COC(=O)N1C[C@@H](C)N(c2ncc3[nH]nc(-c4ccc(N5CCN[C@H](C)C5)nc4)c3n2)[C@@H](C)C1 CHEMBL5184000 IC50 0.85 nM
COC(=O)N1C[C@@H](C)N(c2ncc3[nH]nc(-c4ccc(N5CCN(C)CC5)cc4)c3n2)[C@@H](C)C1 CHEMBL5181536 IC50 0.98 nM
CN1CCN(c2ccc(-c3ccn4c(-c5csc6nccnc56)cnc4c3)cc2)CC1 CHEMBL4790396 IC50 1.0 nM
COc1cc(-c2cc(-c3cccc(O)c3)cnc2N)cc(OC)c1OC CHEMBL1230714 IC50 1.1 nM
O=C(Nc1cc(Nc2c(Cl)cnc3c2OCO3)ccn1)C1CC1 CHEMBL3818173 IC50 1.2 nM
C[C@@H]1CN(c2ccc(-c3n[nH]c4cnc(N5[C@H](C)CN(C(=O)N6CCCC6)C[C@@H]5C)nc34)cn2)CCN1 CHEMBL5199417 IC50 1.2 nM
COC(=O)N1C[C@@H](C)N(c2ncc3[nH]nc(-c4ccc(N5CCN(C)CC5)nc4)c3n2)[C@@H](C)C1 CHEMBL5186341 IC50 1.3 nM
COC(=O)N1C[C@@H](C)N(c2ncc3[nH]nc(-c4ccc(N5CCN(C)CC5)c(F)c4)c3n2)[C@@H](C)C1 CHEMBL5181872 IC50 1.3 nM
CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)cc1 CHEMBL49120 pKi 1.585 nM
C[C@@H]1CN(c2ccc(-c3n[nH]c4cnc(N5[C@H](C)CCC[C@@H]5C)nc34)cn2)CCN1 CHEMBL5171699 IC50 2.5 nM
CN1CCC(n2cc(-c3cnc(N)c4c3CCN(C3CCCCC3)C4=O)cn2)CC1 CHEMBL5200241 IC50 2.9 nM
COc1cc(-c2cncc(-c3ccc(N4CCN(C)CC4)cc3)c2C)cc(F)c1C(N)=O CHEMBL4575655 IC50 3.0 nM
COc1cc(-c2cncc(-c3ccc(N4C[C@@H](C)N(C)[C@@H](C)C4)cc3)c2C)cc(OC)c1C(N)=O CHEMBL4526828 IC50 3.0 nM
COc1cc(-c2cncc(-c3ccc(N4CCN(C(C)C)CC4)cc3)c2C)cc(F)c1C(N)=O CHEMBL4548795 IC50 3.0 nM
COc1cc(-c2cncc(-c3ccc(N4CCNCC4)cc3)c2C#N)cc(OC)c1OC CHEMBL4638273 IC50 3.0 nM
COc1cc(-c2ccc3c(c2)Nc2ccc(C(=O)NCCCN(C)C)cc2NC3=O)ccc1O CHEMBL1996702 pKi 3.162 nM
Nc1ncc(-c2cnn(C3CCNCC3)c2)c2c1C(=O)N(C1CCCCC1)CC2 CHEMBL5186575 IC50 3.2 nM
c1ccc2c(-c3cnn4cc(-c5ccc(N6CCNCC6)cc5)cnc34)ccnc2c1 CHEMBL513147 IC50 3.26 nM
Nc1ncc(-c2cnn(C3CCCNC3)c2)c2c1C(=O)N(C1CCCCC1)CC2 CHEMBL5205781 IC50 3.5 nM
C[C@@H]1CCCN1Cc1ccc(-c2cnc(N)c(C(=O)N[C@H]3CC[C@](C)(O)CC3)c2)cc1F CHEMBL5205791 IC50 3.6 nM
CC(C)n1nc(-c2cc3cc(O)ccc3[nH]2)c2c(N)ncnc21 CHEMBL1241674 Kd 4.0 nM
CN1CCN(CCOc2cc(OC3CCOCC3)c3c(Nc4c(Cl)ccc5c4OCO5)ncnc3c2)CC1 CHEMBL217092 Kd apparent 4.0 nM
COc1cc(-c2cncc(-c3ccc(N4CCNCC4)cc3)c2C)cc(F)c1C(N)=O CHEMBL4440168 IC50 4.0 nM
COc1cc(-c2cncc(-c3ccc(N4CCN(C)CC4)cc3)c2C)cc(OC)c1C(N)=O CHEMBL4435320 IC50 4.0 nM
COc1cc(-c2cncc(-c3ccc(N4CCNCC4)cc3)c2C)cc(Cl)c1C(N)=O CHEMBL4434694 IC50 4.0 nM
COc1cc(-c2cncc(-c3ccc(N4CCN(C(=O)N(C)C)CC4)cc3)c2C)cc(OC)c1OC CHEMBL4641207 IC50 4.0 nM
CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4ccccc4)c(=O)n(CC)c3n2)cc1 CHEMBL136106 IC50 4.0 nM
Nc1ncc(-c2cnn(CC3CCNCC3)c2)c2c1C(=O)N(C1CCCCC1)CC2 CHEMBL5189461 IC50 4.4 nM
CCOC(=O)N1C[C@@H](C)N(c2ncc3[nH]nc(-c4ccc(N5CCN[C@H](C)C5)nc4)c3n2)[C@@H](C)C1 CHEMBL5188971 IC50 4.9 nM
CC(C)c1cc(CNc2nc(Nc3cc(C4CC4)[nH]n3)cc(N3CCN(C)CC3)n2)on1 CHEMBL3545085 Kd apparent 5.0 nM
COc1cc(-c2cncc(-c3ccc(N4CCNCC4)cc3)c2C)cc(OC)c1C(N)=O CHEMBL4565968 IC50 5.0 nM
COc1cc(-c2cncc(-c3ccc(N4CCN(C(C)C)CC4)cc3)c2C)cc(OC)c1C(N)=O CHEMBL4468389 IC50 5.0 nM
COc1cc(-c2cncc(-c3ccc(N4CCNCC4)cc3)c2C)ccc1C(N)=O CHEMBL4553210 IC50 5.0 nM
COc1cc(-c2cncc(-c3ccc(C4=CCNCC4)cc3)c2C)cc(OC)c1OC CHEMBL4641530 IC50 5.0 nM
COc1cc(NS(C)(=O)=O)cc(-c2cc(-c3ccc(N4CCNCC4)cc3)cnc2N)c1 CHEMBL4784430 IC50 5.0 nM
COc1cc(NS(=O)(=O)c2ccccc2)cc(-c2cc(-c3ccc(N4CCNCC4)cc3)cnc2N)c1 CHEMBL4776631 IC50 5.0 nM
Nc1ncc(-c2cnn(C3CCNCC3)c2)c2c1C(=O)N(C1C3CC4CC(C3)CC1C4)CC2 CHEMBL5175201 IC50 5.3 nM
Cc1cc(-c2cnc3cc(-c4ccc(C5COCCN5)cc4)ccn23)c2cc(F)cc(F)c2n1 CHEMBL4753476 IC50 5.6 nM
COc1cc(-c2cc(-c3cccc(NS(C)(=O)=O)c3)cnc2N)cc(OC)c1OC CHEMBL3341943 IC50 6.0 nM
COc1cc(-c2cncc(-c3ccc(OC4CCNCC4)cc3)c2C)cc(OC)c1OC CHEMBL4648102 IC50 6.0 nM
COc1cc(-c2cncc(-c3ccc(OC4CCN(C)CC4)cc3)c2C)cc(OC)c1OC CHEMBL4647724 IC50 6.0 nM
COc1cc(-c2cncc(-c3ccc(N4CCNCC4)cc3)c2C)cc(OC)c1OC CHEMBL4517408 IC50 6.0 nM
c1ccc2c(-c3coc4cc(-c5ccc(N6CCNCC6)cc5)cnc34)ccnc2c1 CHEMBL5083143 IC50 6.0 nM
Cc1cc(-c2cnc3cc(-c4ccc(N5CCN(C(C)C)CC5)nc4)ccn23)c2ccccc2n1 CHEMBL4741939 IC50 6.3 nM
C[C@@H]1CN(c2ccc(-c3n[nH]c4cnc(N5[C@H](C)CN(C(=O)N(C)C)C[C@@H]5C)nc34)cn2)CCN1 CHEMBL5202554 IC50 6.4 nM
Nc1ncc(-c2cnn(CC3CCCNC3)c2)c2c1C(=O)N(C1CCCCC1)CC2 CHEMBL5195236 IC50 6.5 nM
Cc1cc2cn[nH]c2cc1-c1cccc2c(N)c(C(N)=O)nnc12 CHEMBL3586447 IC50 7.0 nM
COc1cc(-c2cncc(-c3ccc(N4CCN(C(C)C)CC4)cc3)c2C)cc(OC)c1OC CHEMBL4644571 IC50 7.0 nM
COc1cc(-c2cncc(-c3ccc(C4CCN(C)CC4)cc3)c2C)cc(OC)c1OC CHEMBL4633241 IC50 7.0 nM
COCC(=O)N1C[C@@H](C)N(c2ncc3[nH]nc(-c4ccc(N5CCN[C@H](C)C5)nc4)c3n2)[C@@H](C)C1 CHEMBL5204620 IC50 7.3 nM
N#CCNC(=O)c1ccc(-c2ccnc(Nc3ccc(N4CCOCC4)cc3)n2)cc1 CHEMBL1078178 IC50 8.0 nM
COc1cc(-c2cncc(-c3ccc(N4C[C@@H](C)N[C@@H](C)C4)cc3)c2C)cc(OC)c1OC CHEMBL4634857 IC50 8.0 nM
Cc1cc(-c2cnc3cc(-c4ccc(N5CCNCC5)cc4)ccn23)c2ccccc2n1 CHEMBL4740381 IC50 8.0 nM
CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(Cc4ccccc4)c3n2)cc1 CHEMBL4858463 IC50 8.0 nM
Nc1ncc(-c2ccc(CN3CCC(N4CCOCC4)CC3)cc2Cl)nc1C(=O)NC12CCC(O)(CC1)CC2 CHEMBL5193039 IC50 8.0 nM
CC(C)C(=O)N1C[C@@H](C)N(c2ncc3[nH]nc(-c4ccc(N5CCN[C@H](C)C5)nc4)c3n2)[C@@H](C)C1 CHEMBL5173868 IC50 8.0 nM
CC1CCCCN1c1ncc2[nH]nc(-c3ccc(N4CCN[C@H](C)C4)nc3)c2n1 CHEMBL5178082 IC50 8.1 nM
C[C@@H]1CNC[C@H](C)N1c1ccc(-c2cnc3c(-c4ccnc5ccccc45)cnn3c2)cc1 CHEMBL4280599 IC50 9.0 nM
CC(c1ccc(-c2cnc3c(-c4ccc(S(N)(=O)=O)c5ccccc45)cnn3c2)cc1)N1CCCC1 CHEMBL4283638 IC50 9.0 nM
COc1cc(-c2cncc(-c3ccc(N4CCN(C)CC4)cc3)c2C)cc(OC)c1OC CHEMBL4643265 IC50 9.0 nM
COc1cc(-c2cncc(-c3ccc(C4CCNCC4)cc3)c2C)cc(OC)c1OC CHEMBL4635321 IC50 9.0 nM
CCCS(=O)(=O)Nc1cc(OC)cc(-c2cc(-c3ccc(N4CCNCC4)cc3)cnc2N)c1 CHEMBL4800115 IC50 9.0 nM
CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(CC(C)C)c3n2)cc1 CHEMBL4847211 IC50 9.0 nM
COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 CHEMBL509032 pKi 10.0 nM
COc1cc(-c2cc(-c3ccc(N4CCNCC4)cc3)cnc2N)cc(OC)c1OC CHEMBL3341945 IC50 10.0 nM
COc1cc(-c2cnn3cc(-c4ccc(N5CCNCC5)cc4)cnc23)cc(OC)c1OC CHEMBL3341794 IC50 10.0 nM
Cc1cc2ccc(-c3ccnc4ccccc34)c(C)c2c(=O)[nH]1 CHEMBL4241942 IC50 10.0 nM
COc1cc(-c2cncc(-c3ccc(N4C[C@@H](C)N(C)[C@@H](C)C4)cc3)c2C)cc(F)c1C(N)=O CHEMBL4434717 IC50 10.0 nM
CN(C)Cc1ccc(-c2cnc(N)c(C(=O)NC3CCCCC3)n2)cc1 CHEMBL5182576 IC50 10.0 nM
CN1CCN(c2ccc(-c3ccn4c(-c5cccc6ncsc56)cnc4c3)cc2)CC1 CHEMBL4788637 IC50 10.4 nM
Cc1cc(-c2cnc3cc(-c4ccc(N5CCNCC5)cc4)ccn23)c2cc(F)ccc2n1 CHEMBL4788859 IC50 10.9 nM
COc1cc(-c2cncc(-c3ccc(N4CCNCC4)cc3)c2C#N)cc(OC)c1F CHEMBL4646278 IC50 11.0 nM
COc1cc(NS(=O)(=O)C(C)C)cc(-c2cc(-c3ccc(N4CCNCC4)cc3)cnc2N)c1 CHEMBL4781705 IC50 11.0 nM
CC(C)N1CCN(Cc2ccc(-c3cnc(N)c(C(=O)N[C@H]4CC[C@H](O)CC4)n3)cc2)CC1 CHEMBL5189710 IC50 11.0 nM
Nc1ncc(-c2cnn(C3CCNCC3)c2)c2c1C(=O)N(C1CCC1)CC2 CHEMBL5197985 IC50 11.0 nM
COc1cc(-c2cncc(-c3ccc(N4CCCNCC4)cc3)c2C)cc(OC)c1OC CHEMBL4639700 IC50 13.0 nM
C[C@@H]1CCCN1Cc1ccc(-c2cnc(N)c3c2CCN(C2CCCCC2)C3=O)cc1 CHEMBL5172921 IC50 13.0 nM
COc1cc(OC)cc(-c2cc(-c3ccc(N4CCNCC4)cc3)cnc2N)c1 CHEMBL3341947 IC50 14.0 nM
COc1cc(-c2cncc(-c3ccc(C4=CCN(C)CC4)cc3)c2C)cc(OC)c1OC CHEMBL4646444 IC50 14.0 nM
CN1CCN(c2ccc(-c3ccn4c(-c5ccnc6ccsc56)cnc4c3)cc2)CC1 CHEMBL4754026 IC50 14.0 nM
Cc1cc(-c2cnc3cc(-c4ccc(N5CCN[C@H](C)C5)nc4)ccn23)c2cc(F)ccc2n1 CHEMBL4757577 IC50 14.7 nM
COc1cc(-c2cncc(-c3ccc(N4CCNCC4)cc3)c2)cc(OC)c1OC CHEMBL3341787 IC50 15.0 nM
COc1cc(-c2cncc(-c3ccc(N4CCNCC4)cc3)c2F)cc(OC)c1OC CHEMBL4633121 IC50 15.0 nM
CN1CCN(c2ccc(-c3ccn4c(-c5ccnc6ccc(F)cc56)cnc4c3)cc2)CC1 CHEMBL4795028 IC50 15.0 nM
Cc1cc(-c2cnc3cc(-c4ccc(N5CCN(C6CC6)CC5)nc4)ccn23)c2ccccc2n1 CHEMBL4797386 IC50 15.6 nM
COc1cc(-c2ccc3c(c2)Nc2c(O)cccc2NC3=O)ccc1O CHEMBL550418 pKi 15.85 nM
NC1(c2ccc(-c3cnc4c(-c5ccc(S(N)(=O)=O)c6ccccc56)cnn4c3)cc2)CCC1 CHEMBL4278763 IC50 16.0 nM
COc1cc(-c2cncc(-c3ccc(N4CCNCC4)cc3)c2Cl)cc(OC)c1OC CHEMBL4642165 IC50 16.0 nM
COc1cc(-c2cncc(-c3ccc(N4CCS(=O)(=O)CC4)cc3)c2C)cc(OC)c1OC CHEMBL4648735 IC50 16.0 nM
COc1cc(-c2cc(-c3cccc(N4CCNCC4)c3)cnc2N)cc(OC)c1OC CHEMBL3341944 IC50 17.0 nM
COc1cc(-c2cncc(-c3ccc(N4CCN(CCF)CC4)cc3)c2C)cc(OC)c1OC CHEMBL4647991 IC50 17.0 nM
CCN(CC)C1CCN(Cc2ccc(-c3cnc(N)c(C(=O)N[C@H]4CC[C@H](O)CC4)n3)cc2)CC1 CHEMBL5206645 IC50 17.0 nM
Nc1ncc(-c2ccc(CN3CCC(N4CCCC4)CC3)cc2)nc1C(=O)N[C@H]1CC[C@H](O)CC1 CHEMBL5200388 IC50 17.0 nM
CC(=O)N1CCC(n2cc(-c3cnc(N)c4c3CCN(C3CCCCC3)C4=O)cn2)CC1 CHEMBL5178564 IC50 17.0 nM
Cc1cc(-c2cnc3cc(-c4ccc(N5CCN(C)CC5)cc4)ccn23)c2cc(F)ccc2n1 CHEMBL4759531 IC50 17.3 nM
Cc1cc(-c2cnc3cc(-c4ccc(N5CCN(C)CC5)cc4)ccn23)c2cc(F)cc(F)c2n1 CHEMBL4792932 IC50 17.8 nM
CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4ccccc4)c(=O)n(CCO)c3n2)cc1 CHEMBL4871544 IC50 18.0 nM
CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(CCOC)c3n2)cc1 CHEMBL4859716 IC50 18.0 nM
COCCN1CCN(c2ccc(Nc3nccc(-c4c(-c5cccnc5)nn5c4COCC5)n3)cc2)CC1 CHEMBL4748071 IC50 18.2 nM
C[C@@H]1CNC[C@H](C)N1c1ccc(-c2cnc3c(-c4ccc(S(N)(=O)=O)c5ccccc45)cnn3c2)cc1 CHEMBL4288921 IC50 19.0 nM
COc1cc(-c2cncc(-c3ccc(N4CCNCC4)cc3)c2C)cc(OC)c1F CHEMBL4636120 IC50 19.0 nM
Nc1ncc(-c2ccc(CN3CCC(N4CCOCC4)CC3)cc2)nc1C(=O)N[C@H]1CC[C@H](O)CC1 CHEMBL5199857 IC50 19.0 nM
Nc1ncc(-c2ccc(CN3CCC(N4CCOCC4)CC3)cc2Cl)nc1C(=O)N[C@H]1CC[C@H](O)CC1 CHEMBL5204737 IC50 19.0 nM
COc1cc(-c2cncc(-c3ccc(CN4CCN(C)CC4)cc3)c2C)cc(OC)c1OC CHEMBL4638893 IC50 20.0 nM
Nc1ncc(-c2cnn(C3COC3)c2)c2c1C(=O)N(C1CCCCC1)CC2 CHEMBL5207070 IC50 21.0 nM
CC1(O)CCC(N2CCc3c(-c4cnn(C5CCNCC5)c4)cnc(N)c3C2=O)CC1 CHEMBL5196379 IC50 21.0 nM
c1cncc(-c2nn3c(c2-c2ccnc(Nc4ccc(N5CCNCC5)cc4)n2)COCC3)c1 CHEMBL4744674 IC50 21.7 nM
C1=N/C2=N/c3ccc(OCCN4CCCC4)c(c3)COC/C=C/COCc3cccc(c3)C(=C1)N2 CHEMBL2035187 Kd apparent 22.0 nM
COc1cc(-c2cncc(-c3ccc(N4CCN(C(C)=O)CC4)cc3)c2C)cc(OC)c1OC CHEMBL4648707 IC50 22.0 nM
CN(C)Cc1ccc(-c2cnc(N)c(C(=O)NC3CCC(O)CC3)n2)cc1 CHEMBL5206178 IC50 22.0 nM
Nc1ncc(-c2cnn(C3CCCC3)c2)c2c1C(=O)N(C1CCCCC1)CC2 CHEMBL5189688 IC50 22.0 nM
COc1ccc(-c2cc(-c3ccc(N4CCNCC4)cc3)cnc2N)cc1OC CHEMBL3341946 IC50 23.0 nM
C[C@@H]1CN(c2ccc(-c3n[nH]c4cnc(N5[C@H](C)COC[C@@H]5C)nc34)cn2)CCN1 CHEMBL5177582 IC50 23.0 nM
COc1cc(-c2cc(-c3ccc(N4CCNCC4)cc3)cnc2C)cc(OC)c1OC CHEMBL3341789 IC50 24.0 nM
CN1CCN(c2ccc(-c3ccn4c(-c5ccnc6ccccc56)cnc4c3)cc2)CC1 CHEMBL4783586 IC50 24.0 nM
CN1CCN(c2ccc(Nc3nccc(-c4c(-c5cccnc5)nn5c4COCC5)n3)cc2)CC1 CHEMBL4776838 IC50 24.7 nM
COCCN1CCN(c2ccc(Nc3nccc(-c4c(-c5cccnc5)nn5c4CCCC5)n3)cc2)CC1 CHEMBL4749744 IC50 24.9 nM
CC(N)c1ccc(-c2cnc3c(-c4ccc(S(N)(=O)=O)c5ccccc45)cnn3c2)cc1 CHEMBL4293917 IC50 25.0 nM
CC(C)n1cc(-c2cnc(N)c3c2CCN(C2CCCCC2)C3=O)cn1 CHEMBL5183080 IC50 25.0 nM
CC1CCC(N2CCc3c(-c4ccc(CN5CCC[C@H]5C)cc4)cnc(N)c3C2=O)CC1 CHEMBL5209509 IC50 26.0 nM
c1cc(-c2cnn3cc(-c4ccc(N5CCNCC5)cc4)cnc23)c2cccnc2c1 CHEMBL2385591 IC50 26.2 nM
CN(C)CCCOc1ccc(-c2cnc3c(-c4ccnc5ccccc45)cnn3c2)cc1 CHEMBL3668019 IC50 26.68 nM
NS(=O)(=O)c1ccc(-c2cnn3cc(-c4ccc(CN5CCCC5)cc4)cnc23)c2ccccc12 CHEMBL4281166 IC50 27.0 nM
COc1cc(-c2cncc(-c3ccc(N4CCOCC4)cc3)c2C)cc(OC)c1OC CHEMBL4642622 IC50 28.0 nM
COCCN1CCN(c2ccc(Nc3nccc(-c4c(-c5cccnc5)nn5c4CCC5)n3)cc2)CC1 CHEMBL4797111 IC50 28.9 nM
CC(C)(N)c1ccc(-c2cnc3c(-c4ccc(S(N)(=O)=O)c5ccccc45)cnn3c2)cc1 CHEMBL4283315 IC50 29.0 nM
COc1cc(-c2cncc(-c3ccc(N4CCN(S(C)(=O)=O)CC4)cc3)c2C)cc(OC)c1OC CHEMBL4638544 IC50 29.0 nM
COc1cc(-c2cc(-c3ccc(N4CCNCC4)cc3)cnc2N)cc(F)c1OC CHEMBL4781201 IC50 29.0 nM
C[C@@H]1CCCN1Cc1ccc(-c2cnc(N)c3c2CCN(C2CCC(O)CC2)C3=O)cc1 CHEMBL5195463 IC50 29.0 nM
COc1cc(NS(C)(=O)=O)cc(-c2cc(-c3ccc(N4CCNCC4)cc3)cnc2C)c1 CHEMBL4779127 IC50 31.0 nM
Cc1cc(Nc2cc(N3CCN(C)CC3)nc(C=Cc3ccccc3)n2)n[nH]1 CHEMBL1983923 pKi 31.62 nM
COc1ccc(-c2cnc3c(-c4cccc5ncccc45)cnn3c2)cc1 CHEMBL502351 IC50 32.0 nM
O=c1c2cc(-c3ccnc4ccccc34)ccc2ncn1-c1ccc(N2CCOCC2)cc1 CHEMBL4244382 IC50 32.0 nM
Cc1cc(-c2cnc3cc(-c4ccc(N5CCNCC5)cc4)ccn23)c2cc(F)cc(F)c2n1 CHEMBL4786529 IC50 32.2 nM
CC(C)N1CCN(Cc2ccc(-c3cnc(N)c(C(=O)NC[C@@](C)(O)C(F)(F)F)n3)cc2)CC1 CHEMBL5189432 IC50 33.0 nM
COc1ccc(-c2cnc3c(-c4ccnc5ccccc45)cnn3c2)cc1 CHEMBL511563 IC50 33.3 nM
Cc1cc(-c2cnc3cc(-c4cnc(N5CCC6(CCCN6)C5)c(C)c4)ccn23)c2ccccc2n1 CHEMBL4757547 IC50 37.0 nM
Cc1cc(-c2cnc3cc(-c4ccc(N5CCN(C)CC5)cc4)ccn23)c2ccc(F)cc2n1 CHEMBL4784557 IC50 38.1 nM
COc1ccc(Nc2nccc(-c3c[nH]nc3-c3cccnc3)n2)cc1 CHEMBL4798765 INH 38.8 nM
CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)c(OC)c2)nc1NC1CCOCC1 CHEMBL3301622 Kd apparent 39.0 nM
COc1cc(OC)cc(-c2cncc(-c3ccc(N4CCNCC4)cc3)c2C)c1 CHEMBL4637817 IC50 39.0 nM
CCc1c(-c2ccc(C(C)(C)O)cc2)[nH]c2nccnc12 CHEMBL1976420 pKi 39.81 nM
CCNc1nc(C)c(-c2ccnc(Nc3ccc(N4CCN(C(C)=O)CC4)cc3)n2)s1 CHEMBL1983715 pKi 39.81 nM
Cc1cc(Nc2ncc(F)c(NC3C4C=CC(C4)C3C(N)=O)n2)ccc1N1CCN(C)CC1 CHEMBL1967878 pKi 39.81 nM
O=C(NN=Cc1cc(Br)c(O)c(Br)c1)Nc1ccccc1 CHEMBL1983575 pKi 39.81 nM
CNc1nc(C)c(-c2ccnc(Nc3ccc(N4CCNCC4)cc3)n2)s1 CHEMBL1999484 pKi 39.81 nM
Cc1nc2cc(-c3nn(C(C)C)c4ncnc(N)c34)ccc2o1 CHEMBL3991933 Kd apparent 40.0 nM
C[C@@H]1CN(c2ccc(-c3n[nH]c4cnc(N5CCCCC5)nc34)cn2)CCN1 CHEMBL5181658 IC50 40.0 nM
c1ccc(-c2cnn3cc(-c4ccc(N5CCNCC5)cc4)cnc23)cc1 CHEMBL2385590 IC50 40.72 nM
C[C@@H]1CCCN1Cc1ccc(-c2cnc(N)c3c2CCN(C2CCCCC2)C3=O)cc1F CHEMBL5179266 IC50 41.0 nM
Cc1nc2ccc(-c3ccnc4ccccc34)c(C)c2c(=O)[nH]1 CHEMBL4247751 IC50 42.0 nM
COc1cc(-c2cncc(-c3ccc(N4CCNCC4)cc3)c2C2CC2)cc(OC)c1OC CHEMBL4646409 IC50 42.0 nM
c1ccc2c(-c3cnn4cc(-c5ccc(OCCN6CCOCC6)cc5)cnc34)ccnc2c1 CHEMBL3668018 IC50 42.77 nM
c1cc(N2CCNCC2)ccc1-c1cnc2c(-c3cn[nH]c3)cnn2c1 CHEMBL2385586 IC50 43.0 nM
Cc1cc(-c2cnc3cc(-c4ccc(N5C[C@@H](C)O[C@@H](C)C5)nc4)ccn23)c2ccccc2n1 CHEMBL4798287 IC50 46.3 nM
CC(C)(CN1CCCCC1)Oc1ccc(-c2cnc3c(-c4ccc(S(N)(=O)=O)c5ccccc45)cnn3c2)cc1 CHEMBL4278219 IC50 47.0 nM
NS(=O)(=O)c1ccc(-c2cnn3cc(-c4ccc(OCCN5CCCC5)cc4)cnc23)c2ccccc12 CHEMBL4288905 IC50 48.0 nM
CN(C)Cc1ccc(-c2cnc(N)c(C(=O)NC3CCCC3O)n2)cc1 CHEMBL5173187 IC50 48.0 nM
CN(C)Cc1ccc(-c2cnc(N)c(C(=O)NC[C@@](C)(O)C(F)(F)F)n2)cc1 CHEMBL5199757 IC50 49.0 nM
C[C@@](O)(CNC(=O)c1nc(-c2ccc(CN3CCNCC3)cc2)cnc1N)C(F)(F)F CHEMBL5200140 IC50 50.0 nM
C[C@]1(O)CC[C@H](NC(=O)c2nc(-c3ccc(CN4CCC(N5CCOCC5)CC4)cc3Cl)cnc2N)CC1 CHEMBL5196823 IC50 50.0 nM
CCN(CC)CCCNC(=O)c1cnc(N)c2c(-c3ccc(NC(=O)Nc4cccc(C)c4)cc3)csc12 CHEMBL1999414 pKi 50.12 nM
CN(C)CC(O)COc1ccc(Nc2nccc(Nc3cc(Cl)ccc3Cl)n2)cc1 CHEMBL101311 pKi 50.12 nM
COc1cc2c(Oc3ccc(NS(=O)(=O)c4cc(F)ccc4F)cc3F)ccnc2cc1OCCCN1CCN(C)CC1 CHEMBL4443828 Kd(free) 52.0 nM
c1cc(N2CCOCC2)ccc1-c1cnc2c(-c3cn[nH]c3)cnn2c1 CHEMBL2385579 IC50 53.4 nM
C[C@@H]1CNC[C@H](C)N1c1ccc(-c2cnc3c(-c4cccc5c(S(N)(=O)=O)cccc45)cnn3c2)cc1 CHEMBL4283587 IC50 54.0 nM
CN1CCN(c2ccc(-c3ccn4c(-c5csc6cncnc56)cnc4c3)cc2)CC1 CHEMBL4761728 IC50 55.8 nM
C[C@@H]1CCCN1Cc1ccc(-c2cnc(N)c3c2CCN(C2CCC(C)(O)CC2)C3=O)cc1 CHEMBL5190065 IC50 56.0 nM
CCCS(=O)(=O)Nc1cc(-c2cc(-c3ccc(N4CCNCC4)cc3)cnc2N)cc(OC)c1OC CHEMBL4781373 IC50 57.0 nM
CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4ccc(O)cc4)c(=O)n(C)c3n2)cc1 CHEMBL4870434 IC50 59.0 nM
C[C@@H]1CCCN1Cc1ccc(-c2cnc(N)c3c2CN(C2CCCCC2)C3=O)cc1F CHEMBL5184888 IC50 60.0 nM
Cn1ccc(-c2cnc(N)c3c2CCN(C2CCCCC2)C3=O)c1 CHEMBL5197416 IC50 61.0 nM
CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4ccccc4Cl)c(=O)n(C)c3n2)cc1 CHEMBL4853179 IC50 62.0 nM
COc1cc(-c2cc(-c3ccc(N4CCNCC4)cc3)cnc2N)ccc1Cl CHEMBL3341952 IC50 63.0 nM
NS(=O)(=O)c1ccc(-c2cnn3cc(-c4ccc(OCCN5CCCCC5)cc4)cnc23)c2ccccc12 CHEMBL4285523 IC50 63.0 nM
O=C1Cc2c([nH]c3ccc([N+](=O)[O-])cc23)-c2ccccc2N1 CHEMBL50894 pKi 63.1 nM
Nc1ncnc2c1c(-c1cnc3[nH]ccc3c1)nn2C1CCCC1 CHEMBL1081312 pKi 63.1 nM
O=C(Nc1cccc(C(F)(F)F)n1)Nc1ccnc2c(F)ccc(F)c12 CHEMBL2001987 pKi 63.1 nM
CNC1CC2OC(C)(C1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL1980995 pKi 63.1 nM
CC(C)(C)n1nc(-c2ccc(Cl)cc2)c2c(N)ncnc21 CHEMBL406845 pKi 63.1 nM
c1cncc(-c2nn3c(c2-c2ccnc(Nc4ccc(N5CCOCC5)cc4)n2)COCC3)c1 CHEMBL4749510 IC50 65.8 nM
COc1cc(-c2cncc(-c3ccc(N4CCNCC4)cc3)c2C(F)(F)F)cc(OC)c1OC CHEMBL4635902 IC50 67.0 nM
Cn1cc(-c2cnc(N)c3c2CCN(C2CCCCC2)C3=O)cn1 CHEMBL5197788 IC50 67.0 nM
c1cc(-c2cnn3cc(-c4ccc(OCCN5CCCCC5)cc4)cnc23)ccn1 CHEMBL478629 IC50 67.5 nM
CN(C)c1ccc(-n2cnc3ccc(-c4ccnc5ccccc45)cc3c2=O)cc1 CHEMBL4237728 IC50 68.0 nM
CC(C)N1CCc2c(-c3cnn(C4CCNCC4)c3)cnc(N)c2C1=O CHEMBL5194265 IC50 72.0 nM
CC(C)NC(=O)c1nc(-c2ccc(CN(C)C)cc2)cnc1N CHEMBL5189664 IC50 73.0 nM
C[C@]12O[C@H](C[C@]1(O)CO)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)CNC4=O CHEMBL603469 Kd 75.0 nM
C[C@@](O)(CNC(=O)c1nc(-c2ccc(CN3CCS(=O)(=O)CC3)cc2)cnc1N)C(F)(F)F CHEMBL5195256 IC50 76.0 nM
C[C@@H]1CN(c2ccc(-c3n[nH]c4cnc(N5CCCCC5)cc34)cn2)CCN1 CHEMBL5199942 IC50 77.0 nM
O=C(Nc1c[nH]nc1-c1nc2ccc(CN3CCOCC3)cc2[nH]1)NC1CC1 CHEMBL495727 Kd apparent 78.0 nM
Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1 CHEMBL5416410 pKi 79.43 nM
COc1cccc(-c2cc(-c3ccc(N4CCNCC4)cc3)cnc2N)c1 CHEMBL3341948 IC50 86.0 nM
CCS(=O)(=O)Nc1cc(OC)cc(-c2cc(-c3ccc(N4CCNCC4)cc3)cnc2C)c1 CHEMBL4776443 IC50 86.0 nM
C[C@@](O)(CNC(=O)c1nc(-c2ccc(CN3CCOCC3)cc2)cnc1N)C(F)(F)F CHEMBL5169969 IC50 90.0 nM
CCc1nc2ccc(-c3ccnc4ccccc34)c(C)c2c(=O)[nH]1 CHEMBL4238262 IC50 91.0 nM
CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(Cc4cccc(S(C)(=O)=O)c4)c3n2)cc1 CHEMBL4864576 IC50 92.0 nM
NS(=O)(=O)c1ccc(-c2cnn3cc(-c4ccc(C5CCNCC5)cc4)cnc23)c2ccccc12 CHEMBL4277239 IC50 93.0 nM
C[C@@H]1CN(c2ccc(-c3n[nH]c4ccc(N5CCCCC5)nc34)cn2)CCN1 CHEMBL5187962 IC50 95.0 nM
Nc1ncc(-c2cnn(CCO)c2)c2scc(-c3ccc(NC(=O)Nc4ccc(OC(F)F)cc4)cc3)c12 CHEMBL1972220 pKi 100.0 nM
CCc1c(-c2ccc(C(C)=O)cc2)[nH]c2nccnc12 CHEMBL1994555 pKi 100.0 nM
O=C1NC(=O)c2c1c(-c1ccccc1Cl)cc1[nH]c3ccc(O)cc3c21 CHEMBL379975 pKi 100.0 nM
CCN(CC)CCCNC(=O)c1cnc(N)c2c(-c3ccc(NC(=O)Nc4cccc(F)c4)cc3)csc12 CHEMBL1996649 pKi 100.0 nM
CN1CCN(c2ccc(Nc3ncc(Cl)c(Nc4ccc5[nH]ncc5c4)n3)cc2)CC1 CHEMBL1979690 pKi 100.0 nM
CC(C)Oc1ccc(-c2cnc3c(-c4ccnc5ccccc45)cnn3c2)cc1 CHEMBL2385597 IC50 100.0 nM
CCNC(=O)c1nc(-c2ccc(CN(C)C)cc2)cnc1N CHEMBL5169935 IC50 100.0 nM
CCN(CC)Cc1ccc(-c2cnc(N)c(C(=O)NC[C@@](C)(O)C(F)(F)F)n2)cc1 CHEMBL5178109 IC50 100.0 nM
C[C@@](O)(CNC(=O)c1nc(-c2ccc(CN3CCCC3)cc2)cnc1N)C(F)(F)F CHEMBL5187534 IC50 100.0 nM
COc1cc(C(N)=O)cc(-c2cncc(-c3ccc(N4CCNCC4)cc3)c2C)c1 CHEMBL4457642 IC50 102.0 nM
COc1cc(-c2cncc(-c3ccc(N4CCNCC4)cc3)c2OC)cc(OC)c1OC CHEMBL4633535 IC50 103.0 nM
CCCS(=O)(=O)Nc1cc(OC)cc(-c2cc(-c3ccc(N4CCNCC4)cc3)cnc2C)c1 CHEMBL4782562 IC50 108.0 nM
C[C@@H]1CNC[C@H](C)N1c1ccc(-c2cnc3c(-c4cccc(S(N)(=O)=O)c4)cnn3c2)cc1 CHEMBL4281706 IC50 109.0 nM
COc1ccc(-c2cnc3c(-c4cn[nH]c4)cnn3c2)cc1 CHEMBL2385600 IC50 110.0 nM
COc1cc(-c2cc(-c3ccc(N4CCNCC4)cc3)cnc2N)ccc1C CHEMBL3341953 IC50 110.0 nM
Nc1ncc(-c2cccc(N3CCNCC3)c2)cc1-c1ccnc2ccccc12 CHEMBL3341792 IC50 110.0 nM
CC(O)CNC(=O)c1nc(-c2ccc(CN(C)C)cc2)cnc1N CHEMBL5204716 IC50 110.0 nM
C[C@@H]1CCCN1Cc1ccc(-c2cnc(N)c3c2CCN(C2CCC(O)CC2)C3=O)cc1F CHEMBL5191364 IC50 117.0 nM
Nc1ncc(-c2ccc(N3CCNCC3)cc2)cc1-c1ccnc2ccccc12 CHEMBL3341791 IC50 120.0 nM
O=C(O)C1(Cc2cccc(Nc3nccs3)n2)CCC(Oc2cccc(Cl)c2F)CC1 CHEMBL3182444 Kd apparent 121.0 nM
CCN1CCN(c2ccc(Nc3ncc(Cl)c(Nc4ccc5[nH]ncc5c4)n3)cc2)CC1 CHEMBL1967998 pKi 125.89 nM
O=C(Nc1cccc(C(F)(F)F)n1)Nc1ccnc2cc(OC(F)F)ccc12 CHEMBL1981215 pKi 125.89 nM
O=C(O)C1CN(Cc2ccc(OCc3ccccc3)cc2Cl)C1 CHEMBL1987998 pKi 125.89 nM
CCc1ccc2c(NC(=O)Nc3cccc(C(F)(F)F)n3)ccnc2c1 CHEMBL1986756 pKi 125.89 nM
Cc1cc(=O)n2ccc(CN(C)C)c(O)c2n1 CHEMBL1988581 pKi 125.89 nM
COC(C(=O)N1Cc2[nH]nc(NC(=O)c3ccc(N4CCN(C)CC4)cc3)c2C1)c1ccccc1 CHEMBL1981047 pKi 125.89 nM
Cc1cc(-c2cnc3cc(-c4ccc(N5CCN(C)CC5)cc4)ccn23)c2cc(C(F)(F)F)ccc2n1 CHEMBL4784045 IC50 135.0 nM
Cn1c(=O)c(-c2c(Cl)cccc2Cl)cc2cnc(Nc3ccc(S(C)(=O)=O)cc3)nc21 CHEMBL4868894 IC50 136.0 nM
Cc1nc2ccc(-c3cccc4ncccc34)cc2c(=O)[nH]1 CHEMBL4243957 IC50 138.0 nM
O=C(c1ccc(/C=C/c2n[nH]c3ccccc23)cc1)N1CCNCC1 CHEMBL1908397 Kd 140.0 nM
CN(C)Cc1ccc(-c2cnc(N)c(C(=O)NCC(O)C(F)(F)F)n2)cc1 CHEMBL5203120 IC50 140.0 nM
CC1CCC(N2CCc3c(-c4ccc(CN5CCC[C@H]5C)c(F)c4)cnc(N)c3C2=O)CC1 CHEMBL5209497 IC50 142.0 nM
CCCS(=O)(=O)NCc1cc(-c2cc(-c3ccc(N4CCNCC4)cc3)cnc2N)ccc1OC CHEMBL4783273 IC50 145.0 nM
Cc1cc(-c2cnc3cc(-c4ccc(N5CCN(C)CC5)cc4)ccn23)c2ncnn2c1 CHEMBL4796887 IC50 148.0 nM
Cc1cc(-c2cnc3cc(-c4ccc(N5CC6(C5)CC(F)(F)C6)nc4)ccn23)c2ccccc2n1 CHEMBL4781547 IC50 148.0 nM
COc1cc2/c(=N/c3ccc(Br)cc3F)nc[nH]c2cc1OCC1CCN(C)CC1 CHEMBL24828 Kd 150.0 nM
Cc1cnc(Nc2ccc(OCCN3CCCC3)cc2)nc1Nc1cccc(S(=O)(=O)NC(C)(C)C)c1 CHEMBL1287853 Kd 150.0 nM
Cc1ccnc2[nH]c3cc(C(C)C)ccc3c(=O)c12 CHEMBL1989471 pKi 158.49 nM
CC(Oc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl CHEMBL1825138 pKi 158.49 nM
c1ccc(CNc2nc(Nc3cc(C4CC4)[nH]n3)c3sccc3n2)cc1 CHEMBL1997924 pKi 158.49 nM
CNS(=O)(=O)c1ccccc1Nc1nc(Nc2cc(OC)c(OC)c(OC)c2)ncc1Cl CHEMBL1993661 pKi 158.49 nM
CSc1cccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)c1 CHEMBL386051 Kd 160.0 nM
O=c1c2cc(-c3ccnc4ccccc34)ccc2ncn1CCCN1CCOCC1 CHEMBL4237276 IC50 165.0 nM
O=c1[nH]cnc2ccc(-c3ccnc4ccccc34)cc12 CHEMBL4245292 IC50 167.0 nM
COc1ccc(Nc2nccc(-c3c(-c4cccnc4)nn4c3COCC4)n2)cc1 CHEMBL4747414 IC50 167.0 nM
Cc1c(-c2ccc(N3CCNCC3)cc2)cncc1-c1ccc2c(c1)CNC2=O CHEMBL4575999 IC50 171.0 nM
CCc1c(-c2ccc(N3CCNCC3)cc2)cncc1-c1cc(OC)c(OC)c(OC)c1 CHEMBL4641897 IC50 181.0 nM
Cn1cnc2ccc(-c3ccnc4ccccc34)cc2c1=O CHEMBL4250025 IC50 186.0 nM
CC(C)c1c2cc(-c3ccnc(Nc4ccc5c(N6CCN(C)CC6)ccnc5c4)n3)ccc2nn1C CHEMBL4856177 IC50 186.0 nM
Cc1c(-c2cccc3ncccc23)ccc2nc[nH]c(=O)c12 CHEMBL4250114 IC50 194.0 nM
COc1ccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(CC(C)(C)O)c5)cnc(N)c34)cc2)cc1 CHEMBL2004290 pKi 199.53 nM
NC(=O)c1ccc2nc(-c3ccc([N+](=O)[O-])o3)cn2c1 CHEMBL1973359 pKi 199.53 nM
N#Cc1cccc(NC(=O)Nc2ccnc3cc(C(F)(F)F)ccc23)n1 CHEMBL1968868 pKi 199.53 nM
COc1ccccc1-c1ccnc(Nc2cccc(S(C)(=O)=O)c2)n1 CHEMBL1975903 pKi 199.53 nM
Cn1cc(-c2cnc(N)c3c(-c4ccc(NC(=O)Nc5cccc(F)c5)cc4)csc23)cn1 CHEMBL1970317 pKi 199.53 nM
CCCS(=O)(=O)Nc1cc(-c2cc(-c3ccc(N4CCNCC4)cc3)cnc2N)cc(Cl)c1OC CHEMBL4793153 IC50 202.0 nM
Cc1cc(-c2cnc3cc(-c4ccc(N5CCN(C(C)C)CC5)cc4)ccn23)c2cc(F)ccc2n1 CHEMBL4778527 IC50 216.0 nM
COc1cc(O)c2c(c1)CCC[C@H](O)[C@H](O)C(=O)CCC[C@H](C)OC2=O CHEMBL4099337 IC50 217.0 nM
Oc1cccc(Nc2ccnc3[nH]c4ccccc4c23)c1 CHEMBL3133821 IC50 220.0 nM
Cc1c(-c2ccnc3ccccc23)ccc2nc[nH]c(=O)c12 CHEMBL4243400 IC50 220.0 nM
CC(=O)c1cnc2ccc(-c3cc(Cl)c(O)c(Cl)c3)nc2c1N[C@H]1CC[C@H](CN(C)C)CC1 CHEMBL3688339 Kd apparent 222.0 nM
C[C@@H]1CCCN1Cc1ccc(-c2cnc(N)c3c2CCN(C2CCC(C)(O)CC2)C3=O)cc1F CHEMBL5184929 IC50 227.0 nM
COc1cc(NS(=O)(=O)C(C)C)cc(-c2cc(-c3ccc(N4CCNCC4)cc3)cnc2C)c1 CHEMBL4792227 IC50 239.0 nM
Cc1cc(-c2cnn3cc(-c4ccc(N5[C@H](C)CNC[C@@H]5C)cc4)cnc23)ccc1S(N)(=O)=O CHEMBL4285138 IC50 246.0 nM
Cc1nc2ccc(-c3ccnc4ccccc34)cc2c(=O)[nH]1 CHEMBL4247727 IC50 248.0 nM
CCS(=O)(=O)c1cccc(-c2cc(C(=O)NC3CCN(C)CC3)c(C)c3[nH]c4ncc(C)cc4c23)c1 CHEMBL3544932 Kd apparent 249.0 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(CC(C)O)c5)cnc(N)c34)cc2)c1 CHEMBL1989708 pKi 251.19 nM
COc1cc2c(cc1F)C(c1ccccc1Cl)=Nc1c(n[nH]c1C)N2 CHEMBL1980391 pKi 251.19 nM
COc1cc(-c2cncc(-c3ccc(N4CCNCC4)cc3)c2N)cc(OC)c1OC CHEMBL4635667 IC50 255.0 nM
Cc1c(-c2ccc(N3CCNCC3)cc2)cncc1-c1ccc(C(N)=O)c(F)c1 CHEMBL4571351 IC50 263.0 nM
Nc1ncc(-c2ccc(N3CCNCC3)cc2)cc1-c1cccc2ncccc12 CHEMBL3341793 IC50 270.0 nM
COCCN1CCN(c2ccc(Nc3nccc(-c4c(-c5ccccc5)nn5c4COCC5)n3)cc2)CC1 CHEMBL4760836 IC50 276.0 nM
CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4ccccc4)c(=O)n(C)c3n2)cc1 CHEMBL136244 IC50 284.0 nM
C[C@@H]1CNC[C@H](C)N1c1ccc(-c2cnc3c(-c4ccc(S(N)(=O)=O)c(N)c4)cnn3c2)cc1 CHEMBL4292331 IC50 291.0 nM
Cc1n[nH]c(C)c1-c1ccc2nc[nH]c(=O)c2c1 CHEMBL4246278 IC50 293.0 nM
CCOc1cc(NS(=O)(=O)C(C)C)cc(-c2cc(-c3ccc(N4CCNCC4)cc3)cnc2N)c1 CHEMBL4795976 IC50 299.0 nM
O=c1[nH]cnc2c(Cl)cccc12 CHEMBL1949855 pKi 316.23 nM
Cc1ccc2nccc(NC(=O)Nc3cccc(C(F)(F)F)n3)c2c1 CHEMBL1964444 pKi 316.23 nM
CNS(=O)(=O)c1ccc(-c2cnn3cc(-c4ccc(N5[C@H](C)CNC[C@@H]5C)cc4)cnc23)c2ccccc12 CHEMBL4278242 IC50 326.0 nM
Cc1ccc(-c2cnc(N)c3c2CCN(C2CCCCC2)C3=O)cc1 CHEMBL5189032 IC50 333.0 nM
O=c1[nH]cnc2ccc(-c3cccc4ncccc34)cc12 CHEMBL4245595 IC50 344.0 nM
CCCS(=O)(=O)Nc1cc(-c2cc(-c3ccc(N4CCNCC4)cc3)cnc2N)cc(F)c1OC CHEMBL4789724 IC50 348.0 nM
CCCS(=O)(=O)Nc1cc(-c2cc(-c3ccc(N4CCNCC4)cc3)cnc2N)cc(OC)c1C CHEMBL4781290 IC50 355.0 nM
Cn1cnc2ccc(-c3cccc4ncccc34)cc2c1=O CHEMBL4249920 IC50 383.0 nM
O=c1[nH]cnc2ccc(-c3c[nH]nc3C3CC3)cc12 CHEMBL4249083 IC50 386.0 nM
CCCS(=O)(=O)Nc1cc(-c2cc(-c3ccc(N4CCNCC4)cc3)cnc2N)ccc1O CHEMBL4786295 IC50 387.0 nM
CN(C)CC(=O)N1CCC(c2ccc(NC(=O)c3nc(C#N)c[nH]3)c(C3=CCCCC3)c2)CC1 CHEMBL1908395 Kd 390.0 nM
CCCS(=O)(=O)Nc1cc(-c2cc(-c3ccc(N4CCNCC4)cc3)cnc2N)cc(C)c1OC CHEMBL4788375 IC50 395.0 nM
Cc1nc(N)sc1-c1ccnc(Nc2ccc(N3CCOCC3)cc2)n1 CHEMBL482967 Kd apparent 396.0 nM
NC(=O)c1c(OCc2c(F)cc(Br)cc2F)nsc1NC(=O)NCCCCN1CCCC1 CHEMBL253969 pKi 398.11 nM
CC(=O)NCC(=O)N1C2CCC1c1cc(Nc3ncc(C(F)(F)F)c(NC4CCC4)n3)ccc12 CHEMBL1983111 pKi 398.11 nM
Nc1ncc(-c2cnn(CCO)c2)c2scc(-c3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12 CHEMBL1980297 pKi 398.11 nM
NS(=O)(=O)c1ccc(-c2cnn3cc(-c4ccc(N5CCNCC5)nc4)cnc23)c2ccccc12 CHEMBL4280585 IC50 422.0 nM
O=c1c2cc(-c3ccnc4ccccc34)ccc2ncn1-c1ccccc1 CHEMBL4240187 IC50 431.0 nM
Cc1c(-c2ccnc3ccccc23)ccc2nc(Cc3ccccc3)[nH]c(=O)c12 CHEMBL4251441 IC50 439.0 nM
C[C@@H](Oc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl CHEMBL601719 Kd 440.0 nM
CN1CCC(CNc2ccc3ncc(-c4cccc(OC(F)(F)F)c4)n3n2)CC1 CHEMBL1952329 Kd apparent 458.0 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL388978 Kd 470.0 nM
CNC(=O)c1nn(C)c2c1C(C)(C)Cc1cnc(Nc3ccc(N4CCN(C)CC4)cc3)nc1-2 CHEMBL564829 Kd apparent 477.0 nM
Cc1c(-c2ccc(C(N)=O)cc2)cncc1-c1ccc(N2CCNCC2)cc1 CHEMBL4572458 IC50 477.0 nM
CN1C[C@@H]2CC[C@H](C1=O)N2c1ncc2[nH]nc(-c3cnn(C4CCC4)c3)c2n1 CHEMBL5286909 IC50 477.0 nM
CN1c2ccc(N)cc2C(c2ccccc2)c2cc(N)ccc21 CHEMBL1991734 pKi 501.19 nM
Nc1ncnc2c1C(=O)Nc1ccccc1N2 CHEMBL1980671 pKi 501.19 nM
Oc1cc(O)cc(C=Cc2ccc(O)c(O)c2)c1 CHEMBL1972346 pKi 501.19 nM
CCN(C(C)=O)c1ccc(Nc2nc(NC3CC3)c3nc[nH]c3n2)cc1 CHEMBL2006564 pKi 501.19 nM
Cn1ccc(-c2cnc(N)c3c2CCN(C2CCCCC2)C3=O)n1 CHEMBL5196975 IC50 514.0 nM
CCCS(=O)(=O)Nc1cc(-c2cc(-c3cccc(N4CCNCC4)c3)cnc2N)cc(F)c1OC CHEMBL4799077 IC50 522.0 nM
C[C@@H]1CNC[C@H](C)N1c1ccc(-c2cnc3c(-c4ccc(S(N)(=O)=O)cc4)cnn3c2)cc1 CHEMBL4277180 IC50 526.0 nM
CO[C@@H](C(=O)N1Cc2[nH]nc(NC(=O)c3ccc(N4CCN(C)CC4)cc3)c2C1)c1ccccc1 CHEMBL402548 Kd apparent 527.0 nM
c1cc(CN2CCOCC2)cc(Nc2nccc(NCCc3cnc[nH]3)n2)c1 CHEMBL5085698 IC50 537.0 nM
COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(N(C)C(=O)CN2CCN(C)CC2)cc1)c1ccccc1 CHEMBL502835 Kd 600.0 nM
Cc1ccnc(Nc2cc(C)nc(-c3ccccc3)n2)c1 CHEMBL1985367 pKi 630.96 nM
NC(=O)c1ccc(-c2c[nH]c3nccc(Cl)c23)cc1 CHEMBL1982711 pKi 630.96 nM
COc1ccc(C2=NNc3cccc4c(OC)ccc2c34)cc1OC CHEMBL1997335 pKi 630.96 nM
Oc1cnc2ccc(-c3ccncc3)cc2c1 CHEMBL1973868 pKi 630.96 nM
NC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1973720 pKi 630.96 nM
Nc1noc2cccc(-c3cccc(O)c3)c12 CHEMBL1970340 pKi 630.96 nM
COc1ccc2c(NC(=O)Nc3cccc(C(F)(F)F)n3)ccnc2c1 CHEMBL1982660 pKi 630.96 nM
Nc1ncnc2scc(-c3ccccc3)c12 CHEMBL1975212 pKi 630.96 nM
O=c1[nH]cnc2ccc(-c3cnn4ccccc34)cc12 CHEMBL4250951 IC50 653.0 nM
COCCN1CCN(c2ccc(Nc3nccc(-c4c(-c5ccccn5)nn5c4COCC5)n3)cc2)CC1 CHEMBL4793870 IC50 665.0 nM
COCc1cc(-c2cncc(-c3ccc(N4CCNCC4)cc3)c2C)ccc1C(N)=O CHEMBL4440071 IC50 687.0 nM
COc1ccc(-c2cncc(-c3ccc(N4CCNCC4)cc3)c2C)cc1C(N)=O CHEMBL4535685 IC50 694.0 nM
COc1c(-c2cncc(-c3ccc(N4CCNCC4)cc3)c2C)csc1C(N)=O CHEMBL4456061 IC50 712.0 nM
NS(=O)(=O)c1ccc(-c2cnn3cc(-c4ccc(OCCN5CCCCC5)nc4)cnc23)c2ccccc12 CHEMBL4290804 IC50 738.0 nM
COc1cc(-c2cncc(-c3ccc(N4CCNCC4)cc3)c2C)sc1C(N)=O CHEMBL4552750 IC50 751.0 nM
CC(C)Oc1cccc(-c2cc(-c3ccc(N4CCNCC4)cc3)cnc2N)c1 CHEMBL3341951 IC50 790.0 nM
C[C@@H]1CN(c2ccc(-c3n[nH]c4cnc(N5[C@H](C)CNC[C@@H]5C)nc34)cn2)CCN1 CHEMBL5189003 IC50 793.0 nM
NC(COc1cncc(-c2ccc3c(c2)C(=Cc2ccc[nH]2)C(=O)N3)c1)Cc1ccccc1 CHEMBL1980407 pKi 794.33 nM
CC(Nc1cncc(-n2cnc3ccc(C#N)cc32)n1)c1ccccc1F CHEMBL1977138 pKi 794.33 nM
C#Cc1cn(C2CCCC2)c2ncnc(N)c12 CHEMBL1993877 pKi 794.33 nM
CCc1ccc2nccc(NC(=O)Nc3cccc(C(F)(F)F)n3)c2c1 CHEMBL2000934 pKi 794.33 nM
O=C(O)c1ccccc1Nc1ccnc(Nc2ccc([N+](=O)[O-])cc2)n1 CHEMBL242865 pKi 794.33 nM
C[C@@H]1CNC[C@H](C)N1c1ccc(-c2cnc3c(-c4ccc(NS(C)(=O)=O)c5ccccc45)cnn3c2)cc1 CHEMBL4291950 IC50 796.0 nM
CN1CC2CCC(C1=O)C2c1ncc2[nH]nc(-c3cnn(C)c3)c2n1 CHEMBL5290074 IC50 930.0 nM
Cn1c(=O)c(-c2c(Cl)cccc2Cl)cc2cnc(Nc3cccc(S(C)(=O)=O)c3)nc21 CHEMBL4864600 IC50 972.0 nM
COc1cc(Nc2ccnc3ccc(Br)cc23)cc(OC)c1OC CHEMBL4443342 Kd 980.0 nM
COc1cc(-n2cnc3cc(-c4cnn(C)c4)ccc32)cc(OC(F)F)c1C(=O)NC1CC1 CHEMBL5417444 IC50 992.0 nM
O=C(Nc1cccc(C(F)(F)F)n1)Nc1ccnc2cc(Cl)ccc12 CHEMBL1981744 pKi 1000.0 nM
Nc1n[nH]c2cccc(-c3ccc(F)cc3)c12 CHEMBL1971519 pKi 1000.0 nM
CC(N)C1CCC(C(=O)Nc2ccnc3[nH]ccc23)CC1 CHEMBL2002992 pKi 1000.0 nM
Cc1cc(Nc2nc(Cl)cc(NCc3ccccc3)n2)n[nH]1 CHEMBL2005449 pKi 1000.0 nM
O=C1NCCc2[nH]c(-c3ccncc3)cc21 CHEMBL225519 pKi 1000.0 nM
COc1ccc(C(=O)Nc2n[nH]c3ccc(-c4cn(Cc5ccccc5)nn4)cc23)cc1OC CHEMBL1991078 pKi 1000.0 nM
CCc1n[nH]cc1-c1ccc2nc[nH]c(=O)c2c1 CHEMBL4240335 IC50 1000.0 nM
Cc1cc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)ccc1F CHEMBL574058 IC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3cn(Cc4ccccc4)nc3C2=O)COc2ccccc21 CHEMBL4088216 pIC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3c(nn(Cc4ccccc4)c3Br)C2=O)COc2ccccc21 CHEMBL4549667 pIC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3cn(CC4CCS(=O)(=O)CC4)nc3C2=O)COc2ccccc21 CHEMBL4097778 pIC50 1000.0 nM