COc1cc2nc(N3CCN(C(=O)c4ccco4)CC3)nc(N)c2cc1OC CHEMBL2 Kb 0.004 nM
COc1cccc(OC)c1OCCNCC1COc2ccccc2O1 CHEMBL25554 Ki 0.038 nM
COc1cccc(OC)c1OCCNC[C@@H]1C[C@H](c2ccccc2)c2ccccc2O1 CHEMBL42472 Log Ki 0.03981 nM
COc1cc2nc(N3CCN(C(=O)c4ccco4)[C@@H]4CCCC[C@@H]43)nc(N)c2cc1OC CHEMBL342062 pKi 0.07079 nM
COc1cc2c(cc1OC)CN(c1cc(N)c3cc(OC)c(OC)cc3n1)CC2 CHEMBL324090 Ki 0.08 nM
CCN(CC)c1ccc2cc(-n3cc(C(=O)N4CCN(c5nc(N)c6cc(OC)c(OC)cc6n5)CC4)nn3)c(=O)oc2c1 CHEMBL3582270 Ki 0.1 nM
COc1cc2nc(N(C)CCCCCCN(C)C(=O)c3ccco3)nc(N)c2cc1OC CHEMBL27013 Log Ki 0.1096 nM
CCCN(CCC)c1nc(N2CCN(C(=O)c3ccco3)[C@@H]3CCCC[C@@H]32)nc2cc(OC)c(OC)cc12 CHEMBL4126860 pKi 0.1288 nM
CCOc1ccccc1OCCN[C@H](C)Cc1ccc(OC)c(S(N)(=O)=O)c1 CHEMBL836 EC50 0.13 nM
COc1cc2nc(N3CCN(C(=O)c4ccco4)[C@H]4CCCC[C@H]43)nc(N)c2cc1OC CHEMBL423294 Log Ki 0.1349 nM
COc1cc2nc(N3CCN(C(=O)c4ccco4)[C@H]4CCCC[C@@H]43)nc(N)c2cc1OC CHEMBL2261604 pKi 0.1349 nM
COc1cc2nc(N3CCN(C(=O)COc4c(OC)cccc4C(C)C)[C@H]4CCCC[C@H]43)nc(N)c2cc1OC CHEMBL4129291 pKi 0.1514 nM
COc1cccc(OC)c1OCCNCCOc1ccccc1OCc1cccc(Cl)c1 CHEMBL198860 Log Ki 0.1585 nM
COc1cc2nc(N(C)CCCCCCN(C)C(=O)c3cccc(CN(C)C)c3)nc(N)c2cc1OC CHEMBL341665 Log Ki 0.166 nM
COc1cc2nc(N3CCN(C(=O)OCc4ccccc4)[C@@H]4CCCC[C@@H]43)nc(N)c2cc1OC CHEMBL4128084 pKi 0.1905 nM
COc1cc2nc(N3CCN(C(=O)c4cccs4)[C@H]4CCCC[C@H]43)nc(N)c2cc1OC CHEMBL242724 Log Ki 0.2399 nM
COc1cccc(OC)c1OCCNCCOc1ccccc1OCc1ccc(C)cc1 CHEMBL200366 Log Ki 0.2512 nM
COc1cccc(OC)c1OCCNCCOc1ccccc1OCc1cccc(C)c1 CHEMBL199080 Log Ki 0.2512 nM
COc1cc2nc(N3CCC[C@H](NC(=O)c4ccco4)C3)nc(N)c2cc1OC CHEMBL4161165 pKi 0.2818 nM
CCCN(CCC)c1nc(N2CCN(C(=O)c3ccco3)[C@H]3CCCC[C@H]32)nc2cc(OC)c(OC)cc12 CHEMBL4127483 pKi 0.302 nM
COc1cc2nc(N3CCN(C(=O)CC4CCSS4)CC3)nc(N)c2cc1OC CHEMBL178673 Log Ki 0.309 nM
COc1cc2nc(N3CCN(C(=O)c4ccc(Br)o4)[C@H]4CCCC[C@H]43)nc(N)c2cc1OC CHEMBL388884 Log Ki 0.309 nM
COc1cc2nc(N3CCN(C(=O)c4ccc(Br)o4)[C@H]4CCCC[C@@H]43)nc(N)c2cc1OC CHEMBL2261605 pKi 0.309 nM
COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(-c5ccccc5)csc4c3=O)C[C@@H]21 CHEMBL61483 Ki 0.33 nM
COc1cc2nc(N3CCN(C(=O)OCc4ccccc4)[C@H]4CCCC[C@H]43)nc(N)c2cc1OC CHEMBL4125981 pKi 0.3802 nM
COC(=O)c1ccccc1NCC1=NCCN1 CHEMBL414185 Log EC50 0.3981 nM
COc1ccc(COc2ccccc2OCCNCCOc2c(OC)cccc2OC)cc1 CHEMBL200580 Log Ki 0.3981 nM
COc1cccc(OC)c1OCCNCCOc1ccccc1OCc1ccc([N+](=O)[O-])cc1 CHEMBL196817 Log Ki 0.3981 nM
CSc1ccc(C)cc1NCC1=NCCN1 CHEMBL72441 Log EC50 0.4169 nM
COc1cc2nc(N3CCN(C(=O)C4COc5ccccc5O4)[C@H]4CCCC[C@H]43)nc(N)c2cc1OC CHEMBL564481 pKi 0.4169 nM
COc1cc2nc(N3CCN(C(=O)COc4c(OC)cccc4C(C)C)CC3)nc(N)c2cc1OC CHEMBL430717 Ki 0.45 nM
COc1cc2nc(N3CCN(c4ccco4)CC3)nc(N)c2cc1OC CHEMBL137598 Ki 0.46 nM
COc1cc2nc(N3CCN(C(=O)c4ccccc4)[C@H]4CCCC[C@H]43)nc(N)c2cc1OC CHEMBL242934 Log Ki 0.4898 nM
COc1cc2nc(N3CCN(C(=O)C4CCCO4)CC3)nc(N)c2cc1OC CHEMBL611 EC50 0.5 nM
CSc1ccc(Cl)cc1NCC1=NCCN1 CHEMBL70751 Log EC50 0.5012 nM
COc1cccc(OC)c1SCCNCCOc1ccccc1OCc1ccccc1 CHEMBL1254582 pKi 0.5012 nM
COc1cc2nc(N3CCC[C@H](NC4=CC(=O)c5ccccc5C4=O)C3)nc(N)c2cc1OC CHEMBL4163587 pKi 0.5248 nM
COc1cc2nc(N3CCN(C(=O)C4CCSS4)CC3)nc(N)c2cc1OC CHEMBL175934 Log Ki 0.537 nM
COc1cccc(OC)c1OCCNCCOc1ccccc1OCc1ccccc1 CHEMBL43116 Log Ki 0.537 nM
COc1cccc(OC)c1OCCNCCOc1ccccc1OCc1ccccc1Cl CHEMBL200839 Log Ki 0.5623 nM
COc1cc2nc(N3CCN(C(=O)c4ccco4)C4CCCCC43)nc(N)c2cc1OC CHEMBL97698 Log Ki 0.5888 nM
COC(=O)[C@H]1[C@H]2C[C@H]3c4[nH]c5ccccc5c4CCN3C[C@H]2CC[C@@H]1O CHEMBL10347 Ki 0.6 nM
COc1cc2nc(N3CCN(C(=O)C4COc5ccccc5O4)CC3)nc(N)c2cc1OC CHEMBL707 pKi 0.631 nM
COc1ccccc1N1CCN(CCNc2c(C(=O)C(C)C)c(-c3ccccc3)nn(C)c2=O)CC1 CHEMBL80730 Ki 0.64 nM
COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(OC)c(OC)ccc4c3=O)C[C@@H]21 CHEMBL293695 Ki 0.66 nM
COc1ccc2c(=O)n(CCN3C[C@@H]4CCc5c(OC)cccc5[C@@H]4C3)c(=O)[nH]c2c1 CHEMBL58956 Ki 0.66 nM
COc1cc2nc(N3CCN(C4=CC(=O)c5ccccc5C4=O)CC3)nc(N)c2cc1OC CHEMBL179743 Log Ki 0.6761 nM
COc1cc2[nH]c(=O)n(CCN3C[C@@H]4CCc5c(OC)cccc5[C@@H]4C3)c(=O)c2s1 CHEMBL62028 Ki 0.74 nM
COc1cc2nc(N3CCN(C(C)=O)[C@@H]4CCCC[C@@H]43)nc(N)c2cc1OC CHEMBL4129461 pKi 0.7413 nM
CC(=O)c1c(-c2ccccc2)nn(C)c(=O)c1NCCN1CCN(c2ccccc2Cl)CC1 CHEMBL310599 Ki 0.75 nM
COc1cc2nc(N3CCN(C(=O)C(C)(C)C)[C@H]4CCCC[C@H]43)nc(N)c2cc1OC CHEMBL4128460 pKi 0.7762 nM
COc1cccc(OC)c1OCCNCCOc1ccccc1OCc1cccc([N+](=O)[O-])c1 CHEMBL197442 Log Ki 0.7943 nM
COc1cccc(OC)c1OCCNCCOc1ccccc1OCc1ccccc1C CHEMBL382972 Log Ki 0.7943 nM
CCOc1cccc(OCC)c1OCCNCCOc1ccccc1OCc1ccccc1 CHEMBL1254742 pKi 0.7943 nM
COc1ccccc1N1CCN(CCn2c(=O)[nH]c3c(sc4ccc(NC(=O)CCCC(=O)NCc5ccccc5)cc43)c2=O)CC1 CHEMBL3298750 pKi 0.8318 nM
COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4cc(NC(C)=O)ccc4c3=O)C[C@@H]21 CHEMBL61598 Ki 0.84 nM
CNC[C@H](O)c1cccc(O)c1 CHEMBL1215 EC50 0.86 nM
COc1ccc(C(=O)N2CCN(c3nc(N)c4cc(OC)c(OC)cc4n3)[C@@H]3CCCC[C@@H]32)o1 CHEMBL242508 Log Ki 0.871 nM
COc1cc2nc(N3CCN(C(=O)c4ccc(C)o4)[C@H]4CCCC[C@H]43)nc(N)c2cc1OC CHEMBL242507 Log Ki 0.871 nM
COc1ccc(C(=O)N2CCN(c3nc(N)c4cc(OC)c(OC)cc4n3)[C@H]3CCCC[C@@H]32)o1 CHEMBL2261607 pKi 0.871 nM
COc1cc2nc(N3CCN(C(=O)c4ccc(C)o4)[C@H]4CCCC[C@@H]43)nc(N)c2cc1OC CHEMBL2261606 pKi 0.871 nM
CCCCCC(=O)N1CCN(c2nc(N)c3cc(OC)c(OC)cc3n2)[C@@H]2CCCC[C@@H]21 CHEMBL4127078 pKi 0.912 nM
COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4cccc(Cl)c4c3=O)C[C@@H]21 CHEMBL440865 Ki 0.92 nM
COc1cc2nc(N(C)CCCCCCN(C)C(=O)C3COc4ccccc4O3)nc(N)c2cc1OC CHEMBL561851 pKi 0.9333 nM
COc1ccccc1N1CCN(CCCCN2C(=O)c3ccccc3C2=O)CC1 CHEMBL8618 Ki 0.96 nM
c1c[nH]c(-c2ccccc2OCC2=NCCN2)c1 CHEMBL357129 Log EC50 1.0 nM
COc1cccc(OC)c1OCCNCCOc1ccccc1OCc1ccc(Cl)cc1 CHEMBL200446 Log Ki 1.0 nM
COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4cscc4c3=O)C[C@@H]21 CHEMBL445071 Ki 1.01 nM
COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4cccc(C)c4c3=O)C[C@@H]21 CHEMBL62110 Ki 1.04 nM
c1ccc2c(c1)C[C@]1(c3c[nH]cn3)C[C@H]21 CHEMBL1256414 pKi 1.047 nM
COc1cc2nc(N(C)CCSSCCN(C)C(=O)c3ccco3)nc(N)c2cc1OC CHEMBL29591 Log Ki 1.072 nM
COC(=O)[C@@H]1[C@H]2C[C@H]3c4[nH]c5ccccc5c4CCN3C[C@@H]2CC[C@@H]1O CHEMBL15245 Ki 1.1 nM
COc1cccc(OC)c1OCCNCC1CC(c2ccccc2)c2ccccc2S1 CHEMBL43905 Log Ki 1.148 nM
COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4ccccc4c3=O)C[C@@H]21 CHEMBL61491 Ki 1.16 nM
COc1cc2nc(N3CCN(C(=O)Cc4ccc5ccccc5c4)[C@H]4CCCC[C@H]43)nc(N)c2cc1OC CHEMBL4125846 pKi 1.175 nM
Cc1c(-c2ccccc2)oc2c(C(=O)NCCCN3CCN(c4ccccc4OCCCO[N+](=O)[O-])CC3)cccc2c1=O CHEMBL338029 Ki 1.2 nM
COc1ccccc1N1CCN(CCn2c(=O)[nH]c3sccc3c2=O)CC1 CHEMBL13735 Ki 1.22 nM
COc1cccc(OC)c1OCCNCC1CC(c2ccccc2)c2ccccc2C1=O CHEMBL44403 Log Ki 1.23 nM
COc1c(C)c(C)c(O)c(C)c1CN(C)CCOc1cc(C)c(O)cc1C(C)C CHEMBL25300 Log Ki 1.259 nM
COc1cc2nc(N3CCN(C(=O)CCCCC4CCSS4)CC3)nc(N)c2cc1OC CHEMBL178923 Log Ki 1.259 nM
COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(C)csc4c3=O)C[C@@H]21 CHEMBL60721 Ki 1.28 nM
O=S(=O)(c1ccc2cc[nH]c2c1)N1CCC[C@@H]1CCN1CCC(c2c[nH]c3ccccc23)CC1 CHEMBL430706 Log Ki 1.288 nM
COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(C)c(C)ccc4c3=O)C[C@@H]21 CHEMBL431720 Ki 1.32 nM
COc1cc2nc(N3CCN(C(=O)c4ccc(C(C)=O)o4)[C@H]4CCCC[C@H]43)nc(N)c2cc1OC CHEMBL242723 Log Ki 1.38 nM
COc1cc2nc(N3CCN(C(=O)c4ccc(C(C)=O)o4)[C@H]4CCCC[C@@H]43)nc(N)c2cc1OC CHEMBL2261608 pKi 1.38 nM
COc1cc2nc(N3CCN(C(=O)C4COc5ccccc5O4)[C@@H]4CCCC[C@@H]43)nc(N)c2cc1OC CHEMBL558890 pKi 1.413 nM
COc1ccc(Cl)cc1N1CCN(CCCNc2c(C(C)=O)c(-c3ccccc3)nn(C)c2=O)CC1 CHEMBL77618 Ki 1.44 nM
CCC(=O)c1c(-c2ccccc2)nn(C)c(=O)c1NCCN1CCN(c2ccccc2OC)CC1 CHEMBL78874 Ki 1.45 nM
COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4cc(C#N)ccc4c3=O)C[C@@H]21 CHEMBL62033 Ki 1.56 nM
COc1cc2nc(N3CCN(C(=O)CC(c4ccccc4)c4ccccc4)CC3)nc(N)c2cc1OC CHEMBL137903 Ki 1.57 nM
COc1ccc(C)cc1N1CCN(CCCNc2cc(=O)n(C)c(=O)n2C)CC1 CHEMBL76168 Ki 1.58 nM
CNC(=O)c1ccccc1NCC1=NCCN1 CHEMBL95523 Log EC50 1.585 nM
c1ccc(-c2ncco2)c(NCC2=NCCN2)c1 CHEMBL155326 Log EC50 1.622 nM
COc1cccc2c1CCC1CN(CCn3c(=O)[nH]c4ccsc4c3=O)CC21 CHEMBL2115086 Ki 1.63 nM
COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4ccsc4c3=O)C[C@@H]21 CHEMBL291839 Ki 1.63 nM
COC(=O)c1ccc2c(=O)n(CCN3C[C@@H]4CCc5c(OC)cccc5[C@@H]4C3)c(=O)[nH]c2c1 CHEMBL369154 Ki 1.64 nM
COc1ccccc1N1CCN(CCn2c(=O)[nH]c3c(sc4ccc(NC(=O)CCCN(C)C)cc43)c2=O)CC1 CHEMBL3298019 pKi 1.66 nM
COc1ccc(Cl)cc1N1CCN(CCNc2cc(-c3ccccc3)nn(C)c2=O)CC1 CHEMBL81486 Ki 1.76 nM
COc1ccccc1N1CCN(CCn2c(=O)[nH]c3c([nH]c4ccccc43)c2=O)CC1 CHEMBL301707 Log Ki 1.82 nM
COc1ccccc1N1CCN(CCn2c(=O)[nH]c3sc(-c4ccccc4)cc3c2=O)CC1 CHEMBL13903 Ki 1.86 nM
CSc1ccc(F)cc1NCC1=NCCN1 CHEMBL72768 Log EC50 1.862 nM
COc1ccc(C[C@@H](C)NCCOc2ccccc2OC(C)C)cc1S(N)(=O)=O CHEMBL1630938 pKi 1.905 nM
COc1ccccc1N1CCN(CCn2c(=O)[nH]c3c(sc4ccc(NC(=O)CCCC(=O)N(C)Cc5ccccc5)cc43)c2=O)CC1 CHEMBL3297829 pKi 1.905 nM
CSc1ccccc1NCC1=NCCN1 CHEMBL117248 Log EC50 1.995 nM
COc1cccc(COc2ccccc2OCCNCCOc2c(OC)cccc2OC)c1 CHEMBL427552 Log Ki 1.995 nM
COc1cc2nc(N3CCN(C(=O)OCc4ccccc4)[C@H](C(=O)NC(C)(C)C)C3)nc(N)c2cc1OC CHEMBL19476 Ki 2.0 nM
COc1ccccc1N1CCN(CCNc2cc(-c3ccccc3)nn(C)c2=O)CC1 CHEMBL311479 Ki 2.01 nM
COc1ccc(Cl)cc1N1CCN(CCCNc2cc(-c3ccccc3)nn(C)c2=O)CC1 CHEMBL78676 Ki 2.01 nM
COc1cc2nc(N3CCN(C(=O)c4ccco4)CC3)nc(N)c2cc1OC CHEMBL1558 Ki 2.033 nM
COc1ccc(C[C@@H](C)NCCOc2ccccc2OCc2ccccc2)cc1S(N)(=O)=O CHEMBL1630939 pKi 2.089 nM
COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4sccc4c3=O)C[C@@H]21 CHEMBL292881 Ki 2.11 nM
CSc1ccccc1NCC1=NCCN1 CHEMBL540542 Log EC50 2.188 nM
COc1cccc(OC)c1OCCNC[C@H]1COc2cccc(Cl)c2O1 CHEMBL2153555 pKi 2.188 nM
COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(OC)cccc4c3=O)C[C@@H]21 CHEMBL302203 Ki 2.27 nM
COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(C(C)C)c(OC)sc4c3=O)C[C@@H]21 CHEMBL291528 Ki 2.31 nM
COc1cccc(OC)c1OCCNC[C@H]1COc2cccc(F)c2O1 CHEMBL2153557 pKi 2.399 nM
COc1cccc(OC)c1OCCNCCOc1ccccc1OCc1ccccc1[N+](=O)[O-] CHEMBL200136 Log Ki 2.512 nM
O=C1CCCN1CCCCN1CCN(c2ccccc2Cl)CC1 CHEMBL3400597 EC50 2.53 nM
O=c1[nH]c2c([nH]c3ccccc32)c(=O)n1CCN1CCN(c2ccccc2Cl)CC1 CHEMBL57163 Log Ki 2.57 nM
COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4[nH]ccc4c3=O)C[C@@H]21 CHEMBL294098 Ki 2.58 nM
COc1ccccc1N1CCN(CCn2c(=O)[nH]c3c(sc4ccc(NC(=O)CCC(=O)NCc5ccccc5)cc43)c2=O)CC1 CHEMBL3298749 pKi 2.692 nM
COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4cc(Cl)ccc4c3=O)C[C@@H]21 CHEMBL60471 Ki 2.71 nM
COc1cccc(OC)c1OCCNC[C@H]1COc2cccc(OC)c2O1 CHEMBL2153553 pKi 2.754 nM
COc1cc2nc(N(C)CCCNC(=O)C3CCCO3)nc(N)c2cc1OC CHEMBL709 Ki 2.8 nM
COc1cccc(OC)c1OCCNCCOc1ccccc1Cc1ccccc1 CHEMBL42558 Log Ki 2.818 nM
COc1ccccc1C1CCN(CCn2c(=O)[nH]c3c([nH]c4ccccc43)c2=O)CC1 CHEMBL99761 Log Ki 2.884 nM
[2H]c1c([2H])c([2H])c([C@@H]2C[C@@H](N3CCN(C([2H])([2H])[2H])C(C)(C)C3)c3cc(Cl)ccc32)c([2H])c1[2H] CHEMBL5191141 Ki 2.9 nM
O=C1c2ccccc2C(=O)N1CCCCN1CCC(n2c(O)nc3ccccc32)CC1 CHEMBL311247 Ki 3.0 nM
COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4cnccc4c3=O)C[C@@H]21 CHEMBL432147 Ki 3.1 nM
COc1cc2nc(N3CCN(C(=O)c4ccc[nH]4)[C@H]4CCCC[C@H]43)nc(N)c2cc1OC CHEMBL389978 Log Ki 3.162 nM
C1=C(N2CCNCC2)c2nccn2Cc2ccccc21 CHEMBL1222552 pKi 3.162 nM
COc1cc2nc(N3CCN(C(=O)c4ccco4)[C@H](C(=O)NC(C)(C)C)C3)nc(N)c2cc1OC CHEMBL19826 IC50 3.2 nM
O=C1NCCN1CCN1CCC(c2cn(-c3ccc(F)cc3)c3ccc(Cl)cc23)CC1 CHEMBL12713 Activity 3.2 nM
COc1ccccc1N1CCN(CCNc2c(C(C)=O)c(-c3ccccc3)nn(C)c2=O)CC1 CHEMBL80641 Ki 3.29 nM
COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4ncccc4c3=O)C[C@@H]21 CHEMBL60722 Ki 3.31 nM
COc1cc2c(=O)n(CCN3C[C@@H]4CCc5c(OC)cccc5[C@@H]4C3)c(=O)n(C)c2cc1OC CHEMBL58862 Ki 3.31 nM
COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4cc([N+](=O)[O-])ccc4c3=O)C[C@@H]21 CHEMBL304215 Ki 3.33 nM
COC(=O)c1cc2[nH]c(=O)n(CCN3C[C@@H]4CCc5c(OC)cccc5[C@@H]4C3)c(=O)c2s1 CHEMBL293236 Ki 3.37 nM
Cc1ccccc1N1CCN(CCCCN2CCCC2=O)CC1 CHEMBL3400593 EC50 3.5 nM
CCC[C@H]1[C@@H]2c3ccccc3C[C@]12c1c[nH]cn1 CHEMBL1255724 pKi 3.548 nM
COc1ccc(SC)c(NCC2=NCCN2)c1 CHEMBL70691 Log EC50 3.631 nM
COc1ccccc1N1CCN(CCn2c(=O)[nH]c3sc(C)c(-c4ccccc4)c3c2=O)CC1 CHEMBL13754 Ki 3.7 nM
c1ccc(-c2ccno2)c(NCC2=NCCN2)c1 CHEMBL155327 Log EC50 3.715 nM
COc1ccc2[nH]c(=O)n(CCN3C[C@@H]4CCc5c(OC)cccc5[C@@H]4C3)c(=O)c2c1 CHEMBL61225 Ki 3.76 nM
CC(=O)c1c(-c2ccccc2)nn(C)c(=O)c1NCCN1CCN(c2ccccc2F)CC1 CHEMBL420205 Ki 3.77 nM
COc1ccccc1N1CCN(CCCNC(=O)c2cccc3c(=O)c(C)c(-c4ccccc4)oc23)CC1 CHEMBL278865 Ki 3.9 nM
COc1ccc(Cl)cc1N1CCN(CCNc2c(C(C)=O)c(-c3ccccc3)nn(C)c2=O)CC1 CHEMBL80458 Ki 3.95 nM
c1csc(-c2ccccc2OCC2=NCCN2)c1 CHEMBL143801 Log EC50 3.981 nM
COc1ccccc1N1CCN(CCCCN2C(=O)CC(c3ccccc3)CC2=O)CC1 CHEMBL1796033 pKi 3.981 nM
COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4cc(C)c(C)cc4c3=O)C[C@@H]21 CHEMBL60510 Ki 4.07 nM
COc1cccc2c(CCCN3CCN(c4ccccn4)CC3)cccc12 CHEMBL139505 Ki 4.21 nM
COc1cc2nc(N3CCN(C(=O)CCC(=O)c4ccccc4)CC3)nc(N)c2cc1OC CHEMBL424658 Ki 4.43 nM
COc1ccc(Cl)cc1N1CCN(CCn2c(C)nc3c([nH]c4ccccc43)c2=O)CC1 CHEMBL220515 Log Ki 4.467 nM
COc1ccccc1N1CCN(CCn2c(=O)c3c(-c4ccccc4)csc3n(C)c2=O)CC1 CHEMBL14213 Ki 4.47 nM
COc1ccccc1N1CCN(CCn2c(=O)[nH]c3scc(-c4ccccc4)c3c2=O)CC1 CHEMBL268758 Ki 4.66 nM
Cc1c(-c2ccccc2)oc2c(C(=O)NCCCN3CCN(c4ccccc4OCc4no[n+]([O-])c4C)CC3)cccc2c1=O CHEMBL338608 Ki 4.7 nM
CC1=C(C(=O)NCCCN2CCC(c3ccc(F)cc3)CC2)[C@@H](c2ccc(F)c(F)c2)N(C)C(=O)N1 CHEMBL90606 Ki 4.8 nM
Cc1ccc(N(CC2=NCCN2)c2cccc(O)c2)cc1 CHEMBL597 Ki 4.8 nM
CC(C)Oc1ccccc1N1CCN(CCN2C(=O)CC3(CCCC3)CC2=O)CC1 CHEMBL60583 Ki 4.97 nM
c1ccc(-c2ccoc2)c(OCC2=NCCN2)c1 CHEMBL142784 Log EC50 5.012 nM
c1ccc(-c2cc[nH]n2)c(NCC2=NCCN2)c1 CHEMBL277375 Log EC50 5.012 nM
c1ccc(-c2nc[nH]n2)c(NCC2=NCCN2)c1 CHEMBL17491 Log EC50 5.012 nM
O=c1[nH]c2ccccc2c(=O)n1CCCN1CCN(c2ccccc2OCC(F)(F)F)CC1 CHEMBL56863 Log Ki 5.012 nM
COc1cccc([N+](=O)[O-])c1OCCNCCOc1ccccc1OCc1ccccc1 CHEMBL1254743 pKi 5.012 nM
COc1cccc(C)c1OCCNCCOc1ccccc1OCc1ccccc1 CHEMBL1254829 pKi 5.012 nM
COc1ccccc1N1CCN(CCc2ccc3c(c2)OCO3)CC1 CHEMBL2220978 pKi 5.248 nM
CCOc1ccccc1N1CCN(CCc2ccc3c(c2)OCO3)CC1 CHEMBL3917716 pKi 5.37 nM
O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(c2cc(Cl)ccc2Cl)CC1 CHEMBL59262 Ki 5.38 nM
COc1cc2nc(N3CCN(C(=O)CC(=O)c4ccccc4)CC3)nc(N)c2cc1OC CHEMBL434228 Ki 5.43 nM
COc1ccc(C[C@@H](C)NCCOc2ccccc2OCC(F)(F)F)cc1S(N)(=O)=O CHEMBL1630940 pKi 5.495 nM
COc1ccccc1N1CCN(CCCNc2cc(-c3ccccc3)nn(C)c2=O)CC1 CHEMBL78785 Ki 5.51 nM
c1csc(-c2ccccc2NCC2=NCCN2)c1 CHEMBL346380 Log EC50 5.754 nM
COc1cccc(OC)c1OCCNC[C@H]1COc2ccccc2O1 CHEMBL215421 Log Ki 5.754 nM
COc1cccc(OC)c1OCCNC[C@H]1COc2ccccc2O1 CHEMBL1182155 pKi 5.754 nM
COc1cccc(OC)c1OCCNC[C@H]1COc2ccccc2O1 CHEMBL3741808 pKi 5.754 nM
O=C1CC2(CCCC2)CC(=O)N1CCN1CCN(c2cc(F)ccc2F)CC1 CHEMBL556313 Ki 5.88 nM
COc1cc2nc(N3CCN(C(=O)c4ccccn4)[C@H]4CCCC[C@H]43)nc(N)c2cc1OC CHEMBL242725 Log Ki 5.888 nM
CSc1cc(F)ccc1NCC1=NCCN1 CHEMBL306792 Log EC50 6.026 nM
CSc1ccc(C(F)(F)F)cc1NCC1=NCCN1 CHEMBL72724 Log EC50 6.026 nM
COc1cccc(OC)c1OCCNCC1C(=O)c2ccccc2CC1c1ccccc1 CHEMBL330599 Log Ki 6.11 nM
C[C@H]1c2ccccc2[C@H]2C[C@]21c1c[nH]cn1 CHEMBL1256609 pKi 6.166 nM
c1coc(-c2ccccc2NCC2=NCCN2)c1 CHEMBL152155 Log EC50 6.31 nM
O=c1[nH]cc(C(F)(F)F)c(=O)n1CCCN1CCN(c2ccccc2OCC(F)(F)F)CC1 CHEMBL301650 Log Ki 6.31 nM
COc1ccccc1COc1ccccc1OCCNCCOc1c(OC)cccc1OC CHEMBL198431 Log Ki 6.31 nM
CN1CCC(n2nc(Cc3ccc(Cl)cc3)c3ccccc3c2=O)CC1 CHEMBL1767156 pKi 6.31 nM
COc1ccccc1N1CCN(CCn2c(=O)[nH]c3c(sc4ccc(NC(=O)CCCC(=O)NCCc5ccccc5)cc43)c2=O)CC1 CHEMBL3298017 pKi 6.457 nM
COc1ccccc1N1CCN(CCn2c(C)nc3c(sc4ccc(NC(=O)CCCC(=O)NCCc5ccccc5)cc43)c2=O)CC1 CHEMBL3298023 pKi 6.457 nM
COc1cc2[nH]c(=O)n(CCN3C[C@@H]4CCc5c(OC)cccc5[C@@H]4C3)c(=O)c2cc1OC CHEMBL291303 Ki 6.46 nM
Cc1c(-c2ccccc2)oc2c(C(=O)NCCCN3CCN(c4ccccc4OCc4no[n+]([O-])c4C#N)CC3)cccc2c1=O CHEMBL125989 Ki 6.5 nM
COc1cccc(OC)c1OCCNCC1Oc2ccccc2CC1c1ccccc1 CHEMBL318257 Log Ki 6.51 nM
Cc1ccc(C(C(=O)NCCCN2CCN(c3ccccc3C)CC2)c2ccc(C)cc2)cc1 CHEMBL415887 Ki 6.6 nM
COc1ccccc1N1CCN(CC2OCC(c3ccccc3)(c3ccccc3)O2)CC1 CHEMBL1242352 pKi 6.761 nM
COc1ccccc1N1CCN(CC2COC(c3ccccc3)(c3ccccc3)O2)CC1 CHEMBL1946777 pKi 6.761 nM
CS(=O)(=O)c1ccc2c(c1)S(=O)(=O)N(CCCCN1CCC(n3c(=O)oc4ccccc43)CC1)C2=O CHEMBL81173 Ki 6.8 nM
COc1cccc(OC)c1OCCNCC1C(=O)c2ccccc2OC1c1ccccc1 CHEMBL99489 Log Ki 6.84 nM
COc1cccc(OC)c1OCCNCC1=Cc2ccccc2OC1c1ccccc1 CHEMBL329035 Log Ki 6.84 nM
COc1cccc(OC)c1CCCNCCOc1ccccc1OCc1ccccc1 CHEMBL1254659 pKi 6.918 nM
COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(sc5cccnc54)c3=O)C[C@@H]21 CHEMBL40650 Ki 6.95 nM
O=C(CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1)c1ccc(F)cc1 CHEMBL267930 Log Ki 7.079 nM
COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(C)c(OC)sc4c3=O)C[C@@H]21 CHEMBL294027 Ki 7.14 nM
O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCC(n2c(=O)oc3cc(F)ccc32)CC1 CHEMBL83272 Ki 7.3 nM
COc1cc2nc(N3CCN(C(=S)Nc4ccc(-c5c6ccc(=O)cc-6oc6cc(O)ccc56)c(C(=O)O)c4)CC3)nc(N)c2cc1OC CHEMBL3582271 Ki 7.3 nM
COc1cc2nc3c(c(N)c2cc1OC)CCC(CNC(=O)c1ccccc1C(F)(F)F)C3 CHEMBL145785 Log Ki 7.413 nM
COc1ccccc1N1CCN(CCn2c(=O)[nH]c3c(sc4ccc(NC(=O)CCCN(C)Cc5ccccc5)cc43)c2=O)CC1 CHEMBL3298018 pKi 7.413 nM
COc1cc2nc(N3CCC[C@H](NC(=O)[C@@H]4COc5ccccc5O4)C3)nc(N)c2cc1OC CHEMBL4160032 pKi 7.413 nM
COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCN(c3ccccc3)CC2)C1c1ccc(F)c(F)c1 CHEMBL342731 Ki 7.5 nM
COc1ccccc1N1CCN(CCn2c(C)nc3c(sc4ccc(NC(=O)CCCNC(=O)Cc5ccccc5)cc43)c2=O)CC1 CHEMBL3298024 pKi 7.586 nM
O=C1CC2(CCCC2)CC(=O)N1CCN1CCC(c2ccccc2Cl)CC1 CHEMBL56292 Ki 7.76 nM
COc1cccc2c1CCCC2CCCN1CCN(c2ccccn2)CC1 CHEMBL444590 Ki 7.88 nM
CN1C=C(C(=O)NCCCN2CCC(c3ccc(F)cc3C#N)CC2)[C@@H](c2ccc(F)c(F)c2)NC1=O CHEMBL90086 Ki 7.9 nM
COc1cccc(Cl)c1OCCNCCOc1ccccc1OCc1ccccc1 CHEMBL1254828 pKi 7.943 nM
COc1ccccc1N1CCN(CCCCN2C(=O)CC(C)(c3ccccc3)CC2=O)CC1 CHEMBL1796046 pKi 7.943 nM
CCCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2cnccc2c1=O CHEMBL2146806 pKi 7.943 nM
O=C1CC2(CCCC2)CCN1CCN1CCN(c2cc(Cl)ccc2Cl)CC1 CHEMBL301224 Ki 7.95 nM
COc1ccc(Cl)cc1N1CCN(CCCNc2c(C(C)=O)c(C)nn(C)c2=O)CC1 CHEMBL80599 Ki 8.04 nM
COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4cccnc4c3=O)C[C@@H]21 CHEMBL299907 Ki 8.2 nM
COc1ccccc1OCCN(C)CCN1C(=O)CC2(CCCC2)CC1=O CHEMBL417939 Ki 8.21 nM
COc1ccccc1N1CCN(CC2COC3(CCN(S(=O)(=O)c4ccc(C)cc4)CC3)O2)CC1 CHEMBL3342867 pKi 8.318 nM
COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCN(c3cccc(Cl)c3)CC2)C1c1ccc(F)c(F)c1 CHEMBL145443 Ki 8.4 nM
COc1cc2nc(N3CCN(C(=O)COc4ccccc4OC)CC3)nc(N)c2cc1OC CHEMBL343283 Ki 8.56 nM
CCOc1ccccc1N1CCN(CCCNC(=O)N2C(=O)NC(C)=C(C(=O)OC)C2c2ccc(F)c(F)c2)CC1 CHEMBL142251 Ki 8.8 nM
COc1cc2nc3c(c(N)c2cc1OC)CCC(CNC(=O)c1ccc(C(F)(F)F)cc1)C3 CHEMBL143026 Log Ki 8.913 nM
COc1ccccc1N1CCN(CCn2c(=O)[nH]c3c(sc4ccccc43)c2=O)CC1 CHEMBL220781 Log Ki 8.913 nM
CCC[C@H]1c2ccccc2[C@H]2C[C@]21c1c[nH]cn1 CHEMBL1255616 pKi 8.913 nM
COc1ccccc1N1CCN(CC2CCC(c3ccccc3)(c3ccccc3)O2)CC1 CHEMBL1946780 pKi 8.913 nM
COc1cc2nc(N3CCN(C(=O)COc4c(OC)cccc4OC)CC3)nc(N)c2cc1OC CHEMBL335731 Ki 9.05 nM
COc1ccccc1N1CCN(CCn2c(=O)[nH]c3scc(-c4cccc(C)c4)c3c2=O)CC1 CHEMBL13856 Ki 9.09 nM
COc1cc2nc(N3CCN(C(C)=O)[C@H]4CCCC[C@H]43)nc(N)c2cc1OC CHEMBL4128311 pKi 9.12 nM
COc1cc2[nH]c(=O)n(CCN3C[C@@H]4CCc5c(OC)cccc5[C@@H]4C3)c(=O)c2cc1Cl CHEMBL62109 Ki 9.27 nM
COc1ccccc1N1CCN(C[C@H]2CO[C@@](CN3C(=O)CC4(CCCC4)CC3=O)(c3ccccc3)O2)CC1 CHEMBL1242912 pKi 9.333 nM
CN(CC1CCCCC1)[C@H]1C2C3CC4C5C3CC2C5C41 CHEMBL2432063 Ki 9.4 nM
COc1ccccc1N1CCN(CCCCCn2cc(CCCC(=O)O)c3ccccc32)CC1 CHEMBL4785526 IC50 9.8 nM
O=C1CC2(CCCC2)CC(=O)N1CCN1CCN(c2cc(Cl)ccc2Cl)CC1 CHEMBL56438 Ki 9.9 nM
c1coc(-c2ccccc2OCC2=NCCN2)c1 CHEMBL279136 Log EC50 10.0 nM
CSc1ccc2c(c1)C(=O)N(CCCCN1CCC(n3c(=O)oc4ccccc43)CC1)S2(=O)=O CHEMBL309518 Ki 10.0 nM
Cc1c[nH]c(=O)n(CCCCN2CCN(c3ccc(F)cc3OCC(F)(F)F)CC2)c1=O CHEMBL55695 Log Ki 10.0 nM
COc1ccccc1N1CCN(C[C@@H]2CO[C@@](CN3C(=O)CC4(CCCC4)CC3=O)(c3ccccc3)O2)CC1 CHEMBL1241557 pKi 10.0 nM
COCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2cnccc2c1=O CHEMBL2146801 pKi 10.0 nM
CN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O CHEMBL1767136 pKi 10.0 nM
CN1CCN(C2=Nc3cc(Cl)ccc3Nc3ccccc32)CC1 CHEMBL42 pKi 10.0 nM
Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2 CHEMBL85 pKi 10.0 nM
COc1ccccc1N1CCN(CCn2c(=O)[nH]c3c(sc4ccc(NC(=O)c5ccccc5)cc43)c2=O)CC1 CHEMBL3298745 pKi 10.0 nM
COCCNC(=O)CCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O CHEMBL5272034 pKi 10.0 nM
O=C1CC2(CCCC2)CC(=O)N1CCN1CCN(c2cc(F)ccc2Cl)CC1 CHEMBL293539 Ki 10.05 nM
CCOc1ccccc1N1CCN(CCc2ccc(OC)cc2)CC1 CHEMBL3930616 pKi 10.23 nM
COc1ccc(CCN2CCN(c3ccccc3OC(C)C)CC2)cc1OC CHEMBL3920110 pKi 10.47 nM
COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4ccncc4c3=O)C[C@@H]21 CHEMBL291588 Ki 10.57 nM
COc1ccc(Cl)cc1N1CCN(CCn2c(=O)[nH]c3c([nH]c4ccccc43)c2=O)CC1 CHEMBL386005 Log Ki 10.72 nM
COc1ccc(-c2ccccc2)cc1OCCNC[C@H]1COc2ccccc2O1 CHEMBL214694 Log Ki 10.96 nM
[2H]c1c([2H])c([2H])c([C@@H]2C[C@@H](N3CCNC(C)(C)C3)c3cc(Cl)ccc32)c([2H])c1[2H] CHEMBL5201983 Ki 11.0 nM
COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4cc(-c5ccccc5)sc4c3=O)C[C@@H]21 CHEMBL58105 Ki 11.3 nM
CCCO[C@H]1c2ccccc2[C@H]2C[C@]21c1c[nH]cn1 CHEMBL1256566 pKi 11.48 nM
O=C1CC2(CCCC2)CC(=O)N1CCN1CCCN(c2ccccc2Cl)CC1 CHEMBL298595 Ki 11.5 nM
O=c1[nH]c2c([nH]c3ccccc32)c(=O)n1CCN1CCN(c2ccccc2O)CC1 CHEMBL99879 Log Ki 11.75 nM
COc1cc2nc3c(c(N)c2cc1OC)CCC(CNC(=O)c1ccco1)C3 CHEMBL144286 Log Ki 12.3 nM
COc1cccc(OC)c1OCCNCC1Cc2ccccc2C(c2ccccc2)C1 CHEMBL42231 Log Ki 12.3 nM
O=C1c2ccccc2C(=O)N1Cc1ccc(CCN2CCN(c3ccccn3)CC2)cc1 CHEMBL3739533 IC50 12.57 nM
CC(C)CNC(=O)c1ccccc1NCC1=NCCN1 CHEMBL95565 Log EC50 12.59 nM
COc1ccc(Cl)cc1N1CCN(CCCNc2nccc(C(N)=O)n2)CC1 CHEMBL24981 Log Ki 12.59 nM
c1ccc(-c2ccns2)c(OCC2=NCCN2)c1 CHEMBL142387 Log EC50 12.59 nM
COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4nccnc4c3=O)C[C@@H]21 CHEMBL62206 Ki 12.59 nM
COc1cc2nc3c(c(N)c2cc1OC)CCC(CNC(=O)c1cccc(C(F)(F)F)c1)C3 CHEMBL2112853 Log Ki 12.59 nM
CCOc1ccccc1OCCNCCOc1ccccc1OCc1ccccc1 CHEMBL1254914 pKi 12.59 nM
COCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O CHEMBL2146803 pKi 12.59 nM
COc1ccccc1OCCN1CCC(CNS(=O)(=O)c2cc(Cl)ccc2F)CC1 CHEMBL3937911 EC50 12.65 nM
CC(C)Oc1ccccc1N1CCN(CCc2ccc3c(c2)OCO3)CC1 CHEMBL3938038 pKi 12.88 nM
COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCN(c3ccccc3[N+](=O)[O-])C[C@H]2C)C1c1ccc(F)c(F)c1 CHEMBL341849 Ki 13.0 nM
CC(CN1CCN(c2cc(Cl)ccc2Cl)CC1)N1C(=O)CC2(CCCC2)CC1=O CHEMBL300152 Ki 13.11 nM
COC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 CHEMBL5483012 Log Ki 13.49 nM
CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 CHEMBL91022 Log Ki 13.49 nM
Cn1nc(Cl)c2cn3nc(NCCN4CCN(c5ccccc5Cl)CC4)ccc3c2c1=O CHEMBL49851 Ki 13.6 nM
O=C1CC2(CCCC2)CC(=O)N1CCCN1CCN(c2cc(Cl)ccc2Cl)CC1 CHEMBL55319 Ki 13.61 nM
CCSc1ccccc1NCC1=NCCN1 CHEMBL540035 Log EC50 13.8 nM
COc1ccccc1N1CCN(CCn2cnc3c4ccccc4nc-3c2O)CC1 CHEMBL433203 Log Ki 13.8 nM
COc1cccc(CCN2CCN(c3ccccc3OC(C)C)CC2)c1 CHEMBL3946843 pKi 13.8 nM
COCC1=C(C(=O)OC)[C@H](c2ccc(F)c(F)c2)N(C(=O)N[C@@H]2CC[C@@H](N3CCN(c4ccccc4C#N)CC3)C2)C(=O)N1 CHEMBL56974 Ki 14.0 nM
O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCC(n2c(=O)oc3ccccc32)CC1 CHEMBL311890 Ki 14.0 nM
COc1ccccc1OCCN1CCC(CNS(=O)(=O)c2cccc(Cl)c2F)CC1 CHEMBL3895815 EC50 14.15 nM
CCOc1ccccc1N1CCN(CCn2c(=O)[nH]c3c([nH]c4ccccc43)c2=O)CC1 CHEMBL317555 Log Ki 14.45 nM
COc1cc2nc(N3CCN(C(=O)C(C)Oc4c(OC)cccc4C(C)C)CC3)nc(N)c2cc1OC CHEMBL136458 Ki 14.7 nM
c1ccc2c(c1)[C@H]1C[C@@]1(c1c[nH]cn1)C21CC1 CHEMBL1255617 pKi 14.79 nM
COc1ccc(CCN2CCN(c3ccccc3OC(C)C)CC2)cc1 CHEMBL3976144 pKi 14.79 nM
COc1ccccc1OCCNCCC1COC(c2ccccc2)(c2ccccc2)O1 CHEMBL4458714 pKi 14.79 nM
COCC1=C(C(=O)OC)[C@H](c2ccc(F)c(F)c2)N(C(=O)N[C@H]2CC[C@H](N3CCN(c4ccccc4C#N)CC3)C2)C(=O)N1 CHEMBL278716 Ki 15.0 nM
CCOC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 CHEMBL142957 Ki 15.0 nM
CCc1sc2ccc(Cl)c3c2c1CN(C)CC3 CHEMBL123448 Ki 15.0 nM
COc1ccc2c(c1)C(=O)N(CCCCN1CCC(n3c(=O)oc4ccccc43)CC1)S2(=O)=O CHEMBL83340 Ki 15.0 nM
COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCN(c3ccccc3Cl)CC2)C1c1ccc(F)c(F)c1 CHEMBL142398 Ki 15.0 nM
COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCN(c3ccccc3C#N)CC2)C1c1ccc(F)c(F)c1 CHEMBL145190 Ki 15.0 nM
CC(C)Oc1ccccc1N1CCN(C2CCC(N3C(=O)c4ccc5ccccc5c4C3=O)CC2)CC1 CHEMBL243864 Ki 15.0 nM
COc1ccccc1N1CCN(CCNc2ccc3c4c(=O)n(C)nc(Cl)c4cn3n2)CC1 CHEMBL301078 Ki 15.2 nM
COc1cc2ncn(CCN3C[C@@H]4CCc5c(OC)cccc5[C@@H]4C3)c(=O)c2cc1OC CHEMBL445325 Ki 15.3 nM
COc1ccccc1OCCN1CCC(CNS(=O)(=O)c2cccc(Cl)c2)CC1 CHEMBL3956998 EC50 15.5 nM
Cn1nc(Cl)c2cn3nc(NCCN4CCN(c5ccccc5)CC4)ccc3c2c1=O CHEMBL51074 Ki 15.6 nM
COc1ccccc1N1CCN(CCCn2c(=O)[nH]c3scc(-c4ccccc4)c3c2=O)CC1 CHEMBL14199 Ki 15.8 nM
O=C1CC2(C=CN1CCN1CCN(c3cc(Cl)ccc3Cl)CC1)CCCC2 CHEMBL292366 Ki 15.84 nM
COc1ccc(CCN2CCC(c3nc(COCC(F)(F)F)c(-c4ccc(F)cc4)o3)CC2)cc1S(N)(=O)=O CHEMBL267336 Log Ki 15.85 nM
CC(C)(Cc1c[nH]c2ccc(Cl)cc12)NCCOc1ccccc1OCC1CC1 CHEMBL88272 Log Ki 15.85 nM
c1ccc(-c2ccsc2)c(OCC2=NCCN2)c1 CHEMBL422477 Log EC50 15.85 nM
Cc1[nH]c(=O)n(CCCN2CCN(c3ccccc3OCC(F)(F)F)CC2)c(=O)c1C CHEMBL292189 Log Ki 15.85 nM
Cc1c[nH]c(=O)n(CCN2CCN(c3ccc(F)cc3OCC(F)(F)F)CC2)c1=O CHEMBL293149 Log Ki 15.85 nM
COc1ccc2ccccc2c1OCCNC[C@H]1COc2ccccc2O1 CHEMBL217469 Log Ki 15.85 nM
COc1cccc(OC)c1[S+]([O-])CCNCCOc1ccccc1OCc1ccccc1 CHEMBL1254660 pKi 15.85 nM
Cc1ccc(Cc2nn(C[C@H]3CCCN3C)c(=O)c3ccccc23)cc1 CHEMBL1767141 pKi 15.85 nM
CCCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O CHEMBL2146802 pKi 15.85 nM
CCOc1ccccc1N1CCN(CCc2ccc(OC)c(OC)c2)CC1 CHEMBL3902626 pKi 15.85 nM
c1cnc2c(N3CCN(CCc4ccc(OCCCN5CCCCCC5)cc4)CC3)cccc2c1 CHEMBL3947980 pKi 15.85 nM
COc1ccccc1OCCNCC1CCOC(c2ccccc2)(c2ccccc2)O1 CHEMBL4467585 pKi 15.85 nM
CCC(=O)NCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O CHEMBL5270515 pKi 15.85 nM
Cc1c(-c2ccccc2)oc2c(C(=O)NCCCN3CCN(c4ccccc4OCc4no[n+]([O-])c4C(N)=O)CC3)cccc2c1=O CHEMBL125365 Ki 15.9 nM
COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCN(c3ccccc3O)CC2)C1c1ccc(F)c(F)c1 CHEMBL141821 Ki 16.0 nM
COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(C)cc(C)cc4c3=O)C[C@@H]21 CHEMBL291769 Ki 16.28 nM
CC[C@H]1[C@@H]2c3ccccc3C[C@]12c1c[nH]cn1 CHEMBL1255723 pKi 16.6 nM
COc1ccccc1N1CCN(CC2COC3(CCN(Cc4ccccc4)CC3)O2)CC1 CHEMBL3342853 pKi 16.6 nM
COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCN(c3ccc(Cl)cc3)CC2)C1c1ccc(F)c(F)c1 CHEMBL142307 Ki 17.0 nM
COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCN(c3ccccc3C)CC2)C1c1ccc(F)c(F)c1 CHEMBL344525 Ki 17.0 nM
N#Cc1ccc(Cl)cc1N1CCN(CCN2C(=O)CC3(CCCC3)CC2=O)CC1 CHEMBL57868 Ki 17.01 nM
COc1ccc(Cl)cc1N1CCN(CCn2c(C)nc3c(sc4ccccc43)c2=O)CC1 CHEMBL222896 Log Ki 17.38 nM
COc1ccccc1N1CCN(CCn2c(C)nc3c(sc4ccccc43)c2=O)CC1 CHEMBL220221 Log Ki 17.38 nM
COc1cccc(-c2ccccc2)c1OCCNC[C@H]1COc2ccccc2O1 CHEMBL215151 Log Ki 17.78 nM
CC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)CC2)=C(COCCN)N1 CHEMBL95548 Ki 17.9 nM
COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCN(c3ccccc3OC)CC2)C1c1ccc(F)c(F)c1 CHEMBL146654 Ki 18.0 nM
CC(C)Oc1ccccc1N1CCN(C2CCC(N3C(=O)c4cccc(F)c4C3=O)CC2)CC1 CHEMBL243694 Ki 18.0 nM
COc1ccccc1N1CCN(C[C@@H]2CO[C@@](CN3CCCCCC3=O)(c3ccccc3)O2)CC1 CHEMBL1242633 pKi 18.2 nM
N=CCC(O)CC1CCN(c2ccccc2Oc2ccccc2)CC1 CHEMBL140450 Log Ki 18.62 nM
COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 CHEMBL142383 Ki 19.0 nM
Cc1ccccc1CN1CCC(N2CCC(n3c(=O)[nH]c4ccccc43)CC2)CC1 CHEMBL522460 Ki 19.0 nM
Cc1ccc2nccc(NCCNc3ccnc4ccc(C)cc34)c2c1 CHEMBL3343976 Ki 19.0 nM
O=C(c1ccc(F)cc1)C1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc3cc[nH]c3c2)CC1 CHEMBL114345 Log Ki 19.05 nM
COc1ccc2c(c1OCCNC[C@H]1COc3ccccc3O1)CCCC2 CHEMBL383938 Log Ki 19.05 nM
COc1ccccc1N1CCN(CCn2c(C)nc3c(sc4ccc(NC(=O)CCCC(=O)NCc5ccccc5)cc43)c2=O)CC1 CHEMBL3298022 pKi 19.05 nM
O=C1c2ccccc2C(=O)N1Cc1ccc(CCN2CCN(c3ccc(C(F)(F)F)cc3)CC2)cc1 CHEMBL3742253 IC50 19.69 nM
C[C@H](Cc1cc2c(c(C(N)=O)c1)N(CCCO)CC2)NCCOc1ccccc1OCC(F)(F)F CHEMBL24778 Log Ki 19.95 nM
C=Cc1sc2ccc(Cl)c3c2c1CN(C)CC3 CHEMBL25467 Log Ki 19.95 nM
c1ccc(-c2nccs2)c(OCC2=NCCN2)c1 CHEMBL142871 Log EC50 19.95 nM
CC(C)Oc1ccccc1OCCNCC1COC(c2ccccc2)(c2ccccc2)O1 CHEMBL1078773 pKi 19.95 nM
COc1ccccc1OCCNCCOc1ccccc1OCc1ccccc1 CHEMBL1254915 pKi 19.95 nM
CN1CCC[C@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O CHEMBL1767154 pKi 19.95 nM
COc1ccccc1N1CCN(CCCCN2C(=O)CC3(CCc4ccccc43)CC2=O)CC1 CHEMBL1796050 pKi 19.95 nM
CCCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ncccc2c1=O CHEMBL2146810 pKi 19.95 nM
COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1 CHEMBL142635 pKi 19.95 nM
COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCC(c3ccc(F)cc3)(c3ccc(F)cc3)CC2)C1c1ccc(F)c(F)c1 CHEMBL342126 Ki 20.0 nM
Cc1ccc2c(c1)C(=O)N(CCCCN1CCC(n3c(=O)oc4ccccc43)CC1)S2(=O)=O CHEMBL81006 Ki 20.0 nM
CC1=C(C(=O)NCCCN2CCC(c3ccc(F)cc3)CC2)[C@@H](c2ccc(F)c(F)c2)N(C)C(=O)N1C CHEMBL90420 Ki 20.0 nM
O=C1CC2(C=CN1CCN1CCN(c3ccccc3Cl)CC1)CCCC2 CHEMBL299253 Ki 20.25 nM
COc1ccccc1N1CCN(CCCNc2c(C(C)=O)c(-c3ccccc3)nn(C)c2=O)CC1 CHEMBL80260 Ki 20.28 nM
C[N+](C)(CCOc1ccccc1)CC1COC(c2ccccc2)(c2ccccc2)O1 CHEMBL37212 Log Ki 20.42 nM
COc1ccccc1N1CCN(CCn2c(C)nc3c4ccccc4nc-3c2O)CC1 CHEMBL99142 Log Ki 20.89 nM
COc1cccc(OC)c1OCCNC[C@@H]1Oc2ccccc2O[C@H]1c1ccc(C)cc1 CHEMBL72657 Ki 21.08 nM
COc1ccccc1OCCNC[C@@H]1COCC(c2ccccc2)(c2ccccc2)O1 CHEMBL493486 pKi 21.88 nM
COc1ccc2c(c1OCCNC[C@H]1COc3ccccc3O1)OCC2 CHEMBL2419771 pKi 21.88 nM
COc1ccccc1N1CCN(CCn2nc(-c3ccccc3)c(C(C)=O)c(N)c2=O)CC1 CHEMBL301726 Ki 22.1 nM
COc1cc2nc(N3CCN(C(=O)C4COc5ccccc5O4)[C@H]4CCCC[C@@H]43)nc(N)c2cc1OC CHEMBL549764 pKi 22.39 nM
CC(C)Oc1ccccc1N1CCN(C2CCC(N3C(=O)c4ccncc4C3=O)CC2)CC1 CHEMBL243229 Ki 22.4 nM
COc1ccccc1N1CCN(CC2COCC(c3ccccc3)(c3ccccc3)O2)CC1 CHEMBL4466677 pKi 22.91 nM
Cc1ccc(C(C(=O)NCCCN2CCN(c3ccccc3)CC2)c2ccc(C)cc2)cc1 CHEMBL435576 Ki 23.0 nM
COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCN(c3ccccc3[N+](=O)[O-])CC2)C1c1ccc(F)c(F)c1 CHEMBL145843 Ki 23.0 nM
Cc1noc(C)c1S(=O)(=O)Nc1ccc2c(c1)C(=O)CC1(CCN(CCc3cccc4ccccc34)CC1)O2 CHEMBL101610 Ki 24.0 nM
O=C1CC2(CCN(CCc3cccc4ccccc34)CC2)Oc2ccc(NS(=O)(=O)Cc3ccccc3)cc21 CHEMBL322688 Ki 24.0 nM
O=C1c2cc(Cl)ccc2S(=O)(=O)N1CCCCN1CCC(n2c(=O)oc3ccccc32)CC1 CHEMBL313990 Ki 24.0 nM
O=C1NC=C(C(=O)NCCCN2CCC(c3ccc(F)cc3)CC2)[C@@H](c2ccc(F)c(F)c2)N1 CHEMBL94167 Ki 24.0 nM
O=C(NC1CCN(CCc2c[nH]c3ccccc23)CC1)c1ccccc1 CHEMBL279516 Ki 25.0 nM
COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCN(c3ccccc3C(=O)OC)CC2)C1c1ccc(F)c(F)c1 CHEMBL145338 Ki 25.0 nM
COC(=O)N1C(=O)N(C)C(C)=C(C(=O)NCCCN2CCC(c3ccc(F)cc3)CC2)[C@H]1c1ccc(F)c(F)c1 CHEMBL93623 Ki 25.0 nM
COc1cc2nc(N3CCN[C@H](C(=O)NC(C)(C)C)C3)nc(N)c2cc1OC CHEMBL19376 Ki 25.0 nM
O=C(N(CCN1CCN(c2ccccc2O)CC1)c1ccccn1)C12C3C4C1C1C2C3C41I CHEMBL1774995 Ki 25.0 nM
COC(=O)C1=C(C)NC(C)=C(C(=O)OCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)[C@H]1c1cccc([N+](=O)[O-])c1 CHEMBL405355 Ki 25.01 nM
CCCCOC(=O)c1ccccc1NCC1=NCCN1 CHEMBL99559 Log EC50 25.12 nM
COC(=O)C1=C(C)NC(C)=C(C(=O)OCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)[C@@H]1c1cccc([N+](=O)[O-])c1 CHEMBL2051956 Log Ki 25.12 nM
CSc1ccccc1NCc1c[nH]cn1 CHEMBL118055 Log EC50 25.12 nM
CN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2cnccc2c1=O CHEMBL2146805 pKi 25.12 nM
CCOc1ccccc1N1CCN(CCc2cccc(OC)c2)CC1 CHEMBL3947302 pKi 25.12 nM
COc1cc2nc(N3CCC[C@@H](NC4=CC(=O)c5ccccc5C4=O)C3)nc(N)c2cc1OC CHEMBL4171491 pKi 25.12 nM
c1ccc(OCCNCCOC(c2ccccc2)c2ccccc2)cc1 CHEMBL4462600 pKi 25.12 nM
N#Cc1cc(F)ccc1C1CCN(CCCNC(=O)C2=CNC(=O)N[C@@H]2c2ccc(F)c(F)c2)CC1 CHEMBL94188 Ki 26.0 nM
COc1cccc2c1CCCC2CCCNCCOc1ccccn1 CHEMBL344432 Ki 26.4 nM
Cc1ccc(Cl)cc1N1CCN(CCN2C(=O)CC3(CCCC3)CC2=O)CC1 CHEMBL55654 Ki 26.6 nM
Cn1c(=O)cnn(CCCCN2CCN(c3ccccc3OCCF)CC2)c1=O CHEMBL2413153 Ki 26.8 nM
COc1ccccc1N1CCN(CCCn2c(C)nc3c4ccccc4nc-3c2O)CC1 CHEMBL316677 Log Ki 26.92 nM
COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 CHEMBL143940 Ki 27.0 nM
COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C1c1ccc2nonc2c1 CHEMBL142743 Ki 27.0 nM
CCc1nc2c3ccccc3nc-2c(O)n1CCCN1CCN(c2ccccc2OC)CC1 CHEMBL99979 Log Ki 27.54 nM
COc1cccc(OC)c1OCCNC[C@H]1C[C@H](c2ccccc2)c2ccccc2S1 CHEMBL40325 Log Ki 27.54 nM
COc1ccccc1OCCNC[C@H]1CO[C@H](C(c2ccccc2)c2ccccc2)O1 CHEMBL4570387 pKi 27.54 nM
COCC1=C(C(=O)OC)[C@H](c2ccc(F)c(F)c2)N(C(=O)N[C@@H]2CC[C@H](N3CCN(c4ccccc4C#N)CC3)C2)C(=O)N1 CHEMBL300766 Ki 28.0 nM
c1ccc2c(NCCNc3ccnc4ccccc34)ccnc2c1 CHEMBL3343975 Ki 28.0 nM
COc1ccccc1N1CCN(CCn2c(=O)[nH]c3c(sc4ccc(NC(=O)Cc5ccccc5)cc43)c2=O)CC1 CHEMBL3298746 pKi 28.18 nM
COc1ccc2ccoc2c1OCCNC[C@H]1COc2ccccc2O1 CHEMBL2419769 pKi 28.84 nM
Cc1ccc(N2CCN(CCc3ccc(CN4C(=O)c5ccccc5C4=O)cc3)CC2)cc1 CHEMBL3740019 IC50 28.91 nM
COc1cc(N)c(C(=O)NCCN2C[C@@H]3CCc4c(OC)cccc4[C@@H]3C2)cc1OC CHEMBL58612 Ki 29.1 nM
CCN(CC)c1ccc2cc(-n3cc(CN4CCN(c5nc(N)c6cc(OC)c(OC)cc6n5)CC4)nn3)c(=O)oc2c1 CHEMBL3582272 Ki 29.9 nM
COCC1=C(C(=O)OC)C(c2ccc(F)c(F)c2)N(C(=O)NCCCN2CCC(C#N)(c3ccc(F)cc3)CC2)C(=O)N1 CHEMBL144933 Ki 30.0 nM
CS(=O)(=O)c1ccccc1CCNCCOc1cc(F)ccc1Cl CHEMBL4214499 Ki 30.0 nM
c1ccc(-c2ccccc2NCC2=NCCN2)nc1 CHEMBL154298 Log EC50 30.2 nM
O=S(=O)(c1ccc2cc[nH]c2c1)N1CCC[C@@H]1CCN1CCC(Oc2ccc(F)cc2)CC1 CHEMBL413707 Log Ki 30.2 nM
O=C1CC(c2ccccc2)CC(=O)N1CCCCN1CCN(c2ccccc2Cl)CC1 CHEMBL1796034 pKi 30.2 nM
COc1ccccc1N1CCN(CCn2c(C)nc3c(sc4ccc(NC(=O)Cc5ccccc5)cc43)c2=O)CC1 CHEMBL3298021 pKi 30.2 nM
COc1cccc(OC)c1OCCNC[C@H]1COc2cccc(O)c2O1 CHEMBL2153551 pKi 30.9 nM
COc1ccccc1OCCNCC[C@H]1CO[C@H](C(c2ccccc2)c2ccccc2)O1 CHEMBL4551941 pKi 30.9 nM
CC(C)Oc1ccccc1N1CCN([C@H]2CC[C@H](NS(=O)(=O)c3ccccc3C#N)CC2)CC1 CHEMBL234680 Ki 31.0 nM
CN1CCN2c3c(cccc31)[C@@H]1CN(CCCC(=O)c3ccc(F)cc3)CC[C@@H]12 CHEMBL3233142 Ki 31.0 nM
COc1ccccc1N1CCN(CCn2nc(-c3ccccc3)c3c(C)onc3c2=O)CC1 CHEMBL303464 Ki 31.1 nM
Cc1c[nH]c(=O)n(CCCN2CCN(c3ccccc3OCC(F)(F)F)CC2)c1=O CHEMBL56331 Log Ki 31.62 nM
COc1ccc(C[C@@H](C)NC[C@@H]2Oc3ccccc3O[C@@H]2C)cc1S(N)(=O)=O CHEMBL1630942 pKi 31.62 nM
O=c1c2ccccc2c(Cc2ccc(Cl)cc2)nn1C[C@H]1CCCN1CCCCc1ccc(OCCCN2CCCCCC2)cc1 CHEMBL1767164 pKi 31.62 nM
O=c1c2ccccc2c(Cc2ccc(Cl)cc2)nn1C1CCCN(CCc2ccc(OCCCN3CCCCCC3)cc2)CC1 CHEMBL1765111 pKi 31.62 nM
Cc1ccc(Cl)cc1N1CCN(CCc2ccc(CN3C(=O)c4ccccc4C3=O)cc2)CC1 CHEMBL3742103 IC50 31.62 nM
COc1ccccc1OCCNCC1COC(c2ccccc2)(c2ccccc2)OC1 CHEMBL4588223 pKi 31.62 nM
COCC(=O)NCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O CHEMBL5273244 pKi 31.62 nM
CCCNC(=O)CCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O CHEMBL5272464 pKi 31.62 nM
CCC1=C(C(=O)OC)C(c2ccc(F)cc2F)N(C(=O)NCCCN2CCN(c3ccccc3C(N)=O)CC2)C(=O)N1 CHEMBL445577 Ki 32.0 nM
CC(Cc1cc2c(c(C(N)=O)c1)N(CCCO)CC2)NCCOc1cc(Br)ccc1OCC(F)(F)F CHEMBL3808726 IC50 32.7 nM
CC(=O)N1C(=O)N(C)C(C)=C(C(=O)NCCCN2CCC(c3ccc(F)cc3)CC2)[C@H]1c1ccc(F)c(F)c1 CHEMBL90453 Ki 33.0 nM
C[C@H]1[C@@H]2c3ccccc3C[C@]12c1c[nH]cn1 CHEMBL1256378 pKi 33.11 nM
COc1ccccc1N1CCN(CCNc2cc(C)nn(C)c2=O)CC1 CHEMBL80132 Ki 33.13 nM
COc1cccc(OC)c1OCCNC[C@@H]1COc2cccc(Cl)c2O1 CHEMBL2153556 pKi 33.88 nM
COc1ccccc1N1CCN(CCn2c(=O)[nH]c3c(sc4ccc(NC(=O)CCCc5ccccc5)cc43)c2=O)CC1 CHEMBL3298747 pKi 33.88 nM
Cc1ccc(C(C(=O)NCCCN2CCC(c3ccccc3)CC2)c2ccc(C)cc2)cc1 CHEMBL295304 Ki 34.0 nM
COC(=O)C1=C(C)N=C(C)N(CCCCCN2CCN(c3ccccc3C(=O)OC)CC2)C1c1ccc(F)c(F)c1 CHEMBL436407 Ki 34.0 nM
COc1ccc2c(NCCCCCCCNc3ccnc4cc(OC)ccc34)ccnc2c1 CHEMBL3343983 pKi 34.67 nM
N#Cc1ccc(N2CCN(CCc3ccc(CN4C(=O)c5ccccc5C4=O)cc3)CC2)c(F)c1 CHEMBL3740874 IC50 34.76 nM
COCC1=C(C(=O)NCCCN2CCC(c3ccc(F)cc3C#N)CC2)[C@@H](c2ccc(F)c(F)c2)NC(=O)N1 CHEMBL328763 Ki 35.0 nM
COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(sc5ncc(Cl)nc54)c3=O)C[C@@H]21 CHEMBL290387 Ki 35.1 nM
COc1ccc2c(c1OCCNC[C@H]1COc3ccccc3O1)NCC2 CHEMBL3216590 pKi 35.48 nM
O=C1CC2(CCCC2)CC(=O)N1CCN1CCN(c2ccccc2C2CC2)CC1 CHEMBL56804 Ki 35.56 nM
CCOc1ccccc1OCCNC(C)Cc1cc(C(N)=O)c2c(ccn2CCCO)c1 CHEMBL3809248 IC50 35.6 nM
O=C1CC2(CCCC2)CCN1CCN1CCN(c2ccccc2Cl)CC1 CHEMBL299454 Ki 35.94 nM
COCC1=C(C(=O)OC)[C@H](c2ccc(F)c(F)c2)N(C(=O)N[C@H]2CC[C@H](N3CCC(c4ccccc4C#N)CC3)C2)C(=O)N1 CHEMBL433832 Ki 36.0 nM
COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCC(c3ccccc3)CC2)C1c1ccc(F)c(F)c1 CHEMBL145459 Ki 36.0 nM
COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc(F)c(F)c1 CHEMBL144989 Ki 36.0 nM
CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3c(F)cccc3F)CC2)CC1 CHEMBL270589 Ki 36.0 nM
CCC1=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C(c2ccc([N+](=O)[O-])cc2)C(C(N)=O)=C(COCCN)N1 CHEMBL432026 Ki 36.3 nM
COc1ccccc1N1CCN(CCn2c(=O)[nH]c3c(sc4ccc(NC(=O)CCCCc5ccccc5)cc43)c2=O)CC1 CHEMBL3298748 pKi 36.31 nM
CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3cc(F)ccc3F)CC2)CC1 CHEMBL257097 Ki 36.4 nM
CCC1=C(C(=O)OC)C(c2ccc([N+](=O)[O-])cc2)N(C(=O)NCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C(=O)N1 CHEMBL123012 Ki 37.0 nM
Cc1ccc2oc(=O)n(C3CCN(CCCCN4C(=O)c5ccccc5S4(=O)=O)CC3)c2c1 CHEMBL432947 Ki 37.0 nM
CC1=C(C(=O)NCCCN2CCC(c3ccc(F)cc3)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1 CHEMBL43860 Ki 37.0 nM
COc1ccccc1OCCNC[C@@H]1CO[C@H](C(c2ccccc2)c2ccccc2)O1 CHEMBL4526865 pKi 37.15 nM
O=C1CC2(CCCC2)CC(=O)N1CCN1CCC(c2cc(Cl)ccc2Cl)CC1 CHEMBL440118 Ki 37.57 nM
COc1ccccc1N1CCN(CCN(C(=O)C23CCC(CF)(CC2)C3)c2ccccn2)CC1 CHEMBL1910141 Ki 38.0 nM
COc1ccccc1N1CCN(CCn2c(C)nc3c(sc4ccc(NC(=O)c5ccccc5)cc43)c2=O)CC1 CHEMBL3298020 pKi 38.9 nM
COc1ccc(S(=O)(=O)N[C@H]2CC[C@H](N3CCN(c4ccccc4OCC(F)(F)F)CC3)CC2)cc1OC CHEMBL238402 Ki 39.0 nM
CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3ccccc3Cl)CC2)CC1 CHEMBL257098 Ki 39.0 nM
COc1ccccc1N1CCN(CCCNc2c(C)c(=O)n(C)c(=O)n2C)CC1 CHEMBL420060 Log Ki 39.81 nM
COc1ccc(CCNCC2CCc3ccccc3C2)cc1 CHEMBL282214 Log Ki 39.81 nM
Cn1ncnc1-c1ccccc1NCC1=NCCN1 CHEMBL18069 Log EC50 39.81 nM
Cn1ccnc1-c1ccccc1NCC1=NCCN1 CHEMBL18256 Log EC50 39.81 nM
Cc1n[nH]c(=O)n(CCCN2CCN(c3ccccc3OCC(F)(F)F)CC2)c1=O CHEMBL55290 Log Ki 39.81 nM
COc1cc2nc3c(c(N)c2cc1OC)CCC(CNCCOc1c(OC)cccc1OC)C3 CHEMBL143558 Log Ki 39.81 nM
C[C@]12C[C@@]1(c1c[nH]cn1)Cc1ccccc12 CHEMBL1255771 pKi 39.81 nM
CCO[C@H]1c2ccccc2[C@H]2C[C@]21c1c[nH]cn1 CHEMBL1256565 pKi 39.81 nM
O=c1c2ccccc2c(Cc2ccc(Cl)cc2)nn1C[C@@H]1CCCN1CCCCc1ccc(OCCCN2CCCCCC2)cc1 CHEMBL1767168 pKi 39.81 nM
COc1ccccc1OCCNCC1CCC(c2ccccc2)(c2ccccc2)O1 CHEMBL1946779 pKi 39.81 nM
COCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ncccc2c1=O CHEMBL2146811 pKi 39.81 nM
O=c1c2ccncc2c(Cc2ccc(Cl)cc2)nn1C[C@H]1CCCN1CCCCc1ccc(OCCCN2CCCCCC2)cc1 CHEMBL2146813 pKi 39.81 nM
Cc1cccc2c(NCCNc3ccnc4c(C)cccc34)ccnc12 CHEMBL3343979 pKi 39.81 nM
CC1=C(C(=O)NCCCN2CCC(c3ccc(F)cc3)CC2)[C@@H](c2ccc(F)c(F)c2)NC(=O)N1 CHEMBL91405 Ki 40.0 nM
CC[C@H]1c2ccccc2[C@H]2C[C@]21c1c[nH]cn1 CHEMBL1256610 pKi 40.74 nM
COCC1=C(C(=O)NCCCN2CCC(c3ccc(F)cc3)CC2)[C@@H](c2ccc(F)c(F)c2)NC(=O)N1 CHEMBL92951 Ki 41.0 nM
CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)CC2)C1c1ccc(Cl)c([N+](=O)[O-])c1 CHEMBL327931 Log Ki 41.69 nM
COc1ccccc1CCCNCC1COC(c2ccccc2)(c2ccccc2)O1 CHEMBL1088072 pKi 41.69 nM
O=C(CCCN1CCC(O)(c2ccc(Cl)cc2)C1)c1ccc(F)cc1 CHEMBL150161 Ki 41.7 nM
COc1ccc(Br)cc1S(=O)(=O)N[C@H]1CC[C@@H](N2CCN(c3ccccc3OC(C)C)CC2)CC1 CHEMBL233849 Ki 42.0 nM
CC(C)Oc1ccccc1OCCN1CCC(CNS(=O)(=O)c2cccc(Cl)c2F)CC1 CHEMBL3947830 EC50 42.1 nM
COc1ccccc1N1CCN(CC2COC3(CCNCC3)O2)CC1 CHEMBL3342856 pKi 42.66 nM
COc1cc2nc(N3CCC[C@@H](NC(=O)c4ccco4)C3)nc(N)c2cc1OC CHEMBL4171710 pKi 42.66 nM
O=C(CCCN1C2CCC1CC(O)(c1ccc(Cl)cc1)C2)c1ccc(F)cc1 CHEMBL210578 Ki 42.7 nM
COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCN(c3cccc(C(F)(F)F)c3)CC2)C1c1ccc(F)c(F)c1 CHEMBL145525 Ki 43.0 nM
COc1cccc(C2CCC(N3CCN(c4ccccc4OC)CC3)CC2)c1 CHEMBL2112779 Ki 43.3 nM
CCC1(C)CC(=O)N(CCN2CCN(c3cc(Cl)ccc3Cl)CC2)C(=O)C1 CHEMBL57317 Ki 43.35 nM
O=S(=O)(c1ccc2cc[nH]c2c1)N1CCC[C@@H]1CCN1CCC(n2c(O)nc3ccccc32)CC1 CHEMBL115262 Log Ki 43.65 nM
CS(=O)(=O)c1ccccc1CCCNCCOc1cc(F)ccc1Cl CHEMBL4209590 Ki 44.0 nM
CC(C)Oc1ccccc1N1CCN(C2CCC(N3C(=O)c4cccnc4C3=O)CC2)CC1 CHEMBL243228 Ki 44.6 nM
COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C1c1ccc(F)c(F)c1 CHEMBL298713 Ki 45.0 nM
COc1ccccc1OCCNCC1COC(c2ccccc2)(c2ccccc2)O1 CHEMBL286003 Log Ki 45.71 nM
CCOc1ccccc1N1CCN(CC(O)CN2C(=O)NC(=O)C2(c2ccccc2)c2ccccc2)CC1 CHEMBL1258457 pA2 45.71 nM
N#Cc1ccccc1N1CCN(CCN2C(=O)CC3(CCCC3)CC2=O)CC1 CHEMBL299022 Ki 46.18 nM
CC(C)Oc1ccccc1N1CCN(C2CCC(N3C(=O)c4ccc5ccc(F)cc5c4C3=O)CC2)CC1 CHEMBL243866 Ki 46.5 nM
O[C@@H]1[C@H](NC[C@H]2COc3ccccc3O2)CC[C@H]1Oc1ccccc1 CHEMBL135973 Log Ki 46.77 nM
Cc1ccc(-c2ccccc2NCC2=NCCN2)o1 CHEMBL152725 Log EC50 46.77 nM
COc1ccccc1OCCNCC1COC(c2ccccc2)(c2ccccc2)O1 CHEMBL1082862 pKi 46.77 nM
COc1ccccc1N1CCN(C[C@H]2CO[C@@](CN3C(=O)CCCC3=O)(c3ccccc3)O2)CC1 CHEMBL1242818 pKi 46.77 nM
COc1cc2nc(N3CCC[C@@H](NC(=O)[C@H]4COc5ccccc5O4)C3)nc(N)c2cc1OC CHEMBL4159468 pKi 46.77 nM
O=C1CCCN1CCCCN1CCN(c2ccc(F)cc2F)CC1 CHEMBL3400596 EC50 46.9 nM
CC(C)Oc1ccccc1N1CCN(Cc2cccc(C(=O)N3CCCCC3)c2)CC1 CHEMBL10085 Ki 47.0 nM
O=C1CC2(CCCC2)CC(=O)N1CCN1CCN(c2cc(Br)ccc2Br)CC1 CHEMBL56899 Ki 47.54 nM
Cc1ccc2c(NCCNc3ccnc4cc(C)ccc34)ccnc2c1 CHEMBL3343977 pKi 47.86 nM
O=C1CC2(CCN(CCc3cccc4ccccc34)CC2)Oc2ccccc21 CHEMBL101869 Ki 48.0 nM
C[C@H]1OC(=O)N(C(=O)NCCCN2CCC(c3ccc(F)cc3)CC2)[C@H]1c1ccc(F)c(F)c1 CHEMBL2114249 Ki 48.0 nM
COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C1c1ccc(Cl)cc1 CHEMBL146163 Ki 48.0 nM
COc1ccc2c(c1OCCNC[C@@H]1COc3ccccc3O1)CCCC2 CHEMBL217143 Log Ki 48.98 nM
O=C1c2ccccc2CC12CCN(CCc1cccc3ccccc13)CC2 CHEMBL100052 Ki 49.0 nM
COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCN(c3ccccc3[N+](=O)[O-])C[C@@H]2C)C1c1ccc(F)c(F)c1 CHEMBL145547 Ki 49.0 nM
COc1ccc(Cl)cc1N1CCN(CCCCNc2c(C(C)=O)c(C)nn(C)c2=O)CC1 CHEMBL420959 Ki 49.08 nM
COc1ccccc1N1CCN(CCNc2c(C(C)=O)c(C)nn(C)c2=O)CC1 CHEMBL77901 Ki 49.84 nM
COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C1c1cccc(Cl)c1 CHEMBL143066 Ki 50.0 nM
O=C1c2cc(F)ccc2S(=O)(=O)N1CCCCN1CCC(n2c(=O)oc3ccccc32)CC1 CHEMBL83592 Ki 50.0 nM
CO/C(O)=C1\C(C)=NC(C)=C(C(=O)OCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 CHEMBL290860 Ki 50.0 nM
CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3c(Cl)cccc3Cl)CC2)CC1 CHEMBL256597 Ki 50.0 nM
COc1ccc2c(NCCNc3ccnc4cc(OC)ccc34)ccnc2c1 CHEMBL3343978 Ki 50.0 nM
Cn1ccc(-c2ccccc2NCC2=NCCN2)n1 CHEMBL17856 Log EC50 50.12 nM
O=c1[nH]cc(Cl)c(=O)n1CCCN1CCN(c2ccc(F)cc2OCC(F)(F)F)CC1 CHEMBL298838 Log Ki 50.12 nM
CN1CCCC(n2nc(Cc3ccc(Cl)cc3)c3ccccc3c2=O)CC1 CHEMBL639 pKi 50.12 nM
COc1ccc(Cc2nn(C[C@H]3CCCN3CCCCc3ccc(OCCCN4CCCCCC4)cc3)c(=O)c3ccccc23)cc1 CHEMBL1767165 pKi 50.12 nM
O=c1c2ccccc2c(Cc2ccc(Cl)cc2)nn1C[C@H]1CCCN1CCCCCc1ccc(OCCCN2CCCCCC2)cc1 CHEMBL1767167 pKi 50.12 nM
COc1ccccc1N1CCN(CCN2C(=O)CC3(CCCC3)CC2=O)CC1 CHEMBL543741 pKi 50.12 nM
CN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ncccc2c1=O CHEMBL2146809 pKi 50.12 nM
c1cnc2c(N3CCN(CCCCc4ccc(OCCCN5CCCCCC5)cc4)CC3)cccc2c1 CHEMBL3893197 pKi 50.12 nM
COCC1=C(C(=O)OC)[C@H](c2ccc(F)c(F)c2)N(C(=O)N[C@H]2CC[C@@H](N3CCN(c4ccccc4C#N)CC3)C2)C(=O)N1 CHEMBL300821 Ki 51.0 nM
Cc1ccc2c(NCCCCCCCNc3ccnc4cc(C)ccc34)ccnc2c1 CHEMBL3343982 Ki 51.0 nM
COc1ccccc1N1CCN(C[C@@H]2CO[C@@](CN3CCCCC3=O)(c3ccccc3)O2)CC1 CHEMBL1242542 pKi 51.29 nM
COc1cccc(OC)c1OCCNCC1Oc2ccccc2OC1c1ccc(C)cc1 CHEMBL42539 Ki 51.38 nM
C[C@@H]1CCNC(=O)c2cc3ccc(C(=O)Nc4nc5ccccc5n4CCCN(C)C)cc3n21 CHEMBL1933288 IC50 52.0 nM
c1ccc(OCCNC[C@@H]2COCC(c3ccccc3)(c3ccccc3)O2)cc1 CHEMBL493285 pKi 52.48 nM
O=C1CC2(CCCCC2)CC(=O)N1CCN1CCN(c2cc(Cl)ccc2Cl)CC1 CHEMBL293111 Ki 52.89 nM
Cn1cnc(S(=O)(=O)Nc2ccc3c(c2)C(=O)CC2(CCN(CCc4cccc5ccccc45)CC2)O3)c1 CHEMBL101579 Ki 53.0 nM
C1=CC2(CCN(CCc3cccc4ccccc34)CC2)Oc2ccccc21 CHEMBL100878 Ki 53.0 nM
CN1C=C(C(=O)NCCCN2CCC(C#N)(c3ccc(F)cc3)CC2)[C@@H](c2ccc(F)c(F)c2)NC1=O CHEMBL91616 Ki 53.0 nM
COc1cccc(C2CCC(N3CCN(c4ccccn4)CC3)CC2)c1 CHEMBL2112778 Ki 53.1 nM
COc1ccccc1N1CCN(CCCNc2c(C(C)=O)c(C)nn(C)c2=O)CC1 CHEMBL79161 Ki 53.39 nM
CCOc1ccccc1OCCNCC1COC(c2ccccc2)(c2ccccc2)O1 CHEMBL1078953 pKi 53.7 nM
COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(=O)C2(c2ccccc2)c2ccccc2)CC1 CHEMBL1258345 pA2 53.7 nM
CC1=C(C(=O)NCCCN2CCC(c3ccc(F)cc3)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1C CHEMBL287791 Ki 54.0 nM
O=C1CCCC(=O)N1CCN1CCN(c2cc(Cl)ccc2Cl)CC1 CHEMBL294235 Ki 54.08 nM
COc1cc2nc(N3CCC[C@H](N)C3)nc(N)c2cc1OC CHEMBL4163810 pKi 54.95 nM
COc1ccccc1N1CCN(CCN2CCC3(CCCC3)CC2=O)CC1 CHEMBL57859 Ki 54.99 nM
c1ccc2c(c1)CCC1(CCN(CCc3cccc4ccccc34)CC1)O2 CHEMBL101739 Ki 55.0 nM
N#CCc1ccc(N2CCN(CCn3c(=O)[nH]c4c([nH]c5ccccc54)c3=O)CC2)cc1 CHEMBL319345 Log Ki 55.0 nM
COc1ccccc1OCCNCC1COCC(c2ccccc2)(c2ccccc2)O1 CHEMBL2312227 pKi 56.23 nM
c1ccc(OCCNCC2CCOC(c3ccccc3)(c3ccccc3)O2)cc1 CHEMBL4582160 pKi 56.23 nM
O=C1CC2(CCCCC2)CC(=O)N1CCN1CCN(c2ccccc2Cl)CC1 CHEMBL431943 Ki 57.65 nM
O=c1ccc2ccc(OCCCCN3CCN(c4cccc5sccc45)CC3)cc2[nH]1 CHEMBL2105760 Ki 57.94 nM
COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCN(c3ccccc3C(N)=O)CC2)C1c1cc(F)c(F)c(F)c1 CHEMBL357172 Ki 58.0 nM
COc1cccc(OCCNCC2COC(c3ccccc3)(c3ccccc3)O2)c1 CHEMBL1077168 pKi 58.88 nM
CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3ccc(F)c(F)c3)CC2)CC1 CHEMBL256804 Ki 60.0 nM
COc1cc2c3c(c1OC)-c1ccccc1C[C@H]3N(C)CC2 CHEMBL464529 Kb 60.6 nM
COc1cc2c(cc1OC)C(=O)N(CCN1C[C@@H]3CCc4c(OC)cccc4[C@@H]3C1)CC2 CHEMBL291305 Ki 61.2 nM
CS(=O)(=O)c1ccc(Cl)cc1NCC1=NCCN1 CHEMBL70634 Log EC50 61.66 nM
CC(C)Sc1ccccc1NCC1=NCCN1 CHEMBL553276 Log EC50 61.66 nM
CCOc1ccccc1N1CCN(CCn2cnc3c4ccccc4nc-3c2O)CC1 CHEMBL433014 Log Ki 61.66 nM
COc1ccc(-c2ccccc2)cc1OCCNC[C@@H]1COc2ccccc2O1 CHEMBL214552 Log Ki 61.66 nM
O=C1CC2(CCCC2)CC(=O)N1CCN1CCN(c2ccccc2F)CC1 CHEMBL299691 Ki 62.62 nM
c1ccc(C2CC2)c(OCC2=NCCN2)c1 CHEMBL13852 Log EC50 63.1 nM
CC(C)(C)OC(=O)c1ccccc1NCC1=NCCN1 CHEMBL98243 Log EC50 63.1 nM
CCn1ncnc1-c1ccccc1NCC1=NCCN1 CHEMBL273316 Log EC50 63.1 nM
c1ccc(OCCNCC2COC(c3ccccc3)(c3ccccc3)O2)cc1 CHEMBL37883 Log Ki 63.1 nM
COc1cc2c(cc1OC)NCN(CCN1C[C@@H]3CCc4c(OC)cccc4[C@@H]3C1)C2 CHEMBL302192 Ki 63.1 nM
Cc1c[nH]c(=O)n(CC2(CN3CCN(c4ccccc4OCC(F)(F)F)CC3)CC2)c1=O CHEMBL55629 Log Ki 63.1 nM
c1ccc(OCCNCC2COC(c3ccccc3)(c3ccccc3)O2)cc1 CHEMBL1083181 pKi 63.1 nM
CO[C@H]1c2ccccc2[C@H]2C[C@]21c1c[nH]cn1 CHEMBL1256503 pKi 63.1 nM
COc1ccccc1N1CCN(CC2COC3(CCN(C(=O)c4ccc(C(F)(F)F)cc4)CC3)O2)CC1 CHEMBL3342860 pKi 63.1 nM
COc1cc2nc(N3CCC[C@H](NC(=O)[C@H]4COc5ccccc5O4)C3)nc(N)c2cc1OC CHEMBL4170675 pKi 63.1 nM
CC(C)C(=O)NCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O CHEMBL5275284 pKi 63.1 nM
COCCC(=O)NCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O CHEMBL5286701 pKi 63.1 nM
CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 CHEMBL284470 Log Ki 64.57 nM
COc1ccccc1N1CCN(CCN2C(=O)CC3(CCCC3)CC2=O)CC1 CHEMBL13647 Log Ki 64.57 nM
COc1ccccc1OCCNCC[C@@H]1CO[C@H](C(c2ccccc2)c2ccccc2)O1 CHEMBL4579802 pKi 64.57 nM
CCCCC1CCN(CCCC(=O)c2ccccc2C)CC1 CHEMBL1242950 Ki 65.0 nM
CN1CCN2c3c(cccc31)[C@@H]1CN(CCCc3noc4cc(F)ccc34)CC[C@@H]12 CHEMBL3233412 Ki 66.0 nM
COc1ccccc1N1CCN(CCN(C(=O)C2CCCCC2)c2ccccn2)CC1 CHEMBL31354 pKi 66.07 nM
COc1ccccc1N1CCN(CCN(C(=O)C2CCCCC2)c2ccccn2)CC1 CHEMBL514874 pKi 66.07 nM
COC(=O)C1=C(C)N=C(C)N(CCCCCN2CCN(c3ccccc3OC)CC2)C1c1ccc(F)c(F)c1 CHEMBL145587 Ki 67.0 nM
COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C1c1cccc(F)c1 CHEMBL356978 Ki 67.0 nM
COc1ccc(C[C@@H](C)NC[C@H]2Oc3ccccc3O[C@H]2C)cc1S(N)(=O)=O CHEMBL1630941 pKi 67.61 nM
COc1ccccc1N1CCN(CC2COC3(CCN(C(=O)c4ccccc4)CC3)O2)CC1 CHEMBL3342859 pKi 67.61 nM
COc1ccccc1OCCNCC1OCCOC1(c1ccccc1)c1ccccc1 CHEMBL4559278 pKi 67.61 nM
CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)NCc3cccc(F)c3)CC2)CC1 CHEMBL256041 Ki 69.0 nM
Cc1nc(-c2ccccc2NCC2=NCCN2)cs1 CHEMBL434074 Log EC50 69.18 nM
COc1ccccc1N1CCN(CC2COC3(CCN(S(=O)(=O)c4ccc(Cl)cc4)CC3)O2)CC1 CHEMBL3342868 pKi 69.18 nM
COc1ccccc1N1CCN(CC2COC3(CCN(S(=O)(=O)c4cccc([N+](=O)[O-])c4)CC3)O2)CC1 CHEMBL3342871 pKi 69.18 nM
COCC1=C(C(=O)OC)[C@H](c2ccc(F)c(F)c2)N(C(=O)N[C@H]2CC[C@@H](N3CCC(c4ccccc4C#N)CC3)C2)C(=O)N1 CHEMBL292365 Ki 70.0 nM
COc1ccccc1N1CCN(C[C@@H]2CO[C@](CN3CCCC3=O)(c3ccccc3)O2)CC1 CHEMBL1242445 pKi 70.79 nM
COc1ccc(F)cc1OCCNC(C)Cc1cc(C(N)=O)c2c(ccn2CCCO)c1 CHEMBL3810110 IC50 70.9 nM
CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3cccc(Cl)c3)CC2)CC1 CHEMBL257077 Ki 71.0 nM
CN1C=C(C(=O)NCCCN2CCC(C#N)(c3ccc(F)cc3C#N)CC2)[C@@H](c2ccc(F)c(F)c2)N(C)C1=O CHEMBL93843 Ki 72.0 nM
COc1cccc(OC)c1OCCNC[C@@H]1COc2ccccc2O1 CHEMBL214986 Log Ki 72.44 nM
COc1ccccc1N1CCN(C[C@H]2CO[C@@](CN3CCCCCC3=O)(c3ccccc3)O2)CC1 CHEMBL1242632 pKi 72.44 nM
COc1cccc(OC)c1OCCNC[C@@H]1COc2ccccc2O1 CHEMBL36622 pKi 72.44 nM
COc1cccc(OC)c1OCCNC[C@@H]1COc2ccccc2O1 CHEMBL3740374 pKi 72.44 nM
Cc1ccccc1N1CCN(CCN2C(=O)CC3(CCCC3)CC2=O)CC1 CHEMBL291908 Ki 73.53 nM
C[C@H]1OC(=O)N(C(=O)NCCCN2CCC(c3ccc(F)cc3)CC2)[C@@H]1c1ccc(F)c(F)c1 CHEMBL2111563 Ki 74.0 nM
COc1ccccc1OCCNC[C@@H]1COC(c2ccccc2)(c2ccccc2)CO1 CHEMBL493283 pKi 74.13 nM
COc1ccccc1OCCNC[C@H]1CCC(c2ccccc2)(c2ccccc2)[C@@H]1O CHEMBL1946786 pKi 74.13 nM
O=C1CCc2ccccc2N1CCCN1CCN(c2ccccc2)CC1 CHEMBL4085780 pKi 74.13 nM
O=C1c2ccc([N+](=O)[O-])cc2S(=O)(=O)N1CCCCN1CCC(n2c(=O)oc3ccccc32)CC1 CHEMBL82877 Ki 75.0 nM
CNC[C@H](O)c1ccc(O)c(O)c1 CHEMBL679 EC50 75.0 nM
COc1cccc(OC)c1OCCNCC1COC(c2ccccc2)(c2ccccc2)O1 CHEMBL1087942 pKi 75.86 nM
C[C@@H]1OC(=O)N(C(=O)NCCCN2CCC(c3ccc(F)cc3)CC2)[C@@H]1c1ccc(F)c(F)c1 CHEMBL2112365 Ki 76.0 nM
O=S(=O)(N[C@H]1CC[C@@H](N2CCC(c3ccccc3OCC(F)(F)F)CC2)CC1)c1ccc(OC(F)F)cc1 CHEMBL387832 Ki 76.0 nM
CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3ccc(F)cc3F)CC2)CC1 CHEMBL403280 Ki 76.0 nM
COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C1c1ccc(C)cc1 CHEMBL359173 Ki 77.0 nM
CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 CHEMBL91956 Log Ki 77.62 nM
c1cnc(-c2ccccc2NCC2=NCCN2)nc1 CHEMBL156661 Log EC50 77.62 nM
CC(C)Oc1ccccc1N1CCN(CCc2ccccc2)CC1 CHEMBL3967641 pKi 77.62 nM
COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C1c1ccc(F)cc1 CHEMBL145610 Ki 78.0 nM
CN1C[C@H](c2c[nH]c3c(Br)c(Br)cc(O)c23)NC[C@H]1c1c[nH]c2cc(Br)ccc12 CHEMBL302882 Ki 78.0 nM
COc1ccc(Cl)cc1S(=O)(=O)N[C@H]1CC[C@@H](N2CCN(c3ccccc3OC(C)C)CC2)CC1 CHEMBL233816 Ki 78.0 nM
CCCNC(=O)c1ccccc1NCC1=NCCN1 CHEMBL318544 Log EC50 79.43 nM
CC(C)COC(=O)c1ccccc1NCC1=NCCN1 CHEMBL95398 Log EC50 79.43 nM
CN(C)C(=O)c1ccccc1NCC1=NCCN1 CHEMBL100198 Log EC50 79.43 nM
O=C(c1ccccc1NCC1=NCCN1)N1CCCCC1 CHEMBL95333 Log EC50 79.43 nM
Cc1c[nH]c(=O)n(CCCN2CCN(c3ccc(F)cc3OCC(F)(F)F)CC2)c1=O CHEMBL24777 Log Ki 79.43 nM
c1cncc(-c2ccccc2OCC2=NCCN2)c1 CHEMBL356605 Log EC50 79.43 nM
c1ccc(-c2cc[nH]n2)c(OCC2=NCCN2)c1 CHEMBL344551 Log EC50 79.43 nM
c1ccc(-c2cn[nH]c2)c(NCC2=NCCN2)c1 CHEMBL275844 Log EC50 79.43 nM
CCc1c[nH]c(=O)n(CCCN2CCN(c3ccc(F)cc3OCC(F)(F)F)CC2)c1=O CHEMBL53675 Log Ki 79.43 nM
COc1cc2nc3c(c(N)c2cc1OC)CC(CNC(=O)c1ccco1)C3 CHEMBL423018 Log Ki 79.43 nM
Clc1cccc(Cl)c1OCCNCCOc1ccccc1OCc1ccccc1 CHEMBL1255002 pKi 79.43 nM
CN1CCC(Cn2nc(Cc3ccc(Cl)cc3)c3ccccc3c2=O)C1 CHEMBL1767155 pKi 79.43 nM
CN1CCC[C@@H]1Cn1nc(Cc2ccc(F)cc2)c2ccccc2c1=O CHEMBL1767140 pKi 79.43 nM
O=c1c2ccccc2c(Cc2ccc(Cl)cc2)nn1C1CCCN(CCCc2ccc(OCCCN3CCCCCC3)cc2)CC1 CHEMBL1767160 pKi 79.43 nM
COc1cccc(OC)c1OCCNC[C@@H]1COc2cccc(OC)c2O1 CHEMBL2153554 pKi 79.43 nM
c1ccc(OCCNC[C@@H]2COC(c3ccccc3)(c3ccccc3)O2)cc1 CHEMBL3739897 pKi 79.43 nM
O=C(O)/C=C/c1ccc2cccc(N3CCN(CCc4ccc(OCCCN5CCCCCC5)cc4)CC3)c2n1 CHEMBL3952802 pKi 79.43 nM
CCCC(=O)NCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O CHEMBL5269671 pKi 79.43 nM
O=C(NCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O)C1CCCC1 CHEMBL5276489 pKi 79.43 nM
O=C1CC2(CCC2)CC(=O)N1CCN1CCN(c2cc(Cl)ccc2Cl)CC1 CHEMBL55882 Ki 79.62 nM
COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCC(c3ccc(C)cc3)(c3ccccc3C)CC2)C1c1ccc(F)c(F)c1 CHEMBL145894 Ki 80.0 nM
COc1ccc(Cl)cc1NC(=O)NC1CCC(N2CCN(c3ccccc3OC(C)C)CC2)CC1 CHEMBL271913 Ki 81.0 nM
COc1ccccc1N1CCN(CC2COC3(CCN(C(=O)Nc4ccccc4)CC3)O2)CC1 CHEMBL3342874 pKi 81.28 nM
COc1ccc(Cl)cc1S(=O)(=O)N[C@H]1CC[C@@H](N2CCC(c3ccccc3OC3CC3)CC2)CC1 CHEMBL388897 Ki 82.0 nM
CC(C)Oc1ccccc1N1CCN([C@H]2CC[C@@H](NS(=O)(=O)Cc3ccccc3)CC2)CC1 CHEMBL234649 Ki 82.0 nM
Cc1nc2c([nH]c3ccccc32)c(=O)n1CCN1CCN(c2ccc(Cl)c(Cl)c2)CC1 CHEMBL220717 Log Ki 83.18 nM
O=C1CC2(CCCC2)C(=O)N1CCN1CCN(c2cc(Cl)ccc2Cl)CC1 CHEMBL56620 Ki 83.61 nM
COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCC(c3ccc(Cl)cc3)(c3ccc(Cl)cc3)CC2)C1c1ccc(F)c(F)c1 CHEMBL356571 Ki 84.0 nM
Clc1ccccc1N1CCN(CCN2CCC3(CCCC3)CC2)CC1 CHEMBL293734 Ki 84.08 nM
COC(=O)C1=C(C)NC(C)=C(C(=O)OCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 CHEMBL3392246 Ki 85.0 nM
CC1=C(C(=O)NCCCN2CCC(c3ccc(F)cc3)CC2)[C@H](c2ccc(F)c(F)c2)N(C)C(=O)N1C CHEMBL93693 Ki 85.0 nM
COc1ccc([N+](=O)[O-])cc1S(=O)(=O)N[C@H]1CC[C@@H](N2CCN(c3ccccc3OC(C)C)CC2)CC1 CHEMBL429623 Ki 85.0 nM
CSc1c(F)cccc1NCC1=NCCN1 CHEMBL70692 Log EC50 85.11 nM
COc1ccc2ccccc2c1OCCNC[C@@H]1COc2ccccc2O1 CHEMBL439346 Log Ki 85.11 nM
COc1ccccc1N1CCN(C[C@H]2CO[C@@](CN3C(=O)CCC3=O)(c3ccccc3)O2)CC1 CHEMBL1242724 pKi 85.11 nM
COc1ccccc1N1CCN(CC2COC3(CCN(S(=O)(=O)c4ccccc4)CC3)O2)CC1 CHEMBL3342866 pKi 85.11 nM
COc1ccccc1N1CCN(CC2COC3(CCN(S(=O)(=O)c4cccs4)CC3)O2)CC1 CHEMBL3342872 pKi 85.11 nM
COc1ccc(S(=O)(=O)N[C@H]2CC[C@@H](N3CCN(c4ccccc4OCC(F)(F)F)CC3)CC2)cc1OC CHEMBL438673 Ki 86.0 nM
CNCc1ccccc1-c1csc([C@H](C)Nc2nc(C)nc3cc(OC)c(OC)cc23)c1 CHEMBL4520788 pKi 86.1 nM
O=C1CCC(=O)N1CCN1CCN(c2cc(Cl)ccc2Cl)CC1 CHEMBL294646 Ki 86.38 nM
O=C1CC2(CCCC2)CC(=O)N1CCN1CCN(c2ccccc2Cl)CC1 CHEMBL57593 Ki 86.96 nM
CC(C)=CCOc1ccc(Cl)c2c1CCN(C)CC2 CHEMBL114166 Ki 87.0 nM
CC1=C(C(=O)NCCCN2CCC(c3ccc(F)cc3C#N)CC2)[C@@H](c2ccc(F)c(F)c2)NC(=O)N1 CHEMBL92328 Ki 87.0 nM
COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C1c1ccc(F)cc1F CHEMBL141444 Ki 88.0 nM
O=S(=O)(c1ccc2cc[nH]c2c1)N1CCC[C@@H]1CCN1CCC(c2cc3ccccc3[nH]2)CC1 CHEMBL331803 Log Ki 89.13 nM
COCC1=C(C(=O)OC)[C@H](c2ccc(F)c(F)c2)N(C(=O)N[C@@H]2CC[C@@H](N3CCC(c4ccccc4C#N)CC3)C2)C(=O)N1 CHEMBL262002 Ki 91.0 nM
O=S(=O)(N[C@H]1CC[C@H](N2CCC(c3ccccc3OCC(F)(F)F)CC2)CC1)c1ccc2c(c1)OCCO2 CHEMBL228390 Ki 91.0 nM
COc1ccc(Cl)cc1N1CCN(CCn2c(=O)[nH]c3c(sc4ccccc43)c2=O)CC1 CHEMBL223289 Log Ki 91.2 nM
COc1ccccc1N1CCN(CCc2ccccc2)CC1 CHEMBL27021 pKi 91.2 nM
COc1ccccc1OCCNCC(CO)OC(c1ccccc1)c1ccccc1 CHEMBL4439658 pKi 91.2 nM
O=S(=O)(N[C@H]1CC[C@@H](N2CCC(c3ccccc3OCC(F)(F)F)CC2)CC1)c1ccc2c(c1)OCCO2 CHEMBL439197 Ki 92.0 nM
COC(=O)C1=C(C)N=C(C)N(CCCCCN2CCC(c3ccccc3)CC2)C1c1ccc(F)c(F)c1 CHEMBL359421 Ki 93.0 nM
O[C@@H]1[C@H](NC[C@@H]2COc3ccccc3O2)CC[C@H]1Oc1ccccc1 CHEMBL134428 Log Ki 93.33 nM
O=C(c1ccc(Cl)cc1)C1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc3cc[nH]c3c2)CC1 CHEMBL116292 Log Ki 93.33 nM
COc1ccccc1N1CCN(CCCSc2nnc(-c3ccccc3)n2C)CC1 CHEMBL4083252 Ki 94.0 nM
COc1cc2c(cc1OC)C(=O)N(CCN1C[C@@H]3CCc4c(OC)cccc4[C@@H]3C1)CN2 CHEMBL303988 Ki 95.2 nM
Cc1cc(-c2ccccc2NCC2=NCCN2)on1 CHEMBL347268 Log EC50 95.5 nM
c1ccc(OCCNCCC2COC(c3ccccc3)(c3ccccc3)O2)cc1 CHEMBL4520390 pKi 95.5 nM
COc1ccccc1N1CCN(CCCCCN2C(=O)CC(c3ccccc3)CC2=O)CC1 CHEMBL1796036 pKi 97.72 nM
Cc1ccc(C2(c3ccc(C)cc3)CC(=O)N(CCCN3CCC(C#N)(c4ccccc4Cl)CC3)C2=O)cc1 CHEMBL62045 Ki 98.0 nM
CCC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(COCCN=[N+]=[N-])N1 CHEMBL98063 Ki 98.3 nM