COc1cc(N2CCC(N(C)C)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2P(C)(C)=O)n1 CHEMBL3397300 IC50 0.07 nM
Cc1nn(C)c2c1-c1cnc(N)c(n1)O[C@H](C)c1cc(F)ccc1C(=O)N(C)C2 CHEMBL3286823 Ki 0.1 nM
COc1nn(C)c2c1-c1cnc(N)c(c1)O[C@H](C)c1cc(F)ccc1C(=O)N(C)C2 CHEMBL3286825 Ki 0.1 nM
COc1nn(C)c2c1-c1cnc(N)c(n1)O[C@H](C)c1cc(F)ccc1C(=O)N(C)C2 CHEMBL3286826 IC50 0.11 nM
C[C@H]1Oc2nc(cnc2N)-c2cc(S(C)(=O)=O)ccc2CN(C)C(=O)c2ccc(F)cc21 CHEMBL3286828 Ki 0.12 nM
CCP(=O)(CC)c1ccccc1Nc1nc(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)cc2OC)ncc1Cl CHEMBL3824308 IC50 0.12 nM
COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 CHEMBL509032 IC50 0.15 nM
CC1(C)c2cc(N3CCC(N)CC3)c(Br)cc2C(=O)c2c1[nH]c1cc(C#N)ccc21 CHEMBL3892880 IC50 0.168 nM
CC(C)c1nc(C(N)=O)c(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)c(C(F)(F)F)c2)nc1N[C@H]1CC[C@H](O)CC1 CHEMBL3687205 IC50 0.17 nM
COc1cc(N2CCN(CCO)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2P(C)(C)=O)n1 CHEMBL3823235 IC50 0.18 nM
COc1cc(N2CCN(C)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2P(C)(C)=O)n1 CHEMBL3822611 IC50 0.18 nM
Cc1cc(Nc2ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n2)c(OC(C)C)cc1C1CCNCC1 CHEMBL2403108 IC50 0.2 nM
Cc1nc([C@](C)(O)CO)sc1-c1cnc(N)c(O[C@H](C)c2cc(F)ccc2-n2nccn2)c1 CHEMBL3128069 IC50 0.2 nM
C[C@H]1Oc2cc(cnc2N)-c2c(nn(C)c2C#N)CN(C)C(=O)c2ccc(F)cc21 CHEMBL3286830 IC50 0.2 nM
CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)c(C)c2)nc1N[C@H]1CC[C@@](C)(O)CC1 CHEMBL3687207 IC50 0.21 nM
N#Cc1[nH]nc2c1-c1cnc(N)c(c1)OCc1cc(F)ccc1OCCC2 CHEMBL3286815 Ki 0.22 nM
COc1cc(OCCCN2CCCC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2P(C)(C)=O)n1 CHEMBL3823549 IC50 0.22 nM
CCc1nc(C(N)=O)c(Nc2ccc(N3CCN(C)CC3)c(C)c2)nc1N[C@H]1CC[C@@](C)(O)CC1 CHEMBL3687206 IC50 0.22 nM
CCc1nc(C(N)=O)c(Nc2ccc(OC)c(N3CCN(C)CC3)c2)nc1N[C@H]1CC[C@H](O)CC1 CHEMBL3889838 IC50 0.23 nM
CC(C)NC(=O)[C@H]1CC[C@@H](n2/c(=N/C(=O)c3cc(F)cc(F)c3)[nH]c3ccc(CN4CCC(C(C)(C)O)CC4)cc32)CC1 CHEMBL2172315 Kd 0.24 nM
COc1cc(N2CCOCC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2P(C)(C)=O)n1 CHEMBL3823416 IC50 0.24 nM
CCc1nc(C(N)=O)c(Nc2ccc(N3CCN(C)CC3)c(C)c2)nc1N[C@H]1CC[C@H](O)CC1 CHEMBL3687201 IC50 0.24 nM
COc1cc2c(cc1Nc1ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n1)CNCC2 CHEMBL4743579 IC50 0.24 nM
CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)c(C)c2)nc1N[C@H]1CC[C@H](O)CC1 CHEMBL3687202 IC50 0.26 nM
CCc1nc(C(N)=O)c(Nc2ccc(C3CCN(C)CC3)cc2)nc1N[C@H]1CC[C@H](O)CC1 CHEMBL3687204 IC50 0.26 nM
CCOc1cc(Nc2nc(N[C@H]3CC[C@H](O)CC3)c(CC)nc2C(N)=O)ccc1N1CCC(N2CCN(C)CC2)CC1 CHEMBL3687211 IC50 0.26 nM
Cc1cc(NC2CCN(C)CC2)ccc1-c1cc2c(N3CCC[C@H](C(=O)NCc4ccc(OC(F)(F)F)cc4)C3)ncnc2[nH]1 CHEMBL4522012 IC50 0.27 nM
COc1cc(N2CCN(C3CCN(C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2P(C)(C)=O)n1 CHEMBL3824327 IC50 0.28 nM
Cc1nn(C)c2c1-c1cnc(N)c(c1)O[C@H](C)c1cc(F)ccc1C(=O)N(C)C2 CHEMBL3286820 Ki 0.29 nM
Cc1[nH][n+](C)c2c1-c1cnc(N)c(c1)O[C@H](C)c1cc(F)ccc1C(=O)N(C)C2 CHEMBL4286522 Ki 0.29 nM
Cc1nc(C2(O)CN(C)C2)sc1-c1cnc(N)c(O[C@H](C)c2cc(F)ccc2-n2nccn2)c1 CHEMBL3128066 Ki 0.3 nM
C[C@@H]1CN(c2cc3c(cc2Br)C(=O)c2c([nH]c4cc(C#N)ccc24)C3(C)C)C[C@H](C)N1C1CCC1 CHEMBL3917178 IC50 0.3 nM
CCc1cc2c(cc1N1CCC(N3CCC3)CC1)C(C)(C)c1[nH]c3cc(C#N)ccc3c1C2=O CHEMBL3953815 IC50 0.3 nM
CCc1cc2c(cc1N1CCC(N3CCC(O)CC3)CC1)C(C)(C)c1[nH]c3cc(C#N)ccc3c1C2=O CHEMBL3929615 IC50 0.3 nM
COc1cc(N2CCC(N3CCOCC3)CC2)ccc1-c1nc2c(N[C@H]3[C@@H](C(N)=O)[C@@H]4C=C[C@H]3C4)c(Cl)cnc2[nH]1 CHEMBL3218856 IC50 0.31 nM
COc1cc(P(C)(C)=O)ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 CHEMBL3824304 IC50 0.31 nM
C#Cc1cc2c(cc1N1CCN(C3CCC3)CC1)C(C)(C)c1[nH]c3cc(C#N)ccc3c1C2=O CHEMBL3946496 IC50 0.32 nM
CC(C)(C)N1CCN(c2cc3c(cc2Br)C(=O)c2c([nH]c4cc(C#N)ccc24)C32CCOCC2)CC1 CHEMBL3915577 IC50 0.32 nM
COc1cc(N2CC[C@@H](N(C)C)C2)ccc1Nc1ncc(Cl)c(Nc2ccccc2P(C)(C)=O)n1 CHEMBL3823107 IC50 0.33 nM
COc1cc(OC2CCN(C)C2)ccc1Nc1ncc(Cl)c(Nc2ccccc2P(C)(C)=O)n1 CHEMBL3823603 IC50 0.33 nM
COc1cc(P(C)(C)=O)ccc1Nc1ncc(Cl)c(Nc2ccccc2S(C)(=O)=O)n1 CHEMBL3823256 IC50 0.33 nM
CCc1nc(C(N)=O)c(Nc2ccc(N3CCN(C)CC3)c(OC)c2)nc1N[C@H]1CC[C@H](O)CC1 CHEMBL3687198 IC50 0.33 nM
COc1cc2c(cc1Nc1ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n1)CCC1=NNCCN12 CHEMBL4101954 IC50 0.33 nM
CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(N(C)C)C3)c(C(F)(F)F)c2)nc1N[C@H]1CC[C@H](O)CC1 CHEMBL3687209 IC50 0.34 nM
CC(C)NC(=O)[C@H]1CC[C@@H](n2/c(=N/C(=O)c3ccc(F)cc3)[nH]c3ccc(CN4CCC(C(C)(C)O)CC4)cc32)CC1 CHEMBL2172308 Kd 0.36 nM
N#Cc1[nH]nc2c1-c1cnc(N)c(c1)OCc1cc(F)ccc1OCC2 CHEMBL3286814 Ki 0.36 nM
COc1cc(N2CCC(O)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2P(C)(C)=O)n1 CHEMBL3823017 IC50 0.36 nM
COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2P(C)(C)=O)n1 CHEMBL3545311 IC50 0.37 nM
CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)c(OC)c2)nc1N[C@H]1CC[C@H](O)CC1 CHEMBL3687193 IC50 0.37 nM
Cn1ncc2c1-c1cnc(N)c(c1)OCc1cc(F)ccc1OCCC2 CHEMBL3286816 Ki 0.38 nM
COc1cc(C2CCN(C)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2P(C)(C)=O)n1 CHEMBL3823190 IC50 0.38 nM
COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(F)c(Nc2ccccc2P(C)(C)=O)n1 CHEMBL3823296 IC50 0.39 nM
CC1(C)c2cc(N3CCC(N4CCOCC4)CC3)c(Cl)cc2C(=O)c2c1[nH]c1cc(C#N)ccc21 CHEMBL3944715 IC50 0.391 nM
COc1cc2c(cc1Nc1nc(Nc3ccsc3C(N)=O)c3cc[nH]c3n1)N(C(=O)CN(C)C)CC2 CHEMBL514873 IC50 0.4 nM
Cc1nc(C(C)(C)O)sc1-c1cnc(N)c(O[C@H](C)c2cc(F)ccc2-n2nccn2)c1 CHEMBL3128064 Ki 0.4 nM
C[C@H]1Oc2cc(cnc2N)-c2cc(S(C)(=O)=O)ccc2CN(C)C(=O)c2ccc(F)cc21 CHEMBL3286827 Ki 0.4 nM
CC(C)OCC#Cc1cc2c(cc1N1CCN(C3COC3)CC1)C(C)(C)c1[nH]c3cc(C#N)ccc3c1C2=O CHEMBL3936548 IC50 0.4 nM
CCc1cc2c(cc1N1CCN(C(=O)CN(C)C)CC1)C(C)(C)c1[nH]c3cc(C#N)ccc3c1C2=O CHEMBL3986700 IC50 0.4 nM
COc1cc(CCN(C)C)c(C)cc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 CHEMBL4099660 IC50 0.4 nM
CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2ccc(NC(=O)CCCCCCC(=O)NO)cc2)ncc1Cl CHEMBL4855319 IC50 0.4 nM
COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(C)c(Nc2ccccc2P(C)(C)=O)n1 CHEMBL3823577 IC50 0.42 nM
CC1(C)c2cc(O)c(-c3nn[nH]n3)cc2C(=O)c2c1[nH]c1cc(Cl)ccc21 CHEMBL3938280 IC50 0.456 nM
C[C@@H](Oc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl CHEMBL601719 EC50 0.47 nM
COc1cc(N2CCC(N3CCCN(C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2P(C)(C)=O)n1 CHEMBL3824290 IC50 0.49 nM
COc1cc(N2CCC(N3CCOCC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2P(C)(C)=O)n1 CHEMBL3822557 IC50 0.49 nM
CCc1nc(C(N)=O)c(Nc2ccc(N3CCN(C(C)C)CC3)c(C)c2)nc1N[C@H]1CC[C@H](O)CC1 CHEMBL3687210 IC50 0.49 nM
COc1cc2c(=O)c3c4ccc(C#N)cc4[nH]c3n(C(C)C)c2c(F)c1C1CCN(C)CC1 CHEMBL4790570 IC50 0.49 nM
CC1(C)c2cc(N3CCC(N4CCCCC4)CC3)ncc2C(=O)c2c1[nH]c1cc(C#N)ccc21 CHEMBL3969707 IC50 0.4938 nM
COc1cc(N2CCN(C(C)C)CC2)ccc1Nc1nc(Nc2cccc(F)c2C(N)=O)c2cc[nH]c2n1 CHEMBL507625 IC50 0.5 nM
COc1cc2c(cc1Nc1ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n1)CC/C(=N\N1CCN(C)CC1)C2(C)C CHEMBL3785774 IC50 0.5 nM
CC(C)Oc1cc(C2CCN(C)CC2)ccc1Nc1ncc2sc(C(N)=O)c(-c3ccccc3OC(F)(F)F)c2n1 CHEMBL3669137 IC50 0.5 nM
CCN1CCC(c2cc(Nc3ncc4sc(C(N)=O)c(-c5ccccc5OC(F)(F)F)c4n3)n(C(C)C)n2)CC1 CHEMBL3669142 IC50 0.5 nM
CNC(=O)c1c(F)cccc1Nc1nc(Nc2cc3c(cc2OC)CCN3C(=O)CN(C)C)nc2[nH]ccc12 CHEMBL464552 IC50 0.5 nM
C=CC(=O)NCCOCCNC(=O)CCN1CCC(c2cc(OC(C)C)c(Nc3ncc(Cl)c(Nc4ccccc4S(=O)(=O)C(C)C)n3)cc2C)CC1 CHEMBL4753933 IC50 0.5 nM
COc1cc(N2CCN(C)CC2)c2cc1Nc1ncc(Cl)c(n1)Nc1cc(ccc1N(C)S(C)(=O)=O)CC2 CHEMBL1946804 IC50 0.51 nM
COc1cc(N2CCC(N3CCCC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2P(C)(C)=O)n1 CHEMBL3823031 IC50 0.53 nM
CCN(CC)CCOc1cc2c(cc1C(C)=O)C(=O)c1c([nH]c3cc(C#N)ccc13)C2(C)C CHEMBL3932266 IC50 0.53 nM
COc1cc(OC2CCN(C)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2P(C)(C)=O)n1 CHEMBL3823916 IC50 0.54 nM
CC(C)Oc1cc2c(cc1Nc1ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n1)CCNC2 CHEMBL4758611 IC50 0.54 nM
C[C@H]1Oc2nc(cnc2N)-c2c(nc3ccc(C#N)cn23)CN(C)C(=O)c2ccc(F)cc21 CHEMBL3286832 Ki 0.56 nM
C[C@H]1Oc2cc(cnc2N)-c2c(nn(C)c2C#N)CCOc2ccc(F)cc21 CHEMBL3286818 Ki 0.57 nM
CC1(C)c2cc(N3CCN(C4CCC4)CC3)c(C#CC3CCC3)cc2C(=O)c2c1[nH]c1cc(C#N)ccc21 CHEMBL3915056 IC50 0.58 nM
COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2S(C)(=O)=O)n1 CHEMBL3822475 IC50 0.59 nM
COc1cc(N2CCN(C(C)=O)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2P(C)(C)=O)n1 CHEMBL3824007 IC50 0.59 nM
CC1(C)c2cc(N3CCOCC3)c(OC3CCOC3)cc2C(=O)c2c1[nH]c1cc(C#N)ccc21 CHEMBL3936102 IC50 0.59 nM
C=CC(=O)Nc1cc(Nc2ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n2)c(OC)cc1N1CCCN(C)CC1 CHEMBL4159909 IC50 0.59 nM
CCc1cc2c(cc1N1CCC(N3CCOCC3)CC1)C(C)(C)c1[nH]c3cc(C#N)ccc3c1C2=O CHEMBL1738797 IC50 0.59 nM
Cc1nc(C2(O)CCOC2)sc1-c1cnc(N)c(O[C@H](C)c2cc(F)ccc2-n2nccn2)c1 CHEMBL3128067 Ki 0.6 nM
Cc1cc(O)cc(-c2nn(CC#N)cc2-c2cc(NC[C@H](C)O)nc(-c3cccnc3)n2)c1 CHEMBL560733 IC50 0.6 nM
CCc1cc2c(cc1N1CCC(NCCCO)CC1)C(C)(C)c1[nH]c3cc(C#N)ccc3c1C2=O CHEMBL3939751 IC50 0.6 nM
CN1CCN(C(=O)c2ccc(-c3cc4c(N5CCC[C@H](C(=O)NCc6ccc(OC(F)(F)F)cc6)C5)ncnc4[nH]3)cc2)CC1 CHEMBL4461100 IC50 0.6 nM
Cc1cc(NC2CCN(C)CC2)ccc1-c1cc2c(N3CCC[C@H](C(=O)NCc4ccc(S(F)(F)F)cc4)C3)ncnc2[nH]1 CHEMBL4588120 IC50 0.6 nM
C[C@H]1Oc2cc(cnc2N)-c2c(nn(C)c2C#N)CCCOc2ccc(F)cc21 CHEMBL3286819 Ki 0.62 nM
COc1cc2c(=O)c3c4ccc(C#N)cc4[nH]c3n(C(C)C)c2c(F)c1C1CCN(CCO)CC1 CHEMBL4799217 IC50 0.62 nM
C[C@@H]1Oc2cc(cnc2N)-c2c(C#N)nn(C)c2CCCOc2ccc(F)cc21 CHEMBL5438242 Ki 0.62 nM
Cc1cc(NC2CCN(C)CC2)ccc1-c1cc2c(N3CCC[C@H](C(=O)NCc4cccc(OC(F)(F)F)c4)C3)ncnc2[nH]1 CHEMBL4537938 IC50 0.64 nM
COc1cc(CN2CCN(C)CC2)ccc1-c1nc2c(N[C@H]3[C@@H](C(N)=O)[C@@H]4C=C[C@H]3C4)c(Cl)cnc2[nH]1 CHEMBL3218859 IC50 0.65 nM
CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)c(C(F)(F)F)c2)nc1N[C@H]1CC[C@H](O)CC1 CHEMBL3687200 IC50 0.65 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL388978 IC50 0.67 nM
CC(C)Oc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2P(C)(C)=O)n1 CHEMBL3823224 IC50 0.68 nM
COc1cc(P(C)(C)=O)ccc1Nc1ncc(Cl)c(Nc2ccccc2C(N)=O)n1 CHEMBL3823268 IC50 0.68 nM
COc1cc(N2CCN(C)CC2)ccc1-c1nc2c(N[C@H]3[C@@H](C(N)=O)[C@@H]4C=C[C@H]3C4)c(Cl)cnc2[nH]1 CHEMBL3218855 IC50 0.69 nM
COc1ncccc1-c1cnc(N)c(O[C@H](C)c2cc(F)ccc2-n2nccn2)n1 CHEMBL3286811 Ki 0.7 nM
CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2cccc(NC(=O)CN3CCN(C(=O)/C=C/CN(C)C)CC3)c2)ncc1Cl CHEMBL3357458 IC50 0.7 nM
COc1cc2c(cc1Nc1ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n1)CCC(N)C2(C)C CHEMBL3786892 IC50 0.7 nM
CCc1cc2c(cc1N1CCC(N3CCN(C)CC3)CC1)C(C)(C)c1[nH]c3cc(C#N)ccc3c1C2=O CHEMBL3902757 IC50 0.7 nM
COc1ccc(NC(=O)C(C)NC(=O)c2cc(C(C)C)c(O)cc2O)cc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 CHEMBL4172925 IC50 0.7 nM
COc1ccc(NC(=O)CNC(=O)c2cc(C(C)C)ccc2O)cc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 CHEMBL4168049 IC50 0.7 nM
C[C@H]1Oc2cc(cnc2N)Cc2c(nn(C)c2C#N)CN(C)C(=O)c2ccc(F)cc21 CHEMBL4436406 Ki 0.7 nM
CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2ccc3c(NC(=O)CN4CCCC4)n[nH]c3c2)ncc1Cl CHEMBL5208148 IC50 0.71 nM
COc1cc(N2CCCN(C)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2P(C)(C)=O)n1 CHEMBL3824130 IC50 0.72 nM
COc1cc(N2CCN(CCN(C)C)C2=O)ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 CHEMBL4470529 IC50 0.73 nM
COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)N(C)C)n1 CHEMBL3822672 IC50 0.75 nM
CCOc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2P(C)(C)=O)n1 CHEMBL3824318 IC50 0.75 nM
COc1cc(N2CCC(N)CC2)ccc1Nc1ncc(Cl)c(-c2c[nH]c3ccccc23)n1 CHEMBL4203266 Ki 0.75 nM
COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1-c1nc2c(N[C@H]3[C@@H](C(N)=O)[C@@H]4C=C[C@H]3C4)c(Cl)cnc2[nH]1 CHEMBL3218857 IC50 0.76 nM
COc1cc(-c2cnn(C3CCNCC3)c2)ccc1Nc1ncc(Cl)c(Nc2ccccc2P(C)(C)=O)n1 CHEMBL3822645 IC50 0.76 nM
CCc1nc(C(N)=O)c(Nc2ccc(N3CCN(C)CC3)c(C(F)(F)F)c2)nc1N[C@H]1CC[C@H](O)CC1 CHEMBL3687197 IC50 0.77 nM
CC(C)N1CCN(c2ccc3c(c2)C(C)(C)c2[nH]c4c(F)c(C#N)ccc4c2C3=O)CC1 CHEMBL3960260 IC50 0.77 nM
COc1cc(P(C)(C)=O)ccc1Nc1ncc(Cl)c(Nc2ccccc2C(C)=O)n1 CHEMBL3824326 IC50 0.79 nM
CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2cccc(NC(=O)C3CN(C(=O)CCCN(C)C)C3)c2)ncc1Cl CHEMBL3357452 IC50 0.8 nM
CCc1cc2c(cc1N1CCN(C(=O)C3COCCN3)CC1)C(C)(C)c1[nH]c3cc(C#N)ccc3c1C2=O CHEMBL3734938 IC50 0.8 nM
COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2C(N)=O)n1 CHEMBL3824246 IC50 0.8 nM
CC(C)c1cc(C(=O)NCC(=O)Nc2cccc(Nc3ncc(Cl)c(Nc4ccccc4S(=O)(=O)C(C)C)n3)c2)c(O)cc1O CHEMBL4162295 IC50 0.8 nM
Cn1cc(-c2cc3c(cc2N2CCOCC2)C(C)(C)c2[nH]c4cc(C#N)ccc4c2C3=O)cn1 CHEMBL3929315 IC50 0.81 nM
CCc1cc2c(cc1N1CCC(NCC3CC3)CC1)C(C)(C)c1[nH]c3cc(C#N)ccc3c1C2=O CHEMBL3981662 IC50 0.813 nM
CC1(C)c2ccc(C3=CCNCC3)cc2C(=O)c2c1[nH]c1cc(C#N)ccc21 CHEMBL3896252 IC50 0.83 nM
CC(C)N1CCC(c2ccc3c(c2)C(C)(C)c2[nH]c4cc(C#N)ccc4c2C3=O)CC1 CHEMBL3945000 IC50 0.84 nM
CNC(=O)c1ccc(F)cc1[C@@H](C)Oc1nc(-c2cccnc2OC)cnc1N CHEMBL3286812 Ki 0.85 nM
COc1cc(N2CCC(N3CCN(C)CC3)CC2)c(C)cc1Nc1ncc(Cl)c(Nc2ccccc2P(C)(C)=O)n1 CHEMBL3823836 IC50 0.86 nM
N#Cc1ccc2c3c([nH]c2c1)C1(CCOCC1)c1cc(N2CCC(N4CCCC4)CC2)c(C#N)cc1C3=O CHEMBL3921449 IC50 0.86 nM
Cc1cc(NC2CCN(C)CC2)ccc1-c1cc2c(N3CCC[C@H](C(=O)NCc4ccc(Cl)cc4)C3)ncnc2[nH]1 CHEMBL4466561 IC50 0.86 nM
COc1cc(N2CCN(CC(=O)N3CCN(C)CC3)C2=O)ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 CHEMBL4447747 IC50 0.87 nM
COc1cc(N2CCC(N3CCCCC3)C2)ccc1Nc1ncc(Cl)c(Nc2ccccc2P(C)(C)=O)n1 CHEMBL3823243 IC50 0.88 nM
COc1cc(N2CCC(CN3CCC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2P(C)(C)=O)n1 CHEMBL3823218 IC50 0.88 nM
CC1(C)c2cc(N3CCN(C4COC4)CC3)c(C#CC3CC3)cc2C(=O)c2c1[nH]c1cc(C#N)ccc21 CHEMBL3919367 IC50 0.881 nM
CCc1cc2c(cc1-c1cnn(C3CCNCC3)c1)C(C)(C)c1[nH]c3cc(C#N)ccc3c1C2=O CHEMBL3736273 IC50 0.9 nM
CC#Cc1cc2c(cc1N1CCC(N3CCOCC3)CC1)C1(CCOCC1)c1[nH]c3cc(C#N)ccc3c1C2=O CHEMBL3940191 IC50 0.9 nM
COc1cc(NC(=O)N2CCOCC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2NC(C)=O)n1 CHEMBL4562805 IC50 0.91 nM
CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)c(C)c2)nc1N[C@H]1CC[C@](C)(O)CC1 CHEMBL3687212 IC50 0.93 nM
CCc1nc(C(N)=O)c(Nc2ccc(N3CCN(C4CC4)CC3)c(C(F)(F)F)c2)nc1N[C@H]1CC[C@H](O)CC1 CHEMBL3687208 IC50 0.94 nM
COc1cc(N2CCN(CC(N)=O)C2=O)ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 CHEMBL4573193 IC50 0.95 nM
CC1(C)c2cc(N3CCN(C4COC4)CC3)c(Br)cc2C(=O)c2c1[nH]c1cc(C#N)ccc21 CHEMBL3981472 IC50 0.952 nM
COc1cc(P(C)(C)=O)ccc1Nc1ncc(Cl)c(Nc2ccccc2OC)n1 CHEMBL3822982 IC50 0.96 nM
C[C@H]1CN(C2CCC2)CCN1c1ccc2c(c1)C(C)(C)c1[nH]c3cc(C#N)ccc3c1C2=O CHEMBL3981666 IC50 0.981 nM
COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2C(C)O)n1 CHEMBL3822499 IC50 0.99 nM
CCc1nc(C(N)=O)c(Nc2cccc(S(C)(=O)=O)c2)nc1N[C@H]1CC[C@](C)(O)CC1 CHEMBL3687189 IC50 0.99 nM
CN1CCC(Oc2cc3c(cc2[N+](=O)[O-])C(=O)c2c([nH]c4cc(C#N)ccc24)C3(C)C)CC1 CHEMBL3986775 IC50 0.991 nM
CC1(C)c2cc(N3CCN(C4COC4)CC3)c(C#CCN3CCN(C4COC4)CC3)cc2C(=O)c2c1[nH]c1cc(C#N)ccc21 CHEMBL3920411 IC50 0.996 nM
CCCN1CCC=C(c2ccc(Nc3nc(Nc4ccccc4C(N)=O)c4cc[nH]c4n3)c(C)c2)C1 CHEMBL513897 IC50 1.0 nM
CN1CCN(c2ccc(C(=O)Nc3n[nH]c4ccc(Cc5cc(F)cc(F)c5)cc34)c(NC3CCOCC3)c2)CC1 CHEMBL1983268 pKi 1.0 nM
CNS(=O)(=O)c1ccccc1Nc1nc(Nc2ccc3c(c2)CCCC(=O)N3C)ncc1Cl CHEMBL2042694 IC50 1.0 nM
CC(C)NC(=O)[C@H]1CC[C@@H](n2/c(=N/C(=O)c3ccc(C#N)c(F)c3)[nH]c3ccc(CN4CCC(C(C)(C)O)CC4)cc32)CC1 CHEMBL2172304 IC50 1.0 nM
CC(C)NC(=O)[C@H]1CC[C@@H](n2/c(=N/C(=O)c3cccc(C#N)c3)[nH]c3ccc(CN4CCC(C(C)(C)O)CC4)cc32)CC1 CHEMBL2172321 IC50 1.0 nM
CC(C)NC(=O)[C@H]1CC[C@@H](n2/c(=N/C(=O)c3ccc(C#N)cc3)[nH]c3ccc(CN4CCC(C(C)(C)O)CC4)cc32)CC1 CHEMBL2172317 IC50 1.0 nM
CC(C)NC(=O)[C@H]1CC[C@@H](n2/c(=N/C(=O)c3ccncc3)[nH]c3ccc(CN4CCC(C(C)(C)O)CC4)cc32)CC1 CHEMBL2172316 IC50 1.0 nM
CC(C)NC(=O)[C@H]1CC[C@@H](n2/c(=N/C(=O)c3cccc(F)c3)[nH]c3ccc(CN4CCC(C(C)(C)O)CC4)cc32)CC1 CHEMBL2172314 IC50 1.0 nM
CC(C)NC(=O)[C@H]1CC[C@@H](n2/c(=N/C(=O)c3ccc(F)cc3)[nH]c3ccc(CNCC(C)(C)O)cc32)CC1 CHEMBL2172311 IC50 1.0 nM
CCOC(=O)[C@H]1CC[C@@H](n2/c(=N/C(=O)c3ccccc3)[nH]c3ccc(CN4CCCCC4)cc32)CC1 CHEMBL2172324 IC50 1.0 nM
CCc1cc2c(cc1C1=CCN(C(=O)C3CNC3)CC1)C(C)(C)c1[nH]c3cc(C#N)ccc3c1C2=O CHEMBL3736182 IC50 1.0 nM
Cc1cc(Nc2ncc(C)c(Nc3cn(C)nc3S(=O)(=O)C(C)C)n2)c(OC2CC2)cc1C1CCN(C)CC1 CHEMBL3785722 IC50 1.0 nM
Cc1cc(Nc2ncc(Cl)c(Nc3cn(C)nc3S(=O)(=O)C(C)C)n2)c(OC2CC2)cc1C1CCN(C)CC1 CHEMBL3604634 IC50 1.0 nM
CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)c(C)c2)nc1NC1CCNCC1 CHEMBL3687216 IC50 1.0 nM
COc1ncccc1-c1c(C(N)=O)sc2cnc(Nc3cc(F)c(C4CCN(C)CC4)cc3OC(C)C)nc12 CHEMBL3669144 IC50 1.0 nM
COc1cc(C(=O)NCCN(C)C)ccc1Nc1nc(Cc2c(Cl)cccc2Cl)n2ccnc2c1C(N)=O CHEMBL3949172 Ki 1.0 nM
COc1cc(C(=O)NCCN(C)C)ccc1Nc1nc(Cc2c(Cl)cccc2Cl)c2nc[nH]c2c1C(N)=O CHEMBL3919748 Ki 1.0 nM
COc1cc(C(=O)NCCN2CCCC2)ccc1Nc1nc(Cc2c(Cl)cccc2Cl)n2ccnc2c1C(N)=O CHEMBL3891699 Ki 1.0 nM
COc1cc(C(=O)NCCN2CCCCC2)ccc1Nc1nc(Cc2c(Cl)cccc2Cl)n2ccnc2c1C(N)=O CHEMBL3961811 Ki 1.0 nM
COc1cc(C(=O)N2CCNCC2)ccc1Nc1nc(Cc2c(Cl)cccc2Cl)n2ccnc2c1C(N)=O CHEMBL3978742 Ki 1.0 nM
COc1cc(CN2CCCC2)ccc1Nc1nc(Cc2c(Cl)cccc2Cl)c2nc[nH]c2c1C(N)=O CHEMBL3955742 Ki 1.0 nM
COc1cc2c(cc1Nc1nc(Cc3c(Cl)cccc3Cl)c3nc[nH]c3c1C(N)=O)CNCC2 CHEMBL3914113 Ki 1.0 nM
NC(=O)c1c(Nc2ccc(C3CCNCC3)cc2Cl)nc(Cc2ccccc2Cl)n2cnnc12 CHEMBL3936641 Ki 1.0 nM
CCOC(=O)c1cn2c(Cc3c(Cl)cccc3Cl)nc(Nc3ccc(N4CCNCC4)cc3OC)c(C(N)=O)c2n1 CHEMBL3965838 Ki 1.0 nM
CC(C)c1cc(C(=O)NCC(=O)Nc2ccc(F)c(Nc3ncc(Cl)c(Nc4ccccc4S(=O)(=O)C(C)C)n3)c2)c(O)cc1O CHEMBL4177038 IC50 1.0 nM
CCCc1cc2c(=O)c3c4ccc(C#N)cc4[nH]c3n(C(C)C)c2cc1N1CCN(C)CC1 CHEMBL4754012 IC50 1.0 nM
CCN1CCc2cc(OC)c(Nc3ncc(Cl)c(Nc4ccccc4S(=O)(=O)C(C)C)n3)cc2C1 CHEMBL4794087 IC50 1.0 nM
COc1cc2c(cc1Nc1ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n1)CCN(C(=O)CO)C2 CHEMBL4757036 IC50 1.0 nM
COc1cc2c(cc1Nc1ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n1)CCN(CCO)C2 CHEMBL4765021 IC50 1.0 nM
COc1cc2c(cc1Nc1ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n1)CCNC2 CHEMBL4782674 IC50 1.0 nM
CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2ccc(C(=O)NCCCCCCC(=O)NO)cc2)ncc1Cl CHEMBL4849606 IC50 1.0 nM
COc1cc(N2CCC3(CCN(C)CC3)CC2)c(Cl)cc1Nc1ncc(Cl)c(Nc2ccccc2P(C)(C)=O)n1 CHEMBL5171152 IC50 1.0 nM
C[C@H]1CNC(=O)c2cnn3ccc(nc23)N[C@H](C)c2cc(F)ccc2O1 CHEMBL4298138 IC50 1.01 nM
C[C@H]1CNC(=O)c2cnn3cc(cnc23)N[C@H](C)c2cc(F)cc(c2)O1 CHEMBL5173501 IC50 1.01 nM
COc1cc(N2CCC(N3CCN(C)CC3)CC2)c(F)cc1Nc1ncc(Cl)c(Nc2ccccc2P(C)(C)=O)n1 CHEMBL3823078 IC50 1.03 nM
COc1cc(P(C)(C)=O)ccc1Nc1ncc(Cl)c(Nc2ccccc2P(C)(C)=O)n1 CHEMBL3823165 IC50 1.06 nM
CCCc1cc2c(cc1N1CCN(CCCCO)CC1)C(C)(C)c1[nH]c3cc(C#N)ccc3c1C2=O CHEMBL3924077 IC50 1.093 nM
CCCc1cc2c(cc1N1CCC(N3CCOCC3)CC1)C(C)(C)c1[nH]c3cc(C#N)ccc3c1C2=O CHEMBL1940182 IC50 1.1 nM
Cc1cc2c(cc1N1CCC(N3CCOCC3)CC1)C(C)(C)c1[nH]c3cc(C#N)ccc3c1C2=O CHEMBL1940181 IC50 1.1 nM
Cc1nc([C@@](C)(O)CO)sc1-c1cnc(N)c(O[C@H](C)c2cc(F)ccc2-n2nccn2)c1 CHEMBL3124972 Ki 1.1 nM
CNC(=O)c1ccccc1Nc1nc(Nc2ccc3c(c2OC)CCC[C@H](N2CCN(CCO)CC2)C3)ncc1Cl CHEMBL3951811 Kd 1.1 nM
CC1(C)c2cc(N3CCN(C4CCS(=O)(=O)CC4)CC3)c(Br)cc2C(=O)c2c1[nH]c1cc(C#N)ccc21 CHEMBL3914907 IC50 1.134 nM
CC(C)(O)C#Cc1ccc2c(c1)C(=O)c1c([nH]c3cc(C#N)ccc13)C2(C)C CHEMBL3967479 IC50 1.171 nM
COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(OC)c(Nc2ccccc2P(C)(C)=O)n1 CHEMBL3823198 IC50 1.19 nM
CC(C)NC(=O)[C@H]1CC[C@@H](n2/c(=N/C(=O)c3ccc(F)cc3)[nH]c3ccc(CN4CCC(CN)CC4)cc32)CC1 CHEMBL2172335 IC50 1.2 nM
C[C@@H](Oc1cc(-c2cnn(C3CC4(CCNCC4)C3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl CHEMBL4113696 IC50 1.2 nM
CNC(C)(C)c1cc(OC)c(Nc2ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n2)cc1C CHEMBL4078406 IC50 1.2 nM
Cc1cc(-n2cc(S(C)(=O)=O)c3ccc(N[C@@H](C)c4ccc(F)cc4F)nc32)n[nH]1 CHEMBL4460367 IC50 1.2 nM
COc1cc2c(=O)c3c4ccc(C#N)cc4[nH]c3n(C(C)C)c2c(F)c1N1C[C@@H](C)N(C)[C@@H](C)C1 CHEMBL4764610 IC50 1.2 nM
CCC(C)Oc1cc2c(cc1Nc1ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n1)CCNC2 CHEMBL4745560 IC50 1.2 nM
CC(C)COc1cc2c(cc1Nc1ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n1)CCNC2 CHEMBL4780333 IC50 1.2 nM
CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)c(OC)c2)nc1NC1CCOCC1 CHEMBL3301622 IC50 1.2 nM
COc1cc2c(cc1Nc1nc(Nc3cccc(F)c3C(N)=O)c3cc[nH]c3n1)N(C(=O)CN(C)C)CC2 CHEMBL461876 pKi 1.259 nM
COc1ncccc1-c1cnc(N)c(O[C@H](C)c2cc(F)ccc2-n2nccn2)c1 CHEMBL3128061 Ki 1.3 nM
CNS(=O)(=O)c1ccccc1Nc1nc(Nc2ccc3c(c2)C(C)CN(C)CC3)ncc1Cl CHEMBL3263992 IC50 1.3 nM
CCc1cc2c(cc1N1CCN(C[C@@H]3CCC(=O)N3)CC1)C(C)(C)c1[nH]c3cc(C#N)ccc3c1C2=O CHEMBL3735794 IC50 1.3 nM
COc1ccc(NC(=O)CNC(=O)c2cc(C(C)C)c(O)cc2O)cc1Nc1ncnc(Nc2ccccc2S(=O)(=O)C(C)C)n1 CHEMBL4168701 IC50 1.3 nM
COc1cc2c(=O)c3c4ccc(C#N)cc4[nH]c3n(C(C)C)c2c(F)c1C1CCN(C2CCOCC2)CC1 CHEMBL4778565 IC50 1.3 nM
CC(C)n1c2cc(N3CCN(C)CC3)c(Br)cc2c(=O)c2c3ccc(C#N)cc3[nH]c21 CHEMBL4761644 IC50 1.3 nM
CC1Oc2cc(cnc2N)-c2c(nn(C)c2C#N)CN(C)C(=O)c2ccc(F)cc21 CHEMBL4303155 IC50 1.3 nM
CCN(CC)CCS(=O)(=O)c1cc2c(cc1OC)C(C)(C)c1[nH]c3cc(C#N)ccc3c1C2=O CHEMBL3897705 IC50 1.338 nM
COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2I)n1 CHEMBL3822664 IC50 1.36 nM
CC1(C)c2cc(OC3CCN(CCO)CC3)ccc2C(=O)c2c1[nH]c1cc(C#N)ccc21 CHEMBL3963068 IC50 1.398 nM
CC(C)NC(=O)[C@H]1CC[C@@H](n2/c(=N/C(=O)c3ccc(F)cc3)[nH]c3ccc(CN4CCC(C(N)=O)CC4)cc32)CC1 CHEMBL2172306 IC50 1.4 nM
C[C@@H](Oc1cc(-c2cccc(S(C)(=O)=O)c2)cnc1N)c1cc(F)ccc1-n1nccn1 CHEMBL3286813 Ki 1.4 nM
CCc1cc2c(cc1N1CCN(CC3(O)CCNCC3)CC1)C(C)(C)c1[nH]c3cc(C#N)ccc3c1C2=O CHEMBL3925858 IC50 1.4 nM
COc1cc(Nc2nc(NC3CCOCC3)c(C(C)C)nc2C(N)=O)ccc1N1CCN(C)CC1 CHEMBL3687223 IC50 1.4 nM
COc1cc(-n2cc(CN3CCN(C)CC3)nn2)ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 CHEMBL4174347 IC50 1.4 nM
COc1ccc(NC(=O)CNC(=O)c2ccc(O)c(C(C)C)c2)cc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 CHEMBL4175908 IC50 1.4 nM
CC1(C)c2cc(C3CCN(C4COC4)CC3)ccc2C(=O)c2c1[nH]c1cc(C#N)ccc21 CHEMBL1779202 IC50 1.5 nM
COc1cc(N2CCN(C)CC2)c2cc1Nc1ncc(Cl)c(n1)Nc1cc(ccc1S(=O)(=O)C(C)C)CC2 CHEMBL1946803 IC50 1.5 nM
CC(C)NC(=O)[C@H]1CC[C@@H](n2/c(=N/C(=O)c3ccc(F)cc3)[nH]c3ccc(CN4CC(C(C)(C)O)C4)cc32)CC1 CHEMBL2172312 IC50 1.5 nM
COc1cc2c(cc1Nc1ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n1)CNCCO2 CHEMBL3608525 IC50 1.5 nM
COc1c(Nc2ncc(Cl)c(N[C@H]3[C@@H](C(N)=O)[C@@H]4C=C[C@H]3C4)n2)ccc2c1CCC[C@@H](N1CCOCC1)C2 CHEMBL3908493 IC50 1.5 nM
CCc1cc2c(cc1N1CCN(CC3(O)CCOCC3)CC1)C(C)(C)c1[nH]c3cc(C#N)ccc3c1C2=O CHEMBL3958173 IC50 1.5 nM
CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)c(C)c2)nc1NC1CCOCC1 CHEMBL3687215 IC50 1.5 nM
CC1(C)c2cc(N3CCN(C4CCC4)CC3)c(OC3CCOCC3)cc2C(=O)c2c1[nH]c1cc(C#N)ccc21 CHEMBL3908067 IC50 1.5 nM
COc1c(Nc2nc(Cc3c(Cl)cccc3Cl)c3nc[nH]c3c2C(N)=O)ccc(N2CCNCC2)c1F CHEMBL3950416 Ki 1.5 nM
CNCCc1cc(OC)c(Nc2ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n2)cc1C CHEMBL4091928 IC50 1.5 nM
CNCC(C)(C)c1cc(OC)c(Nc2ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n2)cc1C CHEMBL4089672 IC50 1.5 nM
COc1cc(C(C)(C)N)c(C)cc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 CHEMBL4080869 IC50 1.5 nM
COc1cc(C(C)(C)N(C)C)c(C)cc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 CHEMBL4105099 IC50 1.5 nM
COc1ccc(NC(=O)CNC(=O)c2cc(C(C)C)c(O)cc2O)cc1Nc1ncc(Cl)c(Nc2ccccc2P(C)(C)=O)n1 CHEMBL4172048 IC50 1.5 nM
COc1cc2c(=O)c3c4ccc(C#N)cc4[nH]c3n(C(C)C)c2c(F)c1N1CCN(C)C(C)(C)C1 CHEMBL4778853 IC50 1.5 nM
COc1cc2c(cc1Nc1ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n1)CC[N+](C)(C)C2 CHEMBL4762215 IC50 1.5 nM
CC1(C)c2ccc(N3CCC[C@H]3CN3CCCC3)cc2C(=O)c2c1[nH]c1cc(C#N)ccc21 CHEMBL3891393 IC50 1.57 nM
CC(C)N1CCN(c2ccc(-c3n[nH]c4nc(-c5ccc(O)c(F)c5)ccc34)cc2)CC1 CHEMBL4577227 IC50 1.58 nM
CNS(=O)(=O)c1ccccc1Nc1nc(Nc2cc(N3CCN(C(C)=O)CC3)ccc2OC)ncc1Br CHEMBL1971029 pKi 1.585 nM
COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2C(C)=O)n1 CHEMBL3824301 IC50 1.59 nM
CC(C)NC(=O)[C@H]1CC[C@@H](n2/c(=N/C(=O)c3ccc(F)cc3)[nH]c3ccc(CN4CCNCC4)cc32)CC1 CHEMBL2172333 IC50 1.6 nM
CC(C)NC(=O)[C@H]1CC[C@@H](n2/c(=N/C(=O)c3ccc(F)cc3)[nH]c3ccc(CN4CCCCC4)cc32)CC1 CHEMBL2172330 IC50 1.6 nM
COc1cc2c(cc1Nc1ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n1)CNCCC2 CHEMBL3608523 IC50 1.6 nM
COc1cc2c(cc1Nc1ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n1)CCNCC2 CHEMBL3608524 IC50 1.6 nM
CC(C)Oc1cc2c(cc1O[C@@H]1CCN(C3CCC3)C1)C(C)(C)c1[nH]c3cc(C#N)ccc3c1C2=O CHEMBL4106737 IC50 1.6 nM
COc1cc2c(=O)c3c4ccc(C#N)cc4[nH]c3n(C3CCCCC3)c2cc1N1CCN(C)CC1 CHEMBL4798441 IC50 1.6 nM
COc1cc(N2CCC3(CCN(C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2P(C)(C)=O)n1 CHEMBL5095068 IC50 1.6 nM
C#Cc1cc2c(cc1OC1CCN(C3COC3)CC1)C(C)(C)c1[nH]c3cc(C#N)ccc3c1C2=O CHEMBL3941123 IC50 1.625 nM
CC1(C)c2cc(N3CCC(N4CCC(F)(F)CC4)CC3)ccc2C(=O)c2c1[nH]c1cc(C#N)ccc21 CHEMBL3943227 IC50 1.681 nM
CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2cccc(NC(=O)CN3CCN(C)CC3)c2)ncc1Cl CHEMBL3357456 IC50 1.7 nM
COc1cc2c(cc1Nc1ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n1)CCCNC2 CHEMBL3608522 IC50 1.7 nM
CCc1cc2c(cc1C1=CCN(C(=O)C3CCOCC3)CC1)C(C)(C)c1[nH]c3cc(C#N)ccc3c1C2=O CHEMBL3736388 IC50 1.7 nM
CCc1nc(C(N)=O)c(Nc2cccc(N3CCN(C)CC3)c2)nc1N[C@H]1CC[C@H](O)CC1 CHEMBL3975354 IC50 1.7 nM
CNCc1cc(OC)c(Nc2ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n2)cc1C CHEMBL4067503 IC50 1.7 nM
COc1cc(CCN)c(C)cc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 CHEMBL4081656 IC50 1.7 nM
COc1cc2c(cc1Nc1ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n1)CCC1=NN(C)CCN12 CHEMBL4099922 IC50 1.7 nM
COc1ccc(NC(=O)CNC(=O)c2cc(C(C)C)c(O)cc2O)cc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 CHEMBL4168868 IC50 1.7 nM
COc1cc(N2CCC3(CCN(C)CC3)CC2)c(C)cc1Nc1ncc(Cl)c(Nc2ccccc2P(C)(C)=O)n1 CHEMBL5172847 IC50 1.7 nM
CCCc1cc2c(cc1N1CCN(C3CCC3)CC1)C(C)(C)c1[nH]c3cc(C#N)ccc3c1C2=O CHEMBL3974835 IC50 1.77 nM
CC1(C)c2cc(N3CCC(N4CCCC4)CC3)c(C3=CCNCC3)cc2C(=O)c2c1[nH]c1cc(C#N)ccc21 CHEMBL3937655 IC50 1.778 nM
CC(C)N1CCN(c2ccc3c(c2)C(C)(C)c2[nH]c4cc(C#N)ccc4c2C3=O)CC1 CHEMBL1779200 IC50 1.8 nM
CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2cccc(NC(=O)[C@H](C)N)c2)ncc1Cl CHEMBL3357444 IC50 1.8 nM
CCc1cc2c(cc1N1CCN(CC3(CO)COC3)CC1)C(C)(C)c1[nH]c3cc(C#N)ccc3c1C2=O CHEMBL3736021 IC50 1.8 nM
Cc1cc(-n2cc(C(=O)N(C)C)c3ccc(N[C@@H](C)c4ccc(F)cn4)nc32)[nH]n1 CHEMBL4516801 IC50 1.8 nM
CCN(CC)CC(=O)Nc1n[nH]c2cc(Nc3ncc(Cl)c(Nc4ccccc4S(=O)(=O)C(C)C)n3)ccc12 CHEMBL5180262 IC50 1.8 nM
CCc1cc2c(cc1N1CCN(C3CCC3)CC1)C(C)(C)c1[nH]c3nc(C#N)ccc3c1C2=O CHEMBL3890509 IC50 1.837 nM
COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2C#N)n1 CHEMBL3823864 IC50 1.86 nM
CC1(C)c2cc(N3CCC(NS(C)(=O)=O)CC3)c(Cl)cc2C(=O)c2c1[nH]c1cc(C#N)ccc21 CHEMBL3978878 IC50 1.864 nM
COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2OC)n1 CHEMBL3823045 IC50 1.88 nM
CCc1cc2c(cc1N1CCC(NC3CCCCC3)CC1)C(C)(C)c1[nH]c3cc(C#N)ccc3c1C2=O CHEMBL3911685 IC50 1.891 nM
COc1c(Nc2ncc(Cl)c(N[C@H]3[C@@H](C(N)=O)[C@@H]4C=C[C@H]3C4)n2)ccc2c1CC[C@@H](N1CCOCC1)CC2 CHEMBL2064666 IC50 1.9 nM
CC(C)NC(=O)[C@H]1CC[C@@H](n2/c(=N/C(=O)c3ccc(F)cc3)[nH]c3ccc(CN4CCC(C(C)(C)O)C4)cc32)CC1 CHEMBL2172310 IC50 1.9 nM
Cc1nn(C)c2c1-c1cnc(N)c(c1)OCc1cc(F)ccc1C(=O)N(C)C2 CHEMBL3286822 Ki 1.9 nM
CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)c(C)c2)nc1NC1CCN(C)CC1 CHEMBL3687218 IC50 1.9 nM
COc1cc(CN)c(C)cc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 CHEMBL4070217 IC50 1.9 nM
COc1cc2c(cc1Nc1ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n1)CCN1CCNCC21 CHEMBL4092174 IC50 1.9 nM
Cc1cc(-n2cc(C3=CCOCC3)c3ccc(N[C@@H](C)c4ccc(F)cn4)nc32)[nH]n1 CHEMBL4458269 IC50 1.9 nM
COc1cc(-n2cccc2C(=O)NCCO)ccc1Nc1ncc(Cl)c(Nc2ccccc2NS(C)(=O)=O)n1 CHEMBL4778125 IC50 1.9 nM
C[C@@H](Oc1cc(-c2cnn(C3CC4(CCCNC4)C3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl CHEMBL4114311 IC50 1.92 nM
COc1ccc2c(c1)C(C)(C)c1[nH]c3c(N)c(C#N)ccc3c1C2=O CHEMBL3948122 IC50 1.93 nM
CC(C)NC(=O)[C@H]1CC[C@@H](n2/c(=N/C(=O)c3cccc(Cl)c3)[nH]c3ccc(CN4CCC(C(C)(C)O)CC4)cc32)CC1 CHEMBL2172302 IC50 2.0 nM
CC(C)NC(=O)[C@H]1CC[C@@H](n2/c(=N/C(=O)c3ccc(F)c(F)c3)[nH]c3ccc(CN4CCC(C(C)(C)O)CC4)cc32)CC1 CHEMBL2172319 IC50 2.0 nM
CC(C)NC(=O)[C@H]1CC[C@@H](n2/c(=N/C(=O)c3ccccc3)[nH]c3ccc(CN4CCC(C(C)(C)O)CC4)cc32)CC1 CHEMBL2172313 IC50 2.0 nM
CC(C)NC(=O)[C@H]1CC[C@@H](n2/c(=N/C(=O)c3ccc(F)cc3)[nH]c3ccc(CN4CCC[C@H]4C(N)=O)cc32)CC1 CHEMBL2172307 IC50 2.0 nM
CC(C)NC(=O)[C@H]1CC[C@@H](n2/c(=N/C(=O)c3ccc(F)cc3)[nH]c3ccc(CN4CCC(C(=O)O)CC4)cc32)CC1 CHEMBL2172305 IC50 2.0 nM
CC(C)NC(=O)[C@H]1CC[C@@H](n2/c(=N/C(=O)c3ccc(F)cc3)[nH]c3ccc(CN4CCNC(=O)C4)cc32)CC1 CHEMBL2172334 IC50 2.0 nM
CC(C)NC(=O)[C@H]1CC[C@@H](n2/c(=N/C(=O)c3ccc(F)cc3)[nH]c3ccc(Cn4cncn4)cc32)CC1 CHEMBL2172332 IC50 2.0 nM
CC(C)NC(=O)[C@H]1CC[C@@H](n2/c(=N/C(=O)c3ccc(F)cc3)[nH]c3ccc(CN4CCS(=O)(=O)CC4)cc32)CC1 CHEMBL2172331 IC50 2.0 nM
CC(C)NC(=O)[C@H]1CC[C@@H](n2/c(=N/C(=O)c3ccccc3)[nH]c3ccc(CN4CCCCC4)cc32)CC1 CHEMBL2172328 IC50 2.0 nM
CCNC(=O)[C@H]1CC[C@@H](n2/c(=N/C(=O)c3ccccc3)[nH]c3ccc(CN4CCCCC4)cc32)CC1 CHEMBL2172325 IC50 2.0 nM
COc1ccc(F)cc1[C@@H](C)Oc1cc(-c2c[nH]nc2C)cnc1N CHEMBL3128073 Ki 2.0 nM
Cc1cnc2nc3c(n2c1)-c1cnc(N)c(c1)O[C@H](C)c1cc(F)ccc1C(=O)N(C)C3 CHEMBL3286831 Ki 2.0 nM
Cc1cc(Nc2ncc(Cl)c(Nc3cn(C)nc3S(=O)(=O)C(C)C)n2)c(OC2CC2)cc1CCN(C)C CHEMBL3604652 IC50 2.0 nM
Cc1cc(Nc2ncc(Cl)c(Nc3cn(C)nc3S(=O)(=O)C(C)C)n2)c(OC2CC2)cc1C1CCNCC1 CHEMBL3604633 IC50 2.0 nM
Cc1cc(Nc2ncc(Cl)c(Nc3cn(C)nc3S(=O)(=O)C(C)C)n2)c(OC(C)C)cc1C1CN(C)C1 CHEMBL3604646 IC50 2.0 nM
Cc1cc(Nc2ncc(Cl)c(Nc3cn(C)nc3S(=O)(=O)C(C)C)n2)c(OC2CC2)cc1C1CCN(C(C)C)CC1 CHEMBL3604649 IC50 2.0 nM
Cc1cc(Nc2ncc(C#N)c(Nc3cn(C)nc3S(=O)(=O)C(C)C)n2)c(OC2CC2)cc1C1CCN(C)CC1 CHEMBL3785890 IC50 2.0 nM
Cc1cc(Nc2ncc(F)c(Nc3cn(C)nc3S(=O)(=O)C(C)C)n2)c(OC2CC2)cc1C1CCN(C)CC1 CHEMBL3787598 IC50 2.0 nM
COc1c(Nc2ncc(Cl)c(Nc3ccccc3N(C)S(C)(=O)=O)n2)ccc2c1CCCC(N1CCN(CCO)CC1)C2 CHEMBL3934268 IC50 2.0 nM
CC(C)Oc1cc2c(cc1Nc1ncc(Cl)c(Nc3ccccc3S(=O)(=O)C3CCC3)n1)C(=O)N(C1CCN(C(=O)CN(C)C)CC1)C2 CHEMBL3651835 IC50 2.0 nM
COc1cc(C2CCN(C)CC2)c(C)cc1Nc1nc(Nc2ccccc2S(=O)(=O)C(C)C)c2c(C)[nH]nc2n1 CHEMBL3651862 IC50 2.0 nM
COc1ccccc1-c1c(C(N)=O)sc2cnc(Nc3cc(C)c(N4CCC(N(C)C)C4)cc3OC(C)C)nc12 CHEMBL3669141 IC50 2.0 nM
COc1cc(N2CCN(CCO)CC2)ccc1Nc1ncc(Cl)c(Nc2ccc(N3CCN(C(C)=O)CC3)cc2OC)n1 CHEMBL3973750 IC50 2.0 nM
CCNC(=O)N1CCN(c2ccc(Nc3nc(Nc4ccc(N5CCN(C(C)=O)CC5)cc4OC)ncc3C(F)(F)F)c(OC)c2)CC1 CHEMBL3970685 IC50 2.0 nM
COc1cc(N2CCN(C(C)=O)CC2)ccc1Nc1ncc(C(F)(F)F)c(Nc2ccc(N3CCN(C(=O)CO)CC3)cc2OC)n1 CHEMBL3908581 IC50 2.0 nM
COc1cc(N2CCNCC2)ccc1Nc1nc(Cc2ccccc2Cl)n2ccnc2c1C(N)=O CHEMBL3924329 Ki 2.0 nM
COc1cc(C(=O)N2CCNCC2)ccc1Nc1nc(Cc2c(Cl)cccc2Cl)c2nc[nH]c2c1C(N)=O CHEMBL3935393 Ki 2.0 nM
COc1cc(N2CCN3CCCC3C2)ccc1Nc1nc(Cc2c(Cl)cccc2Cl)c2nc[nH]c2c1C(N)=O CHEMBL3966854 Ki 2.0 nM
CCc1nnc2c(C(N)=O)c(Nc3ccc(C4CCNCC4)cc3Cl)nc(Cc3ccccc3Cl)n12 CHEMBL3926619 Ki 2.0 nM
COc1cc(N2CCNCC2)ccc1Nc1nc(Cc2c(Cl)cccc2Cl)n2c(C)nnc2c1C(N)=O CHEMBL3950825 Ki 2.0 nM
CCc1nnc2c(C(N)=O)c(Nc3ccc(N4CCNCC4)cc3OC)nc(Cc3c(Cl)cccc3Cl)n12 CHEMBL3899654 Ki 2.0 nM
CCc1cn2c(Cc3ccccc3Cl)nc(Nc3ccc(C4CCNCC4)cc3Cl)c(C(N)=O)c2n1 CHEMBL3905111 Ki 2.0 nM
COc1cc(C2CCNCC2)ccc1Nc1nc(Cc2cccc(Cl)c2Cl)n2cnnc2c1C(N)=O CHEMBL3908626 Ki 2.0 nM
NC(=O)c1ccc(N(C(N)=O)c2c(F)cccc2F)nc1-c1ccc(F)cc1F CHEMBL1090090 Kd apparent 2.0 nM
CNC(=O)[C@H]1CC[C@@H](n2/c(=N/C(=O)c3ccccc3)[nH]c3ccc(CN4CCCCC4)cc32)CC1 CHEMBL4476742 IC50 2.0 nM
CCc1cc2c(cc1-c1cnn(CC(=O)N(C)C)c1)C(C)(C)c1[nH]c3cc(C#N)ccc3c1C2=O CHEMBL3735401 IC50 2.0 nM
Cc1cc(-c2cnc3ccc(N[C@@H](C)c4ccc(F)cc4F)nn23)[nH]n1 CHEMBL4562879 IC50 2.0 nM
COc1cc2c(cc1Nc1ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n1)CN(CCO)CC2 CHEMBL4794942 IC50 2.0 nM
CCNC(=O)N1CCc2cc(Nc3ncc(Cl)c(Nc4ccccc4S(=O)(=O)C(C)C)n3)c(OC)cc2C1 CHEMBL4762173 IC50 2.0 nM
COc1cc2c(cc1Nc1ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n1)CCN(C(C)=O)C2 CHEMBL4755723 IC50 2.0 nM
COc1cc(N2CCC3(CCN(C)CC3)CC2)c(F)cc1Nc1ncc(Cl)c(Nc2ccccc2P(C)(C)=O)n1 CHEMBL5185835 IC50 2.0 nM
COc1cc(N2CCC3(CCN(C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2P(C)(C)=S)n1 CHEMBL5178402 IC50 2.0 nM
CN1CCC2(CC1)CCN(c1ccc(Nc3ncc(Cl)c(Nc4ccccc4P(C)(C)=O)n3)c(OC(F)F)c1)CC2 CHEMBL5200942 IC50 2.0 nM
COc1cc(C2CCN(C(=O)CO)CC2)ccc1Nc1ncc(C(F)(F)F)c(Nc2ccc(C3CCN(C(=O)CO)CC3)cc2OC)n1 CHEMBL5275393 IC50 2.0 nM
CCNC(=O)N1CCC(c2ccc3c(c2)C(C)(C)c2[nH]c4cc(C#N)ccc4c2C3=O)CC1 CHEMBL3972824 IC50 2.001 nM
C=Cc1cc2c(cc1N1CCOCC1)C(C)(C)c1[nH]c3cc(C#N)ccc3c1C2=O CHEMBL3892424 IC50 2.052 nM
Cc1cc(Nc2ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n2)c(OC(C)C)cc1C1CCN(C(=O)SCC(=S)N2CCS(=O)(=O)CC2)CC1 CHEMBL5179806 IC50 2.07 nM
CC1(C)c2cc(N3CCN(C4CCC4)CC3)c(Br)cc2C(=O)c2c1[nH]c1cc(C#N)ccc21 CHEMBL3976640 IC50 2.099 nM
CCc1cc2c(cc1C1=CCN(C(=O)C3COCCN3)CC1)C(C)(C)c1[nH]c3cc(C#N)ccc3c1C2=O CHEMBL3735314 IC50 2.1 nM
CCc1cc2c(cc1N1CCN(CC3CCOCC3)CC1)C(C)(C)c1[nH]c3cc(C#N)ccc3c1C2=O CHEMBL3735384 IC50 2.1 nM
COc1ccccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 CHEMBL3822973 IC50 2.1 nM
CC(C)c1nc(C(N)=O)c(Nc2ccc(N3CCN(C)CC3)cc2)nc1N[C@H]1CC[C@H](O)CC1 CHEMBL3687195 IC50 2.1 nM
CC(C)c1nc(C(N)=O)c(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)cc2)nc1NC1CCOCC1 CHEMBL3687221 IC50 2.1 nM
COc1cc(C(C)(C)NC=O)c(C)cc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 CHEMBL4096452 IC50 2.1 nM
COc1cc(CN(C)C)c(C)cc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 CHEMBL4097392 IC50 2.1 nM
CCc1cc2c(=O)c3c4ccc(C#N)cc4[nH]c3n(C(C)C)c2cc1N1CCN(C)CC1 CHEMBL4764107 IC50 2.1 nM
COc1cc(OCC2CCCO2)ccc1Nc1ncc(Cl)c(Nc2ccccc2NS(C)(=O)=O)n1 CHEMBL4748361 IC50 2.1 nM
CNC(=O)c1ccccc1Nc1nc(Nc2ccc3c(NC(=O)CN4CCCC4)n[nH]c3c2)ncc1Cl CHEMBL5204689 IC50 2.1 nM
CC1(C)c2cc(C(=O)NCCNS(N)(=O)=O)ccc2C(=O)c2c1[nH]c1cc(C#N)ccc21 CHEMBL3961470 IC50 2.115 nM
CCc1nc(C(N)=O)c(Nc2ccc(N3CCN(C4CCN(C)CC4)CC3)c(C)c2)nc1NC1CCOCC1 CHEMBL3687225 IC50 2.2 nM
CCOc1cc2c(cc1N1CCC(N3CCOCC3)CC1)C(C)(C)c1[nH]c3cc(C#N)ccc3c1C2=O CHEMBL3983337 IC50 2.2 nM
COc1cc(C(C)(C)CN(C)C)c(C)cc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 CHEMBL4084168 IC50 2.2 nM
COc1cc2c(=O)c3c4ccc(C#N)cc4[nH]c3n(C(C)C)c2c(F)c1N1CCN(C)[C@H](C)C1 CHEMBL4747806 IC50 2.2 nM
C[C@@H](Oc1cc(-c2cnn(C3CC4(CNC4)C3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl CHEMBL4111854 IC50 2.21 nM
CC(C)N1CCC(Cc2ccc3c(c2)C(C)(C)c2[nH]c4cc(C#N)ccc4c2C3=O)CC1 CHEMBL3968909 IC50 2.28 nM
CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2cccc(NC(=O)CN3CC4CC3CN4)c2)ncc1Cl CHEMBL3357460 IC50 2.3 nM
CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2cccc(NC(=O)CN3CCC4CNCC43)c2)ncc1Cl CHEMBL3357463 IC50 2.3 nM
CCc1cc2c(cc1C1=CCN(CC3CCOCC3)CC1)C(C)(C)c1[nH]c3cc(C#N)ccc3c1C2=O CHEMBL3735386 IC50 2.3 nM
COc1c(Nc2ncc(Cl)c(Nc3ccccc3N(C)S(C)(=O)=O)n2)ccc2c1CCCC(N1CCN(C)CC1)C2 CHEMBL3961771 IC50 2.3 nM
COc1c(Nc2ncc(Cl)c(Nc3ccccc3-n3cccn3)n2)ccc2c1CCCC(N1CCN(CCO)CC1)C2 CHEMBL3934099 IC50 2.3 nM
CC(C)S(=O)(=O)c1ccccc1Nc1nc(N/N=C/c2ccc(F)cc2)ncc1Cl CHEMBL3921664 IC50 2.3 nM
Cc1cc(Nc2nc(N[C@H]3CC[C@H](O)CC3)c(Cl)nc2C(N)=O)ccc1N1CCC(N2CCN(C)CC2)CC1 CHEMBL3687217 IC50 2.3 nM
COc1cc(-c2nc(CN3CCN(C)CC3)cs2)ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 CHEMBL4167072 IC50 2.3 nM
CCN1CCN(C(=O)CS(=O)(=O)c2ccc(Nc3ncc(Cl)c(Nc4ccccc4S(=O)(=O)C(C)C)n3)c(OC)c2)CC1 CHEMBL4749215 IC50 2.3 nM
CNC(=O)c1ccccc1Nc1nc(Nc2ccc3c(C(=O)N(C)C)c(C)[nH]c3c2)ncc1Cl CHEMBL5172782 IC50 2.3 nM
C#Cc1cc2c(cc1N1CCOCC1)C(C)(C)c1[nH]c3cc(C#N)ccc3c1C2=O CHEMBL3905916 IC50 2.386 nM
CCc1cc2c(cc1N1CCN(C3CCC3)CC1)C(C)(C)c1[nH]c3cc(C#N)ccc3c1C2=O CHEMBL1940179 IC50 2.4 nM
CCc1cc2c(cc1N1CCN(CC3(O)CC(C)OC(C)C3)CC1)C(C)(C)c1[nH]c3cc(C#N)ccc3c1C2=O CHEMBL3897774 IC50 2.4 nM
CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2cccc(NC(=O)CN3CCNCC3)c2)ncc1Cl CHEMBL3357455 IC50 2.5 nM
C/C(=N\Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1)c1ccc(F)cc1 CHEMBL3922762 IC50 2.5 nM
Cc1cc(-n2cc(C(=O)N3CCOCC3)c3ccc(N[C@@H](C)c4ccc(F)cn4)nc32)[nH]n1 CHEMBL4437605 IC50 2.5 nM
COc1cc(NC(=O)NC2CCC(=O)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2NC(C)=O)n1 CHEMBL4546844 IC50 2.5 nM
COc1cc2c(=O)c3c4ccc(C#N)cc4[nH]c3n(C(C)C)c2c(F)c1C1CCN(C(C)C)CC1 CHEMBL4787453 IC50 2.5 nM
CC(C)Cc1cc2c(=O)c3c4ccc(C#N)cc4[nH]c3n(C(C)C)c2cc1N1CCN(C)CC1 CHEMBL4756825 IC50 2.5 nM
COc1cc(N2CCC(N3CCN(C(=O)CNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2P(C)(C)=O)n1 CHEMBL5084695 IC50 2.5 nM
CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2ccc3c(NC(=O)CN(C)C)n[nH]c3c2)ncc1Cl CHEMBL5192545 IC50 2.5 nM
CNC(=O)c1ccccc1Nc1nc(Nc2ccc3c(NC(=O)CN(C)C)n[nH]c3c2)ncc1Cl CHEMBL5176898 IC50 2.5 nM
CC1(C)c2cc(N3CCOCC3)c(C#CCN3CCOCC3)cc2C(=O)c2c1[nH]c1cc(C#N)ccc21 CHEMBL3904875 IC50 2.575 nM
CC(C)NC(=O)[C@H]1CC[C@@H](n2/c(=N/C(=O)c3ccc(F)cc3)[nH]c3ccc(CN4CCC[C@H]4C(C)(C)O)cc32)CC1 CHEMBL2172309 IC50 2.6 nM
Cc1nc(C2(O)CCS(=O)(=O)C2)sc1-c1cnc(N)c(O[C@H](C)c2cc(F)ccc2-n2nccn2)c1 CHEMBL3128068 Ki 2.6 nM
Cc1nn(C)cc1-c1cnc(N)c(O[C@H](C)c2cc(F)ccc2-n2nccn2)c1 CHEMBL3128075 Ki 2.6 nM
Cc1n[nH]cc1-c1cnc(N)c(O[C@H](C)c2cc(F)ccc2-n2nccn2)c1 CHEMBL3128074 Ki 2.6 nM
CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)c(C)c2)nc1NC1CCC(O)(C(C)C)CC1 CHEMBL3687214 IC50 2.6 nM
CC1(C)c2cc(OC[C@H](O)CO)ccc2C(=O)c2c1[nH]c1c(C3CC3)c(C#N)ccc21 CHEMBL4110481 IC50 2.6 nM
COc1ccc(Nc2ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n2)cc1NC(=O)CNC(=O)c1cc(C(C)C)c(O)cc1O CHEMBL4162252 IC50 2.6 nM
COc1cc2c(=O)c3c4ccc(C#N)cc4[nH]c3n(C(C)C)c2c(F)c1N1C[C@@H](C)N[C@@H](C)C1 CHEMBL4747053 IC50 2.6 nM
COc1cc2c(=O)c3c4ccc(C#N)cc4[nH]c3n(C(C)C)c2c(F)c1N1CCNC(C)(C)C1 CHEMBL4779307 IC50 2.6 nM
COc1cc(SCc2ccc(CN(C)C)o2)ccc1Nc1ncc(Cl)c(Nc2ccccc2NS(C)(=O)=O)n1 CHEMBL4753590 IC50 2.6 nM
CC[C@H]1Nc2ccc3ncc(n3n2)C(=O)NC2(CC2)COc2ccc(F)cc21 CHEMBL5270672 IC50 2.6 nM
C#CC(C)(C)N1CCN(c2cc3c(cc2C(C)=O)C(=O)c2c([nH]c4cc(C#N)ccc24)C3(C)C)CC1 CHEMBL3924183 IC50 2.622 nM
C#Cc1cc2c(cc1N1CCN(C3COC3)CC1)C(C)(C)c1[nH]c3cc(C#N)ccc3c1C2=O CHEMBL1823220 IC50 2.7 nM
CCN1C(=O)CCCc2cc(Nc3ncc(Cl)c(Nc4ccccc4S(=O)(=O)C(C)C)n3)c(OC)cc21 CHEMBL2042983 IC50 2.7 nM
CN1CCN(c2ccc(-c3nc4c(N[C@H]5[C@@H](C(N)=O)[C@@H]6C=C[C@H]5C6)c(Br)cnc4[nH]3)cc2)CC1 CHEMBL3218861 IC50 2.7 nM
CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2cccc(NC(=O)CN)c2)ncc1Cl CHEMBL3357439 IC50 2.7 nM
COc1cc2c(cc1Nc1ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n1)CCCNC2=O CHEMBL3608519 IC50 2.7 nM
COc1cc(N2CCN(CC(=O)N3CCC(=O)CC3)C2=O)ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 CHEMBL4464571 IC50 2.7 nM
COc1cc(NC(=O)N2CCN(CCO)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2NC(C)=O)n1 CHEMBL4468370 IC50 2.7 nM
CN1CCN(Cc2nc3ccc(Nc4ncc(Cl)c(Nc5ccccc5C(=O)N(C)C)n4)cc3[nH]2)CC1 CHEMBL4790721 IC50 2.7 nM
COc1ccc(Cn2ncc(NC(=O)c3cc(NC(=O)Nc4ccc(Cl)c(C(F)(F)F)c4)ccc3C)c2N)cc1 CHEMBL1684800 IC50 2.71 nM
C[C@@H](Oc1cc(-c2cn(C)nc2C#N)cnc1N)c1cc(F)ccc1-n1nccn1 CHEMBL3128058 Ki 2.8 nM
CNC(=O)c1ccc(F)cc1[C@@H](C)Oc1cc(-c2cn(C)nc2C)cnc1N CHEMBL3286809 Ki 2.8 nM
CCc1cc2c(cc1N1CCN(C(=O)C3CNC3)CC1)C(C)(C)c1[nH]c3cc(C#N)ccc3c1C2=O CHEMBL3735650 IC50 2.8 nM
CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)cc2)nc1N[C@H]1CC[C@H](O)CC1 CHEMBL3687194 IC50 2.8 nM
CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)c(C)c2)nc1NC1CCC(O)(CC)CC1 CHEMBL3687213 IC50 2.8 nM
COc1cc(CNC=O)c(C)cc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 CHEMBL4088751 IC50 2.8 nM
COc1cc(SCc2ccc(CN3CCCC3)o2)ccc1Nc1ncc(Cl)c(Nc2ccccc2NS(C)(=O)=O)n1 CHEMBL4741967 IC50 2.8 nM
CCc1cc2c(cc1N1CCN(C3COC3)CC1)C(C)(C)c1[nH]c3cc(C#N)ccc3c1C2=O CHEMBL1823221 IC50 2.9 nM
COc1cc(C2CCN(C[C@H](O)CO)CC2)ccc1Nc1ncc2ccc(-c3ccccc3OC)n2n1 CHEMBL2158531 IC50 2.9 nM
CC1(C)c2cc(OCC3CCN(C4COC4)CC3)ccc2C(=O)c2c1[nH]c1cc(C#N)ccc21 CHEMBL3893380 IC50 2.9 nM
Cc1cc(-n2cc(C(=O)N3CCO[C@@H](C)C3)c3ccc(O[C@@H](C)c4ccc(F)cn4)nc32)n[nH]1 CHEMBL4440381 IC50 2.9 nM
COc1cc(N2CCCC2=O)ccc1Nc1ncc(Cl)c(Nc2ccccc2NC(C)=O)n1 CHEMBL4471142 IC50 2.9 nM
COCCN1CCc2cc(Nc3ncc(Cl)c(N[C@@H]4CCCC[C@H]4N(C)S(C)(=O)=O)n3)c(OC)cc2CC1 CHEMBL1796257 IC50 3.0 nM
COc1cc(C2CCN(CC(O)CF)CC2)ccc1Nc1ncc2ccc(-c3ccccc3OC)n2n1 CHEMBL2158530 IC50 3.0 nM
CC(C)NC(=O)[C@H]1CC[C@@H](n2/c(=N/C(=O)c3ccc(F)c(Cl)c3)[nH]c3ccc(CN4CCC(C(C)(C)O)CC4)cc32)CC1 CHEMBL2172303 IC50 3.0 nM
CC(C)NC(=O)[C@H]1CC[C@@H](n2/c(=N/C(=O)c3cc(F)cc(Cl)c3)[nH]c3ccc(CN4CCC(C(C)(C)O)CC4)cc32)CC1 CHEMBL2172301 IC50 3.0 nM
CC(C)NC(=O)[C@H]1CC[C@@H](n2/c(=N/C(=O)c3cc(F)cc(C#N)c3)[nH]c3ccc(CN4CCC(C(C)(C)O)CC4)cc32)CC1 CHEMBL2172320 IC50 3.0 nM
CC(C)NC(=O)[C@H]1CC[C@@H](n2/c(=N/C(=O)c3ccc(F)cc3)[nH]c3ccc(CN4CCCCC4C(=O)O)cc32)CC1 CHEMBL2172336 IC50 3.0 nM
COC(=O)[C@H]1CC[C@@H](n2/c(=N/C(=O)c3ccccc3)[nH]c3ccc(CN4CCCCC4)cc32)CC1 CHEMBL2172323 IC50 3.0 nM
CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2cccc(NC(=O)CN3CC4CC3CC4O)c2)ncc1Cl CHEMBL3357462 IC50 3.0 nM
COc1cc([C@@H]2CCN(CCO)C[C@@H]2O)ccc1Nc1ncc2ccc(-c3ccccc3OC)n2n1 CHEMBL3398174 IC50 3.0 nM
COc1cc(C2CCN(C)CC2O)ccc1Nc1ncc2ccc(-c3ccccc3OC)n2n1 CHEMBL3398172 IC50 3.0 nM
COc1cc([C@@]2(O)CCN(C)C[C@@H]2O)ccc1Nc1ncc2ccc(-c3ccccc3OC)n2n1 CHEMBL3398166 IC50 3.0 nM
Cc1cc(Nc2ncc(Cl)c(Nc3cn(C)nc3S(=O)(=O)C(C)C)n2)c(OC2CC2)cc1C1CCCN(C)C1 CHEMBL3604656 IC50 3.0 nM
CC(C)S(=O)(=O)c1nn(C)cc1Nc1nc(Nc2ccc(C3CCN(C)CC3)cc2OC2CC2)ncc1Cl CHEMBL3604641 IC50 3.0 nM
CC(C)S(=O)(=O)c1nn(C)cc1Nc1nc(Nc2cc(F)c(C3CCN(C)CC3)cc2OC2CC2)ncc1Cl CHEMBL3604642 IC50 3.0 nM
Cc1cc(Nc2ncc(Cl)c(Nc3cn(C)nc3S(=O)(=O)C(C)C)n2)c(OC2CC2)cc1C1CCS(=O)(=O)CC1 CHEMBL3785607 IC50 3.0 nM
Cc1nc(Nc2nc(Nc3cc(C)c(C4CCN(C)CC4)cc3OC3CC3)ncc2Cl)c(S(=O)(=O)C(C)C)s1 CHEMBL3786916 IC50 3.0 nM
Cc1cc(Nc2ncc(Cl)c(Nc3cn(C)nc3C#N)n2)c(OC2CC2)cc1C1CCN(C)CC1 CHEMBL3786148 IC50 3.0 nM
Cc1cc(Nc2ncc(Cl)c(Nc3cn(C)nc3S(=O)(=O)CC(C)C)n2)c(OC(C)C)cc1C1CCNCC1 CHEMBL3785711 IC50 3.0 nM
O=C(Nc1n[nH]c2ccc(Cc3cc(F)cc(F)c3)cc12)c1ccc(N2CCNCC2)cc1NC1CCOCC1 CHEMBL3805643 IC50 3.0 nM
COc1ncccc1-c1c(C(N)=O)sc2cnc(Nc3cc(C)c(N4CCN(C)CC4)cc3OC(C)C)nc12 CHEMBL3669139 IC50 3.0 nM
COc1cc(N2CCNCC2)ccc1Nc1ncc(C(F)(F)F)c(Nc2ccc(N3CCN(C(C)=O)CC3)cc2OC)n1 CHEMBL3890636 IC50 3.0 nM
COc1cc(N2CCN(CCO)CC2)ccc1Nc1ncc(C(F)(F)F)c(Nc2ccc(N3CCN(C(C)=O)CC3)cc2OC)n1 CHEMBL3950987 IC50 3.0 nM
COc1cc(N2CCNCC2)ccc1Nc1ncc(C(F)(F)F)c(Nc2ccc(N3CCNCC3)cc2OC)n1 CHEMBL3892892 IC50 3.0 nM
COc1cc(N2CCN(C(=O)CO)CC2)ccc1Nc1ncc(C(F)(F)F)c(Nc2ccc(N3CCN(C(=O)CO)CC3)cc2OC)n1 CHEMBL3974726 IC50 3.0 nM
COc1cc(N2CCNCC2)ccc1Nc1ncc(Cl)c(Nc2ccc(N3CCNCC3)cc2OC)n1 CHEMBL3920829 IC50 3.0 nM
COc1cc(N2CCN(C(C)=O)CC2)ccc1Nc1ncc(C(F)(F)F)c(Nc2ccc(N3CCN(C)CC3)cc2OC)n1 CHEMBL3975774 IC50 3.0 nM
COc1cc(N2CCN(C(C)=O)CC2)ccc1Nc1ncc(C(F)(F)F)c(Nc2ccc(N3CCN(S(C)(=O)=O)CC3)cc2OC)n1 CHEMBL3978871 IC50 3.0 nM
COc1cc(N2CCN(C(=O)CO)CC2)ccc1Nc1ncc(C(F)(F)F)c(Nc2ccc(N3CCN(C(C)=O)CC3)cc2OC)n1 CHEMBL3954637 IC50 3.0 nM
COc1cc(N2CCN(C)CC2)ccc1Nc1ncc(C(F)(F)F)c(Nc2ccc(N3CCN(C(C)=O)CC3)cc2OC)n1 CHEMBL3934738 IC50 3.0 nM
COc1cc(C(=O)NCCCCN(C)C)ccc1Nc1nc(Cc2c(Cl)cccc2Cl)n2ccnc2c1C(N)=O CHEMBL3986050 Ki 3.0 nM
COc1cc(-c2nc(CN3CCC(C)CC3)cs2)ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 CHEMBL4159161 IC50 3.0 nM
COc1cc(-n2cc(CN3C[C@@H](C)N[C@@H](C)C3)nn2)ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 CHEMBL4166436 IC50 3.0 nM
COc1cc2c(cc1Nc1ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n1)CN(CC(=O)N(C)C)CC2 CHEMBL4777397 IC50 3.0 nM
COc1cc2c(cc1Nc1ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n1)CN(C)CC2 CHEMBL4754657 IC50 3.0 nM
COc1cc2c(cc1Nc1ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n1)CCN(CC(=O)N(C)C)C2 CHEMBL4740616 IC50 3.0 nM
CCN1CCc2cc(Nc3ncc(Cl)c(Nc4ccccc4S(=O)(=O)C(C)C)n3)c(OC)cc2C1 CHEMBL4765052 IC50 3.0 nM
CNC(=O)c1ccccc1Nc1nc(Nc2ccc3c(C(=O)OC)c(C)[nH]c3c2)ncc1Cl CHEMBL5183055 IC50 3.0 nM
COc1cc(N2CCC3(CC2)CNC3)ccc1Nc1ncc(Cl)c(Nc2ccccc2P(C)(C)=O)n1 CHEMBL5195006 IC50 3.0 nM
COc1ccc2cc1Nc1nc(ncc1Cl)Nc1ccc(N3CCN(C)CC3)c(c1)CC2 CHEMBL1946614 IC50 3.1 nM
COc1c(Nc2ncc(Cl)c(N[C@H]3[C@@H](C(N)=O)[C@@H]4C=C[C@H]3C4)n2)ccc2c1CCC(N1CCN(C)CC1)CC2 CHEMBL2064722 IC50 3.1 nM
CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2cccc(NC(=O)CCN)c2)ncc1Cl CHEMBL3357449 IC50 3.1 nM
CNC(=O)CN1CCN(c2ccc(Nc3ncc(Cl)c(Nc4ccccc4P(C)(C)=O)n3)c(OC)c2)CC1 CHEMBL3823872 IC50 3.1 nM
CC(Oc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl CHEMBL1825138 pKi 3.162 nM
CC1(C)c2cc(N3CCN(S(N)(=O)=O)CC3)ccc2C(=O)c2c1[nH]c1cc(C#N)ccc21 CHEMBL3961322 IC50 3.184 nM
COCc1cn(-c2cc(C)n[nH]2)c2nc(OC(C)c3ccc(F)cn3)ccc12 CHEMBL4434659 IC50 3.2 nM
CN(C)Cc1nc2ccc(Nc3ncc(Cl)c(Nc4ccccc4C(=O)N(C)C)n3)cc2[nH]1 CHEMBL4753667 IC50 3.2 nM
COc1cc(NCC2CCCO2)ccc1Nc1ncc(Cl)c(Nc2ccccc2NS(C)(=O)=O)n1 CHEMBL4787021 IC50 3.2 nM
COC(=O)c1c(C)[nH]c2cc(Nc3ncc(Cl)c(Nc4ccccc4NS(C)(=O)=O)n3)ccc12 CHEMBL5177576 IC50 3.2 nM
COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(C2CC2)c(Nc2ccccc2P(C)(C)=O)n1 CHEMBL3822524 IC50 3.23 nM
Cc1ccc(Oc2ccnc3cc(-c4cnn(C5CCNCC5)c4)ccc23)cc1 CHEMBL4091441 IC50 3.3 nM
CC(C)Oc1ccc(NC(=O)CNC(=O)c2cc(C(C)C)c(O)cc2O)cc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 CHEMBL4170213 IC50 3.3 nM
Cc1cc(-n2cc(S(C)(=O)=O)c3ccc(N[C@@H](C)c4ccc(F)cn4)nc32)n[nH]1 CHEMBL4535072 IC50 3.3 nM
Cc1cc(Nc2ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n2)c(OC(C)C)cc1C1CCN(C(=O)SCC(=S)N2CCN(CCO)CC2)CC1 CHEMBL5178030 IC50 3.3 nM
C=CC(=O)Nc1cc(Nc2ncc(Cl)c(Nc3ccccc3S(=O)(=O)NC3CC3)n2)c(OC)cc1N(C)CCN(C)C CHEMBL5284780 IC50 3.31 nM
CN1CCN(c2ccc3cc2CCc2ccc(N(C)S(C)(=O)=O)c(c2)Nc2nc(ncc2Cl)N3)CC1 CHEMBL1946801 IC50 3.4 nM
COc1cc(C2CCN(C[C@@H](C)O)CC2)ccc1Nc1ncc2ccc(-c3ccccc3OC)n2n1 CHEMBL2158528 IC50 3.4 nM
CC1(C)c2cc(C3CCN(CC4CCOCC4)CC3)ccc2C(=O)c2c1[nH]c1cc(C#N)ccc21 CHEMBL3735648 IC50 3.4 nM
CNC(=O)c1ccccc1Nc1nc(Nc2ccc3c(c2OC)CCCC(N2CCN(CCO)CC2)C3)ncc1Cl CHEMBL3890564 IC50 3.4 nM
COc1cc(C(C)(C)CN)c(C)cc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 CHEMBL4062466 IC50 3.4 nM
CC(C)Oc1cc(-c2nc(CN3CCN(C)CC3)cs2)ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 CHEMBL4163707 IC50 3.4 nM
CN(C)C(=O)c1ccccc1Nc1nc(Nc2ccc3nc(CN4CCCC4)[nH]c3c2)ncc1Cl CHEMBL4746688 IC50 3.4 nM
COc1cc(N2CCC3(CCN(C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccc(F)cc2P(C)(C)=O)n1 CHEMBL5176751 IC50 3.4 nM
CC1(C)c2cc(OC3CCN(CCF)CC3)ccc2C(=O)c2c1[nH]c1cc(C#N)ccc21 CHEMBL3924288 IC50 3.461 nM
CC1(C)c2cc(CN3CCN(S(C)(=O)=O)CC3)ccc2C(=O)c2c1[nH]c1cc(C#N)ccc21 CHEMBL3965185 IC50 3.473 nM
CC1CN(C)CCc2ccc(Nc3ncc(Cl)c(Nc4ccccc4S(=O)(=O)C(C)C)n3)cc21 CHEMBL3263990 IC50 3.5 nM
CC1(C)c2cc(OCC(=O)N3CCNCC3)ccc2C(=O)c2c1[nH]c1cc(C#N)ccc21 CHEMBL3963168 IC50 3.5 nM
CC(C)(CO)NCCOc1ccc2c(c1)C(C)(C)c1[nH]c3cc(C#N)ccc3c1C2=O CHEMBL3916798 IC50 3.595 nM
COc1cc2c(cc1Nc1ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n1)CCC(NC(=O)CN(C)C)C2(C)C CHEMBL3785299 IC50 3.6 nM
CC(C)S(=O)(=O)c1ccccc1Nc1nc(N/N=C/c2ccc(C(F)(F)F)cc2)ncc1Cl CHEMBL3893810 IC50 3.6 nM
CN1CCN(Cc2nc3ccc(Nc4ncc(Cl)c(Nc5ccccc5NS(C)(=O)=O)n4)cc3[nH]2)CC1 CHEMBL4760438 IC50 3.6 nM
CC1(C)c2cc(C(=O)NOCCO)ccc2C(=O)c2c1[nH]c1cc(C#N)ccc21 CHEMBL3928499 IC50 3.611 nM
CN1CCC(Oc2cc3c(cc2N)C(=O)c2c([nH]c4cc(C#N)ccc24)C3(C)C)CC1 CHEMBL3961537 IC50 3.612 nM
CC1(C)c2cc(OCCN3CCS(=O)(=O)CC3)ccc2C(=O)c2c1[nH]c1cc(C#N)ccc21 CHEMBL1779193 IC50 3.7 nM
CC(C)S(=O)(=O)c1ccc2cc1Nc1nc(ncc1Cl)Nc1ccc(N3CCN(C)CC3)c(c1)CC2 CHEMBL1946800 IC50 3.7 nM
COc1cc2c(cc1Nc1ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n1)CCN1C(=O)CNCC21 CHEMBL4081925 IC50 3.7 nM
COc1cc(N2CCN(CC(=O)N(C)C)C2=O)ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 CHEMBL4519408 IC50 3.7 nM
COc1cc(NC(=O)N2CCCC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2NC(C)=O)n1 CHEMBL4448400 IC50 3.7 nM
CCCOc1cc2c(=O)c3c4ccc(C#N)cc4[nH]c3n(C(C)C)c2cc1N1CCN(C)CC1 CHEMBL4749002 IC50 3.7 nM
CN(C)Cc1nc2ccc(Nc3ncc(Cl)c(Nc4ccccc4NS(C)(=O)=O)n3)cc2[nH]1 CHEMBL4747513 IC50 3.7 nM
O=C(Nc1cccc(-n2cc(CNc3ccc(N4CCC(O)CC4)c(C(=O)N4CCCC4)c3)nn2)c1)c1cc(F)cc(F)c1 CHEMBL5285159 IC50 3.7 nM
COc1cc(N2CCN(C[C@@H](C)O)CC2)ccc1Nc1ncc2ccc(-c3ccccc3OC)n2n1 CHEMBL1822521 IC50 3.8 nM
COc1cc(C2CCC3(CC2)CCN(C)CC3)ccc1Nc1ncc(Cl)c(Nc2ccccc2P(C)(C)=O)n1 CHEMBL5179104 IC50 3.8 nM
COc1cc(-n2cc(CN3CCC(C)CC3)nn2)ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 CHEMBL4168473 IC50 3.9 nM
COc1cc2c(=O)c3c4ccc(C#N)cc4[nH]c3n(C(C)C)c2c(F)c1N1CCN[C@H](C)C1 CHEMBL4745824 IC50 3.9 nM
CNC(=O)c1ccccc1Nc1nc(Nc2ccc3c(C(=O)N4CCC(C)CC4)c(C)[nH]c3c2)ncc1Cl CHEMBL5177248 IC50 3.9 nM
N#Cc1ccc2c3c([nH]c2c1)C1(CCOCC1)c1cc(OC2CCNCC2)ccc1C3=O CHEMBL3901152 IC50 3.907 nM
CC1(C)c2ccc(C3=CCN(C4CC4)CC3)cc2C(=O)c2c1[nH]c1cc(C#N)ccc21 CHEMBL3894804 IC50 3.96 nM
Nc1ncnc2c1N=C(c1ccc(NC(=O)Nc3cc(C(F)(F)F)ccc3F)cc1)CCN2 CHEMBL411903 pKi 3.981 nM
CNS(=O)(=O)c1ccccc1Nc1nc(Nc2cc(OC)c(OC)c(OC)c2)ncc1Cl CHEMBL1993661 pKi 3.981 nM
COc1cc(N2CCOCC2)ccc1Nc1ncc(Cl)c(Nc2ccc(N3CCOCC3)cc2OC)n1 CHEMBL1642253 IC50 4.0 nM
COc1cc2c(cc1Nc1ncc(Cl)c(Nc3ccc(N4CCOCC4)cc3OC)n1)CCN(CC(=O)N(C)C)CC2 CHEMBL1642258 IC50 4.0 nM
COc1cc2c(cc1Nc1ncc(Cl)c(Nc3ccccc3OC)n1)CCN(CC(=O)N(C)C)CC2 CHEMBL1642260 IC50 4.0 nM
COCCOc1ccc(Nc2nc(Nc3cc4c(cc3OC)CCN(CC(=O)N(C)C)CC4)ncc2Cl)c(OC)c1 CHEMBL1642263 IC50 4.0 nM
CCN1C(=O)CCCc2cc(Nc3ncc(Cl)c(Nc4ccccc4S(=O)(=O)N(C)C)n3)c(OC)cc21 CHEMBL2042981 IC50 4.0 nM
COCCNC1CCc2cc(Nc3ncc(Cl)c(N[C@H]4[C@@H](C(N)=O)[C@@H]5C=C[C@H]4C5)n3)c(OC)cc2CC1 CHEMBL2064664 IC50 4.0 nM
CN1CCN(c2ccc(-c3nc4c(N[C@H]5[C@@H](C(N)=O)[C@@H]6C=C[C@H]5C6)c(Cl)cnc4[nH]3)cc2)CC1 CHEMBL3218851 IC50 4.0 nM
COc1ccc(F)cc1[C@@H](C)Oc1cc(-c2cnnn2C)cnc1N CHEMBL3286808 Ki 4.0 nM
COc1cc([C@@]2(O)CCNC[C@@H]2O)ccc1Nc1ncc2ccc(-c3ccccc3OC)n2n1 CHEMBL3398169 IC50 4.0 nM
Cc1cc(Nc2ncc(Cl)c(Nc3cn(C)nc3S(=O)(=O)C(C)C)n2)c(OC(C)C)cc1C1CCN(C)C1 CHEMBL3604648 IC50 4.0 nM
CCNC(=O)c1cc(OC2CC2)c(Nc2ncc(Cl)c(Nc3cn(C)nc3S(=O)(=O)C(C)C)n2)cc1C CHEMBL3604655 IC50 4.0 nM
COCCc1cc(OC2CC2)c(Nc2ncc(Cl)c(Nc3cn(C)nc3S(=O)(=O)C(C)C)n2)cc1C CHEMBL3604650 IC50 4.0 nM
Cc1cc(Nc2ncc(Cl)c(Nc3cn(C)nc3S(=O)(=O)C(C)C)n2)c(OC(C)C)cc1C1CCN(C)CC1 CHEMBL3604632 IC50 4.0 nM
CC(C)S(=O)(=O)c1nn(C)cc1Nc1nc(Nc2cc(Cl)c(C3CCN(C)CC3)cc2OC2CC2)ncc1Cl CHEMBL3604643 IC50 4.0 nM
Cc1cc(Nc2ncc(Cl)c(Nc3cn(C)nc3S(=O)(=O)C(C)C)n2)c(OC(C)C)cc1C1CNC1 CHEMBL3604645 IC50 4.0 nM
Cc1cc(Nc2ncc(Cl)c(Nc3cn(C)nc3S(=O)(=O)C(C)C)n2)c(OC(C)C)cc1C1CCNC1 CHEMBL3604647 IC50 4.0 nM
COc1c(Nc2ncc(Cl)c(Nc3ccccc3S(=O)(=O)N(C)C)n2)ccc2c1CCCC(N1CCN(CCO)CC1)C2 CHEMBL3918616 IC50 4.0 nM
COc1ccccc1-c1c(C(N)=O)sc2cnc(Nc3ccc(CN4CCN(C)CC4)cc3OC(C)C)nc12 CHEMBL3669146 IC50 4.0 nM
COc1cc(N2CCN(C(C)=O)CC2)ccc1Nc1ncc(C(F)(F)F)c(Nc2ccc(N3CCNCC3)cc2OC)n1 CHEMBL3899531 IC50 4.0 nM
COc1cc(N2CCN(C(C)=O)CC2)ccc1Nc1ncc(C(F)(F)F)c(Nc2ccc(N3CCN(CCO)CC3)cc2OC)n1 CHEMBL3949819 IC50 4.0 nM
COc1cc(N2CCN(C(=O)CO)CC2)ccc1Nc1ncc(Cl)c(Nc2ccc(N3CCN(C(C)=O)CC3)cc2OC)n1 CHEMBL3931692 IC50 4.0 nM
COc1cc(N2CCN(C(C)=O)CC2)ccc1Nc1ncc(Cl)c(Nc2ccc(N3CCN(C(=O)CO)CC3)cc2OC(F)F)n1 CHEMBL3953919 IC50 4.0 nM
COc1cc(C(=O)NCCCN2CCOCC2)ccc1Nc1nc(Cc2c(Cl)cccc2Cl)n2ccnc2c1C(N)=O CHEMBL3949679 Ki 4.0 nM
COc1cc(C(=O)N2CCN(C)CC2)ccc1Nc1nc(Cc2c(Cl)cccc2Cl)c2nc[nH]c2c1C(N)=O CHEMBL3905248 Ki 4.0 nM
NC(=O)c1c(Nc2ccc(N3CCNCC3)cc2OC(F)(F)F)nc(Cc2c(Cl)cccc2Cl)c2nc[nH]c12 CHEMBL3913589 Ki 4.0 nM
COc1cc(CCNC=O)c(C)cc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 CHEMBL4071105 IC50 4.0 nM
C[C@H]1Oc2cc(cnc2N)-c2c(nn(C)c2C#N)CN(C)C(=O)c2ccccc21 CHEMBL4130209 Ki 4.0 nM
CC(C)Oc1cc(-c2nc(CN3CCN(CCO)CC3)cs2)ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 CHEMBL4160581 IC50 4.0 nM
COc1cc(NC(=O)/C=C/CN2CCN(C)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 CHEMBL4787426 IC50 4.0 nM
COc1cc2c(=O)c3c4ccc(C#N)cc4[nH]c3n(C(C)C)c2c(F)c1N1CCC(N2CCOCC2)CC1 CHEMBL4777376 IC50 4.0 nM
COc1cc2c(cc1Nc1ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n1)CN(C(=O)CO)CC2 CHEMBL4752172 IC50 4.0 nM
Cc1cc(Nc2nc(Nc3ccccc3S(=O)(=O)C(C)C)c3c(C)[nH]nc3n2)c(OC(C)C)cc1C1CCN(C)CC1 CHEMBL3651854 IC50 4.0 nM
COc1ccc(NC(=O)CNC(=O)CN2CCN(Cc3ccc4c(c3)CN(C(=O)c3cc(C(C)C)c(O)cc3O)C4)CC2)cc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 CHEMBL4175858 IC50 4.1 nM
COc1cc(NC(=O)C2CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2NC(C)=O)n1 CHEMBL4462528 IC50 4.1 nM
CC1(C)c2cc(N3CCN(C(=O)C4CC4)CC3)ccc2C(=O)c2c1[nH]c1cc(C#N)ccc21 CHEMBL3961467 IC50 4.2 nM
CC(C)Oc1ccc(NC(=O)CNC(=O)c2cc(C(C)C)c(O)cc2O)cc1Nc1nccc(Nc2ccccc2S(=O)(=O)C(C)C)n1 CHEMBL4176561 IC50 4.2 nM
COc1cc(N2CCNC2=O)ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 CHEMBL4465558 IC50 4.2 nM
C[C@H]1Nc2ccc3ncc(n3n2)C(=O)NC2(CC2)COc2ccc(F)cc21 CHEMBL5273109 IC50 4.2 nM
COc1cc2c(cc1Nc1ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n1)C1CNCC(=O)N1CC2 CHEMBL4071384 IC50 4.3 nM
COc1cc(-n2cc(CN3CCNCC3)nn2)ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 CHEMBL4166038 IC50 4.3 nM
CCN1CCN(CCS(=O)(=O)c2ccc(Nc3ncc(Cl)c(Nc4ccccc4S(=O)(=O)C(C)C)n3)c(OC)c2)CC1 CHEMBL4750810 IC50 4.3 nM
N#Cc1ccc2c3c([nH]c2c1)C1(CCOCC1)c1cc(N2CCN(C4CCC4)CC2)c(F)cc1C3=O CHEMBL3952250 IC50 4.31 nM
C[C@@H](Oc1cc(-c2cnn(C3CCC4(CC3)CNC4)c2)cnc1N)c1c(Cl)ccc(F)c1Cl CHEMBL4109336 IC50 4.31 nM
CC1(C)c2ccc(OC[C@H](O)CO)cc2C(=O)c2c1[nH]c1cc(C#N)ccc21 CHEMBL4107738 IC50 4.338 nM
COc1cc2c(cc1Nc1ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n1)C(=O)NCCC2 CHEMBL3608520 IC50 4.4 nM
CC(C)c1nc(C(N)=O)c(Nc2ccc(N3CCN(C)CC3)cc2)nc1NC1CCOCC1 CHEMBL3687224 IC50 4.5 nM
COc1cc(-n2cccc2C(=O)N2CCSCC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2NS(C)(=O)=O)n1 CHEMBL4779513 IC50 4.5 nM
CCc1cc2c(cc1-c1cnn(CC(O)CO)c1)C(C)(C)c1[nH]c3cc(C#N)ccc3c1C2=O CHEMBL3735510 IC50 4.6 nM
Cc1cc(-n2cc(C(=O)N3CCO[C@H](C)C3)c3ccc(O[C@H](C)c4ccc(F)cn4)nc32)[nH]n1 CHEMBL4573505 IC50 4.6 nM
Cc1cc(Nc2ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n2)c(OC(C)C)cc1C1CCN(C(=O)SCC(=S)N(C)C)CC1 CHEMBL5209011 IC50 4.6 nM
CC(C)N1CCN(c2ccc3c(c2)C(=O)c2c([nH]c4cc(C#N)ccc24)C3(C)C)CC1 CHEMBL3945766 IC50 4.631 nM
COc1cc(C2CCN(CC(N)=O)CC2)ccc1Nc1ncc2c(Cl)cc(-c3ccccc3N(C)S(C)(=O)=O)n2n1 CHEMBL2158519 IC50 4.7 nM
CCc1cc2c(cc1N1CC3CC1CN3CC1CCOCC1)C(C)(C)c1[nH]c3cc(C#N)ccc3c1C2=O CHEMBL3734855 IC50 4.7 nM
COc1cc(N2CCN(CCCN)C2=O)ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 CHEMBL4466920 IC50 4.7 nM
COc1cc(N2CCCNC2=O)ccc1Nc1ncc(Cl)c(Nc2ccccc2NC(C)=O)n1 CHEMBL4536955 IC50 4.7 nM
C[C@H]1Nc2ccc3ncc(n3n2)C(=O)NC2(CCC2)COc2ccc(F)cc21 CHEMBL5269433 IC50 4.7 nM
COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2C(=O)N(C)C)n1 CHEMBL3823016 IC50 4.77 nM
COc1ccc(/C=N/Nc2ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n2)cc1 CHEMBL3894726 IC50 4.8 nM
COc1cc2c(cc1Nc1ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n1)C1CNCCN1CC2 CHEMBL4084421 IC50 4.8 nM
COc1cc2c(=O)c3c4ccc(C#N)cc4[nH]c3n(C(C)C)c2c(F)c1N1CCN(C)[C@@H](C)C1 CHEMBL4741360 IC50 4.8 nM
COc1cc2c(=O)c3c4ccc(C#N)cc4[nH]c3n(C(C)C)c2cc1N1CCN(C)CC1 CHEMBL4755960 IC50 4.8 nM
CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2cccc(NC(=O)CN3CCN(C4COC4)CC3)c2)ncc1Cl CHEMBL3357457 IC50 4.9 nM
COc1ccc(/C(C)=N/Nc2ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n2)cc1 CHEMBL3950479 IC50 4.9 nM
COc1cc2c(=O)c3c4ccc(C#N)cc4[nH]c3n(C(C)C)c2c(F)c1N1CCN[C@@H](C)C1 CHEMBL4797642 IC50 4.9 nM
CCc1ccc2c(c1)c(=O)c(C(=O)Nc1ccc(Oc3ncnc4cc(OC)c(OC)cc34)c(F)c1)c(C)n2C CHEMBL4571241 IC50 4.92 nM
CCc1ccc2c(c1)c(=O)c(C(=O)Nc1ccc(Oc3ncnc4cc(OCCCCCC(=O)Nc5ccc6c(c5)CN(C5CCC(=O)NC5=O)C6=O)c(OC)cc34)c(F)c1)c(C)n2C CHEMBL5394454 IC50 4.94 nM
CC1(C)c2cc(OCCNS(C)(=O)=O)ccc2C(=O)c2c1[nH]c1cc(C#N)ccc21 CHEMBL3893584 IC50 4.943 nM
CNC(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCOCC3)cc2OC)ncc1Cl CHEMBL458997 IC50 5.0 nM
COc1ccc(Nc2nc(Nc3cc4c(cc3OC)CCN(CC(=O)N(C)C)CC4)ncc2Cl)c(OC)c1 CHEMBL1642265 IC50 5.0 nM
COc1cc(N2CCN(C[C@H](C)O)CC2)ccc1Nc1ncc2ccc(-c3ccccc3OC)n2n1 CHEMBL1822520 IC50 5.0 nM
Cc1nnsc1C1=NNC(=O)/C1=C\c1cn(C)c2cccc(OCc3c(F)ccc(Cl)c3F)c12 CHEMBL1922974 IC50 5.0 nM
COc1cc(N2CCN(C)CC2)c2cc1Nc1ncc(Cl)c(n1)Nc1cccc(c1)CC2 CHEMBL1946802 IC50 5.0 nM
CCN1C(=O)CCCc2cc(Nc3ncc(Cl)c(Nc4ccccc4C(=O)NC)n3)c(OC)cc21 CHEMBL2042828 IC50 5.0 nM
CCN1C(=O)CCCc2c1ccc(Nc1ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n1)c2OC CHEMBL2042982 IC50 5.0 nM
C=CCNS(=O)(=O)c1cccc(C(=O)/N=c2\[nH]c3cc(CN4CCCCC4)ccc3n2[C@H]2CC[C@@H](CO)CC2)c1 CHEMBL2172322 IC50 5.0 nM
C[C@@H](Oc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1cc(F)ccc1Cl CHEMBL3128070 Ki 5.0 nM
Cn1ncc2c1-c1cnc(N)c(c1)OCc1cc(F)ccc1OCCCC2 CHEMBL3286817 Ki 5.0 nM
COc1cc([C@H]2CCN(CCO)C[C@@H]2O)ccc1Nc1ncc2ccc(-c3ccccc3OC)n2n1 CHEMBL3398175 IC50 5.0 nM
Cc1cc(Nc2ncc(Cl)c(Nc3cn(C)nc3S(=O)(=O)C(C)C)n2)c(OC2CC2)cc1[C@H]1CC[C@H](NC(C)C)CC1 CHEMBL3785928 IC50 5.0 nM
Cc1cc(Nc2ncc(Cl)c(Nc3cn(C)nc3S(=O)(=O)C(C)C)n2)c(OC2CC2)cc1[C@H]1CC[C@@H](NC(C)C)CC1 CHEMBL3785825 IC50 5.0 nM
COc1c(Nc2ncc(Cl)c(Nc3ccccc3-c3nccn3C)n2)ccc2c1CCCC(N1CCN(CCO)CC1)C2 CHEMBL3961598 IC50 5.0 nM
CC(C)Oc1cc2c(cc1Nc1ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n1)C(=O)N(C1CCN(C(=O)C3CCCN3C)CC1)C2 CHEMBL3651837 IC50 5.0 nM
COc1cc2c(cc1Nc1ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n1)C(=O)N(C1CN(C(=O)[C@@H]3CCCN3C)C1)C2 CHEMBL3651843 IC50 5.0 nM
COc1cc(C2CCN(C(=O)CN(C)C)CC2)c(C)cc1Nc1nc(Nc2ccccc2S(=O)(=O)C(C)C)c2c(C)[nH]nc2n1 CHEMBL3651847 IC50 5.0 nM
COc1cc(N2CCN(C(C)=O)CC2)ccc1Nc1ncc(Cl)c(Nc2ccc(N3CCNCC3)cc2OC(F)F)n1 CHEMBL3972028 IC50 5.0 nM
COc1cc(C(=O)N2CCOCC2)ccc1Nc1nc(Cc2c(Cl)cccc2Cl)n2ccnc2c1C(N)=O CHEMBL3956713 Ki 5.0 nM
COc1cc(C(=O)N2CCN(C)CC2)ccc1Nc1nc(Cc2c(Cl)cccc2Cl)n2ccnc2c1C(N)=O CHEMBL3912006 Ki 5.0 nM
COc1cc2c(cc1Nc1ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n1)CN(C(C)=O)CC2 CHEMBL4764866 IC50 5.0 nM
Cc1cc(Nc2nc(Nc3ccccc3S(=O)(=O)C(C)C)c3c(C)n[nH]c3n2)c(OC(C)C)cc1C1CCNCC1 CHEMBL4762861 IC50 5.0 nM
CNC1CC2OC(C)(C1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL1980995 pKi 5.012 nM
CC1(C)c2cc(OC3CCN(S(C)(=O)=O)CC3)c(Br)cc2C(=O)c2c1[nH]c1cc(C#N)ccc21 CHEMBL3907048 IC50 5.054 nM
C[C@H]1CNC(=O)c2cnc3ccc(nn23)N[C@H](C)c2cc(F)ccc2O1 CHEMBL5274542 IC50 5.1 nM
CN(C)S(=O)(=O)c1cc2c(cc1N1CCN(CCO)CC1)C(C)(C)c1[nH]c3cc(C#N)ccc3c1C2=O CHEMBL3916287 IC50 5.101 nM
CCc1cc2c(cc1N1CCN(C3CC3)CC1)C(C)(C)c1[nH]c3cc(C#N)ccc3c1C2=O CHEMBL1940178 IC50 5.2 nM
COc1cc2c(cc1Nc1ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n1)CCNC(=O)C2 CHEMBL3608521 IC50 5.2 nM
Oc1ccc(Oc2ccnc3cc(-c4cnn(C5CCNCC5)c4)ccc23)cc1 CHEMBL4065208 IC50 5.2 nM
COc1cc2c(=O)c3c4ccc(C#N)cc4[nH]c3n(C3CCCC3)c2cc1N1CCN(C)CC1 CHEMBL4788534 IC50 5.2 nM
CCc1nc(C(N)=O)c(Nc2ccc(N3CCN(C)CC3)cc2)nc1N[C@H]1CC[C@H](O)CC1 CHEMBL3687191 IC50 5.3 nM
COc1cc2c(cc1Nc1ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n1)CCN1C(N)=NCC21 CHEMBL4083964 IC50 5.3 nM
CCC(C)n1c2cc(N3CCN(C)CC3)c(OC)cc2c(=O)c2c3ccc(C#N)cc3[nH]c21 CHEMBL4760756 IC50 5.3 nM
CS(=O)(=O)Nc1ccccc1Nc1nc(Nc2ccc3nc(CN4CCCCC4)[nH]c3c2)ncc1Cl CHEMBL4743188 IC50 5.3 nM
CNC(=O)c1ccccc1Nc1nc(Nc2ccc3c(C(=O)N4CCC(O)CC4)c(C)[nH]c3c2)ncc1Cl CHEMBL5197072 IC50 5.3 nM
CCCCOc1cc2c(=O)c3c4ccc(C#N)cc4[nH]c3n(C(C)C)c2cc1N1CCN(C)CC1 CHEMBL4781855 IC50 5.4 nM
COc1cc(N2CCC(N(C)C)CC2)ccc1Nc1ncc(Cl)c(Nc2cccc3c2B(O)OC3)n1 CHEMBL5268953 IC50 5.4 nM
Cn1cc(-c2ccc3c(c2)C(C)(C)c2[nH]c4cc(C#N)ccc4c2C3=O)cn1 CHEMBL3951557 IC50 5.437 nM
CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2cccc(NC(=O)C(C)(C)N)c2)ncc1Cl CHEMBL3357447 IC50 5.5 nM
CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2cccc(NC(=O)CN3CC4CNCC4C3)c2)ncc1Cl CHEMBL3357464 IC50 5.5 nM
CC(C)S(=O)(=O)c1ccccc1Nc1nc(N/N=C/c2ccc(OC(F)(F)F)cc2)ncc1Cl CHEMBL3913728 IC50 5.5 nM
CC(C)S(=O)(=O)c1ccccc1Nc1nc(N/N=C/c2cccc(C(F)(F)F)c2)ncc1Cl CHEMBL3934594 IC50 5.5 nM
COc1cc2c(=O)c3c4ccc(C#N)cc4[nH]c3n(C(C)C)c2c(F)c1C1CCN(C2COC2)CC1 CHEMBL4776403 IC50 5.5 nM
Cn1cc(-c2cnc3[nH]cc(-c4cnn(Cc5cccc(F)c5)c4)c3c2)cn1 CHEMBL2418752 IC50 5.6 nM
CC1(C)c2cc(C3CCN(CC4COC4)CC3)ccc2C(=O)c2c1[nH]c1cc(C#N)ccc21 CHEMBL3735064 IC50 5.6 nM
CNC(=O)c1ccccc1Nc1nc(Nc2ccc3c(c2OC)CCC[C@@H](N2CCN(CCO)CC2)C3)ncc1Cl CHEMBL3972653 IC50 5.7 nM
Cc1[nH]c2cc(Nc3ncc(Cl)c(Nc4ccccc4NS(C)(=O)=O)n3)ccc2c1C(=O)N1CCOCC1 CHEMBL5174132 IC50 5.7 nM
CC1(C)c2cc(OC3CCNCC3)ccc2C(=O)c2c1[nH]c1cc(C#N)c(F)cc21 CHEMBL3973126 IC50 5.719 nM
C[C@H]1Oc2cc(cnc2N)-c2c(C3CC3)nn(C)c2CN(C)C(=O)c2ccc(F)cc21 CHEMBL3286829 IC50 5.8 nM
COc1c(Nc2ncc(Cl)c(N[C@H]3[C@@H](C(N)=O)[C@@H]4C=C[C@H]3C4)n2)ccc2c1CCC[C@H](N1CCN(CCO)CC1)C2 CHEMBL3972807 IC50 5.8 nM
COc1cc2c(=O)c3c4ccc(C#N)cc4[nH]c3n(C(C)C)c2c(F)c1N1CCC(N(C)C)CC1 CHEMBL4795844 IC50 5.8 nM
CC(C)Oc1cc2c(=O)c3c4ccc(C#N)cc4[nH]c3n(C(C)C)c2cc1N1CCN(C)CC1 CHEMBL4795124 IC50 5.8 nM
COc1cc(N2CCC3(CCNCC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2P(C)(C)=O)n1 CHEMBL5170703 IC50 5.8 nM
O=C(Nc1cccc(-n2cc(CNc3ccc(N4CC(O)C4)c(C(=O)N4CCCCC4)c3)nn2)c1)c1cc(F)cc(F)c1 CHEMBL5280251 IC50 5.8 nM
COc1cc2c(cc1Nc1ncc(Cl)c(Nc3ccc(C(N)=O)cc3OC)n1)CCN(CC(=O)N(C)C)CC2 CHEMBL1642261 IC50 6.0 nM
CNC(=O)CN1CCc2cc(Nc3ncc(Cl)c(Nc4ccc(N5CCOCC5)cc4OC)n3)c(OC)cc2CC1 CHEMBL1642262 IC50 6.0 nM
COCCN1CCc2cc(Nc3ncc(Cl)c(N[C@@H]4CCCC[C@H]4NS(C)(=O)=O)n3)c(OC)cc2CC1 CHEMBL1796254 IC50 6.0 nM
COc1cc2c(cc1Nc1ncc(Cl)c(N[C@H]3[C@@H](C(N)=O)[C@@H]4C=C[C@H]3C4)n1)CCC(N1CCOCC1)CC2 CHEMBL2064667 IC50 6.0 nM
COc1cc(C2CCN(CC(N)=O)CC2)ccc1Nc1ncc2c(C)cc(-c3ccccc3N(C)S(C)(=O)=O)n2n1 CHEMBL2158518 IC50 6.0 nM
COc1cc(C2CCN(CC(N)=O)CC2)ccc1Nc1ncc2ccc(-c3ccccc3OC)n2n1 CHEMBL1934334 IC50 6.0 nM
COc1cc(C2CCN(C)CC2)ccc1Nc1ncc2ccc(-c3ccccc3OC)n2n1 CHEMBL2158529 IC50 6.0 nM
COc1cc(C2CCN(C[C@@H](C)O)CC2)ccc1Nc1ncc2ccc(-c3ccccc3N(C)S(C)(=O)=O)n2n1 CHEMBL2158526 IC50 6.0 nM
COc1cc(C2CCN(CCO)CC2)ccc1Nc1ncc2ccc(-c3ccccc3N(C)S(C)(=O)=O)n2n1 CHEMBL2158525 IC50 6.0 nM
CC(C)NC(=O)[C@H]1CC[C@@H](n2/c(=N/C(=O)c3cccnc3)[nH]c3ccc(CN4CCC(C(C)(C)O)CC4)cc32)CC1 CHEMBL2172318 IC50 6.0 nM
Cc1nn(Cc2cccc(F)c2)cc1-c1c[nH]c2ncc(-c3cnn(C)c3)cc12 CHEMBL2418746 IC50 6.0 nM
Cn1cc(-c2cnc3[nH]cc(-c4cnn(Cc5cc(F)cc(F)c5)c4)c3c2)cn1 CHEMBL2418763 IC50 6.0 nM
COc1cc([C@@]2(O)CCN(CC(N)=O)C[C@@H]2O)ccc1Nc1ncc2ccc(-c3ccccc3OC)n2n1 CHEMBL3398171 IC50 6.0 nM
COc1cc([C@@]2(O)CCNC[C@@H]2O)ccc1Nc1ncc2ccc(-c3ccccc3N(C)S(C)(=O)=O)n2n1 CHEMBL3398168 IC50 6.0 nM
Cc1cc(Nc2ncc(Cl)c(Nc3cn(C)nc3S(=O)(=O)C(C)C)n2)c(OC(F)(F)F)cc1C1CCN(C)CC1 CHEMBL3604638 IC50 6.0 nM
Cc1nc(S(=O)(=O)C(C)C)c(Nc2nc(Nc3cc(C)c(C4CCN(C)CC4)cc3OC3CC3)ncc2Cl)s1 CHEMBL3787297 IC50 6.0 nM
Cc1cc(Nc2ncc(Cl)c(Nc3cn(C4CC4)nc3S(=O)(=O)C(C)C)n2)c(OC(C)C)cc1C1CCNCC1 CHEMBL3786976 IC50 6.0 nM
Cc1cc(Nc2ncc(Cl)c(Nc3cn(C)nc3S(=O)(=O)C(C)C)n2)c(OC(C)C)cc1C1CCNCC1 CHEMBL3604631 IC50 6.0 nM
CC(C)Oc1cc2c(cc1Nc1ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n1)C(=O)N(C1CCN(C(=O)CN(C)C)CC1)C2 CHEMBL3651833 IC50 6.0 nM
COc1cc2c(cc1Nc1ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n1)C(=O)N(C1CN(C(=O)CN(C)C)C1)C2 CHEMBL3651841 IC50 6.0 nM
COc1cc(C2CCOCC2)c(C)cc1Nc1nc(Nc2ccccc2S(=O)(=O)C(C)C)c2c(C)[nH]nc2n1 CHEMBL3651875 IC50 6.0 nM
Cc1cc(Nc2nc(Nc3ccccc3S(=O)(=O)C(C)C)c3c(C)c[nH]c3n2)c(OC(C)C)cc1C1CCN(CCO)CC1 CHEMBL3651882 IC50 6.0 nM
CCNC(=O)N1CCN(c2ccc(Nc3ncc(C(F)(F)F)c(Nc4ccc(N5CCN(C(C)=O)CC5)cc4OC)n3)c(OC)c2)CC1 CHEMBL3944539 IC50 6.0 nM
COc1cc(N2CCN(C(=O)CO)CC2)ccc1Nc1ncc(Cl)c(Nc2ccc(N3CCN(C(=O)CO)CC3)cc2OC)n1 CHEMBL3916883 IC50 6.0 nM
COc1cc(C2CCNCC2)ccc1Nc1nc(Cc2cccc(F)c2F)n2cnnc2c1C(N)=O CHEMBL3964023 Ki 6.0 nM
COc1ccc(NC(=O)CN2CCN(Cc3ccc4c(c3)CN(C(=O)c3cc(C(C)C)c(O)cc3O)C4)CC2)cc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 CHEMBL4167999 IC50 6.0 nM
CC1(C)c2cc(C(=O)N3CCN(C(C)(C)C)CC3)ccc2C(=O)c2c1[nH]c1cc(C#N)ccc21 CHEMBL3937469 IC50 6.002 nM
Cc1c(C#N)ccc2c3c([nH]c12)C(C)(C)c1cc(OC[C@H](O)CO)ccc1C3=O CHEMBL4109094 IC50 6.04 nM
Cc1nc(C(C)(C)O)ccc1-c1cnc(N)c(O[C@H](C)c2cc(F)ccc2-n2nccn2)c1 CHEMBL3128063 Ki 6.1 nM
COc1cc2c(cc1Nc1ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n1)CCC(NC(=O)CO)C2(C)C CHEMBL3786402 IC50 6.1 nM
COc1c(Nc2ncc(Cl)c(Nc3ccccc3N3CCCS3(=O)=O)n2)ccc2c1CCCC(N1CCN(CCO)CC1)C2 CHEMBL3925372 IC50 6.1 nM
COc1cc(C(C)(C)CNC=O)c(C)cc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 CHEMBL4061549 IC50 6.1 nM
Cc1cc(-n2cc(C(=O)N3CCN(C)CC3)c3ccc(N[C@@H](C)c4ccc(F)cn4)nc32)[nH]n1 CHEMBL4586773 IC50 6.1 nM
Cc1cc(Nc2ncc(Cl)c(Nc3ccc4c(c3)B(O)OC4)n2)c(OC(C)C)cc1C1CCNCC1 CHEMBL5283671 IC50 6.1 nM
N#Cc1ccc2c3c([nH]c2c1)C1(CCCC1)c1cc(OC[C@H](O)CO)ccc1C3=O CHEMBL4111362 IC50 6.137 nM
CC1(C)c2cc(OCCN3CCNC3=O)ccc2C(=O)c2c1[nH]c1cc(C#N)ccc21 CHEMBL3922741 IC50 6.159 nM
COc1cccc(/C=N/Nc2ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n2)c1 CHEMBL3905284 IC50 6.2 nM
CCNC(=O)c1noc(-c2cc(C(C)C)c(O)cc2O)c1-c1ccc(CN2CCN(CC(=O)Nc3ccc(OC)c(Nc4ncc(Cl)c(Nc5ccccc5S(=O)(=O)C(C)C)n4)c3)CC2)cc1 CHEMBL4159104 IC50 6.2 nM
Cc1cc(-n2cc(C(=O)N3CCOCC3)c3ccc(OC(C)c4ccc(F)cn4)nc32)[nH]n1 CHEMBL4476859 IC50 6.2 nM
CN1CCC(Oc2cc3c(cc2NS(C)(=O)=O)C(=O)c2c([nH]c4cc(C#N)ccc24)C3(C)C)CC1 CHEMBL3978523 IC50 6.28 nM
COc1c(Nc2ncc(Cl)c(N[C@H]3[C@@H](C(N)=O)[C@@H]4C=C[C@H]3C4)n2)ccc2c1CCC[C@@H](N1CCN(CCO)CC1)C2 CHEMBL3943236 IC50 6.3 nM
C[C@H]1Nc2ccc3ncc(n3n2)C(=O)NC(C)(C)COc2ccc(F)cc21 CHEMBL5284765 IC50 6.4 nM
CCN(CC)CCOc1ccc2c(n1)C(C)(C)c1[nH]c3cc(C#N)ccc3c1C2=O CHEMBL3938910 IC50 6.473 nM
Cc1[nH]c2cc(Nc3ncc(Cl)c(Nc4ccccc4NS(C)(=O)=O)n3)ccc2c1C(=O)N1CCC(C)CC1 CHEMBL5202722 IC50 6.5 nM
C[C@@H]1COc2cn3ncc4c3nc2N1Cc1ccc(F)cc1OCC(C)(C)NC4=O CHEMBL5205937 IC50 6.58 nM
Cc1nn(C)c2c1Cc1cnc(N)c(c1)O[C@H](C)c1cc(F)ccc1C(=O)N(C)C2 CHEMBL4573293 IC50 6.6 nM
CC(C)n1c2[nH]c3cc(C#N)ccc3c2c(=O)c2cc(F)c(N3CCN(C)CC3)c(F)c21 CHEMBL4785020 IC50 6.6 nM
COc1cc(N2CCC3(CNC3)C2)ccc1Nc1ncc(Cl)c(Nc2ccccc2P(C)(C)=O)n1 CHEMBL5172119 IC50 6.6 nM
Cc1cc(Nc2ncc(Cl)c(Nc3cccc4c3B(O)OC4)n2)c(OC(C)C)cc1C1CCNCC1 CHEMBL5266396 IC50 6.6 nM
COc1cc2c(cc1C#CC(=O)O)C(=O)c1c([nH]c3cc(C#N)ccc13)C2(C)C CHEMBL3912544 IC50 6.668 nM
COc1cc(CN2CCOCC2)ccc1-c1nc2c(N[C@H]3[C@@H](C(N)=O)[C@@H]4C=C[C@H]3C4)c(Cl)cnc2[nH]1 CHEMBL3218858 IC50 6.7 nM
COc1cc(N2CCC3(CCNC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2P(C)(C)=O)n1 CHEMBL5184310 IC50 6.7 nM
CC(C)(C)NCCOc1ccc2c(c1)C(C)(C)c1[nH]c3cc(C#N)ccc3c1C2=O CHEMBL3892306 IC50 6.73 nM
CC1(C)c2cc(CN3CCS(=O)(=O)CC3)ccc2C(=O)c2c1[nH]c1cc(C#N)ccc21 CHEMBL3929985 IC50 6.783 nM
CCNC(=O)c1noc(-c2cc(C(C)C)c(O)cc2O)c1-c1ccc(CN2CCN(CC(=O)NCC(=O)Nc3ccc(OC)c(Nc4ncc(Cl)c(Nc5ccccc5S(=O)(=O)C(C)C)n4)c3)CC2)cc1 CHEMBL4169444 IC50 6.9 nM
COCCN1CCc2cc(Nc3ncc(Cl)c(Nc4ccc(N5CCOCC5)cc4OC)n3)c(OC)cc2CC1 CHEMBL1642255 IC50 7.0 nM
COc1cc2c(cc1Nc1ncc(Cl)c(Nc3ccc(C#N)cc3OC)n1)CCN(CC(=O)N(C)C)CC2 CHEMBL1642264 IC50 7.0 nM
CN1CCN(c2ccc(Nc3ncc4ccc(-c5ccccc5N(C)S(C)(=O)=O)n4n3)cc2)CC1 CHEMBL1821735 IC50 7.0 nM
COc1cc(N2CCC(N3CCOCC3)CC2)ccc1Nc1ncc2ccc(-c3ccccc3N(C)S(C)(=O)=O)n2n1 CHEMBL1822527 IC50 7.0 nM
COc1cc(N2CCN(C)CC2)c2cc1Nc1ncc(Cl)c(n1)Nc1cc(ccc1N(C)S(C)(=O)=O)/C=C\2 CHEMBL1947001 IC50 7.0 nM
CCN1C(=O)CCCc2cc(Nc3ncc(Cl)c(N[C@H]4[C@@H](C(N)=O)[C@@H]5C=C[C@H]4C5)n3)c(OC)cc21 CHEMBL2042830 IC50 7.0 nM
COc1cc(C2CCN(C(=O)C(C)(C)N)CC2)ccc1Nc1ncc2ccc(-c3ccccc3OC)n2n1 CHEMBL2158586 IC50 7.0 nM
CC(C)NC(=O)[C@H]1CC[C@@H](n2/c(=N/C(=O)c3ccc(F)cc3)[nH]c3ccccc32)CC1 CHEMBL2172329 IC50 7.0 nM
COc1cc(N2CCOCC2)ccc1-c1nc2c(N[C@H]3[C@@H](C(N)=O)[C@@H]4C=C[C@H]3C4)c(Cl)cnc2[nH]1 CHEMBL3218854 IC50 7.0 nM
CC(=O)N1CCN([C@H]2CC[C@H](c3cc(OC4CC4)c(Nc4ncc(Cl)c(Nc5cn(C)nc5S(=O)(=O)C(C)C)n4)cc3C)CC2)CC1 CHEMBL3787658 IC50 7.0 nM
COc1c(Nc2ncc(Cl)c(N[C@H]3[C@@H](C(N)=O)[C@@H]4C=C[C@H]3C4)n2)ccc2c1CCC[C@H](N1CCOCC1)C2 CHEMBL3945332 IC50 7.0 nM
COCCNC1CCCc2c(ccc(Nc3ncc(Cl)c(N[C@H]4[C@@H](C(N)=O)[C@@H]5C=C[C@H]4C5)n3)c2OC)C1 CHEMBL3951972 IC50 7.0 nM
CCc1cc2c(cc1N1CCN(CC3(O)CCCCC3)CC1)C(C)(C)c1[nH]c3cc(C#N)ccc3c1C2=O CHEMBL3913823 IC50 7.0 nM
Cc1cc(Nc2nc(Nc3ccccc3S(=O)(=O)C(C)C)c3c(C)[nH]nc3n2)c(OC(C)C)cc1C1CCN(C(=O)CN(C)C)CC1 CHEMBL3651848 IC50 7.0 nM
Cc1cc(Nc2nc(Nc3ccccc3S(=O)(=O)C(C)C)c3c(C)c[nH]c3n2)c(OC(C)C)cc1C1CCN(CC(N)=O)CC1 CHEMBL3651880 IC50 7.0 nM
COc1ccccc1-c1c(C(N)=O)sc2cnc(Nc3ccc(C4CCN(C)CC4)cc3OC(C)C)nc12 CHEMBL3669136 IC50 7.0 nM
COc1ccccc1-c1c(C(N)=O)sc2cnc(Nc3cnc(C4CCN(C)CC4)cc3OC(C)C)nc12 CHEMBL3669138 IC50 7.0 nM
COc1cc(N2CCN(C(C)=O)CC2)ccc1Nc1ncc(Cl)c(Nc2ccc(N3CCN(C(C)=O)CC3)cc2Cl)n1 CHEMBL3916647 IC50 7.0 nM
COc1cc(C(=O)NCCN2CCN(C)CC2)ccc1Nc1nc(Cc2c(Cl)cccc2Cl)n2ccnc2c1C(N)=O CHEMBL3900693 Ki 7.0 nM
COc1cc2c(cc1Nc1ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n1)CCN(S(N)(=O)=O)C2 CHEMBL4739896 IC50 7.0 nM
C[C@@H](Oc1cc(-c2ccn(C3CCNCC3)n2)cnc1N)c1c(Cl)ccc(F)c1Cl CHEMBL3734798 IC50 7.0 nM
Cc1cc(Nc2ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n2)c(OC(C)C)cc1C1CCN(C(=O)CCCC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)NCc2ccc(-c3scnc3C)cc2)C(C)(C)C)CC1 CHEMBL4758056 IC50 7.0 nM
CC1(C)c2ccc(OCc3cccnc3)cc2C(=O)c2c1[nH]c1cc(C#N)ccc21 CHEMBL3922786 IC50 7.092 nM
CC1CN(C)CCc2ccc(Nc3ncc(Cl)c(Nc4ccccc4S(=O)(=O)C4CC4)n3)cc21 CHEMBL3263991 IC50 7.1 nM
CCc1cc2c(cc1-c1cnn(CC(N)=O)c1)C(C)(C)c1[nH]c3cc(C#N)ccc3c1C2=O CHEMBL3735980 IC50 7.1 nM
CC1(C)c2cc(CC3CCN(S(N)(=O)=O)CC3)ccc2C(=O)c2c1[nH]c1cc(C#N)ccc21 CHEMBL3939371 IC50 7.278 nM
C[C@@H](Oc1cc(-c2ccnn2C)cnc1N)c1cc(F)ccc1-n1nccn1 CHEMBL3128059 Ki 7.5 nM
CCc1cc2c(cc1N1CCN(C(=O)C3CCCCC3)CC1)C(C)(C)c1[nH]c3cc(C#N)ccc3c1C2=O CHEMBL3945084 IC50 7.5 nM
CCN(CC)CCOc1ccc2c(c1)C(C)(C)c1[nH]c3cc(C#N)ccc3c1C2=O CHEMBL1779192 IC50 7.6 nM
CC1(C)c2cc(OCCNS(N)(=O)=O)ccc2C(=O)c2c1[nH]c1cc(C#N)ccc21 CHEMBL3902372 IC50 7.65 nM
CCCCC1CN(C)CCc2ccc(Nc3ncc(Cl)c(Nc4ccccc4C(=O)NC)n3)cc21 CHEMBL3263972 IC50 7.7 nM
CN(c1ccccc1Nc1nc(Nc2cccc(NC(=O)CN)c2)ncc1Cl)S(C)(=O)=O CHEMBL3357442 IC50 7.7 nM
CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)cc2)nc1NC1CCOCC1 CHEMBL3687220 IC50 7.8 nM
COc1ccc(NC(=O)C(Cc2ccccc2)NC(=O)c2cc(C(C)C)c(O)cc2O)cc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 CHEMBL4174031 IC50 7.8 nM
COc1cc2c(cc1Nc1ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n1)CCN=C2 CHEMBL4777614 IC50 7.8 nM
CNC(=O)c1ccccc1Nc1nc(Nc2ccc3c(c2)C(C)CNCC3)ncc1Cl CHEMBL3263979 IC50 7.9 nM
COc1cc(S(=O)(=O)CC(=O)N2CCN(C)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 CHEMBL4754109 IC50 7.9 nM
CCN1C(=O)CCCc2c1ccc(Nc1ncc(Cl)c(Nc3ccccc3S(=O)(=O)N(C)C)n1)c2OC CHEMBL2042831 IC50 8.0 nM
COc1cc([C@@H]2CCNC[C@@H]2O)ccc1Nc1ncc2ccc(-c3ccccc3OC)n2n1 CHEMBL3397057 IC50 8.0 nM
CC(C)S(=O)(=O)c1nn(C)cc1Nc1nc(Nc2cc(C#N)c(C3CCN(C)CC3)cc2OC2CC2)ncc1Cl CHEMBL3604644 IC50 8.0 nM
CCN(CC)[C@H]1CC[C@@H](c2cc(OC3CC3)c(Nc3ncc(Cl)c(Nc4cn(C)nc4S(=O)(=O)C(C)C)n3)cc2C)CC1 CHEMBL3786173 IC50 8.0 nM
Cc1cc(Nc2ncc(Cl)c(Nc3cn(C)nc3S(=O)(=O)C(C)C)n2)c(OC2CC2)cc1[C@H]1CC[C@@H](NC2CC2)CC1 CHEMBL3786818 IC50 8.0 nM
CCC(C)S(=O)(=O)c1nn(C)cc1Nc1nc(Nc2cc(C)c(C3CCNCC3)cc2OC(C)C)ncc1Cl CHEMBL3785232 IC50 8.0 nM
COc1cc(C2CCN(C(=O)CN(C)C)CC2)c(C)cc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 CHEMBL3651827 IC50 8.0 nM
COc1ncc(F)cc1-c1c(C(N)=O)sc2cnc(Nc3cc(C4CCOCC4)nn3C(C)C)nc12 CHEMBL3669148 IC50 8.0 nM
COc1cc(N2CCN(C(C)=O)CC2)ccc1Nc1ncc(F)c(Nc2ccc(N3CCN(C(=O)CO)CC3)cc2OC(F)F)n1 CHEMBL3924733 IC50 8.0 nM
NC(=O)c1c(Nc2ccc(N3CCNCC3)cc2C(F)(F)F)nc(Cc2c(Cl)cccc2Cl)c2nc[nH]c12 CHEMBL3965445 Ki 8.0 nM
COc1cc(C2CCNCC2)ccc1Nc1nc(Cc2ccccc2F)n2cnnc2c1C(N)=O CHEMBL3941424 Ki 8.0 nM
COc1cc2c(cc1Nc1ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n1)CN(S(N)(=O)=O)CC2 CHEMBL4747624 IC50 8.0 nM
Cc1cc(Nc2nc(Nc3ccccc3S(=O)(=O)C(C)C)c3cc[nH]c3n2)c(OC(C)C)cc1C1CCN(C)CC1 CHEMBL4762256 IC50 8.0 nM
CC1(C)c2cc(OCCN)ccc2C(=O)c2c1[nH]c1cc(C#N)ccc21 CHEMBL3898277 IC50 8.01 nM
Cc1cc(Nc2ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n2)c(OC(C)C)cc1C1CCN(CCO)CC1 CHEMBL2403836 IC50 8.1 nM
COc1cc2c(cc1CCC(C)(C)O)C(=O)c1c([nH]c3cc(C#N)ccc13)C2(C)C CHEMBL3935006 IC50 8.113 nM
CCCC(C)n1c2cc(N3CCN(C)CC3)c(OC)cc2c(=O)c2c3ccc(C#N)cc3[nH]c21 CHEMBL4753546 IC50 8.2 nM
CC(C)NC(=O)[C@H]1CC[C@@H](n2/c(=N/C(=O)c3ccc(F)cc3)[nH]c3ccc(Oc4ccccn4)cc32)CC1 CHEMBL2172337 IC50 8.3 nM
COc1cc(N2CCC(N(C)C)CC2)ccc1Nc1ncc(Cl)c(Nc2ccc3c(c2)B(O)OC3)n1 CHEMBL5271682 IC50 8.4 nM
COCCOc1cc2c(cc1N1CCC(N3CCOCC3)CC1)C(C)(C)c1c(c3ccc(C#N)cc3n1CCOC)C2=O CHEMBL3922510 IC50 8.5 nM
CCN1CCN(C(=O)c2cccn2-c2ccc(Nc3ncc(Cl)c(Nc4ccccc4NS(C)(=O)=O)n3)c(OC)c2)CC1 CHEMBL4756753 IC50 8.5 nM
CN1CCN(c2ccc(NC(=O)[C@@H]3CCCN3c3nc(Nc4cc(F)cc(F)c4)ncc3Cl)cc2C(=O)N(C)C)CC1 CHEMBL4853913 IC50 8.5 nM
O=C(Nc1cccc(-n2cc(CNc3ccc(N4CCC(O)CC4)c(C(=O)N4CCCCC4)c3)nn2)c1)c1cc(F)cc(F)c1 CHEMBL5270423 IC50 8.6 nM
CC1(C)c2cc(N3CCC(N4CCCC4)CC3)c(S(=O)(=O)N3CCCC3)cc2C(=O)c2c1[nH]c1cc(C#N)ccc21 CHEMBL3909864 IC50 8.753 nM
COc1cc(N2CCN(N3CCN(C)CC3)CC2)ccc1Nc1ncc2ccc(-c3ccccc3OC)n2n1 CHEMBL1822523 IC50 8.8 nM
CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)cc2OC)nc1N[C@H]1CC[C@H](O)CC1 CHEMBL3687190 IC50 8.9 nM
COc1cc2c(=O)c3c4ccc(C#N)cc4[nH]c3n(C(C)C)c2c(F)c1N1CCN(C)CC1 CHEMBL4781439 IC50 8.9 nM
CCN1CCc2ccc(Nc3ncc(Cl)c(N[C@@H]4CCCC[C@H]4NS(C)(=O)=O)n3)cc2CC1 CHEMBL1796244 IC50 9.0 nM
COCCN1CCc2ccc(Nc3ncc(Cl)c(N[C@@H]4CCCC[C@H]4NS(C)(=O)=O)n3)cc2CC1 CHEMBL1796245 IC50 9.0 nM
CCN1CCc2ccc(Nc3ncc(Cl)c(N[C@@H]4CCCC[C@H]4NC(C)=O)n3)cc2CC1 CHEMBL1796253 IC50 9.0 nM
COc1cc(N2CCN(C)CC2)ccc1Nc1ncc2ccc(-c3ccccc3OC)n2n1 CHEMBL1822519 IC50 9.0 nM
COc1cc(N2CCN(N3CCOCC3)CC2)ccc1Nc1ncc2ccc(-c3ccccc3OC)n2n1 CHEMBL1822522 IC50 9.0 nM
COc1cc(N2CCN(C)CC2)ccc1Nc1ncc2ccc(-c3ccccc3N(C)S(C)(=O)=O)n2n1 CHEMBL1822524 IC50 9.0 nM
Cn1cc(/C=C2\C(=O)NN=C2c2nccs2)c2c(OCc3c(F)cccc3F)cccc21 CHEMBL1922984 IC50 9.0 nM
COc1cc(N2CCN(C[C@H](C)O)CC2)ccc1Nc1ncc2ccc(-c3ccccc3N(C)S(C)(=O)=O)n2n1 CHEMBL1822525 IC50 9.0 nM
COCCN[C@@H]1CCc2ccc(Nc3ncc(Cl)c(N[C@H]4[C@@H](C(N)=O)[C@@H]5C=C[C@H]4C5)n3)c(OC)c2CC1 CHEMBL2064663 IC50 9.0 nM
COc1cc(C2CCN(CC(N)=O)CC2)ccc1Nc1ncc2ccc(-c3ccncc3OC)n2n1 CHEMBL2158515 IC50 9.0 nM
CNC(=O)c1ccccc1Nc1nc(Nc2ccc3c(c2)C(C)CN(C)CC3)ncc1Cl CHEMBL3263971 IC50 9.0 nM
C[C@@H](Oc1cc(-c2cnnn2C)cnc1N)c1cc(F)ccc1-n1nccn1 CHEMBL3128060 Ki 9.0 nM
CC(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2cccc(NC(=O)CN3CCN(C(=O)CO)CC3)c2)ncc1Cl CHEMBL3357459 IC50 9.0 nM
Cc1cc(Nc2ncc(Cl)c(Nc3cn(C)nc3S(=O)(=O)C(C)C)n2)c(OC2CC2)cc1S(C)(=O)=O CHEMBL3604654 IC50 9.0 nM
CCN(CC)[C@H]1CC[C@H](c2cc(OC3CC3)c(Nc3ncc(Cl)c(Nc4cn(C)nc4S(=O)(=O)C(C)C)n3)cc2C)CC1 CHEMBL3785934 IC50 9.0 nM
Cc1cc(Nc2ncc(Cl)c(Nc3cn(C)nc3S(=O)(=O)C(C)C)n2)c(OC2CC2)cc1[C@H]1CC[C@H](NC2CC2)CC1 CHEMBL3785665 IC50 9.0 nM
Cc1cc(Nc2ncc(Cl)c(Nc3cn(C)nc3S(=O)(=O)C(C)C)n2)c(OC2CC2)cc1C1CCOCC1 CHEMBL3786171 IC50 9.0 nM
CN1CCC(Oc2ccc(C(=O)Nc3n[nH]c4ccc(Cc5cc(F)cc(F)c5)cc34)c(NC3CCOCC3)c2)CC1 CHEMBL3806122 IC50 9.0 nM
COc1c(Nc2ncc(Cl)c(N[C@H]3[C@@H](C(N)=O)[C@@H]4C=C[C@H]3C4)n2)ccc2c1CCC[C@H](N1CCN(C)CC1)C2 CHEMBL3936443 IC50 9.0 nM
COc1c(Nc2ncc(Cl)c(N[C@H]3[C@@H](C(N)=O)[C@@H]4C=C[C@H]3C4)n2)ccc2c1CCC[C@@H](N1CCN(C)CC1)C2 CHEMBL3980825 IC50 9.0 nM
Cc1cc(Nc2nc(Nc3ccccc3S(=O)(=O)C(C)C)c3c(C)c[nH]c3n2)c(OC(C)C)cc1C1CCN(C)CC1 CHEMBL3651881 IC50 9.0 nM
COc1cc(N2CCN(C(C)=O)CC2)ccc1Nc1ncc(C(F)(F)F)c(Nc2ccc(N3CCN(C(C)=O)CC3)cc2OC)n1 CHEMBL3919579 IC50 9.0 nM
COc1cc(N2CCN(C(C)=O)CC2)ccc1Nc1ncc(Cl)c(Nc2ccc(N3CCNCC3)cc2OC)n1 CHEMBL3925957 IC50 9.0 nM
COc1cc(N2CCN(S(N)(=O)=O)CC2)ccc1Nc1ncc(Cl)c(Nc2ccc(N3CCN(C(C)=O)CC3)cc2OC)n1 CHEMBL3945192 IC50 9.0 nM
COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2cccc3c2B(O)OC3)n1 CHEMBL5269028 IC50 9.1 nM
CN1CCN(c2ccc(NC(=O)[C@@H]3CCCN3c3nc(Nc4cc(F)cc(F)c4)ncc3Cl)cc2C(=O)N2CCSCC2)CC1 CHEMBL4854103 IC50 9.3 nM
CC(C)C1(N2CCOCC2)CCN(c2cc3c(cn2)C(=O)c2c([nH]c4cc(C#N)ccc24)C3(C)C)CC1 CHEMBL3916733 IC50 9.37 nM
COc1cc2c(cc1SC(C)C)C(=O)c1c([nH]c3cc(C#N)ccc13)C2(C)C CHEMBL3949427 IC50 9.451 nM
CCc1cc2c(cc1N1CCC(N(C)C3COC3)CC1)C(C)(C)c1[nH]c3cc(C#N)ccc3c1C2=O CHEMBL3735531 IC50 9.5 nM
CCS(=O)(=O)c1cn(-c2cc(C)[nH]n2)c2nc(N[C@@H](C)c3ccc(F)cn3)ccc12 CHEMBL4443254 IC50 9.6 nM
CNC(=O)c1ccccc1Nc1nc(Nc2ccc(-n3cccc3C(=O)NCCO)cc2OC)ncc1Cl CHEMBL4758571 IC50 9.6 nM
CC1(C)c2cc(OC3CCOCC3)c(S(=O)(=O)N3CCOCC3)cc2C(=O)c2c1[nH]c1cc(C#N)ccc21 CHEMBL3980776 IC50 9.617 nM
C=CC[C@H]1Nc2ccc3ncc(n3n2)C(=O)NC2(CC2)COc2ccc(F)cc21 CHEMBL5279319 IC50 9.7 nM
COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2)n1 CHEMBL3824185 IC50 9.9 nM
COCCOc1cc2c(cc1OC(C)C)C(=O)c1c(n(CCOC)c3cc(C#N)ccc13)C2(C)C CHEMBL3975525 IC50 9.9 nM