Cc1cccc([C@H](C)c2c[nH]cn2)c1C CHEMBL778 Ki 0.015 nM
COc1cc2nc(N3CCN(C(=O)c4ccco4)CC3)nc(N)c2cc1OC CHEMBL2 Kb 0.025 nM
COc1cccc(OC)c1OCCNCCOc1ccccc1OCc1ccc(Cl)cc1 CHEMBL200446 Log Ki 0.03162 nM
COc1cc2nc(N3CCN(C(=O)OCc4ccccc4)[C@@H]4CCCC[C@@H]43)nc(N)c2cc1OC CHEMBL4128084 pKi 0.03981 nM
COc1cc2c(cc1OC)CN(c1cc(N)c3cc(OC)c(OC)cc3n1)CC2 CHEMBL324090 Ki 0.04 nM
COc1cccc(OC)c1OCCNCCOc1ccccc1OCc1ccc([N+](=O)[O-])cc1 CHEMBL196817 Log Ki 0.05012 nM
COc1cccc(OC)c1OCCNCCOc1ccccc1OCc1cccc(Cl)c1 CHEMBL198860 Log Ki 0.05012 nM
COc1ccccc1N1CCN(CCn2c(=O)[nH]c3c(sc4ccc(NC(=O)CCCC(=O)N(C)Cc5ccccc5)cc43)c2=O)CC1 CHEMBL3297829 pKi 0.05623 nM
CCOc1ccccc1OCCN[C@H](C)Cc1ccc(OC)c(S(N)(=O)=O)c1 CHEMBL836 Ki 0.058 nM
COc1cc2nc(N3CCN(C(=O)c4ccco4)[C@@H]4CCCC[C@@H]43)nc(N)c2cc1OC CHEMBL342062 pKi 0.06026 nM
COc1cccc(OC)c1OCCNCCOc1ccccc1OCc1cccc([N+](=O)[O-])c1 CHEMBL197442 Log Ki 0.0631 nM
COc1cccc(OC)c1OCCNCCOc1ccccc1OCc1ccc(C)cc1 CHEMBL200366 Log Ki 0.0631 nM
CCCN(CCC)c1nc(N2CCN(C(=O)c3ccco3)[C@@H]3CCCC[C@@H]32)nc2cc(OC)c(OC)cc12 CHEMBL4126860 pKi 0.0631 nM
COc1cccc(OC)c1OCCNCCOc1ccccc1OCc1ccccc1 CHEMBL43116 Log Ki 0.06761 nM
Brc1csc(Cc2c[nH]cn2)c1Br CHEMBL1203855 Ki 0.07 nM
CCc1sccc1Cc1c[nH]cn1 CHEMBL1744288 Ki 0.07 nM
CC(c1c[nH]cn1)c1cscc1Br CHEMBL1788145 Ki 0.08 nM
Clc1cc(Cc2c[nH]cn2)c(Cl)s1 CHEMBL1744273 Ki 0.088 nM
COc1cccc(OC)c1OCCNC[C@@H]1C[C@H](c2ccccc2)c2ccccc2O1 CHEMBL42472 Log Ki 0.08913 nM
c1ccc2c(Cc3c[nH]cn3)csc2c1 CHEMBL1744270 Ki 0.09 nM
CC(C)Oc1ccccc1N1CCN(C2CCC(N3C(=O)c4cccc(F)c4C3=O)CC2)CC1 CHEMBL243694 Ki 0.09 nM
Cc1csc(C)c1Cc1c[nH]cn1 CHEMBL1744272 Ki 0.1 nM
COc1ccc(COc2ccccc2OCCNCCOc2c(OC)cccc2OC)cc1 CHEMBL200580 Log Ki 0.1 nM
CC(Cc1cc(C(N)=O)c2c(ccn2CCCO)c1)NCCOc1ccccc1OCc1ccccc1 CHEMBL3809093 IC50 0.1 nM
COc1cccc(OC)c1OCCNCCOc1ccccc1OCc1ccccc1C CHEMBL382972 Log Ki 0.1259 nM
O=C1CC2(CCCC2)CC(=O)N1CCN1CCN(c2cc(Cl)ccc2Cl)CC1 CHEMBL56438 pKi 0.1288 nM
COc1ccccc1N1CCN(CCNc2c(C(C)=O)c(-c3ccccc3)nn(C)c2=O)CC1 CHEMBL80641 Ki 0.13 nM
CC(C)Oc1ccccc1N1CCN([C@H]2CC[C@@H](NS(=O)(=O)c3cnc(Cl)c(Br)c3)CC2)CC1 CHEMBL232609 Ki 0.14 nM
COc1ccccc1N1CCN(CCn2c(=O)[nH]c3c(sc4ccc(NC(=O)CCCC(=O)NCc5ccccc5)cc43)c2=O)CC1 CHEMBL3298750 pKi 0.1413 nM
COc1cc2nc(N3CCN(C(C)=O)[C@@H]4CCCC[C@@H]43)nc(N)c2cc1OC CHEMBL4129461 pKi 0.1514 nM
COc1ccc(Cl)cc1N1CCN(CCn2c(C)nc3c([nH]c4ccccc43)c2=O)CC1 CHEMBL220515 Log Ki 0.166 nM
COc1cc2nc(N3CCN(C(=O)C4COc5ccccc5O4)[C@H]4CCCC[C@H]43)nc(N)c2cc1OC CHEMBL564481 pKi 0.1698 nM
COc1cc2nc(N3CCN(C(=O)c4ccco4)[C@H]4CCCC[C@H]43)nc(N)c2cc1OC CHEMBL423294 pKi 0.1698 nM
Cc1csc(Cc2c[nH]cn2)c1C CHEMBL1203846 Ki 0.17 nM
COc1cccc(OC)c1SCCNCCOc1ccccc1OCc1ccccc1 CHEMBL1254582 pKi 0.1778 nM
CC(c1c[nH]cn1)c1sccc1Br CHEMBL355784 Ki 0.18 nM
COc1cccc(OC)c1OCCNCC1CC(c2ccccc2)c2ccccc2C1=O CHEMBL44403 Log Ki 0.182 nM
COc1cc2nc(N(C)CCCCCCN(C)C(=O)c3ccco3)nc(N)c2cc1OC CHEMBL27013 Log Ki 0.195 nM
COc1cccc(OC)c1OCCNCCOc1ccccc1OCc1cccc(C)c1 CHEMBL199080 Log Ki 0.1995 nM
CC(C)Oc1ccccc1N1CCN(C2CCC(N3C(=O)c4ccc5ccccc5c4C3=O)CC2)CC1 CHEMBL243864 Ki 0.2 nM
Brc1cscc1Cc1c[nH]cn1 CHEMBL1744289 Ki 0.23 nM
COc1cc2nc(N(C)CCCCCCN(C)C(=O)c3cccc(CN(C)C)c3)nc(N)c2cc1OC CHEMBL341665 Log Ki 0.2455 nM
COc1ccc(C[C@@H](C)NCCOc2ccccc2OC(C)C)cc1S(N)(=O)=O CHEMBL1630938 pKi 0.2455 nM
CCC(=O)c1c(-c2ccccc2)nn(C)c(=O)c1NCCN1CCN(c2ccccc2OC)CC1 CHEMBL78874 Ki 0.25 nM
CC(=O)c1c(-c2ccccc2)nn(C)c(=O)c1NCCN1CCN(c2ccccc2Cl)CC1 CHEMBL310599 Ki 0.25 nM
COc1cccc(OC)c1OCCNCC1COc2ccccc2O1 CHEMBL25554 Log Ki 0.2512 nM
COc1cccc(OC)c1OCCNCCOc1ccccc1OCc1ccccc1Cl CHEMBL200839 Log Ki 0.2512 nM
COc1ccccc1N1CCN(CCn2c(=O)[nH]c3scc(-c4ccccc4)c3c2=O)CC1 CHEMBL268758 Ki 0.252 nM
CCc1cscc1C(C)c1c[nH]cn1 CHEMBL1744263 Ki 0.28 nM
CCc1cscc1Cc1c[nH]cn1 CHEMBL1744278 Ki 0.29 nM
COc1ccccc1N1CCN(CCCCN2C(=O)c3ccccc3C2=O)CC1 CHEMBL8618 Ki 0.3 nM
CC(C)Oc1ccccc1N1CCN(C2CCC(N3C(=O)c4cc(Cl)c(Cl)cc4C3=O)CC2)CC1 CHEMBL243692 Ki 0.3 nM
CC(Cc1cc2c(c(C(N)=O)c1)N(CCCO)CC2)NCCOc1cc(Br)ccc1OCC(F)(F)F CHEMBL3808726 IC50 0.3 nM
CNc1ccc2c(c1)[C@@H](NCCOc1cc(F)ccc1F)CCS2(=O)=O CHEMBL4207824 Ki 0.3 nM
COc1ccccc1N1CCN(CCn2c(=O)[nH]c3sccc3c2=O)CC1 CHEMBL13735 Ki 0.308 nM
COc1ccccc1N1CCN(CCn2c(=O)[nH]c3scc(-c4cccc(C)c4)c3c2=O)CC1 CHEMBL13856 Ki 0.312 nM
COc1cccc(COc2ccccc2OCCNCCOc2c(OC)cccc2OC)c1 CHEMBL427552 Log Ki 0.3162 nM
COc1ccc(C[C@@H](C)NCCOc2ccccc2OCc2ccccc2)cc1S(N)(=O)=O CHEMBL1630939 pKi 0.3236 nM
COc1cc2nc(N3CCN(C(=O)C4COc5ccccc5O4)CC3)nc(N)c2cc1OC CHEMBL707 pKi 0.3236 nM
COc1cc2nc(N3CCC[C@H](NC(=O)c4ccco4)C3)nc(N)c2cc1OC CHEMBL4161165 pKi 0.3311 nM
Brc1ccsc1Cc1c[nH]cn1 CHEMBL1203850 Ki 0.35 nM
COc1ccc(S(=O)(=O)N[C@H]2CC[C@@H](N3CCN(c4ccccc4OCC(F)(F)F)CC3)CC2)cc1OC CHEMBL438673 Ki 0.35 nM
COc1ccccc1N1CCN(CCn2c(=O)[nH]c3c([nH]c4ccccc43)c2=O)CC1 CHEMBL301707 Log Ki 0.3631 nM
COc1cccc(OC)c1OCCNC[C@H]1COc2cccc(OC)c2O1 CHEMBL2153553 pKi 0.3715 nM
COc1ccccc1N1CCN(CCn2c(=O)[nH]c3c(sc4ccc(NC(=O)CCC(=O)NCc5ccccc5)cc43)c2=O)CC1 CHEMBL3298749 pKi 0.3715 nM
COc1cc2nc(N3CCN(C(=O)CC4CCSS4)CC3)nc(N)c2cc1OC CHEMBL178673 Log Ki 0.389 nM
CCOc1cccc(OCC)c1OCCNCCOc1ccccc1OCc1ccccc1 CHEMBL1254742 pKi 0.389 nM
COc1cc2nc(N3CCN(C(=O)COc4c(OC)cccc4C(C)C)[C@H]4CCCC[C@H]43)nc(N)c2cc1OC CHEMBL4129291 pKi 0.389 nM
Cc1cscc1C(C)c1c[nH]cn1 CHEMBL1744271 Ki 0.39 nM
COc1ccccc1N1CCN(CCn2c(C)nc3c(sc4ccccc43)c2=O)CC1 CHEMBL220221 Log Ki 0.3981 nM
CCc1cc(Cc2c[nH]cn2)c(CC)s1 CHEMBL1744276 Ki 0.4 nM
CCN(CC)c1ccc2cc(-n3cc(C(=O)N4CCN(c5nc(N)c6cc(OC)c(OC)cc6n5)CC4)nn3)c(=O)oc2c1 CHEMBL3582270 Ki 0.4 nM
COc1ccccc1OCCNC(C)Cc1cc(C(N)=O)c2c(ccn2CCCO)c1 CHEMBL3809319 IC50 0.4 nM
COc1ccc(F)cc1OCCNC(C)Cc1cc(C(N)=O)c2c(ccn2CCCO)c1 CHEMBL3810110 IC50 0.4 nM
CCc1ccccc1OCCNC(C)Cc1cc(C(N)=O)c2c(ccn2CCCO)c1 CHEMBL3808999 IC50 0.4 nM
COc1ccc(F)cc1OCCNC(C)Cc1cc2c(c(C(N)=O)c1)N(CCCO)CC2 CHEMBL3808896 IC50 0.4 nM
COc1ccccc1N1CCN(CCn2c(C)nc3c4ccccc4nc-3c2O)CC1 CHEMBL99142 Log Ki 0.4074 nM
COc1ccc(Cl)cc1N1CCN(CCNc2c(C(C)=O)c(-c3ccccc3)nn(C)c2=O)CC1 CHEMBL80458 Ki 0.41 nM
COc1ccccc1N1CCN(CCNc2c(C(=O)C(C)C)c(-c3ccccc3)nn(C)c2=O)CC1 CHEMBL80730 Ki 0.43 nM
CC(c1c[nH]cn1)c1scc(Br)c1Br CHEMBL1744280 Ki 0.43 nM
COc1cccc(OC)c1OCCNCC1CC(c2ccccc2)c2ccccc2S1 CHEMBL43905 Log Ki 0.4365 nM
Cc1sccc1Cc1c[nH]cn1 CHEMBL1744294 Ki 0.44 nM
Cc1ccsc1Cc1c[nH]cn1 CHEMBL1203848 Ki 0.45 nM
COc1ccccc1N1CCN(CCn2c(=O)[nH]c3sc(C)c(-c4ccccc4)c3c2=O)CC1 CHEMBL13754 Ki 0.466 nM
Cc1cscc1Cc1c[nH]cn1 CHEMBL1744291 Ki 0.47 nM
COc1cc2nc(N3CCN(C(=O)C4CCSS4)CC3)nc(N)c2cc1OC CHEMBL175934 Log Ki 0.4898 nM
COc1cc2nc(N3CCN(C(=O)C4COc5ccccc5O4)[C@@H]4CCCC[C@@H]43)nc(N)c2cc1OC CHEMBL558890 pKi 0.4898 nM
COc1cccc(OC)c1OCCNC[C@H]1COc2cccc(F)c2O1 CHEMBL2153557 pKi 0.4898 nM
CC(=O)c1c(-c2ccccc2)nn(C)c(=O)c1NCCN1CCN(c2ccccc2F)CC1 CHEMBL420205 Ki 0.49 nM
CC(C)Oc1ccccc1N1CCN(C2CCC(N3C(=O)c4ccc5ccc(F)cc5c4C3=O)CC2)CC1 CHEMBL243866 Ki 0.5 nM
COC(=O)c1ccccc1NCC1=NCCN1 CHEMBL414185 Log EC50 0.5012 nM
COc1ccccc1N1CCN(CCCCN2C(=O)CC(C)(c3ccccc3)CC2=O)CC1 CHEMBL1796046 pKi 0.5012 nM
COc1cccc(OC)c1OCCNC[C@H]1COc2ccccc2O1 CHEMBL215421 Log Ki 0.5129 nM
COc1cccc([N+](=O)[O-])c1OCCNCCOc1ccccc1OCc1ccccc1 CHEMBL1254743 pKi 0.5129 nM
COc1cccc(OC)c1OCCNC[C@H]1COc2ccccc2O1 CHEMBL1182155 pKi 0.5129 nM
COc1cccc(OC)c1OCCNC[C@H]1COc2ccccc2O1 CHEMBL3741808 pKi 0.5129 nM
COc1ccccc1N1CCN(CCn2c(=O)[nH]c3c(sc4ccc(NC(=O)c5ccccc5)cc43)c2=O)CC1 CHEMBL3298745 pKi 0.5754 nM
CCOc1ccccc1N1CCN(CCc2ccc(OC)c(OC)c2)CC1 CHEMBL3902626 pKi 0.6026 nM
CC(C)Oc1ccccc1N1CCN([C@H]2CC[C@@H](NS(=O)(=O)c3ccc(Cl)cc3Cl)CC2)CC1 CHEMBL391035 Ki 0.64 nM
CC(c1cccc(Cl)c1)n1cc(Cl)cc(C(N)=O)c1=N CHEMBL3798124 Ki 0.66 nM
COc1ccc(S(=O)(=O)N[C@H]2CC[C@@H](N3CCN(c4ccccc4OC(C)C)CC3)CC2)cc1OC CHEMBL391530 Ki 0.68 nM
Cc1cc(Cc2c[nH]cn2)c(C)s1 CHEMBL1744277 Ki 0.69 nM
COc1cccc(OC)c1OCCNC[C@H]1COc2cccc(Cl)c2O1 CHEMBL2153555 pKi 0.7079 nM
COc1cc2nc(N(C)CCSSCCN(C)C(=O)c3ccco3)nc(N)c2cc1OC CHEMBL29591 Log Ki 0.7244 nM
COc1cccc(Cl)c1OCCNCCOc1ccccc1OCc1ccccc1 CHEMBL1254828 pKi 0.7413 nM
Cc1csc(C(C)c2c[nH]cn2)c1C CHEMBL1744281 Ki 0.75 nM
COc1ccc(Cl)cc1S(=O)(=O)N[C@H]1CC[C@@H](N2CCN(c3ccccc3OC(C)C)CC2)CC1 CHEMBL233816 Ki 0.75 nM
COc1ccccc1N1CCN(CCn2c(C)nc3c(sc4ccc(NC(=O)CCCC(=O)NCCc5ccccc5)cc43)c2=O)CC1 CHEMBL3298023 pKi 0.7586 nM
COc1ccc(S(=O)(=O)N[C@H]2CC[C@@H](N3CCC(c4ccccc4OC(C)C)CC3)CC2)cc1OC CHEMBL390129 Ki 0.77 nM
COc1ccccc1N1CCN(CCN2C(=O)CC3(CCCC3)CC2=O)CC1 CHEMBL13647 Ki 0.778 nM
Cc1ccsc1C(C)c1c[nH]cn1 CHEMBL170960 Ki 0.78 nM
CC(C)Oc1ccccc1N1CCN(C2CCC(N3C(=O)c4ccncc4C3=O)CC2)CC1 CHEMBL243229 Ki 0.8 nM
COc1ccc(Br)cc1S(=O)(=O)N[C@H]1CC[C@@H](N2CCN(c3ccccc3OC(C)C)CC2)CC1 CHEMBL233849 Ki 0.8 nM
COc1ccccc1N1CCN(CC2OCC(c3ccccc3)(c3ccccc3)O2)CC1 CHEMBL1242352 pKi 0.8128 nM
COc1ccccc1N1CCN(CC2COC(c3ccccc3)(c3ccccc3)O2)CC1 CHEMBL1946777 pKi 0.8128 nM
COc1ccccc1N1CCN(CC2COC(c3ccccc3)(c3ccccc3)O2)CC1 CHEMBL1963046 pKi 0.8128 nM
O=C1CC2(CCCC2)CC(=O)N1CCN1CCN(c2ccccc2F)CC1 CHEMBL299691 Ki 0.83 nM
COc1ccc(Cl)cc1N1CCN(CCn2c(C)nc3c(sc4ccccc43)c2=O)CC1 CHEMBL222896 Log Ki 0.8318 nM
COc1cc2nc(N3CCN(C(=O)C4CCCO4)CC3)nc(N)c2cc1OC CHEMBL611 Ki 0.85 nM
CNc1ccc2c(c1)C(NCCOc1cc(F)ccc1F)CCS2(=O)=O CHEMBL4218307 Ki 0.85 nM
N#Cc1cc(Cl)cc(Cn2cc(Cl)cc(C(N)=O)c2=N)c1 CHEMBL3800606 Ki 0.86 nM
COc1ccccc1OCCNCC(O)COc1cccc2[nH]c3ccccc3c12 CHEMBL723 Ki 0.883 nM
COc1cc2nc(N3CCN(C(=O)CCCCC4CCSS4)CC3)nc(N)c2cc1OC CHEMBL178923 Log Ki 0.8913 nM
CSc1ccc(C)cc1NCC1=NCCN1 CHEMBL72441 Log EC50 0.912 nM
COc1cccc(OC)c1OCCNCCOc1ccccc1OCc1ccccc1[N+](=O)[O-] CHEMBL200136 Log Ki 0.912 nM
COc1cccc(C)c1OCCNCCOc1ccccc1OCc1ccccc1 CHEMBL1254829 pKi 0.912 nM
COc1ccccc1N1CCN(CCn2c(=O)[nH]c3c(sc4ccc(NC(=O)Cc5ccccc5)cc43)c2=O)CC1 CHEMBL3298746 pKi 0.912 nM
COc1ccccc1N1CCN(CC2COC3(CCN(S(=O)(=O)c4cccc([N+](=O)[O-])c4)CC3)O2)CC1 CHEMBL3342871 pKi 0.912 nM
COc1ccccc1N1CCN(CCn2nc(-c3ccccc3)c(C(C)=O)c(N)c2=O)CC1 CHEMBL301726 Ki 0.93 nM
COc1cc2nc(N3CCN(C4=CC(=O)c5ccccc5C4=O)CC3)nc(N)c2cc1OC CHEMBL179743 Log Ki 0.9333 nM
O=C1CC2(CCCC2)CC(=O)N1CCN1CCN(c2cc(F)ccc2F)CC1 CHEMBL556313 Ki 0.95 nM
COc1ccc(C[C@@H](C)NCCOc2ccccc2OCC(F)(F)F)cc1S(N)(=O)=O CHEMBL1630940 pKi 0.955 nM
NC(=O)C1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1 CHEMBL1909072 Ki 0.955 nM
CC(c1c[nH]cn1)c1sccc1Br CHEMBL1237159 Ki 0.96 nM
COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(sc5cccnc54)c3=O)C[C@@H]21 CHEMBL40650 Ki 0.97 nM
CCC(c1c[nH]cn1)c1cscc1C CHEMBL1744287 Ki 0.97 nM
O=S(=O)(N[C@H]1CC[C@@H](N2CCC(c3ccccc3OCC(F)(F)F)CC2)CC1)c1cc(Cl)ccc1F CHEMBL228445 Ki 0.98 nM
COc1ccccc1N1CCN(CCn2c(=O)[nH]c3c(sc4ccc(NC(=O)CCCC(=O)NCCc5ccccc5)cc43)c2=O)CC1 CHEMBL3298017 pKi 1.0 nM
COc1ccccc1OCCNCC1CCOC(c2ccccc2)(c2ccccc2)O1 CHEMBL4467585 pKi 1.023 nM
COc1ccccc1N1CCN(CCN2C(=O)CC3(CCCC3)CC2=O)CC1 CHEMBL543741 pKi 1.047 nM
COc1ccc(Cl)cc1N1CCN(CCNc2cc(-c3ccccc3)nn(C)c2=O)CC1 CHEMBL81486 Ki 1.07 nM
c1ccc2sc(Cc3c[nH]cn3)cc2c1 CHEMBL1203851 Ki 1.1 nM
CS(=O)(=O)c1ccc(Cl)cc1Cn1cc(Cl)cc(C(N)=O)c1=N CHEMBL3799553 Ki 1.1 nM
CSc1ccc(Cl)cc1Cn1cc(Cl)cc(C(N)=O)c1=N CHEMBL4208816 Ki 1.1 nM
COc1ccccc1OCCNC[C@@H]1COCC(c2ccccc2)(c2ccccc2)O1 CHEMBL493486 pKi 1.148 nM
COc1ccccc1OCCNCC1COCC(c2ccccc2)(c2ccccc2)O1 CHEMBL2312227 pKi 1.148 nM
COc1ccccc1N1CCN(CCn2c(=O)[nH]c3c(sc4ccc(NC(=O)CCCCc5ccccc5)cc43)c2=O)CC1 CHEMBL3298748 pKi 1.175 nM
CCc1sc2ccc(Cl)c3c2c1CN(C)CC3 CHEMBL123448 Ki 1.2 nM
CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3cc(F)ccc3F)CC2)CC1 CHEMBL257097 Ki 1.2 nM
COc1cccc(OC)c1CCCNCCOc1ccccc1OCc1ccccc1 CHEMBL1254659 pKi 1.202 nM
COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1 CHEMBL142635 pKi 1.202 nM
c1ccc(OCCNCCOC(c2ccccc2)c2ccccc2)cc1 CHEMBL4462600 pKi 1.202 nM
COc1c(C)c(C)c(O)c(C)c1CN(C)CCOc1cc(C)c(O)cc1C(C)C CHEMBL25300 Log Ki 1.259 nM
COc1ccccc1N1CCN(CCn2c(=O)[nH]c3c(sc4ccccc43)c2=O)CC1 CHEMBL220781 Log Ki 1.259 nM
COc1ccccc1N1CCN(CCc2ccc3c(c2)OCO3)CC1 CHEMBL2220978 pKi 1.259 nM
C[C@H](CN1CCN(c2cc(F)c(F)cc2F)CC1)N1C(=O)CC2(CCCC2)CC1=O CHEMBL98241 Ki 1.3 nM
COc1cccc(CCN2CCN(c3ccccc3OC(C)C)CC2)c1 CHEMBL3946843 pKi 1.318 nM
COc1ccc(CCN2CCN(c3ccccc3OC(C)C)CC2)cc1OC CHEMBL3920110 pKi 1.349 nM
CCOc1ccccc1N1CCN(CCc2ccc(OC)cc2)CC1 CHEMBL3930616 pKi 1.349 nM
COc1ccccc1N1CCN(C[C@@H]2CO[C@@](CN3C(=O)CC4(CCCC4)CC3=O)(c3ccccc3)O2)CC1 CHEMBL1241557 pKi 1.38 nM
CC(C)Oc1ccccc1N1CCN([C@H]2CC[C@@H](NS(=O)(=O)c3cccc(C(F)(F)F)c3)CC2)CC1 CHEMBL233592 Ki 1.4 nM
COc1ccccc1N1CCN(C[C@@H]2CO[C@@](CN3CCCCC3=O)(c3ccccc3)O2)CC1 CHEMBL1242542 pKi 1.479 nM
COc1ccccc1N1CCN(CCCNC(=O)c2cccc3c(=O)c(C)c(-c4ccccc4)oc23)CC1 CHEMBL278865 Ki 1.5 nM
COc1ccccc1N1CCN(CCn2nc(-c3ccccc3)c3c(C)onc3c2=O)CC1 CHEMBL303464 Ki 1.5 nM
CC(C)Oc1ccccc1N1CCN(C2CCC(N3C(=O)c4cccnc4C3=O)CC2)CC1 CHEMBL243228 Ki 1.5 nM
CC(C)Oc1ccccc1N1CCN([C@H]2CC[C@@H](NS(=O)(=O)c3ccc(Cl)cc3F)CC2)CC1 CHEMBL233410 Ki 1.5 nM
CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3cccc(Cl)c3)CC2)CC1 CHEMBL257077 Ki 1.5 nM
COc1ccc2c(c1)C(NCCOc1cc(F)ccc1F)CCS2(=O)=O CHEMBL4213029 Ki 1.5 nM
COc1cc2nc(N3CCN(C(=O)c4ccc[nH]4)[C@H]4CCCC[C@H]43)nc(N)c2cc1OC CHEMBL389978 Log Ki 1.514 nM
CCOc1ccccc1N1CCN(CCc2ccc3c(c2)OCO3)CC1 CHEMBL3917716 pKi 1.514 nM
COc1ccc(Cl)cc1N1CCN(CCn2c(=O)[nH]c3c([nH]c4ccccc43)c2=O)CC1 CHEMBL386005 Log Ki 1.549 nM
COc1cc2nc(N3CCN(C(=O)c4ccc(Br)o4)[C@H]4CCCC[C@H]43)nc(N)c2cc1OC CHEMBL388884 Log Ki 1.549 nM
COc1cc2nc(N3CCN(C(=O)c4ccc(Br)o4)[C@H]4CCCC[C@@H]43)nc(N)c2cc1OC CHEMBL2261605 pKi 1.549 nM
COc1cc2nc(N(C)CCCCCCN(C)C(=O)C3COc4ccccc4O3)nc(N)c2cc1OC CHEMBL561851 pKi 1.585 nM
COC(=O)[C@@H]1[C@H]2C[C@H]3c4[nH]c5ccccc5c4CCN3C[C@@H]2CC[C@@H]1O CHEMBL15245 Ki 1.6 nM
C=Cc1sc2ccc(Cl)c3c2c1CN(C)CC3 CHEMBL25467 Ki 1.6 nM
COc1ccc(S(=O)(=O)N[C@H]2CC[C@@H](N3CCC(c4cc(F)ccc4OC(C)C)CC3)CC2)cc1OC CHEMBL228659 Ki 1.6 nM
COc1ccc(Cl)cc1S(=O)(=O)N[C@H]1CC[C@@H](N2CCC(c3ccccc3OCC(F)(F)F)CC2)CC1 CHEMBL442059 Ki 1.6 nM
CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3ccc(F)c(F)c3)CC2)CC1 CHEMBL256804 Ki 1.6 nM
C[C@H](c1cccc(C#N)c1)n1cc(Cl)cc(C(N)=O)c1=N CHEMBL3799292 Ki 1.6 nM
C[C@@H](c1cccc(CN)c1)n1cc(Cl)cc(C(N)=O)c1=N CHEMBL4753450 Ki 1.6 nM
COc1ccccc1N1CCN(CCn2c(=O)[nH]c3c(sc4ccc(NC(=O)CCCN(C)C)cc43)c2=O)CC1 CHEMBL3298019 pKi 1.66 nM
CC(Cc1cc2c(c(C(N)=O)c1)N(CCCO)CC2)NCCOc1ccccc1OCc1ccccc1 CHEMBL3808632 IC50 1.7 nM
CC(C)Oc1ccccc1N1CCN(CCc2ccc3c(c2)OCO3)CC1 CHEMBL3938038 pKi 1.738 nM
COc1ccccc1N1CCN(CC2COCC(c3ccccc3)(c3ccccc3)O2)CC1 CHEMBL4466677 pKi 1.738 nM
O=C1CC2(CCCC2)CC(=O)N1CCN1CCN(c2cc(F)c(F)cc2F)CC1 CHEMBL193620 Ki 1.9 nM
COc1ccc2ccoc2c1OCCNC[C@H]1COc2ccccc2O1 CHEMBL2419769 pKi 1.905 nM
CN(C)CCCN1c2ccccc2Sc2ccc(Cl)cc21 CHEMBL71 Ki 1.962 nM
C[C@H](Cc1cc2c(c(C(N)=O)c1)N(CCCO)CC2)NCCOc1ccccc1OCC(F)(F)F CHEMBL24778 Log Ki 1.995 nM
O=c1[nH]c2ccccc2c(=O)n1CCCN1CCN(c2ccccc2OCC(F)(F)F)CC1 CHEMBL56863 Log Ki 1.995 nM
COc1ccccc1COc1ccccc1OCCNCCOc1c(OC)cccc1OC CHEMBL198431 Log Ki 1.995 nM
COc1ccccc1N1CCN(CCCCN2C(=O)CC(c3ccccc3)CC2=O)CC1 CHEMBL1796033 pKi 1.995 nM
COc1ccc(S(=O)(=O)N[C@H]2CC[C@@H](N3CCC(c4ccccc4OC4CC4)CC3)CC2)cc1OC CHEMBL229085 Ki 2.0 nM
Cc1ccsc1C(C)c1c[nH]cn1 CHEMBL1237160 Ki 2.1 nM
O=S(=O)(N[C@H]1CC[C@@H](N2CCC(c3ccccc3OC3CC3)CC2)CC1)c1cc(Cl)ccc1F CHEMBL228280 Ki 2.1 nM
CC(C)Oc1ccccc1N1CCN([C@H]2CC[C@@H](NS(=O)(=O)c3ccc(OC(F)(F)F)cc3)CC2)CC1 CHEMBL236830 Ki 2.1 nM
COc1cc2nc(N3CCC[C@H](NC4=CC(=O)c5ccccc5C4=O)C3)nc(N)c2cc1OC CHEMBL4163587 pKi 2.138 nM
COc1ccc(S(=O)(=O)N[C@H]2CC[C@@H](N3CCC(c4ccccc4OCC(F)(F)F)CC3)CC2)cc1OC CHEMBL228334 Ki 2.2 nM
COc1ccc([N+](=O)[O-])cc1S(=O)(=O)N[C@H]1CC[C@@H](N2CCN(c3ccccc3OC(C)C)CC2)CC1 CHEMBL429623 Ki 2.2 nM
COc1ccc2c(c1OCCNC[C@H]1COc3ccccc3O1)OCC2 CHEMBL2419771 pKi 2.239 nM
COc1cc2nc(N3CCN(C(=O)Cc4ccc5ccccc5c4)[C@H]4CCCC[C@H]43)nc(N)c2cc1OC CHEMBL4125846 pKi 2.239 nM
COc1ccccc1N1CCN(CCn2c(C)nc3c(sc4ccc(NC(=O)CCCNC(=O)Cc5ccccc5)cc43)c2=O)CC1 CHEMBL3298024 pKi 2.291 nM
Cc1sccc1C(C)c1c[nH]cn1 CHEMBL1744269 Ki 2.3 nM
COc1cc2nc(N3CCN(C(=O)c4cccs4)[C@H]4CCCC[C@H]43)nc(N)c2cc1OC CHEMBL242724 Log Ki 2.344 nM
CC(C)Oc1ccccc1N1CCN([C@H]2CC[C@@H](NS(=O)(=O)c3ccccc3F)CC2)CC1 CHEMBL399195 Ki 2.4 nM
CC(C)Oc1ccccc1N1CCN([C@H]2CC[C@@H](NS(=O)(=O)c3ccccc3[N+](=O)[O-])CC2)CC1 CHEMBL232592 Ki 2.5 nM
COc1ccc(Cl)cc1N1CCN(CCCNc2nccc(C(N)=O)n2)CC1 CHEMBL24981 Log Ki 2.512 nM
Cc1c[nH]c(=O)n(CCN2CCN(c3ccc(F)cc3OCC(F)(F)F)CC2)c1=O CHEMBL293149 Log Ki 2.512 nM
COc1ccccc1N1CCN(C[C@@H]2CO[C@@](CN3CCCCCC3=O)(c3ccccc3)O2)CC1 CHEMBL1242633 pKi 2.512 nM
CCOc1ccccc1N1CCN(CCc2cccc(OC)c2)CC1 CHEMBL3947302 pKi 2.57 nM
COc1ccc(Cl)cc1S(=O)(=O)N[C@H]1CC[C@@H](N2CCC(c3ccccc3OC3CC3)CC2)CC1 CHEMBL388897 Ki 2.6 nM
CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3c(Cl)cccc3Cl)CC2)CC1 CHEMBL256597 Ki 2.6 nM
N=c1c(C(N)=O)cc(Cl)cn1Cc1cccc(Cl)c1 CHEMBL3800305 Ki 2.6 nM
CCOc1ccccc1OCCNC(C)Cc1cc(C(N)=O)c2c(ccn2CCCO)c1 CHEMBL3809248 IC50 2.6 nM
CSc1ccc(Cl)cc1NCC1=NCCN1 CHEMBL70751 Log EC50 2.692 nM
O=S(=O)(N[C@H]1CC[C@@H](N2CCC(c3ccccc3OCC(F)(F)F)CC2)CC1)c1ccc(OC(F)F)cc1 CHEMBL387832 Ki 2.7 nM
CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3ccc(F)cc3F)CC2)CC1 CHEMBL403280 Ki 2.7 nM
COc1ccc(Cl)cc1NC(=O)NC1CCC(N2CCN(c3ccccc3OC(C)C)CC2)CC1 CHEMBL271913 Ki 2.7 nM
COc1cccc(OC)c1[S+]([O-])CCNCCOc1ccccc1OCc1ccccc1 CHEMBL1254660 pKi 2.754 nM
c1ccc(-c2ccno2)c(NCC2=NCCN2)c1 CHEMBL155327 Log EC50 2.884 nM
CSc1ccc2c(c1)N(CCC1CCCCN1C)c1ccccc1S2 CHEMBL479 Ki 2.895 nM
COc1ccc(Cl)cc1N1CCN(CCCNc2cc(-c3ccccc3)nn(C)c2=O)CC1 CHEMBL78676 Ki 2.92 nM
O=S(=O)(N[C@H]1CC[C@@H](N2CCC(c3ccccc3OCC(F)(F)F)CC2)CC1)c1ccc2c(c1)OCCO2 CHEMBL439197 Ki 3.0 nM
CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3ccccc3Cl)CC2)CC1 CHEMBL257098 Ki 3.0 nM
COc1ccccc1N1CCN(CCNc2ccc3c4c(=O)n(C)nc(Cl)c4cn3n2)CC1 CHEMBL301078 Ki 3.04 nM
COc1ccc(CCN2CCN(c3ccccc3OC(C)C)CC2)cc1 CHEMBL3976144 pKi 3.09 nM
c1nc(Cc2ccsc2)c[nH]1 CHEMBL1744292 Ki 3.1 nM
COc1cc2nc(N(C)CCCNC(=O)C3CCCO3)nc(N)c2cc1OC CHEMBL709 Log Ki 3.162 nM
COc1ccccc1N1CCN(CCNc2c(C(C)=O)c(C)nn(C)c2=O)CC1 CHEMBL77901 Ki 3.2 nM
CC(C)Oc1ccccc1N1CCN([C@H]2CC[C@H](NS(=O)(=O)c3ccccc3C#N)CC2)CC1 CHEMBL234680 Ki 3.2 nM
COc1cc2nc(N3CCN(C(=O)c4ccccc4)[C@H]4CCCC[C@H]43)nc(N)c2cc1OC CHEMBL242934 Log Ki 3.236 nM
COc1cc2nc(N3CCN(C(=O)c4ccco4)[C@H]4CCCC[C@@H]43)nc(N)c2cc1OC CHEMBL2261604 pKi 3.236 nM
c1ccc(OCCNC[C@@H]2COCC(c3ccccc3)(c3ccccc3)O2)cc1 CHEMBL493285 pKi 3.236 nM
COc1ccccc1N1CCN(CCn2c(=O)[nH]c3c(sc4ccc(NC(=O)CCCc5ccccc5)cc43)c2=O)CC1 CHEMBL3298747 pKi 3.236 nM
CC(C)Oc1ccccc1N1CCN([C@H]2CC[C@@H](NS(=O)(=O)c3cccc(F)c3)CC2)CC1 CHEMBL232779 Ki 3.3 nM
COc1ccccc1N1CCN(CCn2c(C)nc3c(sc4ccc(NC(=O)Cc5ccccc5)cc43)c2=O)CC1 CHEMBL3298021 pKi 3.311 nM
COc1cccc(-c2ccccc2)c1OCCNC[C@H]1COc2ccccc2O1 CHEMBL215151 Log Ki 3.388 nM
CC(C)Oc1ccccc1N1CCN([C@H]2CC[C@@H](NS(=O)(=O)c3ccc(S(C)(=O)=O)cc3)CC2)CC1 CHEMBL236617 Ki 3.4 nM
CC(c1cccc(C#N)c1)n1cc(Cl)cc(C(N)=O)c1=N CHEMBL3800470 Ki 3.4 nM
COC(=O)[C@H]1[C@H]2C[C@H]3c4[nH]c5ccccc5c4CCN3C[C@H]2CC[C@@H]1O CHEMBL10347 Ki 3.5 nM
Cc1c(-c2ccccc2)oc2c(C(=O)NCCCN3CCN(c4ccccc4OCCCO[N+](=O)[O-])CC3)cccc2c1=O CHEMBL338029 Ki 3.5 nM
Cc1ccc(Cc2c[nH]cn2)s1 CHEMBL1203847 Ki 3.6 nM
CC(C)Oc1ccccc1N1CCN([C@H]2CC[C@@H](NS(=O)(=O)Cc3ccccc3)CC2)CC1 CHEMBL234649 Ki 3.6 nM
CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O CHEMBL1255837 Ki 3.622 nM
COc1cccc(OC)c1OCCNCCOc1ccccc1Cc1ccccc1 CHEMBL42558 Log Ki 3.631 nM
COc1ccc(C(=O)N2CCN(c3nc(N)c4cc(OC)c(OC)cc4n3)[C@@H]3CCCC[C@@H]32)o1 CHEMBL242508 Log Ki 3.631 nM
COc1ccc(C(=O)N2CCN(c3nc(N)c4cc(OC)c(OC)cc4n3)[C@H]3CCCC[C@@H]32)o1 CHEMBL2261607 pKi 3.631 nM
c1ccc(OCCNCC2COCC(c3ccccc3)(c3ccccc3)O2)cc1 CHEMBL2312537 pKi 3.631 nM
c1nc(Cc2cc3c(s2)CCCC3)c[nH]1 CHEMBL1203856 Ki 3.7 nM
CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3c(Cl)cc(Cl)cc3Cl)CC2)CC1 CHEMBL256040 Ki 3.7 nM
N=c1c(C(N)=O)cc(Cl)cn1Cc1cc(Cl)cc(C(N)=O)c1 CHEMBL3799912 Ki 3.7 nM
CCOc1ccccc1OCCNCCOc1ccccc1OCc1ccccc1 CHEMBL1254914 pKi 3.715 nM
CCCCCC(=O)N1CCN(c2nc(N)c3cc(OC)c(OC)cc3n2)[C@@H]2CCCC[C@@H]21 CHEMBL4127078 pKi 3.715 nM
COc1ccccc1N1CCN(CC2CCC(c3ccccc3)(c3ccccc3)O2)CC1 CHEMBL1946780 pKi 3.89 nM
Cc1c(-c2ccccc2)oc2c(C(=O)NCCCN3CCN(c4ccccc4OCc4no[n+]([O-])c4C#N)CC3)cccc2c1=O CHEMBL125989 Ki 3.9 nM
O=S1(=O)CCC(NCCOc2cc(F)ccc2Cl)c2ccccc21 CHEMBL4205740 Ki 3.9 nM
COc1ccc(Cl)cc1N1CCN(CCCNc2c(C(C)=O)c(-c3ccccc3)nn(C)c2=O)CC1 CHEMBL77618 Ki 3.92 nM
c1ccc(-c2nc[nH]n2)c(NCC2=NCCN2)c1 CHEMBL17491 Log EC50 3.981 nM
COc1ccccc1OCCNCCOc1ccccc1OCc1ccccc1 CHEMBL1254915 pKi 3.981 nM
COc1cccc(OC)c1OCCNC[C@@H]1COc2cccc(Cl)c2O1 CHEMBL2153556 pKi 3.981 nM
COc1cc2nc(N3CCN(C(=O)OCc4ccccc4)[C@H]4CCCC[C@H]43)nc(N)c2cc1OC CHEMBL4125981 pKi 3.981 nM
COc1ccccc1N1CCN(C[C@H]2CO[C@@](CN3CCCCCC3=O)(c3ccccc3)O2)CC1 CHEMBL1242632 pKi 4.074 nM
COc1ccccc1N1CCN(CCn2c(=O)[nH]c3c(sc4ccc(NC(=O)CCCN(C)Cc5ccccc5)cc43)c2=O)CC1 CHEMBL3298018 pKi 4.074 nM
Cc1ccccc1N1CCN(CCc2nnc3n2CCCC3)CC1 CHEMBL1201216 Ki 4.086 nM
COc1ccc(S(=O)(=O)N[C@H]2CC[C@@H](N3CCC(c4ccccc4OCC(F)F)CC3)CC2)cc1OC CHEMBL387833 Ki 4.1 nM
Cc1c(-c2ccccc2)oc2c(C(=O)NCCCN3CCN(c4ccccc4OCc4no[n+]([O-])c4C)CC3)cccc2c1=O CHEMBL338608 Ki 4.2 nM
CS(=O)(=O)c1ccccc1CNCCOc1cc(F)ccc1Cl CHEMBL4213993 Ki 4.3 nM
COc1ccccc1N1CCN(CCCNc2c(C(C)=O)c(-c3ccccc3)nn(C)c2=O)CC1 CHEMBL80260 Ki 4.32 nM
COc1ccccc1OCCNC[C@@H]1CO[C@H](C(c2ccccc2)c2ccccc2)O1 CHEMBL4526865 pKi 4.365 nM
COc1cccc(C2CCC(N3CCN(c4ccccc4OC)CC3)CC2)c1 CHEMBL2112779 Ki 4.49 nM
COc1ccccc1N1CCN(CCN(C(=O)C2CCCCC2)c2ccccn2)CC1 CHEMBL31354 pKi 4.571 nM
COc1ccccc1N1CCN(CCN(C(=O)C2CCCCC2)c2ccccn2)CC1 CHEMBL514874 pKi 4.571 nM
CC(C)Oc1ccccc1N1CCN(CCc2ccccc2)CC1 CHEMBL3967641 pKi 4.571 nM
COc1ccccc1N1CCN(CC2COC3(CCN(Cc4ccccc4)CC3)O2)CC1 CHEMBL3342853 pKi 4.677 nM
COc1cc2nc(N3CCN(C(=O)c4ccc(C)o4)[C@H]4CCCC[C@H]43)nc(N)c2cc1OC CHEMBL242507 Log Ki 4.786 nM
COc1ccccc1N1CCN(C[C@H]2CO[C@@](CN3C(=O)CC4(CCCC4)CC3=O)(c3ccccc3)O2)CC1 CHEMBL1242912 pKi 4.786 nM
COc1cc2nc(N3CCN(C(=O)c4ccc(C)o4)[C@H]4CCCC[C@@H]43)nc(N)c2cc1OC CHEMBL2261606 pKi 4.786 nM
CC(C)Oc1ccccc1N1CCN([C@H]2CC[C@@H](NS(=O)(=O)c3ccc(F)cc3)CC2)CC1 CHEMBL234874 Ki 4.8 nM
CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)Nc3c(F)cccc3F)CC2)CC1 CHEMBL270589 Ki 4.8 nM
CS(=O)(=O)c1cc(Cl)cc(Cn2cc(Cl)cc(C(N)=O)c2=N)c1 CHEMBL3800506 Ki 4.8 nM
Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2 CHEMBL85 Ki 4.913 nM
COc1ccc(F)cc1S(=O)(=O)N[C@H]1CC[C@@H](N2CCN(c3ccccc3OC(C)C)CC2)CC1 CHEMBL233814 Ki 5.0 nM
COc1ccccc1N1CCN(CCN(C(=O)C2CCCCC2)c2ccccn2)CC1 CHEMBL537403 Ki 5.0 nM
c1ccc(-c2ccoc2)c(OCC2=NCCN2)c1 CHEMBL142784 Log EC50 5.012 nM
CSc1cc(F)ccc1NCC1=NCCN1 CHEMBL306792 Log Ki 5.012 nM
COc1ccc(SC)c(NCC2=NCCN2)c1 CHEMBL70691 Log EC50 5.012 nM
c1ccc(-c2ncco2)c(NCC2=NCCN2)c1 CHEMBL155326 Log EC50 5.012 nM
Cc1[nH]c(=O)n(CCCN2CCN(c3ccccc3OCC(F)(F)F)CC2)c(=O)c1C CHEMBL292189 Log Ki 5.012 nM
COc1ccccc1N1CCN(CCCCN2C(=O)CC3(CCc4ccccc43)CC2=O)CC1 CHEMBL1796050 pKi 5.012 nM
COc1ccccc1N1CCN(CCn2c(C)nc3c(sc4ccc(NC(=O)c5ccccc5)cc43)c2=O)CC1 CHEMBL3298020 pKi 5.012 nM
Cc1ccccc1OCCNCC1COCC(c2ccccc2)(c2ccccc2)O1 CHEMBL4070363 pKi 5.012 nM
c1ccc(OCCNCC2CCOC(c3ccccc3)(c3ccccc3)O2)cc1 CHEMBL4582160 pKi 5.012 nM
COc1ccc(OC)c(S(=O)(=O)N[C@H]2CC[C@@H](N3CCN(c4ccccc4OC(C)C)CC3)CC2)c1 CHEMBL236832 Ki 5.1 nM
CCCN(CCC)c1nc(N2CCN(C(=O)c3ccco3)[C@H]3CCCC[C@H]32)nc2cc(OC)c(OC)cc12 CHEMBL4127483 pKi 5.129 nM
CC(C)Oc1ccccc1N1CCN([C@H]2CC[C@@H](NS(=O)(=O)c3ccccc3)CC2)CC1 CHEMBL391107 Ki 5.2 nM
COc1ccccc1N1CCN(C[C@@H]2CO[C@](CN3CCCC3=O)(c3ccccc3)O2)CC1 CHEMBL1242445 pKi 5.248 nM
COc1ccc(Cl)cc1N1CCN(CCCNc2c(C(C)=O)c(C)nn(C)c2=O)CC1 CHEMBL80599 Ki 5.34 nM
COCC1=C(C(=O)OC)[C@H](c2ccc(F)c(F)c2)N(C(=O)N[C@@H]2CC[C@@H](N3CCN(c4ccccc4C#N)CC3)C2)C(=O)N1 CHEMBL56974 Ki 5.4 nM
COc1ccccc1N1CCN(CCn2c(C)nc3c(sc4ccc(NC(=O)CCCC(=O)NCc5ccccc5)cc43)c2=O)CC1 CHEMBL3298022 pKi 5.495 nM
c1ccc(C2(c3ccccc3)COCC(CNCCOc3ccccn3)O2)cc1 CHEMBL4091168 pKi 5.495 nM
COc1ccc(S(=O)(=O)N[C@H]2CC[C@@H](N3CCC(c4ccccc4OCCF)CC3)CC2)cc1OC CHEMBL538397 Ki 5.5 nM
CC(C)Oc1ccccc1N1CCN([C@H]2CC[C@H](NS(=O)(=O)c3cccnc3)CC2)CC1 CHEMBL391016 Ki 5.5 nM
O=C1CC2(CCCC2)CC(=O)N1CCN1CCN(c2ccc(F)cc2F)CC1 CHEMBL446180 Ki 5.6 nM
COc1ccccc1OCCNC[C@H]1CCC(c2ccccc2)(c2ccccc2)[C@@H]1O CHEMBL1946786 pKi 5.754 nM
COc1ccccc1N1CCN(CC2COC3(CCN(S(=O)(=O)c4ccc([N+](=O)[O-])cc4)CC3)O2)CC1 CHEMBL3342870 pKi 5.754 nM
COc1ccccc1OCCNCCC1COC(c2ccccc2)(c2ccccc2)O1 CHEMBL4458714 pKi 5.754 nM
Clc1ccccc1OCCNCC1COCC(c2ccccc2)(c2ccccc2)O1 CHEMBL4075507 pKi 5.888 nM
COc1ccccc1OCCNCC(CO)OC(c1ccccc1)c1ccccc1 CHEMBL4439658 pKi 5.888 nM
O=S(=O)(N[C@H]1CC[C@@H](N2CCC(c3ccccc3OCC(F)(F)F)CC2)CC1)c1cccc(OC(F)F)c1 CHEMBL228496 Ki 5.9 nM
COc1cccc2c1CCCC2CCCN1CCN(c2ccccn2)CC1 CHEMBL444590 Ki 5.95 nM
COc1ccc(Cl)cc1N1CCN(CCCCNc2c(C(C)=O)c(C)nn(C)c2=O)CC1 CHEMBL420959 Ki 5.96 nM
CSc1ccc(F)cc1NCC1=NCCN1 CHEMBL72768 Log Ki 6.166 nM
COc1cc2nc(N3CCN(C(=O)C(C)(C)C)[C@H]4CCCC[C@H]43)nc(N)c2cc1OC CHEMBL4128460 pKi 6.166 nM
CN(C)CCCN1c2ccccc2Sc2ccccc21 CHEMBL564 Ki 6.18 nM
CC(C)Oc1ccccc1N1CCN([C@H]2CC[C@@H](NS(=O)(=O)c3cccc(Cl)c3F)CC2)CC1 CHEMBL233407 Ki 6.2 nM
CC(C)Oc1ccccc1N1CCN([C@H]2CC[C@@H](NS(=O)(=O)c3ccccc3C#N)CC2)CC1 CHEMBL234679 Ki 6.3 nM
c1c[nH]c(-c2ccccc2OCC2=NCCN2)c1 CHEMBL357129 Log EC50 6.31 nM
CC(C)Oc1ccccc1OCCNCC1COC(c2ccccc2)(c2ccccc2)O1 CHEMBL1078773 pKi 6.31 nM
COc1ccccc1OCCNCC1CCC(c2ccccc2)(c2ccccc2)O1 CHEMBL1946779 pKi 6.31 nM
COc1cccc(OC)c1OCCNCC1C(=O)c2ccccc2SC1c1ccccc1 CHEMBL98413 Log Ki 6.37 nM
Cn1nc(Cl)c2cn3nc(NCCN4CCN(c5ccccc5)CC4)ccc3c2c1=O CHEMBL51074 Ki 6.59 nM
COc1ccc2ccccc2c1OCCNC[C@H]1COc2ccccc2O1 CHEMBL217469 Log Ki 6.607 nM
COc1ccccc1OCCNCC1CSC(c2ccccc2)(c2ccccc2)O1 CHEMBL1083182 pKi 6.607 nM
O=[N+]([O-])c1ccccc1OCCNCC1COCC(c2ccccc2)(c2ccccc2)O1 CHEMBL4067083 pKi 6.607 nM
CCN([C@H]1CC[C@H](N2CCN(c3ccccc3OC(C)C)CC2)CC1)S(=O)(=O)c1ccc(OC)c(OC)c1 CHEMBL238401 Ki 6.7 nM
CCOc1ccccc1OCCNCC1COC(c2ccccc2)(c2ccccc2)O1 CHEMBL1078953 pKi 6.761 nM
COc1cccc(OC)c1OCCNCC1Oc2ccccc2CC1c1ccccc1 CHEMBL318257 Log Ki 6.86 nM
COc1cccc(OC)c1OCCNCC1C(=O)c2ccccc2CC1c1ccccc1 CHEMBL330599 Log Ki 6.88 nM
COc1cccc(OC)c1OCCNCC1=Cc2ccccc2OC1c1ccccc1 CHEMBL329035 Log Ki 6.95 nM
COc1ccc(C)cc1S(=O)(=O)N[C@H]1CC[C@@H](N2CCN(c3ccccc3OC(C)C)CC2)CC1 CHEMBL393725 Ki 7.0 nM
Clc1cccc(Cl)c1OCCNCCOc1ccccc1OCc1ccccc1 CHEMBL1255002 pKi 7.079 nM
COc1ccccc1N1CCN(CC2COC3(CCN(S(=O)(=O)c4ccc(Cl)cc4)CC3)O2)CC1 CHEMBL3342868 pKi 7.079 nM
COc1ccccc1OCCNC[C@H]1CO[C@H](C(c2ccccc2)c2ccccc2)O1 CHEMBL4570387 pKi 7.079 nM
COc1ccccc1N1CCN(CCCn2c(=O)[nH]c3scc(-c4ccccc4)c3c2=O)CC1 CHEMBL14199 Ki 7.15 nM
CC(C)Oc1ccccc1C1CCN([C@H]2CC[C@@H](NS(=O)(=O)c3ccc(F)c(F)c3)CC2)CC1 CHEMBL390184 Ki 7.3 nM
Cc1nc2c([nH]c3ccccc32)c(=O)n1CCN1CCN(c2ccc(Cl)c(Cl)c2)CC1 CHEMBL220717 Log Ki 7.413 nM
COc1cc2nc(N3CCN(C(=O)c4ccc(C(C)=O)o4)[C@H]4CCCC[C@H]43)nc(N)c2cc1OC CHEMBL242723 Log Ki 7.413 nM
COc1cccc(OC)c1OCCNC[C@@H]1COc2cccc(F)c2O1 CHEMBL2153558 pKi 7.413 nM
COc1cc2nc(N3CCN(C(=O)c4ccc(C(C)=O)o4)[C@H]4CCCC[C@@H]43)nc(N)c2cc1OC CHEMBL2261608 pKi 7.413 nM
COc1ccccc1OCCNCC1OCCOC1(c1ccccc1)c1ccccc1 CHEMBL4559278 pKi 7.413 nM
COCC1=C(C(=O)OC)[C@H](c2ccc(F)c(F)c2)N(C(=O)N[C@@H]2CC[C@H](N3CCN(c4ccccc4C#N)CC3)C2)C(=O)N1 CHEMBL300766 Ki 7.5 nM
Cc1cccc(Cn2cc(Cl)cc(C(N)=O)c2=N)c1 CHEMBL3799420 Ki 7.5 nM
Cc1ccc(N(CC2=NCCN2)c2cccc(O)c2)cc1 CHEMBL597 Ki 7.6 nM
O=C1CC2(CCCC2)CC(=O)N1CCN1CCN(c2ccc(F)c(F)c2)CC1 CHEMBL192099 Ki 7.9 nM
COc1cccc(OC)c1OCCNCC1C(=O)c2ccccc2OC1c1ccccc1 CHEMBL99489 Log Ki 7.93 nM
O[C@@H]1[C@H](NC[C@H]2COc3ccccc3O2)CC[C@H]1Oc1ccccc1 CHEMBL135973 Log Ki 7.943 nM
CSc1ccccc1NCC1=NCCN1 CHEMBL117248 Log EC50 7.943 nM
Cc1n[nH]c(=O)n(CCCN2CCN(c3ccccc3OCC(F)(F)F)CC2)c1=O CHEMBL55290 Log Ki 7.943 nM
COc1ccccc1CCNCc1ccc(CCNC[C@H](O)c2ccc(O)c3[nH]c(=O)sc23)cc1 CHEMBL1944694 pIC50 7.943 nM
COc1ccccc1N1CCN(CC2COC3(CCN(c4ccccc4)CC3)O2)CC1 CHEMBL3342857 pKi 8.128 nM
CCC(c1c[nH]cn1)c1sccc1C CHEMBL1744267 Ki 8.3 nM
COc1ccc(S(=O)(=O)N[C@H]2CC[C@H](N3CCN(c4ccccc4OCC(F)(F)F)CC3)CC2)cc1OC CHEMBL238402 Ki 8.3 nM
N#Cc1ccc(Cl)cc1Cn1cc(Cl)cc(C(N)=O)c1=N CHEMBL3799166 Ki 8.5 nM
COc1ccccc1N1CCN(C[C@@H]2CO[C@@](CN3C(=O)CCCC3=O)(c3ccccc3)O2)CC1 CHEMBL1242819 pKi 8.511 nM
CC(C)Oc1ccccc1N1CCN([C@H]2CC[C@H](NS(=O)(=O)c3ccc(Cl)cc3Cl)CC2)CC1 CHEMBL393104 Ki 8.6 nM
CS(=O)(=O)c1ccccc1CCNCCOc1cc(F)ccc1Cl CHEMBL4214499 Ki 8.6 nM
c1csc(Cc2c[nH]cn2)c1 CHEMBL1203849 Ki 8.7 nM
COc1ccccc1NC(=O)NC1CCC(N2CCN(c3ccccc3OC(C)C)CC2)CC1 CHEMBL272340 Ki 8.7 nM
COc1cccc(Cn2cc(Cl)cc(C(N)=O)c2=N)c1 CHEMBL3799089 Ki 8.7 nM
CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12 CHEMBL1385840 Ki 8.747 nM
CSc1ccccc1NCC1=NCCN1 CHEMBL540542 Log EC50 8.913 nM
COc1cccc(OC)c1OCCNC[C@H]1COc2cccc(O)c2O1 CHEMBL2153551 pKi 8.913 nM
COCC1=C(C(=O)OC)[C@H](c2ccc(F)c(F)c2)N(C(=O)N[C@H]2CC[C@H](N3CCN(c4ccccc4C#N)CC3)C2)C(=O)N1 CHEMBL278716 Ki 9.0 nM
O=C1NCCN1CCN1CCC(c2cn(-c3ccc(F)cc3)c3ccc(Cl)cc23)CC1 CHEMBL12713 Activity 9.0 nM
CS(=O)(=O)c1ccccc1CCCNCCOc1cc(F)ccc1Cl CHEMBL4209590 Ki 9.1 nM
COc1ccccc1OCCNCC1COC(c2ccccc2)(c2ccccc2)O1 CHEMBL286003 Log Ki 9.333 nM
COc1ccccc1OCCNCC1COC(c2ccccc2)(c2ccccc2)O1 CHEMBL1082862 pKi 9.333 nM
COc1ccncc1S(=O)(=O)N[C@H]1CC[C@@H](N2CCN(c3ccccc3OC(C)C)CC2)CC1 CHEMBL232607 Ki 9.4 nM
CS(=O)(=O)c1ccc(Cn2cc(Cl)cc(C(N)=O)c2=N)cc1Cl CHEMBL3799869 Ki 9.4 nM
COc1cccc2c1C(NCCOc1cc(F)ccc1F)CCS2(=O)=O CHEMBL4217958 Ki 9.5 nM
[2H]c1c([2H])c([2H])c([C@@H]2C[C@@H](N3CCN(C([2H])([2H])[2H])C(C)(C)C3)c3cc(Cl)ccc32)c([2H])c1[2H] CHEMBL5191141 Ki 9.5 nM
COc1ccccc1N1CCN(CC2COC3(CCN(S(=O)(=O)c4cccs4)CC3)O2)CC1 CHEMBL3342872 pKi 9.772 nM
COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCN(c3ccccc3C)CC2)C1c1ccc(F)c(F)c1 CHEMBL344525 Ki 9.8 nM
CNC(=O)c1ccccc1NCC1=NCCN1 CHEMBL95523 Log EC50 10.0 nM
COc1ccccc1N1CCN(CCCNc2c(C)c(=O)n(C)c(=O)n2C)CC1 CHEMBL420060 Log Ki 10.0 nM
CC(C)Oc1ccccc1N1CCN(CCCNC(=O)c2ccc3c(c2)C(=O)N(c2ccc(O)cc2)C3=O)CC1 CHEMBL70892 Ki 10.0 nM
O=c1[nH]cc(Cl)c(=O)n1CCCN1CCN(c2ccc(F)cc2OCC(F)(F)F)CC1 CHEMBL298838 Log Ki 10.0 nM
N#Cc1cccc(Cn2cc(Cl)cc(C(N)=O)c2=N)c1 CHEMBL3798655 Ki 10.0 nM
COc1ccccc1OCCNCCOC(c1ccccc1)c1ccccc1 CHEMBL4468507 pKi 10.0 nM
CS(=O)(=O)c1ccccc1N1CCN(CCc2ccc(CN3C(=O)c4ccccc4C3=O)cc2)CC1 CHEMBL3742276 IC50 10.07 nM
COc1cccc(OC)c1OCCNC[C@@H]1COc2ccccc2O1 CHEMBL214986 Log Ki 10.47 nM
COc1cccc(OC)c1OCCNC[C@@H]1COc2ccccc2O1 CHEMBL36622 pKi 10.47 nM
COc1cccc(OC)c1OCCNC[C@@H]1COc2ccccc2O1 CHEMBL3740374 pKi 10.47 nM
COc1cc(F)ccc1OCCNC(C)Cc1cc(C(N)=O)c2c(ccn2CCCO)c1 CHEMBL3809676 IC50 10.6 nM
COc1ccccc1N1CCN(CC2COC3(CCN(S(=O)(=O)c4ccc(C)cc4)CC3)O2)CC1 CHEMBL3342867 pKi 10.72 nM
COc1ccccc1N1CCN(CC2COC3(CCN(C(=O)c4ccc(C(F)(F)F)cc4)CC3)O2)CC1 CHEMBL3342860 pKi 10.96 nM
COCC1=C(C(=O)OC)[C@H](c2ccc(F)c(F)c2)N(C(=O)N[C@H]2CC[C@H](N3CCC(c4ccccc4C#N)CC3)C2)C(=O)N1 CHEMBL433832 Ki 11.0 nM
Cc1ccc(S(=O)(=O)N[C@H]2CC[C@@H](N3CCN(c4ccccc4OC(C)C)CC3)CC2)cc1Cl CHEMBL234423 Ki 11.0 nM
COc1ccc(Cl)cc1S(=O)(=O)N[C@H]1CC[C@H](N2CCN(c3ccccc3OC(C)C)CC2)CC1 CHEMBL234607 Ki 11.0 nM
N#Cc1ccc(Cn2cc(Cl)cc(C(N)=O)c2=N)cc1Cl CHEMBL3799115 Ki 11.0 nM
O=C1c2ccccc2C(=O)N1Cc1ccc(CCN2CCN(c3ccccn3)CC2)cc1 CHEMBL3739533 IC50 11.31 nM
c1ccc(OCCNCC2COC(c3ccccc3)(c3ccccc3)O2)cc1 CHEMBL37883 Log Ki 11.48 nM
c1ccc(OCCNCC2COC(c3ccccc3)(c3ccccc3)O2)cc1 CHEMBL1083181 pKi 11.48 nM
COc1ccccc1N1CCN(CCNc2cc(-c3ccccc3)nn(C)c2=O)CC1 CHEMBL311479 Ki 11.78 nM
COc1ccccc1N1CCN(CCCNc2cc(-c3ccccc3)nn(C)c2=O)CC1 CHEMBL78785 Ki 11.79 nM
Cn1nc(Cl)c2cn3nc(NCCN4CCN(c5ccccc5Cl)CC4)ccc3c2c1=O CHEMBL49851 Ki 11.9 nM
COc1ccccc1N1CCN(Cc2ccc(CN3CCCCC3=O)s2)CC1 CHEMBL420184 Ki 12.0 nM
COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCN(c3ccccc3C#N)CC2)C1c1ccc(F)c(F)c1 CHEMBL145190 Ki 12.0 nM
CC(C)c1cc(Cc2c[nH]cn2)c(C(C)C)s1 CHEMBL1744274 Ki 12.0 nM
COc1ccc(S(=O)(=O)N[C@H]2CC[C@@H](N3CCC(c4ccc(F)cc4OC(C)C)CC3)CC2)cc1OC CHEMBL228608 Ki 12.0 nM
CC(C)Oc1ccccc1N1CCN([C@H]2CC[C@H](NS(=O)(=O)Cc3ccccc3)CC2)CC1 CHEMBL234650 Ki 12.0 nM
O=S1(=O)CCC(NCCOc2cc(F)ccc2F)c2cc(F)ccc21 CHEMBL4218841 Ki 12.0 nM
COc1ccccc1N1CCN(CC2COC3(CCN(S(=O)(=O)c4ccccc4)CC3)O2)CC1 CHEMBL3342866 pKi 12.3 nM
COc1cccc2c(CCCN3CCN(c4ccccn4)CC3)cccc12 CHEMBL139505 Ki 12.57 nM
c1ccc(-c2ccsc2)c(OCC2=NCCN2)c1 CHEMBL422477 Log EC50 12.59 nM
Cc1c[nH]c(=O)n(CCCN2CCN(c3ccccc3OCC(F)(F)F)CC2)c1=O CHEMBL56331 Log Ki 12.59 nM
O=c1[nH]c2c(O)ccc([C@@H](O)CNCCc3ccc(CNCCc4ccccc4)cc3)c2s1 CHEMBL1944695 pIC50 12.59 nM
COc1cccc2c1CCCC2CCCNCCOc1ccccn1 CHEMBL344432 Ki 12.65 nM
O=C1c2ccccc2C(=O)N1Cc1ccc(CCN2CCN(c3ccc(C(F)(F)F)cc3)CC2)cc1 CHEMBL3742253 IC50 12.87 nM
COc1ccc2c(c1OCCNC[C@H]1COc3ccccc3O1)NCC2 CHEMBL3216590 pKi 12.88 nM
COc1ccccc1N1CCN(Cc2ccc(CN3CCCCCC3=O)s2)CC1 CHEMBL69339 Ki 13.0 nM
O=S(=O)(N[C@H]1CC[C@@H](N2CCC(c3ccccc3OC3CC3)CC2)CC1)c1ccc2c(c1)OCO2 CHEMBL389104 Ki 13.0 nM
COc1ccccc1N1CCN(CC2COC3(CCN(C(=O)Nc4ccccc4)CC3)O2)CC1 CHEMBL3342874 pKi 13.18 nM
COc1cc2nc(N3CCC[C@H](NC(=O)[C@@H]4COc5ccccc5O4)C3)nc(N)c2cc1OC CHEMBL4160032 pKi 13.18 nM
CC(Cc1cc2c(c(C(N)=O)c1)N(CCCO)CC2)NCCOc1ccccc1OCC(F)(F)F CHEMBL3187195 IC50 13.4 nM
COc1ccc(Cl)cc1N1CCN(CCn2c(=O)[nH]c3c(sc4ccccc43)c2=O)CC1 CHEMBL223289 Log Ki 13.49 nM
COc1ccccc1N1CCN(C[C@H]2CO[C@](CN3CCCC3=O)(c3ccccc3)O2)CC1 CHEMBL1242444 pKi 13.49 nM
COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCN(c3ccccc3Cl)CC2)C1c1ccc(F)c(F)c1 CHEMBL142398 Ki 14.0 nM
CCOc1ccccc1N1CCN(CCCNC(=O)N2C(=O)NC(C)=C(C(=O)OC)C2c2ccc(F)c(F)c2)CC1 CHEMBL142251 Ki 14.0 nM
O=C1CC2(CCCC2)CC(=O)N1CCN1CCN(c2ccc(F)cc2)CC1 CHEMBL57546 Ki 14.0 nM
COc1ccc(C(F)(F)F)cc1S(=O)(=O)N[C@H]1CC[C@@H](N2CCN(c3ccccc3OC(C)C)CC2)CC1 CHEMBL234231 Ki 14.0 nM
CN1C[C@H](C(=O)N[C@]2(C)O[C@@]3(O)[C@@H]4CCCN4C(=O)[C@H](Cc4ccccc4)N3C2=O)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21 CHEMBL1732 Ki 14.0 nM
COc1ccccc1N1CCN(C[C@H]2CO[C@@](CN3CCCCC3=O)(c3ccccc3)O2)CC1 CHEMBL1242541 pKi 14.13 nM
Cc1cccc(C)c1OCCNCCOc1ccccc1OCc1ccccc1 CHEMBL1255003 pKi 14.13 nM
COc1ccc2c(c1OCCNC[C@H]1COc3ccccc3O1)CCCC2 CHEMBL383938 Log Ki 14.45 nM
c1ccc(OCCNC[C@H]2COC(c3ccccc3)(c3ccccc3)O2)cc1 CHEMBL3739932 pKi 14.45 nM
CC(C)Oc1ccccc1N1CCN([C@H]2CC[C@H](NS(=O)(=O)c3cnc(Cl)c(Br)c3)CC2)CC1 CHEMBL233790 Ki 14.6 nM
COc1ccccc1N1CCN(CC2COC3(CCSCC3)O2)CC1 CHEMBL3342852 pKi 14.79 nM
COC(=O)[C@@H]1CCCN1Cc1ccc(CN2CCN(c3ccccc3OC)CC2)s1 CHEMBL68241 Ki 15.0 nM
CC(C)Oc1ccccc1N1CCN(CCCNC(=O)c2ccc3c(c2)C(=O)N(c2ccc(N(C)C)cc2)C3=O)CC1 CHEMBL69264 Ki 15.0 nM
CC(C)Oc1ccccc1N1CCN([C@H]2CC[C@@H](NS(=O)(=O)c3cc(Cl)ccc3F)CC2)CC1 CHEMBL394139 Ki 15.0 nM
COc1ccc(C(F)(F)F)cc1S(=O)(=O)N[C@H]1CC[C@H](N2CCN(c3ccccc3OC(C)C)CC2)CC1 CHEMBL234232 Ki 15.0 nM
CC(C)Oc1ccccc1N1CCN(C2CCC(NC(=O)NCc3cccc(F)c3)CC2)CC1 CHEMBL256041 Ki 15.0 nM
CC(C)C[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]c(Br)c(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12 CHEMBL493 Ki 15.0 nM
CN1CCC[C@@H]1CCO[C@](C)(c1ccccc1)c1ccc(Cl)cc1 CHEMBL1626 Ki 15.0 nM
CC(c1cccc(S(C)(=O)=O)c1)n1cc(Cl)cc(C(N)=O)c1=N CHEMBL3800449 Ki 15.0 nM
COc1ccc(-c2ccccc2)cc1OCCNC[C@H]1COc2ccccc2O1 CHEMBL214694 Log Ki 15.14 nM
Oc1cccc(O)c1OCCNCCOc1ccccc1OCc1ccccc1 CHEMBL1255085 pKi 15.14 nM
COc1ccc(C[C@@H](C)NC[C@@H]2Oc3ccccc3O[C@@H]2C)cc1S(N)(=O)=O CHEMBL1630942 pKi 15.49 nM
COc1ccccc1OCCNC(C)Cc1cc2c(c(C(N)=O)c1)N(CCCO)CC2 CHEMBL3808408 IC50 15.8 nM
CC(C)CNC(=O)c1ccccc1NCC1=NCCN1 CHEMBL95565 Log EC50 15.85 nM
CCCCOC(=O)c1ccccc1NCC1=NCCN1 CHEMBL99559 Log EC50 15.85 nM
CC(C)(Cc1c[nH]c2ccc(Cl)cc12)NCCOc1ccccc1OCC1CC1 CHEMBL88272 Log Ki 15.85 nM
c1csc(-c2ccccc2OCC2=NCCN2)c1 CHEMBL143801 Log EC50 15.85 nM
Cn1ccc(-c2ccccc2NCC2=NCCN2)n1 CHEMBL17856 Log EC50 15.85 nM
Cc1c[nH]c(=O)n(CC2(CN3CCN(c4ccccc4OCC(F)(F)F)CC3)CC2)c1=O CHEMBL55629 Log Ki 15.85 nM
COc1cc2nc3c(c(N)c2cc1OC)CCC(CNC(=O)c1ccco1)C3 CHEMBL144286 Log Ki 15.85 nM
COc1ccc2c(c1OCCNC[C@@H]1COc3ccccc3O1)CCCC2 CHEMBL217143 Log Ki 15.85 nM
COc1ccccc1OCCNCC[C@H]1CO[C@H](C(c2ccccc2)c2ccccc2)O1 CHEMBL4551941 pKi 15.85 nM
COC(c1c[nH]cn1)c1cscc1C CHEMBL1744286 Ki 15.9 nM
CC(Cc1cc(C(N)=O)c2c(ccn2CCCO)c1)NCCOc1ccccc1OCC(F)(F)F CHEMBL3808572 IC50 15.9 nM
COCC1=C(C(=O)OC)[C@H](c2ccc(F)c(F)c2)N(C(=O)N[C@@H]2CC[C@H](N3CCC(c4ccccc4C#N)CC3)C2)C(=O)N1 CHEMBL300540 Ki 16.0 nM
O=C1c2ccccc2C(=O)N1CCCCN1CCC(n2c(O)nc3ccccc32)CC1 CHEMBL311247 Ki 16.0 nM
COc1ccc(N2C(=O)c3ccc(C(=O)NCCCN4CCN(c5ccccc5OC(C)C)CC4)cc3C2=O)cc1 CHEMBL304591 Ki 16.0 nM
Cc1ccc(S(=O)(=O)N[C@H]2CC[C@H](N3CCN(c4ccccc4OC(C)C)CC3)CC2)cc1Cl CHEMBL234609 Ki 16.0 nM
OCCN1CCN(CCCN2c3ccccc3Sc3ccc(C(F)(F)F)cc32)CC1 CHEMBL726 Ki 16.0 nM
CN1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1 CHEMBL728 Ki 16.0 nM
Fc1ccc2c(C3CCN(CCCN4CCc5ccccc5C4)CC3)c[nH]c2c1 CHEMBL3609360 Ki 16.0 nM
N=c1c(C(N)=O)cc(Cl)cn1CCc1ccccc1 CHEMBL3800219 Ki 16.0 nM
O[C@@H]1[C@H](NC[C@@H]2COc3ccccc3O2)CC[C@H]1Oc1ccccc1 CHEMBL134428 Log Ki 16.22 nM
c1coc(-c2ccccc2NCC2=NCCN2)c1 CHEMBL152155 Log EC50 16.22 nM
COc1ccccc1OCCNC[C@@H]1CO[C@H](c2ccccc2)CO1 CHEMBL521665 pKi 16.22 nM
COc1ccccc1N1CCN(C[C@@H]2CO[C@@](CN3C(=O)CCC3=O)(c3ccccc3)O2)CC1 CHEMBL1242725 pKi 16.22 nM
O=C1CC2(CCCC2)CC(=O)N1CCN1CCN(c2ccccc2O)CC1 CHEMBL59315 pKi 16.22 nM
COc1cccc(OC)c1OCCNC[C@@H]1COc2cccc(OC)c2O1 CHEMBL2153554 pKi 16.6 nM
COc1ccccc1N1CCN(CCc2ccccc2)CC1 CHEMBL27021 pKi 16.6 nM
COc1ccccc1OCCNCC[C@@H]1CO[C@H](C(c2ccccc2)c2ccccc2)O1 CHEMBL4579802 pKi 16.6 nM
[C-]#[N+]c1ccccc1N1CCN(CCc2ccc(CN3C(=O)c4ccccc4C3=O)cc2)CC1 CHEMBL3739762 IC50 16.73 nM
COc1cccc(OC)c1OCCNCC1Cc2ccccc2C(c2ccccc2)C1 CHEMBL42231 Log Ki 16.98 nM
CN1CCN(C2=Nc3cc(Cl)ccc3Nc3ccccc32)CC1 CHEMBL42 Ki 17.0 nM
O=S1(=O)CCC(NCCOc2cc(F)ccc2F)c2ccccc21 CHEMBL4217445 Ki 17.0 nM
CS(=O)(=O)c1ccc(Cl)cc1CNCCOc1cc(F)ccc1Cl CHEMBL4213747 Ki 17.0 nM
COc1ccc(C[C@@H](C)NC[C@H]2Oc3ccccc3O[C@H]2C)cc1S(N)(=O)=O CHEMBL1630941 pKi 17.38 nM
COc1cccc(N(NC2=NCCN2)c2ccc(C)cc2)c1 CHEMBL362954 Ki 17.5 nM
COc1ccccc1N1CCN(CCNc2cc(C)nn(C)c2=O)CC1 CHEMBL80132 Ki 17.69 nM
c1ccc(COc2ccccc2OCCNCCOc2ccccc2)cc1 CHEMBL1255086 pKi 17.78 nM
Cc1noc(C)c1S(=O)(=O)Nc1ccc2c(c1)C(=O)CC1(CCN(CCc3cccc4ccccc34)CC1)O2 CHEMBL101610 Ki 18.0 nM
CC(C)Oc1ccccc1N1CCN(Cc2ccc(CN3CCCCC3=O)s2)CC1 CHEMBL305029 Ki 18.0 nM
c1csc(-c2ccccc2NCC2=NCCN2)c1 CHEMBL346380 Log EC50 18.2 nM
COc1ccc2c(c1OCCNC[C@@H]1COc3ccccc3O1)OCC2 CHEMBL2419772 pKi 18.2 nM
COc1ccc2ccoc2c1OCCNC[C@@H]1COc2ccccc2O1 CHEMBL2419770 pKi 18.2 nM
CC(C)Oc1ccccc1N1CCN([C@H]2CC[C@H](NS(=O)(=O)c3ccc(Cl)cc3F)CC2)CC1 CHEMBL233582 Ki 19.0 nM
COc1ccccc1N1CCN(CCN(C(=O)C23CCC(CF)(CC2)C3)c2ccccn2)CC1 CHEMBL1910141 Ki 19.0 nM
COc1cc2nc3c(c(N)c2cc1OC)CCC(CNC(=O)c1ccc(C(F)(F)F)cc1)C3 CHEMBL143026 Log Ki 19.05 nM
CCCCNC(=O)N1CCC2(CC1)OCC(CN1CCN(c3ccccc3OC)CC1)O2 CHEMBL3342875 pKi 19.05 nM
c1ccc(-c2cc[nH]n2)c(NCC2=NCCN2)c1 CHEMBL277375 Log EC50 19.95 nM
c1ccc(-c2cn[nH]c2)c(NCC2=NCCN2)c1 CHEMBL275844 Log EC50 19.95 nM
CSc1ccccc1NCc1c[nH]cn1 CHEMBL118055 Log EC50 19.95 nM
Cc1cn(CCCN2CCN(c3ccccc3OCC(F)(F)F)CC2)c(=O)[nH]c1=O CHEMBL292403 Log Ki 19.95 nM
CC(C)(C)c1ccc(N2CCN(CCn3c(=O)[nH]c4c([nH]c5ccccc54)c3=O)CC2)cc1 CHEMBL319972 pKi 19.95 nM
COc1ccc(NC(=O)NC2CCC(N3CCN(c4ccccc4OC(C)C)CC3)CC2)c(OC)c1 CHEMBL256853 Ki 20.0 nM
CCN(CC)C(=O)N[C@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2N(C)C1 CHEMBL157138 Ki 20.0 nM
Cc1c(-c2ccccc2)oc2c(C(=O)NCCCN3CCN(c4ccccc4OCc4no[n+]([O-])c4C(N)=O)CC3)cccc2c1=O CHEMBL125365 Ki 20.4 nM
COc1ccccc1OCCNCC1CSC(c2ccccc2)(c2ccccc2)S1 CHEMBL1086156 pKi 20.42 nM
COc1ccccc1N1CCN(CC2COC3(CCN(C(=O)c4ccccc4)CC3)O2)CC1 CHEMBL3342859 pKi 20.42 nM
COc1cc2nc(N3CCN(C(=S)Nc4ccc(-c5c6ccc(=O)cc-6oc6cc(O)ccc56)c(C(=O)O)c4)CC3)nc(N)c2cc1OC CHEMBL3582271 Ki 20.7 nM
COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCN(c3ccccc3)CC2)C1c1ccc(F)c(F)c1 CHEMBL342731 Ki 21.0 nM
CC(Cc1cc(C(N)=O)c2c(ccn2CCCO)c1)NCCOc1ccc(F)cc1Br CHEMBL3808511 IC50 21.7 nM
CC(C)Oc1ccccc1N1CCN(CCCNC(=O)c2ccc3c(c2)C(=O)N(c2cccc(F)c2)C3=O)CC1 CHEMBL67552 Ki 22.0 nM
Fc1ccc2c(C3CCN(CCCN4CCCCC4)CC3)c[nH]c2c1 CHEMBL541129 Ki 22.0 nM
COc1ccc([N+](=O)[O-])cc1S(=O)(=O)N[C@H]1CC[C@H](N2CCN(c3ccccc3OC(C)C)CC2)CC1 CHEMBL234422 Ki 22.0 nM
CC(C)Oc1ccccc1N1CCN([C@H]2CC[C@H](NS(=O)(=O)c3ccc(S(C)(=O)=O)cc3)CC2)CC1 CHEMBL236618 Ki 22.0 nM
CCN([C@H]1CC[C@@H](N2CCN(c3ccccc3OC(C)C)CC2)CC1)S(=O)(=O)c1ccc(OC)c(OC)c1 CHEMBL429453 Ki 22.0 nM
COc1ccc2ccccc2c1OCCNC[C@@H]1COc2ccccc2O1 CHEMBL439346 Log Ki 22.39 nM
COc1cccc(OC)c1OCCNC[C@H]1C[C@H](c2ccccc2)c2ccccc2S1 CHEMBL40325 Log Ki 22.91 nM
COc1ccccc1N1CCN(CC2COC3(CCN(c4ccccn4)CC3)O2)CC1 CHEMBL3342858 pKi 22.91 nM
c1ccc(OCCNC[C@@H]2COC(c3ccccc3)(c3ccccc3)O2)cc1 CHEMBL3739897 pKi 22.91 nM
COc1ccccc1N1CCN(Cc2ccc(CN3CCCC3=O)s2)CC1 CHEMBL70178 Ki 23.0 nM
COc1ccc(S(=O)(=O)N[C@H]2CC[C@H](N3CCC(c4ccccc4OCC(F)(F)F)CC3)CC2)cc1OC CHEMBL228389 Ki 23.0 nM
N=c1c(C(N)=O)cc(Cl)cn1Cc1ccc(Cl)cc1 CHEMBL3797369 Ki 23.0 nM
COc1ccccc1N1CCN(CC2COC3(CCN(S(C)(=O)=O)CC3)O2)CC1 CHEMBL3342873 pKi 23.44 nM
Cn1cnc(S(=O)(=O)Nc2ccc3c(c2)C(=O)CC2(CCN(CCc4cccc5ccccc45)CC2)O3)c1 CHEMBL101579 Ki 24.0 nM
CC(C)Oc1ccccc1N1CCN([C@H]2CC[C@H](NS(=O)(=O)c3cccc(Cl)c3F)CC2)CC1 CHEMBL393105 Ki 24.0 nM
COc1ccc(S(=O)(=O)N[C@H]2CC[C@H](N3CCN(c4ccccc4OC(C)C)CC3)CC2)cc1OC CHEMBL236621 Ki 24.0 nM
CC(C)C[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12 CHEMBL1403281 Ki 24.0 nM
CN1C[C@H](C(=O)N[C@]2(C)O[C@@]3(O)[C@@H]4CCCN4C(=O)[C@H](Cc4ccccc4)N3C2=O)C=C2c3cccc4[nH]cc(c34)C[C@H]21 CHEMBL442 Ki 24.0 nM
CC(C)Oc1ccccc1N1CCN([C@H]2CC[C@H](NS(=O)(=O)c3cccc(F)c3)CC2)CC1 CHEMBL232780 Ki 24.5 nM
COc1cc2nc3c(c(N)c2cc1OC)CCC(CNC(=O)c1ccccc1C(F)(F)F)C3 CHEMBL145785 Log Ki 24.55 nM
O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCC(n2c(=O)oc3cc(F)ccc32)CC1 CHEMBL83272 Ki 25.0 nM
CC(C)Oc1ccccc1N1CCN(Cc2cc(CN3CCCC3=O)cs2)CC1 CHEMBL69848 Ki 25.0 nM
COc1cc2c(cc1O)CCN1Cc3c(ccc(O)c3OC)C[C@@H]21 CHEMBL320397 Ki 25.0 nM
COc1ccc(CCN2CCC(c3nc(COCC(F)(F)F)c(-c4ccc(F)cc4)o3)CC2)cc1S(N)(=O)=O CHEMBL267336 Log Ki 25.12 nM
c1ccc(-c2ccns2)c(OCC2=NCCN2)c1 CHEMBL142387 Log EC50 25.12 nM
CCc1c[nH]c(=O)n(CCCN2CCN(c3ccc(F)cc3OCC(F)(F)F)CC2)c1=O CHEMBL53675 Log Ki 25.12 nM
O=c1[nH]cc(F)c(=O)n1CCCN1CCN(c2ccc(F)cc2OCC(F)(F)F)CC1 CHEMBL417954 Log Ki 25.12 nM
COc1cc2nc3c(c(N)c2cc1OC)CCC(CNC(=O)c1cccc(C(F)(F)F)c1)C3 CHEMBL2112853 Log Ki 25.12 nM
O=c1[nH]c2c(O)ccc([C@@H](O)CNCCc3ccc(CNCCc4ccccn4)cc3)c2s1 CHEMBL1945034 pIC50 25.12 nM
O=c1[nH]c2c(O)ccc([C@@H](O)CNCCOc3cccc(CNCCc4ccccc4F)c3)c2s1 CHEMBL1945298 pIC50 25.12 nM
COc1ccccc1CNCCc1cccc(CCNC[C@H](O)c2ccc(O)c3[nH]c(=O)sc23)c1 CHEMBL1945299 pIC50 25.12 nM
COc1ccccc1OCCNC[C@H]1COCC(c2ccccc2)(c2ccccc2)O1 CHEMBL2312536 pKi 25.12 nM
COc1ccccc1N1CCN(CC2COC3(CCOCC3)O2)CC1 CHEMBL3341769 pKi 25.12 nM
COc1ccccc1OCCNCC1COC(c2ccccc2)(c2ccccc2)OC1 CHEMBL4588223 pKi 25.12 nM
Cc1ccccc1OCCNCC1COC(c2ccccc2)(c2ccccc2)O1 CHEMBL1084658 pKi 25.7 nM
O=S(=O)(N[C@H]1CC[C@H](N2CCC(c3ccccc3OCC(F)(F)F)CC2)CC1)c1ccc2c(c1)OCCO2 CHEMBL228390 Ki 26.0 nM
CN1[C@@H]2CC[C@H]1C[C@@H](OC(c1ccccc1)c1ccccc1)C2 CHEMBL1201203 Ki 26.0 nM
N=c1c(C(N)=O)cc(Cl)cn1Cc1cccc(C(N)=O)c1 CHEMBL3799486 Ki 26.0 nM
COc1cc2nc(N3CCN(C(=O)C4COc5ccccc5O4)[C@H]4CCCC[C@@H]43)nc(N)c2cc1OC CHEMBL549764 pKi 26.3 nM
COc1ccccc1N1CCN(CC2COC3(CCN(S(=O)(=O)c4ccc(OC(F)(F)F)cc4)CC3)O2)CC1 CHEMBL3342869 pKi 26.3 nM
COc1cc2nc(N3CCN(C(=O)c4ccccn4)[C@H]4CCCC[C@H]43)nc(N)c2cc1OC CHEMBL242725 Log Ki 26.92 nM
COc1ccccc1N1CCN(CC2COC3(CCN(C(=O)C4CCCN4)CC3)O2)CC1 CHEMBL3342863 pKi 26.92 nM
CC(C)Oc1ccccc1N1CCN([C@H]2CC[C@H](NS(=O)(=O)c3ccccc3[N+](=O)[O-])CC2)CC1 CHEMBL232593 Ki 27.0 nM
COc1ccccc1N1CCN(CCN(C(=O)C23C4C5C2C2C3C4C52CF)c2ccccn2)CC1 CHEMBL1910139 Ki 27.0 nM
CCN(CC)c1ccc2cc(-n3cc(CN4CCN(c5nc(N)c6cc(OC)c(OC)cc6n5)CC4)nn3)c(=O)oc2c1 CHEMBL3582272 Ki 27.5 nM
COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCN(c3ccccc3[N+](=O)[O-])C[C@H]2C)C1c1ccc(F)c(F)c1 CHEMBL341849 Ki 28.0 nM
CC(C)Oc1ccccc1N1CCN(CC(O)CNC(=O)c2ccc3c(c2)C(=O)N(c2ccc(O)cc2)C3=O)CC1 CHEMBL68604 Ki 28.0 nM
COc1ccccc1N1CCN(CC2COC3(CCN(C(=O)c4ccco4)CC3)O2)CC1 CHEMBL3342861 pKi 28.18 nM
COc1cc2nc(N3CCC[C@H](N)C3)nc(N)c2cc1OC CHEMBL4163810 pKi 28.18 nM
Nc1nccc(-c2ccccc2NCC2=NCCN2)n1 CHEMBL156893 Log EC50 28.84 nM
COc1cccc(-c2ccccc2)c1OCCNC[C@@H]1COc2ccccc2O1 CHEMBL214952 Log Ki 28.84 nM
c1ccc(OCCNC[C@@H]2CO[C@H](C(c3ccccc3)c3ccccc3)O2)cc1 CHEMBL4462768 pKi 29.51 nM
COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCN(c3ccccc3C(=O)OC)CC2)C1c1ccc(F)c(F)c1 CHEMBL145338 Ki 30.0 nM
CC(C)Oc1ccccc1N1CCN([C@H]2CC[C@H](NS(=O)(=O)c3ccccc3F)CC2)CC1 CHEMBL234681 Ki 30.0 nM
N=c1c(C(N)=O)cc(Cl)cn1Cc1ccccc1 CHEMBL3797529 Ki 30.0 nM
CC(C)Oc1ccccc1N1CCN(C2CCC(N3C(=O)c4c(F)c(F)c(F)c(F)c4C3=O)CC2)CC1 CHEMBL243690 Ki 30.2 nM
c1ccc(OCCNCCC2COC(c3ccccc3)(c3ccccc3)O2)cc1 CHEMBL4520390 pKi 30.2 nM
COc1ccccc1N1CCN(CCCCCN2C(=O)CC(c3ccccc3)CC2=O)CC1 CHEMBL1796036 pKi 30.9 nM
COCC1=C(C(=O)OC)[C@H](c2ccc(F)c(F)c2)N(C(=O)N[C@@H]2CC[C@@H](N3CCC(c4ccccc4C#N)CC3)C2)C(=O)N1 CHEMBL262002 Ki 31.0 nM
COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCN(c3ccccc3OC)CC2)C1c1ccc(F)c(F)c1 CHEMBL146654 Ki 31.0 nM
COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCN(c3ccccc3O)CC2)C1c1ccc(F)c(F)c1 CHEMBL141821 Ki 31.0 nM
COc1ccc(C)cc1S(=O)(=O)N[C@H]1CC[C@H](N2CCN(c3ccccc3OC(C)C)CC2)CC1 CHEMBL233623 Ki 31.0 nM
Cc1ccc(Cl)cc1N1CCN(CCc2ccc(CN3C(=O)c4ccccc4C3=O)cc2)CC1 CHEMBL3742103 IC50 31.28 nM
COc1cc(Cl)ccc1OCCNC(C)Cc1cc(C(N)=O)c2c(ccn2CCCO)c1 CHEMBL3810401 IC50 31.6 nM
c1ccc(-c2nccs2)c(OCC2=NCCN2)c1 CHEMBL142871 Log EC50 31.62 nM
Oc1ccc2cccc(NCC3=NCCN3)c2c1 CHEMBL114669 Log EC50 31.62 nM
COc1c[nH]c(=O)n(CCCN2CCN(c3ccc(F)cc3OCC(F)(F)F)CC2)c1=O CHEMBL418112 Log Ki 31.62 nM
O=c1cc[nH]c(=O)n1CCCN1CCN(c2ccc(F)cc2OCC(F)(F)F)CC1 CHEMBL299452 Log Ki 31.62 nM
O=C1CCNC(=O)N1CCCN1CCN(c2ccc(F)cc2OCC(F)(F)F)CC1 CHEMBL59153 Log Ki 31.62 nM
COc1ccccc1OCCNC[C@@H]1COC[C@@H](c2ccccc2)O1 CHEMBL493041 pKi 31.62 nM
c1ccc(OCCNCC2CCC(c3ccccc3)(c3ccccc3)O2)cc1 CHEMBL1946778 pKi 31.62 nM
CC(CNCc1ccc(CCNC[C@H](O)c2ccc(O)c3[nH]c(=O)sc23)cc1)c1ccccc1 CHEMBL1945036 pIC50 31.62 nM
CCOc1ccccc1CNCc1cccc(CCNC[C@H](O)c2ccc(O)c3[nH]c(=O)sc23)c1 CHEMBL1945290 pIC50 31.62 nM
COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCN(c3ccccc3[N+](=O)[O-])CC2)C1c1ccc(F)c(F)c1 CHEMBL145843 Ki 32.0 nM
O=S(=O)(N[C@H]1CC[C@H](N2CCC(c3ccccc3OC3CC3)CC2)CC1)c1cc(Cl)ccc1F CHEMBL228332 Ki 32.0 nM
COc1ccccc1N1CCN(C[C@H]2CO[C@@](CN3C(=O)CCCC3=O)(c3ccccc3)O2)CC1 CHEMBL1242818 pKi 32.36 nM
COc1ccccc1OCCNCC1CSC2(CCCCC2)O1 CHEMBL3901382 pKi 32.36 nM
CC(C)=CCOc1ccc(Cl)c2c1CCN(C)CC2 CHEMBL114166 Ki 33.0 nM
CSc1c(F)cccc1NCC1=NCCN1 CHEMBL70692 Log EC50 33.88 nM
O=C1CC(c2ccccc2)CC(=O)N1CCCCN1CCN(c2ccccc2Cl)CC1 CHEMBL1796034 pKi 33.88 nM
COc1cc2nc(N3CCC[C@@H](NC4=CC(=O)c5ccccc5C4=O)C3)nc(N)c2cc1OC CHEMBL4171491 pKi 33.88 nM
COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCN(c3ccccc3[N+](=O)[O-])C[C@@H]2C)C1c1ccc(F)c(F)c1 CHEMBL145547 Ki 34.0 nM
COc1cc2nc(N3CCN(C(=O)OCc4ccccc4)[C@H](C(=O)NC(C)(C)C)C3)nc(N)c2cc1OC CHEMBL19476 Ki 34.0 nM
COc1ccc(S(=O)(=O)N[C@H]2CC[C@H](N3CCC(c4ccccc4OC4CC4)CC3)CC2)cc1OC CHEMBL228278 Ki 34.0 nM
COc1ccccc1N1CCN(CCCNc2c(C(C)=O)c(C)nn(C)c2=O)CC1 CHEMBL79161 Ki 34.45 nM
O=C1CCCN1Cc1cc(CN2CCN(c3ccccc3Oc3ccccc3)CC2)on1 CHEMBL80109 Ki 34.5 nM
COc1ccccc1OCCNCC1CSC2(CCCCC2)S1 CHEMBL3938383 pKi 34.67 nM
CC(C)Oc1ccccc1N1CCN([C@H]2CC[C@H](NS(=O)(=O)c3cccc(C(F)(F)F)c3)CC2)CC1 CHEMBL233416 Ki 35.0 nM
[2H]c1c([2H])c([2H])c([C@@H]2C[C@@H](N3CCNC(C)(C)C3)c3cc(Cl)ccc32)c([2H])c1[2H] CHEMBL5201983 Ki 35.0 nM
O=C1c2ccccc2C(=O)N1Cc1ccc(CCN2CCN(c3ccc(Cl)cc3)CC2)cc1 CHEMBL3741483 IC50 35.16 nM
CC(C)c1ccc(N2CCN(CCn3c(=O)[nH]c4c([nH]c5ccccc54)c3=O)CC2)cc1 CHEMBL100434 pKi 35.48 nM
COc1ccccc1N1CCN(CC2COC3(CCN(C(=O)NC(C)(C)C)CC3)O2)CC1 CHEMBL3342876 pKi 35.48 nM
Cc1ccc(C(C(=O)NCCCN2CCN(c3ccccc3C)CC2)c2ccc(C)cc2)cc1 CHEMBL415887 Ki 36.0 nM
COc1ccc(Cl)cc1S(=O)(=O)N[C@H]1CC[C@H](N2CCC(c3ccccc3OCC(F)(F)F)CC2)CC1 CHEMBL390192 Ki 36.0 nM
CC(C)Oc1ccccc1N1CCN([C@H]2CC[C@H](NS(=O)(=O)c3ccc(F)cc3)CC2)CC1 CHEMBL428197 Ki 36.0 nM
O=C1c2ccccc2C(=O)N1Cc1ccc(CCN2CCN(c3ccccc3Cl)CC2)cc1 CHEMBL3742198 IC50 36.62 nM
Cc1ccc(N2C(=O)c3ccc(C(=O)NCCCN4CCN(c5ccccc5OC(C)C)CC4)cc3C2=O)cc1 CHEMBL304132 Ki 37.0 nM
COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCN(c3cccc(Cl)c3)CC2)C1c1ccc(F)c(F)c1 CHEMBL145443 Ki 37.0 nM
c1ccc2c(C3CCN(CCCCCN4CCCCC4)CC3)c[nH]c2c1 CHEMBL537651 Ki 37.0 nM
COc1ccccc1N1CCN(CC2COC3(CCNCC3)O2)CC1 CHEMBL3342856 pKi 37.15 nM
COc1cc2nc(N3CCC[C@@H](NC(=O)c4ccco4)C3)nc(N)c2cc1OC CHEMBL4171710 pKi 37.15 nM
Cc1ccccc1OCCNC(C)Cc1cc2c(c(C(N)=O)c1)N(CCCO)CC2 CHEMBL3808878 IC50 37.4 nM
CC(C)Oc1ccccc1N1CCN(CC(O)CNC(=O)c2ccc3c(c2)C(=O)N(c2ccc([N+](=O)[O-])cc2)C3=O)CC1 CHEMBL68746 Ki 38.0 nM
COc1ccc(Br)cc1S(=O)(=O)N[C@H]1CC[C@H](N2CCN(c3ccccc3OC(C)C)CC2)CC1 CHEMBL429076 Ki 38.0 nM
COc1ccc2c(c1)S(=O)(=O)CCC2NCCOc1cc(F)ccc1F CHEMBL4214419 Ki 38.0 nM
COc1ccc(Cl)cc1N1CCN(CCCCN2C(=O)CC(c3ccccc3)CC2=O)CC1 CHEMBL1796035 pKi 38.9 nM
COc1ccccc1N1CCN(CC2CSC3(CCCCC3)O2)CC1 CHEMBL3892434 pKi 38.9 nM
COCC1=C(C(=O)OC)[C@H](c2ccc(F)c(F)c2)N(C(=O)N[C@H]2CC[C@@H](N3CCN(c4ccccc4C#N)CC3)C2)C(=O)N1 CHEMBL300821 Ki 39.0 nM
COC(c1c[nH]cn1)c1sccc1Br CHEMBL1744266 Ki 39.0 nM
N=c1c(C(N)=O)cc(Cl)cn1Cc1ccccc1Cl CHEMBL3799219 Ki 39.0 nM
CC(C)Oc1ccccc1N1CCN(Cc2nc(CN3CCCCC3=O)cs2)CC1 CHEMBL310890 Ki 39.5 nM
COc1ccccc1N1CCN(C[C@H]2CO[C@@](CN3C(=O)CCC3=O)(c3ccccc3)O2)CC1 CHEMBL1242724 pKi 39.81 nM
O=c1[nH]c2c(O)ccc([C@@H](O)CNCCCc3cccc(CNCCc4c(Cl)cccc4Cl)c3)c2s1 CHEMBL1945296 pIC50 39.81 nM
CC(Cc1cccc(CNCCc2c(Cl)cccc2Cl)c1)NC[C@H](O)c1ccc(O)c2[nH]c(=O)sc12 CHEMBL1945297 pIC50 39.81 nM
COc1ccccc1N1CCN(CC2COC3(CCN(C(=O)C4CCCCC4)CC3)O2)CC1 CHEMBL3342862 pKi 39.81 nM
CC(C)Oc1ccccc1N1CCN(CC(O)CNC(=O)c2ccc3c(c2)C(=O)N(c2ccc(N(C)C)cc2)C3=O)CC1 CHEMBL67648 Ki 40.0 nM
COc1ccc(S(=O)(=O)N[C@H]2CC[C@H](N3CCC(c4ccccc4OC(C)C)CC3)CC2)cc1OC CHEMBL388361 Ki 40.0 nM
CCCCC1CCN(CCCC(=O)c2ccccc2C)CC1 CHEMBL1242950 Ki 40.0 nM
O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCC(n2c(=O)oc3ccccc32)CC1 CHEMBL311890 Ki 41.0 nM
CC(C)Oc1ccccc1N1CCN(CC(O)CNC(=O)c2ccc3c(c2)C(=O)N(c2cccc(Cl)c2)C3=O)CC1 CHEMBL71580 Ki 41.0 nM
O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1 CHEMBL1108 Ki 41.0 nM
O=C(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1 CHEMBL54 Ki 41.0 nM
CN1CCN2c3ccccc3Cc3ccccc3C2C1 CHEMBL6437 Ki 41.0 nM
c1ccc(-c2ccccc2NCC2=NCCN2)nc1 CHEMBL154298 Log EC50 41.69 nM
CC[C@@H]1CN2CCc3c([nH]c4ccccc34)[C@@H]2C[C@@H]1/C(=C\OC)C(=O)OC CHEMBL60533 Ki 41.7 nM
CO/N=C/c1ccccc1NCC1=NCCN1 CHEMBL351542 Log IC50 42.66 nM
COc1ccccc1N1CCN(CC2COC3(CC[S+]([O-])CC3)O2)CC1 CHEMBL3342854 pKi 42.66 nM
CSc1ccc(C(F)(F)F)cc1NCC1=NCCN1 CHEMBL72724 Log EC50 43.65 nM
COc1ccccc1OCCNC[C@@H]1COC[C@H](c2ccccc2)O1 CHEMBL452437 pKi 43.65 nM
O=C1CC(c2ccccc2)CC(=O)N1CCCN1CCN(c2ccccc2Cl)CC1 CHEMBL1796031 pKi 43.65 nM
CC(C)Oc1ccccc1N1CCN(Cc2cc(CN3CCCCC3=O)nn2C)CC1 CHEMBL76867 Ki 44.0 nM
O=S(=O)(N[C@H]1CC[C@H](N2CCC(c3ccccc3OCC(F)(F)F)CC2)CC1)c1cc(Cl)ccc1F CHEMBL228494 Ki 44.0 nM
O=S(=O)(N[C@H]1CC[C@@H](N2CCN(c3ccccc3OCC3CC3)CC2)CC1)c1cc(Cl)ccc1F CHEMBL234476 Ki 44.0 nM
Cc1cc2c(s1)Nc1ccccc1N=C2N1CCN(C)CC1 CHEMBL715 Ki 45.0 nM
COc1ccccc1N1CCN(CCCN2C(=O)CC(c3ccccc3)CC2=O)CC1 CHEMBL1796030 pKi 45.71 nM
O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(c2ncccn2)CC1 CHEMBL8412 Ki 46.0 nM
CC(C)Oc1ccccc1N1CCN([C@H]2CC[C@@H](NS(=O)(=O)c3cccnc3)CC2)CC1 CHEMBL234854 Ki 46.0 nM
CN1CCc2cc3c(c4c2[C@H]1Cc1ccccc1-4)OCO3 CHEMBL483825 Kb 46.0 nM
CC(C)Oc1ccccc1N1CCN(Cc2cc(CN3CCCCCC3=O)cs2)CC1 CHEMBL421297 Ki 47.0 nM
COc1ccc(Cl)cc1S(=O)(=O)N[C@H]1CC[C@H](N2CCC(c3ccccc3OC3CC3)CC2)CC1 CHEMBL228279 Ki 47.0 nM
OCCOCCN1CCN(C2=Nc3ccccc3Sc3ccccc32)CC1 CHEMBL716 Ki 47.5 nM
COc1ccc(Cl)cc1S(=O)(=O)N[C@H]1CC[C@@H](N2CCN(c3ccccc3OCC3CC3)CC2)CC1 CHEMBL234474 Ki 48.0 nM
Cc1ccsc1-c1ccccc1NCC1=NCCN1 CHEMBL152693 Log EC50 48.98 nM
COc1cc2nc(N3CCC[C@H](NC(=O)[C@H]4COc5ccccc5O4)C3)nc(N)c2cc1OC CHEMBL4170675 pKi 48.98 nM
COc1ccc(S(=O)(=O)N[C@H]2CC[C@H](N3CCC(c4ccccc4OCCF)CC3)CC2)cc1OC CHEMBL228606 Ki 49.0 nM
COc1cc(F)ccc1OCCNC(C)Cc1cc2c(c(C(N)=O)c1)N(CCCO)CC2 CHEMBL3809600 IC50 49.6 nM
Cc1ccc(N(NC2=NCCN2)c2cccc(O)c2)cc1 CHEMBL194849 Ki 49.7 nM
Cc1cc(=O)n(CCCN2CCN(c3ccc(F)cc3OCC(F)(F)F)CC2)c(=O)[nH]1 CHEMBL56489 Log Ki 50.12 nM
COc1ccccc1CCCNCC1COC(c2ccccc2)(c2ccccc2)O1 CHEMBL1088072 pKi 50.12 nM
O=c1[nH]c2c(O)ccc([C@@H](O)CNCCc3cccc(CNCCc4ccccc4Cl)c3)c2s1 CHEMBL1944690 pIC50 50.12 nM
O=c1[nH]c2c(O)ccc([C@@H](O)CNCCc3ccc(CNCCc4ccccc4F)cc3)c2s1 CHEMBL1944692 pIC50 50.12 nM
COc1ccc(N2C(=O)c3ccc(C(=O)NCC(O)CN4CCN(c5ccccc5OC(C)C)CC4)cc3C2=O)cc1 CHEMBL302940 Ki 51.0 nM
CC(C)Oc1ccccc1N1CCN(CC(O)CNC(=O)c2ccc3c(c2)C(=O)N(c2ccc(Cl)c(Cl)c2)C3=O)CC1 CHEMBL302092 Ki 51.0 nM
CCSc1ccccc1NCC1=NCCN1 CHEMBL540035 Log EC50 51.29 nM
COc1ccccc1N1CCN(CCCN2C(=O)CC(C)(c3ccccc3)CC2=O)CC1 CHEMBL1796044 pKi 51.29 nM
COc1ccccc1N1CCN(CC2COC3(CCS(=O)(=O)CC3)O2)CC1 CHEMBL3342855 pKi 51.29 nM
CC(C)Oc1ccccc1N1CCN(Cc2cc(CN3CCCCC3=O)n(C)n2)CC1 CHEMBL440499 Ki 52.0 nM
COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCN(c3ccc(Cl)cc3)CC2)C1c1ccc(F)c(F)c1 CHEMBL142307 Ki 52.0 nM
COc1ccc(N2C(=O)c3ccc(C(=O)NC[C@@H](O)CN4CCN(c5ccccc5OC(C)C)CC4)cc3C2=O)cc1 CHEMBL302942 Ki 52.0 nM
CC(C)Oc1ccccc1N1CCN(C[C@@H](O)CNC(=O)c2ccc3c(c2)C(=O)N(c2ccc(N(C)C)cc2)C3=O)CC1 CHEMBL309106 Ki 52.0 nM
CN(C)CCC=C1c2ccccc2CCc2ccccc21 CHEMBL629 Ki 52.0 nM
CS(=O)(=O)c1cccc(Cn2cc(Cl)cc(C(N)=O)c2=N)c1 CHEMBL3799783 Ki 52.0 nM
O=C1CC2(CCN(CCc3cccc4ccccc34)CC2)Oc2ccc(NS(=O)(=O)Cc3ccccc3)cc21 CHEMBL322688 Ki 53.0 nM
COc1ccc(S(=O)(=O)N[C@H]2CC[C@H](N3CCC(c4cc(F)ccc4OC(C)C)CC3)CC2)cc1OC CHEMBL390473 Ki 53.0 nM
CN1CCC(=C2c3ccccc3C=Cc3ccccc32)CC1 CHEMBL516 Ki 53.0 nM
COc1ccc(-c2ccccc2)cc1OCCNC[C@@H]1COc2ccccc2O1 CHEMBL214552 Log Ki 53.7 nM
COc1ccccc1N1CCN(CCCCN2C(=O)CC(c3ccc([N+](=O)[O-])cc3)CC2=O)CC1 CHEMBL1796043 pKi 53.7 nM
COc1ccccc1N1CCN(C[C@H]2OCCO[C@@H]2c2ccccc2)CC1 CHEMBL4451283 pKi 53.7 nM
Cc1ccc(N2C(=O)c3ccc(C(=O)NC[C@H](O)CN4CCN(c5ccccc5OC(C)C)CC4)cc3C2=O)cc1 CHEMBL431362 Ki 54.0 nM
N=c1c(C(N)=O)cc(Cl)cn1CCCc1ccccc1 CHEMBL3799155 Ki 54.0 nM
CC(C)Oc1ccccc1N1CCN(CC(O)CNC(=O)c2ccc3c(c2)C(=O)N(c2ccc(Cl)cc2)C3=O)CC1 CHEMBL68601 Ki 55.0 nM
CC(C)Oc1ccccc1N1CCN([C@H]2CC[C@H](NS(=O)(=O)c3ccccc3)CC2)CC1 CHEMBL234669 Ki 55.0 nM
COc1ccc(N2C(=O)c3ccc(C(=O)NCC(O)CN4CCN(c5ccccc5OC(C)C)CC4)cc3C2=O)cc1OC CHEMBL70095 Ki 56.0 nM
COc1ccc(OC)c(S(=O)(=O)N[C@H]2CC[C@H](N3CCN(c4ccccc4OC(C)C)CC3)CC2)c1 CHEMBL234194 Ki 56.0 nM
CC(CCc1ccc(O)cc1)NCCc1ccc(O)c(O)c1 CHEMBL926 Ki 56.0 nM
COc1cccc(OC)c1OCCNC[C@@H]1COCC(c2ccccc2)(c2ccccc2)O1 CHEMBL493697 pKi 56.23 nM
O=S(=O)(N[C@H]1CC[C@H](N2CCC(c3ccccc3OC3CC3)CC2)CC1)c1ccc2c(c1)OCO2 CHEMBL228333 Ki 57.0 nM
COc1cccc(OCCNCC2COC(c3ccccc3)(c3ccccc3)O2)c1 CHEMBL1077168 pKi 57.54 nM
OCC(CNCCOc1ccccc1)OC(c1ccccc1)c1ccccc1 CHEMBL4558985 pKi 57.54 nM
CN(C)CCC=C1c2ccccc2COc2ccccc21 CHEMBL1628227 Ki 58.0 nM
CN1C2CCC1CC(OC(c1ccc(F)cc1)c1ccc(F)cc1)C2 CHEMBL543113 Ki 58.21 nM
CSc1ccc2c(c1)C(=O)N(CCCCN1CCC(n3c(=O)oc4ccccc43)CC1)S2(=O)=O CHEMBL309518 Ki 59.0 nM
O=C1OC2(CCN(CCc3cccc4ccccc34)CC2)Cc2ccccc21 CHEMBL98168 Ki 60.0 nM
COc1ccc(S(=O)(=O)N[C@H]2CC[C@H](N3CCC(c4ccc(F)cc4OC(C)C)CC3)CC2)cc1OC CHEMBL228658 Ki 60.0 nM
CCC(C)c1ccc(N2CCN(CCn3c(=O)[nH]c4c([nH]c5ccccc54)c3=O)CC2)cc1 CHEMBL95191 pKi 60.26 nM
COc1cc(C)ccc1OCCNC(C)Cc1cc2c(c(C(N)=O)c1)N(CCCO)CC2 CHEMBL3810220 IC50 60.6 nM
Cc1ccc(N2C(=O)c3ccc(C(=O)NCC(O)CN4CCN(c5ccccc5OC(C)C)CC4)cc3C2=O)cc1 CHEMBL69295 Ki 62.0 nM
N#Cc1cc(F)ccc1C1CCN(CCCNC(=O)C2=CNC(=O)N[C@@H]2c2ccc(F)c(F)c2)CC1 CHEMBL94188 Ki 62.0 nM
CNc1ccc2c(c1)[C@H](NCCOc1cc(F)ccc1F)CCS2(=O)=O CHEMBL4210954 Ki 62.0 nM
Cn1c(=O)cnn(CCCCN2CCN(c3ccccc3OCCF)CC2)c1=O CHEMBL2413153 Ki 62.6 nM
CC(C)Oc1ccccc1N1CCN(C[C@H](O)CNC(=O)c2ccc3c(c2)C(=O)N(c2cccc(F)c2)C3=O)CC1 CHEMBL71473 Ki 63.0 nM
CCOC(=O)c1ccccc1NCC1=NCCN1 CHEMBL329928 Log EC50 63.1 nM
Cn1ncnc1-c1ccccc1NCC1=NCCN1 CHEMBL18069 Log EC50 63.1 nM
Cc1c[nH]c(=O)n(CCCN2CCN(c3ccc(F)cc3OCC(F)(F)F)CC2)c1=O CHEMBL24777 Log Ki 63.1 nM
O=c1[nH]cc(CO)c(=O)n1CCCN1CCN(c2ccc(F)cc2OCC(F)(F)F)CC1 CHEMBL55645 Log Ki 63.1 nM
O=C1CC(c2ccc(Cl)cc2)CC(=O)N1CCCN1CCN(c2ccccc2Cl)CC1 CHEMBL1796040 pKi 63.1 nM
O=c1[nH]c2c(O)ccc([C@@H](O)CNCCc3cccc(CNCCc4c(Cl)cccc4Cl)c3)c2s1 CHEMBL1947157 pIC50 63.1 nM
N#Cc1ccc(N2CCN(CCc3ccc(CN4C(=O)c5ccccc5C4=O)cc3)CC2)cc1 CHEMBL3741260 IC50 63.54 nM
COc1ccc(S(=O)(=O)N[C@H]2CC[C@@H](N3CCN(c4ccccc4OCC4CC4)CC3)CC2)cc1OC CHEMBL233584 Ki 64.0 nM
COC(=O)C1=C(C)N=C(C)N(CCCCCN2CCN(c3ccccc3OC)CC2)C1c1ccc(F)c(F)c1 CHEMBL145587 Ki 65.0 nM
CC(C)Oc1ccccc1N1CCN(CC(O)CNC(=O)c2ccc3c(c2)C(=O)N(c2ccccc2)C3=O)CC1 CHEMBL69143 Ki 65.0 nM
N=c1c(C(N)=O)cc(Cl)cn1Cc1ccc(C(N)=O)c(Cl)c1 CHEMBL3798527 Ki 65.0 nM
Fc1ccc(Cl)c(OCCNCc2cccc(Cl)c2)c1 CHEMBL4218360 Ki 65.0 nM
CC(C)Oc1ccccc1N1CCN(Cc2cc(CN3CCCC3=O)no2)CC1 CHEMBL309969 Ki 65.5 nM
COc1ccc(F)cc1S(=O)(=O)N[C@H]1CC[C@H](N2CCN(c3ccccc3OC(C)C)CC2)CC1 CHEMBL392066 Ki 66.0 nM
COC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 CHEMBL5483012 Log Ki 66.07 nM
CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 CHEMBL91022 Log Ki 66.07 nM
COc1cccc(OC)c1OCCNCC1COCC(c2ccccc2)(c2ccccc2)O1 CHEMBL2312225 pKi 66.07 nM
O=C1CC2(CCN(CCc3cccc4ccccc34)CC2)Oc2ccccc21 CHEMBL101869 Ki 67.0 nM
CN1C[C@H](CNC(=O)OCc2ccccc2)C[C@@H]2c3cccc4c3c(cn4C)C[C@H]21 CHEMBL19215 Ki 67.0 nM
CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1 CHEMBL395110 Ki 67.0 nM
COc1ccccc1N1CCN(CCCN2C(=O)CC(c3ccc([N+](=O)[O-])cc3)CC2=O)CC1 CHEMBL1796042 pKi 67.61 nM
COc1ccccc1N1CCN(C[C@H]2CCC(c3ccccc3)(c3ccccc3)[C@H]2O)CC1 CHEMBL1946787 pKi 67.61 nM
COc1ccccc1N1CCN(C[C@H]2CCC(c3ccccc3)(c3ccccc3)[C@@H]2O)CC1 CHEMBL1946788 pKi 67.61 nM
O=C1NC=C(C(=O)NCCCN2CCC(c3ccc(F)cc3)CC2)[C@@H](c2ccc(F)c(F)c2)N1 CHEMBL94167 Ki 68.0 nM
CN1C=C(C(=O)NCCCN2CCC(c3ccc(F)cc3C#N)CC2)[C@@H](c2ccc(F)c(F)c2)NC1=O CHEMBL90086 Ki 69.0 nM
c1ccc2c(C3CCN(CCCN4CCCCC4)CC3)c[nH]c2c1 CHEMBL537428 Ki 69.0 nM
COc1ccccc1N1CCN(CCCN2C(=O)CC(c3ccc(Cl)cc3)CC2=O)CC1 CHEMBL1796039 pKi 69.18 nM
COc1ccccc1OCCNCC1(c2ccccc2)COCCO1 CHEMBL4471113 pKi 69.18 nM
O=S(=O)(N[C@H]1CC[C@H](N2CCC(c3ccccc3OCC(F)(F)F)CC2)CC1)c1cccc(OC(F)F)c1 CHEMBL228553 Ki 70.0 nM
O=C1c2cc(F)ccc2S(=O)(=O)N1CCCCN1CCC(n2c(=O)oc3ccccc32)CC1 CHEMBL83592 Ki 71.0 nM
CN1CCc2c(Cl)ccc3oc(Br)c(c23)C1 CHEMBL123138 Ki 72.0 nM
COc1ccccc1N1C(=O)c2ccc(C(=O)NCC(O)CN3CCN(c4ccccc4OC(C)C)CC3)cc2C1=O CHEMBL68565 Ki 72.0 nM
c1ccc(OCCNC[C@@H]2COC[C@H](c3ccccc3)O2)cc1 CHEMBL492835 pKi 72.44 nM
COc1ccccc1N1CCN(CCCCN2C(=O)CC(c3ccc(Cl)cc3)CC2=O)CC1 CHEMBL1796041 pKi 72.44 nM
Cc1ccc2c(c1)C(=O)N(CCCCN1CCC(n3c(=O)oc4ccccc43)CC1)S2(=O)=O CHEMBL81006 Ki 73.0 nM
Cc1cccc(N2C(=O)c3ccc(C(=O)NCC(O)CN4CCN(c5ccccc5OC(C)C)CC4)cc3C2=O)c1 CHEMBL303248 Ki 73.0 nM
COc1cc2nc(N3CCN(C(=O)c4ccco4)[C@H](C(=O)NC(C)(C)C)C3)nc(N)c2cc1OC CHEMBL19826 Ki 73.0 nM
COc1ccccc1N1CCN(CCN(C(=O)C23CCC(CF)(CC2)CC3)c2ccccn2)CC1 CHEMBL1910140 Ki 73.0 nM
O=C1c2ccc([N+](=O)[O-])cc2S(=O)(=O)N1CCCCN1CCC(n2c(=O)oc3ccccc32)CC1 CHEMBL82877 Ki 75.0 nM
CC(C)Oc1ccccc1N1CCN(CC(O)CNC(=O)c2ccc3c(c2)C(=O)N(c2cccc(F)c2)C3=O)CC1 CHEMBL302246 Ki 75.0 nM
CC(C)Oc1ccccc1N1CCN(CC(O)CNC(=O)c2ccc3c(c2)C(=O)N(c2ccc(C(C)(C)C)cc2)C3=O)CC1 CHEMBL68699 Ki 75.0 nM
COc1ccccc1N1CCN(CCCN2C(=O)CC3(CCc4ccccc43)CC2=O)CC1 CHEMBL1796049 pKi 75.86 nM
c1ccc(OCCNCC[C@@H]2CO[C@H](C(c3ccccc3)c3ccccc3)O2)cc1 CHEMBL4473623 pKi 75.86 nM
COc1ccc2c(c1)C(=O)N(CCCCN1CCC(n3c(=O)oc4ccccc43)CC1)S2(=O)=O CHEMBL83340 Ki 76.0 nM
COc1ccncc1S(=O)(=O)N[C@H]1CC[C@H](N2CCN(c3ccccc3OC(C)C)CC2)CC1 CHEMBL391017 Ki 76.0 nM
O=c1ccc2ccc(OCCCCN3CCN(c4cccc5sccc45)CC3)cc2[nH]1 CHEMBL2105760 Ki 76.44 nM
COc1ccc(Cl)cc1N1CCN(CCCCN2C(=O)CC(C)(c3ccccc3)CC2=O)CC1 CHEMBL1796047 pKi 77.62 nM
Oc1ccccc1OCCNCC1COCC(c2ccccc2)(c2ccccc2)O1 CHEMBL4082195 pKi 77.62 nM
COC(=O)C1=C(C)N=C(C)N(CCCCCN2CCN(c3ccccc3C(=O)OC)CC2)C1c1ccc(F)c(F)c1 CHEMBL436407 Ki 79.0 nM
CCNC(=O)c1ccccc1NCC1=NCCN1 CHEMBL99362 Log EC50 79.43 nM
COC(=O)C1=C(C)NC(C)=C(C(=O)OCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)[C@@H]1c1cccc([N+](=O)[O-])c1 CHEMBL2051956 Log Ki 79.43 nM
CCCNC(=O)c1ccccc1NCc1c[nH]cn1 CHEMBL325745 Log EC50 79.43 nM
O=c1[nH]c2c(O)ccc([C@@H](O)CNCCc3ccc(CNCCc4c(Cl)cccc4Cl)cc3)c2s1 CHEMBL1944689 pIC50 79.43 nM
COc1ccccc1CCNCc1cccc(CCNC[C@H](O)c2ccc(O)c3[nH]c(=O)sc23)c1 CHEMBL1944693 pIC50 79.43 nM
O=c1[nH]c2c(O)ccc([C@@H](O)CNCCc3cccc(CNCc4ccccc4F)c3)c2s1 CHEMBL1945042 pIC50 79.43 nM
COc1ccccc1CNCc1ccc(CCNC[C@@H](O)c2ccc(O)c3[nH]c(=O)sc23)cc1 CHEMBL1945504 pIC50 79.43 nM
COc1cccc(OC)c1OCCNC[C@H]1COc2c(OC)cccc2O1 CHEMBL2153559 pKi 79.43 nM
COCOc1ccccc1OCCNCC1COCC(c2ccccc2)(c2ccccc2)O1 CHEMBL4071929 pKi 79.43 nM
COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 CHEMBL142383 Ki 80.0 nM
CC(C)Oc1ccccc1N1CCN(CCCNC(=O)CN2CCCCC2=O)CC1 CHEMBL12062 Ki 80.0 nM
c1cnc(-c2ccccc2NCC2=NCCN2)nc1 CHEMBL156661 Log EC50 81.28 nM
c1ccc(OCCNC[C@H]2COCC(c3ccccc3)(c3ccccc3)O2)cc1 CHEMBL2312538 pKi 83.18 nM
COc1ccc2c(c1OCCNC[C@@H]1COc3ccccc3O1)NCC2 CHEMBL3217244 pKi 83.18 nM
COc1cccc2c(CCCNCCOc3ccccn3)cccc12 CHEMBL138109 Ki 83.24 nM
O=C1c2cc(Cl)ccc2S(=O)(=O)N1CCCCN1CCC(n2c(=O)oc3ccccc32)CC1 CHEMBL313990 Ki 85.0 nM
COc1ccc(S(=O)(=O)N[C@H]2CC[C@H](N3CCC(c4ccccc4OCC(F)F)CC3)CC2)cc1OC CHEMBL228607 Ki 86.0 nM
O=S(=O)(N[C@H]1CC[C@H](N2CCC(c3ccccc3OCC(F)(F)F)CC2)CC1)c1ccc(OC(F)F)cc1 CHEMBL228554 Ki 86.0 nM
NC(=O)c1ccc2c(c1)C(NCCOc1cc(F)ccc1F)CCS2(=O)=O CHEMBL4210948 Ki 86.0 nM
CCC1=C(C(=O)OC)C(c2ccc([N+](=O)[O-])cc2)N(C(=O)NCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C(=O)N1 CHEMBL123012 Ki 87.0 nM
CC(C)Oc1ccccc1C1CCN([C@H]2CC[C@H](NS(=O)(=O)c3ccc(F)c(F)c3)CC2)CC1 CHEMBL229084 Ki 87.0 nM
c1ccc(OCCNC[C@H]2CO[C@H](C(c3ccccc3)c3ccccc3)O2)cc1 CHEMBL4457585 pKi 87.1 nM
CN(C)CCCN1c2ccccc2CCc2ccc(Cl)cc21 CHEMBL415 Ki 88.0 nM
COc1ccccc1N1CCN(CC2COC3(CCN(C(C)=O)CC3)O2)CC1 CHEMBL3342864 pKi 89.13 nM
COc1ccccc1N1CCN(C[C@H]2OCCOC2(c2ccccc2)c2ccccc2)CC1 CHEMBL4441888 pKi 89.13 nM
CC(CN1c2ccccc2Sc2ccccc21)N(C)C CHEMBL643 Ki 90.0 nM
CCOC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1 CHEMBL142957 Ki 91.0 nM
CCC1=C(C(=O)OC)C(c2ccc(F)cc2F)N(C(=O)NCCCN2CCN(c3ccccc3C(N)=O)CC2)C(=O)N1 CHEMBL445577 Ki 91.0 nM
O=C1CCc2ccccc2N1CCCN1CCN(c2ccccc2)CC1 CHEMBL4085780 pKi 91.2 nM
C[C@H]1OC(=O)N(C(=O)NCCCN2CCC(c3ccc(F)cc3)CC2)[C@H]1c1ccc(F)c(F)c1 CHEMBL2114249 Ki 92.0 nM
COc1ccccc1N1CCN(Cc2ccc(Br)s2)CC1 CHEMBL67932 Ki 92.0 nM
CC(C)Oc1ccccc1N1CCN(Cc2cc(CN3CCCCC3=O)cs2)CC1 CHEMBL67713 Ki 92.0 nM
CN1CCc2cc3c(c4c2[C@@H]1Cc1ccccc1-4)OCO3 CHEMBL2365576 Kb 92.2 nM
COC(=O)C1=C(C)NC(=O)N(C(=O)NCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C1c1ccc2nonc2c1 CHEMBL142743 Ki 93.0 nM
COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCOc2ccc(F)cc2)CC1OC CHEMBL1729 Ki 93.0 nM
O[C@@H]1[C@@H](CNCCOc2ccccc2)CCC1(c1ccccc1)c1ccccc1 CHEMBL1946785 pKi 93.33 nM
COc1ccccc1CCN1CCC2(CC1)CC(=O)c1ccc(NS(C)(=O)=O)cc1O2 CHEMBL431631 Ki 94.0 nM
CC(Cc1cc(C(N)=O)c2c(ccn2CCCO)c1)NCCOc1cc(Cl)ccc1OCC(F)(F)F CHEMBL3810145 IC50 94.0 nM
COCC1=C(C(=O)OC)[C@H](c2ccc(F)c(F)c2)N(C(=O)N[C@H]2CC[C@H](N3CCC(C#N)(c4ccccc4)CC3)C2)C(=O)N1 CHEMBL301024 Ki 95.0 nM
COc1ccccc1OCCNCC1COC2(CCCCC2)O1 CHEMBL3981480 pKi 95.5 nM
c1ccc(OCCNCC[C@H]2CO[C@H](C(c3ccccc3)c3ccccc3)O2)cc1 CHEMBL4580335 pKi 95.5 nM
COc1ccccc1OCCNC[C@H]1OCCO[C@@H]1c1ccccc1 CHEMBL4452933 pKi 95.5 nM
COCC1=C(C(=O)OC)[C@H](c2ccc(F)c(F)c2)N(C(=O)N[C@H]2CC[C@@H](N3CCC(c4ccccc4C#N)CC3)C2)C(=O)N1 CHEMBL292365 Ki 97.0 nM
COc1ccccc1OCCNC[C@@H]1CO[C@@H](c2ccccc2)CO1 CHEMBL494908 pKi 97.72 nM
COc1ccc(Cl)cc1N1CCN(CCCN2C(=O)CC(C)(c3ccccc3)CC2=O)CC1 CHEMBL1796045 pKi 97.72 nM
COc1ccccc1N1CCN(CCN(C(=O)C23C4C5C2C2C3C4C52I)c2ccccn2)CC1 CHEMBL1774991 Ki 98.0 nM
c1ccc2c(c1)CCC1(CCN(CCc3cccc4ccccc34)CC1)O2 CHEMBL101739 Ki 99.0 nM