C=C(C)C(O)/C=C/c1ccc(OC)cc1 CHEMBL1515352 Potency 1.0 nM
O=C(Nc1ccc(F)cc1Cl)c1n[nH]c(Cl)c1Br CHEMBL3604156 IC50 1.0 nM
CCN([C@H]1CCN(C(C)c2ccc(F)cc2)C1)S(=O)(=O)NCCc1c(-c2cccs2)n[nH]c1-c1cnccn1 CHEMBL3622746 Ki 1.0 nM
Clc1ccc2nc(-c3n[nH]c(Cl)c3Cl)oc2c1 CHEMBL3604185 IC50 2.0 nM
Nc1nc(O)c2[nH]nnc2n1 CHEMBL374107 Potency 3.2 nM
Clc1ccc2nc(-c3cc(Cl)[nH]n3)oc2c1 CHEMBL3604184 IC50 4.0 nM
NCCCCCC(=O)O CHEMBL1046 Potency 5.0 nM
Oc1nc(CSc2nc3ccccc3o2)nc2c1cnn2-c1ccccc1 CHEMBL1406016 Potency 5.0 nM
O=C(COc1ccc(Cl)cc1Cl)Nc1noc2ccccc12 CHEMBL1419647 Potency 6.3 nM
C[C@@](N)(Cc1ccc(O)cc1)C(=O)O CHEMBL1368961 Potency 6.3 nM
Cc1ccc(NC(=O)CN2C(=O)NC(Cc3ccccc3)C2=O)cc1 CHEMBL1565492 Potency 6.3 nM
CCCCN(CC)C(=O)C1CCC(=O)N(c2ccc(OC)cc2)C1c1ccc(OC)c(OC)c1 CHEMBL1466511 Potency 6.3 nM
CC12CS(=O)(=O)CC1SC(=S)N2c1ccccn1 CHEMBL1302560 Potency 6.3 nM
CC(C)NC[C@H](O)c1ccc(O)c(O)c1 CHEMBL2062275 Potency 6.3 nM
Cc1nc(O)nc(O)c1S(=O)(=O)N1CCCC(C(=O)N2CCN(c3ccccc3Cl)CC2)C1 CHEMBL1303685 Potency 6.3 nM
COc1ccc(C2C(C(=O)N3CCC4(CC3)OCCO4)c3cc(OC)c(OC)cc3C(=O)N2C)cc1 CHEMBL1524581 Potency 6.3 nM
Cc1cc(C)c(C(=O)COC(=O)Cn2cnnn2)cc1C CHEMBL1463242 Potency 6.3 nM
CN1CCCCC/C1=N/C1=C(C#N)CCCC1 CHEMBL3194428 Potency 6.3 nM
O=C(COn1nnc2ccccc21)NCC1CCCCC1 CHEMBL1311629 Potency 6.3 nM
COC(=O)C1=C(C)OC(N)=C(C#N)C1c1cc(OC)c(OCC(N)=O)cc1Cl CHEMBL1331287 Potency 6.3 nM
O=C(Oc1ccc2c(c1)OCO2)c1cccs1 CHEMBL1509915 Potency 6.3 nM
N#CC[N+]1(Cc2ccccn2)CCCC1 CHEMBL1790030 Potency 6.3 nM
CCN(CC)c1ccc(NC(=O)C2CCCN(S(=O)(=O)c3c[nH]cn3)C2)c(C)c1 CHEMBL1404006 Potency 7.9 nM
CC(=O)NC1CCC(C(=O)O)(c2ccccc2)C1 CHEMBL1377260 Potency 7.9 nM
O=C(N/N=C1/C[C@@H](O)[C@@H](O)[C@@H]2[C@@H]3C(=O)N(C[C@@H]4CCCO4)C(=O)[C@H]3CC[C@H]12)OCc1ccccc1 CHEMBL1592468 Potency 7.9 nM
CCC1C(=O)n2nc(-c3ccccc3)cc2N=C1C CHEMBL1378090 Potency 7.9 nM
O=C(O)CCCNc1cc(N2CCC3(CC2)OCCO3)c2noc3c2c1C(=O)c1ccccc1-3 CHEMBL1309430 Potency 7.9 nM
CC(N)=O CHEMBL16081 Potency 7.9 nM
CCC(C)(C)n1nnnc1CN(Cc1ccco1)Cc1cc2cc3c(cc2nc1O)OCO3 CHEMBL1548983 Potency 7.9 nM
CC(C)N(CC[C@@](C(N)=O)(c1ccccc1)c1ccccn1)C(C)C CHEMBL269362 Potency 10.0 nM
Cc1ccccc1OCC(O)CN CHEMBL1387552 Potency 10.0 nM
Cc1cccc(OCc2nnc(S)o2)c1 CHEMBL1303091 Potency 10.0 nM
CC1CCCCC1NC(=O)COc1ccc(-n2cnnn2)cc1 CHEMBL1344239 Potency 10.0 nM
O=C(Nc1ccc(C2CCCCC2)cc1)C1CCN(c2ncccn2)CC1 CHEMBL1389294 Potency 10.0 nM
C=CCn1sc(N)c(C#N)c1=N CHEMBL1586577 Potency 10.0 nM
Cn1c(-c2ccc(N)cc2)nc2ccccc21 CHEMBL1503644 Potency 10.0 nM
CCOC(=O)c1cccc(NC(=O)CSc2nnc(C3CCCCC3)n2CC)c1 CHEMBL1407493 Potency 10.0 nM
O=C(OCC#CCSc1nnc(-c2cccc3ccccc23)o1)c1ccc(F)cc1 CHEMBL1271117 Ki 10.0 nM
Cc1ccc(S(=O)(=O)Nc2c(C)n(C)n(-c3ccccc3)c2=O)cc1C(=O)NCc1ccccn1 CHEMBL1368759 Potency 12.6 nM
CC(C)=CC(=O)OCC(=O)NC(=O)NC(C)(C)C CHEMBL1438937 Potency 12.6 nM
CN(CC(=O)NCc1ccc2c(c1)OCO2)S(=O)(=O)c1ccc(Br)s1 CHEMBL1526784 Potency 12.6 nM
CC(=O)c1ccc(OCCCC(=O)n2nnc3ccccc32)cc1 CHEMBL1583856 Potency 12.6 nM
COc1cc2c(cc1OC)C(C(=O)Nc1cccc(C)n1)C(c1cccnc1)N(C)C2=O CHEMBL1571970 Potency 12.6 nM
COc1cc(/C=C/c2cc(/C=C/c3cc(CC=C(C)C)c(O)c(OC)c3)[nH]n2)cc(CC=C(C)C)c1O CHEMBL3290441 IC50 13.0 nM
Clc1ccc2nc(-c3cc[nH]n3)oc2c1 CHEMBL3604180 IC50 13.0 nM
O=C(Nc1ccc(F)cc1Cl)c1n[nH]c(Cl)c1Cl CHEMBL3604153 IC50 14.0 nM
O=C(OCC#CCSc1nnc(-c2cccc3ccccc23)o1)c1cc2ccccc2o1 CHEMBL1270705 Ki(app) 15.0 nM
CN(C)c1ccc(C(=O)OCC#CCSc2nnc(-c3cccc4ccccc34)o2)cc1 CHEMBL1269897 Ki(app) 15.0 nM
COC(=O)C1CCN(C(=O)CSc2nnc(-c3ccncc3)o2)CC1 CHEMBL1386213 Potency 15.8 nM
Cc1cc2c(c(=O)o1)C1(C(=O)N(C)c3ccccc31)C(C#N)=C(N)O2 CHEMBL1304690 Potency 15.8 nM
O=C1CCCC=C1[C@@H](O)COCc1ccccc1 CHEMBL1323167 Potency 15.8 nM
C/C(=C(\C#N)P(=O)(c1ccccc1)c1ccccc1)N1CCCC1 CHEMBL1463899 Potency 15.8 nM
C[Se]C[C@@H](N)C(=O)O CHEMBL1472699 Potency 15.8 nM
O=C(OCC#CCSc1nnc(-c2cccc3ccccc23)o1)c1cc(F)c(F)c(F)c1 CHEMBL1271321 Ki(app) 16.0 nM
O=C(Nc1ccc(F)cc1Cl)c1ccn(C(=S)Nc2ccc3c(c2)OCO3)n1 CHEMBL3597768 IC50 17.0 nM
O=C(OCC#CCSc1nnc(-c2cccc3ccccc23)o1)c1cccs1 CHEMBL1270217 Ki(app) 19.0 nM
COc1ccc(NC(=O)CCN2CCCCC2)cc1 CHEMBL1328649 Potency 20.0 nM
CCc1nnc(NC(=O)CSc2nnc(COc3ccc(C#N)cc3)n2-c2ccccc2)s1 CHEMBL1320440 Potency 20.0 nM
Cc1cc(C)c2c(=O)n(CC(=O)NCCCN3CCOCC3)sc2n1 CHEMBL1499996 Potency 20.0 nM
COCCOC(=O)C1=C(C)NC(=O)NC1c1c(F)cccc1Cl CHEMBL1462633 Potency 20.0 nM
O=C(Nc1ccc(CCC(=O)N2CCCC2)cc1)c1nc[nH]n1 CHEMBL1413699 Potency 20.0 nM
CCCCCc1ccc(S(=O)(=O)NCCc2c(-c3cc4ccccc4o3)[nH]c3ccccc23)cc1 CHEMBL179335 Ki 21.0 nM
O=C(OCC#CCSc1nnc(-c2cccc3ccccc23)o1)c1ccc2ccccc2c1 CHEMBL1270704 Ki(app) 22.0 nM
O=C(Nc1ccc(F)cc1Cl)c1cc(Cl)[nH]n1 CHEMBL3604152 IC50 22.0 nM
O=C(OCC#CCSc1nnc(-c2cc3ccccc3[nH]2)o1)c1ccc(F)cc1 CHEMBL1270914 Ki(app) 23.0 nM
O=C(Nc1ccc(F)cc1Cl)c1cc[nH]n1 CHEMBL3604132 IC50 24.0 nM
COc1ccc(CCN(C)CCCN2CCc3cc(OC)c(OC)cc3CC2=O)cc1OC CHEMBL543767 Potency 25.1 nM
Cc1noc(C)c1COC(=O)c1cc2c3ccccc3n(C)c2s1 CHEMBL1511524 Potency 25.1 nM
COCCNC(=O)C(c1ccc(C)o1)N(Cc1cccs1)C(=O)c1snc(C(N)=O)c1N CHEMBL1301192 Potency 25.1 nM
CC(CS(=O)(=O)c1cccc2cccnc12)N1CCCCC1 CHEMBL1504507 Potency 25.1 nM
O=C(NCc1cccs1)C1CCN(S(=O)(=O)c2ccc3c(c2)OCCO3)CC1 CHEMBL1369599 Potency 25.1 nM
Cc1cccc(-n2c(SCC(=O)Nc3nonc3C)nnc2-c2ccoc2C)c1 CHEMBL1460835 Potency 25.1 nM
O=C(C1CCN(S(=O)(=O)c2ccc3c(c2)OCCO3)CC1)N1CCc2ccccc21 CHEMBL1329843 Potency 25.1 nM
CC(=O)N[C@@H](CS)C(=O)O CHEMBL600 Potency 25.1 nM
CCN1C(=O)c2cccc3c(S(=O)(=O)Nc4ncccc4C)ccc1c23 CHEMBL1462847 Potency 25.1 nM
O=C(OCC#CCSc1nnc(-c2ccccc2)o1)c1ccc(F)cc1 CHEMBL1270412 Ki(app) 26.0 nM
O=C(OC/C=C/CSc1nnc(-c2cccc3ccccc23)o1)c1ccc(F)cc1 CHEMBL1271222 Ki(app) 26.0 nM
O=C(Nc1ccc(Cl)cn1)c1cc[nH]n1 CHEMBL3604138 IC50 26.0 nM
O=C(OCC#CCSc1nnc(-c2cccc3ccccc23)o1)c1cccc(C(F)(F)F)c1 CHEMBL1270219 Ki(app) 27.0 nM
O=C(Nc1ccc(F)cc1Cl)c1cc(I)[nH]n1 CHEMBL3604158 IC50 27.0 nM
CCOC(=O)c1[nH]c2cc(Cl)ccc2c1C(=O)C[C@@H](C)CCCC(C)C CHEMBL3622735 Ki 30.0 nM
O=C(OCC#CCSc1nnc(-c2cccc3ccccc23)o1)c1sc2ccccc2c1Cl CHEMBL1270913 Ki(app) 31.0 nM
CCOc1ccc2nc(O)c(CN(CCO)C(=O)CC)cc2c1 CHEMBL1573914 Potency 31.6 nM
CCc1ccc2nc(O)c(C(c3nnnn3CCOC)N3CCN(c4ccccc4)CC3)cc2c1 CHEMBL1441425 Potency 31.6 nM
CC(C)(C)OC(=O)N1CC=C2C(C#N)=C(N)C(C#N)(C#N)C(c3cccs3)C2C1 CHEMBL1428977 Potency 31.6 nM
COc1ccc(-c2cc(-c3cccs3)c(C#N)c(SCC(=O)NCc3ccco3)n2)cc1 CHEMBL1390198 Potency 31.6 nM
CCSc1nnc(-c2ccccc2NC(=O)CC)c(O)n1 CHEMBL1327315 Potency 31.6 nM
Oc1nc2c(cc1CNCCN1CCOCC1)c(-c1cccc(F)c1)nn2-c1ccccc1 CHEMBL1375781 Potency 31.6 nM
C=CCn1c(COc2ccc(CC)cc2)nnc1SCC(=O)N(C)C1CCS(=O)(=O)C1 CHEMBL1403500 Potency 31.6 nM
CS(=O)(=O)c1ccc(C(=O)OCC#CCSc2nnc(-c3cccc4ccccc34)o2)cc1 CHEMBL1270003 Ki(app) 33.0 nM
O=C(Nc1ccc(F)cc1Cl)c1n[nH]cc1Cl CHEMBL3604151 IC50 33.0 nM
CCCCCCCCOC(=O)NS(=O)(=O)Nc1cc(-c2cc3ccccc3[nH]2)ccc1OC CHEMBL5089414 IC50 33.0 nM
O=C(Nc1ccc(F)cc1Cl)c1n[nH]c(C(F)(F)F)c1Cl CHEMBL3604162 IC50 37.0 nM
O=C(Nc1ccc(F)cc1Cl)c1n[nH]cc1Br CHEMBL3604155 IC50 39.0 nM
O=C(Nc1ccc(F)cc1Cl)c1n[nH]c(C(F)F)c1Cl CHEMBL3604164 IC50 39.0 nM
CC(CN1CCCCC1)OC(=O)c1ccc(Cl)cc1 CHEMBL1370517 Potency 39.8 nM
Cc1cc(N)n2ncc(-c3ccccc3)c2n1 CHEMBL1300779 Potency 39.8 nM
CCCN1CCN(C(c2cc3cc(OC)ccc3nc2O)c2nnnn2C2CCCCC2)CC1 CHEMBL1565594 Potency 39.8 nM
C=CCNc1ncnc2c1ncn2C1OC(CO)C(O)C1O CHEMBL46703 Potency 39.8 nM
COC(=O)[C@H]1C(=O)c2ccccc2O[C@@](C(=O)OC)(c2ccccc2)[C@@H]1c1ccccc1 CHEMBL1531163 Potency 39.8 nM
CCN1CCN(C(c2cccs2)C(C)NC(=O)c2cccc(OC)c2OC)CC1 CHEMBL1602312 Potency 39.8 nM
Cc1cc(C)c2c(=O)n(CC(=O)N3CCC(Cc4ccccc4)CC3)sc2n1 CHEMBL1367163 Potency 39.8 nM
Cc1cccc(N2CCN(C(=O)Cn3sc4nc(C)cc(C)c4c3=O)CC2C)c1 CHEMBL1481546 Potency 39.8 nM
CCn1c(CSc2nnc(-c3ccc4c(c3)OCO4)o2)nc2cc(S(=O)(=O)N(C)C)ccc21 CHEMBL1503863 Potency 39.8 nM
O=C(Nc1ccc(F)cc1Cl)c1n[nH]cc1F CHEMBL3604154 IC50 42.0 nM
CC(C)(C)c1cc(C(=O)Nc2ccc(F)cc2Cl)n[nH]1 CHEMBL3604149 IC50 42.0 nM
O=C(OCC#CCSc1nnc(-c2ccccc2F)o1)c1ccc(F)cc1 CHEMBL1270413 Ki(app) 43.0 nM
O=C(Nc1ccc(F)cc1Cl)c1ccn(C(=O)Nc2ccc3c(c2)OCO3)n1 CHEMBL3597764 IC50 47.0 nM
O=C(Nc1ccccc1)c1cc[nH]n1 CHEMBL445420 IC50 47.0 nM
Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(N)(=O)=O)cc2)cc1 CHEMBL118 IC50 49.0 nM
CCOC(=O)C1=C(C)OC(N)=C(C#N)C1c1c(C)nn(-c2ccccc2)c1Cl CHEMBL1604692 Potency 50.1 nM
CC12C=C(/C=C/CCc3ccco3)C(C)(C1)C(CCc1ccco1)CC2=O CHEMBL1314768 Potency 50.1 nM
Cc1cc(C)c2c(=O)n(CC(=O)NCCCN3CCN(c4ccccc4F)CC3)sc2n1 CHEMBL1302139 Potency 50.1 nM
O=c1c2ccccc2nc(SCc2ccccc2)n1Cc1ccco1 CHEMBL1361777 Potency 50.1 nM
Cc1cc(C)n2c(S)nnc2n1 CHEMBL1531298 Potency 50.1 nM
COc1cccc(-c2cc(C(F)(F)F)nc(N3CCCCC3)n2)c1 CHEMBL1425091 Potency 50.1 nM
CCN([C@@H]1CCN(C(C)c2ccc(F)cc2)C1)S(=O)(=O)NCCc1c(-c2cccs2)n[nH]c1-c1cnccn1 CHEMBL1796851 IC50 51.0 nM
O=C(Nc1ccc(Cl)cc1Cl)c1cn[nH]n1 CHEMBL3604174 IC50 56.0 nM
O=C(OCC#CCSc1nnc(-c2ccccc2Cl)o1)c1ccc(F)cc1 CHEMBL1270607 Ki(app) 57.0 nM
N#Cc1ccccc1OCC(=O)OCC(=O)c1ccc2c(c1)NC(=O)CO2 CHEMBL1411000 Potency 63.1 nM
Cc1ccc(S(=O)(=O)N2CCN(C(=O)COC(=O)c3cc(C)oc3C)CC2)cc1 CHEMBL1342133 Potency 63.1 nM
Oc1c(C(c2ccccn2)N2CCOCC2)ccc2cccnc12 CHEMBL1530097 Potency 63.1 nM
Cc1cc(=O)c2c(O)c(O)ccc2o1 CHEMBL1568805 Potency 63.1 nM
CCOCCn1c(N2CCN(c3ccc(OC)cc3)CC2)nc2c1c(=O)[nH]c(=O)n2C CHEMBL1445333 Potency 63.1 nM
CC(C)C(c1nnnn1Cc1ccco1)N1CCN(C2CCCC2)CC1 CHEMBL1428942 Potency 63.1 nM
O=c1c2ccccc2[se]n1-c1ccccc1 CHEMBL51085 Potency 63.1 nM
O=C(Nc1ccc(NC(=O)c2ccco2)nc1)c1cccnc1 CHEMBL1542791 Potency 63.1 nM
Cc1cccc(C)c1NC(=O)N1CC=C(n2c(O)nc3ccccc32)CC1 CHEMBL1336392 Potency 63.1 nM
CCN(CC)C(=S)SSC(=S)N(CC)CC CHEMBL964 Potency 63.1 nM
C[C@H](Cc1cc(O)c(O)cc1Cl)[C@@H](C)Cc1cc(O)c(O)cc1Cl CHEMBL314941 IC50 65.0 nM
O=C(Nc1ccc(F)cc1Cl)c1cn[nH]n1 CHEMBL3604173 IC50 68.0 nM
Nc1c[nH]nc1C(=O)Nc1ccc(F)cc1Cl CHEMBL3604166 IC50 69.0 nM
CCN([C@@H]1CCN(C(C)c2ccc(F)cc2)C1)S(=O)(=O)NCCc1nc(-c2cccs2)[nH]c1-c1ccc(OC)cc1 CHEMBL235920 Ki 73.0 nM
O=C(OCC#CCSc1nnc(-c2cccc3ccccc23)o1)c1cccc2[nH]ccc12 CHEMBL1270809 Ki(app) 76.0 nM
O=C(Nc1cc(Cl)ccc1Cl)c1cn[nH]n1 CHEMBL3604175 IC50 79.0 nM
CC1=C(Br)C(=O)C(C)=C(Br)C1=O CHEMBL1566105 Potency 79.4 nM
CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)O CHEMBL15594 Potency 79.4 nM
COc1ccc2[nH]c3c(c2c1)CCNC3 CHEMBL266084 Potency 79.4 nM
COc1ccc2[nH]c3c(=O)n(CCCCC(=O)N4CCCC4)c(=S)[nH]c3c2c1 CHEMBL1978817 Potency 79.4 nM
CCCCCCCCCC(=O)c1c(C(=O)OCC)[nH]c2cc(Cl)ccc12 CHEMBL3622738 Ki 80.0 nM
COc1ccccc1-c1nnc(SCC#CCOC(=O)c2ccc(F)cc2)o1 CHEMBL1270811 Ki(app) 81.0 nM
O=C(OCC#CCSc1nnc(-c2cccs2)o1)c1ccc(F)cc1 CHEMBL1270707 Ki(app) 82.0 nM
C[C@H](Cc1cc(O)c(O)cc1Br)[C@@H](C)Cc1cc(O)c(O)cc1Br CHEMBL89283 IC50 83.0 nM
C[C@H](Cc1ccc(O)c(O)c1)[C@@H](C)Cc1ccc2c(c1)OC(C)(C)O2 CHEMBL88952 IC50 85.0 nM
O=C(OCC#CCSc1nnc(-c2cccc3ccccc23)o1)C1CCC1 CHEMBL1270504 Ki(app) 85.0 nM
CCCCCCNC(=O)n1nc(C(=O)Nc2ccc(F)cc2Cl)cc1C CHEMBL3597775 IC50 85.0 nM
O=C(Nc1cnc2ccccc2c1)c1cc[nH]n1 CHEMBL3604141 IC50 92.0 nM
O=C(Nc1ccc(F)cc1C(F)(F)F)c1cc[nH]n1 CHEMBL3604134 IC50 94.0 nM
O=C(Nc1ccccc1)c1cn[nH]n1 CHEMBL3604170 IC50 97.0 nM
O=C(OCC#CCSc1nnc(-c2cccc3ccccc23)o1)c1ccc(Cl)c(C(F)(F)F)c1 CHEMBL1270313 Ki(app) 100.0 nM
Cc1ccc2nc3c(cc(C(=O)NCc4ccccc4)c(=N)n3CCCn3ccnc3)c(=O)n2c1 CHEMBL531269 Potency 100.0 nM
CC1(C)c2ccccc2N2CC(=O)NC21/C=C/c1ccco1 CHEMBL1324015 Potency 100.0 nM
CC(Cc1ccc(O)c(O)c1)C(C)Cc1ccc(O)c(O)c1 CHEMBL52 Potency 100.0 nM
O=[N+]([O-])c1ccc(-c2nc(-c3ccc(F)cc3)c(-c3ccncc3)[nH]2)cc1 CHEMBL17331 Potency 100.0 nM
Cc1nn(CC(=O)Nc2ccc3c(c2)oc2ccccc23)c(=O)c2ccccc12 CHEMBL1577137 Potency 100.0 nM
CO[C@@H](C(C)C)[C@@H](C)[C@@H]1OC(=O)C[C@@H]1O CHEMBL1599753 Potency 100.0 nM
CCOc1ccc(NC(=O)CN2CCN(CC(=O)c3ccc(OC)c(OC)c3)CC2)cc1 CHEMBL1479845 Potency 100.0 nM
Cc1ccc(C2=C(Cl)C(=O)C(c3ccc(C)cc3)=C(Cl)C2=O)cc1 CHEMBL1556742 Potency 100.0 nM
O=C(CCN1c2ccccc2Sc2ccccc21)OCc1nnc(-c2ccccc2)o1 CHEMBL1501188 Potency 100.0 nM
c1ccc2[nH]c(SN3CCOCC3)nc2c1 CHEMBL1490628 Potency 100.0 nM
C[N+]1(C)CCc2cc(O)c(O)cc2[C@H]1Cc1ccc(O)c(O)c1 CHEMBL1358885 Potency 100.0 nM
CC(C)c1ccccc1N1CC(C(=O)O)CC1=O CHEMBL1501963 Potency 100.0 nM
O=C(NCCOc1ccccc1)C1CCCN1C(=O)c1cccs1 CHEMBL1468412 Potency 100.0 nM
O=c1c2ccccc2sn1-c1ccc(S(=O)(=O)N2CCCCC2)cc1 CHEMBL1530439 Potency 100.0 nM
COc1ccc(-c2cc(C(F)(F)F)nc(NCc3ccco3)n2)cc1OC CHEMBL1559347 Potency 100.0 nM
COC(=O)[C@@H]1CC[C@H](C)[C@@H](c2ccc(C)cc2)N1C(=O)c1ccc(/C=N\O[C@@H](C)c2cc(-c3c(C)cc(C)cc3C)no2)cc1 CHEMBL1358566 Potency 100.0 nM
N=C1Sc2ccccc2C2=NCCCN12 CHEMBL595227 Potency 100.0 nM
NS(=O)(=O)c1cc2c(cc1Cl)N[C@@H]([C@@H]1C[C@@H]3C=C[C@H]1C3)NS2(=O)=O CHEMBL1333981 Potency 100.0 nM
Cc1nc2ncnn2c(N2CCN(C(c3ccccc3)c3ccccc3)CC2)c1C CHEMBL1431620 Potency 100.0 nM
O=c1c2ccccc2sn1-c1ccc(S(=O)(=O)N2CCCC2)cc1 CHEMBL1392315 Potency 100.0 nM
COc1ccc(OC)c(CCNC(=O)Cn2sc3nc(C)cc(C)c3c2=O)c1 CHEMBL1510394 Potency 100.0 nM
CCCNc1oc(-c2cccc3ccccc23)nc1C#N CHEMBL1498973 IC50 100.0 nM
CNc1oc(-c2cccc3ccccc23)nc1C#N CHEMBL1548353 Ki 100.0 nM
CCCCCCCC(=O)c1c(C(=O)OCC)[nH]c2cc(Cl)ccc12 CHEMBL3622739 Ki 100.0 nM
CC(Cc1ccc(O)c(O)c1)[C@H](C)Cc1ccc(O)c(O)c1 CHEMBL185893 IC50 110.0 nM
O=C(Nc1ccc(F)cc1Cl)c1cc(C(F)(F)F)[nH]n1 CHEMBL3604160 IC50 112.0 nM
O=C(Nc1ccc(F)cc1Cl)c1n[nH]cc1C(F)(F)F CHEMBL3604159 IC50 117.0 nM
O=C(Nc1ccc(F)cn1)c1cc[nH]n1 CHEMBL3604137 IC50 118.0 nM
CCNc1oc(-c2cccc3ccccc23)nc1C#N CHEMBL1571456 IC50 120.0 nM
CCCCNc1oc(-c2cccc3ccccc23)nc1C#N CHEMBL3262919 IC50 120.0 nM
CCOC(=O)c1[nH]c2cc(Cl)ccc2c1C(=O)C[C@H](C)CCCC(C)C CHEMBL3622736 Ki 120.0 nM
Clc1ccc2oc(-c3cc[nH]n3)nc2c1 CHEMBL3604181 IC50 124.0 nM
CC1CCN(c2oc(-c3ccccc3F)nc2C#N)CC1 CHEMBL1339679 Potency 125.9 nM
CN(C)C(=S)SSC(=S)N(C)C CHEMBL120563 Potency 125.9 nM
COc1ccc(OC)c(Nc2nc(-c3ccc(O)c(O)c3)cs2)c1 CHEMBL1419335 Potency 125.9 nM
Cc1cc2occ(CC(=O)O)c2cc1C CHEMBL1336671 Potency 125.9 nM
COc1cccc(C(=O)Nc2cccc(-c3nnc(-c4ccccc4)o3)c2)c1 CHEMBL1416666 Potency 125.9 nM
CC(C)(OO)c1ccccc1 CHEMBL1518369 Potency 125.9 nM
COc1ccc(CN(C(=O)c2ccco2)c2ccc(C)cc2)cc1OC CHEMBL1465860 Potency 125.9 nM
CC(C(=O)N1CCOCC1)N1c2cccc3cccc(c23)S1(=O)=O CHEMBL1406638 Potency 125.9 nM
O=C1CCCC=C1[C@@H](O)CCOC(c1ccccc1)(c1ccccc1)c1ccccc1 CHEMBL1598228 Potency 125.9 nM
CSc1nc2ccc(Nc3nc(N4CCOCC4)nc(N4CCOCC4)n3)cc2s1 CHEMBL1509321 Potency 125.9 nM
CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O CHEMBL8739 Potency 125.9 nM
O=C(O)[C@H]1CN(CCCP(=O)(O)O)CCN1 CHEMBL47277 Potency 125.9 nM
CCCCCNC(=O)n1ccc(C(=O)Nc2ccc(F)cc2Cl)n1 CHEMBL3597765 IC50 130.0 nM
O=C(Nc1ncc(Cl)s1)c1cc[nH]n1 CHEMBL3604139 IC50 130.0 nM
O=C(/C=C/c1ccc(O)c(O)c1)OCCc1ccccc1 CHEMBL319244 IC50 130.0 nM
O=C(OCC#CCSc1nnc(-c2cccc3ncccc23)o1)c1ccc(F)cc1 CHEMBL1270915 Ki(app) 140.0 nM
CCOC(=O)c1[nH]c2cc(Cl)ccc2c1/C=N/NC(=O)CSc1nc2ccccc2[nH]1 CHEMBL4521335 IC50 140.0 nM
CCOC(=O)CCCCCNC(=O)n1ccc(C(=O)Nc2ccc(F)cc2Cl)n1 CHEMBL3597766 IC50 141.0 nM
COc1ccc(C2COc3cc(O)c(O)cc3C2)cc1 CHEMBL239247 IC50 150.0 nM
Oc1ccc(O)c2c(O)cccc12 CHEMBL1331245 Potency 158.5 nM
CCOC(=O)N1CCN(C(=O)CN(C2CCCCC2)S(=O)(=O)c2ccc(C)cc2)CC1 CHEMBL1416105 Potency 158.5 nM
Cc1sc2nc(C3CC3)nc(N3CCN(S(=O)(=O)c4ccc(F)cc4)CC3)c2c1C CHEMBL1313601 Potency 158.5 nM
C=C(CC(=O)O)C(=O)O CHEMBL1565425 Potency 158.5 nM
CCn1c2ccccc2c2nnc(SCN3C(=O)c4ccccc4C3=O)nc21 CHEMBL1599589 Potency 158.5 nM
O=C(Nc1ccc(Cl)cc1C(=O)Nc1ccccn1)c1ccco1 CHEMBL1421221 Potency 158.5 nM
CC(C)(C)C1=Nn2c(nnc2-c2[nH]nc3c2CCC3)SC1 CHEMBL1495812 Potency 158.5 nM
N#Cc1ccc(COc2ccc(CCO)cc2-n2nc3ccccc3n2)cc1 CHEMBL1308536 Potency 158.5 nM
Cc1ccnc(SCC(=O)O)n1 CHEMBL1339207 Potency 158.5 nM
O=C(O)CN1C(=O)c2cccc3cccc(c23)C1=O CHEMBL63055 Potency 158.5 nM
C=CC[C@@H]1C=C[C@H](O/N=C(\C)CCN2CCc3nc(CC)c(CC)cc3C2)[C@H](CO)O1 CHEMBL1355703 Potency 158.5 nM
COCCn1c(C)cc(C(=O)COC(=O)c2ccc3ncsc3c2)c1C CHEMBL1328025 Potency 158.5 nM
CCCCC/C=C\C/C=C\CCCCCCCC(=O)O CHEMBL267476 Potency 158.5 nM
O=C1C(Cl)=C(Cl)C(=O)C(Cl)=C1Cl CHEMBL192627 Potency 158.5 nM
CCc1cc(O)c(O)cc1C[C@@H](C)[C@@H](C)Cc1cc(O)c(O)cc1CC CHEMBL92212 IC50 160.0 nM
O=C(OCC#CCSc1nnc(-c2cccc3ccccc23)o1)c1ccco1 CHEMBL1270410 Ki(app) 170.0 nM
CCCCCCCCCCCC(=O)c1c(C(=O)OCC)[nH]c2cc(Cl)ccc12 CHEMBL3622737 Ki 170.0 nM
O=C(Nc1ccc(Cl)c(Cl)c1)c1cc[nH]n1 CHEMBL3604131 IC50 180.0 nM
Cc1c[nH]nc1C(=O)Nc1ccc(F)cc1Cl CHEMBL3604146 IC50 183.0 nM
O=C(Nc1ccc(F)cc1Cl)c1n[nH]cc1I CHEMBL3604157 IC50 184.0 nM
CCOC(=O)c1[nH]c2cc(Cl)ccc2c1/C=C/C(=O)NCCc1ccc(Cl)cc1Cl CHEMBL4580232 IC50 190.0 nM
CCOC(=O)c1[nH]c2cc(Cl)ccc2c1/C=C/C(=O)NCc1ccccc1OC CHEMBL4560124 IC50 190.0 nM
Oc1ccc2ccccc2c1/C=C\c1ccc2c(Br)cc(Br)c(O)c2n1 CHEMBL1317013 Potency 199.5 nM
CC1CCCC(C)N1C(=O)CSc1nnc(NC(=O)Cc2cccs2)s1 CHEMBL1578549 Potency 199.5 nM
COc1cc2c(cc1OC)CN(Cc1cccs1)CC2 CHEMBL1570042 Potency 199.5 nM
CCOC(=O)Cc1csc(SCC(=O)Nc2cccc(C#N)c2)n1 CHEMBL1461922 Potency 199.5 nM
Cc1ccc2nc(O)c(CN(Cc3ccc4c(c3)OCO4)Cc3nnnn3C3CCCC3)cc2c1 CHEMBL1461818 Potency 199.5 nM
CCOC(=O)Cc1csc(-n2sc3ccccc3c2=O)n1 CHEMBL1412731 Potency 199.5 nM
Cc1ccc(C)c(C(=O)COC(=O)c2ccc(Br)o2)c1 CHEMBL1580240 Potency 199.5 nM
O=C(Oc1cccc2cccnc12)c1cccs1 CHEMBL1445768 Potency 199.5 nM
CCn1c(CCNC(=O)c2cccs2)nnc1SCC(=O)c1ccc(OC)cc1 CHEMBL1367224 Potency 199.5 nM
Cc1ccc2c(c1)c(C)c(C)n2CC(O)Cn1nnc2ccccc21 CHEMBL1323007 Potency 199.5 nM
[O-][n+]1ccccc1[S-] CHEMBL1200471 Potency 199.5 nM
Oc1c2c(nc3c(-c4ccccc4)cnn13)CCCC2 CHEMBL1521090 Potency 199.5 nM
COc1ccc(NC(=O)CSc2nnc(CNc3ccc(F)cc3)o2)c(OC)c1 CHEMBL1470527 Potency 199.5 nM
O=C(c1ccncc1)N1CCC2(CCCN(Cc3nccs3)C2)CC1 CHEMBL1591908 Potency 199.5 nM
CC(C)CC(=O)Oc1ccc(C[C@@H](C)[C@@H](C)Cc2ccc(OC(=O)CC(C)C)c(OC(=O)CC(C)C)c2)cc1OC(=O)CC(C)C CHEMBL315582 AC50 200.0 nM
CCCCCC(=O)Oc1ccc(C[C@@H](C)[C@@H](C)Cc2ccc(OC(=O)CCCCC)c(OC(=O)CCCCC)c2)cc1OC(=O)CCCCC CHEMBL316389 AC50 200.0 nM
Cc1cccc(C2COc3cc(O)c(O)cc3C2)c1 CHEMBL239893 IC50 210.0 nM
Cc1cccc(C2COc3cc(O)c(O)cc3C2=O)c1 CHEMBL239033 IC50 210.0 nM
CCCCCC(=O)c1c(C(=O)OCC)[nH]c2cc(Cl)ccc12 CHEMBL3622740 Ki 210.0 nM
O=C(Nc1ccc(F)cc1Cl)c1cc(C(F)F)[nH]n1 CHEMBL3604163 IC50 216.0 nM
CCOC(=O)c1[nH]c2cc(Cl)ccc2c1C(=O)CCc1ccccc1 CHEMBL3622745 Ki 220.0 nM
CCCCCCNC(=O)n1cc(C)c(C(=O)Nc2cccc3c2OC(F)(F)O3)n1 CHEMBL3597773 IC50 222.0 nM
CCOC(=O)c1[nH]c2cc(Cl)ccc2c1/C=N/NC(=O)COc1ccccc1Cl CHEMBL4451326 IC50 230.0 nM
COc1cc(C[C@@H](C)[C@@H](C)Cc2ccc(O)c(O)c2)ccc1O CHEMBL316139 IC50 250.0 nM
CCOC(=O)c1[nH]c2cc(Cl)ccc2c1C(=O)Cc1ccccc1 CHEMBL3622741 Ki 250.0 nM
O=C(COC(=O)CCC(=O)c1cccs1)NCc1ccco1 CHEMBL1458486 Potency 251.2 nM
Cc1ccc2c(c1)c(C)c(C)n2CC(O)Cn1nc(C)cc1C CHEMBL1477693 Potency 251.2 nM
CC(=O)c1cccc(NC(=O)NC2CCCCC2)c1 CHEMBL1454917 Potency 251.2 nM
c1ccc(-c2cnc(-c3ccc(-c4ncc(-c5ccccc5)o4)cc3)o2)cc1 CHEMBL1533636 Potency 251.2 nM
O=C1c2ccc(O)c(O)c2C(=O)c2c(O)ccc(O)c21 CHEMBL29898 Potency 251.2 nM
O=C1C=CC2=C3c4cc(O)c(O)cc4CC3(O)COC2=C1O CHEMBL1730100 Potency 251.2 nM
Cc1cc2c(c(=O)o1)[C@H](O)[C@H]1O[C@@H]1C2=O CHEMBL1592542 Potency 251.2 nM
N#C/C(=C\c1c[nH]c2ccccc12)C(=O)c1ccc(O)c(O)c1 CHEMBL68534 Potency 251.2 nM
CCOC(=O)N1CCN(c2nc(-c3ccco3)cc(C(F)(F)F)n2)CC1 CHEMBL1342791 Potency 251.2 nM
CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)Nc1ccc(O)cc1 CHEMBL39878 Potency 251.2 nM
C[C@H](NC(=O)/C(C#N)=C/c1ccc(O)c(O)c1)c1ccccc1 CHEMBL261557 Potency 251.2 nM
CC(=O)N(CC1CCCO1)c1nnc(-c2ccccn2)s1 CHEMBL1389196 Potency 251.2 nM
Oc1ccc([C@@H]2CNCc3sccc32)cc1O CHEMBL407489 Potency 251.2 nM
Nc1nonc1-n1nnc(C(=O)c2ccccc2)c1-c1ccccc1 CHEMBL1391481 Potency 251.2 nM
O=C(OCC#CCSc1nnc(-c2cccc3ccccc23)o1)C1CC1 CHEMBL1270411 Ki(app) 270.0 nM
O=C(Nc1ccc(F)cc1)c1cc[nH]n1 CHEMBL3604130 IC50 270.0 nM
CCOC(=O)c1[nH]c2cc(Cl)ccc2c1/C=C/C(=O)NCCc1ccccc1OC CHEMBL4574657 IC50 270.0 nM
O=C(Nc1ccc(F)cc1Cl)c1n[nH]c(C(F)(F)F)c1C(F)(F)F CHEMBL3604161 IC50 279.0 nM
CCCC(=O)c1c(C(=O)OCC)[nH]c2cc(Cl)ccc12 CHEMBL3622734 Ki 290.0 nM
CC(=O)n1ccc(C(=O)Nc2ccc(Cl)c(Cl)c2)n1 CHEMBL3597762 IC50 292.0 nM
O=C(Nc1ccc(CCc2ccc(O)c(O)c2)cc1)c1ccccc1O CHEMBL367410 IC50 300.0 nM
O=C(Nc1ccc(CCCCc2ccc(O)c(O)c2)cc1)c1ccccc1O CHEMBL177100 IC50 300.0 nM
O=C(Nc1ccc(CCCc2ccc(O)c(O)c2)cc1)c1ccccc1O CHEMBL176689 IC50 300.0 nM
CCCC(=O)Oc1ccc(C[C@@H](C)[C@@H](C)Cc2ccc(OC(=O)CCC)c(OC(=O)CCC)c2)cc1OC(=O)CCC CHEMBL313630 AC50 300.0 nM
CCC(=O)Oc1ccc(C[C@@H](C)[C@@H](C)Cc2ccc(OC(=O)CC)c(OC(=O)CC)c2)cc1OC(=O)CC CHEMBL329336 AC50 300.0 nM
CC1=C(CC/C(C)=C/CC/C(C)=C/Cc2cc(O)ccc2O)C(C)(C)CCC1 CHEMBL425166 IC50 300.0 nM
CCCCCNc1oc(-c2cccc3ccccc23)nc1C#N CHEMBL3262920 IC50 300.0 nM
CCOC(=O)c1[nH]c2cc(Cl)ccc2c1C(=O)Cc1ccc(F)cc1 CHEMBL3622744 Ki 310.0 nM
O=c1c(-c2ccccc2)nc2cnc(N3CCNCC3)nc2n1-c1ccccc1 CHEMBL1473149 Potency 316.2 nM
COc1ccc(-c2cn3cc(C)ccc3n2)cc1OC CHEMBL1471326 Potency 316.2 nM
Cc1cc(N2CCOCC2)nc2cc(O)ccc12 CHEMBL1313467 Potency 316.2 nM
O=C(Nc1cccc(F)c1)N1CCCC2(CCN(C(=O)c3ccco3)CC2)C1 CHEMBL1603627 Potency 316.2 nM
CCCN1CCc2cccc3c2[C@@H]1Cc1ccc(O)c(O)c1-3 CHEMBL330274 Potency 316.2 nM
CCN1CCN(Cc2c(C)nc3ccc(OC)cc3c2O)CC1 CHEMBL1416595 Potency 316.2 nM
CCNC(=O)[C@@H]1O[C@@H](n2cnc3c(N)nc(NCCc4ccc(CCC(=O)O)cc4)nc32)[C@H](O)[C@@H]1O CHEMBL1490326 Potency 316.2 nM
O=C(Nc1ccc2c(c1)Cc1ccccc1-2)[C@@H]1[C@H](C(=O)O)[C@]2(Cl)C(Cl)=C(Cl)[C@@]1(Cl)C2(Cl)Cl CHEMBL1596186 Potency 316.2 nM
O=C1C(Cl)=C(Nc2ccc(S(=O)(=O)Nc3ccccn3)cc2)C(=O)c2ccccc21 CHEMBL1214274 Potency 316.2 nM
CC1(C)OCC(CSC2=C(SCC3COC(C)(C)O3)C(=O)c3ncccc3C2=O)O1 CHEMBL1596675 Potency 316.2 nM
COc1ccc(C2CC(=O)N3CN(c4ccccc4F)CSC3=C2C#N)cc1OC CHEMBL1579564 Potency 316.2 nM
O=C(Oc1ccccc1)N1CCC2(CCCN(c3ccncc3)C2)CC1 CHEMBL1473754 Potency 316.2 nM
CN(C)c1ccc(-c2nnc(-c3ccc(S(=O)(=O)C(F)F)cc3)o2)cc1 CHEMBL1304349 Potency 316.2 nM
CC(=O)C1=C(C)NC(SCSc2ccccc2)=C(C#N)C1c1cccnc1 CHEMBL1532337 Potency 316.2 nM
CC[C@]1(O)C[C@H]2CN(CCc3c([nH]c4ccccc34)[C@](C(=O)OC)(c3cc4c(cc3OC)N(C=O)[C@H]3[C@@](O)(C(=O)OC)[C@H](OC(C)=O)[C@@]5(CC)C=CCN6CC[C@]43[C@H]65)C2)C1 CHEMBL1363013 Potency 316.2 nM
C=CCn1c(SCc2cc(=O)n3ccsc3n2)nnc1C1CCCCC1 CHEMBL1375487 Potency 316.2 nM
CCN(CC)CC[n+]1ccc2c(C)c3[nH]c4ccc(O)cc4c3c(C)c2c1 CHEMBL1790009 Potency 316.2 nM
Oc1nc2c(c3c1CCCC3)CCCC2 CHEMBL1376108 Potency 316.2 nM
COC(=O)Oc1nsnc1N1CCOCC1 CHEMBL1581518 Potency 316.2 nM
O=C(Nc1ccc2ccccc2n1)c1cc[nH]n1 CHEMBL3604140 IC50 334.0 nM
Nc1cc(C(=O)Nc2ccc(F)cc2Cl)n[nH]1 CHEMBL3604167 IC50 334.0 nM
C[C@H](Cc1cc(O)c(O)cc1[N+](=O)[O-])[C@@H](C)Cc1cc(O)c(O)cc1[N+](=O)[O-] CHEMBL92359 IC50 350.0 nM
Oc1cc2c(cc1O)OCC(c1ccc3c(c1)OCO3)C2 CHEMBL239677 IC50 350.0 nM
Cc1cc(C(=O)Nc2ccc(F)cc2Cl)n[nH]1 CHEMBL3604147 IC50 376.0 nM
CC(=O)c1cc(O)c(O)cc1C[C@@H](C)[C@@H](C)Cc1cc(O)c(O)cc1C(C)=O CHEMBL89275 IC50 380.0 nM
O=C(Nc1ccccc1Cl)c1cn[nH]n1 CHEMBL3604172 IC50 392.0 nM
COc1ccc(S(=O)(=O)N2CCC(C(=O)Nc3nnc(CCN4CCCCC4)s3)CC2)cc1 CHEMBL1318914 Potency 398.1 nM
CCS(=O)(=O)NCc1ccc2[nH]c3c(c2c1)CCCC3 CHEMBL1576128 Potency 398.1 nM
CN[C@@H](C)[C@@H](O)c1ccccc1 CHEMBL1590 Potency 398.1 nM
c1ccc2[nH]c(NC3=NCCC3)nc2c1 CHEMBL1610991 Potency 398.1 nM
Cc1cc(-c2ccc(/N=N/c3cc(S(=O)(=O)[O-])c4ccccc4c3N)c(C)c2)ccc1/N=N/c1cc(S(=O)(=O)[O-])c2ccccc2c1N CHEMBL1471289 Potency 398.1 nM
O=c1cc(-c2ccc(O)c(O)c2)oc2cccc(O)c12 CHEMBL243677 Potency 398.1 nM
Cc1ccc(-c2csc(N(CC3CCCO3)C(=O)c3ccco3)n2)cc1 CHEMBL1404076 Potency 398.1 nM
CN(C)[C@@H]1C(O)=C(C(N)=O)C(=O)[C@@]2(O)C(O)=C3C(=O)c4c(O)cccc4[C@@](C)(O)[C@H]3[C@H](O)[C@@H]12 CHEMBL1607480 Potency 398.1 nM
O=S(=O)(c1cc(Cl)ccc1Cl)N1CCCCC1 CHEMBL1583499 Potency 398.1 nM
CCN(CC)S(=O)(=O)c1ccc(NC(=O)COC(=O)c2ccc(Br)o2)cc1 CHEMBL1372528 Potency 398.1 nM
O=C(Cc1ccccc1)N1CCC(c2nc(-c3ccc(F)cc3)no2)CC1 CHEMBL1302376 Potency 398.1 nM
CCC(c1nnnn1C1CCCC1)N1CCN(c2ccccc2)CC1 CHEMBL1369878 Potency 398.1 nM
CC(C)(C)CC(C)(C)c1cc(O)c(O)c(CN2CCCCC2)c1 CHEMBL1325511 Potency 398.1 nM
Cc1cc(C)nc(/N=c2/ssnc2Cl)c1 CHEMBL1968355 Potency 398.1 nM
CN(C)Cc1cc(O)c(O)c(CN(C)C)c1 CHEMBL1535057 Potency 398.1 nM
N#C/C(=C\c1ccc(O)c(O)c1)C(=O)OCCc1cccs1 CHEMBL37081 Potency 398.1 nM
O=C(NC1CCCC1)C(c1ccsc1)N(Cc1ccco1)C(=O)Cc1cccs1 CHEMBL1484731 Potency 398.1 nM
Cc1noc(C)c1COC(=O)CN(C)S(=O)(=O)c1ccc(Cl)cc1 CHEMBL1548412 Potency 398.1 nM
CCOc1ccc(Nc2cc(C)nc(-n3nc(C)cc3C)n2)cc1 CHEMBL600060 Potency 398.1 nM
CC(C)CN1CCCC2(CCN(C(=O)Oc3ccccc3)CC2)C1 CHEMBL1363568 Potency 398.1 nM
O=C(Nc1ccc(CCc2ccc(O)c(O)c2)cc1)c1ccc(Cl)cc1O CHEMBL177598 IC50 400.0 nM
Cc1ccc(C(=O)Nc2ccc(CCc3ccc(O)c(O)c3)cc2)c(O)c1 CHEMBL175216 IC50 400.0 nM
O=C(Nc1ccc(CCc2ccc(O)c(O)c2)cc1)c1ccc2ccccc2c1O CHEMBL413350 IC50 400.0 nM
CC(c1cc2ccccc2s1)N(O)C(N)=O CHEMBL93 IC50 400.0 nM
CCOC(=O)c1[nH]c2cc(Cl)ccc2c1/C=C/C(=O)NCc1cccc(OC)c1 CHEMBL4547876 IC50 400.0 nM
O=C(Nc1cc2ccccc2cn1)c1cc[nH]n1 CHEMBL3604143 IC50 406.0 nM
O=C1CCN(c2ccccc2)N1 CHEMBL7660 IC50 420.0 nM
O=C(Nc1ccc(C(F)(F)F)cc1)c1cc[nH]n1 CHEMBL3604133 IC50 448.0 nM
CNc1oc(-c2cccc(Cl)c2Cl)nc1C#N CHEMBL3262908 IC50 460.0 nM
COc1ccccc1C(=O)OCC#CCSc1nnc(-c2cccc3ccccc23)o1 CHEMBL1271430 Ki(app) 470.0 nM
CCOC(=O)c1[nH]c2cc(Cl)ccc2c1/C=N/NC(=O)C1CCN(C(=O)OC(C)(C)C)CC1 CHEMBL4473320 IC50 470.0 nM
CCOC(=O)c1[nH]c2cc(Cl)ccc2c1C(=O)Cc1ccc(Cl)cc1 CHEMBL3622743 Ki 480.0 nM
CC(C)C(=O)Oc1ccc(C[C@@H](C)[C@@H](C)Cc2ccc(OC(=O)C(C)C)c(OC(=O)C(C)C)c2)cc1OC(=O)C(C)C CHEMBL313613 AC50 500.0 nM
CC1=CC[C@H]2C(C)(C)CCC[C@]2(C)[C@H]1C[C@@H](O)[C@H](C)CCC/C(C)=C/Cc1cc(O)ccc1O CHEMBL230058 IC50 500.0 nM
Fc1ccc(-c2nc3n(c2-c2ccncc2)CCS3)cc1 CHEMBL1594610 Potency 501.2 nM
O=P(Nc1nccs1)(c1ccccc1)c1nc2ccccc2s1 CHEMBL1410147 Potency 501.2 nM
CCOC(=O)CCN1C(=O)[C@H]2[C@H]3[C@H](O)[C@H](O)C/C(=N/NC(=O)OCC)[C@@H]3CC[C@@H]2C1=O CHEMBL1314644 Potency 501.2 nM
Cn1c(C(=O)NCCCN2CCOCC2)cc2c(=O)n(C)c3ccccc3c21 CHEMBL1472229 Potency 501.2 nM
CN1C=CC2=C(C#N)C(N)C(C#N)(C#N)C(c3ccccc3)C2C1 CHEMBL1420573 Potency 501.2 nM
C[C@@H]1O[C@@H](O[C@@H]2[C@@H](O)[C@H](OCCc3ccc(O)c(O)c3)O[C@H](CO[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)[C@H]2OC(=O)/C=C/c2ccc(O)c(O)c2)[C@H](O)[C@H](O)[C@H]1O CHEMBL510539 Potency 501.2 nM
CCOCCN(C=O)c1cccc(OC)c1 CHEMBL1314146 Potency 501.2 nM
O=c1cc(-c2cccc(O)c2O)oc2ccccc12 CHEMBL242171 Potency 501.2 nM
CS(=O)(=O)N1CCC2(CCCN(C(=O)Nc3cccc(F)c3)C2)CC1 CHEMBL1450993 Potency 501.2 nM
CCn1c(CCCc2nc3c(=O)n(C)c(=O)n(C)c3[nH]2)nc2c1c(=O)n(C)c(=O)n2C CHEMBL1491633 Potency 501.2 nM
C[C@@H]1CC[C@H]2C(=O)N3[C@@H](CC[C@@H](C)[C@@H]3c3ccc(Br)cc3)C(=O)N2[C@@H]1c1ccc(Br)cc1 CHEMBL1519490 Potency 501.2 nM
O=C(COC(=O)c1ccc(=O)n(Cc2ccccc2)n1)Nc1ccc2c(c1)OCCO2 CHEMBL1383927 Potency 501.2 nM
CCN1CCN(Cc2ccc(NC(=O)Nc3cccs3)cc2)CC1 CHEMBL1402138 Potency 501.2 nM
COC(=O)C/C=C\[C@@H](C)[C@@H](/C=N\O[C@@H](C)c1cn([C@H](CO)Cc2ccccc2)nn1)OC CHEMBL1322319 Potency 501.2 nM
COC(=O)[C@H]1[C@@H](c2ccccc2)[C@@]2(c3ccccc3)Oc3ccccc3[C@@]1(O)[C@@H]2O CHEMBL1397443 Potency 501.2 nM
CS(=O)(=O)N1CCC2(CC1)CN(C(=O)Nc1ccccc1)C2 CHEMBL1414946 Potency 501.2 nM
Cc1ccc(-n2sc3ccccc3c2=O)cc1S(=O)(=O)N1CCCCC1 CHEMBL1423690 Potency 501.2 nM
CS(=O)(=O)N1CCC2(CCCN(c3ncccn3)C2)CC1 CHEMBL1317579 Potency 501.2 nM
CC(C)(C)NCc1cccn1-c1sc2c(c1C#N)CCCC2 CHEMBL1311973 Potency 501.2 nM
O=C1Oc2ccccc2C(=O)/C1=C/Nc1nc(-c2ccc(O)c(O)c2)cs1 CHEMBL1514547 Potency 501.2 nM
C=CCNc1oc(-c2cccc3ccccc23)nc1C#N CHEMBL1588672 Potency 501.2 nM
Oc1ccc(C2COc3cc(O)c(O)cc3C2)cc1 CHEMBL8328 IC50 510.0 nM
CNc1sc(-c2cccc3ccccc23)nc1C#N CHEMBL3262925 IC50 550.0 nM
COc1ccc(C[C@@H](C)[C@@H](C)Cc2ccc(O)c(O)c2)cc1OC CHEMBL91531 IC50 580.0 nM
COc1ccc(C[C@@H](C)[C@@H](C)Cc2ccc(OC)c(O)c2)cc1O CHEMBL103600 IC50 580.0 nM
O=C(Nc1cnc2cc(F)ccc2c1)c1cn[nH]n1 CHEMBL3604178 IC50 596.0 nM
O=C(Nc1ccc(CCc2ccc(O)c(O)c2)cc1)c1c(O)ccc2ccccc12 CHEMBL173368 IC50 600.0 nM
O=C(OCCCCSc1nnc(-c2cccc3ccccc23)o1)c1ccc(F)cc1 CHEMBL1271119 Ki(app) 600.0 nM
O=c1cc(-c2ccccc2)oc2cc(O)c(O)c(O)c12 CHEMBL8260 Ki 600.0 nM
O=C(Nc1ccc(F)cc1Cl)c1n[nH]cc1[N+](=O)[O-] CHEMBL3603844 IC50 616.0 nM
O=C(Nc1ccccc1Cl)c1cc[nH]n1 CHEMBL1587607 IC50 618.0 nM
CO[C@@H]1COC(=O)CCC[C@@H](C)[C@H](OC)COC(=O)[C@H](Cc2ccccc2)NC(=O)C/C=C\[C@H]1C CHEMBL1514398 Potency 631.0 nM
O=C(CN(C1CC1)S(=O)(=O)c1ccc(S(=O)(=O)N2CCCCCC2)cc1)Nc1ccccc1 CHEMBL1408042 Potency 631.0 nM
O=C(Nc1ccccc1)N1CC2(CCN(S(=O)(=O)c3ccccc3)CC2)C1 CHEMBL1329551 Potency 631.0 nM
CCc1ccc(C2C(C#N)=C(N)SC(N)=C2C#N)cc1 CHEMBL1517350 Potency 631.0 nM
O=C(Nc1cccc2ccccc12)N1CCN(Cc2ccccc2)CC1 CHEMBL1459182 Potency 631.0 nM
COc1cc(C(Nc2ccc3c(c2)OCO3)C(=O)NC2CCCCC2)cc(OC)c1OC CHEMBL1517431 Potency 631.0 nM
COc1cccc(C2C(C(=O)c3cc4ccccc4o3)=C(O)C(=O)N2c2cc(C)on2)c1OC CHEMBL1380975 Potency 631.0 nM
NCCOB(c1ccccc1)c1ccccc1 CHEMBL169233 Potency 631.0 nM
O=C(Nn1cc(C(=O)N2CCN(c3ccccc3F)CC2)c2ccccc2c1=O)c1cnccn1 CHEMBL1486647 Potency 631.0 nM
N#C[C@@H](Cc1ccc(O)c(O)c1)C(=O)N1CCc2ccccc21 CHEMBL1591332 Potency 631.0 nM
CO[C@@H]1/C=C\CC(=O)N[C@@H](C)C(=O)OC[C@@H](OC)[C@H](C)CCCC(=O)OC[C@H]1C CHEMBL1325775 Potency 631.0 nM
COc1ccc(CCNC(=O)c2c(O)c3cccc4c3n(c2=O)CC4)cc1 CHEMBL1440782 Potency 631.0 nM
Oc1c(C(Nc2ccccn2)c2ccccn2)ccc2cccnc12 CHEMBL1330307 Potency 631.0 nM
Cc1cc(N)c2cc(NC(=O)Nc3ccc4nc(C)cc(N)c4c3)ccc2n1 CHEMBL87223 Potency 631.0 nM
COc1cc(NC(=O)c2ccccc2)c(OC)cc1NC(=O)CN1CCOCC1 CHEMBL1546919 Potency 631.0 nM
Nc1nonc1/C(=N/O)N1CCN(CCO)CC1 CHEMBL3189926 Potency 631.0 nM
C[C@H](Cc1ccc(O)c(O)c1)[C@@H](C)Cc1ccc(O)c(O)c1 CHEMBL313972 Potency 631.0 nM
Cc1ccc2cc(C#N)c(N3CCCC3)nc2c1C CHEMBL1528096 Potency 631.0 nM
COC(=O)c1c(NC(=O)Cc2cccs2)sc(C)c1C CHEMBL1524448 Potency 631.0 nM
O=S1(=O)Nc2c(ccc3cccnc23)-c2ccccc21 CHEMBL428064 Potency 631.0 nM
CN1CC=C(c2c[nH]c3ccccc23)CC1 CHEMBL26655 Potency 631.0 nM
NS(=O)(=O)c1ccc(/N=N\c2nc3c(S)ncnc3[nH]2)cc1 CHEMBL1354961 Potency 631.0 nM
c1ccc2oc(-c3cc[nH]n3)nc2c1 CHEMBL3604179 IC50 638.0 nM
Cc1c(C(=O)Nc2ccc(F)cc2Cl)n[nH]c1[Si](C)(C)C CHEMBL3604145 IC50 672.0 nM
COc1cccc(CNc2ccc(S(=O)(=O)Nc3nc4c(C)cccc4s3)cc2)c1O CHEMBL3113169 IC50 690.0 nM
Oc1c(Br)c(Br)c(Br)c(Br)c1Oc1ccc(Br)cc1Br CHEMBL362761 IC50 700.0 nM
Fc1ccc2nc(-c3cc[nH]n3)oc2c1 CHEMBL3604182 IC50 716.0 nM
CCOC(=O)c1[nH]c2cc(Cl)ccc2c1C(=O)CC CHEMBL3622733 Ki 720.0 nM
CNc1oc(-c2ccc3cnccc3c2)nc1C#N CHEMBL3262906 IC50 730.0 nM
CCOC(=O)c1[nH]c2cc(Cl)ccc2c1/C=C/C(=O)NCc1ccccc1Cl CHEMBL4469049 IC50 740.0 nM
CCOC(=O)c1[nH]c2cc(Cl)ccc2c1/C=N/NC(=O)COc1ccc(Cl)cc1 CHEMBL4441796 IC50 740.0 nM
CCOC(=O)c1[nH]c2cc(Cl)ccc2c1/C=C/C(=O)NCc1ccc(OC)cc1 CHEMBL4514408 IC50 750.0 nM
CC1(C)CCC[C@]2(C)[C@H]3C=C4C=C(O)C(=O)C=C4O[C@@]3(C)CC[C@@H]12 CHEMBL157844 IC50 760.0 nM
CCOC(=O)c1[nH]c2cc(Cl)ccc2c1/C=N/NC(=O)Cc1cccnc1 CHEMBL4474382 IC50 780.0 nM
Oc1c(Br)cc(Br)cc1Oc1c(O)c(Br)c(Br)c(Br)c1Br CHEMBL150098 IC50 790.0 nM
Nc1nc2sc3c(c2c(=O)s1)CCCC3 CHEMBL452241 Potency 794.3 nM
CCN1CC=C2C(C#N)=C(N)C(C#N)(C#N)C(c3cc(Cl)ccc3Cl)C2C1 CHEMBL1537386 Potency 794.3 nM
CCC(=O)c1cc(F)c(N2CCN(C(=O)Cc3ccccc3)CC2)cc1C CHEMBL1334275 Potency 794.3 nM
Cc1cc(C)n(-c2nc(Nc3ccccc3)nc(-n3nc(C)cc3C)n2)n1 CHEMBL1449105 Potency 794.3 nM
O=C(O)CN(CCN(CC(=O)O)CC(=O)O)CCN(CC(=O)O)CC(=O)O CHEMBL780 Potency 794.3 nM
CCOC(=O)c1sc(N2C(=O)C(O)=C(C(=O)c3ccco3)C2c2ccccc2)nc1C CHEMBL1464939 Potency 794.3 nM
C/N=C1\N[C@H](c2ccccc2)N(c2ccccc2)S1 CHEMBL1357674 Potency 794.3 nM
CCOC(=O)CSc1nc2nc(C)cc(C)n2n1 CHEMBL1403997 Potency 794.3 nM
Cc1ccc(C2C(C#N)=C(N)SC(N)=C2C#N)c(C)c1 CHEMBL1550509 Potency 794.3 nM
CCOC(=O)c1cnc(-n2nc(C)cc2C)nc1NCCc1ccccc1 CHEMBL1353885 Potency 794.3 nM
O=C(/C=C\c1ccc(O)c(O)c1)OCCc1ccccc1 CHEMBL1397711 Potency 794.3 nM
O=c1cc(O)cc(/C=C\c2ccc(O)c(O)c2)o1 CHEMBL1336985 Potency 794.3 nM
COc1cc(C2C(C(=O)c3ccco3)=C(O)C(=O)N2c2cc(C)on2)cc(Br)c1O CHEMBL1307438 Potency 794.3 nM
COc1cccc(O)c1O CHEMBL1518159 Potency 794.3 nM
Fc1ccc(Nc2ncncc2-c2ccccc2C(F)(F)F)cc1 CHEMBL1590550 Potency 794.3 nM
COc1ccc(C2C(C(=O)c3ccco3)=C(O)C(=O)N2CCc2ccccc2)cc1OC CHEMBL1539091 Potency 794.3 nM
O=C(OC1Cc2c(O)cc(O)cc2OC1c1cc(O)c(=O)c2c(O)c(O)cc(C3Oc4cc(O)cc(O)c4CC3OC(=O)c3cc(O)c(O)c(O)c3)c2c1)c1cc(O)c(O)c(O)c1 CHEMBL1451483 Potency 794.3 nM
C[C@@](N)(Cc1ccc(O)c(O)c1)C(=O)O CHEMBL1452561 Potency 794.3 nM
O=c1ccsn1Cc1ccccc1 CHEMBL572994 Potency 794.3 nM
CCOC(=O)N1CCN(C(=O)CN(c2cccc(C(F)(F)F)c2)S(C)(=O)=O)CC1 CHEMBL1613292 Potency 794.3 nM
O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12 CHEMBL50 Potency 794.3 nM
c1ccc(-c2ccc(-c3ccccn3)nn2)nc1 CHEMBL1453291 Potency 794.3 nM
CN(C)c1ccc(N)cc1 CHEMBL36296 Potency 794.3 nM
C/N=c1\nc(-c2ccccc2)n(-c2ccccc2)s1 CHEMBL161867 Potency 794.3 nM
CC1(C)Cc2c(c(N3CCOCC3)nc3sc(C(=O)N4CCCCC4)c(N)c23)CO1 CHEMBL1530493 Potency 794.3 nM
CN1CCc2cccc3c2[C@@H]1Cc1ccc(O)c(O)c1-3 CHEMBL416288 Potency 794.3 nM
Cc1cc(-c2ccc(/N=N\c3ccc4c(S(=O)(=O)O)cc(S(=O)(=O)O)c(N)c4c3O)c(C)c2)ccc1/N=N\c1ccc2c(S(=O)(=O)O)cc(S(=O)(=O)O)c(N)c2c1O CHEMBL1607905 Potency 794.3 nM
O=C1C=CC(=O)C2=C1C1c3ccccc3C2c2ccccc21 CHEMBL1474701 Potency 794.3 nM
CCCCc1ccc(C2C(C#N)=C(N)SC(N)=C2C#N)s1 CHEMBL1469840 Potency 794.3 nM
COc1ccc(N2CCC(CNS(=O)(=O)c3cccc(C(F)(F)F)c3)C2)cc1 CHEMBL1482010 Potency 794.3 nM
Oc1cc(O)cc(/C=C\c2ccc(O)c(O)c2)c1 CHEMBL1603409 Potency 794.3 nM
Oc1cc(Br)cc2c1Oc1cc(Br)cc(Br)c1O2 CHEMBL185753 IC50 800.0 nM
CNc1oc(-c2ccc(Cl)c(Cl)c2)nc1C#N CHEMBL3262909 IC50 810.0 nM
c1ccc2c(c1)SCc1c-2[nH]c2ccccc12 CHEMBL180917 IC50 810.0 nM
CC1(C)CCC[C@]2(C)[C@H]3C=C4C(=CC(=O)C(O)=C4Cl)O[C@@]3(C)CC[C@@H]12 CHEMBL465616 IC50 830.0 nM
CCOC(=O)c1[nH]c2cc(Cl)ccc2c1C(=O)Cc1ccc(C)cc1 CHEMBL3622742 Ki 830.0 nM
O=C(Nc1ccc2ncccc2c1)c1cc[nH]n1 CHEMBL3604142 IC50 837.0 nM
CC(C)/C=C/c1c(O)cc(-c2cc3ccc(O)cc3o2)cc1O CHEMBL4281040 IC50 840.0 nM
CCCCc1c[nH]nc1C(=O)Nc1ccc(F)cc1Cl CHEMBL3604148 IC50 855.0 nM
O=C(OCC#CCSc1nnc(-c2cccc3ccccc23)o1)c1c[nH]cn1 CHEMBL1270605 Ki 870.0 nM
Oc1cc(Br)c(Br)c2c1Oc1cc(Br)cc(Br)c1O2 CHEMBL185828 IC50 900.0 nM
CC1=CC[C@H]2C(C)(C)CCC[C@]2(C)[C@H]1C[C@@H](OS(=O)(=O)[O-])[C@H](C)CCC/C(C)=C/Cc1cc(O)ccc1O CHEMBL387584 IC50 900.0 nM
CCOC(=O)c1[nH]c2cc(Cl)ccc2c1/C=N/NC(=O)Cc1ccc(OC)c(OC)c1 CHEMBL4546737 IC50 920.0 nM
CCOC(=O)c1[nH]c2cc(Cl)ccc2c1C(C)=O CHEMBL3622732 Ki 930.0 nM
O=C(Nc1ccc(F)cc1)c1cn[nH]n1 CHEMBL3604171 IC50 947.0 nM
CCOC(=O)c1[nH]c2cc(Cl)ccc2c1/C=N/NC(=O)COc1ccc(Cl)cc1Cl CHEMBL4468923 IC50 990.0 nM