc1ccccc1[N+](=O)[O-] CHEMBL3621322 Ki 0.08 nM
C=CCN(CCCCNc1c2c(nc3ccccc13)CCCC2)CCCNc1c2c(nc3ccccc13)CCCC2 CHEMBL507174 Ki 0.0847 nM
O=C(NCCCCCCCCCCNc1c2c(nc3cc(Cl)ccc13)CCCC2)c1cc(=O)c2cc(O)c(O)cc2o1 CHEMBL2019053 IC50 0.09 nM
COc1cc(/C=C/c2nnc(-c3ccc(OC(F)(F)F)cc3)o2)ccc1O CHEMBL5197518 IC50 0.092 nM
COc1ccc2oc(C(=O)NCCCCCCCCCCNc3c4c(nc5cc(Cl)ccc35)CCCC4)cc(=O)c2c1 CHEMBL2019035 IC50 0.1 nM
CC[N+](CC)(CCCCCn1c(=O)cc(C)n(CCCCCCn2c(C)cc(=O)n(C)c2=O)c1=O)Cc1ccccc1[N+](=O)[O-] CHEMBL5417346 IC50 0.1 nM
COc1ccccc1CN(C)CCCCCC(=O)N(C)CCCCCCCCN(C)C(=O)CCCCCN(C)Cc1ccccc1OC CHEMBL11805 Ki 0.104 nM
OCCN(CCCCNc1c2c(nc3ccccc13)CCCC2)CCCNc1c2c(nc3ccccc13)CCCC2 CHEMBL499224 Ki 0.1191 nM
COc1cc2c(cc1O)CCC(C)(CCNCCCCCCCCNc1c3c(nc4cc(Cl)ccc14)CCCC3)O2 CHEMBL4751100 IC50 0.12 nM
c1ccc2c(NCCCN3CCN(CCCNc4c5c(nc6ccccc46)CCCC5)CC3)c3c(nc2c1)CCCC3 CHEMBL445454 Ki 0.1359 nM
COc1cc2c(cc1OC)C(=O)/C(=C/c1cc[n+](Cc3ccc(F)cc3)cc1)OC2 CHEMBL5187881 IC50 0.15 nM
CC[N+](CC)(CCCCCn1c(=O)cc(C)n(CCCCCCn2c(C)cc(=O)n(C)c2=O)c1=O)Cc1ccccc1C(F)(F)F CHEMBL5419243 Ki 0.15 nM
CCN(CCCCNc1c2c(nc3ccccc13)CCCC2)CCCNc1c2c(nc3ccccc13)CCCC2 CHEMBL490060 Ki 0.162 nM
COc1cc(/C=C/c2nnc(-c3ccc(F)cc3F)o2)ccc1O CHEMBL5286535 IC50 0.19 nM
c1ccc2c(NCCCCCCCNc3c4c(nc5ccccc35)CCCC4)c3c(nc2c1)CCCC3 CHEMBL32823 IC50 0.2 nM
COc1cc2oc(C(=O)NCCCCCCCCCCNc3c4c(nc5cc(Cl)ccc35)CCCC4)cc(=O)c2cc1OC CHEMBL2019041 IC50 0.2 nM
COc1cccc2c1CCCC2NS(=O)(=O)NC(=O)OCc1ccccc1 CHEMBL5219841 IC50 0.209 nM
COc1cc(/C=C/c2nnc(-c3ccc(Cl)cc3Cl)o2)ccc1O CHEMBL5272625 IC50 0.22 nM
CC(=O)N(CCCCNc1c2c(nc3ccccc13)CCCC2)CCCNc1c2c(nc3ccccc13)CCCC2 CHEMBL451277 Ki 0.223 nM
O=C(CCCC[C@@H]1CCSS1)NCCCNc1c2c(nc3cc(Cl)ccc13)CCCC2 CHEMBL1912059 IC50 0.23 nM
Nc1cccc2c(NCCCCCCCCNc3c4c(nc5ccccc35)CCCC4)c3c(nc12)CCCC3 CHEMBL3099497 Ki 0.23 nM
COc1cc2oc(=O)c(OCCCCOc3cc(O)cc(N(C)C)c3)c(C)c2cc1OC CHEMBL1940738 IC50 0.236 nM
CC[C@H](O)[C@@H]1CC[C@@H]2O[C@@]34CCC[N+]1([O-])[C@@H]2[C@H]3[C@H](C)/C(=C1/OC(=O)C(C)=C1OC)O4 CHEMBL1642207 MIC 0.24 nM
O=C(CCCCC1CCSS1)NCCCNc1c2c(nc3cc(Cl)ccc13)CCCC2 CHEMBL194823 IC50 0.25 nM
COc1cc2c(c(OC)c1)CC(NC(=O)OCc1ccccc1)C2 CHEMBL5219123 Ki 0.261 nM
COc1cccc2c1CCC(NC(=O)OCc1ccccc1)C2 CHEMBL5218804 Ki 0.264 nM
COc1cc2c(cc1OC)C(=O)C(CC1CCN(CCCNc3c4c(nc5cc(Cl)ccc35)CCCC4)CC1)C2 CHEMBL3216655 IC50 0.27 nM
COc1cc2c(cc1OC)C(=O)C(CC1CCN(CCCNc3c4c(nc5cc(Cl)ccc35)CCCC4)CC1)C2 CHEMBL1187434 IC50 0.27 nM
COc1cc2c(cc1O)CCC(C)(CCNCCCCCCCCCNc1c3c(nc4cc(Cl)ccc14)CCCC3)O2 CHEMBL4785201 IC50 0.27 nM
COc1cc(/C=C/c2nnc(-c3ccc(F)cc3)o2)ccc1O CHEMBL5269238 IC50 0.284 nM
CC1=C[C@@H]2Cc3nc4cc(Cl)ccc4c(NCCCN(C)CCCCNc4c5c(nc6cc(Cl)ccc46)CCCC5)c3[C@H](C1)C2 CHEMBL2113367 IC50 0.29 nM
CNC(=O)Oc1cccc(CN(C)CCCOc2ccc3c(=O)c4ccccc4oc3c2)c1 CHEMBL340427 IC50 0.3 nM
CN(CCCNc1c2c(nc3ccccc13)CCCC2)CCCNc1c2c(nc3ccccc13)CCCC2 CHEMBL338755 IC50 0.3 nM
Clc1ccc2c(NCCCCCCCCNc3c4c(nc5cc(Cl)ccc35)CCCC4)c3c(nc2c1)CCCC3 CHEMBL312310 IC50 0.3 nM
O=C(NCCCCCCCCCCNc1c2c(nc3cc(Cl)ccc13)CCCC2)c1cc(=O)c2ccccc2o1 CHEMBL2019032 IC50 0.3 nM
NC12CC3CC(F)(CC(C1)c1cc(NC(=O)CCCNc4c5c(nc6cc(Cl)ccc46)CCCC5)ccc13)C2 CHEMBL4471659 IC50 0.3 nM
CC1=CC2Cc3nc4cc(Cl)ccc4c(NCCCN(C)CCCNc4c5c(nc6cc(Cl)ccc46)CCCC5)c3C(C1)C2 CHEMBL2011495 IC50 0.31 nM
CN(CCC(=O)N1CCN(CCNc2c3c(nc4ccccc24)CCCC3)CC1)C1CCCCC1 CHEMBL2064464 Ki 0.318 nM
CNC(=O)Oc1cccc(CN(C)CCCCCCCOc2ccc3c(=O)c4ccccc4oc3c2)c1 CHEMBL543655 IC50 0.32 nM
CC1=CC2Cc3nc4cc(Cl)ccc4c(N)c3C(C1)C2 CHEMBL140476 IC50 0.32 nM
CC1=C[C@@H]2Cc3nc4cc(Cl)ccc4c(NCCCN(C)CCCCNc4c5c(nc6ccccc46)CCCC5)c3[C@H](C1)C2 CHEMBL2113368 IC50 0.32 nM
CNC(=O)Oc1cccc(CN(C)CCCCCCCOc2ccc3c(=O)c4ccccc4oc3c2)c1 CHEMBL189957 IC50 0.32 nM
CNCOc1cccc(CN(C)CCCCCCCOc2ccc3c(=O)c4ccccc4oc3c2)c1 CHEMBL2236393 IC50 0.32 nM
CCC1=CC2Cc3nc4cc(Cl)ccc4c(N)c3C(C1)C2 CHEMBL143812 Log IC50 0.3236 nM
O=C1Cc2cc3c(CCC4CCN(Cc5ccccc5)CC4)noc3cc2N1 CHEMBL329012 IC50 0.33 nM
O=C1Cc2cc3c(CCC4CCN(Cc5ccccc5)CC4)noc3cc2N1 CHEMBL359570 IC50 0.33 nM
CC1=CC2Cc3nc4cc(Cl)ccc4c(NCCCCCCCCNc4c5c(nc6ccccc46)CCCC5)c3C(C1)C2 CHEMBL534932 IC50 0.33 nM
CC1=CC2Cc3nc4cc(Cl)ccc4c(NCCCCCCCNc4c5c(nc6cc(Cl)ccc46)CCCC5)c3C(C1)C2 CHEMBL538573 IC50 0.33 nM
C[n+]1ccc2c(c1)c1ccccc1n2CCCCCCCCCn1c2ccccc2c2c[n+](C)ccc21 CHEMBL3605361 IC50 0.33 nM
COc1cc(/C=C/c2nnc(-c3ccc(Cl)cc3)o2)ccc1O CHEMBL5266033 IC50 0.334 nM
CC1=CC2Cc3nc4cc(Cl)ccc4c(NCCCCCCCNc4c5c(nc6ccccc46)CCCC5)c3C(C1)C2 CHEMBL557155 IC50 0.34 nM
COc1cc(OC)c2c(=O)cc(C(=O)NCCCCCCCCCCNc3c4c(nc5cc(Cl)ccc35)CCCC4)oc2c1 CHEMBL2019038 IC50 0.35 nM
CCN(CCCCCCNC1=CC(=O)C(NCCCCCCN(CC)[C@@H](C)c2ccccc2OC)=CC1=O)[C@H](C)c1ccccc1OC CHEMBL555300 IC50 0.36 nM
COc1cc2c(cc1OC)C(=O)C(Cc1cc[n+](Cc3ccccc3)cc1Br)C2 CHEMBL4165327 IC50 0.36 nM
CCN(CCCCCCN1C(=O)c2ccc3c4c(ccc(c24)C1=O)C(=O)N(CCCCCCN(CC)Cc1ccccc1OC)C3=O)Cc1ccccc1OC CHEMBL450553 IC50 0.37 nM
CC1=CC2Cc3nc4cc(Cl)ccc4c(NCCCCCCCCNc4c5c(nc6cc(Cl)ccc46)CCCC5)c3C(C1)C2 CHEMBL539599 IC50 0.4 nM
CC[N+](CC)(CCCCCn1c(=O)cc(C)n(CCCCCn2c(C)cc(=O)n(C)c2=O)c1=O)Cc1ccccc1[N+](=O)[O-] CHEMBL5440753 IC50 0.4 nM
CC1=CC2Cc3nc4cc(Cl)ccc4c(NCCCCCCCCC(=O)N4CCNC(=O)C4)c3C(C1)C2 CHEMBL4854913 IC50 0.41 nM
CC1=CC2Cc3nc4cc(Cl)ccc4c(NCCCN(C)CCCNc4c5c(nc6ccccc46)CCCC5)c3C(C1)C2 CHEMBL2011487 IC50 0.42 nM
CNC(=O)Oc1ccc2c(c1)[C@]1(C)CCN(C)[C@@H]1N2C CHEMBL94 IC50 0.43 nM
CC1=C[C@@H]2Cc3nc4cc(Cl)ccc4c(N)c3[C@H](C1)C2 CHEMBL1994202 IC50 0.43 nM
CC1=C[C@@H]2Cc3nc4cc(Cl)ccc4c(N)c3[C@H](C1)C2 CHEMBL1161905 IC50 0.43 nM
Nc1c2c(nc3cc(Cl)ccc13)C[C@H]1C=C(CCCCn3cc(CO)nn3)C[C@H]2C1 CHEMBL4280612 IC50 0.43 nM
COc1cc2c(cc1O)CCC(C)(CCNCCCCCCCNc1c3c(nc4cc(Cl)ccc14)CCCC3)O2 CHEMBL4796461 IC50 0.44 nM
CC1=CC2Cc3nc4cc(Cl)ccc4c(NCCCCCCNc4c5c(nc6cc(Cl)ccc46)CCCC5)c3C(C1)C2 CHEMBL555214 IC50 0.45 nM
COc1cccc2c1CCC(NS(=O)(=O)N(C)C)C2 CHEMBL3785269 Ki 0.45 nM
COc1ccc2cc3[n+](cc2c1OCc1ccc(C(F)(F)F)cc1)CCc1cc2c(cc1-3)OCO2 CHEMBL4752175 Ki 0.456 nM
O=C(CCCC[C@H]1CCSS1)NCCCNc1c2c(nc3cc(Cl)ccc13)CCCC2 CHEMBL1912058 IC50 0.471 nM
CN1C(=O)Cc2cc3onc(CCC4CCN(Cc5ccccc5)CC4)c3cc21 CHEMBL426441 Log Ki 0.4786 nM
CN1C(=O)Cc2cc3c(CCC4CCN(Cc5ccccc5)CC4)noc3cc21 CHEMBL1179697 pIC50 0.4786 nM
CN1C(=O)Cc2cc3c(CCC4CCN(Cc5ccccc5)CC4)noc3cc21 CHEMBL94546 IC50 0.48 nM
O=C1CNc2cc3onc(CCC4CCN(Cc5ccccc5)CC4)c3cc2C1 CHEMBL1083069 IC50 0.48 nM
O=C(CCC1CCN(Cc2ccc(O)cc2)CC1)c1cc2c3c(ccn3C(=O)CC2)c1 CHEMBL1651249 pIC50 0.4898 nM
CC1=CC2Cc3nc4cc(Cl)ccc4c(NCCCCCCNc4c5c(nc6ccccc46)CCCC5)c3C(C1)C2 CHEMBL555666 IC50 0.5 nM
CCN(CCCCCCNC1=CC(=O)C(NCCCCCCN(CC)[C@H](C)c2ccccc2OC)=CC1=O)[C@H](C)c1ccccc1OC CHEMBL540178 IC50 0.5 nM
O=C(CCc1c[nH]c2ccccc12)NCCCCCCCCNc1c2c(nc3cc(Cl)ccc13)CCCC2 CHEMBL389192 IC50 0.5 nM
O=C(CCCc1c[nH]c2ccccc12)NCCCCCCNc1c2c(nc3cc(Cl)ccc13)CCCC2 CHEMBL427082 IC50 0.5 nM
Cc1ccc2ccc(CNCCCCCCCCNc3c4c(nc5ccccc35)CCCC4)c(O)c2n1 CHEMBL3215816 IC50 0.5 nM
C[n+]1ccc2c3ccccc3n(CCc3ccccc3)c2c1 CHEMBL5280980 IC50 0.5 nM
CC[N+](CC)(CCCCCn1c(=O)cc(C)n(CCCCCn2c(C)cc(=O)n(C)c2=O)c1=O)Cc1ccccc1C(F)(F)F CHEMBL5426103 IC50 0.5 nM
O=C(Nc1ccc2c(c1)CN(C(=O)c1ccccc1)C(=O)C2)c1ccccc1 CHEMBL4213792 IC50 0.51 nM
CNC(=O)Oc1cccc(CN(C)CCCCCCCOc2ccc3c(c2)O/C(=C\c2cc(O)c(O)c(O)c2)C3=O)c1 CHEMBL1085932 IC50 0.52 nM
CNC(=O)Oc1cccc(CN(C)CCCCCCOc2ccc3c(c2)O/C(=C\c2cc(OC)c(OC)c(OC)c2)C3=O)c1 CHEMBL5220283 IC50 0.52 nM
CNC(=O)Oc1cccc(CN(C)CCCCCCCOc2cccc(-c3cc(=O)c4ccccc4o3)c2)c1 CHEMBL5219771 IC50 0.52 nM
C/C=C1\[C@H]2C=C(C)C[C@@]1(N)c1ccc(=O)[nH]c1C2 CHEMBL1255901 IC50 0.54 nM
CCN(CCCOc1ccc2c(=O)c3ccccc3oc2c1)Cc1cccc(OC(=O)NC)c1 CHEMBL128202 IC50 0.56 nM
O=C1CCc2cc3c(CCC4CCN(Cc5ccccc5)CC4)noc3cc2N1 CHEMBL329231 IC50 0.57 nM
N#Cc1ccc2[nH]cc(CCCCN3CCN(c4ccc(C(=O)CCC5CCN(Cc6ccccc6)CC5)cc4)CC3)c2c1 CHEMBL5082250 IC50 0.58 nM
Fc1ccc2c(NCCCCCCCNc3c4c(nc5cc(F)ccc35)CCCC4)c3c(nc2c1)CCCC3 CHEMBL74927 IC50 0.6 nM
Clc1ccc2c(NCCCCCCNc3c4c(nc5cc(Cl)ccc35)CCCC4)c3c(nc2c1)CCCC3 CHEMBL73160 IC50 0.6 nM
C[n+]1ccc2c3ccccc3n(CCCCCCCCCn3c4ccccc4c4cc[n+](C)cc43)c2c1 CHEMBL1198953 IC50 0.6 nM
CC[N+](CC)(CCCCCn1c(=O)cc(C)n(CCCCn2c(C)cc(=O)n(C)c2=O)c1=O)Cc1ccccc1[N+](=O)[O-] CHEMBL5434553 IC50 0.6 nM
CC1=CC2Cc3nc4cc(Cl)ccc4c(NCCCCCCCCC(=O)NCc4cc[nH]c(=O)c4)c3C(C1)C2 CHEMBL4848527 IC50 0.63 nM
COc1cc2c(cc1OC)C(=O)C(CC1CCN(CCNc3c4c(nc5cc(Cl)ccc35)CCCC4)CC1)C2 CHEMBL3216422 IC50 0.67 nM
COc1ccc2c(c1)CCC(NC(=O)N(C)C)C2 CHEMBL3786516 Ki 0.67 nM
COc1cc(CNC(=O)CCCCCCNc2c3c(nc4cc(Cl)ccc24)CC2C=C(C)CC3C2)ccc1O CHEMBL4754487 Ki 0.68 nM
CNC(=O)Oc1cccc(CN(CCCOc2ccc3c(=O)c4ccccc4oc3c2)C(C)C)c1 CHEMBL131579 IC50 0.7 nM
Fc1ccc2c(NCCCCCCCCNc3c4c(nc5cc(F)ccc35)CCCC4)c3c(nc2c1)CCCC3 CHEMBL312761 IC50 0.7 nM
N#Cc1ccc2[nH]cc(CCC(=O)NCCCCCCNc3c4c(nc5cc(Cl)ccc35)CCCC4)c2c1 CHEMBL223170 IC50 0.7 nM
O=C(CCOCCc1c[nH]c2ccccc12)NCCCCCCNc1c2c(nc3cc(Cl)ccc13)CCCC2 CHEMBL1084544 IC50 0.7 nM
C[N+](C)(CCNC(=O)C(=O)NCC[N+](C)(C)Cc1ccccc1Cl)Cc1ccccc1Cl CHEMBL1669479 IC50 0.7 nM
O=C1C(NCCNc2c3c(nc4cc(Cl)ccc24)CCCC3)=CC(=O)c2c(O)cccc21 CHEMBL3356536 IC50 0.72 nM
c1ccc2oc(CNCCCCCCCNc3c4c(nc5ccccc35)CCCC4)cc2c1 CHEMBL3752467 Ki 0.72 nM
CN(C)S(=O)(=O)NC1CCc2ccc(O)cc2C1 CHEMBL3786719 Ki 0.72 nM
O=C(CCCCCNc1c2c(nc3cc(Cl)ccc13)CCCC2)NCCc1cc2ccccc2[nH]1 CHEMBL4448188 IC50 0.73 nM
CNC(=O)Oc1cccc(CN(C)CCCCCCCOc2ccc(-c3cc(=O)c4ccccc4o3)cc2)c1 CHEMBL5218632 IC50 0.73 nM
CC1=CC2Cc3nc4cc(Cl)ccc4c(NCCCCCCNc4c5c(nc6cc(Cl)ccc46)CCCC5)c3C(C1)C2 CHEMBL2011491 IC50 0.74 nM
CC1=C[C@@H]2Cc3nc4cc(Cl)ccc4c(N)c3[C@H](C1)C2 CHEMBL2007996 IC50 0.74 nM
c1cc(CCNc2c3c(nc4ccccc24)CCCC3)nc(CCNc2c3c(nc4ccccc24)CCCC3)c1 CHEMBL521935 Ki 0.768 nM
COc1ccc2oc(C(=O)NCCCCCCCCCCNc3c4c(nc5ccccc35)CCCC4)cc(=O)c2c1 CHEMBL2019034 IC50 0.775 nM
O=[N+]([O-])c1cccc2c(NCCCCCCCCNc3c4c(nc5ccccc35)CCCC4)c3c(nc12)CCCC3 CHEMBL3099496 Ki 0.78 nM
O=C(NCCCCNc1c2c(nc3ccccc13)CCCC2)c1ccc(F)cc1 CHEMBL1814731 IC50 0.784 nM
c1ccc(CN2CCC(CCc3noc4cc(N5CCOCC5)ccc34)CC2)cc1 CHEMBL93936 Log Ki 0.7943 nM
c1ccc(CN2CCC(CCc3noc4cc(C5CCCCC5)ccc34)CC2)cc1 CHEMBL1651247 pIC50 0.7943 nM
CO[P@]1(=O)OC[C@H]2COC(=O)C2=C(C)O1 CHEMBL603622 IC50 0.8 nM
NC(=O)c1ccc2c(CCC3CCN(Cc4ccccc4)CC3)noc2c1 CHEMBL92663 IC50 0.8 nM
COc1cc2c(cc1OC)C(=O)/C(=C/c1cc[n+](Cc3ccccc3F)cc1)C2 CHEMBL4076580 IC50 0.8 nM
O=C(Nc1ccc(-c2cn(CCNc3c4c(nc5ccccc35)CCCC4)nn2)cn1)Nc1cccc2c1C1CCCCN1C2=O CHEMBL4583650 IC50 0.8 nM
NC(=O)c1sc(-c2ccnc(NC(=O)CNCCNc3c4c(nc5ccccc35)CCCC4)c2)nc1OCC1CC1 CHEMBL4753347 IC50 0.8 nM
O=C(COc1ccc(Cl)cc1[N+](=O)[O-])NCCN1CCN(Cc2ccccc2)CC1 CHEMBL5185868 IC50 0.8 nM
O=C(NCCCNc1c2c(nc3ccccc13)CCCC2)c1ccc(F)cc1 CHEMBL1814730 IC50 0.809 nM
c1ccc2c(NCCCCCCCNc3c4c(nc5ccccc35)CCCC4)c3c(nc2c1)CCCC3 CHEMBL3752685 IC50 0.81 nM
O=C(NCCNc1c2c(nc3ccccc13)CCCC2)c1ccc(F)cc1 CHEMBL1814729 IC50 0.815 nM
CN1CCC(CC/C=C2\Cc3ccccc3C2=O)CC1 CHEMBL155945 IC50 0.82 nM
CCC1=CC2Cc3nc4ccccc4c(NCCCCCCCCNc4c5c(nc6ccccc46)CCCC5)c3C(C1)C2 CHEMBL535812 IC50 0.82 nM
CNC(=O)Oc1cccc(CN(C)CCCCCOc2ccc3c(=O)c4ccccc4oc3c2)c1 CHEMBL337999 IC50 0.82 nM
CCN(CCCCCOc1ccc2c(=O)c3ccccc3oc2c1)Cc1cccc(OC(=O)NC)c1 CHEMBL2236394 IC50 0.82 nM
COc1ccc2c(c1)CC(NS(=O)(=O)N(C)C)CC2 CHEMBL3786448 Ki 0.83 nM
O=C(CCCCCNc1c2c(nc3cccc(Cl)c13)CCCC2)NCCc1c[nH]c2ccccc12 CHEMBL202661 IC50 0.87 nM
COc1cc2c(cc1OC)C(=O)C(CC1CCN(CCCNc3c4c(nc5ccccc35)CCCC4)CC1)C2 CHEMBL3216886 IC50 0.88 nM
CC1=CC2Cc3nc4cc(Cl)ccc4c(NCCCCCCNc4c5c(nc6ccccc46)CCCC5)c3C(C1)C2 CHEMBL2011483 IC50 0.89 nM
CN1CCC(CCN2C(=O)c3ccccc3C2=O)CC1 CHEMBL345847 IC50 0.9 nM
Fc1ccc2c(NCCCCCCNc3c4c(nc5cc(F)ccc35)CCCC4)c3c(nc2c1)CCCC3 CHEMBL74940 IC50 0.9 nM
O=C(CCN1CCC2c3ccccc3NC2C1)Oc1ccc(/C=C2\CCn3c2nc2ccccc2c3=O)cc1 CHEMBL4755968 IC50 0.93 nM
O=C1Cc2cc3onc(CCC4CCN(Cc5ccccc5)CC4)c3cc2N1 CHEMBL328468 IC50 0.95 nM
Cn1c2nc3ccccc3c-2c(NCCCCCCCCNc2c3c(nc4ccccc24)CCCC3)c2ccccc21 CHEMBL4294640 IC50 0.95 nM
COc1cccc2c1CC[C@H](NC(=O)N(C)C)C2 CHEMBL3786651 Ki 0.98 nM
COc1ccc(-c2cc3c(c(=O)o2)C[C@]2(O)[C@@]4(C)C(=O)C=CC(C)(C)[C@]4(O)CC[C@@]2(C)O3)cc1OC CHEMBL283509 IC50 1.0 nM
Cc1cccc(F)c1 CHEMBL345698 -Log IC50 1.0 nM
O=C(O)CCCC[C@@H]1CCSS1 CHEMBL134342 IC50 1.0 nM
Oc1c(CNCCCCCCCCCNc2c3c(nc4ccccc24)CCCC3)cc(Cl)c2cccnc12 CHEMBL3216469 IC50 1.0 nM
c1ccc2c(c1)ccc[n+]2CCCCCCCCCC[n+]1cccc2ccccc21 CHEMBL225577 IC50 1.0 nM
COc1cc(O)c2c(=O)cc(C(=O)NCCCCCCCCCCNc3c4c(nc5ccccc35)CCCC4)oc2c1 CHEMBL2019046 IC50 1.0 nM
O=C(NCCCCCCCCCCNc1c2c(nc3cc(Cl)ccc13)CCCC2)c1cc(=O)c2cc(O)ccc2o1 CHEMBL2019044 IC50 1.0 nM
C#CCNc1nc(NCCCCC2CCN(Cc3ccccc3)CC2)c(C#N)cc1C#N CHEMBL4225157 IC50 1.0 nM
COc1ccc([C@H](O)[C@H](N)C(=O)O)cc1OC CHEMBL4647106 IC50 1.0 nM
O=C(Nc1cncc(OCC2CCN(Cc3ccc(F)cc3)CC2)c1)c1ccnc(NC(=O)C2CC2)c1 CHEMBL4873612 IC50 1.0 nM
CC[N+](CC)(CCCCCn1c(=O)cc(C)n(CCCCn2c(C)cc(=O)n(C)c2=O)c1=O)Cc1ccccc1C(F)(F)F CHEMBL5417632 IC50 1.0 nM
Clc1ccc2c(NCCCCCCCNc3c4c(nc5ccccc35)-c3ccccc3C4)c3c(nc2c1)CCCC3 CHEMBL1819176 Ki 1.01 nM
COc1ccc2c(c1)CCC(NS(=O)(=O)N(C)C)C2 CHEMBL3787223 Ki 1.05 nM
COc1cc2c(cc1OC)CC(CC1CCN(CCCNc3c4c(nc5cc(Cl)ccc35)CCCC4)CC1)C2 CHEMBL3217103 IC50 1.06 nM
COc1ccc2c(c1)C[C@@H](NC(=O)N(C)C)CC2 CHEMBL3787502 Ki 1.06 nM
COc1cc(CNC(=O)Cc2cn(CCCCC3=CC4Cc5nc6cc(Cl)ccc6c(N)c5C(C3)C4)nn2)ccc1O CHEMBL4744528 IC50 1.06 nM
CC1=CC2Cc3nc4cc(Cl)ccc4c(NCCCCCNC(=O)c4cc(O)c5c(c4)C(=O)c4cccc(O)c4C5=O)c3C(C1)C2 CHEMBL3233826 IC50 1.07 nM
O=C(CCCCN1CCC2c3ccccc3NC2C1)Oc1ccc(/C=C2\CCn3c2nc2ccccc2c3=O)cc1 CHEMBL4791642 IC50 1.08 nM
O=C(CCC1CCN(Cc2ccccc2O)CC1)c1cc2c3c(ccn3C(=O)CC2)c1 CHEMBL1651139 pIC50 1.096 nM
CNC(=O)Oc1cccc(CN(C)CCCOc2ccc3c(=O)c4cccnc4oc3c2)c1 CHEMBL131827 IC50 1.1 nM
CC(=O)NCCc1c[nH]c2ccc(OC(=O)NCCCCCCCCCCNc3c4c(nc5ccccc35)CCCC4)cc12 CHEMBL3642052 IC50 1.18 nM
O=C(Nc1ccc2c(c1)C(=O)N(CCC1CCN(Cc3ccccc3)CC1)C2=O)c1ccccc1 CHEMBL138107 IC50 1.2 nM
CNC(=O)c1sc(-c2ccnc(NC(=O)CNCCNc3c4c(nc5ccccc35)CCCC4)c2)nc1OCC1CC1 CHEMBL4789145 IC50 1.2 nM
CNC(=O)Oc1cccc(CN(C)CCCCCCCOc2ccc(-c3cc4ccccc4oc3=O)cc2)c1 CHEMBL2047525 IC50 1.2 nM
CN(C)S(=O)(=O)N[C@H]1CCc2cc(O)ccc2C1 CHEMBL3786442 Ki 1.22 nM
COC1=C(C)C(=O)O/C1=C1\O[C@@]23O[C@H]4C[C@@H]([C@H]2[C@@H]1C)N1CC[C@H]3[C@@]41/C=C/C(C)O CHEMBL2068680 MIC 1.25 nM
Cn1c2nc3ccccc3c-2c(NCCCCCCNc2c3c(nc4ccccc24)CCCC3)c2ccccc21 CHEMBL4284047 IC50 1.25 nM
COc1cc(CNC(=O)CCCCCCCCNc2c3c(nc4cc(Cl)ccc24)CC2C=C(C)CC3C2)ccn1 CHEMBL4872514 IC50 1.25 nM
CCOc1ccc(Cc2nc3cc(C(=O)N(CC)CC)ccc3n2CCNc2c3c(nc4ccccc24)CCCC3)cc1 CHEMBL4458217 pIC50 1.259 nM
CCN(CC)c1cc(/C=C2/OC(=O)c3cc(OC)c(OC)cc32)ccc1O CHEMBL4778167 IC50 1.28 nM
O=C(CCC1CCN(Cc2cccc(F)c2)CC1)c1cc2c3c(ccn3C(=O)CC2)c1 CHEMBL1651132 pIC50 1.288 nM
c1cnc2nc3c(c(NCCCCCCCNc4c5c(nc6ncccc46)CCCC5)c2c1)CCCC3 CHEMBL76173 IC50 1.3 nM
O=S(=O)(c1ccccc1)n1ccc2c(N3CCN(CCCCCCCCNc4c5c(nc6ccccc46)CCCC5)CC3)cccc21 CHEMBL3883432 IC50 1.3 nM
O=C(CCCCNc1c2c(nc3cc(Cl)ccc13)CCCC2)NC12CC3CC(F)(CC(C1)c1ccccc13)C2 CHEMBL4462369 IC50 1.3 nM
COc1cc2c(cc1O)C(=O)C(C)C2 CHEMBL347667 -Log IC50 1.318 nM
CC1=CC2Cc3nc4cc(Cl)ccc4c(NCCCCCCCCNc4c5c(nc6cc(Cl)ccc46)CCCC5)c3C(C1)C2 CHEMBL2011496 IC50 1.32 nM
CC1=C[C@@H]2Cc3nc4cc(Cl)ccc4c(NCCCCCCCNc4c5c(nc6ccccc46)CCCC5)c3[C@H](C1)C2 CHEMBL3216777 IC50 1.33 nM
CN(C)C(=O)NC1CCc2cc(O)ccc2C1 CHEMBL3785391 Ki 1.33 nM
CNC(=O)Oc1cccc(CN(C)CCCCCCOc2ccc(C(=O)/C=C/c3cc(OC)c(OC)c(OC)c3)c(O)c2)c1 CHEMBL5218900 IC50 1.33 nM
CN(C)S(=O)(=O)NC1CCc2c(O)cccc2C1 CHEMBL3786873 Ki 1.34 nM
CCN(CCC(=O)N1CCN(CCNc2c3c(nc4ccccc24)CCCC3)CC1)C1CCCCC1 CHEMBL2064465 Ki 1.35 nM
COC1=C(C)C(=O)O/C1=C1\O[C@@]23CCC[N+]4([O-])CCC[C@H](O2)[C@H]4[C@H]3[C@@H]1C CHEMBL1641983 MIC 1.38 nM
CC1=CC2Cc3nc4cc(Cl)ccc4c(NCCCCCCCCNc4c5c(nc6ccccc46)CCCC5)c3C(C1)C2 CHEMBL2011488 IC50 1.38 nM
CCC1=CC2Cc3nc4cc(Cl)cc(Cl)c4c(N)c3C(C1)C2 CHEMBL357207 IC50 1.39 nM
CNC(=O)Oc1cccc(CN(C)CCCCCCOc2ccc3c(=O)c4ccccc4oc3c2)c1 CHEMBL124933 IC50 1.4 nM
c1ccc2c(NCCCCCCNc3c4c(nc5ccccc35)CCCC4)c3c(nc2c1)CCCC3 CHEMBL73800 IC50 1.4 nM
FC12CC3CC(NCCCCCNc4c5c(nc6cc(Cl)ccc46)CCCC5)(CC(C1)c1ccccc13)C2 CHEMBL4558495 IC50 1.4 nM
O=C(CCCNc1c2c(nc3cc(Cl)ccc13)CCCC2)NC12CC3CC(F)(CC(C1)c1ccccc13)C2 CHEMBL4438626 IC50 1.4 nM
CCN(CCCCCCn1c(=O)c(=O)n(CCCCCCN(CC)Cc2ccccc2OC)c2ccccc21)Cc1ccccc1OC CHEMBL452339 IC50 1.41 nM
CC(=O)NCCc1c[nH]c2ccc(OC(=O)NCCCCCCCCCCNc3c4c(nc5ccc(Cl)cc35)CCCC4)cc12 CHEMBL3642054 IC50 1.43 nM
CN(CCCCNc1c2c(nc3c(NC(=O)CNC(=O)CC[C@H](NC(=O)CNC(=O)OCc4ccccc4)C(=O)N[C@@H](Cc4ccccc4)C(=O)OCc4ccccc4)cccc13)CCCC2)CCCNc1c2c(nc3ccccc13)CCCC2 CHEMBL3099500 Ki 1.48 nM
CC1=CC2Cc3nc4ccccc4c(NCCCCCCCCCCNc4c5c(nc6cc(Cl)ccc46)CCCC5)c3C(C1)C2 CHEMBL3600555 IC50 1.48 nM
Nc1ccc2c(c1)c(-c1ccccc1)[n+](CCCNCCCNCCCNc1c3c(nc4ccccc14)CCCC3)c1cc(N)ccc21 CHEMBL179455 Ki 1.49 nM
Nc1ccc2c(c1)c(-c1ccccc1)[n+](CCCNCCCNCCCNc1c3c(nc4ccccc14)CCCC3)c1cc(N)ccc21 CHEMBL1085702 IC50 1.49 nM
CN1CCC(CCCC2Cc3ccccc3C2=O)CC1 CHEMBL263322 IC50 1.5 nM
COC1=C(C)C(=O)O/C1=C1\O[C@@]23O[C@H]4C[C@@H]([C@H]2[C@@H]1C)N1CC[C@H]3[C@@]41C CHEMBL2068678 MIC 1.5 nM
CCN(CCCCCCNC1=CC(=O)C(NCCCCCCN(CC)Cc2ccccc2OC)=CC1=O)Cc1ccccc1OC CHEMBL231160 IC50 1.5 nM
O=C(CCOCCc1c[nH]c2ccccc12)NCCCCCNc1c2c(nc3cc(Cl)ccc13)CCCC2 CHEMBL1086007 IC50 1.5 nM
CC1=C[C@@H]2Cc3nc4cc(Cl)ccc4c(NCCCCCCCNc4c5c(nc6cc(Cl)ccc46)CCCC5)c3[C@H](C1)C2 CHEMBL3216556 Kic 1.51 nM
CC1=CC2Cc3nc4cc(Cl)ccc4c(NCCCCCCNC(=O)c4cc(O)c5c(c4)C(=O)c4cccc(O)c4C5=O)c3C(C1)C2 CHEMBL3233827 IC50 1.52 nM
Clc1ccc2c(NCCCNCCCCCOc3cccc4[nH]c5ccccc5c34)c3c(nc2c1)CCCC3 CHEMBL473866 IC50 1.54 nM
CCN(CC)c1cc(/C=C2\OC(=O)c3cc(OC)c(OC)cc32)ccc1O CHEMBL4761887 IC50 1.55 nM
COc1ccc(Cn2cc(C(=O)NCCCNc3c4c(nc5cc(Cl)ccc35)CCCC4)c(=O)c3ccccc32)cc1 CHEMBL4210729 Ki 1.57 nM
CN(C)C(=O)N[C@H]1CCc2c(O)cccc2C1 CHEMBL3786937 Ki 1.59 nM
c1ccc2c(NCCCCCCCCNc3c4c(nc5ccccc35)CCCC4)c3c(nc2c1)CCCC3 CHEMBL75274 IC50 1.6 nM
c1ccc2c(NCCCCCCCCNc3c4c(nc5ccccc35)CCCCC4)c3c(nc2c1)CCCCC3 CHEMBL306492 IC50 1.6 nM
c1ccc2c(NCCCCCSSCCCCCNc3c4c(nc5ccccc35)CCCC4)c3c(nc2c1)CCCC3 CHEMBL4208641 IC50 1.62 nM
CC[N+](C)(C)c1cccc(O)c1 CHEMBL60745 Ki 1.63 nM
c1ccc2c(NCCc3ccc(CCNc4c5c(nc6ccccc46)CCCC5)cc3)c3c(nc2c1)CCCC3 CHEMBL490660 Ki 1.63 nM
COc1cc2oc(-c3ccc(NCCNc4c5c(nc6cc(Cl)ccc46)CCCC5)cc3)cc(=O)c2c(OC)c1OC CHEMBL4451532 IC50 1.63 nM
Clc1ccc2c(NCCCNCCCCOc3cccc4[nH]c5ccccc5c34)c3c(nc2c1)CCCC3 CHEMBL478667 IC50 1.65 nM
COc1cc(-c2cc3c(c(=O)o2)C[C@]2(O)[C@@]4(C)C(=O)C=CC(C)(C)[C@]4(O)CC[C@@]2(C)O3)cc(OC)c1OC CHEMBL24686 Ki 1.7 nM
Fc1ccccc1-c1ccc(N[C@H]2C[C@@H]3CN(CC4CCOCC4)C[C@@H]3C2)nn1 CHEMBL4851711 IC50 1.7 nM
c1cc(CCNc2c3c(nc4ccccc24)CCCC3)cc(CCNc2c3c(nc4ccccc24)CCCC3)c1 CHEMBL490264 Ki 1.718 nM
CN(C)C(=O)N[C@H]1CCc2ccc(O)cc2C1 CHEMBL3785207 Ki 1.74 nM
CCC1=CC2Cc3nc4cc(F)cc(F)c4c(N)c3C(C1)C2 CHEMBL335355 IC50 1.76 nM
C[N+](C)(CC#CCOC1=NOCC1)CCCCCCCCCCNc1c2c(nc3ccccc13)CCCC2 CHEMBL4287748 pIC50 1.778 nM
Nc1c2c(nc3cc(Cl)ccc13)CCCC2 CHEMBL292314 IC50 1.8 nM
CNC(=O)Oc1cccc(CN(C)CCCCCCCOc2ccc3c(c2)C/C(=C\c2cc(O)c(O)c(O)c2)C3=O)c1 CHEMBL1085938 IC50 1.8 nM
COc1cc2oc(C(=O)NCCCCCCCCCCNc3c4c(nc5ccccc35)CCCC4)cc(=O)c2cc1OC CHEMBL2019040 IC50 1.8 nM
CNC(=O)Oc1cccc(CN(C)CCCCCCCOc2ccc3c(c2)C/C(=C\c2cc(OC)c(OC)c(OC)c2)C3=O)c1 CHEMBL191461 IC50 1.8 nM
CN1c2ccc(OC(=O)NCC3CCCCC3)cc2[C@]2(C)CCN(CCc3ccccc3)[C@H]12 CHEMBL1081032 IC50 1.8 nM
Cc1ccc(O)cc1 CHEMBL16645 -Log IC50 1.82 nM
CC1=CC2Cc3nc4cc(Cl)ccc4c(NCCCCCCCCCNC(=O)c4ccc[nH]c4=O)c3C(C1)C2 CHEMBL4866930 IC50 1.82 nM
O=C(CCCNc1c2c(nc3ccccc13)CCCC2)CCCNc1c2c(nc3ccccc13)CCCC2 CHEMBL238230 IC50 1.83 nM
CC1=CC2Cc3nc4cc(Cl)ccc4c(NCCCCCCCNc4c5c(nc6ccccc46)CCCC5)c3C(C1)C2 CHEMBL3215882 IC50 1.89 nM
c1cnc2nc3c(c(NCCCCCCCCNc4c5c(nc6ncccc46)CCCC5)c2c1)CCCC3 CHEMBL75985 IC50 1.9 nM
COc1cc2oc(-c3ccc(NCCCNc4c5c(nc6cc(Cl)ccc46)CCCC5)cc3)cc(=O)c2c(OC)c1OC CHEMBL4466652 IC50 1.9 nM
O=C(NCCCCCCCCNc1c2c(nc3cc(Cl)ccc13)CCCC2)c1ccc2nc(-c3ccc(Cl)cc3)c3c(c2c1)OCCC3 CHEMBL3215768 Ki 1.91 nM
O=C(CC[C@H](NC(=O)CNC(=O)OCc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1)NCC(=O)Nc1cccc2c(NCCCCCCCCNc3c4c(nc5ccccc35)CCCC4)c3c(nc12)CCCC3 CHEMBL3099498 Ki 1.92 nM
CC1=CC2Cc3nc4cc(Cl)ccc4c(NCCCCCCCCCCCCNc4c5c(nc6ccccc46)CCCC5)c3C(C1)C2 CHEMBL3600551 IC50 1.92 nM
O=C1C=C(NCCNc2c3c(nc4cc(Cl)ccc24)CCCC3)C(=O)c2ccccc21 CHEMBL3356532 IC50 1.93 nM
COc1cc(CNC(=O)CCCCCCCNc2c3c(nc4cc(Cl)ccc24)CC2C=C(C)CC3C2)ccc1O CHEMBL4748114 IC50 1.94 nM
CC1=C[C@@H]2Cc3nc4cc(Cl)ccc4c(NCCCCC(=O)N4CCC(NC(=O)Nc5ccc(OC(F)(F)F)cc5)CC4)c3[C@H](C1)C2 CHEMBL5207628 IC50 1.94 nM
CNC(=O)Oc1cccc(CN(C)CCCCCCCOc2ccc3c(c2)O/C(=C\c2ccccc2)C3=O)c1 CHEMBL370961 IC50 1.95 nM
Cc1cccc(C)c1 CHEMBL286727 -Log IC50 1.995 nM
C[N+](C)(CC#CCOC1=NOCC1)CCCCCCCNc1c2c(nc3ccccc13)CCCC2 CHEMBL4283298 pIC50 1.995 nM
CCOc1ccc(Cc2nc3cc(C(=O)N(CC)CC)ccc3n2CCCCCCNc2c3c(nc4ccccc24)CCCC3)cc1 CHEMBL4456083 pIC50 1.995 nM
COc1cc2c(cc1OC)C(=O)C(CC1CCN(Cc3ccccc3)CC1)C2 CHEMBL502 IC50 2.0 nM
FC12CC3CC(NCCCCNc4c5c(nc6cc(Cl)ccc46)CCCC5)(CC(C1)c1ccccc13)C2 CHEMBL4469343 IC50 2.0 nM
O=c1c(NCCCCc2c3c(nc4cc(Cl)ccc24)CCCC3)c(NCCCCc2c3c(nc4ccc(Cl)cc24)CCCC3)c1=O CHEMBL5220250 IC50 2.0 nM
CC[N+](CC)(CCCCCn1c(=O)cc(C)n(CCCn2c(C)cc(=O)n(C)c2=O)c1=O)Cc1ccccc1C(F)(F)F CHEMBL5418455 IC50 2.0 nM
COc1cc2c(cc1O)CCC(C)(CC(=O)NCCCCCCCCCNc1c3c(nc4cc(Cl)ccc14)CCCC3)O2 CHEMBL4797814 IC50 2.05 nM
O=C(NCCCCCCCCNc1c2c(nc3cc(Cl)ccc13)CCCC2)c1ccc2nc(-c3ccc(Cl)cc3)c3c(c2c1)NCCC3 CHEMBL3322231 IC50 2.06 nM
CCC1=CC2Cc3nc4cc(F)ccc4c(N)c3C(C1)C2 CHEMBL341658 Log IC50 2.089 nM
CNC(=O)Oc1cccc(CN(C)CCCCCCCOc2ccc3c(c2)O/C(=C\c2cccc4ccccc24)C3=O)c1 CHEMBL364545 IC50 2.09 nM
CNC(=O)Oc1cccc(CN(C)CCCCCCCOc2ccc3c(c2)O/C(=C\c2ccc4ccccc4c2)C3=O)c1 CHEMBL1085933 IC50 2.09 nM
COc1nc(-c2ccnc(NC(=O)C3CC3)c2)sc1C(=O)NCCNc1c2c(nc3cc(Cl)ccc13)CCCC2 CHEMBL4282154 IC50 2.1 nM
COC1=C(C)C(=O)O/C1=C1\O[C@@]23CCCN4C(=O)CC[C@H](O2)[C@H]4[C@H]3[C@@H]1C CHEMBL1642206 MIC 2.11 nM
Clc1ccc2c(NCCCNCCCOc3cccc4[nH]c5ccccc5c34)c3c(nc2c1)CCCC3 CHEMBL478666 IC50 2.15 nM
O=C(CCCOc1cccc2[nH]c3ccccc3c12)NCCCNc1c2c(nc3ccccc13)CCCC2 CHEMBL3235502 IC50 2.15 nM
COc1cc2c(cc1OC)CC(CC1CCN(CCCNc3c4c(nc5ccccc35)CCCC4)CC1)C2 CHEMBL3216209 IC50 2.16 nM
CC1=CC2Cc3nc4cc(F)cc(F)c4c(N)c3C(C1)C2 CHEMBL143290 IC50 2.2 nM
O=C(Nc1ccccc1)c1ccc2c(c1)C(=O)N(CCC1CCN(Cc3ccccc3)CC1)C2=O CHEMBL1084256 IC50 2.2 nM
CCN(CCCNC1=CC(=O)C(NCCCN(CC)Cc2ccccc2OC)=CC1=O)Cc1ccccc1OC CHEMBL243271 IC50 2.25 nM
c1ccc2c(NCCCCC[Se]CCCCCNc3c4c(nc5ccccc35)CCCC4)c3c(nc2c1)CCCC3 CHEMBL4213042 IC50 2.25 nM
CCC(CC)n1cc(C(=O)C(F)(F)F)cn1 CHEMBL3623551 IC50 2.27 nM
O=C(NCCCCCCCCCCNc1c2c(nc3ccccc13)CCCC2)c1cc(=O)c2c(O)cc(O)cc2o1 CHEMBL2019047 IC50 2.3 nM
COc1cc(OC)c2c(=O)cc(C(=O)NCCCCCCCCCCNc3c4c(nc5ccccc35)CCCC4)oc2c1 CHEMBL2019037 IC50 2.3 nM
O=C(C[n+]1ccccc1)N/N=C/c1ccc(/C=N/NC(=O)C[n+]2ccccc2)cc1 CHEMBL3313966 IC50 2.3 nM
CCN(CCCCCNC1=CC(=O)C(NCCCCCN(CC)Cc2ccccc2OC)=CC1=O)Cc1ccccc1OC CHEMBL230702 IC50 2.36 nM
CC1=C[C@@H]2Cc3nc4cc(Cl)ccc4c(NCCCCCCCCCNC(=O)c4cc(O)c5c(c4)C(=O)c4cccc(O)c4C5=O)c3[C@H](C1)C2 CHEMBL3233832 IC50 2.39 nM
CC1=CC2Cc3nc4cc(Cl)ccc4c(NCCCCCCCCC(=O)Nc4cn[nH]c4)c3C(C1)C2 CHEMBL4863615 IC50 2.39 nM
O=C(c1ccccc1)c1ccc2c(c1)C(=O)N(CCC1CCN(Cc3ccccc3)CC1)C2=O CHEMBL140999 IC50 2.4 nM
CC1=C[C@@H]2Cc3nc4cc(Cl)ccc4c(NCCCCCCCCCNC(=O)c4cc(O)c5c(c4)C(=O)c4cccc(O)c4C5=O)c3[C@H](C1)C2 CHEMBL4113560 IC50 2.4 nM
CC1=CC2Cc3nc4cc(Cl)ccc4c(NCCCCCCCCCNS(=O)(=O)c4cn[nH]c4)c3C(C1)C2 CHEMBL4862716 IC50 2.4 nM
CC[C@H](O)[C@@H]1CC[C@@H]2O[C@@]34CCCN1[C@@H]2[C@H]3[C@H](C)/C(=C1/OC(=O)C(C)=C1OC)O4 CHEMBL467414 MIC 2.47 nM
c1ccc2c(NCCCCCCNc3c4c(nc5ncccc35)CCCCC4)c3c(nc2c1)CCCCC3 CHEMBL1083488 IC50 2.5 nM
NC12CC3CC(F)(CC(C1)c1cc(NC(=O)CCCCNc4c5c(nc6cc(Cl)ccc46)CCCC5)ccc13)C2 CHEMBL4591167 IC50 2.5 nM
O=C(CCC1CCN(Cc2ccccc2F)CC1)c1cc2c3c(ccn3C(=O)CC2)c1 CHEMBL1651131 pIC50 2.512 nM
COC(=O)c1c(CCCCCCCCNc2c3c(nc4cc(Cl)ccc24)CCCC3)cccc1OC CHEMBL5078555 IC50 2.54 nM
COc1cccc2cc(CNCCCCCCCNc3c4c(nc5ccccc35)CCCCC4)oc12 CHEMBL3753405 IC50 2.56 nM
COc1cc2c(cc1OC)SC(C(=O)CCc1cc[n+](Cc3ccc(F)cc3)cc1)C2 CHEMBL187818 Log Ki 2.57 nM
Clc1ccc2c(NCCCNCCCCCCOc3cccc4[nH]c5ccccc5c34)c3c(nc2c1)CCCC3 CHEMBL474268 IC50 2.57 nM
CC1=CC2Cc3nc4cc(Cl)ccc4c(NCCCCCCCCCNC(=O)c4cc(O)cc(O)c4)c3C(C1)C2 CHEMBL4859103 IC50 2.57 nM
COc1cc2cc(C(=O)CCc3cc[n+](Cc4ccc(F)cc4)cc3)sc2cc1OC CHEMBL87849 IC50 2.6 nM
c1ccc2c(NCCc3ccc(OCCCN4CCCCC4)cc3)c3c(nc2c1)CCCC3 CHEMBL15056 IC50 2.6 nM
COc1cc2c(cc1OC)CC(CC1CCN(CCNc3c4c(nc5cc(Cl)ccc35)CCCC4)CC1)C2 CHEMBL3216210 IC50 2.6 nM
O=C(Nc1cncc(OCC2CCN(Cc3ccccc3)CC2)c1)c1ccnc(NC(=O)C2CC2)c1 CHEMBL4863960 IC50 2.6 nM
COc1cc2c(cc1OC)CC(CC1CCN(CCCNc3c4c(nc5cc(Cl)ccc35)CC3C=C(C)CC4C3)CC1)C2 CHEMBL5276338 IC50 2.61 nM
c1ccc2c(NCCCCC[Se][Se]CCCCCNc3c4c(nc5ccccc35)CCCC4)c3c(nc2c1)CCCC3 CHEMBL4204315 IC50 2.64 nM
CCN(CCCCCCNC1=C(Br)C(=O)C(NCCCCCCN(CC)Cc2ccccc2OC)=C(Br)C1=O)Cc1ccccc1OC CHEMBL243062 IC50 2.66 nM
O=C(CCCCc1cccs1)NCCCNc1c2c(nc3cc(Cl)ccc13)CCCC2 CHEMBL1912060 IC50 2.66 nM
c1ccc2c(NCCCCNCCCSc3c4c(nc5ccccc35)CCCC4)c3c(nc2c1)CCCC3 CHEMBL482512 Ki 2.672 nM
c1ccc2c(NCCCCCCCNc3c4c(nc5ccccc35)CCCCC4)c3c(nc2c1)CCCCC3 CHEMBL307908 IC50 2.7 nM
COc1cc2c(cc1O)C(=O)C(Cc1cc[n+](Cc3cccc(Cl)c3)cc1C(C)=O)C2 CHEMBL4159705 IC50 2.7 nM
O=C(/C=C/c1ccc([N+](=O)[O-])cc1)NCCCCCCNc1c2c(nc3ccccc13)CCCC2 CHEMBL4533477 IC50 2.7 nM
O=C(Nc1ccc(OC(F)(F)F)cc1)NC1CCN(C(=O)CCCNc2c3c(nc4cc(Cl)ccc24)CCCC3)CC1 CHEMBL5200047 IC50 2.71 nM
C[C@@H]1C(=O)O[C@@]23CCCN4CCC[C@H](O2)[C@H]4[C@@H]13 CHEMBL1642205 MIC 2.77 nM
COc1cc2c(cc1OC)C(=O)C(CC1(F)CCN(Cc3ccc(F)cc3)CC1)C2 CHEMBL4857791 Kd 2.78 nM
CC(=O)Nc1ccc2c(CCC3CCN(Cc4ccccc4)CC3)noc2c1 CHEMBL92736 Log IC50(nM) 2.799 nM
CC(=O)Nc1ccc2c(CCC3CCN(Cc4ccccc4)CC3)noc2c1 CHEMBL94217 IC50 2.8 nM
CC(=O)Nc1ccc2c(c1)C(=O)N(CCC1CCN(Cc3ccccc3)CC1)C2=O CHEMBL433678 IC50 2.8 nM
CN(CCCOc1ccc2c(=O)c3ccccc3oc2c1)Cc1cccc(OC(=O)Nc2ccccc2)c1 CHEMBL128260 IC50 2.8 nM
O=C(COc1cc(F)ccc1[N+](=O)[O-])NCCN1CCN(Cc2ccccc2)CC1 CHEMBL5189408 IC50 2.8 nM
COC(=O)c1c(O)cccc1CCCCCCCCNc1c2c(nc3cc(Cl)ccc13)CCCC2 CHEMBL5082773 IC50 2.81 nM
O=C(CCC1CCN(Cc2cccc([N+](=O)[O-])c2)CC1)c1cc2c3c(ccn3C(=O)CC2)c1 CHEMBL1651243 pIC50 2.884 nM
CN(CCCNC(=O)CCc1c[nH]c2ccccc12)CCCNc1c2c(nc3cc(Cl)ccc13)CCCC2 CHEMBL388551 IC50 2.9 nM
COc1cc2c(cc1OC)C(=O)/C(=C/c1cc[n+](Cc3cccc(F)c3)cc1)C2 CHEMBL4095035 IC50 2.9 nM
COc1cc2c(cc1OC)C(=O)C(Cc1cc[n+](Cc3ccccc3)cc1C#N)C2 CHEMBL4071377 IC50 2.92 nM
COc1cc(CNC(=O)CCCCCCCCNc2c3c(nc4cc(Cl)ccc24)CC2C=C(C)CC3C2)ccc1O CHEMBL4782921 IC50 2.94 nM
CNC(=O)Oc1cccc(CN(C)CCCOc2ccc3c(c2)O/C(=C\c2cc(O)c(O)c(O)c2)C3=O)c1 CHEMBL1083374 IC50 2.99 nM
CN1CCC(/C=C/C=C2\Cc3ccccc3C2=O)CC1 CHEMBL155746 IC50 3.0 nM
Cc1c(Cl)nc2ccccc2c1C(=O)NCCCCCCCNc1c2c(nc3ccccc13)CCCC2 CHEMBL195418 IC50 3.0 nM
O=C(CCOCCc1c[nH]c2ccccc12)NCCCCCCCNc1c2c(nc3cc(Cl)ccc13)CCCC2 CHEMBL1084545 IC50 3.0 nM
COc1cccc(CN(C)[C@@H](C)[C@H]2[C@H](O)C[C@@]3(C)[C@@H]4CC[C@H]5[C@]6(C)CSC(C(C)C)=N[C@H]6CC[C@@]56C[C@@]46C(=O)C[C@]23C)c1 CHEMBL1783514 IC50 3.0 nM
CC(C)C1=N[C@H]2CC[C@]34C[C@]35C(=O)C[C@]3(C)[C@@H]([C@H](C)N(C)Cc6cccc(C(F)(F)F)c6)[C@H](O)C[C@@]3(C)[C@@H]5CC[C@H]4[C@]2(C)CS1 CHEMBL1783517 IC50 3.0 nM
CC(C)C1=N[C@H]2CC[C@]34C[C@]35C(=O)C[C@]3(C)[C@@H]([C@H](C)N(C)Cc6ccc(C(F)(F)F)cc6)[C@H](O)C[C@@]3(C)[C@@H]5CC[C@H]4[C@]2(C)CS1 CHEMBL1783518 IC50 3.0 nM
COc1ccc([C@H]2O[C@@H](O)[C@H]3[C@@H]2C(=O)O[C@@H]3c2cc(OC)c3c(c2)OCO3)cc1OC CHEMBL4634863 IC50 3.0 nM
CCN(CCCCCCNC1=C(Cl)C(=O)C(NCCCCCCN(CC)Cc2ccccc2OC)=C(Cl)C1=O)Cc1ccccc1OC CHEMBL243056 IC50 3.05 nM
Nc1c2c(nc3ccccc13)CCCC2 CHEMBL95 IC50 3.16 nM
CCOc1ccc(Cc2nc3cc(C(=O)N(CC)CC)ccc3n2CCCNc2c3c(nc4ccccc24)CCCC3)cc1 CHEMBL4458929 pIC50 3.162 nM
CCOc1ccc(Cc2nc3cc(C(=O)NCCCNc4c5c(nc6ccccc46)CCCC5)ccc3n2CCC(C)C)cc1 CHEMBL4441666 pIC50 3.162 nM
CC1=CC2Cc3nc4cc(Cl)ccc4c(NCCCCCCCNC(=O)c4cc(O)c5c(c4)C(=O)c4cccc(O)c4C5=O)c3C(C1)C2 CHEMBL3233828 IC50 3.18 nM
O=C1C(Cl)=C(NCCNc2c3c(nc4cc(Cl)ccc24)CCCC3)C(=O)c2ccccc21 CHEMBL3356951 IC50 3.21 nM
O=c1c(O)c(-c2ccc(F)cc2)oc2cc(F)c(I)cc12 CHEMBL5282833 IC50 3.23 nM
CC1=CC2Cc3nc4cc(Cl)ccc4c(NCCCCCCCCCNc4c5c(nc6cc(Cl)ccc46)CCCC5)c3C(C1)C2 CHEMBL3216778 IC50 3.26 nM
COc1cc2c(cc1OC)C(=O)C(Cc1cc[n+](Cc3cccc(Cl)c3)cc1C(C)=O)C2 CHEMBL4102333 IC50 3.27 nM
COc1cccc(C2CC(c3cc(F)ccc3F)=NN2c2ccc(S(N)(=O)=O)cc2)c1OC CHEMBL4876038 Ki 3.28 nM
COc1ccc(C2CC(c3cc(F)ccc3F)=NN2c2ccc(S(N)(=O)=O)cc2)c(OC)c1 CHEMBL4847624 Ki 3.28 nM
COc1ccc(OC)c(C2CC(c3cc(F)ccc3F)=NN2c2ccc(S(N)(=O)=O)cc2)c1 CHEMBL4869398 Ki 3.28 nM
COc1ccc(C2CC(c3cc(F)ccc3F)=NN2c2ccc(S(N)(=O)=O)cc2)cc1OC CHEMBL4849196 Ki 3.28 nM
COc1cccc(C2CC(c3cc(F)cc(F)c3)=NN2c2ccc(S(N)(=O)=O)cc2)c1OC CHEMBL4857592 Ki 3.28 nM
COc1ccc(C2CC(c3cc(F)cc(F)c3)=NN2c2ccc(S(N)(=O)=O)cc2)c(OC)c1 CHEMBL4847613 Ki 3.28 nM
COc1ccc(OC)c(C2CC(c3cc(F)cc(F)c3)=NN2c2ccc(S(N)(=O)=O)cc2)c1 CHEMBL4872387 Ki 3.28 nM
COc1ccc(C2CC(c3cc(F)cc(F)c3)=NN2c2ccc(S(N)(=O)=O)cc2)cc1OC CHEMBL4864555 Ki 3.28 nM
CCN(CCCCCC(=O)N1CCC(C2CCN(C(=O)CCCCCN(CC)Cc3ccccc3OC)CC2)CC1)Cc1ccccc1OC CHEMBL254016 IC50 3.3 nM
CCN(CCCCCC(=O)N1CCC(CC2CCN(C(=O)CCCCCN(CC)Cc3ccccc3OC)CC2)CC1)Cc1ccccc1OC CHEMBL222946 Log IC50 3.311 nM
CCN(CCCCCC(=O)N1CCC(C2CCN(C(=O)CCCCCN(CC)Cc3ccccc3OC)CC2)CC1)Cc1ccccc1OC CHEMBL222904 Log IC50 3.311 nM
COc1cc2c(cc1OC)C(=O)/C(=C/c1cc[n+](Cc3ccccc3)cc1)C2 CHEMBL4098703 IC50 3.4 nM
CNC(=O)Oc1cccc(CN(C)CCCOc2ccc3c(c2)O/C(=C\c2ccc4ccccc4c2)C3=O)c1 CHEMBL191386 IC50 3.41 nM
O=c1c(O)c(-c2ccc(Cl)cc2)oc2cc(F)c(I)cc12 CHEMBL5274465 IC50 3.45 nM
CC1=CC2Cc3nc4cc(Cl)ccc4c(NCCCCCCCCCCCCNc4c5c(nc6cc(Cl)ccc46)CCCC5)c3C(C1)C2 CHEMBL3600552 IC50 3.46 nM
COc1cc2c(cc1OC)C(=O)C(CC1(F)CCN(Cc3ccc(F)cc3F)CC1)C2 CHEMBL4877719 Kd 3.47 nM
O=C(c1c2ccccc2cc2ccccc12)N1c2ccccc2Sc2ccccc21 CHEMBL392577 Ki 3.5 nM
COc1cc2c(cc1OC)C(=O)C(CC1(F)CCN(Cc3ccccc3F)CC1)C2 CHEMBL4859647 Kd 3.5 nM
CN(C)c1ccccc1CNCCCCCCCCCNc1c2c(nc3ccccc13)CCCC2 CHEMBL2147462 IC50 3.52 nM
CC1=CC2Cc3nc4cc(Cl)ccc4c(NCCCCCCCCCNc4c5c(nc6ccccc46)CCCC5)c3C(C1)C2 CHEMBL3216116 IC50 3.53 nM
O=C1Cc2c(ccc3c(CCC4CCN(Cc5ccccc5)CC4)noc23)N1 CHEMBL95020 IC50 3.6 nM
CC1=CC2Cc3nc4cc(Cl)ccc4c(NCCCCCCCCCNC(=O)c4cc(O)c5c(c4)C(=O)c4cccc(O)c4C5=O)c3C(C1)C2 CHEMBL3233830 IC50 3.6 nM
CC1=CC2Cc3nc4cc(Cl)ccc4c(NCCCCCCCCCNC(=O)c4cc(O)c5c(c4)C(=O)c4cccc(O)c4C5=O)c3C(C1)C2 CHEMBL3304306 IC50 3.6 nM
COc1cc2c(cc1OC)C(=O)/C(=C/c1cc[n+](Cc3cccc([N+](=O)[O-])c3)cc1)C2 CHEMBL4101018 IC50 3.6 nM
COc1nc(-c2ccnc(NC(=O)C3CC3)c2)sc1C(=O)NCCCNc1c2c(nc3cc(Cl)ccc13)CCCC2 CHEMBL4293418 IC50 3.6 nM
c1ccc2c(NCc3ccc(-c4ccc(CNc5c6c(nc7ccccc57)CCCC6)cc4)cc3)c3c(nc2c1)CCCC3 CHEMBL4456928 IC50 3.61 nM
O=C(CCC1CCN(Cc2ccccc2)CC1)c1cc2c3c(c1)CC(=O)N3CCC2 CHEMBL1651129 pIC50 3.631 nM
CC1=CC2Cc3nc4ccccc4c(NCCCCCCCCCCCCNc4c5c(nc6cc(Cl)ccc46)CCCC5)c3C(C1)C2 CHEMBL3600556 IC50 3.66 nM
COc1cc2c(cc1O)CCC(C)(CC(=O)NCCCCCCCCNc1c3c(nc4cc(Cl)ccc14)CCCC3)O2 CHEMBL4787579 IC50 3.69 nM
CC(=O)NCCc1c[nH]c2ccc(OC(=O)NCCCCCCCCCCCCNc3c4c(nc5ccccc35)CCCC4)cc12 CHEMBL3642053 IC50 3.8 nM
COc1cc2c(cc1OC)C(=O)/C(=C/c1cc[n+](Cc3ccccc3Br)cc1)C2 CHEMBL4063583 IC50 3.8 nM
COc1cc2c(cc1O)CCC(C)(CCC(=O)NCCCCCCNc1c3c(nc4cc(Cl)ccc14)CCCC3)O2 CHEMBL4762419 IC50 3.8 nM
CCC1=CC2Cc3nc4cc(Cl)ccc4c(NCCCN4CCC(CC5Cc6cc(OC)c(OC)cc6C5)CC4)c3C(C1)C2 CHEMBL5268897 IC50 3.85 nM
O=C(Nc1cncc(OCC2CCN(Cc3ccccc3)CC2)c1)c1ccnc2[nH]ccc12 CHEMBL4877175 IC50 3.9 nM
COc1cc2c(cc1OC)C(c1cccc([N+](=O)[O-])c1)N(CCCCCCc1cn(CCNc3c4c(nc5cc(Cl)ccc35)CC3C=C(C)CC4C3)nn1)CC2 CHEMBL575802 IC50 3.95 nM
Cc1cccc([N+](=O)[O-])c1 CHEMBL114059 -Log IC50 3.981 nM
CN(CCCCSc1c2c(nc3ccccc13)CCCC2)CCCNc1c2c(nc3ccccc13)CCCC2 CHEMBL175555 Ki 3.99 nM
CCCN(CCCOc1ccc2c(=O)c3ccccc3oc2c1)Cc1cccc(OC(=O)NC)c1 CHEMBL131219 IC50 4.0 nM
O=C(CCc1c[nH]c2ccccc12)NCCCCCNc1c2c(nc3cc(Cl)ccc13)CCCC2 CHEMBL224335 IC50 4.0 nM
COc1cc2c(cc1OC)C(=O)/C(=C/c1cc[n+](Cc3cccc(C)c3)cc1)C2 CHEMBL4084842 IC50 4.0 nM
CNC(=O)Oc1ccc2c(c1)[C@]1(C)CCOC1N2C CHEMBL362444 IC50 4.0 nM
CNC(=O)Oc1ccc2c(c1)[C@]1(C)CCO[C@@H]1N2C CHEMBL205231 IC50 4.0 nM
CC1=CC2Cc3nc4cc(Cl)ccc4c(NCCCCCCCNc4c5c(nc6cc(Cl)ccc46)CCCC5)c3C(C1)C2 CHEMBL3216555 IC50 4.02 nM
CCN(CCCCCCNC1=CC(=O)C(NCCCCCCN(CC)[C@@H](C)c2ccccc2OC)=CC1=O)[C@@H](C)c1ccccc1OC CHEMBL556581 IC50 4.03 nM
CN(C)c1ccccc1CNCCCCCCCCNc1c2c(nc3ccccc13)CCCC2 CHEMBL2147461 IC50 4.04 nM
O=C(CNCCCc1ccccc1)Nc1ccc2nc3n(c(=O)c2c1)CCC3 CHEMBL4210020 IC50 4.09 nM
Cc1c(N2CCN(C)CC2)nc2ccccc2c1C(=O)NCCCCCCCNc1c2c(nc3ccccc13)CCCC2 CHEMBL195241 IC50 4.1 nM
O=C(Cc1cc(=O)oc2cc(O)ccc12)NCCCCNc1c2c(nc3ccccc13)CCCC2 CHEMBL3322160 Ki 4.1 nM
COc1cc2c(cc1OC)C(=O)/C(=C/c1cc[n+](Cc3ccc(F)cc3)cc1)C2 CHEMBL4073287 IC50 4.1 nM
COc1ccc(CNC(=O)C2CCN(C(=O)c3ccccc3)CC2)cc1OC CHEMBL4455013 IC50 4.11 nM
COc1ccc(NC(=O)C2CCN(C(=O)c3ccccc3)CC2)cc1OC CHEMBL1613299 IC50 4.11 nM
CC1=CC2Cc3nc4cc(Cl)ccc4c(NCCCCCCCCCCNc4c5c(nc6ccccc46)CCCC5)c3C(C1)C2 CHEMBL3216554 IC50 4.19 nM
Oc1cccc(CCCCCCCCNc2c3c(nc4cc(Cl)ccc24)CCCC3)c1 CHEMBL5072428 IC50 4.19 nM
CN1CCC(CCC2C(=O)Nc3ccccc3C2=O)CC1 CHEMBL158252 IC50 4.2 nM
O=c1[nH]c2ccccc2c(=O)n1CCC1CCN(Cc2ccccc2)CC1 CHEMBL342413 IC50 4.2 nM
CC[C@@H](CN1CCCC1=O)C(=O)NCCCCCCCNc1c2c(nc3cc(Cl)ccc13)C[C@H]1C=C(C)C[C@@H]2C1 CHEMBL4569343 IC50 4.2 nM
CCn1c(C)nc2cc(C(=O)CCC3CCN(Cc4ccccc4)CC3)ccc21 CHEMBL1082435 pIC50 4.266 nM
CCn1c(C)nc2cc(C(=O)CCC3CCN(Cc4ccccc4)CC3)ccc21 CHEMBL555075 IC50 4.3 nM
COc1cc(CNC(=O)CCCCCNc2c3c(nc4cc(Cl)ccc24)CC2C=C(C)CC3C2)ccc1O CHEMBL4788434 IC50 4.35 nM
CC1=CC2Cc3nc4cc(Cl)ccc4c(NCCCCCCCCNC(=O)c4cc(O)c5c(c4)C(=O)c4cccc(O)c4C5=O)c3C(C1)C2 CHEMBL3233829 IC50 4.36 nM
O=C(CCc1c[nH]c2ccccc12)NCCCCCCCCCNc1c2c(nc3cc(Cl)ccc13)CCCC2 CHEMBL1084262 IC50 4.4 nM
CC1=CC2Cc3nc4cc(Cl)ccc4c(NCCCCCCCCNC(=O)c4cc(O)c5c(c4)C(=O)c4cccc(O)c4C5=O)c3C(C1)C2 CHEMBL3304357 IC50 4.4 nM
COc1cc(CNC(=O)CCCC/C=C/CNc2c3c(nc4cc(Cl)ccc24)CC2C=C(C)CC3C2)ccc1O CHEMBL4741162 IC50 4.41 nM
Nc1c2c(nc3cc(Cl)ccc13)C1CCC2C1 CHEMBL352500 Log IC50 4.467 nM
COc1cc2c(cc1OC)SC(C(=O)CCc1cc[n+](Cc3coc([N+](=O)[O-])c3)cc1)C2 CHEMBL610242 Log Ki 4.467 nM
O=C(CCNCCNc1c2c(nc3ccccc13)CCCC2)N1CCN(CCNc2c3c(nc4ccccc24)CCCC3)CC1 CHEMBL2064471 IC50 4.49 nM
COc1cc2cc(C(=O)CCc3cc[n+](Cc4ccc([N+](=O)[O-])o4)cc3)sc2cc1OC CHEMBL609440 IC50 4.5 nM
O=c1[nH]c2cc(Cl)ccc2c(=O)n1CCC1CCN(Cc2ccccc2)CC1 CHEMBL138552 IC50 4.5 nM
COc1cc2c(cc1OC)SC(C(=O)CCc1cc[n+](Cc3ccccc3)cc1)C2 CHEMBL186042 Log Ki 4.571 nM
O=C(CCC1CCN(Cc2ccc(F)cc2)CC1)c1cc2c3c(ccn3C(=O)CC2)c1 CHEMBL1651248 pIC50 4.571 nM
CC1=C[C@@H]2Cc3nc4cc(F)ccc4c(N)c3[C@H](C1)C2 CHEMBL4524111 IC50 4.58 nM
COc1cc2cc(C(=O)CCc3cc[n+](Cc4ccccc4)cc3)sc2cc1OC CHEMBL87170 IC50 4.6 nM
CC(=O)NCCc1c[nH]c2ccc(OC(=O)NCCCCCCCCNc3c4c(nc5ccccc35)CCCC4)cc12 CHEMBL3642049 IC50 4.61 nM
COc1cc2c(cc1OC)C(=O)C(CC1(F)CCN(Cc3ccccc3)CC1)C2 CHEMBL4846450 Kd 4.61 nM
c1cc[n+](CCCCCCCCCCCC[n+]2cccc3ccccc32)cc1 CHEMBL3093804 IC50 4.7 nM
O=C(Nc1cncc(OCC2CCN(Cc3ccccc3F)CC2)c1)c1ccnc(NC(=O)C2CC2)c1 CHEMBL4865061 IC50 4.7 nM
c1cnc2nc3c(c(NCCCCCCNc4c5c(nc6ncccc46)CCCC5)c2c1)CCCC3 CHEMBL75305 IC50 4.8 nM
CCN(CCCCCC(=O)N1Cc2ccc3c4c(ccc(c24)C1)CN(C(=O)CCCCCN(CC)Cc1ccccc1OC)C3)Cc1ccccc1OC CHEMBL507885 IC50 4.83 nM
O=C(CCC1CCN(Cc2cccc(Cl)c2)CC1)c1cc2c3c(ccn3C(=O)CC2)c1 CHEMBL1651134 pIC50 4.898 nM
CCCNC(=O)c1sc(-c2ccnc(NC(=O)CNCCNc3c4c(nc5ccccc35)CCCC4)c2)nc1OCC1CC1 CHEMBL4746403 IC50 4.9 nM
CC12CC3CC(C)(C1)CC(N)(C3)C2 CHEMBL807 IC50 4.9 nM
CNC(=O)Oc1cccc(CN(C)CCCCCCCOc2ccc3c(c2)CC/C(=C/c2cc(O)c(O)c(O)c2)C3=O)c1 CHEMBL1085940 IC50 4.94 nM
CCC1=CC2Cc3nc4cc(C)cc(C)c4c(N)c3C(C1)C2 CHEMBL143094 IC50 4.96 nM
CC(C)(C)c1cc[n+](CCCCCCCC[n+]2ccc(C(C)(C)C)cc2)cc1 CHEMBL1642977 IC50 5.0 nM
c1ccc2c[n+](CCCCCCCC[n+]3ccc4ccccc4c3)ccc2c1 CHEMBL1669486 IC50 5.0 nM
CCCCCCCNC(=O)Oc1ccc2c(c1)[C@]1(C)CCN(C)[C@@H]1N2C CHEMBL433041 IC50 5.0 nM
c1cc[n+](CCCCCCCCCC[n+]2cccc3ccccc32)cc1 CHEMBL3093802 IC50 5.0 nM
CC(C)(C)c1cccc(C(=O)C(F)(F)F)c1 CHEMBL89354 IC50 5.0 nM
CN(CCCCNc1c2c(nc3ccccc13)CCCC2)CCCNc1c2c(nc3c(NC(=O)CNC(=O)CC[C@H](NC(=O)CNC(=O)OCc4ccccc4)C(=O)N[C@@H](Cc4ccccc4)C(=O)OCc4ccccc4)cccc13)CCCC2 CHEMBL3099499 Ki 5.02 nM
COc1cc2c(cc1OC)C(=O)C(CC1(F)CCN(Cc3cccc(F)c3)CC1)C2 CHEMBL4853698 Kd 5.02 nM
c1ccc2c(NCCSSCCNc3c4c(nc5ccccc35)CCCC4)c3c(nc2c1)CCCC3 CHEMBL3235503 IC50 5.04 nM
COc1cc(C(=O)NCCCCCCCCC(=O)NNc2c3c(cc4ccccc24)CCCC3)cc(OC)c1OC CHEMBL374981 IC50 5.08 nM
COc1cc(CCCCCCCCNc2c3c(nc4cc(Cl)ccc24)CCCC3)cc(OC)c1 CHEMBL5077234 IC50 5.1 nM
O=C(CCC1CCN(Cc2ccccc2Cl)CC1)c1cc2c3c(ccn3C(=O)CC2)c1 CHEMBL1651133 pIC50 5.129 nM
COc1cc2c(cc1OC)CC(CC1CCN(CCNc3c4c(nc5ccccc35)CCCC4)CC1)C2 CHEMBL3216208 IC50 5.13 nM
CC(=O)N(CCCCSc1c2c(nc3ccccc13)CCCC2)CCCNc1c2c(nc3ccccc13)CCCC2 CHEMBL175949 Ki 5.15 nM
COc1cc2oc(-c3ccc(NCCCCNc4c5c(nc6cc(Cl)ccc46)CCCC5)cc3)cc(=O)c2c(OC)c1OC CHEMBL4569511 IC50 5.15 nM
CCN(CCCCCCNC1=C(F)C(=O)C(NCCCCCCN(CC)Cc2ccccc2OC)=C(F)C1=O)Cc1ccccc1OC CHEMBL243055 IC50 5.17 nM
CN(C)c1ccccc1CNCCCCCCCNc1c2c(nc3ccccc13)CCCC2 CHEMBL2147460 IC50 5.18 nM
O=C(c1cnn(C2CCCC2)c1)C(F)(F)F CHEMBL3623552 IC50 5.2 nM
COc1cc2c(cc1OC)C(=O)/C(=C/c1cc[n+](Cc3cccc(Br)c3)cc1)C2 CHEMBL4082048 IC50 5.2 nM
COc1cc2c(cc1OC)C(=O)C(CC1(F)CCN(Cc3cc(F)c(F)cc3F)CC1)C2 CHEMBL4857100 Kd 5.23 nM
COc1cc(C(=O)NCCCCCCCC(=O)NNc2c3c(nc4ccccc24)CCCC3)cc(OC)c1OC CHEMBL216159 IC50 5.24 nM
Cc1ccccc1 CHEMBL9113 -Log IC50 5.248 nM
COc1cc2c(cc1OC)C(=O)C(C)C2 CHEMBL154848 -Log IC50 5.248 nM
CN1CCC(C[C@@H]2Cc3ccccc3C2=O)CC1 CHEMBL153865 IC50 5.3 nM
CC1CCN(Cc2ccccc2)CC1 CHEMBL158232 IC50 5.3 nM
CCCCCCCCCCCCCCCCNCC(=O)Nc1ccc2nc3n(c(=O)c2c1)CCC3 CHEMBL4205426 IC50 5.31 nM
CNC(=O)Oc1cccc(CN(C)CCCOc2ccc(C(=O)c3ccccc3)cc2)c1 CHEMBL544592 IC50 5.4 nM
O=C(c1ccc([N+](=O)[O-])cc1)N(CCC1CCN(Cc2ccccc2)CC1)c1ccccc1 CHEMBL126354 IC50 5.4 nM
CNC(=O)Oc1cccc(CN(C)CCCOc2ccc(C(=O)c3ccccc3)cc2)c1 CHEMBL1086245 IC50 5.4 nM
O=C1C=C(NCCCNc2c3c(nc4cc(Cl)ccc24)CCCC3)C(=O)c2ccccc21 CHEMBL3356533 IC50 5.4 nM
COc1cc2c(cc1O)CCC(C)(CC(=O)NCCCCCCCNc1c3c(nc4cc(Cl)ccc14)CCCC3)O2 CHEMBL4798535 IC50 5.43 nM
CC[N+](CC)(CC)CCOc1ccc(C(=O)NCCCCCC(=O)NNc2c3c(nc4cc(Cl)ccc24)CCCC3)cc1 CHEMBL540131 IC50 5.44 nM
COc1cc(CNC(=O)CCCCNc2c3c(nc4cc(Cl)ccc24)CC2C=C(C)CC3C2)ccc1O CHEMBL4743210 IC50 5.48 nM
Oc1c(CNCCCCCCCCCNc2c3c(nc4ccccc24)CCCC3)ccc2cccnc12 CHEMBL3215602 IC50 5.5 nM
Cc1cc(=O)[nH]c2c1C(=O)C(NCCCCNc1c3c(nc4cc(Cl)ccc14)CCCC3)=CC2=O CHEMBL5423918 IC50 5.58 nM
O=[N+]([O-])OCCCNCCCCNc1c2c(nc3ccccc13)CCCC2 CHEMBL407320 IC50 5.6 nM
COc1cc(CNC(=O)CCCC/C=C/CCCNc2c3c(nc4cc(Cl)ccc24)CC2C=C(C)CC3C2)ccc1O CHEMBL4794769 IC50 5.64 nM
COc1cc(C(=O)NCCCCCCC(=O)NNc2c3c(nc4ccccc24)CCCC3)cc(OC)c1OC CHEMBL219569 IC50 5.65 nM
CNC(=O)Oc1cccc(CN(C)CCCOc2ccc3ccc(=O)oc3c2)c1 CHEMBL340625 IC50 5.7 nM
CNC(=O)Oc1cccc(CN(C)CCCOc2ccc3c(=O)cc(-c4ccccc4)oc3c2)c1 CHEMBL128471 IC50 5.7 nM
COc1cc2c(cc1OC)C(=O)C(CC1CCN(c3ccccc3)CC1)C2 CHEMBL1083982 IC50 5.7 nM
COc1cccc(CCCCCCCCNc2c3c(nc4cc(Cl)ccc24)CCCC3)c1 CHEMBL5088557 IC50 5.71 nM
COc1cc2onc(CCC3CCN(Cc4ccccc4)CC3)c2cc1C CHEMBL188823 Log Ki 5.754 nM
CC[N+](C)(CCCCCC(=O)N1CCC(CCCC2CCN(C(=O)CCCCC[N+](C)(CC)Cc3ccccc3OC)CC2)CC1)Cc1ccccc1OC CHEMBL221992 Log IC50 5.754 nM
CC[N+](C)(CCCCCC(=O)N1CCC(CCC2CCN(C(=O)CCCCC[N+](C)(CC)Cc3ccccc3OC)CC2)CC1)Cc1ccccc1OC CHEMBL19949 Log IC50 5.754 nM
Cc1cc2onc(CCC3CCN(Cc4ccccc4)CC3)c2cc1C CHEMBL91291 pIC50 5.754 nM
COC(=O)c1c[n+](Cc2ccccc2C)ccc1CC1Cc2cc(OC)c(OC)cc2C1=O CHEMBL4095535 IC50 5.8 nM
COc1cc2c(cc1OC)C(=O)/C(=C/c1cc[n+](Cc3ccccc3C)cc1)C2 CHEMBL4099391 IC50 5.8 nM
CCC1=CC2Cc3nc4cc(Cl)ccc4c(NCCn4cc(CCCCCCN5CCc6cc(OC)c(OC)cc6C5c5cccc([N+](=O)[O-])c5)nn4)c3C(C1)C2 CHEMBL575674 IC50 5.96 nM
COc1cc2cc(C(=O)CCc3cc[n+](Cc4ccsc4)cc3)sc2cc1OC CHEMBL87649 IC50 6.0 nM
COc1cc2c(cc1OC)SC(C(=O)CCc1cc[n+](Cc3ccsc3)cc1)C2 CHEMBL362752 IC50 6.0 nM
CN(CCOCCNC(=S)NC(=O)c1ccc2c(c1)C(=O)c1ccccc1C2=O)Cc1ccccc1 CHEMBL1085031 IC50 6.0 nM
CC(C)c1ccc(NC(=O)Oc2ccc3c(c2)[C@]2(C)CCN(CCc4ccccc4)[C@@H]2N3C)cc1 CHEMBL1080386 IC50 6.0 nM
COc1ccccc1CN(C)[C@@H](C)[C@H]1[C@H](O)C[C@@]2(C)[C@@H]3CC[C@H]4[C@]5(C)CSC(C(C)C)=N[C@H]5CC[C@@]45C[C@@]35C(=O)C[C@]12C CHEMBL1783528 IC50 6.0 nM
CN(C)C(=O)Oc1cccc2c1cc(C(=O)NCCOCCOCCN1C(=O)c3ccccc3C1=O)c[n+]2C CHEMBL4168520 IC50 6.0 nM
CCNC(=O)Oc1ccc2c(c1)[C@]1(C)CCOC1O2 CHEMBL5090683 IC50 6.0 nM
CC(C)(C)c1cccc(C(=O)C(F)F)c1 CHEMBL3623554 IC50 6.05 nM
O=S(=O)(c1ccccc1)n1ccc2c(N3CCN(CCCCCCCNc4c5c(nc6ccccc46)CCCC5)CC3)cccc21 CHEMBL3884690 IC50 6.2 nM
N[C@@H](CCC(=O)NCCNc1c2c(nc3ccccc13)CCCC2)C(=O)NCCNc1c2c(nc3ccccc13)CCCC2 CHEMBL397271 Ki 6.21 nM
COc1cc2c(cc1O)CCC(C)(CCC(=O)NCCCCCCCCNc1c3c(nc4cc(Cl)ccc14)CCCC3)O2 CHEMBL4794645 IC50 6.23 nM
C=CC[n+]1ccc(CCC(=O)C2Cc3cc(OC)c(OC)cc3S2)cc1 CHEMBL189122 IC50 6.27 nM
O=[N+]([O-])OCCCCCCNCCCNc1c2c(nc3ccccc13)CCCC2 CHEMBL261384 IC50 6.3 nM
COc1nc(-c2ccnc(NC(=O)C3CC3)c2)sc1C(=O)NCCNc1c2c(nc3ccccc13)CCCC2 CHEMBL4286601 IC50 6.3 nM
N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCCCCCNc1c2c(nc3cc(Cl)ccc13)CCCC2 CHEMBL4556281 IC50 6.3 nM
CCOc1cc2c(cc1OCC)C(=O)C(C)C2 CHEMBL158242 -Log IC50 6.31 nM
CCOc1ccc(Cc2nc3cc(C(=O)N(CC)CC)ccc3n2CCCCCNc2c3c(nc4ccccc24)CCCC3)cc1 CHEMBL4583716 pIC50 6.31 nM
COc1ccc(-c2cc(=O)c3ccc(OCCN4CCC(C)CC4)cc3o2)cc1 CHEMBL5278007 IC50 6.33 nM
C/C=C1\C2C=C(C)C[C@]1(C(=O)OC)CC(NCCCCCCCNc1c3c(nc4ccccc14)CCCC3)C2 CHEMBL210453 Ki 6.4 nM
O=[N+]([O-])OCCCNCCCNc1c2c(nc3ccccc13)CCCC2 CHEMBL270491 IC50 6.4 nM
COc1nc(-c2ccnc(NC(=O)C3CC3)c2)sc1C(=O)NCCCNc1c2c(nc3ccccc13)CCCC2 CHEMBL4278686 IC50 6.4 nM
CC(C)=CCc1c(O)cc(O)c2c1O[C@H](c1ccccc1)CC2=O CHEMBL253998 IC50 6.4 nM
CC1=CC2Cc3nc4ccccc4c(NCCCCCCCCCCNc4c5c(nc6ccccc46)CCCC5)c3C(C1)C2 CHEMBL3600553 IC50 6.46 nM
CC(=O)c1ccccc1NC(=O)c1ccc(OCCCCC[n+]2cccc3ccccc32)cc1 CHEMBL2159662 Ki 6.47 nM
CCC(C)n1cc(C(=O)C(F)(F)F)cn1 CHEMBL3623549 IC50 6.47 nM
O=C(NCCCCCCCCCCNc1c2c(nc3ccccc13)CCCC2)c1cc(=O)c2cc(O)c(O)cc2o1 CHEMBL2019052 IC50 6.5 nM
CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)c(C(=O)NCCCCCC(=O)NNc2c3c(nc4cc(Cl)ccc24)CCCC3)cc1OCC[N+](CC)(CC)CC CHEMBL555247 IC50 6.54 nM
CCN(CCCCCC(=O)N1CCC(CCCC2CCN(C(=O)CCCCCN(CC)Cc3ccccc3OC)CC2)CC1)Cc1ccccc1OC CHEMBL222378 Log IC50 6.607 nM
O=C(NCCNc1c2c(nc3ccccc13)CCCC2)C(=O)NCCNc1c2c(nc3ccccc13)CCCC2 CHEMBL440983 IC50 6.65 nM
COc1cc(CCC(=O)/C=C/CCCNc2c3c(nc4cc(Cl)ccc24)CC2CC(C)=CC3C2)ccc1O CHEMBL3355579 IC50 6.7 nM
CC[N+](CC)(CC)CCOc1cc(OCC[N+](CC)(CC)CC)cc(C(=O)NCCCCCC(=O)NNc2c3c(nc4cc(Cl)ccc24)CCCC3)c1 CHEMBL540132 IC50 6.75 nM
O=C(NCCCCCNc1c2c(nc3ccccc13)CCCC2)[C@@H]1CCCN1CCNc1c2c(nc3ccccc13)CCCC2 CHEMBL451304 Ki 6.75 nM
CCC1=CC2Cc3nc4cc(Cl)ccc4c(NCCO)c3C(C1)C2 CHEMBL573095 IC50 6.75 nM
Cc1nc2ccc(C(=O)CCC3CCN(Cc4ccccc4)CC3)cc2s1 CHEMBL1084275 pIC50 6.761 nM
CNC(=O)Oc1cccc(CN(C)CCCCCCCCOc2ccc3c(=O)c4ccccc4oc3c2)c1 CHEMBL557405 IC50 6.8 nM
Cc1nc2ccc(C(=O)CCC3CCN(Cc4ccccc4)CC3)cc2s1 CHEMBL542543 IC50 6.8 nM
CNC(=O)Oc1cccc(CN(C)CCCCCCCCOc2ccc3c(=O)c4ccccc4oc3c2)c1 CHEMBL1085278 IC50 6.8 nM
COc1cc(-c2cc3c(c(=O)o2)C[C@]2(O)[C@@]4(C)C(=O)C=CC(C)(C)[C@]4(O)CC[C@@]2(C)O3)cc(OC)c1O CHEMBL3632858 IC50 6.8 nM
Cc1c(Cl)c(=O)oc2cc(OCCCCSC(=S)N3CCCCC3C)ccc12 CHEMBL5219522 IC50 6.8 nM
CC1=C[C@H]2Cc3nc4cc(Cl)ccc4c(NCCCCCCCNc4c5c(nc6ccccc46)CCCC5)c3[C@@H](C1)C2 CHEMBL3217208 IC50 6.84 nM
CNC(=O)Oc1cccc(CN(C)CCCOc2ccc3c(c2)O/C(=C\c2cccc4ccccc24)C3=O)c1 CHEMBL190060 IC50 6.86 nM
COc1cc2oc(-c3ccc(OCC(=O)NCCCCCNc4c5c(nc6cc(Cl)ccc46)CCCC5)cc3)cc(=O)c2c(OC)c1OC CHEMBL3403874 IC50 6.9 nM
N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCCCCCNc1c2c(nc3cc(Cl)ccc13)CCCC2 CHEMBL4449083 IC50 6.9 nM
CCCCCCCNC(=O)Oc1cccc(CN(C)CCCCCOc2ccc3c(c2)Oc2ncccc2C3)c1 CHEMBL3827044 IC50 6.92 nM
O=C(CCCCC1CCSS1)NCCCNc1c2c(nc3ccccc13)CCCC2 CHEMBL195179 IC50 6.96 nM
COc1cc2c(cc1OCc1ccccc1)CCC(C)(CC(=O)NCCCCCCCNc1c3c(nc4cc(Cl)ccc14)CCCC3)O2 CHEMBL4747041 IC50 6.99 nM
CCOCC[n+]1ccc(CCC(=O)c2cc3cc(OC)c(OC)cc3s2)cc1 CHEMBL87441 IC50 7.0 nM
CCOCC[n+]1ccc(CCC(=O)C2Cc3cc(OC)c(OC)cc3S2)cc1 CHEMBL186264 IC50 7.0 nM
CCOC(=O)C1=CN(C)c2cccc(OC(=O)N(C)C)c2C1 CHEMBL1243360 IC50 7.0 nM
CC(C)(C)c1cc[n+](CCCCCCCCCCCC[n+]2ccc(C(C)(C)C)cc2)cc1 CHEMBL594629 IC50 7.0 nM
CC(C)C1=N[C@H]2CC[C@]34C[C@]35C(=O)C[C@]3(C)[C@@H]([C@H](C)N(C)Cc6ccccc6)[C@H](O)C[C@@]3(C)[C@@H]5CC[C@H]4[C@]2(C)CS1 CHEMBL1783525 IC50 7.0 nM
CC[N+]1(Cc2ccccc2[N+](=O)[O-])CCCCCn2c(C)cc(=O)n(c2=O)CCCCC[N+](CC)(Cc2ccccc2[N+](=O)[O-])Cc2ccc(cc2)C1 CHEMBL3621333 IC50 7.0 nM
CC(=O)NCCc1c[nH]c2ccc(OC(=O)NCCCCCCCCCCCCNc3c4c(nc5ccc(Cl)cc35)CCCC4)cc12 CHEMBL3642057 IC50 7.0 nM
CCOC(=O)c1cc2c(OC(=O)N(C)C)cccc2[n+](C)c1 CHEMBL5219352 IC50 7.0 nM
CC[N+](CC)(CCCCCn1c(=O)cc(C)n(CCCn2c(C)cc(=O)n(C)c2=O)c1=O)Cc1ccccc1[N+](=O)[O-] CHEMBL5396497 IC50 7.0 nM
O=C(NCCCCCCCCNc1c2c(nc3cc(Cl)ccc13)CCCC2)c1ccc2nc(-c3ccc(Cl)cc3)c3c(c2c1)OCCC3 CHEMBL1196204 IC50 7.03 nM
Cc1cccc2c1CC(C)C2=O CHEMBL352247 -Log IC50 7.079 nM
COc1cccc2c(CCC3CCN(Cc4ccccc4)CC3)noc12 CHEMBL93619 Log Ki 7.079 nM
CCCC(C)n1cc(C(=O)C(F)(F)F)cn1 CHEMBL3623550 IC50 7.15 nM
CCN(Cc1ccccc1)Cc1ccc(-c2cc3cc(OCCNC(=O)/C=C/c4cc(F)cc(F)c4)ccc3oc2=O)cc1 CHEMBL239046 IC50 7.16 nM
COc1ccc(-c2oc3cc(OC)c(I)cc3c(=O)c2O)cc1 CHEMBL5278429 IC50 7.19 nM
COc1ccc2onc(CCC3CCN(Cc4ccccc4)CC3)c2c1 CHEMBL94186 Log IC50(nM) 7.194 nM
Oc1ccc([C@@H]2CC(c3c4ccccc4cc4ccccc34)=NN2)c(O)c1 CHEMBL2312573 Ki 7.2 nM
NC(Cc1c[nH]c2ccccc12)C(=O)NCCCCCCNc1c2c(nc3cc(Cl)ccc13)CCCC2 CHEMBL4559593 IC50 7.4 nM
CCN(CCCCCC(=O)N1CCC(CCC2CCN(C(=O)CCCCCN(CC)Cc3ccccc3OC)CC2)CC1)Cc1ccccc1OC CHEMBL387394 Log IC50 7.413 nM
Cc1cc(CCNc2c3c(nc4ccccc24)CCCC3)cc(CCNc2c3c(nc4ccccc24)CCCC3)c1 CHEMBL507438 Ki 7.45 nM
COc1ccc(-c2cc(=O)c3ccc(OCCN4CCN(CCO)CC4)cc3o2)cc1 CHEMBL5273737 IC50 7.56 nM
CC1=CC2Cc3nc4cc(Cl)ccc4c(NCCCCCCCCCCNC(=O)c4cc(O)c5c(c4)C(=O)c4cccc(O)c4C5=O)c3C(C1)C2 CHEMBL3303094 IC50 7.6 nM
CC[N+](CC)(CC)CCOc1ccc(C(=O)NCCCCCC(=O)NNc2c3c(nc4ccccc24)CCCC3)cc1 CHEMBL1203985 IC50 7.61 nM
CC1=CC2Cc3nc4cc(Cl)ccc4c(NCCCCCCCCCCNC(=O)c4cc(O)c5c(c4)C(=O)c4cccc(O)c4C5=O)c3C(C1)C2 CHEMBL3234038 IC50 7.61 nM
O=C(CNCc1cc(F)cc(F)c1)Nc1ccc2nc3n(c(=O)c2c1)CCC3 CHEMBL4207101 IC50 7.61 nM
CN1CCC(C[C@H]2Cc3ccccc3C2=O)CC1 CHEMBL345905 IC50 7.7 nM
CCN(CCCCCCn1c(=O)c2cc3c(=O)n(CCCCCCN(CC)Cc4ccccc4OC)c(=O)c3cc2c1=O)Cc1ccccc1OC CHEMBL507903 IC50 7.7 nM
CC(=O)NCCc1c[nH]c2ccc(OC(=O)NCCCCCCCNc3c4c(nc5cc(Cl)ccc35)CCCC4)cc12 CHEMBL3642043 IC50 7.7 nM
Cc1ccc2onc(CCC3CCN(Cc4ccccc4)CC3)c2c1 CHEMBL433379 Log Ki 7.762 nM
CCN(CCCCCCCNC1=CC(=O)C(NCCCCCCCN(CC)Cc2ccccc2OC)=CC1=O)Cc1ccccc1OC CHEMBL243273 IC50 7.79 nM
COc1cc2c(cc1OCc1ccccc1)CCC(C)(CC(=O)NCCCCCCCCCNc1c3c(nc4cc(Cl)ccc14)CCCC3)O2 CHEMBL4789620 IC50 7.89 nM
COc1cc2c(cc1O)CCC(C)(CCC(=O)NCCCCCCCNc1c3c(nc4cc(Cl)ccc14)CCCC3)O2 CHEMBL4797177 IC50 7.94 nM
COc1cc2cc(C(=O)C3CCC[N+](C)(Cc4ccccc4)CC3)sc2cc1OC CHEMBL186144 Log Ki 7.943 nM
CCOc1ccc(Cc2nc3cc(C(=O)NCCCCCNc4c5c(nc6ccccc46)CCCC5)ccc3n2CCC(C)C)cc1 CHEMBL4453905 pIC50 7.943 nM
C=CC[N+](C)(C)c1ccc(CCC(=O)CCc2ccc([N+](C)(C)CC=C)cc2)cc1 CHEMBL140020 pIC50 7.998 nM
COc1cc2cc(C(=O)CCC3CC[N+](C)(Cc4ccccc4)CC3)sc2cc1OC CHEMBL88026 IC50 8.0 nM
COc1cc2cc(C(=O)CCC3CC[N+](C)(Cc4ccccc4)CC3)sc2cc1OC CHEMBL87273 IC50 8.0 nM
COc1ccc2c(c1OC)C(=O)CC2CCC1CCN(Cc2ccccc2)CC1 CHEMBL1083065 IC50 8.0 nM
COc1ccc2c(c1)C(=O)N(CCC1CCN(Cc3ccccc3)CC1)C2=O CHEMBL140770 IC50 8.0 nM
CNC(=O)Oc1cccc(CN(C)CCCCCCCOc2ccc3c(c2)O/C(=C\c2ccc(Cl)c(Cl)c2)C3=O)c1 CHEMBL372710 IC50 8.0 nM
O=C(NCCCCCCCCCCNc1c2c(nc3ccccc13)CCCC2)c1cc(=O)c2cc(O)ccc2o1 CHEMBL2019043 IC50 8.0 nM
CCOC(=O)c1c(C)nc(N2CCN(S(=O)(=O)c3ccc(NC(C)=O)c(Cl)c3)CC2)nc1-c1ccc(OC)c(OC)c1 CHEMBL4790766 Ki 8.0 nM
Clc1ccc2c(NCCCCCN3c4ccccc4Sc4ccccc43)c3c(nc2c1)CCCC3 CHEMBL5412564 IC50 8.0 nM
CC(=O)NCCc1c[nH]c2ccc(OC(=O)NCCCCCCCCCCNc3c4c(nc5cc(Cl)ccc35)CCCC4)cc12 CHEMBL3642055 IC50 8.1 nM
CNC(=O)Oc1cccc2c1SCC1CCN(C)C21 CHEMBL190322 IC50 8.11 nM
CNC(=O)Oc1ccc2c(c1)SC[C@@H]1CCN(C)[C@H]21 CHEMBL1243329 IC50 8.11 nM
CC[N+](C)(CCCCCC(=O)N(CCCCCCCCN(C(=O)CCCCC[N+](C)(CC)Cc1ccccc1OC)C(C)C)C(C)C)Cc1ccccc1OC CHEMBL176521 pIC50 8.128 nM
COc1ccc2c(CCC3CCN(Cc4ccccc4)CC3)noc2c1 CHEMBL418955 Log IC50(nM) 8.299 nM
Nc1c2c(nc3cc(Cl)ccc13)CCCC2 CHEMBL486698 IC50 8.32 nM
COc1cc2c(cc1O)CCC(C)(CCNCCOCCOCCNc1c3c(nc4cc(Cl)ccc14)CCCC3)O2 CHEMBL4787251 IC50 8.35 nM
COc1cc(CCC(=O)NCCCCCC(=O)NNc2c3c(nc4ccccc24)CCCC3)cc(OC)c1OC CHEMBL219264 IC50 8.39 nM
CN1CCC(/C=C2\Cc3ccccc3C2=O)CC1 CHEMBL156874 IC50 8.4 nM
COc1ccccc1NC(=O)C1CCN(C(=O)c2ccccc2)CC1 CHEMBL5266286 IC50 8.46 nM
COc1cc(N)c(Cl)cc1C(=O)CCC1CCN(Cc2ccccc2)CC1 CHEMBL3417001 IC50 8.5 nM
CCCCNC(=O)Oc1cccc(CN(CC)CCCOc2ccc3c(=O)c4ccccc4oc3c2)c1 CHEMBL339039 IC50 8.6 nM
COc1ccc(/C=C/C(=O)Nc2cc[n+](Cc3ccc(F)cc3)cc2)cc1OC CHEMBL5206601 IC50 8.6 nM
CC1=CC2Cc3nc4cc(Cl)ccc4c(NCCN=[N+]=[N-])c3C(C1)C2 CHEMBL574973 IC50 8.69 nM
O=C(CCC1CCN(Cc2cccc(O)c2)CC1)c1cc2c3c(ccn3C(=O)CC2)c1 CHEMBL1651140 pIC50 8.71 nM
Nc1ccc2c(c1)C(=O)N(CCC1CCN(Cc3ccccc3)CC1)C2=O CHEMBL139353 IC50 8.8 nM
c1ccc2c(NCCCCCCCCNc3c4c(nc5ccccc35)CCCC4)ccnc2c1 CHEMBL1082738 IC50 8.8 nM
COc1cc2c(cc1OC)C(=O)C(Cc1cc[n+](Cc3ccccc3C)cc1C(C)=O)C2 CHEMBL4081915 IC50 8.8 nM
CC1CCN(CC2CCCCC2)CC1 CHEMBL345241 IC50 8.9 nM
CCCCNC(=O)Oc1cccc(CN(C)CCCOc2ccc3c(=O)c4cccnc4oc3c2)c1 CHEMBL130918 IC50 8.9 nM
CNC(=O)Oc1cccc(CN(C)CCCOc2ccc3c(=O)ccoc3c2)c1 CHEMBL128618 IC50 8.9 nM
CN(CCCOc1ccc2c(=O)c3ccccc3oc2c1)Cc1cccc(OC(=O)NCCCCCCCCCN2CCOCC2)c1 CHEMBL127857 IC50 8.9 nM
COc1cc2c(cc1OC(C)C)CC(C)C2=O CHEMBL153848 -Log IC50 8.913 nM
O=C1C(Cl)=C(NCCCNc2c3c(nc4cc(Cl)ccc24)CCCC3)C(=O)c2ccccc21 CHEMBL3356952 IC50 8.94 nM
CN(C)C(=O)Oc1cccc2c1CCC2N CHEMBL554452 IC50 9.0 nM
c1ccc(CN2CCC(CCCc3noc4ccccc34)CC2)cc1 CHEMBL93241 IC50 9.0 nM
O=C1c2cccc([N+](=O)[O-])c2C(=O)N1CCC1CCN(Cc2ccccc2)CC1 CHEMBL141001 IC50 9.0 nM
CN(C)CC(C)(C)c1cccc(OC(=O)NCCCCN2CCOCC2)c1 CHEMBL1782707 IC50 9.0 nM
COc1ccc(CN(C)[C@@H](C)[C@H]2[C@H](O)C[C@@]3(C)[C@@H]4CC[C@H]5[C@]6(C)CSC(C(C)C)=N[C@H]6CC[C@@]56C[C@@]46C(=O)C[C@]23C)cc1 CHEMBL1783515 IC50 9.0 nM
COc1cc2c(cc1OC)C(=O)C(CC1CCN(CC3CCCCC3)CC1)C2 CHEMBL355160 IC50 9.0 nM
CC(=O)Nc1cc(C(=O)Nc2cncc(OCC3CCN(Cc4ccc(F)cc4)CC3)c2)ccn1 CHEMBL4875903 IC50 9.0 nM
CC1=CC2Cc3nc4cc(Cl)ccc4c(NCCCCCCCCCCNc4c5c(nc6cc(Cl)ccc46)CCCC5)c3C(C1)C2 CHEMBL3216779 IC50 9.09 nM
O=C1C(NCCCNc2c3c(nc4cc(Cl)ccc24)CCCC3)=CC(=O)c2c(O)cccc21 CHEMBL3356537 IC50 9.24 nM
Nc1c2c(nc3cccc(Cl)c13)CCCC2 CHEMBL134057 Log IC50 9.333 nM
O=C(Nc1ccc2c(CCC3CCN(Cc4ccccc4)CC3)noc2c1)c1ccccc1 CHEMBL93123 Log Ki 9.333 nM
COc1cc(O)c(C(=O)/C=C/c2ccc(F)cc2)cc1I CHEMBL5275941 IC50 9.38 nM
N#Cc1cc(C#N)c(NCCCC2CCN(Cc3ccccc3)CC2)nc1N CHEMBL2088785 IC50 9.4 nM
CC(=O)c1ccccc1NC(=O)c1ccc(OCCCCCC[n+]2ccc3ccccc3c2)cc1 CHEMBL2159661 Ki 9.4 nM
C#CCNc1c2c(nc3cc(Cl)ccc13)CCCC2 CHEMBL4632951 IC50 9.4 nM
CCN(CCCCCCNC1=C(C)C(=O)C(NCCCCCCN(CC)Cc2ccccc2OC)=C(C)C1=O)Cc1ccccc1OC CHEMBL243269 IC50 9.5 nM
O=C(Nc1cc(-c2cn(CCNc3c4c(nc5ccccc35)CCCC4)nn2)ccn1)Nc1cccc2c1[C@H]1CCCCN1C2=O CHEMBL4443989 IC50 9.5 nM
C#CCOc1cccc(-c2cc(-c3ccc(OCCN4CCOCC4)cc3)nc(C)n2)c1 CHEMBL5199704 IC50 9.54 nM
Cc1ccc(F)cc1 CHEMBL346605 -Log IC50 9.55 nM
Cc1ccccc1F CHEMBL352215 -Log IC50 9.55 nM
O=C(CCc1ccc2nc(-c3ccccc3)c3c(c2c1)OCCC3)NCCCCCNc1c2c(nc3cc(Cl)ccc13)CCCC2 CHEMBL2448076 IC50 9.64 nM
CC1=CC2Cc3nc4cc(Cl)ccc4c(NCCO)c3C(C1)C2 CHEMBL583920 IC50 9.66 nM
O=S(=O)(c1ccccc1)n1ccc2c(N3CCN(CCCNc4c5c(nc6ccccc46)CCCC5)CC3)cccc21 CHEMBL3884618 IC50 9.7 nM
CCN(CCCCCCNC1=CC(=O)c2ccccc2C1=O)Cc1ccccc1OC CHEMBL1940612 IC50 9.73 nM
O=C(CCN1CCC2c3ccccc3NC2C1)Nc1ccc(/C=C2\CCn3c2nc2ccccc2c3=O)cc1 CHEMBL4757466 IC50 9.75 nM
O=C(CCC1CCN(Cc2ccccc2)CC1)c1cc2c3c(c1)CCN3C(=O)CC2 CHEMBL1651130 pIC50 9.772 nM
COc1ccc(NC(=O)C2CCN(C(=O)c3ccccc3)CC2)cc1 CHEMBL5268019 IC50 9.78 nM
CNC(=O)Oc1cccc(CN(C)CCCCCCCOc2ccc3c(c2)OC/C(=C/c2cc(O)c(O)c(O)c2)C3=O)c1 CHEMBL1085939 IC50 9.81 nM