Nc1ncnn2c(CCCCO)cc(-c3ccc(CO)cc3)c12 CHEMBL3667966 IC50 1.0 nM
COc1cc(-c2cc([C@H]3CC[C@H](O)CC3)n3ncnc(N)c23)cc(F)c1CO CHEMBL3667990 IC50 1.0 nM
O=C(Nc1cc(Nc2c(Cl)cnc3c2OCO3)ccn1)C1CC1 CHEMBL3818173 IC50 1.1 nM
COc1cc(-c2cc(C(O)C3CC3)n3ncnc(N)c23)ccc1CO CHEMBL3667999 IC50 1.2 nM
Nc1ncnn2c(C(O)C3CC3)cc(-c3cc(F)c(CO)c(F)c3)c12 CHEMBL3667967 IC50 1.3 nM
CNC1CC2OC(C)(C1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL1980995 IC50 1.361 nM
COc1cc(-c2cc(-c3cccc(O)c3)cnc2N)cc(OC)c1OC CHEMBL1230714 IC50 1.8 nM
Nc1ncnn2c([C@@H]3CCCNC3)cc(-c3cc(F)c(CO)c(F)c3)c12 CHEMBL3667973 IC50 1.9 nM
CC(C)c1cc(-c2cc(F)c(CO)c(F)c2)c2c(N)ncnn12 CHEMBL3668000 IC50 1.9 nM
CCCc1cc(-c2ccc(CO)cc2)c2c(N)ncnn12 CHEMBL3667963 IC50 2.0 nM
Nc1ncnn2c1c(-c1cc(F)c(CO)c(F)c1)cc2[C@H]1CC[C@H](O)CC1 CHEMBL3667969 IC50 2.0 nM
Nc1nc(-c2cc(-c3ccc(CO)cc3)c3c(N)ncnn23)cs1 CHEMBL3667979 IC50 2.0 nM
COc1cc(-c2cc(C3CCCNC3)n3ncnc(N)c23)cc(F)c1CO CHEMBL3667991 IC50 2.0 nM
CCc1nc(-c2cc(-c3cc(F)c(CO)c(F)c3)c3c(N)ncnn23)cs1 CHEMBL3667978 IC50 2.6 nM
CCCc1cc(-c2cc(F)c(CO)c(F)c2)c2c(N)ncnn12 CHEMBL3667964 IC50 2.8 nM
CC(C)n1nc(-c2cc3cc(O)ccc3[nH]2)c2c(N)ncnc21 CHEMBL1241674 Kd 2.9 nM
CC(O)c1cc(-c2cc(F)c(CO)c(F)c2)c2c(N)ncnn12 CHEMBL3668001 IC50 3.8 nM
Nc1ncnn2c(CCCO)cc(-c3ccc(CO)cc3)c12 CHEMBL3667965 IC50 4.0 nM
Cc1nc(-c2cc(-c3ccc(CO)cc3)c3c(N)ncnn23)cs1 CHEMBL3667975 IC50 4.0 nM
Cc1cc(-c2cc(C3CCCNC3)n3ncnc(N)c23)cc(F)c1CO CHEMBL3667992 IC50 4.0 nM
Cc1cc(-c2cc(C3CCNC3)n3ncnc(N)c23)cc(F)c1CO CHEMBL3667993 IC50 4.0 nM
CCc1cc(-c2cc(C3CCCNC3)n3ncnc(N)c23)cc(F)c1CO CHEMBL3667997 IC50 4.0 nM
NCc1nc(-c2cc(-c3cc(F)c(CO)c(F)c3)c3c(N)ncnn23)cs1 CHEMBL3667995 IC50 4.1 nM
Nc1ncnn2c(C3CCNC3)cc(-c3cc(F)c(CO)c(F)c3)c12 CHEMBL3667970 IC50 4.4 nM
C[C@@H](Cc1c(F)c(F)cc(F)c1F)Nc1cc[nH]c(=O)c1-c1nc2cc3c(cc2[nH]1)CN(CCN(C)C)C3=O CHEMBL3671311 IC50 4.701 nM
Cc1nc(-c2cc(-c3cc(F)c(CO)c(F)c3)c3c(N)ncnn23)cs1 CHEMBL3667976 IC50 5.3 nM
Nc1ncnn2c(C3(O)CCCNC3)cc(-c3cc(F)c(CO)c(F)c3)c12 CHEMBL3667971 IC50 5.7 nM
CCc1cc(-c2cc(C(O)C3CC3)n3ncnc(N)c23)cc(F)c1CO CHEMBL3667998 IC50 5.7 nM
Nc1ncnn2c([C@H]3CCCNC3)cc(-c3cc(F)c(CO)c(F)c3)c12 CHEMBL3667974 IC50 5.9 nM
COC(=O)N1C[C@@H](C)N(c2ncc3[nH]nc(-c4ccc(N5CCN[C@H](C)C5)nc4)c3n2)[C@@H](C)C1 CHEMBL5184000 IC50 5.9 nM
COc1cc(-c2cncc(-c3ccc(N4CCN(C(C)C)CC4)cc3)c2C)cc(F)c1C(N)=O CHEMBL4548795 IC50 7.0 nM
Nc1ncnn2c(C3CCNCC3)cc(-c3ccc(CO)cc3)c12 CHEMBL3667972 IC50 8.0 nM
CC(Cc1cc(F)ccc1F)Nc1cc[nH]c(=O)c1-c1nc2cc3c(cc2[nH]1)C(=O)N(CCN(C)C)C3 CHEMBL3671318 IC50 9.157 nM
C[C@@H](Cc1c(F)c(F)cc(F)c1F)Nc1cc[nH]c(=O)c1-c1nc2cc3c(cc2[nH]1)CN(C1CCN(C)CC1)C3=O CHEMBL3671309 IC50 9.812 nM
C[C@@H]1CN(c2ccc(-c3n[nH]c4cnc(N5[C@H](C)CN(C(=O)N6CCCC6)C[C@@H]5C)nc34)cn2)CCN1 CHEMBL5199417 IC50 10.0 nM
COC(=O)N1C[C@@H](C)N(c2ncc3[nH]nc(-c4ccc(N5CCN(C)CC5)nc4)c3n2)[C@@H](C)C1 CHEMBL5186341 IC50 10.0 nM
Nc1ncc(-c2cnn(C3CCCNC3)c2)c2c1C(=O)N(C1CCCCC1)CC2 CHEMBL5205781 IC50 11.0 nM
c1ccc2c(-c3cnn4cc(-c5ccc(N6CCNCC6)cc5)cnc34)ccnc2c1 CHEMBL513147 IC50 11.13 nM
c1ccc2c(-c3coc4cc(-c5ccc(N6CCNCC6)cc5)cnc34)ccnc2c1 CHEMBL5083143 IC50 13.0 nM
C[C@@H](Cc1c(F)c(F)cc(F)c1F)Nc1cc[nH]c(=O)c1-c1nc2cc3c(cc2[nH]1)C(=O)N(CCN(C)C)C3=O CHEMBL3671310 IC50 14.03 nM
c1cc(-c2cnn3cc(-c4ccc(N5CCNCC5)cc4)cnc23)c2cccnc2c1 CHEMBL2385591 IC50 14.4 nM
Cc1c2c(cc3[nH]c(-c4c(NC(C)Cc5c(F)c(F)cc(F)c5F)cc[nH]c4=O)nc13)C(=O)N(C1CCN(C)CC1)C2 CHEMBL3671320 IC50 14.59 nM
Nc1ncnn2c(C3(O)CCCCC3)cc(-c3cc(F)c(CO)c(F)c3)c12 CHEMBL3667994 IC50 15.0 nM
O=C(Nc1c[nH]nc1-c1nc2ccc(CN3CCOCC3)cc2[nH]1)NC1CC1 CHEMBL495727 Kd apparent 15.0 nM
COc1cc(-c2cncc(-c3ccc(N4CCNCC4)cc3)c2C)cc(OC)c1OC CHEMBL4517408 IC50 15.0 nM
Nc1ncc(-c2cnn(C3CCNCC3)c2)c2c1C(=O)N(C1CCCCC1)CC2 CHEMBL5186575 IC50 15.0 nM
CC(Cc1cc(F)ccc1F)Nc1cc[nH]c(=O)c1-c1nc2cc3c(cc2[nH]1)C(=O)N(C1CCN(C)CC1)C3=O CHEMBL3671312 IC50 15.11 nM
C[C@@H](Cc1c(F)c(F)cc(F)c1F)Nc1cc[nH]c(=O)c1-c1nc2cc3c(cc2[nH]1)C(O)N(c1cccnc1)C3=O CHEMBL3671314 IC50 15.18 nM
O=C(Nc1cc(Nc2c(Cl)ccc3c2OCO3)ccn1)C1CC1 CHEMBL3819089 IC50 17.0 nM
Nc1ncnn2c(CN3CCOCC3)cc(-c3ccc(CO)c(Cl)c3)c12 CHEMBL3667983 IC50 17.0 nM
CN1CCC(n2cc(-c3cnc(N)c4c3CCN(C3CCCCC3)C4=O)cn2)CC1 CHEMBL5200241 IC50 17.0 nM
Nc1ncnn2c(CN3CCOCC3)cc(-c3ccc(CO)cc3)c12 CHEMBL3667981 IC50 19.0 nM
COC(=O)N1C[C@@H](C)N(c2ncc3[nH]nc(-c4ccc(N5CCN(C)CC5)cc4)c3n2)[C@@H](C)C1 CHEMBL5181536 IC50 19.0 nM
COC(=O)N1C[C@@H](C)N(c2ncc3[nH]nc(-c4ccc(N5CCN(C)CC5)c(F)c4)c3n2)[C@@H](C)C1 CHEMBL5181872 IC50 22.0 nM
Cc1c2c(cc3nc(-c4c(NC(C)Cc5c(F)c(F)cc(F)c5F)cc[nH]c4=O)[nH]c13)CN(C1CCN(C)CC1)C2=O CHEMBL3671319 IC50 23.7 nM
Nc1ncnn2c(N3CCOCC3)cc(-c3ccc(CO)c(F)c3)c12 CHEMBL3668002 IC50 25.0 nM
Nc1ncc(-c2cnn(CC3CCNCC3)c2)c2c1C(=O)N(C1CCCCC1)CC2 CHEMBL5189461 IC50 25.0 nM
CN(c1ccnc(NC(=O)C2CC2)c1)c1c(Cl)cnc2c1OCO2 CHEMBL3818656 IC50 26.0 nM
COc1ccc(-c2cnc3c(-c4ccnc5ccccc45)cnn3c2)cc1 CHEMBL511563 IC50 26.5 nM
CC(C)Oc1ccc(-c2cnc3c(-c4ccnc5ccccc45)cnn3c2)cc1 CHEMBL2385597 IC50 27.0 nM
COc1cc(-c2cc(-c3ccc(N4CCNCC4)cc3)cnc2C)cc(OC)c1OC CHEMBL3341789 IC50 27.0 nM
Nc1ncc(-c2cnn(C3CCNCC3)c2)c2c1C(=O)N(C1C3CC4CC(C3)CC1C4)CC2 CHEMBL5175201 IC50 27.0 nM
Nc1ncc(-c2cnn(C3CCNCC3)c2)c2c1C(=O)N(C1CCC1)CC2 CHEMBL5197985 IC50 29.0 nM
Nc1ncnn2c(CN3CCOCC3)cc(-c3cc(F)c(CO)c(F)c3)c12 CHEMBL3667982 IC50 30.0 nM
Cc1cc(-c2cc(CN3CCOCC3)n3ncnc(N)c23)ccc1CO CHEMBL3667984 IC50 30.0 nM
Nc1ncnn2c(CN3CCC(O)C3)cc(-c3cc(F)c(CO)c(F)c3)c12 CHEMBL3667987 IC50 30.0 nM
CC(=O)N1CCC(n2cc(-c3cnc(N)c4c3CCN(C3CCCCC3)C4=O)cn2)CC1 CHEMBL5178564 IC50 31.0 nM
CC(Cc1cc(F)ccc1F)Nc1cc[nH]c(=O)c1-c1nc2cc3c(cc2[nH]1)C(=O)N(CCN(C)C)C3=O CHEMBL3671317 IC50 38.86 nM
Nc1ncc(-c2cnn(C3COC3)c2)c2c1C(=O)N(C1CCCCC1)CC2 CHEMBL5207070 IC50 39.0 nM
Cc1cc(-c2cnc3cc(-c4ccc(N5CCNCC5)cc4)ccn23)c2ccccc2n1 CHEMBL4740381 IC50 39.1 nM
CCC(=O)Nc1cc(Nc2c(Cl)ccc3c2OCO3)ccn1 CHEMBL3818920 IC50 40.0 nM
Nc1ncnn2c(C(O)C3CCOCC3)cc(-c3cc(F)c(CO)c(F)c3)c12 CHEMBL3667968 IC50 40.0 nM
Cc1nc2ccc(-c3ccnc4ccccc34)c(C)c2c(=O)[nH]1 CHEMBL4247751 Kd 41.0 nM
Nc1ncc(-c2cnn(CC3CCCNC3)c2)c2c1C(=O)N(C1CCCCC1)CC2 CHEMBL5195236 IC50 42.0 nM
c1cc(N2CCOCC2)ccc1-c1cnc2c(-c3cn[nH]c3)cnn2c1 CHEMBL2385579 IC50 42.1 nM
CC(C)n1cc(-c2cnc(N)c3c2CCN(C2CCCCC2)C3=O)cn1 CHEMBL5183080 IC50 45.0 nM
C[C@@H]1CCCN1Cc1ccc(-c2cnc(N)c(C(=O)N[C@H]3CC[C@](C)(O)CC3)c2)cc1F CHEMBL5205791 IC50 45.0 nM
COc1ccc(-c2cnc3c(-c4cccc5ncccc45)cnn3c2)cc1 CHEMBL502351 IC50 46.0 nM
C[C@@H](Cc1c(F)c(F)cc(F)c1F)Nc1cc[nH]c(=O)c1-c1nc2cc3c(cc2[nH]1)C(=O)N(c1cccnc1)C3=O CHEMBL3671313 IC50 47.3 nM
CC(=O)Nc1cc(Nc2c(Cl)ccc3c2OCO3)ccn1 CHEMBL3818628 IC50 48.0 nM
Nc1ncc(-c2cnn(C3CCCC3)c2)c2c1C(=O)N(C1CCCCC1)CC2 CHEMBL5189688 IC50 48.0 nM
CC(c1ccc(-c2cnc3c(-c4ccc(S(N)(=O)=O)c5ccccc45)cnn3c2)cc1)N1CCCC1 CHEMBL4283638 IC50 51.0 nM
COc1ccc(-c2cnc3c(-c4cn[nH]c4)cnn3c2)cc1 CHEMBL2385600 IC50 52.4 nM
c1cc(N2CCNCC2)ccc1-c1cnc2c(-c3cn[nH]c3)cnn2c1 CHEMBL2385586 IC50 55.0 nM
COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 CHEMBL509032 Kd 57.0 nM
CCc1nc(-c2cc(-c3ccc(CO)cc3)c3c(N)ncnn23)cs1 CHEMBL3667977 IC50 60.0 nM
CC1(O)CCC(N2CCc3c(-c4cnn(C5CCNCC5)c4)cnc(N)c3C2=O)CC1 CHEMBL5196379 IC50 61.0 nM
COc1cc(O)c2c(c1)CCC[C@H](O)[C@H](O)C(=O)CCC[C@H](C)OC2=O CHEMBL4099337 IC50 62.0 nM
Nc1ncnn2c(CN3CCC(O)CC3)cc(-c3cc(F)c(CO)c(F)c3)c12 CHEMBL3667986 IC50 65.0 nM
CSc1cccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)c1 CHEMBL386051 Kd 69.0 nM
Nc1ncnn2c(CN3CCCC(O)C3)cc(-c3cc(F)c(CO)c(F)c3)c12 CHEMBL3667988 IC50 70.0 nM
Nc1ncnn2c(CN3CCNCC3)cc(-c3ccc(CO)cc3)c12 CHEMBL3667980 IC50 80.0 nM
Cc1cc(-c2cnc3cc(-c4ccc(C5CNCCN5)cc4)ccn23)c2cc(F)cc(F)c2n1 CHEMBL4778971 IC50 89.2 nM
c1cc(-c2cnn3cc(-c4ccc(OCCN5CCCCC5)cc4)cnc23)ccn1 CHEMBL478629 IC50 106.3 nM
O=C(Nc1cc(Nc2cccc3c2OCO3)ccn1)C1CC1 CHEMBL3819259 IC50 120.0 nM
Nc1ncc(-c2ccc(CN3CCC(N4CCOCC4)CC3)cc2Cl)nc1C(=O)NC12CCC(O)(CC1)CC2 CHEMBL5193039 IC50 120.0 nM
CCc1cc(-c2cc([C@H]3CC[C@H](O)CC3)n3ncnc(N)c23)cc(F)c1CO CHEMBL3667989 IC50 124.0 nM
COc1cc(O)c2c(c1)CCC[C@H](O)[C@H](O)C(=O)/C=C\C[C@H](C)OC2=O CHEMBL2012519 IC50 125.0 nM
Nc1ncnn2c(CN3CCOCC3)cc(-c3ccc(CO)nc3)c12 CHEMBL3667985 IC50 140.0 nM
C[C@@H]1CCCN1Cc1ccc(-c2cnc(N)c3c2CCN(C2CCC(O)CC2)C3=O)cc1 CHEMBL5195463 IC50 155.0 nM
CC(C)N1CCc2c(-c3cnn(C4CCNCC4)c3)cnc(N)c2C1=O CHEMBL5194265 IC50 164.0 nM
Cc1cc(-c2cnc3cc(-c4ccc(N5CCNCC5)cc4)ccn23)c2cc(F)ccc2n1 CHEMBL4788859 IC50 166.3 nM
Cn1cc(-c2cnc(N)c3c2CCN(C2CCCCC2)C3=O)cn1 CHEMBL5197788 IC50 168.0 nM
COC1c2cc3[nH]c(-c4c(NC(C)Cc5c(F)c(F)cc(F)c5F)cc[nH]c4=O)nc3cc2C(=O)N1c1cccnc1 CHEMBL3671315 IC50 174.4 nM
C[C@@H]1CCCN1Cc1ccc(-c2cnc(N)c3c2CCN(C2CCCCC2)C3=O)cc1 CHEMBL5172921 IC50 190.0 nM
O=C(Nc1cc(Nc2c(Cl)ccc3c2OCO3)ccn1)C1CCC1 CHEMBL3819276 IC50 230.0 nM
Cc1c2c(cc3[nH]c(-c4c(NC(C)Cc5c(F)c(F)cc(F)c5F)cc[nH]c4=O)nc13)C(=O)N(C1CCN(C)CC1)C2=O CHEMBL3671321 IC50 231.3 nM
CC1CCC(N2CCc3c(-c4ccc(CN5CCC[C@H]5C)cc4)cnc(N)c3C2=O)CC1 CHEMBL5209509 IC50 262.0 nM
Cc1cc(-c2cnc3cc(-c4ccc(N5CCNCC5)cc4)ccn23)c2cc(F)cc(F)c2n1 CHEMBL4786529 IC50 308.8 nM
O=C(Nc1cc(Nc2c(Cl)ccc3c2OCO3)ccn1)c1ccccc1 CHEMBL3818797 IC50 340.0 nM
C[C@@H]1CCCN1Cc1ccc(-c2cnc(N)c3c2CCN(C2CCCCC2)C3=O)cc1F CHEMBL5179266 IC50 399.0 nM
C[C@@H]1CCCN1Cc1ccc(-c2cnc(N)c3c2CCN(C2CCC(C)(O)CC2)C3=O)cc1 CHEMBL5190065 IC50 410.0 nM
O=c1c2cc(-c3ccnc4ccccc34)ccc2ncn1-c1ccc(N2CCOCC2)cc1 CHEMBL4244382 Kd 420.0 nM
Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1 CHEMBL5416410 Kd 460.0 nM
COc1cc2/c(=N/c3ccc(Br)cc3F)nc[nH]c2cc1OCC1CCN(C)CC1 CHEMBL24828 Kd 470.0 nM
Cn1ccc(-c2cnc(N)c3c2CCN(C2CCCCC2)C3=O)c1 CHEMBL5197416 IC50 483.0 nM
C[C@@H]1CCCN1Cc1ccc(-c2cnc(N)c3c2CN(C2CCCCC2)C3=O)cc1F CHEMBL5184888 IC50 543.0 nM
C[C@@H]1CCCN1Cc1ccc(-c2cnc(N)c3c2CCN(C2CCC(O)CC2)C3=O)cc1F CHEMBL5191364 IC50 649.0 nM
COc1cc(O)c2c(c1)CCC[C@H](O)[C@H](O)[C@@H](O)CCC[C@H](C)OC2=O CHEMBL4061009 IC50 770.0 nM
CC(C)C(=O)Nc1cc(Nc2c(Cl)ccc3c2OCO3)ccn1 CHEMBL3818832 IC50 800.0 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL388978 IC50 850.0 nM
O=C(Nc1cc(Nc2c(Cl)ccc3c2OCO3)ccn1)C1CCCC1 CHEMBL3817884 IC50 940.0 nM
O=C(Nc1cc(Nc2ccncc2)ccn1)C1CC1 CHEMBL3818411 IC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3cn(Cc4ccccc4)nc3C2=O)COc2ccccc21 CHEMBL4088216 pIC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3c(nn(Cc4ccccc4)c3Br)C2=O)COc2ccccc21 CHEMBL4549667 pIC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3cn(CC4CCS(=O)(=O)CC4)nc3C2=O)COc2ccccc21 CHEMBL4097778 pIC50 1000.0 nM