Cc1ccc(-c2nc(SCC(=O)O)c3c(=O)n(C)c(=O)n(C)c3n2)cc1 CHEMBL4579008 Kd 0.00128 nM
O=C(N[C@@H]1CNCC[C@H]1c1cccc(F)c1)c1cc2c(s1)CCCn1ncc(Cl)c1-2 CHEMBL5407182 IC50 0.02 nM
O=C(N[C@@H]1CNCC[C@H]1c1ccc(F)c(F)c1)c1cc2c(s1)OCCn1ncc(Br)c1-2 CHEMBL5406146 IC50 0.023 nM
NC[C@H](Cc1cccc(F)c1)NC(=O)c1cc(Br)c(-c2ccnc3[nH]ccc23)s1 CHEMBL523586 Ki 0.03 nM
O=C(N[C@@H]1CNCC[C@H]1c1cc(F)c(F)c(F)c1)c1ccc2c(c1)OCCn1nccc1-2 CHEMBL5414576 IC50 0.035 nM
O=C(N[C@@H]1CNCC[C@H]1c1cccc(F)c1)c1cc2c(s1)CCCn1ncc(Br)c1-2 CHEMBL5398425 IC50 0.036 nM
NCC(Cc1ccccc1)NC(=O)c1cc(Br)c(-c2ccnc3[nH]ccc23)s1 CHEMBL469590 Ki 0.04 nM
NC[C@H](Cc1ccccc1C(F)(F)F)NC(=O)c1cc(Br)c(-c2ccnc3[nH]ccc23)s1 CHEMBL520788 Ki 0.05 nM
O=C(N[C@@H]1CNCC[C@H]1c1ccc(F)c(F)c1)c1cc2c(s1)OCCn1ncc(Cl)c1-2 CHEMBL5437264 IC50 0.053 nM
O=C(N[C@@H]1CNCC[C@H]1c1cc(F)cc(F)c1)c1cc2c(s1)CCCn1ncc(Br)c1-2 CHEMBL5428430 IC50 0.054 nM
NC[C@H](Cc1ccccc1)NC(=O)c1cc(Br)c(-c2ccnc3[nH]ccc23)s1 CHEMBL470597 Ki 0.06 nM
NC[C@H](Cc1ccc(F)cc1)NC(=O)c1cc(Br)c(-c2ccnc3[nH]ccc23)s1 CHEMBL496690 Ki 0.06 nM
Cn1ncc(Cl)c1-c1cc(C(=O)N[C@H](CN)Cc2ccc(F)c(F)c2)oc1Cl CHEMBL3137336 IC50 0.066 nM
Cn1ncc(Cl)c1-c1cc(C(=O)N[C@H](CN)Cc2cccc(F)c2)sc1Cl CHEMBL2219422 Ki 0.08 nM
O=C(N[C@@H]1CNCC[C@H]1c1cc(F)c(F)c(F)c1)c1cc2c(s1)OCCn1ncc(Br)c1-2 CHEMBL5400934 IC50 0.083 nM
O=C(N[C@@H]1CNCC[C@H]1c1ccc(F)c(F)c1)c1cc2c(s1)CCCn1ncc(Br)c1-2 CHEMBL5408482 IC50 0.091 nM
NC[C@H](Cc1cccc(C(F)(F)F)c1)NC(=O)c1cc(Br)c(-c2ccnc3[nH]ccc23)s1 CHEMBL482536 Ki 0.1 nM
Cc1cc(-c2cn(CCN3CCC3)c(C3CCN(c4ncnc(N)c4Br)CC3)n2)ccc1F CHEMBL3899716 IC50 0.1 nM
O=C(N[C@@H]1CNCC[C@H]1c1cc(F)c(F)c(F)c1)c1cc2c(s1)OCCn1ncc(Cl)c1-2 CHEMBL5438374 IC50 0.12 nM
O=C(N[C@@H]1CNCC[C@H]1c1ccc(Cl)c(C(F)(F)F)c1)c1cc2c(s1)OCCn1ncc(Br)c1-2 CHEMBL5399312 IC50 0.14 nM
CC(C)c1cc(-c2cn(CCN3CCC3)c(C3CCN(c4ncnc(N)c4Br)CC3)n2)ccn1 CHEMBL3966806 IC50 0.15 nM
Cc1n[nH]c2ccc(-c3cncc(OC[C@@H](N)Cc4c[nH]c5ccccc45)c3)cc12 CHEMBL379300 Ki 0.16 nM
CC(C)(Cc1ccco1)C1C(=O)Nc2ccc(-c3cncc(OC[C@@H](N)Cc4c[nH]c5ccccc45)c3)cc21 CHEMBL210954 IC50 0.17 nM
N[C@H](COc1cncc(-c2ccc3c(c2)C(c2ccco2)C(=O)N3)c1)Cc1c[nH]c2ccccc12 CHEMBL573326 IC50 0.17 nM
CCn1c(-c2nonc2N)nc2c(C#CC(C)(C)O)nc(O[C@@H](CCN)c3ccccc3)cc21 CHEMBL1099297 Ki 0.2 nM
CCn1c(-c2nonc2N)nc2c(C#CC(C)(C)O)nc(OC[C@H](N)Cc3ccccc3)cc21 CHEMBL1098938 Ki 0.2 nM
CN(C)C(=O)C1CCN(c2cccc(-c3ccc4nc(-c5cccnc5N)n(-c5ccc(C6(N)CCC6)cc5)c4n3)c2)CC1 CHEMBL3640738 Kd 0.2 nM
CCN(CC)C(=O)C1CCN(c2cccc(-c3ccc4nc(-c5cccnc5N)n(-c5ccc(C6(N)CCC6)cc5)c4n3)c2)CC1 CHEMBL3640739 Kd 0.2 nM
Nc1ncccc1-c1nc2ccc(-c3cccc(N4CCC(C(=O)N5CCOCC5)CC4)c3)nc2n1-c1ccc(C2(N)CCC2)cc1 CHEMBL3640740 Kd 0.2 nM
CC(=O)NC1CCN(c2cccc(-c3ccc4nc(-c5cccnc5N)n(-c5ccc(C6(N)CCC6)cc5)c4n3)c2)CC1 CHEMBL3640741 Kd 0.2 nM
C=CC(=O)Nc1ccc2[nH]c(=O)n(C3CCN(Cc4ccc(-c5nc6cc[nH]c(=O)c6cc5-c5ccccc5)cc4)CC3)c2c1 CHEMBL4795065 IC50 0.2 nM
CCc1cnn2c1-c1cc(C(=O)N[C@@H]3CNCC[C@H]3c3ccc(F)c(F)c3)sc1OCC2 CHEMBL5411877 IC50 0.22 nM
CCc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C)c3)cn2CC2CN(C)C2)CC1 CHEMBL3936990 IC50 0.3 nM
O=C(N[C@@H]1CNCC[C@H]1c1cc(F)cc(F)c1)c1ccc2c(c1)OCCn1nccc1-2 CHEMBL5405650 IC50 0.3 nM
Cc1n[nH]c2cnc(-c3cncc(OC[C@@H](N)Cc4c[nH]c5ccccc45)c3)cc12 CHEMBL376569 IC50 0.34 nM
N[C@]1(c2ccc(-c3nc4ccc5nnc(C(F)F)n5c4cc3-c3ccccc3)cc2)C[C@](O)(C2CC2)C1 CHEMBL3679636 IC50 0.34 nM
NC1(Cc2ccc(Cl)cc2)CCN(c2ccnc3[nH]ccc23)CC1 CHEMBL596991 GI50 0.37 nM
C[C@]1(O)C[C@@](N)(c2ccc(-c3nc4ccc5nnc(C(F)F)n5c4cc3-c3ccccc3)cc2)C1 CHEMBL3679632 IC50 0.38 nM
CCn1c(-c2nonc2N)nc2c(C#CC(C)(C)O)nc(O[C@@H](CN)c3ccccc3)cc21 CHEMBL1099276 Ki 0.4 nM
CC(C)(C)C(=O)Nc1cccc(-c2ccc3nc(-c4cccnc4N)n(-c4ccc(C5(N)CCC5)cc4)c3n2)c1 CHEMBL3640733 Kd 0.4 nM
CCc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(Cl)c3)cn2CCN2CCCC2)CC1 CHEMBL3906990 IC50 0.4 nM
CNC(=O)C1CCN(c2cnc(C(=O)Nc3csc(-c4nncn4C4CC4)n3)cc2-n2cnc(C3CC3)c2)CC1 CHEMBL3969572 IC50 0.4 nM
CC(C)NC[C@@H](C(=O)N1CCN(c2ncnc3c2[C@H](C)CC(=O)N3)[C@H]2C[C@H]21)c1ccc(Cl)cc1 CHEMBL5169427 IC50 0.4 nM
O=C(N[C@@H]1CNCC[C@H]1c1ccc(F)c(F)c1)c1ccc2c(c1)OCCn1nccc1-2 CHEMBL5422811 IC50 0.4 nM
O=C(N[C@@H]1CNCC[C@H]1c1ccc(F)c(F)c1)c1cc2c(s1)OCCn1ncc(CCO)c1-2 CHEMBL5430096 IC50 0.42 nM
O=C(N[C@@H]1CNCC[C@H]1c1ccc(Cl)cc1)c1cc2c(s1)OCCn1ncc(Br)c1-2 CHEMBL5405389 IC50 0.45 nM
O=C(O)c1ccc2c(c1)C1C=CCC1C(C(=O)O)N2 CHEMBL244695 Kd 0.474 nM
CCc1c[nH]c2ncnc(N3CC[C@](N)(CNC(=O)c4ccc(F)cc4F)C3)c12 CHEMBL1171647 IC50 0.5 nM
CCNCCn1cc(-c2ccc(F)c(C(F)(F)F)c2)nc1C1CCN(c2ncnc(N)c2OC(C)C)CC1 CHEMBL3943127 IC50 0.52 nM
CC(=O)N(C)C1CCN(c2cccc(-c3ccc4nc(-c5cccnc5N)n(-c5ccc(C6(N)CCC6)cc5)c4n3)c2)CC1 CHEMBL4802156 IC50 0.55 nM
NC1(COCc2ccc(Cl)cc2)CCN(c2ncnc3[nH]ccc23)CC1 CHEMBL597793 IC50 0.59 nM
N[C@H](COc1cncc(-c2cc3cn[nH]c3cn2)c1)Cc1c[nH]c2ccccc12 CHEMBL226330 IC50 0.6 nM
Cc1n[nH]c2cnc(-c3cncc(OC[C@@H](N)Cc4cccc(C(F)(F)F)c4)c3)cc12 CHEMBL226898 IC50 0.6 nM
N[C@H](COc1cncc(-c2ccc3c(c2)/C(=C/c2ccc[nH]2)C(=O)N3)c1)Cc1ccccc1 CHEMBL388311 IC50 0.6 nM
CCn1c(-c2nonc2N)nc2c(C#CC(C)(C)O)ncc(OC[C@H]3CCCNC3)c21 CHEMBL494089 IC50 0.6 nM
CC(C)NC[C@@H](C(=O)N1[C@@H]2CC[C@H]1CN(c1ncnc3c1[C@H](C)OC(=O)N3)C2)c1ccc(Cl)cc1 CHEMBL5189707 IC50 0.6 nM
CC(C)NC[C@@H](C(=O)N1CCN(c2ncnc3c2[C@H](C)OC(=O)N3)[C@H]2C[C@H]21)c1ccc(Cl)cc1 CHEMBL5197007 IC50 0.6 nM
O=C(N[C@@H]1CNCC[C@H]1c1ccc(C(F)(F)F)c(Cl)c1)c1cc2c(s1)OCCn1ncc(Br)c1-2 CHEMBL5404104 IC50 0.61 nM
CC(C)NC[C@@H](C(=O)N1CCN(c2ncnc3c2[C@H](C)C[C@H]3O)CC1)c1ccc(Cl)cc1 CHEMBL2177390 Kd 0.64 nM
NC1(Cc2ccc(Cl)cc2)CCN(c2ncnc3[nH]ccc23)CC1 CHEMBL263664 IC50 0.66 nM
Cc1ccc(CC(C)(C)C2C(=O)Nc3ccc(-c4cncc(OC[C@@H](N)Cc5c[nH]c6ccccc56)c4)cc32)o1 CHEMBL426140 IC50 0.7 nM
Cc1ccc(C2C(=O)Nc3ccc(-c4cncc(OC[C@@H](N)Cc5c[nH]c6ccccc56)c4)cc32)o1 CHEMBL575631 IC50 0.7 nM
N[C@]1(c2ccc(-c3nc4ccc5nnc(C6NCNN6)n5c4cc3-c3ccccc3)cc2)C[C@](O)(C2CC2)C1 CHEMBL3679635 IC50 0.7 nM
CC(=O)OC(C)(C)C(=O)Nc1cccc(-c2ccc3nc(-c4cccnc4N)n(-c4ccc(C5(N)CCC5)cc4)c3n2)c1 CHEMBL3640734 Kd 0.7 nM
CC(C)CNCCn1cc(-c2ccc(F)c(C(F)(F)F)c2)nc1C1CCN(c2ncnc(N)c2C#N)CC1 CHEMBL3980521 IC50 0.7 nM
Cc1cc(-c2cn(CCNC3CCCC3)c(C3CCN(c4ncnc(N)c4C#N)CC3)n2)ccc1F CHEMBL3927358 IC50 0.7 nM
C[C@@H]1CC(=O)Nc2ncnc(N3CCN(C(=O)[C@H](CNC4CC4)c4ccc(Cl)cc4)[C@@H]4C[C@@H]43)c21 CHEMBL5182446 IC50 0.7 nM
NC[C@H](CC1CCCCC1)NC(=O)c1cc(Br)c(-c2ccnc3[nH]ccc23)s1 CHEMBL470598 Ki 0.79 nM
C#Cc1ncc(OC[C@@H](N)Cc2c[nH]c3ccccc23)cc1-c1ccc2cnccc2c1 CHEMBL207544 IC50 0.8 nM
CCc1ncc(OC[C@@H](N)Cc2c[nH]c3ccccc23)cc1-c1ccc2cnccc2c1 CHEMBL572908 IC50 0.8 nM
Cc1n[nH]c2ccc(-c3cc(OC[C@@H](N)Cc4c[nH]c5cc(F)ccc45)cnc3-c3ccoc3)cc12 CHEMBL607374 IC50 0.8 nM
Cc1occc1-c1ncc(OC[C@@H](N)Cc2c[nH]c3ccccc23)cc1-c1ccc2[nH]nc(C)c2c1 CHEMBL595939 IC50 0.8 nM
CC1(O)CC(N)(c2ccc(-c3nc4n(c3-c3ccccc3)COc3ccc(-c5ccn[nH]5)cc3-4)cc2)C1 CHEMBL3701762 IC50 0.8 nM
Nc1ncccc1-c1nc2ccc(-c3cccc(N4CCS(=O)(=O)CC4)c3)nc2n1-c1ccc(C2(N)CCC2)cc1 CHEMBL3640747 Kd 0.8 nM
CCOc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C)c3)cn2CCN(CC)CC)CC1 CHEMBL3986943 IC50 0.8 nM
N#Cc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C(F)(F)F)c3)cn2CCNC2CCCC2)CC1 CHEMBL3960355 IC50 0.8 nM
CC(C)(Cc1cccs1)C1C(=O)Nc2ccc(-c3cncc(OC[C@@H](N)Cc4c[nH]c5ccccc45)c3)cc21 CHEMBL209826 IC50 0.9 nM
Cc1n[nH]c2ccc(-c3cncc(OC[C@@H](N)Cc4cccc(I)c4)c3)cc12 CHEMBL229320 IC50 0.9 nM
N[C@H](COc1cncc(-c2ccc3c(c2)C(c2cccs2)C(=O)N3)c1)Cc1c[nH]c2ccccc12 CHEMBL572884 IC50 0.9 nM
Cc1cc(-c2cn(CCN(C)C)c(C3CCN(c4ncnc(N)c4C#N)CC3)n2)ccc1F CHEMBL3971598 IC50 0.9 nM
N#CC1CN(c2cnc(C(=O)Nc3csc(-c4nncn4C4CC4)n3)cc2-n2cnc(C3CC3)c2)C1 CHEMBL3975211 IC50 0.9 nM
NC(=O)c1ccc2nc(-c3ccc(C4(N)CCC4)cc3)c(-c3ccccc3)n2n1 CHEMBL4751394 IC50 0.9 nM
NC1(C(=O)NCc2ccc(Cl)cc2)CCN(c2ncnc3[nH]ccc23)CC1 CHEMBL598194 GI50 0.93 nM
Cn1ncc(Cl)c1-c1cc(C(=O)N[C@@H]2CN[C@H](CCO)C[C@H]2c2ccc(F)c(F)c2)oc1Cl CHEMBL4441825 IC50 0.98 nM
N[C@H](COc1cncc(-c2ccc3[nH]nc(Cl)c3c2)c1)Cc1c[nH]c2ccccc12 CHEMBL226148 IC50 1.0 nM
NC[C@H](Cc1ccccc1F)NC(=O)c1cc(Br)c(-c2ccnc3[nH]ccc23)s1 CHEMBL498052 IC50 1.0 nM
O=c1ccc(-c2nnc(C3CCN(Cc4ccc(-c5nc6cc[nH]c(=O)c6cc5-c5ccccc5)cc4)CC3)[nH]2)c[nH]1 CHEMBL488428 IC50 1.0 nM
Cc1n[nH]c2ccc(-c3cc(OC[C@@H](N)Cc4c[nH]c5c(F)cccc45)cnc3-c3ccoc3)cc12 CHEMBL594309 IC50 1.0 nM
Cc1n[nH]c2ccc(-c3cc(OC[C@@H](N)Cc4c[nH]c5ccc(F)cc45)cnc3-c3ccoc3)cc12 CHEMBL605528 IC50 1.0 nM
Cc1[nH]nc2ccc(-c3cc(OC[C@@H](N)Cc4c[nH]c5ccccc45)cnc3-c3ccoc3)cc12 CHEMBL593490 IC50 1.0 nM
Cc1occc1-c1ncc(OC[C@@H](N)Cc2c[nH]c3ccccc23)cc1-c1cnc2[nH]nc(C)c2n1 CHEMBL596583 IC50 1.0 nM
Cc1occc1-c1nc(N)c(OC[C@@H](N)Cc2c[nH]c3ccccc23)cc1-c1cnc2[nH]nc(C)c2c1 CHEMBL593375 IC50 1.0 nM
Cc1occc1-c1nc(N)c(OC[C@@H](N)Cc2c[nH]c3ccccc23)cc1-c1cnc2[nH]nc(C)c2n1 CHEMBL595944 IC50 1.0 nM
Cc1occc1-c1nc(N)c(OC[C@@H](N)Cc2c[nH]c3ccccc23)cc1-c1cc2c(C)n[nH]c2cn1 CHEMBL595459 IC50 1.0 nM
Cc1occc1-c1nc(N)c(OC[C@@H](N)Cc2c(Cl)[nH]c3ccccc23)cc1-c1cnc2[nH]nc(C)c2n1 CHEMBL593813 IC50 1.0 nM
Cc1occc1-c1nc(N)c(OC[C@@H](N)Cc2c(C#N)[nH]c3ccccc23)cc1-c1cnc2[nH]nc(C)c2n1 CHEMBL605410 IC50 1.0 nM
Cc1occc1-c1nc(N)c(OC[C@@H](N)Cc2c(C(N)=O)[nH]c3ccccc23)cc1-c1cnc2[nH]nc(C)c2n1 CHEMBL594072 IC50 1.0 nM
Cc1n[nH]c2ncc(-c3cc(OC[C@@H](N)Cc4c[nH]c5ccccc45)cnc3-c3ccoc3)cc12 CHEMBL596072 IC50 1.0 nM
Cc1n[nH]c2cnc(-c3cc(OC[C@@H](N)Cc4c[nH]c5ccccc45)cnc3-c3ccoc3)nc12 CHEMBL603197 IC50 1.0 nM
Cc1n[nH]c2cnc(-c3cc(OC[C@@H](N)Cc4c[nH]c5ccccc45)cnc3-c3ccoc3)cc12 CHEMBL594933 IC50 1.0 nM
Cc1c[nH]c2ncnc(N3CC[C@](N)(CNC(=O)c4ccc(F)cc4F)C3)c12 CHEMBL1170448 IC50 1.0 nM
Cc1c[nH]c2ncnc(N3CCN(C(=O)[C@H](N)Cc4ccc(Cl)cc4)CC3)c12 CHEMBL1258664 IC50 1.0 nM
N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ncnc3[nH]cc(Cl)c23)CC1 CHEMBL1258781 IC50 1.0 nM
C[C@@H]1SCc2ncnc(N3CCN(C(=O)[C@H](N)Cc4ccc(Cl)cc4)CC3)c21 CHEMBL1632373 IC50 1.0 nM
CC(C)NC[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ncnc3c2[C@H](C)SC3)CC1 CHEMBL1632384 IC50 1.0 nM
Cc1c(NCCN2CCCC2)cc(C(=O)CCC(F)(F)F)cc1N1CCN(c2ncnc3[nH]nc(Br)c23)CC1 CHEMBL2016893 IC50 1.0 nM
Cn1ncc(Cl)c1-c1cc(C(=O)N[C@H](CN)Cc2cccc(F)c2)oc1Cl CHEMBL3953878 pIC50 1.0 nM
O=C(Cc1nc(N2CCOCC2)cc(=O)[nH]1)N1CCc2c(Br)cccc21 CHEMBL3112850 IC50 1.0 nM
CC1Cc2c(Cl)cccc2N1C(=O)Cc1nc(N2CCOCC2)cc(=O)[nH]1 CHEMBL3970476 IC50 1.0 nM
CC1Cc2c(ccc(F)c2F)N1C(=O)Cc1nc(N2CCOCC2)cc(=O)[nH]1 CHEMBL3910755 IC50 1.0 nM
CC1Cc2c(ccc(F)c2Cl)N1C(=O)Cc1nc(N2CCOCC2)cc(=O)[nH]1 CHEMBL3930708 IC50 1.0 nM
CC1Cc2c(ccc(F)c2F)N1C(=S)Cc1nc(N2CCOCC2)c(F)c(=S)[nH]1 CHEMBL3900870 IC50 1.0 nM
Nc1ncnc(N2CCC(c3nc(-c4ccc(F)c(C(F)(F)F)c4)cn3CCN3CCC3)CC2)c1Cl CHEMBL3919089 IC50 1.0 nM
Nc1ncnc(N2CCC(c3nc(-c4ccc(F)c(C(F)(F)F)c4)cn3CCN3CCCC3)CC2)c1C=O CHEMBL3941283 IC50 1.0 nM
Cn1ncc(Cl)c1-c1ccc(C(=O)N[C@@H]2CNCC[C@H]2c2cccc(F)c2)s1 CHEMBL4435124 IC50 1.0 nM
COc1ccc2ccccc2c1C[C@H](N)COc1cncc(-c2ccc3[nH]nc(C)c3c2)c1 CHEMBL210403 Ki 1.1 nM
N[C@]1(CNC(=O)c2ccc(F)cc2F)CCN(c2ncnc3[nH]cc(Cl)c23)C1 CHEMBL1169623 IC50 1.1 nM
Nc1ncccc1-c1nc2ccc(-c3cccc(N4CCN(C(=O)C5CC5)CC4)c3)nc2n1-c1ccc(C2(N)CCC2)cc1 CHEMBL3640743 Kd 1.1 nM
CC(C)C(=O)N1CCN(c2cccc(-c3ccc4nc(-c5cccnc5N)n(-c5ccc(C6(N)CCC6)cc5)c4n3)c2)CC1 CHEMBL3640744 Kd 1.1 nM
O=C(Nc1csc(-c2nncn2C2CC2)n1)c1cc(-n2cnc(C3CC3)c2)c(N2CC3CC3C2)cn1 CHEMBL3922577 IC50 1.1 nM
CC(C)NC[C@@H](C(=O)N1CCN(c2ncnc3c2N(C)CC(=O)N3)CC1)c1ccc(Cl)cc1 CHEMBL5195664 IC50 1.1 nM
O=C(N[C@H]1CNCC[C@@H]1c1ccc(F)c(F)c1)c1cc2c(s1)OCCn1ncc(Br)c1-2 CHEMBL5425811 IC50 1.1 nM
CCc1n[nH]c2ccc(-c3cncc(OC[C@@H](N)Cc4c[nH]c5ccccc45)c3)cc12 CHEMBL574087 IC50 1.15 nM
CC(C)(Cc1cc[nH]c1)C1C(=O)Nc2ccc(-c3cncc(OC[C@@H](N)Cc4c[nH]c5ccccc45)c3)cc21 CHEMBL210940 IC50 1.2 nM
Cc1n[nH]c2ccc(-c3cncc(OC[C@@H](N)Cc4cc(C(F)(F)F)ccc4F)c3)cc12 CHEMBL227322 IC50 1.2 nM
Cc1n[nH]c2ccc(-c3cncc(OC[C@@H](N)Cc4cccc(C(F)(F)F)c4)c3)cc12 CHEMBL226625 IC50 1.2 nM
N[C@H](COc1cncc(-c2ccc3[nH]nc(-c4ccc[nH]4)c3c2)c1)Cc1c[nH]c2ccccc12 CHEMBL572670 IC50 1.2 nM
C[C@@H](O)CNC(=O)c1cccc(-c2ccc3nc(-c4cccnc4N)n(-c4ccc(C5(N)CCC5)cc4)c3n2)c1 CHEMBL3640737 Kd 1.2 nM
C[C@H](n1cnnc1-c1nc(NC(=O)c2cc(-n3cnc(C4CC4)c3)c(N3CCN(CC(F)(F)F)CC3)cn2)cs1)C(F)(F)F CHEMBL3902880 IC50 1.2 nM
Cn1ncc(Cl)c1-c1csc(C(=O)N[C@@H]2CNCC[C@H]2c2cccc(F)c2)c1 CHEMBL4451854 IC50 1.26 nM
N[C@H](COc1cncc(-c2ccc3cnccc3c2)c1)Cc1c[nH]c2ccccc12 CHEMBL383264 IC50 1.3 nM
Cc1n[nH]c2ccc(-c3cncc(OC[C@@H](N)Cc4ccc(Br)c(F)c4)c3)cc12 CHEMBL227367 IC50 1.3 nM
N[C@H](COc1cncc(-c2ccc3[nH]nc(-c4cccs4)c3c2)c1)Cc1c[nH]c2ccccc12 CHEMBL576733 IC50 1.3 nM
CC1(O)CC(N)(c2ccc(-c3nc4n(c3-c3ccccc3)COc3ccc(-c5cn[nH]c5)cc3-4)cc2)C1 CHEMBL3701763 IC50 1.3 nM
CC1(O)CC(N)(c2ccc(-c3nc4n(c3-c3ccccc3)COc3cc(C(N)=O)ccc3-4)cc2)C1 CHEMBL3701776 IC50 1.3 nM
N#Cc1c(N)ncnc1N1CCC(c2nc(-c3cnc(F)c(Cl)c3)cn2CCN2CCC2)CC1 CHEMBL3966203 IC50 1.3 nM
C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(C(=O)[C@H](CNCCC(=O)NCCCCCCCCNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)c4ccc(Cl)cc4)CC3)c21 CHEMBL5091595 Kd 1.3 nM
COC1CCC(NC[C@@H](C(=O)N2CCN(c3ncnc4c3[C@H](C)CC(=O)N4)[C@H]3C[C@H]32)c2ccc(Cl)cc2)CC1 CHEMBL5193325 IC50 1.3 nM
Nc1ncccc1-c1nc2ccc(-c3ccccc3)nc2n1-c1ccc(C2(N)CCC2)cc1 CHEMBL4297188 IC50 1.3 nM
CNC(=O)C[C@@H]1C[C@@H](c2ccc(F)c(F)c2)[C@H](NC(=O)c2cc(-c3c(Cl)cnn3C)c(Cl)o2)CN1 CHEMBL4440965 IC50 1.37 nM
N[C@H](COc1cncc(-c2ccc3c(c2)/C(=C\c2ccco2)C(=O)N3)c1)Cc1ccccc1 CHEMBL226849 IC50 1.4 nM
N[C@H](COc1cncc(-c2ccc3c(c2)C(Cc2ccco2)C(=O)N3)c1)Cc1ccccc1 CHEMBL575811 IC50 1.4 nM
CCc1c[nH]c2ncnc(N3CC[C@](N)(CNC(=O)c4ccc(F)cc4)C3)c12 CHEMBL1170261 IC50 1.4 nM
NC1(c2ccc(-c3nc4n(c3-c3ccccc3)COc3ncccc3-4)cc2)CC(O)(C2CC2)C1 CHEMBL3701752 IC50 1.4 nM
CC1(O)CC(N)(c2ccc(-c3nc4n(c3-c3ccccc3)COc3ncccc3-4)cc2)C1 CHEMBL3701753 IC50 1.4 nM
CC(C)(O)C(=O)Nc1cccc(-c2ccc3nc(-c4cccnc4N)n(-c4ccc(C5(N)CCC5)cc4)c3n2)c1 CHEMBL3640735 Kd 1.4 nM
CCC(=O)N1CCN(c2cccc(-c3ccc4nc(-c5cccnc5N)n(-c5ccc(C6(N)CCC6)cc5)c4n3)c2)CC1 CHEMBL3640742 Kd 1.4 nM
CNCCn1cc(-c2ccnc(C(F)(F)F)c2)nc1C1CCN(c2ncnc(N)c2Cl)CC1 CHEMBL3948454 IC50 1.4 nM
Nc1ncnc(N2CCC(c3nc(-c4ccc(F)c(C(F)(F)F)c4)cn3CCN3CCC3)CC2)c1C=O CHEMBL3890352 IC50 1.4 nM
Cc1cc(-c2cn(CCNCC(C)C)c(C3CCN(c4ncnc(N)c4C#N)CC3)n2)ccc1F CHEMBL3954981 IC50 1.4 nM
C[C@H](n1cnnc1-c1nc(NC(=O)c2cc(-n3cnc(C4CC4)c3)c(N3CC(C)(C#N)C3)cn2)cs1)C(F)(F)F CHEMBL3893968 IC50 1.4 nM
Cn1ncc(Cl)c1-c1cc(C(=O)N[C@@H]2CN[C@H](CC(=O)NCCO)C[C@H]2c2ccc(Cl)c(Cl)c2)oc1Cl CHEMBL4554668 IC50 1.41 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL388978 IC50 1.5 nM
N[C@H](COc1cnc(-c2ccco2)c(-c2ccc3cnccc3c2)c1)Cc1c[nH]c2ccccc12 CHEMBL378843 IC50 1.5 nM
CC(C)(Cc1ccc[nH]1)C1C(=O)Nc2ccc(-c3cncc(OC[C@@H](N)Cc4c[nH]c5ccccc45)c3)cc21 CHEMBL377603 IC50 1.5 nM
O=C1Nc2ccc(N[C@H](COc3cncc(-c4ccc5c(c4)C(F)(F)C(=O)N5)c3)Cc3c[nH]c4ccccc34)cc2C1(F)F CHEMBL212067 IC50 1.5 nM
N[C@H](COc1cncc(-c2ccc3[nH]ncc3c2)c1)Cc1c[nH]c2ccccc12 CHEMBL374805 IC50 1.5 nM
N[C@H](COc1cncc(-c2ccc3c(c2)C(F)(F)C(=O)N3)c1)Cc1c[nH]c2ccccc12 CHEMBL577377 IC50 1.5 nM
N[C@H](COc1cncc(-c2ccc3c(c2)C(c2ccc[nH]2)C(=O)N3)c1)Cc1c[nH]c2ccccc12 CHEMBL576348 IC50 1.5 nM
CNC(=O)c1ccc2c(c1)-c1nc(-c3ccc(C4(N)CC(C)(O)C4)cc3)c(-c3ccccc3)n1CO2 CHEMBL3701766 IC50 1.5 nM
CNCCn1cc(-c2ccnc(C(F)(F)F)c2)nc1C1CCN(c2ncnc(N)c2Br)CC1 CHEMBL3899490 IC50 1.5 nM
N#Cc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(Cl)c3)cn2CCN2CCCC2)CC1 CHEMBL3967010 IC50 1.5 nM
CNCCn1cc(-c2ccc(F)c(C(F)(F)F)c2)nc1C1CCN(c2ncnc(N)c2C#N)CC1 CHEMBL3894849 IC50 1.5 nM
CCOc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C(F)(F)F)c3)cn2CCNC(C)C)CC1 CHEMBL3912471 IC50 1.5 nM
C[C@H](n1cnnc1-c1nc(NC(=O)c2cc(-n3cnc(C4CC4)c3)c(N3CCC(C(F)(F)F)CC3)cn2)cs1)C(F)(F)F CHEMBL3976987 IC50 1.5 nM
O=C(N1CCN(c2ncnc3[nH]cc(Br)c23)CC1)C1(c2ccc(Cl)cc2)CCNCC1 CHEMBL4207231 IC50 1.5 nM
CC(C)NC[C@@H](C(=O)N1CCN(c2ncnc3c2[C@H](C)OC(=O)N3)CC1)c1ccc(Cl)cc1 CHEMBL5175332 IC50 1.5 nM
CC1(O)CC(N)(c2ccc(-c3nc4n(c3-c3ccccc3)COc3ccc(C(N)=O)cc3-4)cc2)C1 CHEMBL3701767 IC50 1.6 nM
NC1(c2ccc(-c3nc4n(c3-c3ccccc3)COc3cnccc3-4)cc2)CC(O)(C2CC2)C1 CHEMBL3701749 IC50 1.6 nM
Nc1ncnc(N2CCC(c3nc(-c4ccc(F)c(C(F)(F)F)c4)cn3CCN3CCC3)CC2)c1-c1cnoc1 CHEMBL3941451 IC50 1.6 nM
N#Cc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C(F)(F)F)c3)cn2CCNCC2CC2)CC1 CHEMBL3983282 IC50 1.6 nM
CC(C)NC[C@@H](C(=O)N1CCN(c2ncnc3c2[C@H](C)CC(=O)N3)CC1)c1ccc(Cl)cc1 CHEMBL5206905 IC50 1.6 nM
[2H]C1([2H])N(C(=O)[C@H](CNC(C)C)c2ccc(Cl)cc2)C([2H])([2H])C([2H])([2H])N(c2ncnc3c2[C@H](C)CC(=O)N3)C1([2H])[2H] CHEMBL5175628 IC50 1.6 nM
CC(C)NC[C@@H](C(=O)N1C[C@H]2CC[C@@H](C1)N2c1ncnc2c1[C@H](C)OC(=O)N2)c1ccc(Cl)cc1 CHEMBL5180219 IC50 1.6 nM
Cn1ncc(Br)c1-c1ccc2c(c1)CN([C@@H]1CNCC[C@H]1c1ccc(F)c(F)c1)C2=O CHEMBL5394710 IC50 1.6 nM
Nc1nccnc1-c1nc2ccc(-c3ccccc3)nc2n1-c1ccc(C2(N)CCC2)cc1 CHEMBL3649671 IC50 1.69 nM
CC(C)(C)C(=O)N1CCN(c2cccc(-c3ccc4nc(-c5cccnc5N)n(-c5ccc(C6(N)CCC6)cc5)c4n3)c2)CC1 CHEMBL3640745 Kd 1.7 nM
CNCCn1cc(-c2ccnc(C(F)(F)F)c2)nc1C1CCN(c2ncnc(N)c2C#N)CC1 CHEMBL3949795 IC50 1.7 nM
Nc1ncnc(N2CCC(c3nc(-c4ccc(F)c(F)c4)cn3CCN3CCCC3)CC2)c1Br CHEMBL3944201 IC50 1.7 nM
CCOc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C)c3)cn2CCN(C)C)CC1 CHEMBL3948085 IC50 1.7 nM
CNCCn1cc(-c2ccc(F)c(C)c2)nc1C1CCN(c2ncnc(N)c2C#N)CC1 CHEMBL3969016 IC50 1.7 nM
C[C@H](n1cnnc1-c1nc(NC(=O)c2cc(-n3cnc(C4CC4)c3)c(N3CC(C(F)F)C3)cn2)cs1)C(F)(F)F CHEMBL3930015 IC50 1.7 nM
C[C@H](n1cnnc1-c1nc(NC(=O)c2cc(-n3cnc(C4CC4)c3)c(N3CCC(C#N)CC3)cn2)cs1)C(F)(F)F CHEMBL3917308 IC50 1.7 nM
C[C@H](n1cnnc1-c1nc(NC(=O)c2cc(-n3cnc(C4CC4)c3)c(N3CCC(F)CC3)cn2)cs1)C(F)(F)F CHEMBL3962884 IC50 1.7 nM
CCOC(=O)c1c(C)nc(NNC(=O)c2cccc3c(=O)c4ccccc4[nH]c23)nc1-c1ccc(OC)cc1 CHEMBL4169791 IC50 1.72 nM
N[C@H](COc1cnc(Cl)c(-c2ccc3cnccc3c2)c1)Cc1c[nH]c2ccccc12 CHEMBL378963 IC50 1.8 nM
N[C@H](COc1cncc(-c2ccc3[nH]nc(C(F)(F)F)c3c2)c1)Cc1c[nH]c2ccccc12 CHEMBL374808 IC50 1.8 nM
Cc1n[nH]c2ccc(-c3cncc(OC[C@@H](N)Cc4ccc(F)c(C(F)(F)F)c4)c3)cc12 CHEMBL226627 IC50 1.8 nM
Cc1n[nH]c2ccc(-c3cncc(OC[C@@H](N)Cc4ccc(Cl)c(Cl)c4)c3)cc12 CHEMBL229968 IC50 1.8 nM
CCc1c[nH]c2ncnc(N3CC[C@](N)(CNC(=O)c4ccc(Cl)cc4)C3)c12 CHEMBL1170446 IC50 1.8 nM
CCNC(=O)c1ccc2c(c1)-c1nc(-c3ccc(C4(N)CC(C)(O)C4)cc3)c(-c3ccccc3)n1CO2 CHEMBL3701769 IC50 1.8 nM
CCONC(=O)c1ccc2c(c1)-c1nc(-c3ccc(C4(N)CC(C)(O)C4)cc3)c(-c3ccccc3)n1CO2 CHEMBL3701775 IC50 1.8 nM
CNC(=O)c1ccc2c(c1)OCn1c-2nc(-c2ccc(C3(N)CC(C)(O)C3)cc2)c1-c1ccccc1 CHEMBL3701770 IC50 1.8 nM
COc1ccc2c(c1)-c1nc(-c3ccc(C4(N)CC(O)(C5CC5)C4)cc3)c(-c3ccccc3)n1CO2 CHEMBL3701733 IC50 1.8 nM
Nc1ncnc(N2CCC(c3nc(-c4ccc(F)c(Cl)c4)cn3CCN3CCCC3)CC2)c1Br CHEMBL3980219 IC50 1.8 nM
COC1(C)CN(c2cnc(C(=O)Nc3csc(-c4nncn4C4CC4)n3)cc2-n2cnc(C3CC3)c2)C1 CHEMBL3905950 IC50 1.8 nM
C[C@H](n1cnnc1-c1nc(NC(=O)c2cc(-n3cnc(C4CC4)c3)c(N3CCN4CCCC4C3)cn2)cs1)C(F)(F)F CHEMBL3979677 IC50 1.8 nM
C[C@H](n1cnnc1-c1nc(NC(=O)c2cc(-n3cnc(C4CC4)c3)c(N3CCN(C4CC4)CC3)cn2)cs1)C(F)(F)F CHEMBL3925596 IC50 1.8 nM
C[C@H](n1cnnc1-c1nc(NC(=O)c2cc(-n3cnc(C4CC4)c3)c(N3CCN(CC4CC4)CC3)cn2)cs1)C(F)(F)F CHEMBL3897512 IC50 1.8 nM
O=C(N1CCN(c2ncnc3[nH]cc(Cl)c23)CC1)C1(c2ccc(Br)cc2)CCNCC1 CHEMBL4202879 IC50 1.8 nM
Cn1ncc(Cl)c1-c1ccc(C(=O)N[C@@H]2CNCC[C@H]2c2ccc(Cl)cc2)s1 CHEMBL4454791 IC50 1.8 nM
Cn1nccc1-c1ccc(C(=O)N[C@@H]2CNCC[C@H]2c2cc(F)cc(F)c2)cc1F CHEMBL4874391 IC50 1.8 nM
C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(C(=O)[C@H](CNCCC(=O)NCCCCCCCCNc4cccc5c4C(=O)N(C4CCC(=O)N(C)C4=O)C5=O)c4ccc(Cl)cc4)CC3)c21 CHEMBL5082198 Kd 1.8 nM
NC1(Cc2ccc(Cl)cc2Cl)CCN(c2ncnc3[nH]ccc23)CC1 CHEMBL597414 IC50 1.9 nM
CCn1c(-c2nonc2N)nc2c(C#CC(C)(C)O)nc(O[C@H](CCN)c3ccccc3)cc21 CHEMBL1099298 Ki 1.9 nM
N#Cc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(Cl)c3)cn2CCN2CCC2)CC1 CHEMBL3940867 IC50 1.9 nM
Nc1ncnc(N2CCC(c3nc(-c4ccc(F)c(C(F)(F)F)c4)cn3CCN3CCC3)CC2)c1-c1cc[nH]c1 CHEMBL3965271 IC50 1.9 nM
Cc1cc(-c2cn(CCN(C)C)c(C3CCN(c4ncnc(N)c4OC(C)C)CC3)n2)ccc1F CHEMBL3984164 IC50 1.9 nM
CC(C)(C)NCCn1cc(-c2ccc(F)c(C(F)(F)F)c2)nc1C1CCN(c2ncnc(N)c2C#N)CC1 CHEMBL3895898 IC50 1.9 nM
CC1(C#N)CN(c2cnc(C(=O)Nc3csc(-c4nncn4C4CC4)n3)cc2-n2cnc(C3CC3)c2)C1 CHEMBL3935565 IC50 1.9 nM
O=C(Nc1csc(-c2nncn2C2CC2)n1)c1cc(-n2cnc(C3CC3)c2)c(N2CCC3(CC2)COC3)cn1 CHEMBL3948895 IC50 1.9 nM
COC1CCN(c2cnc(C(=O)Nc3csc(-c4nncn4[C@@H](C)C(F)(F)F)n3)cc2-n2cnc(C3CC3)c2)C1 CHEMBL3909615 IC50 1.9 nM
C[C@H](n1cnnc1-c1nc(NC(=O)c2cc(-n3cnc(C4CC4)c3)c(N3CCCOCC3)cn2)cs1)C(F)(F)F CHEMBL3954144 IC50 1.9 nM
C[C@H](n1cnnc1-c1nc(NC(=O)c2cc(-n3cnc(C4CC4)c3)c(N3CC(N4CCOCC4)C3)cn2)cs1)C(F)(F)F CHEMBL3924482 IC50 1.9 nM
O=C(N1CCN(c2ncnc3[nH]cc(Cl)c23)CC1)C1(c2ccc(Cl)cc2)CCNCC1 CHEMBL4204854 IC50 1.9 nM
Nc1cccc(-c2ccc3nc(-c4cccnc4N)n(-c4ccc(C5(N)CCC5)cc4)c3n2)c1 CHEMBL4574111 IC50 1.9 nM
Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@H]2C[C@H](O)CN2C(=O)[C@@H](NC(=O)CCCCCCCCCCC(=O)NCCNC[C@@H](C(=O)N2CCN(c3ncnc4c3[C@H](C)C[C@H]4O)CC2)c2ccc(Cl)cc2)C(C)(C)C)cc1 CHEMBL5073195 Kd 1.9 nM
CC(C)NC[C@@H](C(=O)N1C2CCC1CN(c1ncnc3c1N(C)CC(=O)N3)C2)c1ccc(Cl)cc1 CHEMBL5190230 IC50 1.9 nM
O=C(N[C@@H]1CNCC[C@H]1c1cccc(F)c1)c1cc2c(s1)CCCn1nccc1-2 CHEMBL5440366 IC50 1.9 nM
Cn1ncc(Cl)c1-c1cc(C(=O)N[C@@H]2CN[C@H](CC(=O)O)C[C@H]2c2ccc(Cl)c(Cl)c2)oc1Cl CHEMBL4447967 IC50 1.94 nM
NC1(c2ccc(-n3c(C4CC4)nc4ccc(-c5cccc(N6CCOCC6)c5)nc43)cc2)CCC1 CHEMBL3649668 IC50 1.99 nM
C=Cc1ncc(OC[C@@H](N)Cc2c[nH]c3ccccc23)cc1-c1ccc2cnccc2c1 CHEMBL209513 IC50 2.0 nM
CCn1c(-c2nonc2N)nc2c(C#CC(C)(C)O)ncc(OCCN)c21 CHEMBL453510 IC50 2.0 nM
CCn1c(-c2nonc2N)nc2c(C#CCO)ncc(OCCCN)c21 CHEMBL523523 IC50 2.0 nM
CNCC(Cc1ccccc1)NC(=O)c1cc(Br)c(-c2ccnc3[nH]ccc23)s1 CHEMBL469591 IC50 2.0 nM
NC[C@H](Cc1ccncc1)NC(=O)c1cc(Br)c(-c2ccnc3[nH]ccc23)s1 CHEMBL498051 Ki 2.0 nM
NC[C@H](Cc1ccc(C(F)(F)F)cc1)NC(=O)c1cc(Br)c(-c2ccnc3[nH]ccc23)s1 CHEMBL482537 IC50 2.0 nM
Cc1n[nH]c2ncc(-c3cc(OC[C@@H](N)Cc4c[nH]c5ccccc45)cnc3-c3ccoc3)nc12 CHEMBL596290 IC50 2.0 nM
CCn1c(-c2nonc2N)nc2c(C#CC(C)(C)O)ncc(OC[C@@H]3CCCNC3)c21 CHEMBL521642 IC50 2.0 nM
CCn1c(-c2nonc2N)nc2c(C#CC(C)(C)O)nc(CN(C)C)cc21 CHEMBL1099290 IC50 2.0 nM
N#Cc1c[nH]c2ncnc(N3CC4(CCNCC4)c4ccccc43)c12 CHEMBL258837 IC50 2.0 nM
CCc1c[nH]c2ncnc(N3CCN(C(=O)[C@H](N)Cc4ccc(Cl)cc4)CC3)c12 CHEMBL1258665 IC50 2.0 nM
N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ncnc3[nH]cc(C4CC4)c23)CC1 CHEMBL1258780 IC50 2.0 nM
Cc1c[nH]c2ncnc(N3CCN(C(=O)[C@H](CN)Cc4ccc(Cl)cc4)CC3)c12 CHEMBL1258900 IC50 2.0 nM
NC[C@@H](C(=O)N1CCN(c2ncnc3[nH]ccc23)CC1)c1ccc(Cl)cc1 CHEMBL1257402 IC50 2.0 nM
NC[C@@H](C(=O)N1CCN(c2ncnc3[nH]cc(Cl)c23)CC1)c1ccc(Cl)c(Cl)c1 CHEMBL1257512 IC50 2.0 nM
C[C@@H]1SCc2ncnc(N3CCN(C(=O)[C@H](N)Cc4ccc(Cl)c(F)c4)CC3)c21 CHEMBL1632375 IC50 2.0 nM
CC(C)NCC(Cc1ccc(Cl)c(F)c1)C(=O)N1CCN(c2ncnc3c2[C@H](C)SC3)CC1 CHEMBL1632368 IC50 2.0 nM
CCOCCN(C[C@@H](O)CN1CCCC2(CCN(c3ncnc4[nH]cc(C)c34)C2)C1)S(=O)(=O)c1c(C)cccc1C CHEMBL1760759 IC50 2.0 nM
C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(C(=O)[C@H](CNC(C)(C)CO)c4ccc(Cl)cc4)CC3)c21 CHEMBL2177378 IC50 2.0 nM
C=C[C@@H]1CCc2ncnc(N3CCN(C(=O)[C@H](CNC(C)C)c4ccc(Cl)cc4)CC3)c21 CHEMBL2177387 IC50 2.0 nM
CN(C)CCC(NC(=O)C1(N)CCN(c2ncnc3[nH]ccc23)CC1)c1ccc(Cl)cc1 CHEMBL2325992 IC50 2.0 nM
CC1(O)CC(N)(c2ccc(-c3nc4n(c3-c3ccccc3)COc3cnccc3-4)cc2)C1 CHEMBL3701750 IC50 2.0 nM
CC1Cc2c(ccc(F)c2F)N1C(=O)Cc1nc(N2CCOCC2)c(F)c(=O)[nH]1 CHEMBL3931890 IC50 2.0 nM
CC1Cc2c(ccc(F)c2Cl)N1C(=O)Cc1nc(N2CCOCC2)c(F)c(=O)[nH]1 CHEMBL3970127 IC50 2.0 nM
CC1Cc2cc(F)ccc2N1C(=O)Cc1nc(N2CCOCC2)cc(=O)[nH]1 CHEMBL3932198 IC50 2.0 nM
CC1Cc2cc(F)c(F)cc2N1C(=O)Cc1nc(N2CCOCC2)cc(=O)[nH]1 CHEMBL3925163 IC50 2.0 nM
O=C(Cc1nc(N2CCOCC2)cc(=O)[nH]1)N1c2ccccc2CC1c1ccc(F)cc1 CHEMBL3914007 IC50 2.0 nM
CC1Cc2c(cccc2C(F)(F)F)N1C(=O)Cc1nc(N2CCOCC2)cc(=O)[nH]1 CHEMBL3940961 IC50 2.0 nM
Cc1cc(-c2cn(CCN3CCC3)c(C3CCN(c4ncnc(N)c4C#N)CC3)n2)ccc1F CHEMBL3961056 IC50 2.0 nM
CC(C)Oc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(Cl)c3)cn2CCN2CCCC2)CC1 CHEMBL3904291 IC50 2.0 nM
COCC1CN(c2cnc(C(=O)Nc3csc(-c4nncn4[C@@H](C)C(F)(F)F)n3)cc2-n2cnc(C3CC3)c2)C1 CHEMBL3946920 IC50 2.0 nM
COC1(C)CN(c2cnc(C(=O)Nc3csc(-c4nncn4[C@@H](C)C(F)(F)F)n3)cc2-n2cnc(C3CC3)c2)C1 CHEMBL3953748 IC50 2.0 nM
C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(C(=O)[C@H](CNCCCCCCCCCCCc4cccc5c4CN(C4CCC(=O)NC4=O)C5=O)c4ccc(Cl)cc4)CC3)c21 CHEMBL5288938 IC50 2.0 nM
Cc1[nH]c2ccccc2c1C[C@H](N)COc1cncc(-c2ccc3[nH]nc(C)c3c2)c1 CHEMBL208790 Ki 2.1 nM
Cc1n[nH]c2ccc(-c3cncc(OC[C@@H](N)Cc4cccc(Br)c4)c3)cc12 CHEMBL390372 IC50 2.1 nM
CCONC(=O)c1ccc2c(c1)OCn1c-2nc(-c2ccc(C3(N)CC(C)(O)C3)cc2)c1-c1ccccc1 CHEMBL3701773 IC50 2.1 nM
CCc1c(N)ncnc1N1CCC(c2nc(-c3ccnc(C(F)(F)F)c3)cn2CCNC)CC1 CHEMBL3910789 IC50 2.1 nM
CCOc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C)c3)cn2CCN2CCC2)CC1 CHEMBL3916178 IC50 2.1 nM
CCOc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(Cl)c3)cn2CCN2CCCC2)CC1 CHEMBL3928772 IC50 2.1 nM
C[C@H](n1cnnc1-c1nc(NC(=O)c2cc(-n3cnc(C4CC4)c3)c(N3CCC(F)(F)C3)cn2)cs1)C(F)(F)F CHEMBL3961734 IC50 2.1 nM
C[C@H](n1cnnc1-c1nc(NC(=O)c2cc(-n3cnc(C4CC4)c3)c(N3CCC4(CC3)COC4)cn2)cs1)C(F)(F)F CHEMBL3961404 IC50 2.1 nM
O=C(NCc1cccc(O)c1)Nc1nc(-c2ccncc2)cs1 CHEMBL3218297 IC50 2.16 nM
CC1(O)CC(N)(c2ccc(-c3nc4n(c3-c3ccccc3)COc3ccc(CO)cc3-4)cc2)C1 CHEMBL3701758 IC50 2.2 nM
Nc1ncnc(N2CCC(c3nc(-c4ccnc(C(F)(F)F)c4)cn3CCN3CCC3)CC2)c1Br CHEMBL3977147 IC50 2.2 nM
C=Cc1c(N)ncnc1N1CCC(c2nc(-c3ccnc(C(C)C)c3)cn2CCN2CCC2)CC1 CHEMBL3891980 IC50 2.2 nM
Nc1ncnc(N2CCC(c3nc(-c4ccc(F)c(C(F)(F)F)c4)cn3CCN3CCCC3)CC2)c1Cl CHEMBL3986793 IC50 2.2 nM
O=C(Nc1csc(-c2nncn2C2CC2)n1)c1cc(-n2cnc(C3CC3)c2)c(N2CC(C(F)F)C2)cn1 CHEMBL3908126 IC50 2.2 nM
N#CC1CCN(c2cnc(C(=O)Nc3csc(-c4nncn4C4CC4)n3)cc2-n2cnc(C3CC3)c2)CC1 CHEMBL3898363 IC50 2.2 nM
COC1(C)CCN(c2cnc(C(=O)Nc3csc(-c4nncn4[C@@H](C)C(F)(F)F)n3)cc2-n2cnc(C3CC3)c2)CC1 CHEMBL3893936 IC50 2.2 nM
C[C@H](n1cnnc1-c1nc(NC(=O)c2cc(-n3cnc(C4CC4)c3)c(N3CC4CC4C3)cn2)cs1)C(F)(F)F CHEMBL3953359 IC50 2.2 nM
N=C(c1ccccc1)n1c(=N)ccc2nc(-c3ccc(C4(N)CCC4)cc3)c(-c3ccccc3)cc21 CHEMBL3679633 IC50 2.3 nM
NC1(c2ccc(-c3nc4n(c3-c3ccccc3)COc3c(F)cccc3-4)cc2)CC(O)(C2CC2)C1 CHEMBL3701726 IC50 2.3 nM
COc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C)c3)cn2CC2CNC2)CC1 CHEMBL3981085 IC50 2.3 nM
CCc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C)c3)cn2CC2CNC2)CC1 CHEMBL3967750 IC50 2.3 nM
Nc1ncnc(N2CCC(c3nc(-c4ccc(F)c(C(F)(F)F)c4)cn3CCN3CCC3)CC2)c1Br CHEMBL3894578 IC50 2.3 nM
Nc1ncnc(N2CCC(c3nc(-c4ccc(F)c(C(F)(F)F)c4)cn3CCN3CCC3)CC2)c1-c1ccc(F)cc1 CHEMBL3903522 IC50 2.3 nM
N#Cc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C(F)(F)F)c3)cn2CCN2CCCCC2)CC1 CHEMBL3927877 IC50 2.3 nM
Cc1cc(-c2cn(CCNCC3CC3)c(C3CCN(c4ncnc(N)c4C#N)CC3)n2)ccc1F CHEMBL3972479 IC50 2.3 nM
O=C(Nc1csc(-c2nncn2C2CC2)n1)c1cc(-n2cnc(C3CC3)c2)c(N2CC(N3CCOCC3)C2)cn1 CHEMBL3986247 IC50 2.3 nM
COC1CCN(c2cnc(C(=O)Nc3csc(-c4nncn4[C@@H](C)C(F)(F)F)n3)cc2-n2cnc(C3CC3)c2)CC1 CHEMBL3904498 IC50 2.3 nM
CNC(=O)C1CCN(c2cnc(C(=O)Nc3csc(-c4nncn4[C@@H](C)C(F)(F)F)n3)cc2-n2cnc(C3CC3)c2)CC1 CHEMBL3908356 IC50 2.3 nM
C[C@H](n1cnnc1-c1nc(NC(=O)c2cc(-n3cnc(C4CC4)c3)c(N3CCN4C(=O)OCC4C3)cn2)cs1)C(F)(F)F CHEMBL3926976 IC50 2.3 nM
CC(=O)Nc1cccc(-c2ccc3nc(-c4cccnc4N)n(-c4ccc(C5(N)CCC5)cc4)c3n2)c1 CHEMBL4519558 IC50 2.3 nM
Cc1ccc(C[C@H](N)COc2cncc(-c3ccc4[nH]nc(C)c4c3)c2)cc1F CHEMBL227050 IC50 2.4 nM
CC1(O)CC(N)(c2ccc(-c3nc4n(c3-c3ccccc3)COc3ccc(C(=O)NCCO)cc3-4)cc2)C1 CHEMBL3701774 IC50 2.4 nM
COc1cc(-c2cn(CCN3CCC3)c(C3CCN(c4ncnc(N)c4C#N)CC3)n2)ccc1F CHEMBL3938454 IC50 2.4 nM
COc1cc(-c2cn(CCN3CCC3)c(C3CCN(c4ncnc(N)c4C(N)=O)CC3)n2)ccc1F CHEMBL3933597 IC50 2.4 nM
CC(C)c1cc(-c2cn(CCN3CCC3)c(C3CCN(c4ncnc(N)c4Cl)CC3)n2)ccn1 CHEMBL3912769 IC50 2.4 nM
C[C@H](n1cnnc1-c1nc(NC(=O)c2cc(-n3cnc(C4CC4)c3)c(N3CC4CN(C)CC4C3)cn2)cs1)C(F)(F)F CHEMBL3899813 IC50 2.4 nM
CC(C)NC[C@@H](C(=O)N1CCN(c2ncnc3c2C(C)CC(=O)N3)CC1)c1ccc(Cl)cc1 CHEMBL5187287 IC50 2.4 nM
C[C@H](O)CNC(=O)c1cccc(-c2ccc3nc(-c4cccnc4N)n(-c4ccc(C5(N)CCC5)cc4)c3n2)c1 CHEMBL3640736 IC50 2.45 nM
CC(=O)NCC[C@@H]1C[C@@H](c2ccc(F)c(F)c2)[C@H](NC(=O)c2cc(-c3c(Cl)cnn3C)c(Cl)o2)CN1 CHEMBL4460525 IC50 2.49 nM
Cc1cc(C[C@H](N)COc2cncc(-c3ccc4[nH]nc(C)c4c3)c2)ccc1Br CHEMBL226996 IC50 2.5 nM
COc1cc2c(cc1Nc1nc(Nc3cccc4c3C(=O)NC4)c3cc[nH]c3n1)N(C(=O)CN(C)C)CC2 CHEMBL517163 IC50 2.5 nM
Cc1cc(C[C@H](N)COc2cncc(-c3cc4c(C)n[nH]c4cn3)c2)ccc1F CHEMBL573359 IC50 2.5 nM
Nc1ncnc(N2CCC(c3nc(-c4ccnc(C(F)(F)F)c4)cn3CCN3CCC3)CC2)c1Cl CHEMBL3980922 IC50 2.5 nM
CCN(CC)CCn1cc(-c2ccc(F)c(C)c2)nc1C1CCN(c2ncnc(N)c2C#N)CC1 CHEMBL3896910 IC50 2.5 nM
COCCNCCn1cc(-c2ccc(F)c(C(F)(F)F)c2)nc1C1CCN(c2ncnc(N)c2C#N)CC1 CHEMBL3903066 IC50 2.5 nM
CC(C)NCCn1cc(-c2ccc(F)c(C(F)(F)F)c2)nc1C1CCN(c2ncnc(N)c2C(N)=O)CC1 CHEMBL3919834 IC50 2.5 nM
O=C(Nc1csc(-c2nncn2C2CC2)n1)c1cc(-n2cnc(C3CC3)c2)c(N2CCC(F)CC2)cn1 CHEMBL3920406 IC50 2.5 nM
O=C(Nc1csc(-c2nncn2C2CC2)n1)c1cc(-n2cnc(C3CC3)c2)c(N2CCN(CC3CC3)CC2)cn1 CHEMBL3978053 IC50 2.5 nM
Cn1ncc(Cl)c1-c1cc(C(=O)N[C@@H]2CNCC[C@@H]2c2ccc(F)c(F)c2)oc1Cl CHEMBL4552655 IC50 2.5 nM
Cn1ncc(Cl)c1-c1cc(C(=O)N[C@@H]2CN[C@H](CCCO)C[C@H]2c2ccc(Cl)c(Cl)c2)oc1Cl CHEMBL4451765 IC50 2.56 nM
Oc1nnc2c3cc(-c4ccccc4)c(-c4ccc(CN5CCC(c6n[nH]c(-c7ccccn7)n6)CC5)cc4)nc3ccn12 CHEMBL506077 IC50 2.6 nM
N[C@H](COc1cncc(-c2ccc3[nH]nc(C4CC4)c3c2)c1)Cc1c[nH]c2ccccc12 CHEMBL572907 IC50 2.6 nM
N[C@]1(CNC(=O)c2ccc(F)cc2)CCN(c2ncnc3[nH]cc(Cl)c23)C1 CHEMBL1169610 IC50 2.6 nM
N#Cc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C(F)(F)F)c3)cn2CCN2CCC2)CC1 CHEMBL3962807 IC50 2.6 nM
CCc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C)c3)cn2CCN(CC)CC)CC1 CHEMBL3891820 IC50 2.6 nM
CCN(CC)CCn1cc(-c2ccc(F)c(C)c2)nc1C1CCN(c2ncnc(N)c2OC(C)C)CC1 CHEMBL3913659 IC50 2.6 nM
C[C@H](n1cnnc1-c1nc(NC(=O)c2cc(-n3cnc(C4CC4)c3)c(N3CC4(CCOCC4)C3)cn2)cs1)C(F)(F)F CHEMBL3903012 IC50 2.6 nM
CNC(=O)C[C@@H]1C[C@@H](c2ccc(Cl)c(Cl)c2)[C@H](NC(=O)c2cc(-c3c(Cl)cnn3C)c(Cl)o2)CN1 CHEMBL4475923 IC50 2.64 nM
NC1(Cc2ccc(Cl)cc2)CCN(c2ccnc3[nH]ncc23)CC1 CHEMBL598013 GI50 2.7 nM
Cn1cc(-c2ccc(F)c(C(F)(F)F)c2)nc1C1CCN(c2ncnc(N)c2-c2ccc(C#N)cc2)CC1 CHEMBL3897066 IC50 2.7 nM
Nc1ncnc(N2CCC(c3nc(-c4ccnc(C(F)(F)F)c4)cn3CCN3CCC3)CC2)c1-c1cnoc1 CHEMBL3908552 IC50 2.7 nM
Cc1cc(-c2cn(CCN3CCC3)c(C3CCN(c4ncnc(N)c4OC(C)C)CC3)n2)ccc1F CHEMBL3985943 IC50 2.7 nM
Nc1ncnc(N2CCC(c3nc(-c4ccc(F)c(C(F)(F)F)c4)cn3CCN3CCC3)CC2)c1[N+](=O)[O-] CHEMBL3927590 IC50 2.7 nM
CC(C)N(C)CCn1cc(-c2ccc(F)c(C(F)(F)F)c2)nc1C1CCN(c2ncnc(N)c2C#N)CC1 CHEMBL3909180 IC50 2.7 nM
Cc1cc(-c2cn(CCN(C)C(C)C)c(C3CCN(c4ncnc(N)c4C#N)CC3)n2)ccc1F CHEMBL3963056 IC50 2.7 nM
O=C(Nc1csc(-c2nncn2C2CC2)n1)c1cc(-n2cnc(C3CC3)c2)c(N2CCN3CCCC3C2)cn1 CHEMBL3964706 IC50 2.7 nM
O=C(Nc1csc(-c2nncn2C2CC2)n1)c1cc(-n2cnc(C3CC3)c2)c(N2CCN3C(=O)OCC3C2)cn1 CHEMBL3963748 IC50 2.7 nM
Nc1ncccc1-c1nc2ccc(-c3ccccc3)nc2n1-c1ccc(C2(N)CCC2)cc1 CHEMBL4523032 IC50 2.7 nM
Cn1nccc1-c1ccc(C(=O)N[C@@H]2CNCC[C@H]2c2ccc(F)c(F)c2)cc1F CHEMBL4867422 IC50 2.7 nM
Cn1ncc(Cl)c1-c1cc(C(=O)N[C@@H]2CN[C@H](CCO)C[C@H]2c2ccc(Cl)c(Cl)c2)oc1Cl CHEMBL4517950 IC50 2.74 nM
Nc1nnc2c3cc(-c4ccccc4)c(-c4ccc(CN5CCC(c6n[nH]c(-c7ccccn7)n6)CC5)cc4)nc3ccn12 CHEMBL499555 IC50 2.8 nM
NC1(C(=O)NCc2ccc(Cl)cc2F)CCN(c2ncnc3[nH]ccc23)CC1 CHEMBL597600 GI50 2.8 nM
CCCc1cc(-c2cncc(OC[C@@H](N)Cc3c[nH]c4ccccc34)c2)cc2c(C)n[nH]c12 CHEMBL1254114 IC50 2.8 nM
Nc1ncnc(N2CCC(c3nc(-c4ccnc(C(F)(F)F)c4)cn3CCNCCCCl)CC2)c1Br CHEMBL3951747 IC50 2.8 nM
CCN(CCn1cc(-c2ccc(F)c(C)c2)nc1C1CCN(c2ncnc(N)c2C#N)CC1)C(C)C CHEMBL3957053 IC50 2.8 nM
O=C(Nc1csc(-c2nncn2C2CC2)n1)c1cc(-n2cnc(C3CC3)c2)c(N2CC(F)(F)C2)cn1 CHEMBL3957940 IC50 2.8 nM
COC1CCN(c2cnc(C(=O)Nc3csc(-c4nncn4C4CC4)n3)cc2-n2cnc(C3CC3)c2)C1 CHEMBL3895494 IC50 2.8 nM
O=C(Nc1csc(-c2nncn2C2CC2)n1)c1cc(-n2cnc(C3CC3)c2)c(N2CCN(C3CC3)CC2)cn1 CHEMBL3954180 IC50 2.8 nM
CC(C)NC[C@@H](C(=O)N1C2CCC1CN(c1ncnc3c1[C@H](C)CC(=O)N3)C2)c1ccc(Cl)cc1 CHEMBL5195745 IC50 2.8 nM
O=C(N[C@@H]1CNCC[C@H]1c1cc(F)cc(F)c1)c1ccc2c(c1)OCCn1ncc(Cl)c1-2 CHEMBL5409113 IC50 2.8 nM
N[C@H](COc1cncc(-c2cc3c(Cl)n[nH]c3cn2)c1)Cc1cccc(C(F)(F)F)c1 CHEMBL388312 IC50 2.9 nM
Nc1n[nH]c2ccc(-c3cncc(OC[C@@H](N)Cc4c[nH]c5ccccc45)c3)cc12 CHEMBL577795 IC50 2.9 nM
COc1ccc2c(c1)-c1nc(-c3ccc(C4(N)CC(C)(O)C4)cc3)c(-c3ccccc3)n1CO2 CHEMBL3701735 IC50 2.9 nM
N#Cc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C(F)(F)F)c3)cn2CC2CCCN2)CC1 CHEMBL3968352 IC50 2.9 nM
Nc1ncnc(N2CCC(c3nc(-c4ccc(F)cc4)cn3CCN3CCCC3)CC2)c1Br CHEMBL3911853 IC50 2.9 nM
Cc1cc(-c2cn(CCNC(C)C)c(C3CCN(c4ncnc(N)c4C#N)CC3)n2)ccc1F CHEMBL3890076 IC50 2.9 nM
O=C(Nc1csc(-c2nncn2C2CC2)n1)c1cc(-n2cnc(C3CC3)c2)c(N2CCN(CC(F)(F)F)CC2)cn1 CHEMBL3953443 IC50 2.9 nM
O=C(N1CCN(c2ncnc3[nH]cc(Cl)c23)CC1)C1(c2ccc(Cl)c(Cl)c2)CCNCC1 CHEMBL4213657 IC50 2.9 nM
Cn1ncc(Cl)c1-c1cc(C(=O)N[C@@H]2CNCC[C@H]2c2ccc(Cl)c(Cl)c2)oc1Cl CHEMBL4445510 IC50 2.9 nM
CCn1c(-c2nonc2N)nc2c(C#CC(C)(C)O)ncc(OCCCNC[C@H](O)CO)c21 CHEMBL522351 IC50 3.0 nM
CCn1c(-c2nonc2N)nc2c(C#CC(C)(C)O)ncc(OCC[C@@H](N)Cc3ccccc3)c21 CHEMBL523859 IC50 3.0 nM
NCC(C(=O)Nc1ccc(-c2ccnc3[nH]ccc23)s1)c1ccccc1 CHEMBL512480 IC50 3.0 nM
CNCC(NC(=O)c1cc(Br)c(-c2ccnc3[nH]ccc23)s1)c1ccccc1 CHEMBL470410 IC50 3.0 nM
COc1ccc(C[C@@H](CN)NC(=O)c2cc(Br)c(-c3ccnc4[nH]ccc34)s2)cc1 CHEMBL524998 IC50 3.0 nM
COc1ccc(-c2nnc(C3CCN(Cc4ccc(-c5nc6cc[nH]c(=O)c6cc5-c5ccccc5)cc4)CC3)[nH]2)cn1 CHEMBL446966 IC50 3.0 nM
CN(C)CC(=O)N1CCN(c2ncc3cc(-c4ccccc4)c(-c4ccc(CN5CCC(c6nnc(-c7ccccn7)[nH]6)CC5)cc4)nc3n2)CC1 CHEMBL447168 IC50 3.0 nM
Cc1n[nH]c2ccc(-c3cc(OC[C@@H](N)Cc4ccccc4)cnc3-c3cc(Cl)ccc3O)cc12 CHEMBL605733 IC50 3.0 nM
Cc1occc1-c1nc(N)c(OC[C@@H](N)Cc2c[nH]c3ccccc23)cc1-c1ccc2[nH]nc(C)c2c1 CHEMBL593374 IC50 3.0 nM
Cc1nc(-c2ccoc2)c(-c2cnc3[nH]nc(C)c3n2)cc1OC[C@@H](N)Cc1c[nH]c2ccccc12 CHEMBL594523 IC50 3.0 nM
N[C@H](CNc1nnc(-c2ccc3cnccc3c2)s1)Cc1ccc(C(F)(F)F)cc1 CHEMBL1080569 IC50 3.0 nM
CCn1c(-c2nonc2N)nc2c(C#CC(C)(C)O)nc(O[C@H](CN)c3ccccc3)cc21 CHEMBL1099296 Ki 3.0 nM
CCn1c(-c2nonc2N)nc2c(C#CC(C)(C)O)nc(CCCN)cc21 CHEMBL1097974 IC50 3.0 nM
CCn1c(-c2nonc2N)nc2c(C#CC(C)(C)O)nc(CNC)cc21 CHEMBL1098316 IC50 3.0 nM
CCn1c(-c2nonc2N)nc2c(C#CC(C)(C)O)nc(OC[C@H](N)c3ccccc3)cc21 CHEMBL1096634 IC50 3.0 nM
CCn1c(-c2nonc2N)nc2c(C#CC(C)(C)O)nc(OC[C@@H](N)Cc3ccccc3)cc21 CHEMBL1098939 IC50 3.0 nM
Cc1c[nH]c2ncnc(N3CC[C@](N)(CNC(=O)c4ccc(F)cc4)C3)c12 CHEMBL1171994 IC50 3.0 nM
Cc1c[nH]c2ncnc(N3CCN(C(=O)[C@H](N)Cc4ccc(F)cc4)CC3)c12 CHEMBL1257282 IC50 3.0 nM
CC(C)NCC(Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ncnc3c2[C@H](C)SC3)CC1 CHEMBL1632380 IC50 3.0 nM
C[C@@H]1SCc2ncnc(N3CCN(C(=O)C(Cc4ccc(Cl)cc4)CN4CCCC4)CC3)c21 CHEMBL1632381 IC50 3.0 nM
Cc1ccc(CC(CNC(C)C)C(=O)N2CCN(c3ncnc4c3[C@H](C)SC4)CC2)cc1 CHEMBL1632382 IC50 3.0 nM
C[C@@H]1SCc2ncnc(N3CCN(C(=O)C(Cc4ccc(Cl)c(F)c4)CC4(N)CC4)CC3)c21 CHEMBL1632386 IC50 3.0 nM
CC(C)NC[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ncnc3c2[C@H](C)OC3)CC1 CHEMBL1632391 IC50 3.0 nM
Cc1noc(C)c1S(=O)(=O)NC[C@@H](O)CN1CCC[C@@]2(CCN(c3ncnc(N)c3C3CC3)C2)C1 CHEMBL1760776 IC50 3.0 nM
C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(C(=O)[C@H](CNCC4CC4)c4ccc(C(F)(F)F)c(F)c4)CC3)c21 CHEMBL2177361 IC50 3.0 nM
C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(C(=O)[C@H](CNC(C)(C)C)c4ccc(C(F)(F)F)c(F)c4)CC3)c21 CHEMBL2178597 IC50 3.0 nM
CC(C)NC[C@@H](C(=O)N1CCN(c2ncnc3c2[C@H](C)C[C@H]3O)CC1)c1ccc(Cl)c(F)c1 CHEMBL2177372 IC50 3.0 nM
C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(C(=O)[C@H](CNCC4CCOCC4)c4ccc(Cl)cc4)CC3)c21 CHEMBL2177368 IC50 3.0 nM
C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(C(=O)[C@@H](c4ccc(Cl)cc4)[C@@H]4CCCN4)CC3)c21 CHEMBL2177379 IC50 3.0 nM
CC(C)NC[C@@H](C(=O)N1CCN(c2ncnc3c2[C@H](CF)CC3)CC1)c1ccc(Cl)cc1 CHEMBL2177388 IC50 3.0 nM
NC1(C(=O)N[C@@H](CCO)c2ccc(Cl)cc2)CCN(c2nc[nH]c3nccc2-3)CC1 CHEMBL2325741 IC50 3.0 nM
CN(C)CC[C@H](NC(=O)C1(N)CCN(c2ncnc3[nH]ccc23)CC1)c1ccc(Cl)cc1 CHEMBL2325727 IC50 3.0 nM
CN(C)CCCC(NC(=O)C1(N)CCN(c2ncnc3[nH]ccc23)CC1)c1ccc(Cl)cc1 CHEMBL2325993 IC50 3.0 nM
Cc1cccc(-c2nc(C3CCN(Cc4ccc(-c5nc6nccn6cc5-c5ccccc5F)cc4)CC3)n[nH]2)n1 CHEMBL3672065 IC50 3.0 nM
O=C(Cc1nc(N2CCOCC2)cc(=O)[nH]1)N1CCc2c(Cl)cccc21 CHEMBL3112849 IC50 3.0 nM
Cc1cccc2c1CCN2C(=O)Cc1nc(N2CCOCC2)cc(=O)[nH]1 CHEMBL3112851 IC50 3.0 nM
CC1Cc2cc(F)ccc2N1C(=O)Cc1nc(N2CCOCC2)c(F)c(=O)[nH]1 CHEMBL3918391 IC50 3.0 nM
CC1Cc2c(Br)cccc2N1C(=O)Cc1nc(N2CCOCC2)cc(=O)[nH]1 CHEMBL3971065 IC50 3.0 nM
Nc1ncnc(N2CCC(c3nc(-c4ccc(O)c(C(F)(F)F)c4)cn3CCN3CCCC3)CC2)c1Cl CHEMBL3961556 IC50 3.0 nM
C[C@@H]1CC(=O)Nc2ncnc(N3CCC(c4nc(-c5ccc(F)c(C(F)(F)F)c5)cn4CCN4CCCC4)CC3)c21 CHEMBL4128457 IC50 3.0 nM
Cn1ncc(Cl)c1-c1cc(C(=O)N[C@@H]2CNCC[C@H]2c2ccc(F)c(F)c2)oc1Cl CHEMBL4457064 IC50 3.0 nM
Nc1ncccc1-c1nc2ccc(-c3cccc(NC(=O)C4CC4)c3)nc2n1-c1ccc(C2(N)CCC2)cc1 CHEMBL3640732 IC50 3.09 nM
Cc1n[nH]c2ccc(-c3cncc(OC[C@@H](N)Cc4ccc(C(F)(F)F)c(F)c4)c3)cc12 CHEMBL375717 IC50 3.1 nM
Cc1n[nH]c2ccc(-c3cncc(OC[C@@H](N)Cc4ccc(F)c(Cl)c4)c3)cc12 CHEMBL375919 IC50 3.1 nM
Fc1ccc2c(c1)C1(CCNCC1)CN2c1ncnc2[nH]ccc12 CHEMBL407718 IC50 3.1 nM
CC1(O)CC(O)(c2ccc(-c3nc4n(c3-c3ccccc3)COc3cc(C(=O)O)ccc3-4)cc2)C1 CHEMBL3701778 IC50 3.1 nM
CC1(O)CC(N)(c2ccc(-c3nc4n(c3-c3ccccc3)COc3cc(C(=O)NCCO)ccc3-4)cc2)C1 CHEMBL3701772 IC50 3.1 nM
C[C@@H]1CN(c2cccc(-c3ccc4nc(-c5cccnc5N)n(-c5ccc(C6(N)CCC6)cc5)c4n3)c2)C[C@H](C)O1 CHEMBL3640746 Kd 3.1 nM
Cn1ncc(Cl)c1-c1cc(C(=O)N[C@@H]2CN[C@H](CC(=O)NCC(O)CO)C[C@H]2c2ccc(Cl)c(Cl)c2)oc1Cl CHEMBL4593086 IC50 3.13 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4cccc(OC(F)(F)F)c4)c3)cc12 CHEMBL1965836 pKi 3.162 nM
O=C1Cc2cc(N[C@H](COc3cncc(-c4ccc5c(c4)CC(=O)N5)c3)Cc3c[nH]c4ccccc34)ccc2N1 CHEMBL212566 IC50 3.2 nM
Cc1n[nH]c2ccc(-c3cncc(OC[C@@H](N)Cc4ccc5ccccc5c4)c3)cc12 CHEMBL210740 Ki 3.2 nM
N[C@H](COc1cncc(-c2ccc3c(c2)CC(=O)N3)c1)Cc1c[nH]c2ccccc12 CHEMBL579246 IC50 3.2 nM
Nc1ncnc(N2CCC(c3nc(-c4ccc(F)c(F)c4)cn3CCN3CCCC3)CC2)c1Cl CHEMBL3940627 IC50 3.2 nM
N#Cc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C(F)(F)F)c3)cn2CCN2CCCC2)CC1 CHEMBL3959291 IC50 3.2 nM
O=C(Nc1csc(-c2nncn2C2CC2)n1)c1cc(-n2cnc(C3CC3)c2)c(N2CCC(C(F)(F)F)CC2)cn1 CHEMBL3924518 IC50 3.2 nM
COC1CCN(c2cnc(C(=O)Nc3csc(-c4nncn4C4CC4)n3)cc2-n2cnc(C3CC3)c2)CC1 CHEMBL3943452 IC50 3.2 nM
O=C(N[C@@H]1CNCC[C@H]1c1cc(F)cc(F)c1)c1cc2c(s1)OCCn1nccc1-2 CHEMBL5407425 IC50 3.2 nM
Cn1ncc(Cl)c1-c1cc(C(=O)N[C@@H]2CN[C@H](CC(N)=O)C[C@H]2c2ccc(Cl)c(Cl)c2)oc1Cl CHEMBL4438877 IC50 3.24 nM
Cn1ncc(Cl)c1-c1cc(C(=O)N[C@@H]2CN[C@H](CCNS(C)(=O)=O)C[C@H]2c2ccc(F)c(F)c2)oc1Cl CHEMBL4441416 IC50 3.29 nM
CC(C)(CC1CC1)C1C(=O)Nc2ccc(-c3cncc(OC[C@@H](N)Cc4c[nH]c5ccccc45)c3)cc21 CHEMBL378827 IC50 3.3 nM
Cc1n[nH]c2ccc(-c3cncc(OC[C@@H](N)Cc4cccc(OC(F)(F)F)c4)c3)cc12 CHEMBL227271 IC50 3.3 nM
Nc1nnc2c3cc(-c4ccccc4)c(-c4ccc(CN5CCC(n6cnc(-c7ccccn7)c6)CC5)cc4)nc3ccn12 CHEMBL508794 IC50 3.3 nM
N[C@H](COc1cncc(-c2ccc3c(c2)C(C2CC2)C(=O)N3)c1)Cc1c[nH]c2ccccc12 CHEMBL574269 IC50 3.3 nM
N[C@]1(CNC(=O)c2ccc(Cl)cc2)CCN(c2ncnc3[nH]cc(Cl)c23)C1 CHEMBL1170445 IC50 3.3 nM
Nc1ncnc(N2CCC(c3nc(-c4ccc(F)cc4)cn3CCN3CCCC3)CC2)c1Cl CHEMBL3912632 IC50 3.3 nM
Cn1ncc(Cl)c1-c1cc(C(=O)N[C@@H]2CN[C@H](CC(O)CO)C[C@H]2c2ccc(F)c(F)c2)oc1Cl CHEMBL4567295 IC50 3.31 nM
Nc1cc2cc(-c3cncc(OC[C@@H](N)Cc4c[nH]c5ccccc45)c3)ccc2cn1 CHEMBL210390 IC50 3.4 nM
CC(=O)OCC[C@@H]1C[C@@H](c2ccc(F)c(F)c2)[C@H](NC(=O)c2cc(-c3c(Cl)cnn3C)c(Cl)o2)CN1 CHEMBL4531735 IC50 3.4 nM
CN(C)CC[C@@H]1C[C@@H](c2ccc(Cl)c(Cl)c2)[C@H](NC(=O)c2cc(-c3c(Cl)cnn3C)c(Cl)o2)CN1 CHEMBL4590906 IC50 3.4 nM
CN1CCN(C(C(=O)N2CCN(c3ncnc4[nH]cc(Br)c34)CC2)c2ccc(Cl)cc2)CC1 CHEMBL5286570 IC50 3.4 nM
NC1(c2ccc(-n3c(C4CCCCC4)nc4ccc(-c5cccc(N6CCOCC6)c5)nc43)cc2)CCC1 CHEMBL3649667 IC50 3.47 nM
N[C@H](COc1cncc(-c2ccc3cnc(F)cc3c2)c1)Cc1c[nH]c2ccccc12 CHEMBL210246 IC50 3.5 nM
N[C@H](COc1cncc(-c2ccc3cnccc3c2)c1)Cc1ccc2ccccc2c1 CHEMBL211018 Ki 3.5 nM
O=C1N=CC=C2N=C(c3ccc(CN4CCC(c5n[nH]c(-c6ccccn6)n5)CC4)cc3)C(c3ccccc3)=CC12 CHEMBL262341 IC50 3.5 nM
O=C1NCCc2nc(-c3ccc(CN4CCC(c5nnc(-c6ccccn6)[nH]5)CC4)cc3)c(-c3ccccc3)cc21 CHEMBL446134 IC50 3.5 nM
Cc1cc(-c2cn(CCN3CCCC3)c(C3CCN(c4ncnc(N)c4C#N)CC3)n2)ccc1F CHEMBL3972635 IC50 3.5 nM
CC(C)NC[C@@H](C(=O)N1CC2CCC(C1)N2c1ncnc2c1[C@H](C)CC(=O)N2)c1ccc(Cl)cc1 CHEMBL5177491 IC50 3.5 nM
Cc1n[nH]c2ccc(-c3cncc(OC[C@@H](N)Cc4ccc(Cl)c(F)c4)c3)cc12 CHEMBL229917 IC50 3.6 nM
N#Cc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C(F)(F)F)c3)cn2CCN)CC1 CHEMBL3899777 IC50 3.6 nM
Nc1ncnc(N2CCC(c3nc(-c4ccnc(C(F)(F)F)c4)cn3CCNC3CC3)CC2)c1Cl CHEMBL3931731 IC50 3.6 nM
NC1(c2ccc(-c3nc4n(c3-c3ccccc3)COc3cccc(F)c3-4)cc2)CC(O)(C2CC2)C1 CHEMBL3701717 IC50 3.7 nM
COc1ccc2c(c1)OCn1c-2nc(-c2ccc(C3(N)CC(O)(C4CC4)C3)cc2)c1-c1ccccc1 CHEMBL3701734 IC50 3.7 nM
NCc1ccc(-n2c(-c3cccnc3N)nc3ccc(-c4ccccc4)nc32)cc1 CHEMBL4513257 IC50 3.7 nM
Nc1ncccc1-c1nc2ccc(Nc3ccccc3)nc2n1-c1ccc(C2(N)CCC2)cc1 CHEMBL3640748 IC50 3.77 nM
Cn1ncc(Cl)c1-c1cc(C(=O)N[C@@H]2CN[C@H](CC(O)CO)C[C@H]2c2ccc(Cl)c(Cl)c2)oc1Cl CHEMBL4470606 IC50 3.79 nM
CSc1ncc2cc(-c3ccccc3)c(-c3ccc(CN4CCC(c5nnc(-c6ccccn6)[nH]5)CC4)cc3)nc2n1 CHEMBL254099 IC50 3.8 nM
NC1(C(=O)NCc2ccc(Cl)cc2Cl)CCN(c2ncnc3[nH]ccc23)CC1 CHEMBL599849 IC50 3.8 nM
O=C(Nc1csc(-c2nncn2C2CC2)n1)c1cc(-n2cnc(C3CC3)c2)c(N2CCCOCC2)cn1 CHEMBL3893943 IC50 3.8 nM
COc1ccc(-c2cc3c(C)nc(N)nc3n(C3CCC(OCCO)CC3)c2=O)cn1 CHEMBL5278357 IC50 3.8 nM
COc1ccc(C(=O)NNC(=O)c2cc3nc(-c4cnc(N)nc4)nc(N4CCOCC4)c3s2)cc1 CHEMBL5278435 IC50 3.8 nM
Cc1ccc(F)cc1C[C@H](N)COc1cncc(-c2ccc3[nH]nc(C)c3c2)c1 CHEMBL227368 IC50 3.9 nM
N[C@H](COc1cncc(-c2ccc3[nH]nc(-c4ccccc4)c3c2)c1)Cc1c[nH]c2ccccc12 CHEMBL574764 IC50 3.9 nM
Cc1ccc(F)cc1C[C@H](N)COc1cncc(-c2cc3c(C)n[nH]c3cn2)c1 CHEMBL573133 IC50 3.9 nM
NC1(c2ccc(-c3nc4n(c3-c3ccccc3)COc3ncccc3-4)cc2)CCC1 CHEMBL3701754 IC50 3.9 nM
NC1(c2ccc(-c3nc4n(c3-c3ccccc3)COc3ccccc3-4)cc2)CC(O)(C2CC2)C1 CHEMBL3701727 IC50 3.9 nM
Cn1ncc(Cl)c1-c1cc(C(=O)N[C@@H]2CN[C@H](CC(=O)NC3CC3)C[C@H]2c2ccc(Cl)c(Cl)c2)oc1Cl CHEMBL4589576 IC50 3.95 nM
COc1ccc(O)c(C(=O)c2ccc(C(=O)N[C@@H]3CCCNCC3NC(=O)c3ccncc3)cc2)c1F CHEMBL1202518 IC50 4.0 nM
CC1C(=O)Nc2ccc(N[C@H](COc3cncc(-c4ccc5c(c4)C(C)C(=O)N5)c3)Cc3c[nH]c4ccccc34)cc21 CHEMBL208761 IC50 4.0 nM
CSc1ncc2cc(-c3ccccc3)c(-c3ccc(CN4CCC(n5ncc6c(N)ncnc65)CC4)cc3)nc2n1 CHEMBL253693 IC50 4.0 nM
CCNCC(Cc1ccccc1)NC(=O)c1cc(Br)c(-c2ccnc3[nH]ccc23)s1 CHEMBL471059 IC50 4.0 nM
O=c1[nH]ccc2nc(-c3ccc(CN4CCC(c5nnc(-c6cnccn6)[nH]5)CC4)cc3)c(-c3ccccc3)cc12 CHEMBL444136 IC50 4.0 nM
Nc1ccc(-c2nnc(C3CCN(Cc4ccc(-c5nc6cc[nH]c(=O)c6cc5-c5ccccc5)cc4)CC3)[nH]2)cn1 CHEMBL502393 IC50 4.0 nM
CN(C)CCN1CCN(c2ncc3cc(-c4ccccc4)c(-c4ccc(CN5CCC(c6nnc(-c7ccccn7)[nH]6)CC5)cc4)nc3n2)CC1 CHEMBL443661 IC50 4.0 nM
c1ccc(-c2cc3c(ccn4cnnc34)nc2-c2ccc(CN3CCC(c4n[nH]c(-c5ccccn5)n4)CC3)cc2)cc1 CHEMBL447328 IC50 4.0 nM
CC1C(=O)Nc2ccc(-c3cncc(OC[C@@H](N)Cc4c[nH]c5ccccc45)c3)cc21 CHEMBL574262 IC50 4.0 nM
CC(C)(C)c1ccc(CC2(N)CCN(c3ncnc4[nH]ccc34)CC2)cc1 CHEMBL597211 GI50 4.0 nM
CCn1c(-c2nonc2N)nc2c(C#CC(C)(C)O)nc(CCN)cc21 CHEMBL1095624 IC50 4.0 nM
Clc1c[nH]c2ncnc(N3CCC4(CCNCC4)C3)c12 CHEMBL1173350 IC50 4.0 nM
CC1SCc2ncnc(N3CCN(C(=O)[C@H](N)Cc4ccc(Cl)cc4)CC3)c21 CHEMBL1632371 IC50 4.0 nM
C[C@@H]1SCc2ncnc(N3CCN(C(=O)[C@H](N)Cc4ccc(F)c(F)c4)CC3)c21 CHEMBL1632377 IC50 4.0 nM
Cc1cccc(C)c1S(=O)(=O)NC[C@@H](O)CN1CCC[C@@]2(CCN(c3ncnc(N)c3C3CC3)C2)C1 CHEMBL1760768 IC50 4.0 nM
CC(C)NC[C@@H](C(=O)N1CCN(c2ncnc3c2[C@H](C)C[C@H]3F)CC1)c1ccc(Cl)cc1 CHEMBL2177381 IC50 4.0 nM
NC1(C(=O)NC(CCO)c2ccc(Cl)cc2)CCN(c2ncnc3[nH]ccc23)CC1 CHEMBL2325738 IC50 4.0 nM
NC1(C(=O)N[C@@H](CCN2CCCCC2)c2ccc(Cl)cc2)CCN(c2ncnc3[nH]ccc23)CC1 CHEMBL2325729 IC50 4.0 nM
NC1(C(=O)N[C@@H](CCN2CCCC2)c2ccc(Cl)cc2)CCN(c2ncnc3[nH]ccc23)CC1 CHEMBL2325728 IC50 4.0 nM
NC1(C(=O)NC(CCCN2CCCC2)c2ccc(Cl)cc2)CCN(c2ncnc3[nH]ccc23)CC1 CHEMBL2325994 IC50 4.0 nM
C[C@H](NC(=O)C1(N)CCN(c2ncnc3[nH]ccc23)CC1)c1ccc(Cl)cc1 CHEMBL2325743 IC50 4.0 nM
c1ccc(-c2cn3ccnc3nc2-c2ccc(CN3CCC(c4cnc5ccccc5n4)CC3)cc2)cc1 CHEMBL3672012 IC50 4.0 nM
Cc1nc2nc(-c3ccc(CN4CC(c5n[nH]c(-c6ccccn6)n5)C4)cc3)c(-c3ccccc3)cn2c1Br CHEMBL3672027 IC50 4.0 nM
COC(=O)c1cccc(-c2cnc3cc(-c4ccccc4)c(-c4ccc(C5(N)CCC5)cc4)nn23)c1 CHEMBL3672483 IC50 4.0 nM
O=C(Cc1nc(N2CCOCC2)cc(=O)[nH]1)N1CCc2cc(F)c(F)cc21 CHEMBL3699804 IC50 4.0 nM
CC1Cc2c(F)cccc2N1C(=O)Cc1nc(N2CCOCC2)cc(=O)[nH]1 CHEMBL3965878 IC50 4.0 nM
CC(C)C1Cc2ccccc2N1C(=O)Cc1nc(N2CCOCC2)cc(=O)[nH]1 CHEMBL3918242 IC50 4.0 nM
C[C@H]1Cc2ccccc2N1C(=S)Cc1nc(N2CCOCC2)cc(=S)[nH]1 CHEMBL3971967 IC50 4.0 nM
CCO/C=C/c1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C(F)(F)F)c3)cn2CCN(C)C)CC1 CHEMBL3973987 IC50 4.0 nM
C[C@@H]1CC(=O)Nc2ncnc(N3CCC(c4nc(C5CCOCC5)cn4CCN4CCCC4)CC3)c21 CHEMBL4126067 IC50 4.0 nM
COc1ccc(O)c(C(=O)c2ccc(C(=O)N[C@@H]3CCCNC[C@H]3NC(=O)c3ccncc3)cc2)c1F CHEMBL4468352 IC50 4.0 nM
Cn1nccc1-c1ccc(C(=O)N[C@@H]2CNCC[C@H]2c2ccc(F)c(F)c2)c(F)c1 CHEMBL4556790 IC50 4.0 nM
CNC[C@@H](Nc1ncnc2c(C(N)=O)cccc12)c1cccc(F)c1 CHEMBL3685329 IC50 4.0 nM
NC(=O)c1cccc2c(N[C@H](CN3CCC3)c3ccc(F)c(F)c3)ncnc12 CHEMBL4860970 IC50 4.0 nM
NC(=O)c1cccc2c(N[C@H](CN3CCC3)c3ccc(Cl)c(C(F)(F)F)c3)ncnc12 CHEMBL4871106 IC50 4.0 nM
Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCCCCCCCC(=O)NCCNC[C@@H](C(=O)N2CCN(c3ncnc4c3[C@H](C)C[C@H]4O)CC2)c2ccc(Cl)cc2)C(C)(C)C)cc1 CHEMBL5078362 Kd 4.0 nM
CCOc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C(F)(F)F)c3)cn2CCN2CCC2)CC1 CHEMBL3932390 IC50 4.1 nM
CCc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C(F)(F)F)c3)cn2CCN2CCC2)CC1 CHEMBL3922798 IC50 4.1 nM
N#Cc1c(N)ncnc1N1CCC(c2nc(-c3ccc(OC(F)F)c(F)c3)cn2CCN2CCC2)CC1 CHEMBL3972741 IC50 4.1 nM
C[C@@H]1CC(=O)Nc2ncnc(N3CCN(C(=O)[C@H](CNC4C5COCC54)c4ccc(Cl)cc4)[C@@H]4C[C@@H]43)c21 CHEMBL5199199 IC50 4.1 nM
NC1(c2ccc(-n3c(-c4ccccc4)nc4ccc(Nc5ccccc5)nc43)cc2)CCC1 CHEMBL3649688 IC50 4.13 nM
CN(Cc1ccc(Cl)cc1)C(=O)C1(N)CCN(c2ncnc3[nH]ccc23)CC1 CHEMBL597803 IC50 4.2 nM
NC1(c2ccc(-c3nc4n(c3-c3ccccc3)COc3ccncc3-4)cc2)CC(O)(C2CC2)C1 CHEMBL5316198 IC50 4.2 nM
CCc1c(N)ncnc1N1CCC(c2nc(-c3ccnc(C(C)C)c3)cn2CCN2CCC2)CC1 CHEMBL3944209 IC50 4.2 nM
C=Cc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C(F)(F)F)c3)cn2CCN2CCC2)CC1 CHEMBL3931504 IC50 4.2 nM
Nc1ncnc(N2CCC(c3nc(-c4cccc(C(F)(F)F)c4)cn3CCN3CCCC3)CC2)c1Br CHEMBL3906488 IC50 4.2 nM
CN(C)C(=O)c1cccc(-c2ccc3nc(-c4ccccc4)n(-c4ccc(C5(N)CCC5)cc4)c3n2)c1 CHEMBL3649686 IC50 4.27 nM
Oc1nc2ccc(N[C@H](COc3cncc(-c4ccc5nc(O)sc5c4)c3)Cc3c[nH]c4ccccc34)cc2s1 CHEMBL209503 IC50 4.3 nM
N[C@H](COc1cncc(-c2ccc3[nH]c(=O)oc3c2)c1)Cc1c[nH]c2ccccc12 CHEMBL575824 IC50 4.3 nM
NC1(c2ccc(-n3c(-c4cccnc4)nc4ccc(-c5ccccc5)nc43)cc2)CCC1 CHEMBL3649672 IC50 4.3 nM
CCC(C)(C)NCCn1cc(-c2ccc(F)c(C(F)(F)F)c2)nc1C1CCN(c2ncnc(N)c2C#N)CC1 CHEMBL3891300 IC50 4.3 nM
O=C(N1CCN(c2ncnc3[nH]cc(Br)c23)CC1)C1(c2ccc(Cl)c(Cl)c2)CCNCC1 CHEMBL4207643 IC50 4.3 nM
Cn1nccc1-c1ccc2c(c1)CN([C@@H]1CNCC[C@H]1c1ccc(F)c(F)c1)C2=O CHEMBL5437703 IC50 4.3 nM
CC1(O)CC(N)(c2ccc(-c3nc4n(c3-c3ccccc3)COc3ccc(C#N)cc3-4)cc2)C1 CHEMBL3701761 IC50 4.4 nM
CN(C)C(=O)c1ccc2c(c1)-c1nc(-c3ccc(C4(N)CC(C)(O)C4)cc3)c(-c3ccccc3)n1CO2 CHEMBL3701768 IC50 4.4 nM
NC1(c2ccc(-n3c(-c4cccc(O)c4)nc4ccc(-c5cccc(N6CCOCC6)c5)nc43)cc2)CCC1 CHEMBL3649679 IC50 4.42 nM
Cn1ncc(Cl)c1-c1cc(C(=O)N[C@@H]2CN[C@H](CCn3cncn3)C[C@H]2c2ccc(Cl)c(Cl)c2)oc1Cl CHEMBL4519793 IC50 4.47 nM
CSc1ncc2cc(-c3ccccc3)c(-c3ccc(CN4CCC(c5cc(-c6ccncc6)[nH]n5)CC4)cc3)nc2n1 CHEMBL404554 IC50 4.5 nM
CC(C)Oc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C(F)(F)F)c3)cn2CC2CNC2)CC1 CHEMBL3925183 IC50 4.5 nM
Cc1cc(-c2cn(CC3CNC3)c(C3CCN(c4ncnc(N)c4C(C)C)CC3)n2)ccc1F CHEMBL3974201 IC50 4.5 nM
O=C(Nc1csc(-c2nncn2C2CC2)n1)c1cc(-n2cnc(C3CC3)c2)c(N2CC3(CCOCC3)C2)cn1 CHEMBL3973753 IC50 4.5 nM
N#Cc1ncc(OC[C@@H](N)Cc2c[nH]c3ccccc23)cc1-c1ccc2cnccc2c1 CHEMBL379209 IC50 4.6 nM
Cc1nnc2c3cc(-c4ccccc4)c(-c4ccc(CN5CCC(c6n[nH]c(-c7ccccn7)n6)CC5)cc4)nc3ccn12 CHEMBL445464 IC50 4.6 nM
CC1(O)CC(N)(c2ccc(-c3nc4n(c3-c3ccccc3)COc3cccc(F)c3-4)cc2)C1 CHEMBL3701718 IC50 4.6 nM
Cn1nccc1-c1ccc(C(=O)N[C@@H]2CNCC[C@H]2c2cc(F)cc(F)c2)c(F)c1 CHEMBL4866810 IC50 4.6 nM
CCOC(=O)c1c(C)nc(NNC(=O)c2cccc3c(=O)c4ccccc4[nH]c23)nc1-c1ccccc1 CHEMBL4163627 IC50 4.7 nM
COc1ccc(Cn2ncc(NC(=O)c3cc(NC(=O)Nc4ccc(Cl)c(C(F)(F)F)c4)ccc3C)c2N)cc1 CHEMBL1684800 IC50 4.72 nM
NC1(c2ccc(-n3c(-c4ccccc4O)nc4ccc(-c5ccccc5)nc43)cc2)CCC1 CHEMBL3649674 IC50 4.74 nM
COc1ccc(-c2nc3ccc(-c4cccc(N5CCOCC5)c4)nc3n2-c2ccc(C3(N)CCC3)cc2)cc1 CHEMBL3649680 IC50 4.78 nM
Cc1c[nH]c2ncnc(N3CC4(CCNCC4)c4ccccc43)c12 CHEMBL259163 IC50 4.8 nM
Clc1ccc2c(c1)C1(CCNCC1)CN2c1ncnc2[nH]ccc12 CHEMBL449964 IC50 4.8 nM
COc1cccc2c1-c1nc(-c3ccc(C4(N)CC(O)(C5CC5)C4)cc3)c(-c3ccccc3)n1CO2 CHEMBL3701732 IC50 4.8 nM
CN(C)CCn1cc(-c2ccc(F)c(C(F)(F)F)c2)nc1C1CCN(c2ncnc(N)c2C2CC2)CC1 CHEMBL3900512 IC50 4.8 nM
CCc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(OC)c3)cn2CCN2CCC2)CC1 CHEMBL3935483 IC50 4.8 nM
Cc1cc(-c2cn(CCN(C)C)c(C3CCN(c4ncnc(N)c4-c4cn[nH]c4)CC3)n2)ccc1F CHEMBL3957657 IC50 4.8 nM
NC1(C(=O)N[C@@H](CCN2CCN(C(=O)CCOCCOCCOCCOCCOCCNc3cccc4c3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)c2ccc(Cl)cc2)CCN(c2ncnc3[nH]ccc23)CC1 CHEMBL5069422 Kd 4.8 nM
N[C@H](CNc1ncc(-c2ccc3cnccc3c2)s1)Cc1ccc(C(F)(F)F)cc1 CHEMBL1081263 IC50 4.9 nM
CC(=O)Nc1nc2ccc(-c3cnc(Cl)c(NS(=O)(=O)c4ccccc4Cl)c3)cc2s1 CHEMBL1773730 IC50 4.9 nM
Nc1ncnc(N2CCC(c3nc(-c4ccc(F)c(Cl)c4)cn3CCN3CCCC3)CC2)c1C1CCC1 CHEMBL3952378 IC50 4.9 nM
NC1(c2ccc(-n3c(-c4ccnnc4)nc4ccc(-c5cccc(N6CCOCC6)c5)nc43)cc2)CCC1 CHEMBL3649685 IC50 4.96 nM
COc1ccc(O)c(C(=O)c2ccc(C(=O)O[C@@H]3CCCNCC3NC(=O)c3ccncc3)cc2)c1F CHEMBL3216643 IC50 5.0 nM
Cc1n[nH]c2ccc(-c3cncc(OC[C@@H](N)Cc4ccc(Br)cc4)c3)cc12 CHEMBL229855 IC50 5.0 nM
Cc1n[nH]c2cnc(-c3cncc(OC[C@@H](N)Cc4cccc(F)c4F)c3)cc12 CHEMBL427422 IC50 5.0 nM
CCn1c(-c2nonc2N)nc2c(C#CC(C)(C)O)ncc(OCCCNCCc3ccc(OC)cc3)c21 CHEMBL494060 IC50 5.0 nM
CC(=O)N1CCN(c2ncc3cc(-c4ccccc4)c(-c4ccc(CN5CCC(c6nnc(-c7ccccn7)[nH]6)CC5)cc4)nc3n2)CC1 CHEMBL453586 IC50 5.0 nM
c1ccc(-c2cc3cnc(-n4ccnc4)nc3nc2-c2ccc(CN3CCC(c4nnc(-c5ccccn5)[nH]4)CC3)cc2)cc1 CHEMBL448926 IC50 5.0 nM
c1ccc(-c2cc3cnc(N4CCOCC4)nc3nc2-c2ccc(CN3CCC(c4nnc(-c5ccccn5)[nH]4)CC3)cc2)cc1 CHEMBL488654 IC50 5.0 nM
Cc1n[nH]c2cnc(-c3cncc(OC[C@@H](N)Cc4ccc(Br)cc4)c3)cc12 CHEMBL573778 IC50 5.0 nM
CCn1c(-c2nonc2N)nc2c(C#CC(C)(C)O)nc(OCCN)cc21 CHEMBL1096291 IC50 5.0 nM
CCn1c(-c2nonc2N)nc2c(C#CC(C)(C)O)nc(OC[C@@H](N)c3ccccc3)cc21 CHEMBL1096626 IC50 5.0 nM
N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ncnc3[nH]ccc23)CC1 CHEMBL1258552 IC50 5.0 nM
NC[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ncnc3[nH]ccc23)CC1 CHEMBL1236822 IC50 5.0 nM
COc1ccc(S(=O)(=O)Nc2cc(-c3ccc4nc(NC(C)=O)sc4c3)cnc2Cl)cc1 CHEMBL1773604 IC50 5.0 nM
CC(=O)Nc1nc2ccc(-c3cnc(Cl)c(NS(=O)(=O)c4ccccc4)c3)cc2s1 CHEMBL1773605 IC50 5.0 nM
COC(=O)c1cc(NCCN2CCCC2)c(C)c(N2CCN(c3ncnc4[nH]nc(Br)c34)CC2)c1 CHEMBL2016891 IC50 5.0 nM
CCC(=O)c1cc(NCCN2CCCC2)c(C)c(N2CCN(c3ncnc4[nH]nc(Br)c34)CC2)c1 CHEMBL2016892 IC50 5.0 nM
CC(=O)Nc1cccc(-c2ccc3nc(-c4cccnc4N)n(-c4ccc(CNC(=O)c5cccc(F)c5)cc4)c3n2)c1 CHEMBL2177836 IC50 5.0 nM
CO[C@H]1CC[C@H](NC[C@@H](C(=O)N2CCN(c3ncnc4c3[C@H](C)C[C@H]4O)CC2)c2ccc(Cl)cc2)CC1 CHEMBL2177367 IC50 5.0 nM
C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(C(=O)[C@H](CNC4CCOCC4)c4ccc(Cl)cc4)CC3)c21 CHEMBL2177366 IC50 5.0 nM
C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(C(=O)[C@H](CNCC4CC4)c4ccc(Cl)cc4)CC3)c21 CHEMBL2177374 IC50 5.0 nM
NC1(C(=O)NC(CCCN2CCCCC2)c2ccc(Cl)cc2)CCN(c2ncnc3[nH]ccc23)CC1 CHEMBL2325996 IC50 5.0 nM
NC1(C(=O)NC(CCCN2CCOCC2)c2ccc(Cl)cc2)CCN(c2ncnc3[nH]ccc23)CC1 CHEMBL2325995 IC50 5.0 nM
NC1(C(=O)NC(c2ccc(Cl)cc2)C2CC2)CCN(c2ncnc3[nH]ccc23)CC1 CHEMBL2325983 IC50 5.0 nM
CC1(O)CC(O)(c2ccc(-c3nc4n(c3-c3ccccc3)COc3ccc(C(=O)O)cc3-4)cc2)C1 CHEMBL3701777 IC50 5.0 nM
C[C@H]1Cc2ccccc2N1C(=O)Cc1nc(N2CCOCC2)cc(=O)[nH]1 CHEMBL3112866 IC50 5.0 nM
CCc1cnn2cc(-c3ccccc3)c(-c3ccc(CN4CC(c5n[nH]c(-c6cccc(C)n6)n5)C4)cc3)nc12 CHEMBL3672042 IC50 5.0 nM
COC(=O)c1cnn2cc(-c3c(F)cccc3F)c(-c3ccc(CN4CCC(c5n[nH]c(-c6ccccn6)n5)CC4)cc3)nc12 CHEMBL3672051 IC50 5.0 nM
CSc1nc2nc(-c3ccc(CN4CC(c5n[nH]c(-c6cccc(C)n6)n5)C4)cc3)c(-c3ccccc3)cn2n1 CHEMBL3672083 IC50 5.0 nM
CSc1nc2nc(-c3ccc(CN4CC(c5n[nH]c(-c6ccccn6)n5)C4)cc3)c(-c3ccccc3)cn2n1 CHEMBL3672084 IC50 5.0 nM
CSc1nc2nc(-c3ccc(CN4CCC(c5n[nH]c(-c6cccc(C)n6)n5)CC4)cc3)c(-c3ccccc3)cn2n1 CHEMBL3672088 IC50 5.0 nM
NC1(c2ccc(-c3nc4c(Br)cc(Cl)cn4c3-c3ccccc3)cc2)CCC1 CHEMBL3699759 IC50 5.0 nM
N#Cc1cccc(-c2cnc3cc(-c4ccccc4)c(-c4ccc(C5(N)CCC5)cc4)nn23)c1 CHEMBL3672480 IC50 5.0 nM
COc1cncc(-c2cnc3cc(-c4ccccc4)c(-c4ccc(C5(N)CCC5)cc4)nn23)c1 CHEMBL3672499 IC50 5.0 nM
O=C(Cc1nc(N2CCOCC2)cc(=O)[nH]1)N1CCc2c(F)cccc21 CHEMBL3112848 IC50 5.0 nM
O=C(Cc1nc(N2CCOCC2)cc(=O)[nH]1)N1c2ccccc2CC1c1ccccc1 CHEMBL3945090 IC50 5.0 nM
O=C(Cc1nc(N2CCOCC2)cc(=O)[nH]1)N1c2ccccc2CC1C1CC1 CHEMBL3964685 IC50 5.0 nM
CCOc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C(F)(F)F)c3)cn2CC2CNC2)CC1 CHEMBL3900660 IC50 5.0 nM
C[C@@H]1CC(=O)Nc2ncnc(N3CCC(c4nc(CCC(F)(F)F)cn4CCN4CCCC4)CC3)c21 CHEMBL4129379 IC50 5.0 nM
NC1(c2ccc(-c3nc4ccn5c(=O)[nH]nc5c4cc3-c3ccccc3)cc2)CCC1 CHEMBL1079175 IC50 5.0 nM
Cn1ncc(Cl)c1-c1ccc(C(=O)N[C@@H]2CNCC[C@H]2c2ccc(F)c(F)c2)cc1 CHEMBL4574492 IC50 5.0 nM
Cn1ncc(Cl)c1-c1coc(C(=O)N[C@@H]2CNCC[C@H]2c2ccc(F)c(F)c2)c1 CHEMBL4529738 IC50 5.1 nM
Nc1ncccc1-c1nc2cc(-c3cccnc3)cnc2n1-c1ccc(CNC(=O)c2cccc(F)c2)cc1 CHEMBL2177833 IC50 5.2 nM
COc1ncc(-c2cc3c(C)nc(N)nc3n([C@H]3CC[C@H](OCO)CC3)c2=O)cc1F CHEMBL2375968 IC50 5.24 nM
c1ccc2c(c1)N(c1ncnc3[nH]ccc13)CC21CCNCC1 CHEMBL259265 IC50 5.3 nM
CC1(O)CC(N)(c2ccc(-c3nc4n(c3-c3ccccc3)COc3ccccc3-4)cc2)C1 CHEMBL3701728 IC50 5.3 nM
c1ccc2c(C[C@@H](COc3cncc(-c4cc5ccncc5s4)c3)Nc3cc4ccncc4s3)c[nH]c2c1 CHEMBL211281 IC50 5.4 nM
N[C@H](COc1cncc(-c2ccc3c(c2)C(=O)C(=O)N3)c1)Cc1c[nH]c2ccccc12 CHEMBL574268 IC50 5.4 nM
NC1(c2ccc(-c3nc4n(c3-c3ccccc3)COc3nccnc3-4)cc2)CC(O)(C2CC2)C1 CHEMBL3701755 IC50 5.4 nM
CC(C)NCCn1cc(-c2ccc(F)c(C(F)(F)F)c2)nc1C1CCN(c2ncnc(N)c2C#N)CC1 CHEMBL3924599 IC50 5.4 nM
CC(C)(N)c1ccc(-n2c(-c3cccnc3N)nc3ccc(-c4ccccc4)nc32)cc1 CHEMBL4528363 IC50 5.4 nM
Cn1ncc(Br)c1-c1ccc(C(=O)N[C@@H]2CNCC[C@H]2c2cccc(F)c2)s1 CHEMBL4444441 IC50 5.46 nM
Cc1n[nH]c2ccc(-c3nnc(NC[C@@H](N)Cc4ccc(C(F)(F)F)cc4)s3)cc12 CHEMBL1080911 IC50 5.5 nM
COc1ccc2c(n1)-c1nc(-c3ccc(C4(N)CC(C)(O)C4)cc3)c(-c3ccccc3)n1CO2 CHEMBL3701765 IC50 5.5 nM
NC1(c2ccc(-c3nc4n(c3-c3ccccc3)COc3cnccc3-4)cc2)CCC1 CHEMBL3701751 IC50 5.5 nM
Cc1cc(-c2cn(CCN3CCC3)c(C3CCN(c4ncnc(N)c4-c4cn[nH]c4)CC3)n2)ccc1F CHEMBL3922949 IC50 5.5 nM
Cc1cc(-c2cn(CCNC(C)(C)C)c(C3CCN(c4ncnc(N)c4-c4cn[nH]c4)CC3)n2)ccc1F CHEMBL3970663 IC50 5.5 nM
CN1C(=O)CCC(N2C(=O)c3cccc(NCCOCCOCCOCCOCCOCCC(=O)N4CCN(CC[C@H](NC(=O)C5(N)CCN(c6ncnc7[nH]ccc67)CC5)c5ccc(Cl)cc5)CC4)c3C2=O)C1=O CHEMBL5089002 Kd 5.5 nM
Cc1n[nH]c2ccc(-c3cncc(OC[C@@H](N)Cc4cccc(Cl)c4Cl)c3)cc12 CHEMBL229918 IC50 5.6 nM
c1ccc(-c2cc3ncccc3nc2-c2ccc(CN3CCC(c4n[nH]c(-c5ccccn5)n4)CC3)cc2)cc1 CHEMBL259753 IC50 5.6 nM
Cc1cc(-c2cn(CCNC3CCCC3)c(C3CCN(c4ncnc(N)c4C(N)=O)CC3)n2)ccc1F CHEMBL3934916 IC50 5.6 nM
O=C(N1CCN(c2ncnc3[nH]cc(Cl)c23)CC1)C1(c2cccc(Br)c2)CCNCC1 CHEMBL4217723 IC50 5.6 nM
Cn1ncc(Cl)c1-c1cc(C(=O)N[C@@H]2CN[C@H](CCN3CCCCC3)C[C@H]2c2ccc(Cl)c(Cl)c2)oc1Cl CHEMBL4524940 IC50 5.65 nM
Nc1ccccc1-c1nc2ccc(-c3ccccc3)nc2n1-c1ccc(C2(N)CCC2)cc1 CHEMBL3649676 IC50 5.67 nM
Cc1ccc(-c2nc3c(C)nc(N)nc3n([C@H]3CC[C@H](O)CC3)c2=O)cn1 CHEMBL1257295 IC50 5.7 nM
NC1(c2ccc(-n3c(-c4ncccn4)nc4ccc(-c5cccc(N6CCOCC6)c5)nc43)cc2)CCC1 CHEMBL3649684 IC50 5.71 nM
Cc1ccc(-c2nc3c(C)nc(N)nc3n([C@H]3CC[C@H](OCCO)CC3)c2=O)cn1 CHEMBL1258910 IC50 5.74 nM
Cn1cc(-c2nc3ccc(-c4ccccc4)nc3n2-c2ccc(C3(N)CCC3)cc2)c(N)n1 CHEMBL3649670 IC50 5.78 nM
Clc1c[nH]c2ncnc(N3CC4(CCNCC4)c4ccccc43)c12 CHEMBL411515 IC50 5.8 nM
COc1ncc(-c2cc3c(C)nc(N)nc3n([C@H]3CC[C@H](OCC(N)=O)CC3)c2=O)cc1F CHEMBL2375957 IC50 5.82 nM
CC(C)(Cc1ccccc1)C1C(=O)Nc2ccc(-c3cncc(OC[C@@H](N)Cc4c[nH]c5ccccc45)c3)cc21 CHEMBL210034 IC50 5.9 nM
Cc1n[nH]c2ccc(-c3cncc(OC[C@@H](N)Cc4cccc(Cl)c4)c3)cc12 CHEMBL229799 IC50 5.9 nM
N[C@H](COc1cncc(-c2ccc3c(c2)C(c2ccccc2)C(=O)N3)c1)Cc1c[nH]c2ccccc12 CHEMBL577379 IC50 5.9 nM
NC1(c2ccc(-n3c(-c4cccc(Cl)c4)nc4ccc(-c5cccc(N6CCOCC6)c5)nc43)cc2)CCC1 CHEMBL3649682 IC50 5.9 nM
Nc1ncnc(N2CCC(c3nc(-c4cccc(F)c4)cn3CCN3CCCC3)CC2)c1Br CHEMBL3949523 IC50 5.9 nM
Cn1ncc(Cl)c1-c1cc(C(=O)N[C@@H]2CN[C@H](CCN3CCC(O)CC3)C[C@H]2c2ccc(Cl)c(Cl)c2)oc1Cl CHEMBL4518523 IC50 5.99 nM
CNc1nccc(-c2ccc(C(=O)N[C@H](CN)Cc3ccc(Cl)cc3Cl)s2)n1 CHEMBL213618 IC50 6.0 nM
Cc1cc(F)ccc1C[C@H](N)COc1cncc(-c2ccc3[nH]nc(C)c3c2)c1 CHEMBL376394 IC50 6.0 nM
CNc1ncc2cc(-c3ccccc3)c(-c3ccc(CN4CCC(c5nnc(-c6ccccn6)[nH]5)CC4)cc3)nc2n1 CHEMBL252857 IC50 6.0 nM
CCn1c(-c2nonc2N)nc2c(C#CC(C)(C)O)ncc(OCCCN)c21 CHEMBL493874 IC50 6.0 nM
NCC(NC(=O)c1ccc(-c2ccnc3[nH]ccc23)s1)c1ccccc1 CHEMBL471034 IC50 6.0 nM
NCC(NC(=O)c1cc(C2CC2)c(-c2ccnc3[nH]ccc23)s1)c1ccccc1 CHEMBL512858 IC50 6.0 nM
CN1CC(N2CCN(c3ncc4cc(-c5ccccc5)c(-c5ccc(CN6CCC(c7nnc(-c8ccccn8)[nH]7)CC6)cc5)nc4n3)CC2)C1 CHEMBL448991 IC50 6.0 nM
Cc1cc(F)ccc1C[C@H](N)COc1cncc(-c2cc3c(C)n[nH]c3cn2)c1 CHEMBL575427 IC50 6.0 nM
Cc1occc1-c1nc(N)c(OC[C@@H](N)Cc2ccccc2)cc1-c1cnc2[nH]nc(C)c2n1 CHEMBL594755 IC50 6.0 nM
N[C@H](CNc1nnc(-c2ccc3[nH]ncc3c2)s1)Cc1ccc(C(F)(F)F)cc1 CHEMBL1081628 IC50 6.0 nM
CCn1c(-c2nonc2N)nc2c(C#CC(C)(C)O)nc(CN3CCCC3)cc21 CHEMBL1096290 IC50 6.0 nM
CCn1c(-c2nonc2N)nc2c(C#CC(C)(C)O)nc(CN)cc21 CHEMBL1098241 IC50 6.0 nM
C[C@@H]1SCc2ncnc(N3CCN(C(=O)C(Cc4ccc(Cl)cc4)CC(C)(C)N)CC3)c21 CHEMBL1632387 IC50 6.0 nM
CC(C)NCC(Cc1ccc(Cl)c(F)c1)C(=O)N1CCN(c2ncnc3c2[C@H](C)OC3)CC1 CHEMBL1632390 IC50 6.0 nM
Cc1noc(-c2cc(NCCN3CCCC3)c(C)c(N3CCN(c4ncnc5[nH]nc(Br)c45)CC3)c2)n1 CHEMBL2016890 IC50 6.0 nM
C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(C(=O)[C@H](CNC(C)(C)CO)c4ccc(C(F)(F)F)c(F)c4)CC3)c21 CHEMBL2178598 IC50 6.0 nM
C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(C(=O)[C@H](CN4CCC(F)CC4)c4ccc(Cl)cc4)CC3)c21 CHEMBL2177363 IC50 6.0 nM
CC(C)NC[C@@H](C(=O)N1CCN(c2ncnc3c2[C@H](C)CC3)CC1)c1ccc(Cl)cc1 CHEMBL2177385 IC50 6.0 nM
NC1(C(=O)NC(CCCO)c2ccc(Cl)cc2)CCN(c2ncnc3[nH]ccc23)CC1 CHEMBL2325739 IC50 6.0 nM
NC1(C(=O)NC(CCS(N)(=O)=O)c2ccc(Cl)cc2)CCN(c2ncnc3[nH]ccc23)CC1 CHEMBL2325734 IC50 6.0 nM
COc1ccc2c(c1)OCn1c-2nc(-c2ccc(C3(N)CC(C)(O)C3)cc2)c1-c1ccccc1 CHEMBL3701736 IC50 6.0 nM
Clc1cnc2nc(-c3ccc(CN4CC(c5nnc(-c6ccccn6)[nH]5)C4)cc3)c(-c3ccccc3)cn12 CHEMBL3667044 IC50 6.0 nM
Brc1cnc2nc(-c3ccc(CN4CC(c5n[nH]c(-c6ccccn6)n5)C4)cc3)c(-c3ccccc3)cn12 CHEMBL3672066 IC50 6.0 nM
Cc1cccc(-c2nc(C3CN(Cc4ccc(-c5nc6nc(C)c(Br)n6cc5-c5ccccc5)cc4)C3)n[nH]2)n1 CHEMBL3672068 IC50 6.0 nM
NC1(c2ccc(-c3nn4c(-c5cccc(CO)c5)cnc4cc3-c3ccccc3)cc2)CCC1 CHEMBL3672486 IC50 6.0 nM
Cc1cc(-c2ccc3nn4cc(-c5ccccc5)c(-c5ccc(C6(N)CCC6)cc5)nc4c3c2)[nH]n1 CHEMBL3672557 IC50 6.0 nM
CC1Cc2ccccc2N1C(=O)Cc1nc(N2CCOCC2)cc(=O)[nH]1 CHEMBL3112862 IC50 6.0 nM
CC1CN(c2cc(=O)[nH]c(CC(=O)Nc3ccc(F)cc3)n2)CCO1 CHEMBL3935564 IC50 6.0 nM
Nc1ncccc1-c1nc2ccc(-c3cccnc3)nc2n1-c1ccc(C2(N)CCC2)cc1 CHEMBL4544109 IC50 6.0 nM
NC(=O)c1cccc2c(N[C@H](CN3CCC3)c3cccc(C(F)(F)F)c3)ncnc12 CHEMBL4876446 IC50 6.0 nM
NC(=O)c1cccc2c(N[C@H](CN3CCC3)c3ccc(F)c(C(F)(F)F)c3)ncnc12 CHEMBL4846712 IC50 6.0 nM
CC(C)NC[C@@H](C(=O)N1CCN(c2ncnc3c2C(C)OC(=O)N3)CC1)c1ccc(Cl)cc1 CHEMBL5192188 IC50 6.0 nM
N[C@H](COc1cncc(-c2cc3c(-c4ccco4)n[nH]c3cn2)c1)Cc1ccccc1 CHEMBL375485 IC50 6.1 nM
Cc1n[nH]c2ccc(-c3nnc(NC[C@@H](N)Cc4cccc(C(F)(F)F)c4)s3)cc12 CHEMBL1080561 IC50 6.1 nM
N=C(N)n1c(=N)ccc2nc(-c3ccc(C4(N)CCC4)cc3)c(-c3ccccc3)cc21 CHEMBL3679629 IC50 6.1 nM
COc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C(F)(F)F)c3)cn2CCN2CCC2)CC1 CHEMBL3954017 IC50 6.1 nM
NC(=O)c1ncc2cc(-c3ccccc3)c(-c3ccc(CN4CCC(c5nnc(-c6ccccn6)[nH]5)CC4)cc3)nc2n1 CHEMBL404556 IC50 6.2 nM
CC1(O)CC(N)(c2ccc(-c3nc4n(c3-c3ccccc3)COc3cc(C#N)ccc3-4)cc2)C1 CHEMBL3701760 IC50 6.2 nM
Nc1ncnc(N2CCC(c3nc(-c4cccc(Cl)c4)cn3CCN3CCCC3)CC2)c1C1CCC1 CHEMBL3957616 IC50 6.2 nM
NC1(c2ccc(-n3c(-c4ccc(Cl)cc4)nc4ccc(-c5cccc(N6CCOCC6)c5)nc43)cc2)CCC1 CHEMBL3649683 IC50 6.27 nM
CC(=O)Nc1nc2ccc(-c3cnc(Cl)c(NS(=O)(=O)c4ccc(F)cc4)c3)cc2s1 CHEMBL1615189 IC50 6.3 nM
CCN(CCn1cc(-c2ccc(F)c(C)c2)nc1C1CCN(c2ncnc(N)c2OC(C)C)CC1)C(C)C CHEMBL3904672 IC50 6.3 nM
O=C(N[C@@H]1CNCC[C@H]1c1ccc(F)c(F)c1)c1cc2c(s1)OCCn1nccc1-2 CHEMBL5395510 IC50 6.3 nM
NC(COc1cncc(-c2ccc3[nH]c(=O)oc3c2)c1)Cc1c[nH]c2ccccc12 CHEMBL1987679 pKi 6.31 nM
CC1(O)CC(N)(c2ccc(-c3nc4n(c3-c3ccccc3)COc3ccc(F)cc3-4)cc2)C1 CHEMBL3701724 IC50 6.4 nM
CC1(O)CC(N)(c2ccc(-c3nc4n(c3-c3ccccc3)COc3nccnc3-4)cc2)C1 CHEMBL3701756 IC50 6.4 nM
Cc1cc(-c2cn(CC3CNC3)c(C3CCN(c4ncnc(N)c4OC(C)C)CC3)n2)ccc1F CHEMBL3987123 IC50 6.4 nM
Cn1ncc(Cl)c1-c1cc(C(=O)NC2CNCCC2c2ccc(F)c(F)c2)oc1Cl CHEMBL4465572 IC50 6.4 nM
Cn1ncc(Cl)c1-c1cc(C(=O)N[C@@H]2CN[C@H](CCN3CCCC3)C[C@H]2c2ccc(Cl)c(Cl)c2)oc1Cl CHEMBL4546392 IC50 6.41 nM
O=Nc1c(O)[nH]c2ccc(N[C@H](COc3cncc(-c4ccc5[nH]c(O)c(N=O)c5c4)c3)Cc3c[nH]c4ccccc34)cc12 CHEMBL376959 IC50 6.5 nM
CC(C)(C)c1ccc(CC2(N)CCN(c3ccnc4[nH]ncc34)CC2)cc1 CHEMBL603675 IC50 6.5 nM
Cc1n[nH]c2ccc(-c3cncc(OC[C@@H](N)Cc4csc5ccccc45)c3)cc12 CHEMBL263510 Ki 6.6 nM
CC1(O)CC(N)(c2ccc(-c3nc4n(c3-c3ccccc3)COc3ccncc3-4)cc2)C1 CHEMBL3701747 IC50 6.6 nM
Nc1ncnc(N2CCC(c3nc(-c4ccc(F)c(C(F)(F)F)c4)cn3CCN3CCC3)CC2)c1OCC(F)(F)F CHEMBL3895450 IC50 6.6 nM
CC(C)c1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C(F)(F)F)c3)cn2CCN2CCC2)CC1 CHEMBL3917410 IC50 6.6 nM
CCc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C(F)(F)F)c3)cn2CCN)CC1 CHEMBL3968744 IC50 6.6 nM
CCOc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C)c3)cn2CC2CNC2)CC1 CHEMBL3943569 IC50 6.6 nM
CCc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C)c3)cn2CCN2CCCC2)CC1 CHEMBL3975180 IC50 6.6 nM
CCOc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C)c3)cn2CCN2CCCC2)CC1 CHEMBL3900809 IC50 6.6 nM
NC1(Cc2c(Cl)cccc2Cl)CCN(c2ncnc3[nH]ccc23)CC1 CHEMBL597415 GI50 6.7 nM
N[C@H](COc1cncc(-c2ccc3cnccc3c2)c1)Cc1n[nH]c2ccccc12 CHEMBL211827 Ki 6.8 nM
Cc1n[nH]c2ccc(-c3cncc(OC[C@@H](N)Cc4cccc(OCC5CCNCC5)c4)c3)cc12 CHEMBL226745 IC50 6.8 nM
Cc1n[nH]c2cnc(-c3cncc(OC[C@@H](N)Cc4cccc(OCC5CCNCC5)c4)c3)cc12 CHEMBL576372 IC50 6.8 nM
C=Cc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C(F)(F)F)c3)cn2CCN2CCCC2)CC1 CHEMBL3932421 IC50 6.8 nM
C[C@@H]1CC(=O)Nc2ncnc(N3CCN(C(=O)[C@H](CN)c4ccc(Cl)cc4)[C@@H]4C[C@@H]43)c21 CHEMBL5187508 IC50 6.8 nM
Nc1ncnc(N2CCC(c3nc(-c4ccc(F)c(C(F)(F)F)c4)cn3CCN3CCC3)CC2)c1-c1cn[nH]c1 CHEMBL3927188 IC50 6.9 nM
O=c1[nH]ccc2nc(-c3ccc(CN4CCC(c5nnc(-c6ncccn6)[nH]5)CC4)cc3)c(-c3ccccc3)cc12 CHEMBL447114 IC50 7.0 nM
CS(=O)(=O)N1CCN(c2ncc3cc(-c4ccccc4)c(-c4ccc(CN5CCC(c6nnc(-c7ccccn7)[nH]6)CC5)cc4)nc3n2)CC1 CHEMBL502426 IC50 7.0 nM
OC1CCN(c2ncc3cc(-c4ccccc4)c(-c4ccc(CN5CCC(c6nnc(-c7ccccn7)[nH]6)CC5)cc4)nc3n2)CC1 CHEMBL500993 IC50 7.0 nM
CCC1SCc2ncnc(N3CCN(C(=O)[C@H](N)Cc4ccc(Cl)cc4)CC3)c21 CHEMBL1632372 IC50 7.0 nM
C[C@@H]1OCc2ncnc(N3CCN(C(=O)[C@H](N)Cc4ccc(Cl)cc4)CC3)c21 CHEMBL1632378 IC50 7.0 nM
C[C@@H]1SCc2ncnc(N3CCN(C(=O)C(Cc4ccc(Cl)c(F)c4)CC(C)(C)N)CC3)c21 CHEMBL1632388 IC50 7.0 nM
CC(=O)Nc1nc2ccc(-c3cnc(Cl)c(NS(=O)(=O)c4ccc(C(C)(C)C)cc4)c3)cc2s1 CHEMBL1773734 IC50 7.0 nM
O=C(N[C@@H](c1ccc(Cl)c(Cl)c1)C1CNC1)c1ccc2cnccc2c1 CHEMBL1823655 IC50 7.0 nM
CN1CC([C@@H](NC(=O)c2ccc3cnccc3c2)c2ccc(Cl)c(Cl)c2)C1 CHEMBL1823663 IC50 7.0 nM
Cc1c(NCCN2CCCC2)cc(CCC(C)(C)C)cc1N1CCN(c2ncnc3[nH]nc(Br)c23)CC1 CHEMBL2016889 IC50 7.0 nM
NC1(C(=O)NC(CO)c2ccc(Cl)cc2)CCN(c2ncnc3[nH]ccc23)CC1 CHEMBL2325737 IC50 7.0 nM
CS(=O)(=O)NCCC(NC(=O)C1(N)CCN(c2ncnc3[nH]ccc23)CC1)c1ccc(Cl)cc1 CHEMBL2325736 IC50 7.0 nM
CCC(NC(=O)C1(N)CCN(c2ncnc3[nH]ccc23)CC1)c1ccc(Cl)cc1 CHEMBL2325982 IC50 7.0 nM
Cc1cccc(-c2nc(C3CN(Cc4ccc(-c5nc6ncc(C)n6cc5-c5ccccc5)cc4)C3)n[nH]2)n1 CHEMBL3672026 IC50 7.0 nM
COC(=O)c1cnn2cc(-c3ccc(F)cc3F)c(-c3ccc(CN4CC(c5n[nH]c(-c6ccccn6)n5)C4)cc3)nc12 CHEMBL3672033 IC50 7.0 nM
Cc1nc2nc(-c3ccc(CN4CC(c5n[nH]c(-c6ccccn6)n5)C4)cc3)c(-c3ccccc3)c(C)n2n1 CHEMBL3672045 IC50 7.0 nM
COC(=O)c1cnn2cc(-c3c(F)cccc3F)c(-c3ccc(CN4CCC(c5n[nH]c(-c6cccc(C)n6)n5)CC4)cc3)nc12 CHEMBL3672050 IC50 7.0 nM
c1ccc(-c2cn3nc(C4CC4)nc3nc2-c2ccc(CN3CC(c4n[nH]c(-c5ccccn5)n4)C3)cc2)cc1 CHEMBL3639709 IC50 7.0 nM
CSc1nc2nc(-c3ccc(CN4CCC(c5n[nH]c(-c6ccccn6)n5)CC4)cc3)c(-c3ccccc3)cn2n1 CHEMBL3672085 IC50 7.0 nM
NC1(c2ccc(-c3nc4c(Cl)cc(Cl)cn4c3-c3ccccc3)cc2)CCC1 CHEMBL3699754 IC50 7.0 nM
CCOC(=O)c1cncc(-c2cnc3cc(-c4ccccc4)c(-c4ccc(C5(N)CCC5)cc4)nn23)c1 CHEMBL3672498 IC50 7.0 nM
O=C(Cc1nc(N2CCOCC2)cc(=O)[nH]1)N1CCc2cc(F)ccc21 CHEMBL3112847 IC50 7.0 nM
COCC[C@@H]1C[C@@H](c2ccc(Cl)c(Cl)c2)[C@H](NC(=O)c2cc(-c3c(Cl)cnn3C)c(Cl)o2)CN1 CHEMBL4568343 IC50 7.01 nM
Nc1cc2[nH]nc(Cl)c2cc1-c1cncc(OC[C@@H](N)Cc2c[nH]c3ccccc23)c1 CHEMBL225789 IC50 7.1 nM
NC1(c2ccc(-c3nc4n(c3-c3ccsc3)COc3cccc(F)c3-4)cc2)CC(O)(C2CC2)C1 CHEMBL3701720 IC50 7.1 nM
Cc1cc(-c2cn(CC3CNC3)c(C3CCN(c4ncnc(N)c4OCC(F)(F)F)CC3)n2)ccc1F CHEMBL3976254 IC50 7.1 nM
Nc1ncnc(Cl)c1-c1nc2ccc(-c3ccccc3)nc2n1-c1ccc(C2(N)CCC2)cc1 CHEMBL3649669 IC50 7.17 nM
CC(C)(Cc1ncc[nH]1)C1C(=O)Nc2ccc(-c3cncc(OC[C@@H](N)Cc4c[nH]c5ccccc45)c3)cc21 CHEMBL210209 IC50 7.2 nM
N[C@H](COc1cncc(-c2cc3cn[nH]c3cn2)c1)Cc1cccc(C(F)(F)F)c1 CHEMBL226850 IC50 7.2 nM
N[C@H](COc1cncc(-c2ccc3c(c2)C(c2ncc[nH]2)C(=O)N3)c1)Cc1c[nH]c2ccccc12 CHEMBL579053 IC50 7.2 nM
NC1(C(=O)NCc2ccc(Cl)cc2)CCN(c2ccnc3[nH]ccc23)CC1 CHEMBL599448 IC50 7.2 nM
Cn1ncc(Cl)c1-c1cc(C(=O)NC2CNCCC2c2ccc(C(F)(F)F)cc2)oc1Cl CHEMBL4536780 IC50 7.2 nM
NC1(c2ccc(-n3c(-c4cccnc4F)nc4ccc(-c5ccccc5)nc43)cc2)CCC1 CHEMBL3649675 IC50 7.27 nM
Nc1ncnc(N2CCC(c3nc(-c4ccc(C(F)(F)F)c(F)c4)cn3CCN3CCC3)CC2)c1C1CCC1 CHEMBL3948660 IC50 7.3 nM
CCOC1CN(c2cc(N)ncn2)CCC1c1nc(-c2ccc(F)c(C)c2)cn1CCN(CC)C(C)C CHEMBL3975500 IC50 7.3 nM
Oc1nc2ccc(N[C@H](COc3cncc(-c4ccc5nc(O)oc5c4)c3)Cc3c[nH]c4ccccc34)cc2o1 CHEMBL209281 IC50 7.4 nM
c1ccc(-c2cc3cnccc3nc2-c2ccc(CN3CCC(c4n[nH]c(-c5ccccn5)n4)CC3)cc2)cc1 CHEMBL259967 IC50 7.4 nM
N[C@H](COc1cncc(-c2cnc3c(c2)CC(=O)N3)c1)Cc1c[nH]c2ccccc12 CHEMBL575385 IC50 7.4 nM
Cc1c[nH]c2ncnc(N3CCC(N)(CNC(=O)c4ccc(F)cc4)C3)c12 CHEMBL1171673 IC50 7.4 nM
NC(=O)c1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(Cl)c3)cn2CCN2CCC2)CC1 CHEMBL3962020 IC50 7.5 nM
CCc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C(F)(F)F)c3)cn2CCN2CCCC2)CC1 CHEMBL3927440 IC50 7.6 nM
CC(C)Oc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C(F)(F)F)c3)cn2CCN(C)C)CC1 CHEMBL3905494 IC50 7.6 nM
N#Cc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(F)c3)cn2CCN2CCCC2)CC1 CHEMBL3890225 IC50 7.6 nM
N#Cc1c(N)ncnc1N1CCC(c2nc(-c3cccc(C(F)(F)F)c3)cn2CCN2CCCC2)CC1 CHEMBL3896892 IC50 7.6 nM
O=C(N1CCN(c2ncnc3[nH]cc(Br)c23)CC1)C1(c2cccc(Br)c2)CCNCC1 CHEMBL4212000 IC50 7.6 nM
COc1ccc(F)cc1C[C@H](N)COc1cncc(-c2ccc3[nH]nc(C)c3c2)c1 CHEMBL226577 IC50 7.7 nM
N#Cc1c[nH]c2ncnc(N3CC[C@](N)(CNC(=O)c4ccc(F)cc4F)C3)c12 CHEMBL1170447 IC50 7.7 nM
Nc1ncnc(N2CCN(C(=O)C(N)Cc3ccc(Cl)cc3)CC2)c1Br CHEMBL3127379 IC50 7.7 nM
CCc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C(F)(F)F)c3)cn2CCN2CC(C)C2)CC1 CHEMBL3963881 IC50 7.7 nM
NC1(c2ccc(-n3c(-c4ccccc4)nc4ccc(-c5ccccc5)nc43)cc2)CCC1 CHEMBL3649673 IC50 7.75 nM
N#Cc1c[nH]c2ncnc(N3CC[C@](N)(CNC(=O)c4ccc(F)cc4)C3)c12 CHEMBL1171993 IC50 7.8 nM
C=Cc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C(F)(F)F)c3)cn2CCN(C)C)CC1 CHEMBL3931848 IC50 7.9 nM
CC(C)Oc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C(F)(F)F)c3)cn2CCN2CCC2)CC1 CHEMBL3904712 IC50 7.9 nM
Cn1ncc(Cl)c1-c1cc(C(=O)N[C@@H]2CN[C@H](CC(=O)NC3CCC3)C[C@H]2c2ccc(Cl)c(Cl)c2)oc1Cl CHEMBL4447158 IC50 7.98 nM
CCn1c(-c2nonc2N)nc2c(C#CC(C)(C)O)ncc(OC3CCNCC3)c21 CHEMBL1794066 IC50 8.0 nM
CCn1c(-c2nonc2N)nc2c(C#CC(C)(C)O)ncc(OCC3CCNC3)c21 CHEMBL494088 IC50 8.0 nM
NCC(NC(=O)c1cc(Br)c(-c2ccnc3[nH]ccc23)s1)c1ccccc1 CHEMBL512135 IC50 8.0 nM
Cc1cc(C(=O)NC(CN)c2ccccc2)sc1-c1ccnc2[nH]ccc12 CHEMBL469781 IC50 8.0 nM
NCCC(NC(=O)c1cc(Br)c(-c2ccnc3[nH]ccc23)s1)c1ccccc1 CHEMBL469802 IC50 8.0 nM
C[C@@H]1CN(c2ncc3cc(-c4ccccc4)c(-c4ccc(CN5CCC(c6nnc(-c7ccccn7)[nH]6)CC5)cc4)nc3n2)CCN1 CHEMBL503980 IC50 8.0 nM
Cc1n[nH]c2ccc(-c3cc(OC[C@@H](N)Cc4c[nH]c5ncccc45)cnc3-c3ccoc3)cc12 CHEMBL594310 IC50 8.0 nM
N[C@H](CNc1ncc(-c2ccc3[nH]c(=O)oc3c2)s1)Cc1ccc(C(F)(F)F)cc1 CHEMBL1081852 IC50 8.0 nM
CCn1c(-c2nonc2N)nc2c(C#CC(C)(C)O)nc(OC[C@@H](C)N)cc21 CHEMBL1098944 IC50 8.0 nM
N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCN(c2ccnc3[nH]ccc23)CC1 CHEMBL1258331 IC50 8.0 nM
Cc1cc(F)ccc1S(=O)(=O)NC[C@@H](O)CN1CCC[C@@]2(CCN(c3ncnc(N)c3C3CC3)C2)C1 CHEMBL1760773 IC50 8.0 nM
CC(=O)Nc1nc2ccc(-c3cnc(Cl)c(NS(=O)(=O)c4ccccc4C(F)(F)F)c3)cc2s1 CHEMBL1773606 IC50 8.0 nM
Cc1c(NCCN2CCCC2)cc(COCC(F)(F)F)cc1N1CCN(c2ncnc3[nH]nc(Br)c23)CC1 CHEMBL2016888 IC50 8.0 nM
Nc1ncccc1-c1nc2cc(-c3cccnc3)cnc2n1-c1ccc(CNC(=O)c2ccccc2)cc1 CHEMBL2177831 IC50 8.0 nM
COCCNC[C@@H](C(=O)N1CCN(c2ncnc3c2[C@H](C)C[C@H]3O)CC1)c1ccc(Cl)cc1 CHEMBL2177377 IC50 8.0 nM
CC(NC(=O)C1(N)CCN(c2ncnc3[nH]ccc23)CC1)c1ccc(Cl)cc1 CHEMBL2325997 IC50 8.0 nM
CCC1(O)CC(N)(c2ccc(-c3nc4n(c3-c3ccccc3)COc3nccnc3-4)cc2)C1 CHEMBL3701757 IC50 8.0 nM
Fc1ccc(-c2cn3ccnc3nc2-c2ccc(CN3CCC(c4n[nH]c(-c5ccccn5)n4)CC3)cc2)cc1 CHEMBL3672061 IC50 8.0 nM
COc1nn2cc(-c3c(F)cccc3F)c(-c3ccc(CN4CC(c5n[nH]c(-c6cccc(C)n6)n5)C4)cc3)nc2c1CO CHEMBL3672074 IC50 8.0 nM
CC1CN(c2cc(=O)[nH]c(CC(=O)N3CCc4c(F)cccc43)n2)CCO1 CHEMBL3928308 IC50 8.0 nM
CC1Cc2c(OC(F)F)cccc2N1C(=O)Cc1nc(N2CCOCC2)cc(=O)[nH]1 CHEMBL3964324 IC50 8.0 nM
C[C@@H]1Cc2ccccc2N1C(=O)Cc1nc(N2CCOCC2)cc(=S)[nH]1 CHEMBL3898401 IC50 8.0 nM
CCOc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C(F)(F)F)c3)cn2CCN(C)C)CC1 CHEMBL3976247 IC50 8.0 nM
Cn1ncc(Cl)c1-c1cc(C(=O)N[C@@H]2CNCC[C@H]2c2cccc(C(F)(F)F)c2)oc1Cl CHEMBL4585120 IC50 8.0 nM
NC1(c2ccc(-c3nc4ccn5c(=O)[nH]nc5c4cc3-c3ccccc3)cc2)CCC1 CHEMBL4635254 IC50 8.0 nM
Nc1ncnc(N2CCC(c3nc(-c4cccc(F)c4)cn3CCN3CCCC3)CC2)c1Cl CHEMBL3978595 IC50 8.1 nM
Nc1ncnc(N2CCC(c3nc(-c4cccc(C(F)(F)F)c4)cn3CCN3CCCC3)CC2)c1C1CCC1 CHEMBL3981168 IC50 8.1 nM
Cn1cccc1CC(C)(C)C1C(=O)Nc2ccc(-c3cncc(OC[C@@H](N)Cc4c[nH]c5ccccc45)c3)cc21 CHEMBL379963 IC50 8.2 nM
Cn1cccc1C1C(=O)Nc2ccc(-c3cncc(OC[C@@H](N)Cc4c[nH]c5ccccc45)c3)cc21 CHEMBL583705 IC50 8.2 nM
CC(=N)n1c(=N)ccc2nc(-c3ccc(C4(N)CCC4)cc3)c(-c3ccccc3)cc21 CHEMBL3679630 IC50 8.2 nM
NC1(c2ccc(-c3nc4n(c3-c3ccccc3)COc3cccc(Cl)c3-4)cc2)CC(O)(C2CC2)C1 CHEMBL3701737 IC50 8.2 nM
CCOc1c(N)ncnc1N1CCC(c2nc(-c3ccnc(C(F)(F)F)c3)cn2CCN2CCC2)CC1 CHEMBL3959379 IC50 8.2 nM
CCc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(F)c3)cn2CCN2CCCC2)CC1 CHEMBL3954781 IC50 8.2 nM
CCOC(=O)c1c(C)nc(NNC(=O)c2cccc3c(=O)c4ccccc4[nH]c23)nc1-c1ccccc1F CHEMBL4160193 IC50 8.2 nM
COc1ncc(-c2cc3c(C)nc(N)nc3n([C@H]3CC[C@@H](OCC(N)=O)CC3)c2=O)cc1F CHEMBL2375963 IC50 8.22 nM
Cc1n[nH]c2ccc(-c3cncc(NC[C@@H](N)Cc4ccccc4)c3)cc12 CHEMBL207338 Ki 8.3 nM
Cc1n[nH]c2ccc(-c3cncc(OC[C@@H](N)Cc4cccc5ccccc45)c3)cc12 CHEMBL210349 Ki 8.3 nM
N[C@H](COc1cncc(-c2cc3c(-c4ccccc4)n[nH]c3cn2)c1)Cc1ccccc1 CHEMBL226383 IC50 8.3 nM
Cc1n[nH]c2ccc(-c3cncc(OC[C@@H](N)Cc4cccc(F)c4)c3)cc12 CHEMBL229314 IC50 8.4 nM
Cc1n[nH]c2cnc(-c3cncc(OC[C@@H](N)Cc4cccc(F)c4)c3)cc12 CHEMBL573592 IC50 8.4 nM
N#Cc1c(N)ncnc1N1CCC(c2nc(-c3cccc(Cl)c3)cn2CCN2CCCC2)CC1 CHEMBL3918965 IC50 8.4 nM
Cc1cc(-c2cn(CCNCC3CC3)c(C3CCN(c4ncnc(N)c4C(N)=O)CC3)n2)ccc1F CHEMBL3974713 IC50 8.4 nM
NC(=O)c1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C(F)(F)F)c3)cn2CCNC2CCCC2)CC1 CHEMBL3951639 IC50 8.4 nM
Cc1n[nH]c2ccc(-c3cncc(OC[C@@H](N)Cc4cccc(F)c4F)c3)cc12 CHEMBL438483 IC50 8.5 nM
CSc1ncc2cc(-c3ccccc3)c(-c3ccc(CN4CCC(c5nnc(N)s5)CC4)cc3)nc2n1 CHEMBL403356 IC50 8.5 nM
NC(=O)Nc1nnc2c3cc(-c4ccccc4)c(-c4ccc(CN5CCC(c6n[nH]c(-c7ccccn7)n6)CC5)cc4)nc3ccn12 CHEMBL509747 IC50 8.5 nM
N[C@H](CNc1ncc(-c2ccc3[nH]ncc3c2)s1)Cc1ccc(C(F)(F)F)cc1 CHEMBL1081829 IC50 8.5 nM
CC1(O)CC(N)(c2ccc(-c3nc4n(c3-c3ccccc3)COc3cc(F)ccc3-4)cc2)C1 CHEMBL3701725 IC50 8.5 nM
CC1(O)CC(N)(c2ccc(-c3nc4n(c3-c3ccccc3)COc3cc(CO)ccc3-4)cc2)C1 CHEMBL3701759 IC50 8.6 nM
CC(=O)Nc1nc2ccc(-c3cnc(Cl)c(NS(=O)(=O)c4ccc(Cl)cc4)c3)cc2s1 CHEMBL1773732 IC50 8.7 nM
Nc1ncccc1-c1nc2ccc(Nc3ccc(N4CCOCC4)cc3)nc2n1-c1ccc(C2(N)CCC2)cc1 CHEMBL3640749 IC50 8.72 nM
Cn1ncc(Cl)c1-c1cc(C(=O)N[C@@H]2CN[C@H](CCN3CCOCC3)C[C@H]2c2ccc(Cl)c(Cl)c2)oc1Cl CHEMBL4450403 IC50 8.78 nM
CC(C)(C)c1ccc(CC2(N)CCN(c3ncnc4[nH]c(=O)[nH]c34)CC2)cc1 CHEMBL598841 GI50 8.8 nM
Cc1n[nH]c2ccc(-c3nnc(NC[C@@H](N)Cc4ccc(Cl)cc4)s3)cc12 CHEMBL1080740 IC50 8.9 nM
Cc1cc(-c2cn(CCN3CCCC3)c(C3CCN(c4ncnc(N)c4OC(C)C)CC3)n2)ccc1F CHEMBL3939239 IC50 8.9 nM
CCc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C)c3)cn2CCN(CC)C(C)C)CC1 CHEMBL3968774 IC50 8.9 nM
CCn1c(-c2nonc2N)nc2c(C#CC(C)(C)O)ncc(OCCCCN)c21 CHEMBL493269 IC50 9.0 nM
OCCN1CCN(c2ncc3cc(-c4ccccc4)c(-c4ccc(CN5CCC(c6nnc(-c7ccccn7)[nH]6)CC5)cc4)nc3n2)CC1 CHEMBL453995 IC50 9.0 nM
CN1CCN(c2ncc3cc(-c4ccccc4)c(-c4ccc(CN5CCC(c6nnc(-c7ccccn7)[nH]6)CC5)cc4)nc3n2)CC1 CHEMBL504251 IC50 9.0 nM
Cc1cccc(C)c1S(=O)(=O)N1CCC[C@H]1[C@@H](O)CN1CCC[C@@]2(CCN(c3ncnc(N)c3C3CC3)C2)C1 CHEMBL1760765 IC50 9.0 nM
Cc1ccccc1S(=O)(=O)NC[C@@H](O)CN1CCC[C@@]2(CCN(c3ncnc(N)c3C3CC3)C2)C1 CHEMBL1760769 IC50 9.0 nM
Nc1ncnc(N2CC[C@@]3(CCCN(C[C@H](O)CNS(=O)(=O)c4ccccc4Cl)C3)C2)c1C1CC1 CHEMBL1760771 IC50 9.0 nM
CCOCCN(C[C@@H](O)CN1CCCC2(CCc3c(ccc4[nH]ncc34)O2)C1)S(=O)(=O)c1c(C)cccc1C CHEMBL1761090 IC50 9.0 nM
CC(=O)Nc1nc2ccc(-c3cnc(Cl)c(NS(=O)(=O)c4ccccc4F)c3)cc2s1 CHEMBL1773735 IC50 9.0 nM
Cc1c(NCCN2CCCC2)cc(OCC(C)C)cc1N1CCN(c2ncnc3[nH]nc(Br)c23)CC1 CHEMBL2016886 IC50 9.0 nM
C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(C(=O)[C@@H](c4ccc(Cl)cc4)[C@@H]4CCCCN4)CC3)c21 CHEMBL2177369 IC50 9.0 nM
C[C@@H]1C[C@@H](O)c2ncnc(N3CCN(C(=O)[C@H](CNC4CCCCC4)c4ccc(Cl)cc4)CC3)c21 CHEMBL2177364 IC50 9.0 nM
CC(NC(=O)C1(N)CCN(c2ncnc3[nH]ccc23)CC1)c1ccc(F)cc1 CHEMBL2325987 IC50 9.0 nM
Cc1nc2nc(-c3ccc(CN4CC(c5n[nH]c(-c6ccccn6)n5)C4)cc3)c(-c3ccccc3)c(NC(C)C)n2n1 CHEMBL3672049 IC50 9.0 nM
Cc1cccc(-c2nc(C3CCN(Cc4ccc(-c5nc6nccn6cc5-c5ccc(F)cc5)cc4)CC3)n[nH]2)n1 CHEMBL3672060 IC50 9.0 nM
NC1(c2ccc(-c3nn4c(-c5ccc(F)c(CO)c5)cnc4cc3-c3ccccc3)cc2)CCC1 CHEMBL3672490 IC50 9.0 nM
NC1(c2ccc(-c3nn4c(-c5cn[nH]c5)cnc4cc3-c3ccccc3)cc2)CCC1 CHEMBL3672493 IC50 9.0 nM
CC1Cc2ccc(F)cc2N1C(=O)Cc1nc(N2CCOCC2)cc(=O)[nH]1 CHEMBL3896158 IC50 9.0 nM
O=C(Cc1nc(N2CCOCC2)cc(=O)[nH]1)N1CCc2c1cccc2C(F)(F)F CHEMBL3112853 IC50 9.0 nM
Nc1ncnc(N2CCC(c3nc(-c4ccc(F)c(C(F)(F)F)c4)cn3CCN3CCCCC3)CC2)c1Br CHEMBL3956468 IC50 9.0 nM
Nc1ncnc(N2CCC(c3nc(-c4ccc(F)c(C(F)(F)F)c4)cn3CCN3CCCCC3)CC2)c1Cl CHEMBL3938237 IC50 9.0 nM
Cc1cnn(C)c1-c1ccc(C(=O)N[C@@H]2CNCC[C@H]2c2cccc(F)c2)s1 CHEMBL4579551 IC50 9.0 nM
CN(C)CCn1cc(-c2ccc(F)c(C(F)(F)F)c2)nc1C1CCN(c2ncnc(N)c2C#N)CC1 CHEMBL3916864 IC50 9.1 nM
CC(C)Oc1c(N)ncnc1N1CCC(c2nc(-c3ccnc(C(F)(F)F)c3)cn2CCN2CCC2)CC1 CHEMBL3927446 IC50 9.1 nM
Nc1ncnc(N2CCC(c3nc(-c4ccc(C(F)(F)F)c(F)c4)cn3CCN3CCCC3)CC2)c1C1CCC1 CHEMBL3915954 IC50 9.1 nM
CCc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(Cl)c3)cn2CCN2CCC2)CC1 CHEMBL3985540 IC50 9.2 nM
Cn1nccc1-c1cc(F)c(C(=O)N[C@@H]2CNCC[C@H]2c2ccc(F)c(F)c2)cc1F CHEMBL4855363 IC50 9.2 nM
CN(C)CCn1cc(-c2ccc(F)c(C(F)(F)F)c2)nc1C1CCN(c2ncnc(N)c2Br)CC1 CHEMBL3961106 IC50 9.3 nM
CCc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(C(F)(F)F)c3)cn2CCN2CCCCC2)CC1 CHEMBL3899177 IC50 9.3 nM
N#Cc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(F)c3)cn2CCN2CCC2)CC1 CHEMBL3950203 IC50 9.3 nM
Cn1ncc(Cl)c1-c1cc(C(=O)N[C@@H]2CNCC[C@H]2c2ccc(C(F)(F)F)cc2)oc1Cl CHEMBL4591854 IC50 9.3 nM
Nc1ncnc(N2CCC(c3nc(-c4ccc(F)c(F)c4)cn3CCN3CCCC3)CC2)c1C1CCC1 CHEMBL3961562 IC50 9.4 nM
CCc1c(N)ncnc1N1CCC(c2nc(-c3cccc(C(F)(F)F)c3)cn2CCN2CCCC2)CC1 CHEMBL3982706 IC50 9.6 nM
N[C@H](CNc1cncc(/C=C/c2ccncc2)c1)Cc1c[nH]c2ccccc12 CHEMBL203624 IC50 9.7 nM
CSc1ncc2cc(-c3ccccc3)c(-c3ccc(CN4CCC(C(=O)Nc5ccncc5)CC4)cc3)nc2n1 CHEMBL252856 IC50 9.7 nM
N#Cc1c(N)ncnc1N1CCC(c2nc(-c3ccnc(C(F)(F)F)c3)cn2CCN2CCC2)CC1 CHEMBL3947888 IC50 9.7 nM
C=Cc1c(N)ncnc1N1CCC(c2nc(-c3ccc(F)c(F)c3)cn2CCN2CCCC2)CC1 CHEMBL3913177 IC50 9.7 nM
CC(C)(C)NCCn1cc(-c2ccc(F)c(C(F)(F)F)c2)nc1C1CCN(c2ncnc(N)c2C(N)=O)CC1 CHEMBL3904852 IC50 9.7 nM
N[C@H](COc1cncc(-c2ccc3[nH]nc(-c4nccs4)c3c2)c1)Cc1c[nH]c2ccccc12 CHEMBL574995 IC50 9.8 nM
CC1(O)CC(N)(c2ccc(-c3nc4n(c3-c3ccsc3)COc3cccc(F)c3-4)cc2)C1 CHEMBL3701722 IC50 9.8 nM
CN1CCN(Cc2nnc3c4cc(-c5ccccc5)c(-c5ccc(CN6CCC(c7n[nH]c(-c8ccccn8)n7)CC6)cc5)nc4ccn23)CC1 CHEMBL446779 IC50 9.9 nM