COc1cccc(-c2ccc(Cn3c(CC(C)(C)C(=O)O)c(SC(C)(C)C)c4cc(OCc5ccc(C)cn5)ccc43)cc2)n1 CHEMBL1922653 IC50 0.3 nM
Cc1cnc(COc2ccc3nc([C@H]4CCCC[C@H]4C(=O)O)n(Cc4ccc(N5CCC(F)CC5)cc4F)c3c2)c(F)c1 CHEMBL3667000 Ki 0.34 nM
Cc1ccc(COc2ccc3c(c2)c(SC(C)(C)C)c(CC(C)(C)C(=O)O)n3Cc2ccc(-c3cc(C(F)(F)F)ccn3)cc2)nc1 CHEMBL1922655 IC50 0.4 nM
CCOc1nc(-c2ccc(Cn3c(CC(C)(C)C(=O)O)c(SC(C)(C)C)c4cc(OCc5ccc(C)cn5)ccc43)cc2)cs1 CHEMBL1922656 IC50 0.4 nM
Cc1ccc(COc2ccc3c(c2)c(SC(C)(C)C)c(CC(C)(C)C(=O)O)n3Cc2ccc(-c3ccc(C(F)(F)F)nc3)cc2)nc1 CHEMBL1922657 IC50 0.4 nM
Cc1ccc(COc2ccc3c(c2)c(SC(C)(C)C)c(CC(C)(C)C(=O)O)n3Cc2ccc(-c3ccc(F)cn3)cc2)nc1 CHEMBL1922663 IC50 0.4 nM
Nc1cnc(-c2ccc(C3CCC3)c(Oc3cc(N)nc(Cc4ccccc4)n3)c2F)cn1 CHEMBL3704300 Ki 0.4 nM
Nc1cnc(-c2ccc(-c3cccnc3S(=O)(=O)C3CCCCC3)cc2F)cn1 CHEMBL3700843 Ki 0.4 nM
Cc1cnc(COc2ccc3nc([C@H]4CCCC[C@H]4C(=O)O)n(Cc4ccc(N5CCC(F)CC5)cc4)c3c2)c(F)c1 CHEMBL3667001 Ki 0.42 nM
Cc1cnc(COc2ccc3nc([C@H]4CCCC[C@H]4C(=O)O)n(Cc4ccc(-c5ccc(C(F)(F)F)cc5)cc4)c3c2)c(F)c1 CHEMBL3666967 Ki 0.47 nM
CC(C)(C)Sc1c(CC(C)(C)C(=O)[O-])n(Cc2ccc(Cl)cc2)c2ccc(OCc3ccc4ccccc4n3)cc12 CHEMBL313489 IC50 0.5 nM
COc1ccc(-c2ccc(Cn3c(CC(C)(C)C(=O)O)c(SC(C)(C)C)c4cc(OCc5ccccn5)ccc43)cc2)cn1 CHEMBL557527 IC50 0.5 nM
COc1ccc(-c2ccc(Cn3c(CC(C)(C)C(=O)O)c(SC(C)(C)C)c4cc(OCc5ccc(C)cn5)ccc43)cc2)cn1 CHEMBL1922532 IC50 0.5 nM
COc1ccc(-c2ccc(Cn3c(CC(C)(C)C(=O)O)c(SC(C)(C)C)c4cc(OCc5cccc(C)n5)ccc43)cc2)cn1 CHEMBL1922642 IC50 0.5 nM
Cc1ccc(COc2ccc3c(c2)c(SC(C)(C)C)c(CC(C)(C)C(=O)O)n3Cc2ccc(-c3ccc(C(F)(F)F)cn3)cc2)nc1 CHEMBL1922658 IC50 0.5 nM
Cc1ccc(COc2ccc3c(c2)c(SC(C)(C)C)c(CC(C)(C)C(=O)O)n3Cc2ccc(-c3cccc(C(F)(F)F)n3)cc2)nc1 CHEMBL1922659 IC50 0.5 nM
Cc1ccc(COc2ccc3c(c2)c(SC(C)(C)C)c(CC(C)(C)C(=O)O)n3Cc2ccc(-c3ccc(C)cn3)cc2)nc1 CHEMBL1922662 IC50 0.5 nM
Cc1ccc(COc2ccc3c(c2)c(SC(C)(C)C)c(CC(C)(C)C(=O)O)n3Cc2ccc(-c3cccnc3)cc2)nc1 CHEMBL1922665 IC50 0.5 nM
Nc1cnc(-c2ccc(C3CCC3)c(Oc3nc(N)c4ccccc4n3)c2F)cn1 CHEMBL3659304 Ki 0.5 nM
CC(C)C(C)(c1ccc(-c2cnc(N)nc2)cc1)c1ccc(-c2ccc(C(C)(C)O)nn2)cn1 CHEMBL5283430 IC50 0.5 nM
Cc1cnc(COc2ccc3nc([C@H]4CCCC[C@@H]4C(=O)O)n(Cc4c(F)cc(Br)cc4F)c3c2)c(F)c1 CHEMBL3666952 Ki 0.52 nM
CCc1ccc(COc2ccc3c(c2)c(SC(C)(C)C)c(CC(C)(C)C(=O)O)n3Cc2ccc(-c3ccc(OC)nc3)cc2)nc1 CHEMBL1922643 IC50 0.6 nM
COc1ccc(-c2ccc(Cn3c(CC(C)(C)C(=O)O)c(SC(C)(C)C)c4cc(OCc5ccc(C)c(C)n5)ccc43)cc2)cn1 CHEMBL1922645 IC50 0.6 nM
CCOc1cccc(-c2ccc(Cn3c(CC(C)(C)C(=O)O)c(SC(C)(C)C)c4cc(OCc5ccc(C)cn5)ccc43)cc2)n1 CHEMBL1922661 IC50 0.6 nM
Cc1ccc(COc2ccc3c(c2)c(SC(C)(C)C)c(CC(C)(C)C(=O)O)n3Cc2ccc(-c3cncc(F)c3)cc2)nc1 CHEMBL1922664 IC50 0.6 nM
Cc1ccc(COc2ccc3c(c2)c(SC(C)(C)C)c(CC(C)(C)C(=O)O)n3Cc2ccc(-c3ccccn3)cc2)nc1 CHEMBL1922666 IC50 0.6 nM
COc1cnc(-c2ccc(Cn3c(CC(C)(C)C(=O)O)c(SC(C)(C)C)c4cc(OCc5ccc(C)cn5)ccc43)cc2)nc1 CHEMBL1229205 IC50 0.6 nM
Nc1cnc(-c2ccc(-c3ccccc3-c3ccc(-c4cnc(N)cn4)c(F)c3)cc2F)cn1 CHEMBL3697283 Ki 0.6 nM
Nc1cnc(-c2ccc(-c3cccnc3S(=O)(=O)C3CCCC3)cc2F)cn1 CHEMBL3700845 Ki 0.6 nM
Cc1cnc(COc2ccc3nc([C@H]4CCCC[C@H]4C(=O)O)n(Cc4c(F)cc(Br)cc4F)c3c2)c(F)c1 CHEMBL3929588 Ki 0.61 nM
Cc1cnc(COc2ccc3nc([C@@H]4CCCC[C@@H]4C(=O)O)n(Cc4c(F)cc(Br)cc4F)c3c2)c(F)c1 CHEMBL3666951 Ki 0.61 nM
CCC(CC)(Cc1nc2ccc(OCc3ncc(C)cc3F)cc2n1Cc1ccc(Br)cc1)C(=O)O CHEMBL3666964 Ki 0.64 nM
Cc1cnc(COc2ccc3nc([C@H]4CCCC[C@H]4C(=O)O)n(Cc4c(F)cc(-c5ccc(C(F)(F)F)cc5)cc4F)c3c2)c(F)c1 CHEMBL3666965 Ki 0.66 nM
COc1ccc(-c2ccc(Cn3c(CC(C)(C)C(=O)O)c(SC(C)(C)C)c4cc(OCc5cnc6ccccc6n5)ccc43)cc2)cn1 CHEMBL1922524 IC50 0.7 nM
COc1ccc(-c2ccc(Cn3c(CC(C)(C)C(=O)O)c(SC(C)(C)C)c4cc(OCc5ccc6cc(F)ccc6n5)ccc43)cc2)cn1 CHEMBL1922525 IC50 0.7 nM
COc1ccc(-c2ccc(Cn3c(CC(C)(C)C(=O)O)c(SC(C)(C)C)c4cc(OCc5ccc(Cl)cn5)ccc43)cc2)cn1 CHEMBL1922646 IC50 0.7 nM
COc1ccc(COc2ccc3c(c2)c(SC(C)(C)C)c(CC(C)(C)C(=O)O)n3Cc2ccc(-c3ccc(OC)nc3)cc2)nc1 CHEMBL1922647 IC50 0.7 nM
CCOc1ccc(-c2ccc(Cn3c(CC(C)(C)C(=O)O)c(SC(C)(C)C)c4cc(OCc5ccc(C)cn5)ccc43)cc2)cn1 CHEMBL1922660 IC50 0.7 nM
CC(C)(C)NS(=O)(=O)c1ccccc1-c1cnc(-c2cnc(N)nc2)c(F)c1 CHEMBL3697342 Ki 0.7 nM
CC(C)S(=O)(=O)c1ncccc1-c1ccc(-c2cnc3[nH]ccc3c2)c(F)c1 CHEMBL3700861 Ki 0.7 nM
CC(C)C(C)(c1ccc(OCc2ccccn2)cc1)c1ccc(-c2ccc(C(C)(C)O)nn2)cn1 CHEMBL5269712 IC50 0.7 nM
Cc1ccn(-c2ccc(Cl)cc2-c2nc3cc(-c4cnc(N)nc4)ccc3n2C(C)(C)C)n1 CHEMBL5274418 IC50 0.7 nM
Cc1ccc(COc2ccc3nc([C@@H]4CCCC[C@@H]4C(=O)O)n(Cc4ccc(Br)cc4F)c3c2)nc1 CHEMBL3662244 Ki 0.74 nM
Cc1ccc(COc2ccc3nc([C@H]4CCCC[C@H]4C(=O)O)n(Cc4ccc(Br)cc4F)c3c2)nc1 CHEMBL3662245 Ki 0.74 nM
COc1ccc(-c2ccc(Cn3c(CC(C)(C)C(=O)O)c(SC(C)(C)C)c4cc(OCc5ccc6ccccc6n5)ccc43)cc2)cn1 CHEMBL1922523 IC50 0.8 nM
COc1cccnc1-c1ccc(Cn2c(CC(C)(C)C(=O)O)c(SC(C)(C)C)c3cc(OCc4ccc(C)cn4)ccc32)cc1 CHEMBL1922654 IC50 0.8 nM
O=c1[nH]nc(-c2ccc(OCc3ccc4ccccc4n3)cc2[C@@]2(c3ccccc3)C[C@H]3CC[C@H]2C3)o1 CHEMBL2031657 IC50 0.8 nM
Cc1cnc(COc2ccc3nc([C@@H]4CCCC[C@@H]4C(=O)O)n(Cc4ccc(N5CCC(F)CC5)cc4F)c3c2)c(F)c1 CHEMBL3666999 Ki 0.82 nM
Cc1cnc(COc2ccc3nc([C@@H]4CCCC[C@@H]4C(=O)O)n(Cc4c(F)cc(N5CCC(F)CC5)cc4F)c3c2)c(F)c1 CHEMBL3666998 Ki 0.84 nM
Cc1cnc(COc2ccc3nc([C@H]4CCCC[C@H]4C(=O)O)n(Cc4c(F)cc(N5CCC(F)CC5)cc4F)c3c2)c(F)c1 CHEMBL3938018 Ki 0.84 nM
CNc1nc(C)cc(Oc2c(C3CCC3)ccc(-c3cnc(N)cn3)c2F)n1 CHEMBL3659301 Ki 0.9 nM
CC(C)(C)n1c(-c2ccccc2C(=O)Nc2ccncc2)nc2cc(-c3cnc(N)nc3)ccc21 CHEMBL3681322 IC50 0.91 nM
Cc1ccc(COc2ccc3nc([C@H]4CCCC[C@H]4C(=O)O)n(Cc4ccc(N5CCC(F)(F)C5)cc4F)c3c2)nc1 CHEMBL3666989 Ki 0.96 nM
Nc1cnc(-c2ccc(-c3ccccc3S(=O)(=O)NC[C@H](O)c3ccccc3)cc2F)cn1 CHEMBL3985496 Ki 1.0 nM
CC(C)(C)[C@H](CO)NS(=O)(=O)c1ccccc1-c1ccc(-c2cnc(N)cn2)c(F)c1 CHEMBL3940195 Ki 1.0 nM
Nc1cnc(-c2ccc(-c3ccccc3S(=O)(=O)N[C@@H]3c4ccccc4C[C@H]3O)cc2F)cn1 CHEMBL4112424 Ki 1.0 nM
C[C@H](CC#N)NS(=O)(=O)c1ccccc1-c1ccc(-c2cnc(N)cn2)c(F)c1 CHEMBL4109863 Ki 1.0 nM
Nc1cnc(-c2ccc(C3CCC3)c(Oc3nccc(-c4ccccc4)n3)c2F)cn1 CHEMBL3704245 Ki 1.0 nM
Nc1cnc(-c2ccc(C3CCC3)c(Oc3nccc(-c4cccs4)n3)c2F)cn1 CHEMBL3704248 Ki 1.0 nM
COc1nc(N)cc(Oc2c(C3CCC3)ccc(-c3cnc(N)cn3)c2F)n1 CHEMBL3704256 Ki 1.0 nM
CC(C)(C)NS(=O)(=O)c1ccccc1-c1ccc(-c2cnc(N)cn2)c(F)c1 CHEMBL3688400 Ki 1.0 nM
Nc1cnc(-c2ccc(-c3ccccc3S(=O)(=O)NC3CCCCC3)cc2F)cn1 CHEMBL3688402 Ki 1.0 nM
CC(NS(=O)(=O)c1ccccc1-c1ccc(-c2cnc(N)cn2)c(F)c1)C(F)(F)F CHEMBL3688404 Ki 1.0 nM
CC(C)(NS(=O)(=O)c1ccccc1-c1ccc(-c2cnc(N)cn2)c(F)c1)C(F)(F)F CHEMBL3688409 Ki 1.0 nM
C[C@@H](NS(=O)(=O)c1ccccc1-c1ccc(-c2cnc(N)cn2)c(F)c1)C(F)(F)F CHEMBL3688415 Ki 1.0 nM
Nc1cnc(-c2ccc(-c3ccccc3S(=O)(=O)N[C@@H]3CCc4ccccc43)cc2F)cn1 CHEMBL3688417 Ki 1.0 nM
Nc1cnc(-c2ccc(-c3ccccc3S(=O)(=O)Nc3ccccc3)cc2F)cn1 CHEMBL3639872 Ki 1.0 nM
CCN(CC)S(=O)(=O)c1ccccc1-c1ccc(-c2cnc(N)cn2)c(F)c1 CHEMBL3688438 Ki 1.0 nM
Nc1cnc(-c2ccc(-c3ccccc3S(=O)(=O)N3CCCC(F)(F)C3)cc2F)cn1 CHEMBL3688441 Ki 1.0 nM
Nc1cnc(-c2ccc(-c3ccccc3S(=O)(=O)N3CCC(O)(C(F)(F)F)CC3)cc2F)cn1 CHEMBL3688446 Ki 1.0 nM
Nc1cnc(-c2ccc(-c3ccccc3S(=O)(=O)N3CCC(CO)CC3)cc2F)cn1 CHEMBL3688458 Ki 1.0 nM
Nc1cnc(-c2ccc(-c3ccccc3S(=O)(=O)N3CCC(CCO)CC3)cc2F)cn1 CHEMBL3688459 Ki 1.0 nM
Nc1cnc(-c2ccc(-c3ccccc3S(=O)(=O)N[C@@H](CO)[C@@H](O)c3ccccc3)cc2F)cn1 CHEMBL3688468 Ki 1.0 nM
Nc1cnc(-c2ccc(-c3ccccc3S(=O)(=O)N[C@@H](CO)c3ccccc3)cc2F)cn1 CHEMBL3688472 Ki 1.0 nM
C[C@H](NS(=O)(=O)c1ccccc1-c1ccc(-c2cnc(N)cn2)c(F)c1)[C@@H](O)c1ccccc1 CHEMBL3688473 Ki 1.0 nM
Nc1cnc(-c2ccc(-c3ccccc3S(=O)(=O)NCC3CC3)cc2F)cn1 CHEMBL3688480 Ki 1.0 nM
CC(C)(CO)NS(=O)(=O)c1ccccc1-c1ccc(-c2cnc(N)cn2)c(F)c1 CHEMBL3688486 Ki 1.0 nM
CC(C)[C@H](CO)NS(=O)(=O)c1ccccc1-c1ccc(-c2cnc(N)cn2)c(F)c1 CHEMBL3700900 Ki 1.0 nM
Nc1cnc(-c2ccc(-c3ccccc3S(=O)(=O)N[C@H](CO)Cc3ccccc3)cc2F)cn1 CHEMBL3688495 Ki 1.0 nM
Nc1cnc(-c2ccc(-c3ccccc3S(=O)(=O)N[C@H]3CCCC[C@@H]3O)cc2F)cn1 CHEMBL3688497 Ki 1.0 nM
Nc1cnc(-c2ccc(-c3ccccc3S(=O)(=O)N[C@@H]3CCCC[C@@H]3CO)cc2F)cn1 CHEMBL3688498 Ki 1.0 nM
Nc1cnc(-c2ccc(-c3ccccc3S(=O)(=O)N3CCc4[nH]ncc4C3)cc2F)cn1 CHEMBL3688502 Ki 1.0 nM
Nc1cnc(-c2ccc(-c3ccccc3S(=O)(=O)NCCCCCCO)cc2F)cn1 CHEMBL3688506 Ki 1.0 nM
Nc1cnc(-c2ccc(-c3ccccc3S(=O)(=O)N[C@H]3CC[C@@H](N)CC3)cc2F)cn1 CHEMBL3688507 Ki 1.0 nM
Nc1cnc(-c2ccc(-c3ccccc3S(=O)(=O)N(CCO)C3CCCCC3)cc2F)cn1 CHEMBL3688508 Ki 1.0 nM
Nc1cnc(-c2ccc(-c3ccccc3S(=O)(=O)N(C3CCOCC3)C3CC3)cc2F)cn1 CHEMBL3688512 Ki 1.0 nM
CC(C)N(CCO)S(=O)(=O)c1ccccc1-c1ccc(-c2cnc(N)cn2)c(F)c1 CHEMBL3688513 Ki 1.0 nM
CC(CO)(CO)NS(=O)(=O)c1ccccc1-c1ccc(-c2cnc(N)cn2)c(F)c1 CHEMBL3688516 Ki 1.0 nM
CC(C)(C)OC(=O)NCCNS(=O)(=O)c1ccccc1-c1ccc(-c2cnc(N)cn2)c(F)c1 CHEMBL3688518 Ki 1.0 nM
Nc1cnc(-c2ccc(-c3ccccc3S(=O)(=O)N[C@H]3c4ccccc4C[C@@H]3O)cc2F)cn1 CHEMBL3688525 Ki 1.0 nM
Nc1cnc(-c2ccc(-c3ccccc3S(=O)(=O)Nc3ccc(C(F)(F)F)nc3)cc2F)cn1 CHEMBL3688526 Ki 1.0 nM
Nc1cnc(-c2ccc(-c3ccccc3S(=O)(=O)N3CCC(c4c[nH]cn4)CC3)cc2F)cn1 CHEMBL3688527 Ki 1.0 nM
CC1(NS(=O)(=O)c2ccccc2-c2ccc(-c3cnc(N)cn3)c(F)c2)COC1 CHEMBL3688535 Ki 1.0 nM
COC[C@H](C)NS(=O)(=O)c1ccccc1-c1ccc(-c2cnc(N)cn2)c(F)c1 CHEMBL3688537 Ki 1.0 nM
Nc1cnc(-c2ccc(-c3ccc(C(F)(F)F)cc3S(=O)(=O)N3CCNC(=O)C3)cc2F)cn1 CHEMBL3688566 Ki 1.0 nM
CCNS(=O)(=O)c1cc(C(F)(F)F)ccc1-c1ccc(-c2cnc(N)cn2)c(F)c1 CHEMBL3688567 Ki 1.0 nM
CN1CCN(S(=O)(=O)c2cc(C(F)(F)F)ccc2-c2ccc(-c3cnc(N)cn3)c(F)c2)CC1 CHEMBL3688568 Ki 1.0 nM
Nc1cnc(-c2ccc(-c3ccccc3Sc3ncncc3N)cc2F)cn1 CHEMBL3688573 Ki 1.0 nM
Nc1cnc(-c2ccc(-c3ccccc3Sc3ccnc(N)n3)cc2F)cn1 CHEMBL3688598 Ki 1.0 nM
Nc1ncc(-c2ccc(-c3ccccc3S(=O)(=O)N3CC(O)(C(F)(F)F)C3)cc2F)cn1 CHEMBL3693060 Ki 1.0 nM
CCC(C)(C)NS(=O)(=O)c1ccccc1-c1ccc(-c2ccc(N)nc2)c(F)c1 CHEMBL3693093 Ki 1.0 nM
CC1(NS(=O)(=O)c2ccccc2-c2ccc(-c3ccc(N)nc3)c(F)c2)CCC1 CHEMBL3693096 Ki 1.0 nM
C[C@@H](CO)NS(=O)(=O)c1ccccc1-c1ccc(-c2cnc3[nH]ccc3c2)c(F)c1 CHEMBL3693105 Ki 1.0 nM
C[C@H](CO)NS(=O)(=O)c1ccccc1-c1ccc(-c2cnc3[nH]ccc3c2)c(F)c1 CHEMBL3693106 Ki 1.0 nM
O=S(=O)(NCCO)c1ccccc1-c1ccc(-c2cnc3[nH]ccc3c2)c(F)c1 CHEMBL3693109 Ki 1.0 nM
CC(C)(C)NS(=O)(=O)c1ccccc1-c1ccc(-c2cnc3[nH]ccc3c2)c(F)c1 CHEMBL3693110 Ki 1.0 nM
CC(C)(C)NS(=O)(=O)c1ccccc1-c1ccc(-c2cnc3[nH]ccc3n2)c(F)c1 CHEMBL3693114 Ki 1.0 nM
CCN(CC)S(=O)(=O)c1ccccc1-c1ccc(-c2cnc3[nH]ccc3n2)c(F)c1 CHEMBL3693116 Ki 1.0 nM
O=S(=O)(c1ccccc1-c1ccc(-c2cnc3[nH]ccc3n2)c(F)c1)N1CCCCC1 CHEMBL3693117 Ki 1.0 nM
C[C@@H](CO)NS(=O)(=O)c1ccccc1-c1ccc(-c2cnc3[nH]ccc3n2)c(F)c1 CHEMBL3693120 Ki 1.0 nM
CNS(=O)(=O)c1ccccc1-c1ccc(-c2cnc3[nH]ccc3n2)c(F)c1 CHEMBL3693121 Ki 1.0 nM
C[C@H](CO)NS(=O)(=O)c1ccccc1-c1ccc(-c2cnc3[nH]ccc3n2)c(F)c1 CHEMBL3693122 Ki 1.0 nM
O=S1(=O)CCN(S(=O)(=O)c2ccccc2-c2ccc(-c3cnc4c(c3)OCCN4)c(F)c2)CC1 CHEMBL3693132 Ki 1.0 nM
CC(C)(C)NS(=O)(=O)c1ccccc1-c1ccc(-c2cnc3c(c2)OCCN3)c(F)c1 CHEMBL3693133 Ki 1.0 nM
CC(C)(C)NS(=O)(=O)c1ccccc1-c1ccc(-c2cnc3c(c2)CCN3)c(F)c1 CHEMBL3693170 Ki 1.0 nM
COc1nc(-c2ccc(-c3ccccc3S(=O)(=O)NC(C)(C)C)cc2F)cnc1N CHEMBL3693172 Ki 1.0 nM
CC(C)(C)NS(=O)(=O)c1ccccc1-c1ccc(-c2cnc(N)c(C#N)n2)c(F)c1 CHEMBL3693173 Ki 1.0 nM
CC(C)(C)NS(=O)(=O)c1ccccc1-c1ccc(-c2nnc(N)s2)c(F)c1 CHEMBL3693177 Ki 1.0 nM
CC(C)(C)NS(=O)(=O)c1ccccc1-c1ccc(-c2cnc(N)c(Cl)n2)c(F)c1 CHEMBL3693180 Ki 1.0 nM
CC(C)(C)NS(=O)(=O)c1ccccc1-c1ccc(-c2cnc(N)c(Br)n2)c(F)c1 CHEMBL3693181 Ki 1.0 nM
Cc1nc(-c2ccc(-c3ccccc3S(=O)(=O)NC(C)(C)C)cc2F)cnc1N CHEMBL3693184 Ki 1.0 nM
CC(C)(C)NS(=O)(=O)c1ccccc1-c1ccc(-c2cnc3[nH]cc(CO)c3c2)c(F)c1 CHEMBL3693194 Ki 1.0 nM
Nc1nccc(Oc2ccccc2-c2ccc(-c3cnc4[nH]ccc4c3)c(F)c2)n1 CHEMBL3697207 Ki 1.0 nM
Nc1ccnc(Oc2ccccc2-c2ccc(-c3cnc4[nH]ccc4c3)c(F)c2)n1 CHEMBL3697208 Ki 1.0 nM
Nc1cnc(-c2ccc(-c3ccccc3Oc3cc(N)ncn3)cc2F)cn1 CHEMBL3697219 Ki 1.0 nM
Nc1cnc(-c2ccc(-c3ccc(C(F)(F)F)cc3Oc3nccc(N)n3)cc2F)cn1 CHEMBL3697238 Ki 1.0 nM
N#CCCn1cc(-c2nc(C3(c4ccc(-c5cnc(N)nc5)cc4)CCC3)no2)cn1 CHEMBL4080876 IC50 1.0 nM
CN(C(=O)Cn1cc(-c2nc(C3(c4ccc(-c5cnc(N)nc5)cc4)CCC3)no2)cn1)C(C)(C)C CHEMBL4088763 IC50 1.0 nM
COc1ccc(-c2ccc(Cn3c(CC(C)(C)C(=O)O)c(SC(C)(C)C)c4cc(OCc5ncccc5C)ccc43)cc2)cn1 CHEMBL1922530 IC50 1.1 nM
S=c1[nH]nc(-c2ccc(OCc3ccc4ccccc4n3)cc2[C@]2(c3ccccc3)C[C@H]3CC[C@H]2C3)o1 CHEMBL2031647 IC50 1.1 nM
COc1cccc([C@]2(c3cc(OCc4ccc5ccccc5n4)ccc3-c3n[nH]c(=O)o3)C[C@H]3CC[C@H]2C3)c1 CHEMBL2031658 IC50 1.1 nM
CN(C)C(=O)Cn1cc(-c2nc([C@@](C)(c3ccc(-c4ccc(N)nc4)cc3)C3CC3)no2)cn1 CHEMBL3417524 IC50 1.1 nM
Cn1ccc(COc2cc(F)c3nc([C@@H]4CCCC[C@@H]4C(=O)O)n(Cc4ccc(Br)cc4)c3c2)n1 CHEMBL3666924 Ki 1.1 nM
Cc1cnc(COc2ccc3nc([C@H]4CCCC[C@H]4C(=O)O)n(Cc4ccc(Br)cc4)c3c2)c(F)c1 CHEMBL3895376 Ki 1.1 nM
Cc1ccc(COc2ccc3nc([C@H]4CCCC[C@H]4C(=O)O)n(Cc4c(F)cc(Br)cc4F)c3c2)nc1 CHEMBL3666954 Ki 1.1 nM
Cc1cnc(COc2ccc3nc([C@H]4CCCC[C@H]4C(=O)O)n(Cc4ccc(N5CCC(C)CC5)cc4F)c3c2)c(F)c1 CHEMBL3957641 Ki 1.1 nM
Nc1cnc(-c2ccc(C3CCC3)c(Oc3ccnc(-c4ccccc4)n3)c2F)cn1 CHEMBL3704298 Ki 1.1 nM
Cn1ccc(COc2cc(F)c3nc([C@H]4CCCC[C@H]4C(=O)O)n(Cc4ccc(Br)cc4)c3c2)n1 CHEMBL3963509 Ki 1.1 nM
Cc1cnc(COc2ccc3nc([C@@H]4CCCC[C@@H]4C(=O)O)n(Cc4ccc(Br)cc4)c3c2)c(F)c1 CHEMBL3666953 Ki 1.1 nM
Cc1cnc(COc2ccc3nc([C@@H]4CCCC[C@@H]4C(=O)O)n(Cc4ccc(N5CCC(C)CC5)cc4F)c3c2)c(F)c1 CHEMBL3667002 Ki 1.1 nM
COc1cncc(-c2ccc(C(C)(c3ccc(-c4ccc(C(C)(C)O)nn4)cn3)C(C)C)cc2)c1 CHEMBL5278870 IC50 1.1 nM
COc1ccc(-c2ccc(Cn3c(CC(C)(C)C(=O)O)c(SC(C)(C)C)c4cc(OCc5ncc(C)cc5C)ccc43)cc2)cn1 CHEMBL1922644 IC50 1.2 nM
CN(C)C(=O)Cn1cc(-c2nc([C@@](C)(c3ccc(-c4cnc(N)cn4)cc3)C3CC3)no2)cn1 CHEMBL3417526 IC50 1.2 nM
Nc1ncc(-c2ccc(C3(c4noc(-c5ccc(N6CC[C@@H](O)C6)nc5)n4)CCC3)cn2)cn1 CHEMBL3684717 IC50 1.2 nM
Cc1cnc(COc2ccc3nc([C@@H]4CCCC[C@@H]4C(=O)O)n(Cc4ccc(N5CCC(C)CC5)cc4)c3c2)c(F)c1 CHEMBL3667003 Ki 1.2 nM
Nc1cnc(-c2ccc(C3CCC3)c(Oc3nccc(N4CCC5(CC4)OCCCO5)n3)c2F)cn1 CHEMBL3659272 Ki 1.2 nM
Cc1cnc(COc2ccc3nc([C@H]4CCCC[C@H]4C(=O)O)n(Cc4ccc(N5CCC(C)CC5)cc4)c3c2)c(F)c1 CHEMBL3897521 Ki 1.2 nM
Cn1cc(-c2nc([C@@](C)(c3ccc(-c4cnc(N)nc4)cc3)C3CC3)no2)cn1 CHEMBL3417520 IC50 1.3 nM
Cc1ccc(COc2ccc3nc([C@@H]4CCCC[C@@H]4C(=O)O)n(Cc4ccc(-c5ccc(C(F)(F)F)cc5)cc4)c3c2)nc1 CHEMBL3667018 Ki 1.3 nM
Cc1cnc(COc2ccc3nc([C@@H]4CCCC[C@@H]4C(=O)O)n(Cc4ccc(N5CCCCC5)cc4)c3c2)c(F)c1 CHEMBL3667004 Ki 1.3 nM
CC(C)c1nccc(Oc2c(C3CCC3)ccc(-c3cnc(N)cn3)c2F)n1 CHEMBL3704289 Ki 1.3 nM
Cc1nc(N)cc(Oc2c(C3CCC3)ccc(-c3cnc(N)cn3)c2F)n1 CHEMBL3704294 Ki 1.3 nM
CC(C)(C)OC(=O)NCCNc1ccnc(Oc2c(C3CCC3)ccc(-c3cnc(N)cn3)c2F)n1 CHEMBL3704303 Ki 1.3 nM
CC(C)CNc1nccc(Oc2c(C3CCC3)ccc(-c3cnc(N)cn3)c2F)n1 CHEMBL3659293 Ki 1.3 nM
Cc1cnc(COc2ccc3nc([C@H]4CCCC[C@H]4C(=O)O)n(Cc4ccc(N5CCCCC5)cc4)c3c2)c(F)c1 CHEMBL3963003 Ki 1.3 nM
CC(=O)N1c2ccccc2C[C@H]1COc1ccc2c(c1)c(SC(C)(C)C)c(CC(C)(C)C(=O)O)n2Cc1ccc(Cl)cc1 CHEMBL610185 IC50 1.4 nM
COc1ccc(-c2ccc(Cn3c(CC(C)(C)C(=O)O)c(SC(C)(C)C)c4cc(OCc5cn6ccccc6n5)ccc43)cc2)cn1 CHEMBL1922528 IC50 1.4 nM
Nc1ncc(-c2ccc(C3(c4noc(-c5ccccc5)n4)CCC3)cc2)cn1 CHEMBL3417414 IC50 1.4 nM
Cc1ccc(COc2ccc3nc([C@@H]4CCCC[C@@H]4C(=O)O)n(Cc4ccc(Br)cc4)c3c2)nc1 CHEMBL3667014 Ki 1.4 nM
Cc1ccc(COc2ccc3nc([C@H]4CCCC[C@H]4C(=O)O)n(Cc4ccc(OC(F)(F)F)cc4)c3c2)nc1 CHEMBL3662259 Ki 1.4 nM
Cn1cc(F)c(COc2ccc3nc([C@H]4CCCC[C@H]4C(=O)O)n(Cc4ccc(OC(F)(F)F)cc4F)c3c2)n1 CHEMBL3902241 Ki 1.4 nM
Cn1ccc(COc2ccc3nc([C@H]4CCCC[C@H]4C(=O)O)n(Cc4cccc(-c5ccc(C(F)(F)F)cc5)c4)c3c2)n1 CHEMBL3964743 Ki 1.4 nM
Nc1ccnc(Oc2c(C3CCC3)ccc(-c3cnc4c(c3)OCCN4)c2F)n1 CHEMBL3659257 Ki 1.4 nM
Nc1cnc(-c2ccc(-c3ccccc3Oc3ccnc(N)c3)cc2F)cn1 CHEMBL3697312 Ki 1.4 nM
Cc1ccc(COc2ccc3nc(C4CCCC[C@@H]4C(=O)O)n(Cc4ccc(Br)cc4)c3c2)nc1 CHEMBL3662239 Ki 1.4 nM
Cn1cc(F)c(COc2ccc3nc([C@@H]4CCCC[C@@H]4C(=O)O)n(Cc4ccc(OC(F)(F)F)cc4F)c3c2)n1 CHEMBL3666916 Ki 1.4 nM
Cn1ccc(COc2ccc3nc([C@@H]4CCCC[C@@H]4C(=O)O)n(Cc4cccc(-c5ccc(C(F)(F)F)cc5)c4)c3c2)n1 CHEMBL3666976 Ki 1.4 nM
CCOc1ccc(-c2ccc(Cn3c(CC(C)(C)C(=O)O)c(C(=O)CC(C)(C)C)c4cc(OCc5ccc(C)cn5)ccc43)cc2)cn1 CHEMBL1922671 IC50 1.5 nM
CC(C)Nc1ccc(-c2nc(C3(c4ccc(-c5cnc(N)nc5)nc4)CCC3)no2)cn1 CHEMBL3689122 IC50 1.5 nM
CC(C)(C)n1c(-c2ccccc2C(=O)Nc2cccnc2)nc2cc(-c3cnc(N)nc3)ccc21 CHEMBL3681336 IC50 1.5 nM
C[C@H](NC(=O)c1cc(C(F)(F)F)ccc1-c1ccc(-c2cnc(N)cn2)c(F)c1)C(F)(F)F CHEMBL3700825 Ki 1.5 nM
C[C@@](c1ccc(-c2cnc(N)nc2)nc1)(c1noc(-c2cnn(C3COC3)c2)n1)C1CC1 CHEMBL4088331 IC50 1.5 nM
CC(C)(C)Sc1c(CC(C)(C)C(=O)O)n(Cc2ccc(Cl)cc2)c2ccc(OCc3ccc4ccccc4n3)cc12 CHEMBL16596 IC50 1.6 nM
Cc1nc(-c2ccc(OCc3ccc4ccccc4n3)cc2[C@]2(c3ccccc3)C[C@H]3CC[C@H]2C3)no1 CHEMBL2031651 IC50 1.6 nM
CC(C)[C@](C)(c1ccc(-c2cnc(N)nc2)cc1)c1noc(-c2cnn(C)c2)n1 CHEMBL3417518 IC50 1.6 nM
O=C(O)[C@@H]1CCCC[C@@H]1c1nc2cc(OCc3ccc4ccccc4n3)ccc2n1Cc1ccc(Br)cc1 CHEMBL3683284 Ki 1.6 nM
Nc1cnc(-c2ccc(-c3ccccc3Sc3ccncn3)cc2F)cn1 CHEMBL3700784 Ki 1.6 nM
Cc1cc(-c2ccc(C(=O)[C@@H]3CCCC[C@H]3C(=O)Nc3cnn(C)c3C(=O)NOC(C)(C)C)cc2)[nH]n1 CHEMBL4563459 fIC50 1.6 nM
CC(C)(C)Sc1c(CC(C)(C)C(=O)O)n(Cc2ccc(Cl)cc2)c2ccc(OCc3ccccn3)cc12 CHEMBL38958 IC50 1.7 nM
CC(=O)N1c2ccccc2C[C@H]1COc1ccc2c(c1)c(SC(C)(C)C)c(CC(C)(C)C(=O)O)n2Cc1ccc(-c2ccc(F)cn2)cc1 CHEMBL595872 IC50 1.7 nM
COc1ccc(-c2ccc(Cn3c(CC(C)(C)C(=O)O)c(SC(C)(C)C)c4cc(OCc5ccc6cc(C)ccc6n5)ccc43)cc2)cn1 CHEMBL1922527 IC50 1.7 nM
CC(C)n1nnc(-c2ccc(OCc3ccc4ccccc4n3)cc2[C@]2(c3ccccc3)C[C@H]3CC[C@H]2C3)n1 CHEMBL2031655 IC50 1.7 nM
CN(C)C(=O)Cn1cc(-c2nc([C@@](C)(c3ccc(-c4cnc(N)nc4)cc3)C3CC3)no2)cn1 CHEMBL3417525 IC50 1.7 nM
COCc1cc(Oc2c(C3CCC3)ccc(-c3cnc(N)cn3)c2F)nc(N)n1 CHEMBL3704296 Ki 1.7 nM
CCNS(=O)(=O)c1cc(C(F)(F)F)ccc1-c1ccc(-c2ncc(N)nc2C#N)c(F)c1 CHEMBL3697379 Ki 1.7 nM
COc1ccc(-c2ccc(Cn3c(CC(C)(C)C(=O)O)c(SC(C)(C)C)c4cc(OCc5cc(C)ccn5)ccc43)cc2)cn1 CHEMBL1922531 IC50 1.8 nM
Nc1ncc(-c2ccc(C3(c4noc(-c5ccc(NCC6(O)CC6)nc5)n4)CCC3)cn2)cn1 CHEMBL3684692 IC50 1.8 nM
CN1CCN(c2cnc(-c3nc(C4(c5ccc(-c6cnc(N)nc6)nc5)CCC4)no3)cn2)CC1 CHEMBL3684735 IC50 1.8 nM
Nc1ncc(-c2ccc(C3(c4noc(-c5ccc(N6CCNC(=O)C6)nc5)n4)CCC3)cn2)cn1 CHEMBL3689133 IC50 1.8 nM
Nc1cnc(-c2ccc(-c3cccnc3S(=O)(=O)C3CCC3)cc2F)cn1 CHEMBL3700841 Ki 1.8 nM
CC(C)(C)[C@@H](c1ccccc1)c1cc(OCc2ccc3ccccc3n2)ccc1-c1n[nH]c(=O)o1 CHEMBL2031659 IC50 1.9 nM
Cn1cc(-c2nc(C3(c4ccc(-c5cnc(N)nc5)cc4)CCC3)no2)cn1 CHEMBL3417429 IC50 1.9 nM
Nc1ncc(-c2ccc(C3(c4noc(-c5ccc(-n6ccnc6)nc5)n4)CCC3)cn2)cn1 CHEMBL3684705 IC50 1.9 nM
Nc1ncc(-c2ccc(C3(c4noc(-c5ccc(NCCO)nc5)n4)CCC3)cn2)cn1 CHEMBL3689123 IC50 1.9 nM
Cc1ccc(COc2ccc3nc(C4CCCC[C@@H]4C(=O)O)n(Cc4ccc(-c5ccc(C(F)(F)F)cc5)cc4)c3c2)nc1 CHEMBL3662265 Ki 1.9 nM
N#Cc1cccc(Oc2c(C3CCC3)ccc(-c3cnc(N)cn3)c2F)n1 CHEMBL3704266 Ki 1.9 nM
Nc1cnc(-c2ccc(-c3ccc(C(F)(F)F)cc3CN3CCOCC3)cc2F)cn1 CHEMBL3697286 Ki 1.9 nM
Nc1ccc(Oc2ccccc2-c2ccc(-c3cnc(N)cn3)c(F)c2)nc1 CHEMBL3697297 Ki 1.9 nM
N#Cc1nc(N)cnc1-c1ccc(-c2ccc(C(F)(F)F)cc2S(=O)(=O)NCCO)cc1F CHEMBL3697378 Ki 1.9 nM
Nc1ncc(-c2ccc(C3(c4noc(-c5cnn(C6COC6)c5)n4)CCC3)cc2)cn1 CHEMBL4071532 IC50 1.9 nM
CC(C)(C)Sc1c(CC(C)(C)C(=O)O)n(Cc2ccc(Cl)cc2)c2ccc(OCc3ccc4cnccc4n3)cc12 CHEMBL433133 IC50 2.0 nM
CC(C)(C)Sc1c(CC(C)(C)C(=O)O)n(Cc2ccc(Cl)cc2)c2ccc(OCc3nc4ccccc4s3)cc12 CHEMBL38545 IC50 2.0 nM
CC(C)(C)Sc1c(CC(C)(C)C(=O)O)n(Cc2ccc(Cl)cc2)c2ccc(OCc3ccc4cc(F)ccc4n3)cc12 CHEMBL78013 IC50 2.0 nM
CC(C)(C)Sc1c(CC(C)(C)C(=O)O)n(Cc2ccc(Cl)cc2)c2ccc(OCc3ccc4cccnc4n3)cc12 CHEMBL80726 IC50 2.0 nM
COc1cnc(-c2ccc(Cn3c(CC(C)(C)C(=O)[O-])c(SC(C)(C)C)c4cc(OCc5ccc(C)cn5)ccc43)cc2)nc1 CHEMBL1210423 IC50 2.0 nM
CC(C)C(C)(c1ccc(-c2cnc(N)nc2)cc1)c1noc(-c2cnn(C)c2)n1 CHEMBL3417517 IC50 2.0 nM
CCNc1ccc(-c2nc(C3(c4ccc(-c5cnc(N)nc5)nc4)CCC3)no2)cn1 CHEMBL3684682 IC50 2.0 nM
Nc1cnc(-c2ccc(C3CCC3)c(OCc3ccc(CC(=O)O)cc3)c2F)cn1 CHEMBL3704181 Ki 2.0 nM
Nc1cnc(-c2ccc(C3CCC3)c(Oc3cccc(C(F)(F)F)n3)c2F)cn1 CHEMBL3640031 Ki 2.0 nM
CC(C)CNS(=O)(=O)c1ccccc1-c1ccc(-c2cnc(N)cn2)c(F)c1 CHEMBL3688403 Ki 2.0 nM
CC1(NS(=O)(=O)c2ccccc2-c2ccc(-c3cnc(N)cn3)c(F)c2)CCC1 CHEMBL3688407 Ki 2.0 nM
CCC(C)(C)NS(=O)(=O)c1ccccc1-c1ccc(-c2cnc(N)cn2)c(F)c1 CHEMBL3688408 Ki 2.0 nM
Nc1cnc(-c2ccc(-c3ccccc3S(=O)(=O)NCCc3ccccc3)cc2F)cn1 CHEMBL3688413 Ki 2.0 nM
Nc1cnc(-c2ccc(-c3ccccc3S(=O)(=O)N[C@@H](c3ccccc3)C(F)(F)F)cc2F)cn1 CHEMBL3688414 Ki 2.0 nM
Nc1cnc(-c2ccc(-c3ccccc3S(=O)(=O)NC3Cc4ccccc4C3)cc2F)cn1 CHEMBL3688416 Ki 2.0 nM
C[C@@H](NS(=O)(=O)c1ccccc1-c1ccc(-c2cnc(N)cn2)c(F)c1)c1ccccc1 CHEMBL3700895 Ki 2.0 nM
Nc1cnc(-c2ccc(-c3ccccc3S(=O)(=O)N3CCCCC3)cc2F)cn1 CHEMBL3688434 Ki 2.0 nM
Nc1cnc(-c2ccc(-c3ccccc3S(=O)(=O)N3CCC(F)(F)CC3)cc2F)cn1 CHEMBL3688440 Ki 2.0 nM
[C-]#[N+]C1CCN(S(=O)(=O)c2ccccc2-c2ccc(-c3cnc(N)cn3)c(F)c2)CC1 CHEMBL3688454 Ki 2.0 nM
Nc1cnc(-c2ccc(-c3ccccc3S(=O)(=O)N3CCCC(O)C3)cc2F)cn1 CHEMBL3688460 Ki 2.0 nM
Nc1cnc(-c2ccc(-c3ccccc3S(=O)(=O)N3CCCC(CCO)C3)cc2F)cn1 CHEMBL3688461 Ki 2.0 nM
Nc1cnc(-c2ccc(-c3ccccc3S(=O)(=O)N3CCCC(CO)C3)cc2F)cn1 CHEMBL3688466 Ki 2.0 nM
Nc1cnc(-c2ccc(-c3ccccc3S(=O)(=O)N[C@@H]3CCCC[C@H]3O)cc2F)cn1 CHEMBL3688475 Ki 2.0 nM
Nc1cnc(-c2ccc(-c3ccccc3S(=O)(=O)NCC3(O)CCCCC3)cc2F)cn1 CHEMBL3688485 Ki 2.0 nM
CC(C)(O)CNS(=O)(=O)c1ccccc1-c1ccc(-c2cnc(N)cn2)c(F)c1 CHEMBL3688487 Ki 2.0 nM
Nc1cnc(-c2ccc(-c3ccccc3S(=O)(=O)NCCCCCO)cc2F)cn1 CHEMBL3688505 Ki 2.0 nM
CC(C)[C@@H](CO)NS(=O)(=O)c1ccccc1-c1ccc(-c2cnc(N)cn2)c(F)c1 CHEMBL3639873 Ki 2.0 nM
C[C@@H](CC#N)NS(=O)(=O)c1ccccc1-c1ccc(-c2cnc(N)cn2)c(F)c1 CHEMBL3688533 Ki 2.0 nM
N#CCCN1CCN(S(=O)(=O)c2ccccc2-c2ccc(-c3cnc(N)cn3)c(F)c2)CC1 CHEMBL3688536 Ki 2.0 nM
Nc1cnc(-c2ccc(-c3ccccc3S(=O)(=O)N3CCC(O)(c4ccccc4)C3)cc2F)cn1 CHEMBL3688539 Ki 2.0 nM
Nc1cnc(-c2ccc(-c3ccc(C(F)(F)F)cc3S(N)(=O)=O)cc2F)cn1 CHEMBL3688564 Ki 2.0 nM
Nc1cnc(-c2ccc(-c3ccccc3Sc3ncccn3)cc2F)cn1 CHEMBL3688569 Ki 2.0 nM
Nc1cnc(-c2ccc(-c3ccccc3Sc3cc(N)ncn3)cc2F)cn1 CHEMBL3688571 Ki 2.0 nM
Nc1cnc(-c2ccc(-c3ccccc3Sc3nccc(N)n3)cc2F)cn1 CHEMBL3688572 Ki 2.0 nM
Nc1cnc(-c2ccc(-c3ccccc3CSc3ccc(N)nn3)cc2F)cn1 CHEMBL3688596 Ki 2.0 nM
CC(C)CNS(=O)(=O)c1ccccc1-c1ccc(-c2cnc(N)nc2)c(F)c1 CHEMBL3693039 Ki 2.0 nM
CC(C)(C)NS(=O)(=O)c1ccccc1-c1ccc(-c2cnc(N)nc2)c(F)c1 CHEMBL3693050 Ki 2.0 nM
CCNS(=O)(=O)c1cc(C(F)(F)F)ccc1-c1ccc(-c2cnc(N)nc2)c(F)c1 CHEMBL3693071 Ki 2.0 nM
Nc1ncc(-c2ccc(-c3ccccc3Sc3ccnc(N)n3)cc2F)cn1 CHEMBL3693079 Ki 2.0 nM
CC(C)(C)NS(=O)(=O)c1ccccc1-c1ccc(-c2ccc(N)nc2)c(F)c1 CHEMBL3693086 Ki 2.0 nM
CC(C)(NS(=O)(=O)c1ccccc1-c1ccc(-c2ccc(N)nc2)c(F)c1)C(F)(F)F CHEMBL3693094 Ki 2.0 nM
CN(C)S(=O)(=O)c1ccccc1-c1ccc(-c2cnc3[nH]ccc3n2)c(F)c1 CHEMBL3693113 Ki 2.0 nM
O=S(=O)(c1ccccc1-c1ccc(-c2cnc3[nH]ccc3n2)c(F)c1)N1CCOCC1 CHEMBL3693118 Ki 2.0 nM
O=S(=O)(c1ccccc1-c1ccc(-c2cnc3c(c2)OCCN3)c(F)c1)N1CCCCC1 CHEMBL3693127 Ki 2.0 nM
C[C@@H](CO)NS(=O)(=O)c1ccccc1-c1ccc(-c2cnc3c(c2)OCCN3)c(F)c1 CHEMBL3693129 Ki 2.0 nM
CCN(CC)S(=O)(=O)c1ccccc1-c1ccc(-c2cnc3c(c2)OCCN3)c(F)c1 CHEMBL3693131 Ki 2.0 nM
CC(C)(C)NS(=O)(=O)c1ccccc1-c1ccc(-c2cnc3cc[nH]c3c2)c(F)c1 CHEMBL3693165 Ki 2.0 nM
CNS(=O)(=O)c1ccccc1-c1ccc(-c2cnc3[nH]ccc3c2)c(F)c1 CHEMBL3693166 Ki 2.0 nM
CC(C)(C)NS(=O)(=O)c1ccccc1-c1ccc(-c2cnc(N)c(Cl)c2)c(F)c1 CHEMBL3693190 Ki 2.0 nM
CC(C)(C)NS(=O)(=O)c1ccccc1-c1ccc(-c2cnc(N)cn2)c(F)c1F CHEMBL3693201 Ki 2.0 nM
Nc1cnc(-c2ccc(-c3ccccc3Oc3cc(N4CCC4)ncn3)cc2F)cn1 CHEMBL3697223 Ki 2.0 nM
COc1cnc(Oc2ccccc2-c2ccc(-c3cnc(N)nc3)c(F)c2)nc1 CHEMBL3697233 Ki 2.0 nM
Nc1cnc(-c2ccc(-c3ccc(C(F)(F)F)cc3O)cc2F)cn1 CHEMBL3697236 Ki 2.0 nM
Nc1cnc(-c2ccc(-c3ccc(C(F)(F)F)cc3Oc3ccnc(N)n3)cc2F)cn1 CHEMBL3697237 Ki 2.0 nM
Nc1ccnc(Oc2cc(C(F)(F)F)ccc2-c2ccc(-c3cnc(N)nc3)c(F)c2)n1 CHEMBL3697241 Ki 2.0 nM
CC(C)(C)NS(=O)(=O)c1ccccc1-c1ccc(-c2cnc(N)cn2)cc1 CHEMBL3697253 Ki 2.0 nM
N#Cc1nc(N)cnc1-c1ccc(-c2ccc(C(F)(F)F)cc2Oc2ncccn2)cc1F CHEMBL3700787 Ki 2.0 nM
Cc1cc(-c2ccc(C(=O)[C@@H]3CCCC[C@H]3C(=O)Nc3cnn4c3C(=O)NCC4)cc2)n[nH]1 CHEMBL4542281 fIC50 2.0 nM
CC(C)(C)Sc1c(CC(C)(C)C(=O)O)n(Cc2ccc(-c3ncc(F)s3)cc2)c2ccc(OCc3ccccn3)cc12 CHEMBL552545 IC50 2.1 nM
COc1ccc(-c2ccc(Cn3c(CC(C)(C)C(=O)O)c(SC(C)(C)C)c4cc(OCc5ccc6ccc(F)cc6n5)ccc43)cc2)cn1 CHEMBL1922526 IC50 2.1 nM
COC(=O)c1ccc(OCc2ccc3ccccc3n2)cc1[C@]1(c2ccccc2)C[C@H]2CC[C@H]1C2 CHEMBL2029369 IC50 2.1 nM
CC(C)(O)Cn1cc(-c2nc([C@@](C)(c3ccc(-c4cnc(N)nc4)cc3)C3CC3)no2)cn1 CHEMBL3417531 IC50 2.1 nM
CC(C)(O)CNc1ccc(-c2nc(C3(c4ccc(-c5cnc(N)nc5)nc4)CCC3)no2)cn1 CHEMBL3684686 IC50 2.1 nM
COc1cnc(-c2ccc(Cn3c(CC(C)(C)C(=O)O)c(SC(C)(C)C)c4cc(OC[C@@H]5Cc6ccccc6N5C(C)=O)ccc43)cc2)nc1 CHEMBL595092 IC50 2.2 nM
CC(C)c1ccc2c(c1)c(SC(C)(C)C)c(CC(C)(C)C(=O)O)n2Cc1ccc(Cl)cc1 CHEMBL29097 IC50 2.2 nM
Nc1nnc(-c2ccc(OCc3ccc4ccccc4n3)cc2[C@]2(c3ccccc3)C[C@H]3CC[C@H]2C3)o1 CHEMBL2031645 IC50 2.2 nM
Nc1ncc(-c2ccc(C3(c4noc(-c5cccnc5)n4)CCC3)cc2)cn1 CHEMBL3417415 IC50 2.2 nM
Nc1ncc(-c2ccc(C3(c4noc(-c5ccc(NC(CO)CO)nc5)n4)CCC3)cn2)cn1 CHEMBL3684707 IC50 2.2 nM
Nc1ncc(-c2ccc(C3(c4noc(-c5ccc(N6CC[C@H](O)C6)nc5)n4)CCC3)cn2)cn1 CHEMBL3684722 IC50 2.2 nM
CC(C)(C)n1c(-c2ccccc2C(=O)Nc2ccccn2)nc2cc(-c3cnc(N)nc3)ccc21 CHEMBL3681348 IC50 2.2 nM
Cc1ccc(COc2ccc3nc([C@@H]4CCCC[C@H]4C(=O)O)n(Cc4ccc(Br)cc4)c3c2)nc1 CHEMBL3667016 Ki 2.2 nM
Cn1ccc(COc2ccc3nc(C4CCCC[C@@H]4C(=O)O)n(Cc4ccc(OC(F)(F)F)cc4)c3c2)n1 CHEMBL3662266 Ki 2.2 nM
Cc1ccc(COc2ccc3nc([C@@H]4CCCC[C@@H]4C(=O)O)n(Cc4ccc(N5CC(F)(F)C5)cc4F)c3c2)nc1 CHEMBL3666993 Ki 2.2 nM
O=C(O)Cc1ccc(COc2c(C3CCC3)ccc(-c3cnc4c(c3)OCCN4)c2F)cc1 CHEMBL3704351 Ki 2.2 nM
Cc1cc(Oc2c(C3CCC3)ccc(-c3cnc(N)cn3)c2F)nc(N(C)C)n1 CHEMBL3659267 Ki 2.2 nM
Cc1ccc(COc2ccc3nc([C@H]4CCCC[C@H]4C(=O)O)n(Cc4ccc(N5CC(F)(F)C5)cc4F)c3c2)nc1 CHEMBL3666992 Ki 2.2 nM
COC(=O)c1ccc(OCc2ccc3ccccc3n2)cc1[C@]1(c2cccc(F)c2)C[C@H]2CC[C@H]1C2 CHEMBL2031437 IC50 2.3 nM
Nc1ncc(-c2ccc(C3(c4noc(-c5cn[nH]c5)n4)CCC3)cc2)cn1 CHEMBL3417428 IC50 2.3 nM
Nc1cnc(-c2ccc(C3CCC3)c(Oc3ccc(C(=O)O)cc3)c2F)cn1 CHEMBL3704307 Ki 2.3 nM
O=C(Nc1cccnc1)Oc1ccc(OCc2ccc3ccccc3n2)cc1C1(c2ccccc2)CCCC1 CHEMBL404276 IC50 2.4 nM
O=C(Nc1cccnc1)Oc1ccc(OCc2nc3ccccc3s2)cc1C1(c2ccccc2)CC2CCC1C2 CHEMBL541915 IC50 2.4 nM
COc1ccc(-c2ccc(Cn3c(CC(C)(C)C(=O)O)c(SC(C)(C)C)c4cc(OCc5cc(C)on5)ccc43)cc2)cn1 CHEMBL1922650 IC50 2.4 nM
CCn1nnc(-c2ccc(OCc3ccc4ccccc4n3)cc2[C@]2(c3ccccc3)C[C@H]3CC[C@H]2C3)n1 CHEMBL2031654 IC50 2.4 nM
FC(F)n1nnc(-c2ccc(OCc3ccc4ccccc4n3)cc2[C@]2(c3ccccc3)C[C@H]3CC[C@H]2C3)n1 CHEMBL2031656 IC50 2.4 nM
COCCn1cc(-c2nc(C3(c4ccc(-c5cnc(N)nc5)cc4)CCC3)no2)cn1 CHEMBL3417431 IC50 2.4 nM
Nc1ncc(-c2ccc(C3(c4noc(-c5cc[nH]n5)n4)CCC3)cc2)cn1 CHEMBL3417427 IC50 2.4 nM
Nc1ncc(-c2ccc(C3(c4noc(-c5cscn5)n4)CCC3)cc2)cn1 CHEMBL3417425 IC50 2.4 nM
C[C@H](O)CNc1ccc(-c2nc(C3(c4ccc(-c5cnc(N)nc5)nc4)CCC3)no2)cn1 CHEMBL3684720 IC50 2.4 nM
CCNc1cnc(-c2nc(C3(c4ccc(-c5cnc(N)nc5)nc4)CCC3)no2)cn1 CHEMBL3684731 IC50 2.4 nM
CN(C)c1ccc(-c2nc(C3(c4ccc(-c5cnc(N)nc5)nc4)CCC3)no2)cn1 CHEMBL3689118 IC50 2.4 nM
CNc1ccc(-c2nc(C3(c4ccc(-c5cnc(N)nc5)nc4)CCC3)no2)cn1 CHEMBL3689121 IC50 2.4 nM
Cn1ccc(COc2cc(F)c3nc([C@@H]4CCCC[C@@H]4C(=O)O)n(Cc4ccc(Br)cc4F)c3c2)n1 CHEMBL3666925 Ki 2.4 nM
Cc1ccc(COc2ccc3nc(C4CCCC[C@@H]4C(=O)O)n(Cc4ccc(N5CCC(F)(F)C5)cc4)c3c2)nc1 CHEMBL3944626 Ki 2.4 nM
N#Cc1cccnc1Oc1c(C2CCC2)ccc(-c2cnc(N)cn2)c1F CHEMBL3704265 Ki 2.4 nM
Nc1cnc(-c2ccc(C3CCC3)c(Oc3ncc(-c4cnc(N)nc4)cn3)c2F)cn1 CHEMBL3659340 Ki 2.4 nM
CCNS(=O)(=O)c1cc(C(F)(F)F)ccc1-c1cnc(-c2cnc(N)nc2)c(F)c1 CHEMBL3697341 Ki 2.4 nM
CC(C)(CO)CNS(=O)(=O)c1ccccc1-c1ccc(-c2ncc(N)nc2C#N)c(F)c1 CHEMBL3697380 Ki 2.4 nM
Cn1ccc(COc2cc(F)c3nc([C@H]4CCCC[C@H]4C(=O)O)n(Cc4ccc(Br)cc4F)c3c2)n1 CHEMBL3921259 Ki 2.4 nM
Cc1ccc(COc2ccc3nc(C4CCCC[C@H]4C(=O)O)n(Cc4ccc(N5CCC(F)(F)C5)cc4)c3c2)nc1 CHEMBL3666978 Ki 2.4 nM
Cc1cc(-c2nc(C3(c4ccc(-c5cnc(N)nc5)cc4)CCC3)no2)[nH]n1 CHEMBL4094923 IC50 2.4 nM
C1=CC(COc2ccc(OCc3ccc4ccccc4n3)cc2C2(c3ccccc3)CCCC2)=CNC1 CHEMBL255227 IC50 2.5 nM
O=C(Nc1cccnc1)Oc1ccc(OCc2nc3ccccc3s2)cc1C1(c2ccccc2)CC2CCC1C2 CHEMBL558778 IC50 2.5 nM
COc1nc(-c2ccc(Cn3c(CC(C)(C)C(=O)O)c(SC(C)(C)C)c4cc(OC[C@@H]5Cc6ccccc6N5C(C)=O)ccc43)cc2)cs1 CHEMBL610472 IC50 2.5 nM
COC(=O)c1ccc(OCc2ccc3ccccc3n2)cc1[C@]1(c2cccc(OC)c2)C[C@H]2CC[C@H]1C2 CHEMBL2031441 IC50 2.5 nM
O=c1[nH]nc(-c2ccc(OCc3ccc4ccccc4n3)cc2[C@]2(c3ccccc3)C[C@H]3CC[C@H]2C3)o1 CHEMBL2031646 IC50 2.5 nM
Nc1ncc(-c2ccc(C3(c4noc(-c5c[nH]cn5)n4)CCC3)cc2)cn1 CHEMBL3417422 IC50 2.5 nM
Nc1ncc(-c2ccc(C3(c4noc(-c5ccc(OCCO)nc5)n4)CCC3)cn2)cn1 CHEMBL3684696 IC50 2.5 nM
Cc1ccc(COc2ccc3nc(C4CCCC[C@H]4C(=O)O)n(Cc4ccc(Br)c(F)c4)c3c2)nc1 CHEMBL3662240 Ki 2.5 nM
Cc1ccc(COc2ccc3nc([C@H]4CCCC[C@H]4C(=O)O)n(Cc4c(F)cc(-c5ccc(C(F)(F)F)cc5)cc4F)c3c2)nc1 CHEMBL3666966 Ki 2.5 nM
Fc1c(-c2cnc3c(c2)OCCN3)ccc(C2CCC2)c1Oc1ncccn1 CHEMBL3659256 Ki 2.5 nM
Fc1c(-c2cnc3[nH]ccc3n2)ccc(C2CCC2)c1Oc1ncccn1 CHEMBL3659261 Ki 2.5 nM
Cc1ccc(COc2ccc3nc(C4CCCC[C@@H]4C(=O)O)n(Cc4ccc(Br)c(F)c4)c3c2)nc1 CHEMBL3967529 Ki 2.5 nM
CC1CC(c2ccccc2)(c2cc(OCc3ccc4ccccc4n3)ccc2-c2n[nH]c(=O)o2)C1 CHEMBL2031661 IC50 2.6 nM
Cn1cc(-c2nc([C@@](C)(c3ccc(-c4cnc(N)nc4)cc3)C3CCC3)no2)cn1 CHEMBL3417522 IC50 2.6 nM
NCCn1cc(-c2nc(C3(c4ccc(-c5cnc(N)nc5)cc4)CCC3)no2)cn1 CHEMBL3417508 IC50 2.6 nM
CC(C)(CO)Nc1ccc(-c2nc(C3(c4ccc(-c5cnc(N)nc5)nc4)CCC3)no2)cn1 CHEMBL3684695 IC50 2.6 nM
CS(=O)(=O)C1CCN(c2ccc(-c3nc(C4(c5ccc(-c6cnc(N)nc6)nc5)CCC4)no3)cn2)C1 CHEMBL3684726 IC50 2.6 nM
Nc1ncc(-c2ccc(C3(c4noc(-c5ccc(N6CCN(CCC(=O)O)CC6)nc5)n4)CCC3)cn2)cn1 CHEMBL3684727 IC50 2.6 nM
Nc1ncc(-c2ccc(C3(c4noc(-c5ccc(N6CCNCC6)cc5)n4)CCC3)cn2)cn1 CHEMBL3684736 IC50 2.6 nM
Cc1ccc(COc2ccc3nc([C@H]4CCCC[C@H]4C(=O)O)n(Cc4ccc(OC(F)(F)F)c(C)c4)c3c2)nc1 CHEMBL3957866 Ki 2.6 nM
CC(C)(CO)NS(=O)(=O)c1ccccc1-c1ccc(-c2ccc(N)nc2)c(F)c1 CHEMBL3697332 Ki 2.6 nM
Cc1ccc(COc2ccc3nc([C@@H]4CCCC[C@@H]4C(=O)O)n(Cc4ccc(OC(F)(F)F)c(C)c4)c3c2)nc1 CHEMBL3666939 Ki 2.6 nM
Nc1ncc(-c2ccc(C3(c4noc(-c5ccc(N6CCNCC6)nc5)n4)CCC3)cn2)cn1 CHEMBL3684677 IC50 2.7 nM
C[C@@H](O)CNc1ccc(-c2nc(C3(c4ccc(-c5cnc(N)nc5)nc4)CCC3)no2)cn1 CHEMBL3684718 IC50 2.7 nM
CS(=O)(=O)N1CCN(c2ccc(-c3nc(C4(c5ccc(-c6cnc(N)nc6)nc5)CCC4)no3)cn2)CC1 CHEMBL3684724 IC50 2.7 nM
Nc1ncc(-c2ccc(C3(c4noc(-c5ccc(N6CCOCC6)nc5)n4)CCC3)cn2)cn1 CHEMBL3689098 IC50 2.7 nM
CC1(C)[C@H](c2nc3cc(OCc4ccc5ccccc5n4)ccc3n2Cc2ccc(Br)cc2F)[C@@H]1C(=O)O CHEMBL3678318 Ki 2.7 nM
Cc1c(CC(C)(C)C(=O)O)n(Cc2ccc(Cl)cc2)c2ccc(OCc3ccc4ccccc4n3)cc12 CHEMBL31540 IC50 2.8 nM
O=C(Nc1cccnc1)Oc1ccc(OCc2nc3ccccc3s2)cc1C1(c2ccccc2)CC2CCC1C2 CHEMBL401667 IC50 2.8 nM
Cn1nnc(-c2ccc(OCc3ccc4ccccc4n3)cc2[C@]2(c3ccccc3)C[C@H]3CC[C@H]2C3)n1 CHEMBL2031653 IC50 2.8 nM
COCCNc1ccc(-c2nc(C3(c4ccc(-c5cnc(N)nc5)nc4)CCC3)no2)cn1 CHEMBL3689126 IC50 2.8 nM
CC(C)c1cc(Oc2c(C3CCC3)ccc(-c3cnc(N)nc3)c2F)nc(N)n1 CHEMBL3704323 Ki 2.8 nM
CCC(C)S(=O)(=O)c1ncccc1-c1ccc(-c2cnc(N)cn2)c(F)c1 CHEMBL3700849 Ki 2.8 nM
c1ccc([C@@]2(c3cc(OCc4ccc5ccccc5n4)ccc3-c3nnco3)C[C@H]3CC[C@H]2C3)cc1 CHEMBL2031649 IC50 2.9 nM
c1ccc([C@@]2(c3cc(OCc4ccc5ccccc5n4)ccc3-c3nn[nH]n3)C[C@H]3CC[C@H]2C3)cc1 CHEMBL2031652 IC50 2.9 nM
CNc1ncc(-c2ccc([C@](C)(c3noc(-c4cnn(CC(=O)N(C)C)c4)n3)C3CC3)cc2)cn1 CHEMBL3417527 IC50 2.9 nM
Nc1ncc(-c2ccc(C3(c4noc(-c5ccc[nH]c5=O)n4)CCC3)cc2)cn1 CHEMBL3417421 IC50 2.9 nM
Nc1ncc(-c2ccc(C3(c4noc(-c5ccc(NC6CC6)nc5)n4)CCC3)cn2)cn1 CHEMBL3684683 IC50 2.9 nM
Nc1ncc(-c2ccc(C3(c4noc(-c5ccc(O)cc5)n4)CCC3)cn2)cn1 CHEMBL3684706 IC50 2.9 nM
Cc1ccc(COc2cc(F)c3nc([C@H]4CCCC[C@H]4C(=O)O)n(Cc4ccc(Br)cc4)c3c2)nc1 CHEMBL3915265 Ki 2.9 nM
Cn1cc(Cl)c(COc2ccc3nc([C@@H]4CCCC[C@@H]4C(=O)O)n(Cc4ccc(Br)cc4)c3c2)n1 CHEMBL3666912 Ki 2.9 nM
Cc1cnc(COc2ccc3nc([C@@H]4[C@H](C(=O)O)C4(C)C)n(Cc4ccc(Br)cc4)c3c2)c(F)c1 CHEMBL3666960 Ki 2.9 nM
Nc1cnc(-c2ccc(C3CCC3)c(Oc3cc(Cl)nc(N)n3)c2F)cn1 CHEMBL3704297 Ki 2.9 nM
Fc1c(-c2cnc3c(c2)OCCN3)ccc(C2CCC2)c1Oc1cccc(C(F)(F)F)n1 CHEMBL3704350 Ki 2.9 nM
Nc1cnc(-c2ccc(-c3ccccc3Sc3cncc(N)n3)cc2F)cn1 CHEMBL3700783 Ki 2.9 nM
Nc1cnc(-c2ccc(-c3cccnc3S(=O)(=O)C3CCOCC3)cc2F)cn1 CHEMBL3700865 Ki 2.9 nM
Cc1ccc(COc2cc(F)c3nc([C@@H]4CCCC[C@@H]4C(=O)O)n(Cc4ccc(Br)cc4)c3c2)nc1 CHEMBL3662283 Ki 2.9 nM
Cn1cc(Cl)c(COc2ccc3nc([C@H]4CCCC[C@H]4C(=O)O)n(Cc4ccc(Br)cc4)c3c2)n1 CHEMBL3975988 Ki 2.9 nM
CN(C)C(=O)Cn1cc(-c2nc([C@@](C)(c3ccc(-c4cnc(N)nc4)nc3)C3CC3)no2)cn1 CHEMBL4072041 IC50 2.9 nM
Cc1nc(COc2ccc3c(c2)c(SC(C)(C)C)c(CC(C)(C)C(=O)O)n3Cc2ccc(Cl)cc2)cs1 CHEMBL82760 IC50 3.0 nM
COC(=O)c1ccc(OCc2ccc3ccccc3n2)cc1C(CC(C)(C)C)c1ccccc1 CHEMBL2031448 IC50 3.0 nM
COCCN(C)c1ccc(-c2nc(C3(c4ccc(-c5cnc(N)nc5)nc4)CCC3)no2)cn1 CHEMBL3689125 IC50 3.0 nM
Cn1ccc(COc2ccc3nc([C@H]4CCCC[C@H]4C(=O)O)n(Cc4ccc(OC(F)(F)F)cc4F)c3c2)n1 CHEMBL3662278 Ki 3.0 nM
Cc1ccc(COc2ccc3nc([C@H]4CCCC[C@@H]4C(=O)O)n(Cc4c(F)cc(Br)cc4F)c3c2)nc1 CHEMBL3666968 Ki 3.0 nM
Cc1ccc(COc2ccc3nc([C@H]4CCCC[C@H]4C(=O)O)n(Cc4ccc(N5CCCCC5)cc4)c3c2)nc1 CHEMBL3666984 Ki 3.0 nM
CCC(CC)(Cc1nc2ccc(OCc3ncc(C)cc3F)cc2n1Cc1ccc(N2CCC(C)CC2)cc1)C(=O)O CHEMBL3667005 Ki 3.0 nM
CC1(C)CCCC1(Cc1nc2cc(OCc3ccc4ccccc4n3)ccc2n1Cc1ccc(Br)cc1)C(=O)O CHEMBL3678312 Ki 3.0 nM
COc1ccnc(Oc2c(C3CCC3)ccc(-c3cnc(N)cn3)c2F)n1 CHEMBL3704249 Ki 3.0 nM
Nc1cnc(-c2ccc(C3CCC3)c(Oc3ccnc(C(F)(F)F)n3)c2F)cn1 CHEMBL3704278 Ki 3.0 nM
Nc1cnc(-c2ccc(-c3ccccc3S(=O)(=O)NCC3CCC3)cc2F)cn1 CHEMBL3688405 Ki 3.0 nM
Nc1cnc(-c2ccc(-c3ccccc3S(=O)(=O)NC3CC4CCC3C4)cc2F)cn1 CHEMBL3688406 Ki 3.0 nM
Nc1cnc(-c2ccc(-c3ccccc3S(=O)(=O)NC3CCCC3)cc2F)cn1 CHEMBL3688410 Ki 3.0 nM
C[C@H](CO)NS(=O)(=O)c1ccccc1-c1ccc(-c2cnc(N)cn2)c(F)c1 CHEMBL3688423 Ki 3.0 nM
Nc1cnc(-c2ccc(-c3ccccc3S(=O)(=O)N3CCS(=O)(=O)CC3)cc2F)cn1 CHEMBL3688436 Ki 3.0 nM
Nc1cnc(-c2ccc(-c3ccccc3S(=O)(=O)N3CCCCCC3)cc2F)cn1 CHEMBL3688444 Ki 3.0 nM
Nc1cnc(-c2ccc(-c3ccccc3S(=O)(=O)N3CCC(O)CC3)cc2F)cn1 CHEMBL3688457 Ki 3.0 nM
CC(C)(C)OC(=O)NC1CCCN(S(=O)(=O)c2ccccc2-c2ccc(-c3cnc(N)cn3)c(F)c2)C1 CHEMBL3688467 Ki 3.0 nM
CC[C@H](C)[C@@H](CO)NS(=O)(=O)c1ccccc1-c1ccc(-c2cnc(N)cn2)c(F)c1 CHEMBL3688474 Ki 3.0 nM
CC[C@H](CO)NS(=O)(=O)c1ccccc1-c1ccc(-c2cnc(N)cn2)c(F)c1 CHEMBL3688476 Ki 3.0 nM
Nc1cnc(-c2ccc(-c3ccccc3S(=O)(=O)N[C@@H]3CCCC[C@@H]3O)cc2F)cn1 CHEMBL3688477 Ki 3.0 nM
Nc1cnc(-c2ccc(-c3ccccc3S(=O)(=O)N[C@H]3CC[C@H](O)CC3)cc2F)cn1 CHEMBL3688492 Ki 3.0 nM
Nc1cnc(-c2ccc(-c3ccccc3S(=O)(=O)N3CC(O)C3)cc2F)cn1 CHEMBL3688496 Ki 3.0 nM
Nc1cnc(-c2ccc(-c3ccccc3S(=O)(=O)N3CCC[C@H](N)C3)cc2F)cn1 CHEMBL3688509 Ki 3.0 nM
CC[C@@H](CO)NS(=O)(=O)c1ccccc1-c1ccc(-c2cnc(N)cn2)c(F)c1 CHEMBL3688520 Ki 3.0 nM
N#CCCNS(=O)(=O)c1ccccc1-c1ccc(-c2cnc(N)cn2)c(F)c1 CHEMBL3688532 Ki 3.0 nM
Nc1cnc(-c2ccc(-c3ccccc3S(=O)(=O)C3CCCC3)cc2F)cn1 CHEMBL3688553 Ki 3.0 nM
Nc1cnc(-c2ccc(-c3ccccc3Sc3cnccn3)cc2F)cn1 CHEMBL3688574 Ki 3.0 nM
Nc1cnc(-c2ccc(-c3ccccc3CSc3ccncn3)cc2F)cn1 CHEMBL3688599 Ki 3.0 nM
CC(C)(CO)NS(=O)(=O)c1ccccc1-c1ccc(-c2cnc(N)nc2)c(F)c1 CHEMBL3693027 Ki 3.0 nM
Nc1ncc(-c2ccc(-c3ccccc3S(=O)(=O)Nc3ccccc3)cc2F)cn1 CHEMBL3693032 Ki 3.0 nM
Nc1ncc(-c2ccc(-c3ccc(C(F)(F)F)cc3S(=O)(=O)NCCO)cc2F)cn1 CHEMBL3639919 Ki 3.0 nM
O=C1NCC[C@@H]1NS(=O)(=O)c1ccccc1-c1ccc(-c2cnc3[nH]ccc3c2)c(F)c1 CHEMBL3693107 Ki 3.0 nM
O=S(=O)(c1ccccc1-c1ccc(-c2cnc3[nH]ccc3c2)c(F)c1)C1CC1 CHEMBL3693108 Ki 3.0 nM
CC(C)(C)NS(=O)(=O)c1ccccc1-c1ccc(-c2ccc3[nH]cnc3c2)c(F)c1 CHEMBL3693162 Ki 3.0 nM
CC(C)(C)NS(=O)(=O)c1ccccc1-c1ccc(-c2cnc3[nH]cnc3n2)c(F)c1 CHEMBL3693186 Ki 3.0 nM
Nc1cc(-c2ccc(-c3ccccc3S(=O)(=O)NC3(CO)CCCC3)cc2F)cc2cc[nH]c12 CHEMBL3693195 Ki 3.0 nM
CNS(=O)(=O)c1ccccc1-c1ccc(-c2cnc3[nH]cc(CO)c3c2)c(F)c1 CHEMBL3693196 Ki 3.0 nM
Fc1cc(-c2ccccc2Oc2ncccn2)ccc1-c1cnc2[nH]ccc2c1 CHEMBL3697209 Ki 3.0 nM
N#Cc1cc(Oc2ccccc2-c2ccc(-c3cnc(N)cn3)c(F)c2)ccn1 CHEMBL3697221 Ki 3.0 nM
Cc1ccc(COc2ccc3nc([C@@H]4CCCC[C@@H]4C(=O)O)n(Cc4ccc(N5CCCCC5)cc4)c3c2)nc1 CHEMBL3666983 Ki 3.0 nM
Cn1cc(-c2nc([C@@](C)(c3ccc(-c4cnc(N)nc4)nc3)C3CC3)no2)cn1 CHEMBL4080469 IC50 3.0 nM
CN(C)CCn1cc(-c2nc([C@@](C)(c3ccc(-c4cnc(N)nc4)cc3)C3CC3)no2)cn1 CHEMBL3417530 IC50 3.1 nM
Nc1ncc(-c2ccc(C3(c4noc(-c5ccc(N6CCC[C@@H]6CO)nc5)n4)CCC3)cn2)cn1 CHEMBL3684719 IC50 3.1 nM
CC(C)[C@](C)(c1ccc(-c2cnc(N)nc2)cc1)c1noc(N2CCC(C)(O)CC2)n1 CHEMBL4080822 IC50 3.1 nM
COC1=CC=C(c2ccc(Cn3c(CC(C)(C)C(=O)O)c(SC(C)(C)C)c4cc(OC[C@@H]5Cc6ccccc6N5C(C)=O)ccc43)cc2)NN1 CHEMBL594773 IC50 3.2 nM
COC(=O)c1ccc(OCc2ccc3ccccc3n2)cc1C1(c2ccccc2)CC(C)C1 CHEMBL2031453 IC50 3.2 nM
COC(=O)[C@H]1CNCCN1c1ccc(-c2nc(C3(c4ccc(-c5cnc(N)nc5)nc4)CCC3)no2)cn1 CHEMBL3684712 IC50 3.2 nM
COCCNc1cnc(-c2nc(C3(c4ccc(-c5cnc(N)nc5)nc4)CCC3)no2)cn1 CHEMBL3684730 IC50 3.2 nM
CC(C)(C)n1c(-c2cc(Cl)cnc2-n2cncn2)nc2cc(-c3cnc(N)nc3)ccc21 CHEMBL3641489 IC50 3.2 nM
C[C@@H]([C@@H](O)c1ccccc1)N(C)S(=O)(=O)c1ccccc1-c1ccc(-c2ccc(N)nc2)c(F)c1 CHEMBL3697333 Ki 3.2 nM
Nc1cnc(-c2ccc(-c3cccnc3S(=O)(=O)C3CC3)cc2F)cn1 CHEMBL3700864 Ki 3.2 nM
COc1nc(-c2ccc(Cn3c(CC(C)(C)C(=O)O)c(SC(C)(C)C)c4cc(OCc5ccccn5)ccc43)cc2)cs1 CHEMBL557548 IC50 3.3 nM
COc1ccc(-c2ccc(Cn3c(CC(C)(C)C(=O)O)c(SC(C)(C)C)c4cc(OCc5cnc(C)cn5)ccc43)cc2)cn1 CHEMBL1922649 IC50 3.3 nM
COC(=O)[C@H]1CN(c2ccc(-c3nc(C4(c5ccc(-c6cnc(N)nc6)nc5)CCC4)no3)cn2)CCN1 CHEMBL3684714 IC50 3.3 nM
Nc1ncc(-c2ccc(C3(c4noc(-c5ccc(N6CCCC6)nc5)n4)CCC3)cn2)cn1 CHEMBL3689120 IC50 3.3 nM
Cc1ccc(COc2ccc3nc(C4CCCCC4)n(Cc4ccc(-c5ncc(Cl)cn5)cc4)c3c2)nc1 CHEMBL3666911 Ki 3.3 nM
Cc1nc(Oc2c(C3CCC3)ccc(-c3cnc(N)cn3)c2F)cc(N(C)C)n1 CHEMBL3659266 Ki 3.3 nM
CN(C)c1cc(Oc2c(C3CCC3)ccc(-c3cnc(N)cn3)c2F)ncn1 CHEMBL3659268 Ki 3.3 nM
Nc1cnc(-c2ccc(-c3cccnc3S(=O)(=O)C3CCS(=O)(=O)CC3)cc2F)cn1 CHEMBL3700855 Ki 3.3 nM
COC(=O)c1ccc(OCc2ccc3ccccc3n2)cc1[C@]1(c2cc(F)cc(F)c2)C[C@H]2CC[C@H]1C2 CHEMBL2031442 IC50 3.4 nM
CCOC(=O)CCN1CCN(c2ccc(-c3nc(C4(c5ccc(-c6cnc(N)nc6)nc5)CCC4)no3)cn2)CC1 CHEMBL3684721 IC50 3.4 nM
N#Cc1cccc(Oc2ccccc2-c2ccc(-c3cnc(N)cn3)c(F)c2)n1 CHEMBL3697296 Ki 3.4 nM
O=C(O)CCCOc1ccc(OCc2ccc3ccccc3n2)cc1C1(c2ccccc2)CC2CCC1C2 CHEMBL256975 IC50 3.5 nM
COC(=O)c1ccc(OCc2ccc3ccccc3n2)cc1[C@]1(c2cc(C)cc(C)c2)C[C@H]2CC[C@H]1C2 CHEMBL2031443 IC50 3.5 nM
CC(C)(O)Cn1cc(-c2nc(C3(c4ccc(-c5cnc(N)nc5)cc4)CCC3)no2)cn1 CHEMBL3417511 IC50 3.5 nM
O=C(O)[C@@H]1CCCC[C@@H]1c1nc2cc(OCc3nc4ccccc4s3)ccc2n1Cc1ccc(Br)cc1 CHEMBL3683273 Ki 3.5 nM
Nc1cnc(-c2ccc(C3CCC3)c(Oc3cc(N)ncn3)c2F)cn1 CHEMBL3704290 Ki 3.5 nM
CC1(C)CC(c2ccccc2)(c2cc(OCc3ccc4ccccc4n3)ccc2-c2n[nH]c(=O)o2)C1 CHEMBL2031660 IC50 3.6 nM
CN(C)C(=O)Cn1cc(-c2nc(C3(c4ccc(-c5cnc(N)nc5)cc4)CCC3)no2)cn1 CHEMBL3417510 IC50 3.6 nM
CN(C)CCn1cc(-c2nc(C3(c4ccc(-c5cnc(N)nc5)cc4)CCC3)no2)cn1 CHEMBL3417509 IC50 3.6 nM
Cn1ccc(COc2cc(F)c3nc([C@H]4CCCC[C@H]4C(=O)O)n(Cc4ccc(OC(F)(F)F)cc4)c3c2)n1 CHEMBL3949092 Ki 3.6 nM
O=C(O)[C@H]1CCCCC1c1nc2cc(OCc3ccc4ccccc4n3)ccc2n1Cc1ccc(Br)cc1 CHEMBL3678307 Ki 3.6 nM
CC(C)Cc1cc(Oc2c(C3CCC3)ccc(-c3cnc(N)cn3)c2F)nc(N)n1 CHEMBL3659273 Ki 3.6 nM
Cn1ccc(COc2cc(F)c3nc([C@@H]4CCCC[C@@H]4C(=O)O)n(Cc4ccc(OC(F)(F)F)cc4)c3c2)n1 CHEMBL3666926 Ki 3.6 nM
COC(=O)COc1ccc(OCc2ccc3ccccc3n2)cc1C1(c2ccccc2)CCCCC1 CHEMBL255228 IC50 3.7 nM
CCOC(=O)CCCOc1ccc(OCc2ccc3ccccc3n2)cc1C1(c2ccccc2)CC2CCC1C2 CHEMBL403199 IC50 3.7 nM
COC(=O)[C@@H]1CN(c2ccc(-c3nc(C4(c5ccc(-c6cnc(N)nc6)nc5)CCC4)no3)cn2)CCN1 CHEMBL3684713 IC50 3.7 nM
Nc1ncc(-c2ccc(C3(c4noc(-c5ccc(N6CCS(=O)(=O)CC6)nc5)n4)CCC3)cn2)cn1 CHEMBL3684723 IC50 3.7 nM
Cc1ccc(COc2ccc3nc(C4CCCC[C@@H]4C(=O)O)n(Cc4ccc(N5CCC(F)(F)CC5)cc4)c3c2)nc1 CHEMBL3931434 Ki 3.7 nM
Nc1cnc(-c2ccc(C3CCC3)c(Oc3ccnc(N)n3)c2F)cn1 CHEMBL3704284 Ki 3.7 nM
Nc1cnc(-c2ccc(C3CCC3)c(Oc3ccnc(Cl)n3)c2F)cn1 CHEMBL3704291 Ki 3.7 nM
O=CNc1ccc(COc2c(C3CCC3)ccc(-c3cnc4c(c3)OCCN4)c2F)cc1 CHEMBL3704349 Ki 3.7 nM
Cc1csc2ncnc(Oc3c(C4CCC4)ccc(-c4cnc(N)cn4)c3F)c12 CHEMBL3659358 Ki 3.7 nM
Cc1ccc(COc2ccc3nc(C4CCCC[C@H]4C(=O)O)n(Cc4ccc(N5CCC(F)(F)CC5)cc4)c3c2)nc1 CHEMBL3666980 Ki 3.7 nM
CC(C)(C)NC(=O)Cn1cc(-c2nc(C3(c4ccc(-c5cnc(N)nc5)cc4)CCC3)no2)cn1 CHEMBL4092404 IC50 3.7 nM
COc1ccc(-c2ccc(Cn3c(CC(C)(C)C(=O)O)c(SC(C)(C)C)c4cc(OC[C@@H]5Cc6ccccc6N5C(C)=O)ccc43)cc2)nc1 CHEMBL610474 IC50 3.8 nM
CC(C)(C)CC(=O)N1CCN(c2ccc(-c3nc(C4(c5ccc(-c6cnc(N)nc6)nc5)CCC4)no3)cn2)CC1 CHEMBL3689181 IC50 3.8 nM
Cc1ccc(COc2ccc3nc([C@H]4CCCC[C@H]4C(=O)O)n(Cc4ccc(N5CC(F)(F)C5)cc4)c3c2)nc1 CHEMBL3908465 Ki 3.8 nM
Nc1cnc(-c2ccc(C3CCC3)c(Oc3nccnc3N)c2F)cn1 CHEMBL3659290 Ki 3.8 nM
Nc1ncc(-c2ccc(-c3cccnc3S(=O)(=O)C3CCCC3)cc2F)cn1 CHEMBL3700844 Ki 3.8 nM
Cc1ccc(COc2ccc3nc([C@@H]4CCCC[C@@H]4C(=O)O)n(Cc4ccc(N5CC(F)(F)C5)cc4)c3c2)nc1 CHEMBL3666986 Ki 3.8 nM
CCOC(=O)CNc1ccc(-c2nc(C3(c4ccc(-c5cnc(N)nc5)nc4)CCC3)no2)cn1 CHEMBL3684687 IC50 3.9 nM
Cn1ccc(COc2ccc3nc(C4CCCC[C@H]4C(=O)O)n(Cc4ccc(Br)cc4)c3c2)n1 CHEMBL3662268 Ki 3.9 nM
CN(C)c1cc(Oc2c(C3CCC3)ccc(-c3cnc(N)cn3)c2F)nc(C(F)(F)F)n1 CHEMBL3704293 Ki 3.9 nM
Cn1ccc(COc2ccc3nc(C4CCCC[C@@H]4C(=O)O)n(Cc4ccc(Br)cc4)c3c2)n1 CHEMBL3891878 Ki 3.9 nM
O=C(O)CSC(CCCc1ccccc1)(CCc1ccccc1)c1ccc(OCc2ccc3ccccc3n2)cc1 CHEMBL281308 IC50 4.0 nM
COc1ccc(-c2ccc(Cn3c(CC(C)(C)C(=O)O)c(SC(C)(C)C)c4cc(OCc5ccccn5)ccc43)cc2)nn1 CHEMBL552567 IC50 4.0 nM
CCC(=O)N1CCC[C@H]1COc1ccc2c(c1)c(SC(C)(C)C)c(CC(C)(C)C(=O)O)n2Cc1ccc(Cl)cc1 CHEMBL605917 IC50 4.0 nM
COC(=O)c1ccc(OCc2ccc3ccccc3n2)cc1[C@]1(c2ccccc2F)C[C@H]2CC[C@H]1C2 CHEMBL2031436 IC50 4.0 nM
Nc1ncc(-c2ccc(C3(c4noc(-c5cnn6cccnc56)n4)CCC3)cn2)cn1 CHEMBL3684699 IC50 4.0 nM
Nc1ncc(-c2ccc(C3(c4noc(-c5ccc6[nH]ncc6c5)n4)CCC3)cn2)cn1 CHEMBL3684752 IC50 4.0 nM
CC(C)(C)n1c(-c2cc(Br)cnc2-n2cncn2)nc2cc(-c3cnc(N)nc3)ccc21 CHEMBL3641490 IC50 4.0 nM
Cc1ccc(COc2ccc3nc(C4CCCC[C@@H]4C(=O)O)n(Cc4ccc(N5CCC(F)(F)CC5)cc4F)c3c2)nc1 CHEMBL3933160 Ki 4.0 nM
Nc1cnc(-c2ccc(C3CCC3)c(OCc3cccc(C(=O)O)c3)c2F)cn1 CHEMBL3704162 Ki 4.0 nM
CSc1ccnc(Oc2c(C3CCC3)ccc(-c3cnc(N)cn3)c2F)n1 CHEMBL3704246 Ki 4.0 nM
Cc1cc(C)nc(Oc2c(C3CCC3)ccc(-c3cnc(N)cn3)c2F)n1 CHEMBL3704247 Ki 4.0 nM
Nc1cnc(-c2ccc(C3CCC3)c(Oc3ncccc3Cl)c2F)cn1 CHEMBL3704276 Ki 4.0 nM
Nc1cnc(-c2ccc(-c3ccccc3S(=O)(=O)Nc3cccnc3)cc2F)cn1 CHEMBL3688422 Ki 4.0 nM
Nc1cnc(-c2ccc(-c3ccccc3S(=O)(=O)N3CCC(F)(F)C3)cc2F)cn1 CHEMBL3688442 Ki 4.0 nM
Nc1cnc(-c2ccc(-c3ccccc3S(=O)(=O)N3CC(F)(F)C3)cc2F)cn1 CHEMBL3688443 Ki 4.0 nM
Nc1cnc(-c2ccc(-c3ccccc3S(=O)(=O)NCCCO)cc2F)cn1 CHEMBL3688470 Ki 4.0 nM
Nc1cnc(-c2ccc(-c3ccccc3S(=O)(=O)N3CC[C@@H](CO)C3)cc2F)cn1 CHEMBL3700901 Ki 4.0 nM
CN([C@H]1CCCNC1)S(=O)(=O)c1ccccc1-c1ccc(-c2cnc(N)cn2)c(F)c1 CHEMBL3688494 Ki 4.0 nM
Nc1cnc(-c2ccc(-c3ccccc3S(=O)(=O)N3CCC(n4cn[nH]c4=O)CC3)cc2F)cn1 CHEMBL3688503 Ki 4.0 nM
N#CCCN(C1CC1)S(=O)(=O)c1ccccc1-c1ccc(-c2cnc(N)cn2)c(F)c1 CHEMBL3688534 Ki 4.0 nM
Nc1cnc(-c2ccc(-c3ccccc3SCCNC(=O)c3ccccc3)cc2F)cn1 CHEMBL3688562 Ki 4.0 nM
C[C@H](NS(=O)(=O)c1ccccc1-c1ccc(-c2cnc(N)nc2)c(F)c1)C(=O)OC(C)(C)C CHEMBL3693052 Ki 4.0 nM
CNS(=O)(=O)c1cc(C(F)(F)F)ccc1-c1ccc(-c2cnc(N)nc2)c(F)c1 CHEMBL3693070 Ki 4.0 nM
Nc1cncc(Sc2ccccc2-c2ccc(-c3cnc(N)nc3)c(F)c2)n1 CHEMBL3693080 Ki 4.0 nM
CCN(CC)S(=O)(=O)c1ccccc1-c1ccc(-c2ccc(N)nc2)c(F)c1 CHEMBL3693087 Ki 4.0 nM
Nc1ccc(-c2ccc(-c3ccccc3S(=O)(=O)N3CCC(CCO)CC3)cc2F)cn1 CHEMBL3693102 Ki 4.0 nM
CCSc1ccccc1-c1ccc(-c2cnc3[nH]ccc3n2)c(F)c1 CHEMBL3693125 Ki 4.0 nM
C[C@@H](CO)NS(=O)(=O)c1ccccc1-c1ccc(-c2cnc(N)c(C#N)n2)c(F)c1 CHEMBL3693150 Ki 4.0 nM
CC(C)(C)NS(=O)(=O)c1ccccc1-c1ccc(-c2cnc(N)c(N)n2)c(F)c1 CHEMBL3693168 Ki 4.0 nM
CC(C)(C)NS(=O)(=O)c1ccccc1-c1ccc(-c2cnc3[nH]cnc3c2)c(F)c1 CHEMBL3693171 Ki 4.0 nM
CC(C)(C)NS(=O)(=O)c1ccccc1-c1ccc(-c2cc(N)c3[nH]ccc3c2)c(F)c1 CHEMBL3693197 Ki 4.0 nM
CC(C)CS(=O)(=O)Nc1ccccc1-c1ccc(-c2cnc3[nH]ccc3n2)c(F)c1 CHEMBL3697179 Ki 4.0 nM
Nc1cc(Oc2cc(C(F)(F)F)ccc2-c2ccc(-c3cnc(N)nc3)c(F)c2)ncn1 CHEMBL3697243 Ki 4.0 nM
C[C@@H]([C@@H](O)c1ccccc1)N(C)S(=O)(=O)c1ccccc1-c1ccc(-c2cnc(N)c(F)c2)c(F)c1 CHEMBL3697336 Ki 4.0 nM
Cc1ccc(COc2ccc3nc(C4CCCC[C@H]4C(=O)O)n(Cc4ccc(N5CCC(F)(F)CC5)cc4F)c3c2)nc1 CHEMBL3666987 Ki 4.0 nM
CC(C)(CO)n1cc(-c2nc(C3(c4ccc(-c5cnc(N)nc5)cc4)CCC3)no2)cn1 CHEMBL4103286 IC50 4.0 nM
c1ccc(C2(c3cc(OCc4ccc5ccccc5n4)ccc3OCc3ccccn3)CC3CCC2C3)cc1 CHEMBL254747 IC50 4.1 nM
Nc1ncc(-c2ccc(C3(c4noc(-c5cccnc5Cl)n4)CCC3)cn2)cn1 CHEMBL3684756 IC50 4.1 nM
Cc1ccc(COc2ccc3nc([C@H]4CCCC[C@@H]4C(=O)O)n(Cc4ccc(OC(F)(F)F)cc4)c3c2)nc1 CHEMBL3920148 Ki 4.1 nM
O=C(O)[C@H]1CCCCC1c1nc2cc(OCc3ccc4ccccc4n3)ccc2n1Cc1cccc(-c2ncccn2)c1 CHEMBL3678486 Ki 4.1 nM
NC(=O)c1ccc(Oc2c(C3CCC3)ccc(-c3cnc(N)cn3)c2F)cc1 CHEMBL3704309 Ki 4.1 nM
Fc1c(-c2cnc3c(c2)OCCN3)ccc(C2CCC2)c1OCc1ccccc1 CHEMBL3704342 Ki 4.1 nM
Cc1ccc(COc2ccc3nc([C@@H]4CCCC[C@H]4C(=O)O)n(Cc4ccc(OC(F)(F)F)cc4)c3c2)nc1 CHEMBL3662262 Ki 4.1 nM
c1ccc(C2(c3cc(OCc4ccc5ccccc5n4)ccc3OCc3ccc4ccccc4n3)CCCCC2)cc1 CHEMBL404016 IC50 4.2 nM
Nc1ccc(-c2nc(C3(c4ccc(-c5cnc(N)nc5)nc4)CCC3)no2)cn1 CHEMBL3689119 IC50 4.2 nM
Cc1ncn(-c2ccc(C#N)nc2-c2nc3cc(-c4cnc(N)nc4)ccc3n2C(C)(C)C)n1 CHEMBL3641469 IC50 4.2 nM
Cn1cc(Cl)c(COc2ccc3nc([C@H]4CCCC[C@H]4C(=O)O)n(Cc4ccc(OC(F)(F)F)cc4F)c3c2)n1 CHEMBL3961020 Ki 4.2 nM
O=C(O)[C@H]1CCCC[C@H]1c1nc2cc(OCc3ccc4ccccc4n3)ccc2n1Cc1ccc(OC(F)(F)F)cc1F CHEMBL3678342 Ki 4.2 nM
Nc1cnc(-c2ccc(C3CCC3)c(OCCNc3cnccn3)c2F)cn1 CHEMBL3659322 Ki 4.2 nM
Cn1cc(Cl)c(COc2ccc3nc([C@@H]4CCCC[C@@H]4C(=O)O)n(Cc4ccc(OC(F)(F)F)cc4F)c3c2)n1 CHEMBL3666914 Ki 4.2 nM
CN(CCO)c1ccc(-c2nc(C3(c4ccc(-c5cnc(N)nc5)nc4)CCC3)no2)cn1 CHEMBL3689124 IC50 4.3 nM
Cc1ccc(COc2ccc3nc([C@H]4CCCC[C@H]4C(=O)O)n(Cc4ccc(OC(F)(F)F)cc4F)c3c2)nc1 CHEMBL3662258 Ki 4.3 nM
CS(=O)(=O)Nc1ccc(-c2cccc(Cn3c(C4CCCC[C@@H]4C(=O)O)nc4cc(OCc5ccc6ccccc6n5)ccc43)c2)cc1 CHEMBL3678435 Ki 4.3 nM
Cc1ccc(COc2ccc3nc(C4CCCC[C@@H]4C(=O)O)n(Cc4ccc(N5CCCC(F)(F)C5)cc4)c3c2)nc1 CHEMBL3954835 Ki 4.4 nM
Nc1cnc(-c2ccc(-c3ccccc3CSc3nccc(N)n3)cc2F)cn1 CHEMBL3688593 Ki 4.4 nM
Cc1ccc(COc2ccc3nc(C4CCCC[C@H]4C(=O)O)n(Cc4ccc(N5CCCC(F)(F)C5)cc4)c3c2)nc1 CHEMBL3666979 Ki 4.4 nM
c1ccc(C2(c3cc(OCc4ccc5ccccc5n4)ccc3OCc3ccc4ccccc4n3)CCCC2)cc1 CHEMBL404015 IC50 4.5 nM
CC(=O)N1c2ccccc2C[C@H]1COc1ccc2c(c1)c(S(=O)(=O)C(C)(C)C)c(CC(C)(C)C(=O)O)n2Cc1ccc(Cl)cc1 CHEMBL610471 IC50 4.5 nM
Cc1ccc(-c2nc(C3(c4ccc(-c5cnc(N)nc5)nc4)CCC3)no2)cn1 CHEMBL3684748 IC50 4.5 nM
Cc1ccc(COc2ccc3nc(C4CCCC[C@H]4C(=O)O)n(Cc4ccc(Br)cc4F)c3c2)nc1 CHEMBL3662243 Ki 4.5 nM
Cc1ccc(COc2ccc3nc(C4CCCC[C@@H]4C(=O)O)n(Cc4ccc(Br)cc4F)c3c2)nc1 CHEMBL3662246 Ki 4.5 nM
CCOc1ccc(-c2ccc(Cn3c(CC(C)(C)C(=O)O)c(SC(C)(C)C)c4cc(OCc5ccc(C)c[n+]5[O-])ccc43)cc2)cn1 CHEMBL1922668 IC50 4.6 nM
Nc1cnc(-c2ccc(-c3ccccc3Oc3cc(C4CC4)ncn3)cc2F)cn1 CHEMBL3697310 Ki 4.6 nM
Nc1cnc(Sc2ccccc2-c2ccc(-c3cnc(N)cn3)c(F)c2)cn1 CHEMBL3700782 Ki 4.6 nM
CC(=O)N1c2ccccc2C[C@H]1COc1ccc2c(c1)c(CCC(C)(C)C)c(CC(C)(C)C(=O)O)n2Cc1ccc(Cl)cc1 CHEMBL610469 IC50 4.7 nM
Nc1ncc(-c2ccc(C3(c4noc(-c5c[nH]nn5)n4)CCC3)cc2)cn1 CHEMBL3417423 IC50 4.7 nM
Cc1n[nH]cc1-c1nc(C2(c3ccc(-c4cnc(N)nc4)nc3)CCC2)no1 CHEMBL3689183 IC50 4.7 nM
Nc1cnc(-c2ccc(-c3ccc(C(F)(F)F)cc3-c3cnc(N)nc3)cc2F)cn1 CHEMBL3700888 Ki 4.7 nM
CC(C)(C)Sc1c(CC(C)(C)C(=O)O)n(Cc2ccc(-c3nccs3)cc2)c2ccc(OCc3ccccn3)cc12 CHEMBL539650 IC50 4.8 nM
Cc1cnc(-c2ccc(Cn3c(CC(C)(C)C(=O)O)c(SC(C)(C)C)c4cc(OCc5ccccn5)ccc43)cc2)s1 CHEMBL555209 IC50 4.8 nM
CS(=O)(=O)CCNc1ccc(-c2nc(C3(c4ccc(-c5cnc(N)nc5)nc4)CCC3)no2)cn1 CHEMBL3684725 IC50 4.8 nM
Cc1ccc(COc2ccc3nc(C4CCCC[C@@H]4C(=O)O)n(Cc4ccc(N5CCC(F)(F)C5)cc4F)c3c2)nc1 CHEMBL3948509 Ki 4.8 nM
N#Cc1ccc(Cn2c(C3CCCC[C@H]3C(=O)O)nc3cc(OCc4ccc5ccccc5n4)ccc32)cc1 CHEMBL3678336 Ki 4.8 nM
Cc1ccc(COc2ccc3nc(C4CCCC[C@H]4C(=O)O)n(Cc4ccc(N5CCC(F)(F)C5)cc4F)c3c2)nc1 CHEMBL3666988 Ki 4.8 nM
c1ccc(C2(c3cc(OCc4ccc5occc5n4)ccc3OCc3ccccn3)CC3CCC2C3)cc1 CHEMBL401597 IC50 4.9 nM
Cc1nc(N)cc(Oc2ccccc2-c2ccc(-c3cnc(N)cn3)c(F)c2)n1 CHEMBL3697300 Ki 4.9 nM
CC(C)(C)Sc1c(CC(C)(C)C(=O)O)n(Cc2ccc(Cl)cc2)c2ccc(OCc3cscn3)cc12 CHEMBL289751 IC50 5.0 nM
CC(C)(C)Sc1c(CC(C)(C)C(=O)O)n(Cc2ccc(Cl)cc2)c2ccc(OCc3nc4ccccc4o3)cc12 CHEMBL78854 IC50 5.0 nM
COC(=O)COc1ccc(OCc2ccc3ccccc3n2)cc1C1(c2ccccc2)CC2CCC1C2 CHEMBL404266 IC50 5.0 nM
Cc1nnc(-c2ccc(OCc3ccc4ccccc4n3)cc2[C@]2(c3ccccc3)C[C@H]3CC[C@H]2C3)o1 CHEMBL2031648 IC50 5.0 nM
NC(=O)CNc1ccc(-c2nc(C3(c4ccc(-c5cnc(N)nc5)nc4)CCC3)no2)cn1 CHEMBL3684676 IC50 5.0 nM
Nc1cnc(-c2ccc(C3CCC3)c(OCc3ccc(-c4nnn[nH]4)cc3)c2F)cn1 CHEMBL3704178 Ki 5.0 nM
Cc1cc(N)nc(Oc2c(C3CCC3)ccc(-c3cnc(N)cn3)c2F)n1 CHEMBL3704244 Ki 5.0 nM
CS(=O)(=O)c1ccnc(Oc2c(C3CCC3)ccc(-c3cnc(N)cn3)c2F)n1 CHEMBL3704251 Ki 5.0 nM
Nc1cnc(-c2ccc(C3CCC3)c(Oc3cc(C4CC4)ncn3)c2F)cn1 CHEMBL3704295 Ki 5.0 nM
Nc1cnc(-c2ccc(-c3ccccc3S(=O)(=O)N3CCN(C(=O)C4CC4)CC3)cc2F)cn1 CHEMBL3688448 Ki 5.0 nM
CC(C)C[C@@H](CO)NS(=O)(=O)c1ccccc1-c1ccc(-c2cnc(N)cn2)c(F)c1 CHEMBL3688469 Ki 5.0 nM
Nc1cnc(-c2ccc(-c3ccccc3S(=O)(=O)N3CCC[C@@H]3CO)cc2F)cn1 CHEMBL3700896 Ki 5.0 nM
CC(C)(C)[C@@H](CO)NS(=O)(=O)c1ccccc1-c1ccc(-c2cnc(N)cn2)c(F)c1 CHEMBL3688517 Ki 5.0 nM
Nc1cnc(-c2ccc(-c3ccccc3SCC3CNC(=O)O3)cc2F)cn1 CHEMBL3688561 Ki 5.0 nM
Nc1cnc(Sc2ccccc2-c2ccc(-c3cnc(N)cn3)c(F)c2)nc1 CHEMBL3688575 Ki 5.0 nM
Nc1cnc(-c2ccc(-c3ccccc3CSc3cc(N)ncn3)cc2F)cn1 CHEMBL3688594 Ki 5.0 nM
CC(C)(CO)CNS(=O)(=O)c1ccccc1-c1ccc(-c2cnc(N)nc2)c(F)c1 CHEMBL3688607 Ki 5.0 nM
Nc1ncc(-c2ccc(-c3ccccc3S(=O)(=O)N[C@H]3CCCC[C@H]3O)cc2F)cn1 CHEMBL3693008 Ki 5.0 nM
CC(C)(NS(=O)(=O)c1ccccc1-c1ccc(-c2cnc(N)nc2)c(F)c1)C(F)(F)F CHEMBL3693041 Ki 5.0 nM
C[C@H](NS(=O)(=O)c1ccccc1-c1ccc(-c2cnc(N)nc2)c(F)c1)C(F)(F)F CHEMBL3693042 Ki 5.0 nM
Nc1ccc(-c2ccc(-c3ccccc3S(=O)(=O)NC3CCCCC3)cc2F)cn1 CHEMBL3693090 Ki 5.0 nM
CC(C)CNS(=O)(=O)c1ccccc1-c1ccc(-c2ccc(N)nc2)c(F)c1 CHEMBL3693092 Ki 5.0 nM
CC(NS(=O)(=O)c1ccccc1-c1ccc(-c2ccc(N)nc2)c(F)c1)C(F)(F)F CHEMBL3693098 Ki 5.0 nM
Nc1ccc(-c2ccc(-c3ccccc3S(=O)(=O)N3CCC(CO)CC3)cc2F)cn1 CHEMBL3693104 Ki 5.0 nM
NC1CCN(S(=O)(=O)c2ccccc2-c2ccc(-c3cnc4[nH]ccc4n3)c(F)c2)CC1 CHEMBL3693123 Ki 5.0 nM
CC(C)(C)NS(=O)(=O)c1ccccc1-c1ccc(-c2cnc(N)c(F)c2)c(F)c1 CHEMBL3639920 Ki 5.0 nM
Nc1cnc(-c2ccc(-c3ccc(C(F)(F)F)cc3C(=O)N3CCOCC3)cc2F)cn1 CHEMBL3697205 Ki 5.0 nM
Nc1cnc(-c2ccc(-c3ccccc3Oc3nccc(N)n3)cc2F)cn1 CHEMBL3697212 Ki 5.0 nM
Nc1cnc(-c2ccc(-c3ccccc3Oc3ccnc(N)n3)cc2F)cn1 CHEMBL3697217 Ki 5.0 nM
Nc1ncc(-c2ccc(-c3ccc(C(F)(F)F)cc3Oc3ncccn3)cc2F)cn1 CHEMBL3697234 Ki 5.0 nM
Nc1ncc(-c2ccc(-c3ccc(C(F)(F)F)cc3Oc3ccnc(N)n3)cc2F)cn1 CHEMBL3697242 Ki 5.0 nM
Nc1cnc(-c2ccc(-c3ccc(C(F)(F)F)cc3C=O)cc2F)cn1 CHEMBL3697285 Ki 5.0 nM
Nc1ccc(Oc2ccccc2-c2ccc(-c3cnc(N)nc3)c(F)c2)nc1 CHEMBL3697298 Ki 5.0 nM
Nc1cnc(-c2ccc(-c3ccccc3S(=O)(=O)NCC3(O)CNC3)cc2F)cn1 CHEMBL3697331 Ki 5.0 nM
CNC(=O)c1ccc(F)cc1-c1nc2cc(-c3cnc(N)nc3)ccc2n1C(C)(C)C CHEMBL3681324 IC50 5.07 nM
Cc1cnc(COc2ccc3nc(CC(C)(C)C(=O)O)n(Cc4ccc(-c5ccc(C(F)(F)F)cc5)cc4F)c3c2)c(F)c1 CHEMBL3666969 Ki 5.1 nM
CS(=O)(=O)Nc1ccc(-c2cccc(Cn3c(CC4(C(=O)O)CCCC4)nc4cc(OCc5ccc6ccccc6n5)ccc43)c2)cc1 CHEMBL3678395 Ki 5.1 nM
Nc1cnc(-c2ccc(C3CCC3)c(Oc3cnc4cc(F)c(F)cc4n3)c2F)cn1 CHEMBL3659303 Ki 5.1 nM
Nc1cnc(-c2ccc(C3CCC3)c(Oc3nc4ncccc4s3)c2F)cn1 CHEMBL3659357 Ki 5.1 nM
COC(=O)c1ccc(OCc2ccc3ccccc3n2)cc1C1(c2ccccc2)CC(C)(C)C1 CHEMBL2031455 IC50 5.2 nM
CCC(CC)(Cc1nc2ccc(OCc3ncc(C)cc3F)cc2n1Cc1ccc(N2CCC(C)CC2)cc1F)C(=O)O CHEMBL3667006 Ki 5.2 nM
Nc1cnc(-c2ccc(-c3ccc(C(F)(F)F)cc3C(=O)N3CCS(=O)(=O)CC3)cc2F)cn1 CHEMBL3700796 Ki 5.2 nM
C[C@@](c1ccc(-c2cnc(N)nc2)cc1)(c1noc(N2CCC(O)CC2)n1)C1CC1 CHEMBL4081751 IC50 5.2 nM
NC(=O)c1cccc(COc2c(C3CCC3)ccc(-c3cnc4c(c3)OCCN4)c2F)c1 CHEMBL3704348 Ki 5.3 nM
Nc1cnc(-c2ccc(-c3ccccc3-c3cncc(N)n3)cc2F)cn1 CHEMBL3700877 Ki 5.3 nM
c1ccc([C@@]2(c3cc(OCc4ccc5ccccc5n4)ccc3-c3ncon3)C[C@H]3CC[C@H]2C3)cc1 CHEMBL2031650 IC50 5.4 nM
Cc1cc(Cn2c([C@H]3CCCC[C@H]3C(=O)O)nc3ccc(OCc4ccn(C)n4)cc32)ccc1OC(F)(F)F CHEMBL3897729 Ki 5.4 nM
Nc1cnc(-c2ccc(C3CCC3)c(Oc3cc(-c4ccccc4)ncn3)c2F)cn1 CHEMBL3704299 Ki 5.4 nM
N#Cc1nc(N)cnc1-c1ccc(C2CCC2)c(OCc2cccc(C(=O)O)c2)c1F CHEMBL3704329 Ki 5.4 nM
NC(=O)C1CCN(S(=O)(=O)c2ccccc2-c2ccc(-c3cnc(N)nc3)c(F)c2)CC1 CHEMBL3697375 Ki 5.4 nM
Cc1cc(Cn2c([C@@H]3CCCC[C@@H]3C(=O)O)nc3ccc(OCc4ccn(C)n4)cc32)ccc1OC(F)(F)F CHEMBL3666936 Ki 5.4 nM
CS(=O)(=O)CCOc1ccc(OCc2ccc3ccccc3n2)cc1C1(c2ccccc2)CC2CCC1C2 CHEMBL254547 IC50 5.5 nM
COc1ccc(-c2cccc(Cn3c(CC(C)(C)C(=O)O)c(SC(C)(C)C)c4cc(OCc5ccccn5)ccc43)c2)cn1 CHEMBL538708 IC50 5.5 nM
COC(=O)c1ccc(OCc2ccc3ccccc3n2)cc1[C@]1(c2cccc(C)c2)C[C@H]2CC[C@H]1C2 CHEMBL2031439 IC50 5.5 nM
COC(=O)c1ccc(OCc2ccc3ccccc3n2)cc1C(c1ccccc1)C(C)(C)C CHEMBL2031447 IC50 5.5 nM
Cc1cc(-c2nc(C3(c4ccc(-c5cnc(N)nc5)nc4)CCC3)no2)[nH]n1 CHEMBL3684753 IC50 5.5 nM
Nc1cnc(-c2ccc(C3CCC3)c(Oc3cc(N4CCC4)ncn3)c2F)cn1 CHEMBL3704292 Ki 5.5 nM
COC(=O)c1ccc(OCc2ccc3ccccc3n2)cc1C1(c2ccccc2)CC2CCC1C2 CHEMBL254564 IC50 5.6 nM
COC(=O)c1ccc(OCc2ccc3ccccc3n2)cc1C1(c2ccccc2)C2CCC1CC2 CHEMBL2031449 IC50 5.6 nM
Cc1ccc(COc2ccc3nc([C@H]4CCCC[C@H]4C(=O)O)n(Cc4ccc(OC(F)(F)F)c(Cl)c4)c3c2)nc1 CHEMBL3662263 Ki 5.6 nM
O=C(O)[C@H]1CCCCC1c1nc2cc(OCc3ccc4ccccc4n3)ccc2n1Cc1ccc(OC(F)(F)F)cc1 CHEMBL3678344 Ki 5.6 nM
CC(C)(Cc1nc2cc(OCc3ccc4ccccc4n3)ccc2n1Cc1cccc(-c2ccc(NS(C)(=O)=O)cc2)c1)C(=O)O CHEMBL3678465 Ki 5.6 nM
Nc1cnc(-c2ccc(C3CCC3)c(Oc3nccc(C(F)(F)F)n3)c2F)cn1 CHEMBL3704285 Ki 5.6 nM
CC(C)c1ccnc(Oc2c(C3CCC3)ccc(-c3cnc(N)nc3)c2F)n1 CHEMBL3704320 Ki 5.6 nM
CC1(O)CCN(c2nc([C@@](C)(c3ccc(-c4cnc(N)nc4)cc3)C3CC3)no2)CC1 CHEMBL4105047 IC50 5.6 nM
Nc1ncc(-c2ccc(C3(c4noc(-c5cnccn5)n4)CCC3)cc2)cn1 CHEMBL3417417 IC50 5.7 nM
O=C(O)[C@@H]1CCCC[C@@H]1c1nc2cc(OCc3ccc4cc(F)ccc4n3)ccc2n1Cc1ccc(Br)cc1 CHEMBL3678350 Ki 5.7 nM
O=C(Nc1cccnc1)c1ccc(OCc2ccc3ccccc3n2)cc1[C@]1(c2ccccc2)C[C@H]2CC[C@H]1C2 CHEMBL2031456 IC50 5.8 nM
Cc1ccc(-c2nc(C3(c4ccc(-c5cnc(N)nc5)nc4)CCC3)no2)cc1 CHEMBL3684680 IC50 5.8 nM
Cc1ccc(COc2cc(Cl)c3nc(C4CCCC[C@H]4C(=O)O)n(Cc4ccc(Br)cc4)c3c2)nc1 CHEMBL3666906 Ki 5.8 nM
Cc1ccccc1Cn1c([C@@H]2CCCC[C@@H]2C(=O)O)nc2cc(OCc3ccc4ccccc4n3)ccc21 CHEMBL3678339 Ki 5.8 nM
Nc1ccc(-c2ccc(-c3ccccc3S(=O)(=O)N3C[C@@H]4C[C@H]3CO4)cc2F)cn1 CHEMBL3697330 Ki 5.8 nM
Nc1ncc(-c2ccc(-c3cccnc3S(=O)(=O)C3CCCCC3)cc2F)cn1 CHEMBL3700842 Ki 5.8 nM
Cc1ccc(COc2cc(Cl)c3nc(C4CCCC[C@@H]4C(=O)O)n(Cc4ccc(Br)cc4)c3c2)nc1 CHEMBL3666908 Ki 5.8 nM
COC(=O)[C@@H]1CCCN1c1ccc(-c2nc(C3(c4ccc(-c5cnc(N)nc5)nc4)CCC3)no2)cn1 CHEMBL3684710 IC50 5.9 nM
Cc1ncnn1-c1ccc(C#N)nc1-c1nc2cc(-c3cnc(N)nc3)ccc2n1C(C)(C)C CHEMBL3641470 IC50 5.9 nM
COc1cc(OC(F)(F)F)ccc1Cn1c([C@H]2CCCC[C@H]2C(=O)O)nc2ccc(OCc3ccn(C)n3)cc21 CHEMBL3666915 Ki 5.9 nM
C[C@@H](COc1ccc2c(c1)c(SC(C)(C)C)c(CC(C)(C)C(=O)O)n2Cc1ccc(Cl)cc1)c1ccccn1 CHEMBL2114162 IC50 6.0 nM
CCCCOc1ccc(OCc2ccc3ccccc3n2)cc1C1(c2ccccc2)CC2CCC1C2 CHEMBL257621 IC50 6.0 nM
CC(=O)N1CCC[C@H]1COc1ccc2c(c1)c(SC(C)(C)C)c(CC(C)(C)C(=O)O)n2Cc1ccc(Cl)cc1 CHEMBL604687 IC50 6.0 nM
Nc1ncc(-c2ccc(C3(c4noc(-c5cncnc5)n4)CCC3)cc2)cn1 CHEMBL3417418 IC50 6.0 nM
Cc1ccc(COc2cc(F)c3nc(CC4(C(=O)O)CCCC4)n(Cc4ccc(Br)cc4)c3c2)nc1 CHEMBL3666892 Ki 6.0 nM
CCC(CC)(Cc1nc2c(F)cc(OCc3ccc(C)cn3)cc2n1Cc1ccc(Br)cc1)C(=O)O CHEMBL3666896 Ki 6.0 nM
Nc1cnc(-c2ccc(C3CCC3)c(OCc3ccccc3-c3nnn[nH]3)c2F)cn1 CHEMBL3704180 Ki 6.0 nM
CNS(=O)(=O)c1ccc(COc2c(C3CCC3)ccc(-c3cnc(N)cn3)c2F)cc1 CHEMBL3704185 Ki 6.0 nM
COc1cc(Oc2c(C3CCC3)ccc(-c3cnc(N)cn3)c2F)nc(N)n1 CHEMBL3704255 Ki 6.0 nM
Nc1cnc(-c2ccc(C3CCC3)c(Oc3nccc(N)n3)c2F)cn1 CHEMBL3704273 Ki 6.0 nM
CCNS(=O)(=O)c1ccccc1-c1ccc(-c2cnc(N)cn2)c(F)c1 CHEMBL3688412 Ki 6.0 nM
N#CC1CCCN(S(=O)(=O)c2ccccc2-c2ccc(-c3cnc(N)cn3)c(F)c2)C1 CHEMBL3688453 Ki 6.0 nM
Nc1cnc(-c2ccc(-c3ccccc3S(=O)(=O)N3CCCC(N)C3)cc2F)cn1 CHEMBL3688464 Ki 6.0 nM
Nc1cnc(-c2ccc(-c3ccccc3S(=O)(=O)N[C@H](CO)c3ccccc3)cc2F)cn1 CHEMBL3688471 Ki 6.0 nM
Nc1cnc(-c2ccc(-c3ccccc3S(=O)(=O)NC3CC3)cc2F)cn1 CHEMBL3688479 Ki 6.0 nM
Nc1cnc(-c2ccc(-c3ccccc3CSc3cccnn3)cc2F)cn1 CHEMBL3688595 Ki 6.0 nM
CC(C)N(CCO)S(=O)(=O)c1ccccc1-c1ccc(-c2cnc(N)nc2)c(F)c1 CHEMBL3693010 Ki 6.0 nM
Nc1cnc(-c2ccc(-c3ccccc3CS(=O)(=O)c3ccccc3)cc2F)cn1 CHEMBL3693218 Ki 6.0 nM
N#Cc1cccnc1Oc1ccccc1-c1ccc(-c2cnc(N)cn2)c(F)c1 CHEMBL3697216 Ki 6.0 nM
CC(C)(CO)NS(=O)(=O)c1ccccc1-c1ccc(-c2cnc(N)c(F)c2)c(F)c1 CHEMBL3697334 Ki 6.0 nM
CC(C)(C)n1c(-c2cc(C#N)ccc2C(=O)NC#N)nc2cc(-c3cnc(N)nc3)ccc21 CHEMBL3681328 IC50 6.09 nM
Nc1ncc(-c2ccc(C3(c4noc(-c5cnn(CC(F)F)c5)n4)CCC3)cn2)cn1 CHEMBL3684742 IC50 6.1 nM
CC(C)(C)c1ccc(-c2cnc(N)cn2)c(F)c1Oc1cc(N)ncn1 CHEMBL3704357 Ki 6.1 nM
CC(C)C(c1ccc(-c2cnc(N)nc2)cc1)c1noc(-c2cnn(C)c2)n1 CHEMBL3417516 IC50 6.2 nM
Nc1ncc(-c2ccc(C3(c4noc(-c5ccnnc5)n4)CCC3)cc2)cn1 CHEMBL3417416 IC50 6.2 nM
Cc1nccc(Oc2c(C3CCC3)ccc(-c3cnc(N)cn3)c2F)n1 CHEMBL3704288 Ki 6.2 nM
N#Cc1ccc(Oc2ccccc2-c2ccc(-c3cnc(N)cn3)c(F)c2)nc1 CHEMBL3697302 Ki 6.2 nM
Cc1noc(-c2ccc(OCc3ccc4ccccc4n3)cc2[C@]2(c3ccccc3)C[C@H]3CC[C@H]2C3)n1 CHEMBL2031459 IC50 6.3 nM
CC(C)(O)Cn1cc(-c2nc([C@@](C)(c3ccc(-c4cnc(N)nc4)nc3)C3CC3)no2)cn1 CHEMBL4096057 IC50 6.3 nM
CC(C)c1cc(Oc2c(C3CCC3)ccc(-c3cnc(N)cn3)c2F)ncn1 CHEMBL3704301 Ki 6.4 nM
CN(C)CCOc1ccc(OCc2ccc3ccccc3n2)cc1C1(c2ccccc2)CC2CCC1C2 CHEMBL438166 IC50 6.5 nM
Cc1ccc(-c2ccc(Cn3c(CC(C)(C)C(=O)O)c(SC(C)(C)C)c4cc(OCc5ccccn5)ccc43)cc2)cn1 CHEMBL553174 IC50 6.5 nM
Nc1ncc(-c2ccc(C3(c4noc(N5CCCCC5)n4)CCC3)cc2)cn1 CHEMBL4074281 IC50 6.5 nM
Cc1cc(-c2ccc(C(=O)[C@@H]3CCCC[C@H]3C(=O)Nc3cnn(C)c3S(N)(=O)=O)cc2)n[nH]1 CHEMBL4474619 fIC50 6.5 nM
CC(C)(Cc1c(CC2CCC2)c2cc(OCc3ccccn3)ccc2n1Cc1ccc(-c2nccs2)cc1)C(=O)O CHEMBL538955 IC50 6.6 nM
Cc1ccc(COc2ccc3nc([C@H]4CCCC[C@@H]4C(=O)O)n(Cc4ccc(-c5ccc(C(F)(F)F)cc5)cc4)c3c2)nc1 CHEMBL3917825 Ki 6.6 nM
Cn1ccc(COc2ccc3nc([C@H]4CCCC[C@H]4C(=O)O)n(Cc4ccc(OC(F)(F)F)cc4F)c3c2F)n1 CHEMBL3901015 Ki 6.6 nM
Cc1ccc(Cn2c([C@H]3CCCC[C@H]3C(=O)O)nc3ccc(OCc4ccc(C)cn4)cc32)cc1 CHEMBL3948568 Ki 6.6 nM
Cc1ccc(COc2ccc3nc([C@@H]4CCCC[C@H]4C(=O)O)n(Cc4ccc(-c5ccc(C(F)(F)F)cc5)cc4)c3c2)nc1 CHEMBL3662264 Ki 6.6 nM
Cn1ccc(COc2ccc3nc([C@@H]4CCCC[C@@H]4C(=O)O)n(Cc4ccc(OC(F)(F)F)cc4F)c3c2F)n1 CHEMBL3666922 Ki 6.6 nM
Cc1ccc(Cn2c([C@@H]3CCCC[C@@H]3C(=O)O)nc3ccc(OCc4ccc(C)cn4)cc32)cc1 CHEMBL3666947 Ki 6.6 nM
CC(C)[C@](C)(c1ccc(-c2cnc(N)nc2)nc1)c1noc(-c2cnn(C3COC3)c2)n1 CHEMBL4098484 IC50 6.6 nM
Cn1cc(-c2nc(C(C)(C)c3ccc(-c4cnc(N)nc4)cc3)no2)cn1 CHEMBL3417513 IC50 6.7 nM
N#CC1(S(=O)(=O)c2ccccc2-c2ccc(-c3cnc(N)cn3)c(F)c2)CCCC1 CHEMBL3700771 Ki 6.7 nM
COc1ccc(-c2ccc(Cn3c(CC(C)(C)C(=O)O)c(SC(C)(C)C)c4cc(OCc5ccccn5)ccc43)cc2)nc1 CHEMBL553175 IC50 6.8 nM
Cc1ccc(COc2ccc3nc(C4CCCC[C@@H]4C(=O)O)n(Cc4ccc(N5CCCCC5)cc4)c3c2)nc1 CHEMBL3943186 Ki 6.8 nM
Nc1cnc(-c2ccc(C3CCC3)c(OCCNc3ncccn3)c2F)cn1 CHEMBL3659323 Ki 6.8 nM
Cc1ccc(COc2ccc3nc(C4CCCC[C@H]4C(=O)O)n(Cc4ccc(N5CCCCC5)cc4)c3c2)nc1 CHEMBL3666982 Ki 6.8 nM
CC(C)(C)Sc1c(CC(C)(C)C(=O)O)n(Cc2ccc(-c3ncccn3)cc2)c2ccc(OCc3ccccn3)cc12 CHEMBL557052 IC50 6.9 nM
COC(=O)c1ccc(Oc2c(C3CCC3)ccc(-c3cnc(N)cn3)c2F)nc1 CHEMBL3704262 Ki 6.9 nM
CC(C)(C)c1ccc(-c2cnc(N)cn2)c(F)c1Oc1nccc(N)n1 CHEMBL3704358 Ki 6.9 nM
CC(C)(C)Sc1c(CC(C)(C)C(=O)O)n(Cc2ccc(Cl)cc2)c2ccc(OCc3cnccn3)cc12 CHEMBL79383 IC50 7.0 nM
CC(Oc1ccc2c(c1)c(SC(C)(C)C)c(CC(C)(C)C(=O)O)n2Cc1ccc(Cl)cc1)c1ccc2ccccc2n1 CHEMBL78938 IC50 7.0 nM
Nc1ncc(-c2ccc(-c3ccccc3S(=O)(=O)N[C@H](c3ccccc3)C(F)(F)F)cc2F)cn1 CHEMBL4113180 Ki 7.0 nM
Nc1ncc(-c2ccc(C3(c4noc(-c5cn[nH]c5)n4)CCC3)cn2)cn1 CHEMBL3689099 IC50 7.0 nM
Cn1ccc(COc2cc(F)c3nc([C@H]4CCCC[C@H]4C(=O)O)n(Cc4ccc(OC(F)(F)F)cc4F)c3c2)n1 CHEMBL3666927 Ki 7.0 nM
O=C(O)[C@H]1CCCC[C@H]1c1nc2cc(OCc3ccc4ccccc4n3)ccc2n1Cc1ccc(Br)cc1F CHEMBL3678319 Ki 7.0 nM
CS(=O)(=O)c1ccc(COc2c(C3CCC3)ccc(-c3cnc(N)cn3)c2F)cc1 CHEMBL3704165 Ki 7.0 nM
Cc1cc(Oc2c(C3CCC3)ccc(-c3cnc(N)cn3)c2F)nc(N)n1 CHEMBL3704252 Ki 7.0 nM
CS(=O)(=O)c1ccc(Oc2c(C3CCC3)ccc(-c3cnc(N)cn3)c2F)c(Cl)c1 CHEMBL3704277 Ki 7.0 nM
Nc1cnc(-c2ccc(C3CCC3)c(Oc3cnccn3)c2F)cn1 CHEMBL3659291 Ki 7.0 nM
Nc1cnc(-c2ccc(-c3ccccc3S(=O)(=O)N3CCOCC3)cc2F)cn1 CHEMBL3688435 Ki 7.0 nM
Nc1cnc(-c2ccc(-c3ccccc3S(=O)(=O)NCCO)cc2F)cn1 CHEMBL3688478 Ki 7.0 nM
Nc1cnc(-c2ccc(-c3ccccc3S(=O)(=O)N3CC[C@H](CO)C3)cc2F)cn1 CHEMBL3688493 Ki 7.0 nM
Nc1cnc(-c2ccc(-c3ccccc3NS(=O)(=O)N3CCCC3)cc2F)cn1 CHEMBL3688540 Ki 7.0 nM
CCS(=O)(=O)N(C)c1ccccc1-c1ccc(-c2cnc3[nH]ccc3n2)c(F)c1 CHEMBL3697177 Ki 7.0 nM
O=C(O)c1noc(-c2ccc(OCc3ccc4ccccc4n3)cc2)c1-c1ccc(Cl)cc1 CHEMBL3781006 IC50 7.0 nM
O=C(c1ccc(OCc2ccc3ccccc3n2)cc1[C@]1(c2ccccc2)C[C@H]2CC[C@H]1C2)N1CCCC1 CHEMBL2031458 IC50 7.1 nM
CC(C)(C)n1c(-c2nc(C#N)ccc2-n2cncn2)nc2cc(-c3cnc(N)nc3)ccc21 CHEMBL3641468 IC50 7.1 nM
CC(C)n1cc(-c2nc(C3(c4ccc(-c5cnc(N)nc5)nc4)CCC3)no2)cn1 CHEMBL3684738 IC50 7.2 nM
Cc1ccc(COc2ccc3nc(C4CCCCC4)n(Cc4cccc(-c5ccc(C(F)(F)F)cc5)c4)c3c2)nc1 CHEMBL3666973 Ki 7.2 nM
Cc1ccc(COc2ccc3nc(C4CCCC[C@@H]4C(=O)O)n(Cc4ccc(N5CC(F)(F)C5)cc4)c3c2)nc1 CHEMBL3906240 Ki 7.2 nM
COCc1cc(Oc2c(C3CCC3)ccc(-c3cnc(N)nc3)c2F)nc(N)n1 CHEMBL3704317 Ki 7.2 nM
Nc1cc(Oc2ccccc2-c2ccc(-c3cnc(N)nc3)c(F)c2)ccn1 CHEMBL3697313 Ki 7.2 nM
Cc1ccc(COc2ccc3nc(C4CCCCC4C(=O)O)n(Cc4cccc(-c5ccc(C(F)(F)F)cc5)c4)c3c2)nc1 CHEMBL3697393 Ki 7.2 nM
Cc1ccc(COc2ccc3nc(C4CCCC[C@H]4C(=O)O)n(Cc4ccc(N5CC(F)(F)C5)cc4)c3c2)nc1 CHEMBL3666985 Ki 7.2 nM
Cc1csc(-c2ccc(Cn3c(CC(C)(C)C(=O)O)c(SC(C)(C)C)c4cc(OCc5ccccn5)ccc43)cc2)n1 CHEMBL553403 IC50 7.3 nM
Nc1ncc(-c2ccc(C3(c4noc(-c5cnccc5Cl)n4)CCC3)cn2)cn1 CHEMBL3689097 IC50 7.3 nM
COc1ccc(-c2nc(C3(c4ccc(-c5cnc(N)nc5)nc4)CCC3)no2)c(OC)n1 CHEMBL3689105 IC50 7.3 nM
Cn1ccc(COc2ccc3nc([C@H]4CCCC[C@H]4C(=O)O)n(Cc4ccc(OC(F)(F)F)cc4)c3c2)n1 CHEMBL3662271 Ki 7.3 nM
CCC(CC)(Cc1nc2ccc(OCc3ccn(C)n3)cc2n1Cc1ccc(-c2ccc(C(F)(F)F)cc2)cc1F)C(=O)O CHEMBL3667011 Ki 7.3 nM
CC(C)[C@](C)(c1ccc(-c2cnc(N)nc2)cc1)c1noc(N2CCC(O)CC2)n1 CHEMBL4099770 IC50 7.3 nM
COC(=O)c1ccc(OCc2ccc3ccccc3n2)cc1[C@]1(c2cccc(C(F)(F)F)c2)C[C@H]2CC[C@H]1C2 CHEMBL2031440 IC50 7.4 nM
Nc1ncc(-c2ccc(C3(c4noc(-c5cnn(C(F)F)c5)n4)CCC3)cn2)cn1 CHEMBL3684740 IC50 7.4 nM
CNC(=O)c1ccc(C#N)cc1-c1nc2cc(-c3cnc(N)nc3)ccc2n1C(C)(C)C CHEMBL3681326 IC50 7.4 nM
Cc1cnc(COc2ccc3nc(CC(C)(C)C(=O)O)n(Cc4ccc(-c5ccc(C(F)(F)F)cc5)cc4)c3c2)c(F)c1 CHEMBL3666970 Ki 7.4 nM
Cc1cc(-c2ccc(C(=O)[C@@H]3CCCC[C@H]3C(=O)Nc3cn(C)nc3C)cc2)n[nH]1 CHEMBL4528928 fIC50 7.4 nM
Nc1ncc(-c2ccc(C3(c4noc(-c5ccc(Cl)nc5)n4)CCC3)cn2)cn1 CHEMBL3689108 IC50 7.5 nM
Cc1ccc(Cn2c([C@H]3CCCC[C@H]3C(=O)O)nc3c(F)cc(OCc4ccn(C)n4)cc32)cc1 CHEMBL3957708 Ki 7.5 nM
Cn1cc(-c2cccc(Cn3c(CC4(C(=O)O)CCCC4)nc4cc(OCc5ccc6ccccc6n5)ccc43)c2)cn1 CHEMBL3678397 Ki 7.5 nM
Cc1ccc(Cn2c([C@@H]3CCCC[C@@H]3C(=O)O)nc3c(F)cc(OCc4ccn(C)n4)cc32)cc1 CHEMBL3666928 Ki 7.5 nM
c1ccc(C2(c3cc(OCc4nc5ccccc5s4)ccc3OCc3ccccn3)CC3CCC2C3)cc1 CHEMBL402024 IC50 7.6 nM
Nc1ncc(-c2ccc(C3(c4noc(-c5cnn(CC(F)(F)F)c5)n4)CCC3)cn2)cn1 CHEMBL3684743 IC50 7.6 nM
CC(C)(C)Sc1c(CC(C)(C)C(=O)O)n(Cc2ccc(-c3cncnc3)cc2)c2ccc(OCc3ccccn3)cc12 CHEMBL555207 IC50 7.7 nM
CC(C)[C@@](C)(c1ccc(-c2cnc(N)nc2)cc1)c1noc(-c2cnn(C)c2)n1 CHEMBL3417519 IC50 7.7 nM
Nc1ncc(-c2ccc(C3(c4noc(-c5ccc(N6CCN[C@H](C(=O)O)C6)nc5)n4)CCC3)cn2)cn1 CHEMBL3684715 IC50 7.7 nM
Nc1ncc(-c2ccc(C3(c4noc(-c5ccc(N6CCN[C@@H](C(=O)O)C6)nc5)n4)CCC3)cn2)cn1 CHEMBL3684716 IC50 7.7 nM
Cc1ccc(COc2cc(F)c3nc(C4CCCC[C@H]4C(=O)O)n(Cc4ccc(OC(F)(F)F)cc4)c3c2)nc1 CHEMBL3666897 Ki 7.7 nM
COc1cc(Oc2c(C3CCC3)ccc(-c3cnc4[nH]ccc4n3)c2F)ncn1 CHEMBL3659260 Ki 7.7 nM
Cc1ccc(COc2cc(F)c3nc(C4CCCC[C@@H]4C(=O)O)n(Cc4ccc(OC(F)(F)F)cc4)c3c2)nc1 CHEMBL3666898 Ki 7.7 nM
Cn1ccc(COc2cc(F)c3nc(C4CCCC[C@@H]4C(=O)O)n(Cc4ccc(N5CC(F)(F)C5)cc4F)c3c2)n1 CHEMBL3666994 Ki 7.8 nM
Nc1cnc(Oc2c(C3CCC3)ccc(-c3cnc(N)cn3)c2F)nc1 CHEMBL3704312 Ki 7.8 nM
Nc1cnc(-c2ccc(-c3ccccc3Oc3cccc(C(F)(F)F)n3)cc2F)cn1 CHEMBL3697301 Ki 7.8 nM
Cn1ccc(COc2cc(F)c3nc(C4CCCC[C@@H]4C(=O)O)n(Cc4ccc(N5CC(F)(F)C5)cc4)c3c2)n1 CHEMBL3697395 Ki 7.8 nM
Nc1ncc(-c2ccc(C3(c4noc(-c5cnc(N6CCNCC6)cn5)n4)CCC3)cn2)cn1 CHEMBL3684734 IC50 7.9 nM
Cn1cc(Cl)c(COc2ccc3nc([C@H]4CCCC[C@H]4C(=O)O)n(Cc4ccc(N5CCCCC5)cc4)c3c2)n1 CHEMBL3930056 Ki 7.9 nM
CC(C)(C)NC(=O)c1cc(C(F)(F)F)ccc1-c1ccc(-c2cnc(N)cn2)c(F)c1 CHEMBL3700819 Ki 7.9 nM
Cn1cc(Cl)c(COc2ccc3nc([C@@H]4CCCC[C@@H]4C(=O)O)n(Cc4ccc(N5CCCCC5)cc4)c3c2)n1 CHEMBL3666913 Ki 7.9 nM
CC(COc1ccc2c(c1)c(SC(C)(C)C)c(CC(C)(C)C(=O)O)n2Cc1ccc(Cl)cc1)c1ccccn1 CHEMBL80696 IC50 8.0 nM
CC(C)(C)Sc1c(CC(C)(C)C(=O)O)n(Cc2ccc(Cl)cc2)c2ccc(OCc3cccc(Cl)n3)cc12 CHEMBL39617 IC50 8.0 nM
CC(C)(C)Sc1c(CC(C)(C)C(=O)O)n(Cc2ccc(Cl)cc2)c2ccc(OCc3ccc4c(n3)CCCC4)cc12 CHEMBL78201 IC50 8.0 nM
Nc1cnc(-c2ccc(-c3ccccc3S(=O)(=O)N3C[C@@H]4C(N)[C@@H]4C3)cc2F)cn1 CHEMBL3983007 Ki 8.0 nM
Cc1ccc(COc2ccc3nc([C@H]4CCCC[C@H]4C(=O)O)n(Cc4ccc(OC(F)(F)F)c(F)c4)c3c2)nc1 CHEMBL3662252 Ki 8.0 nM
Nc1cnc(-c2ccc(C3CCC3)c(OCc3cccc(-c4nnn[nH]4)c3)c2F)cn1 CHEMBL3704179 Ki 8.0 nM
Nc1cnc(-c2ccc(C3CCC3)c(OCc3ccccc3C(=O)O)c2F)cn1 CHEMBL3704204 Ki 8.0 nM
Nc1cnc(-c2ccc(C3CCC3)c(Oc3cc(O)ncn3)c2F)cn1 CHEMBL3704254 Ki 8.0 nM
CCCCCCS(=O)(=O)Nc1ccccc1-c1ccc(-c2cnc(N)cn2)c(F)c1 CHEMBL3688430 Ki 8.0 nM
C[C@@H](O)CNS(=O)(=O)c1ccccc1-c1ccc(-c2cnc(N)cn2)c(F)c1 CHEMBL3700898 Ki 8.0 nM
C[C@H](O)CNS(=O)(=O)c1ccccc1-c1ccc(-c2cnc(N)cn2)c(F)c1 CHEMBL3688484 Ki 8.0 nM
CS(=O)(=O)c1ccc(CSc2ccccc2-c2ccc(-c3cnc(N)cn3)c(F)c2)cc1 CHEMBL3688563 Ki 8.0 nM
CC(CO)(CO)NS(=O)(=O)c1ccccc1-c1ccc(-c2cnc(N)nc2)c(F)c1 CHEMBL3693004 Ki 8.0 nM
CSc1ccc(F)cc1-c1ccc(-c2cnc3[nH]ccc3n2)c(F)c1 CHEMBL3693124 Ki 8.0 nM
NS(=O)(=O)c1ccccc1-c1ccc(-c2cnc3c(c2)OCCN3)c(F)c1 CHEMBL3693128 Ki 8.0 nM
CC(C)Sc1ncccc1-c1ccc(-c2cnc(N)cn2)c(F)c1 CHEMBL3693136 Ki 8.0 nM
Nc1cnc(-c2ccc(-c3ccccc3Oc3ncccn3)cc2F)cn1 CHEMBL3697210 Ki 8.0 nM
N#Cc1cccnc1COc1ccccc1-c1ccc(-c2cnc(N)cn2)c(F)c1 CHEMBL3697215 Ki 8.0 nM
CC(C)(C)NS(=O)(=O)c1ccccc1-c1ccc(-c2coc(N)n2)c(F)c1 CHEMBL3697258 Ki 8.0 nM
Cn1ccc(COc2ccc3nc([C@@H]4CCCC[C@@H]4C(=O)O)n(Cc4ccc(OC(F)(F)F)cc4F)c3c2)n1 CHEMBL3662277 Ki 8.0 nM
Cc1cc(-c2ccc(C(=O)[C@@H]3CCCC[C@H]3C(=O)Nc3c(C)nn(C)c3C(N)=O)cc2)n[nH]1 CHEMBL4543414 fIC50 8.0 nM
Nc1ncc(-c2ccc(C3(c4noc(-c5cocn5)n4)CCC3)cc2)cn1 CHEMBL3417426 IC50 8.1 nM
Cc1nc(C)c(-c2nc(C3(c4ccc(-c5cnc(N)nc5)nc4)CCC3)no2)s1 CHEMBL3689103 IC50 8.1 nM
Cc1ccc(COc2cc(F)c3nc([C@H]4CCCC[C@@H]4C(=O)O)n(Cc4ccc(Br)cc4)c3c2)nc1 CHEMBL3666893 Ki 8.1 nM
Nc1cnc(-c2ccc(C3CCC3)c(OCC(O)Cn3c(=O)[nH]c4ccccc43)c2F)cn1 CHEMBL3659338 Ki 8.1 nM
Cn1cc(-c2ccccc2-c2ccc(-c3cnc(N)cn3)c(F)c2)cn1 CHEMBL3700882 Ki 8.1 nM
C[C@@](c1ccc(-c2cnc(N)nc2)nc1)(c1noc(-c2cnn(CC#N)c2)n1)C1CC1 CHEMBL4103813 IC50 8.1 nM
N#Cc1nc(N)cnc1-c1ccc(-c2ccc(C(F)(F)F)cc2S(=O)(=O)N2CCNC(=O)C2)cc1F CHEMBL3697381 Ki 8.2 nM
Cc1ccc(COc2ccc3c(c2)c(SC(C)(C)C)c(CC(C)(C)C(=O)O)n3Cc2ccc(-c3ccc(=O)[nH]c3)cc2)nc1 CHEMBL1922667 IC50 8.3 nM
Nc1cnc(-c2ccc(C3(c4noc(-c5cnn(C6COC6)c5)n4)CCC3)cn2)cn1 CHEMBL3689152 IC50 8.3 nM
CS(=O)(=O)c1ccc(Oc2c(C3CCC3)ccc(-c3cnc(N)cn3)c2F)nc1 CHEMBL3659270 Ki 8.3 nM
Nc1ncc(-c2ccc(C3(c4noc(N5CCCC5)n4)CCC3)cc2)cn1 CHEMBL4101030 IC50 8.3 nM
Cc1ccc(Cn2c(C3CCCC[C@H]3C(=O)O)nc3cc(OCc4ccc5ccccc5n4)ccc32)cc1 CHEMBL3678343 Ki 8.4 nM
N#Cc1nc(-c2ccc(-c3ccccc3Oc3nccc(N)n3)cc2F)cnc1N CHEMBL3697362 Ki 8.4 nM
COC(=O)c1ccc(OCc2ccc3ccccc3n2)cc1C1(c2ccccc2)CCCC1 CHEMBL2031451 IC50 8.5 nM
Nc1ncc(-c2ccc(C3(c4noc(-c5cccnn5)n4)CCC3)cc2)cn1 CHEMBL3417419 IC50 8.5 nM
Cc1cnc(COc2ccc3nc(CC(C)(C)C(=O)O)n(Cc4ccc(Br)cc4)c3c2)c(F)c1 CHEMBL3666956 Ki 8.5 nM
CC(C)(C)c1ccc(-c2cnc(N)cn2)c(F)c1Oc1ncccn1 CHEMBL3640032 Ki 8.5 nM
COc1cc(Oc2c(C3CCC3)ccc(-c3cnc4c(c3)OCCN4)c2F)ncn1 CHEMBL3659258 Ki 8.5 nM
C[C@H](CO)NC(=O)c1cc(C(F)(F)F)ccc1-c1ccc(-c2cnc(N)cn2)c(F)c1 CHEMBL3700820 Ki 8.5 nM
Nc1cnc(-c2ccc(-c3ccc(C(F)(F)F)cc3C(=O)N3CCC(O)CC3)cc2F)cn1 CHEMBL3700830 Ki 8.5 nM
CC(C)(C)S(=O)(=O)c1ncccc1-c1ccc(-c2cnc(N)cn2)c(F)c1 CHEMBL3700847 Ki 8.5 nM
c1ccc(COc2ccc(OCc3ccc4ccccc4n3)cc2C2(c3ccccc3)CC3CCC2C3)cc1 CHEMBL430038 IC50 8.6 nM
COc1ccc(OCc2ccc3ccccc3n2)cc1C1(c2ccccc2)CC2CCC1C2 CHEMBL256976 IC50 8.6 nM
CS(=O)(=O)c1cccc(COc2c(C3CCC3)ccc(-c3cnc4c(c3)OCCN4)c2F)c1 CHEMBL3704344 Ki 8.6 nM
Nc1ncc(-c2ccc(C3(c4noc(-c5ccc(S(N)(=O)=O)cc5)n4)CCC3)cn2)cn1 CHEMBL3684691 IC50 8.7 nM
COc1c(-c2ccc(C(F)(F)F)cc2)ccc(-c2cnc(N)cn2)c1F CHEMBL3697365 Ki 8.7 nM
Cc1cccc(-c2nc(C3(c4ccc(-c5cnc(N)nc5)nc4)CCC3)no2)c1 CHEMBL3684679 IC50 8.8 nM
CCn1cc(-c2nc(C3(c4ccc(-c5cnc(N)nc5)nc4)CCC3)no2)cn1 CHEMBL3684737 IC50 8.8 nM
N#Cc1cc(Oc2c(C3CCC3)ccc(-c3cnc(N)cn3)c2F)ccn1 CHEMBL3704264 Ki 8.9 nM
COC(=O)c1ccnc(Oc2c(C3CCC3)ccc(-c3cnc(N)cn3)c2F)n1 CHEMBL3704305 Ki 8.9 nM
CC(C)(C)Sc1c(CC(C)(C)C(=O)O)n(Cc2ccc(-c3cccnc3)cc2)c2ccc(OCc3ccccn3)cc12 CHEMBL538632 IC50 9.0 nM
Cc1ccc(COc2ccc3nc([C@H]4CCCC[C@@H]4C(=O)O)n(Cc4ccc(OC(F)(F)F)cc4F)c3c2)nc1 CHEMBL3662253 Ki 9.0 nM
O=C(O)[C@H]1CCCC[C@H]1c1nc2cc(OCc3ccc4ccccc4n3)ccc2n1Cc1ccccc1 CHEMBL3678337 Ki 9.0 nM
Nc1cnc(-c2ccc(-c3ccccc3S(=O)(=O)N3CC[C@H](O)C3)cc2F)cn1 CHEMBL3688543 Ki 9.0 nM
CC(C)[C@H](CO)NS(=O)(=O)c1ccccc1-c1ccc(-c2cnc(N)nc2)c(F)c1 CHEMBL3693022 Ki 9.0 nM
Nc1ncc(-c2ccc(-c3ccccc3S(=O)(=O)NCC3CC3)cc2F)cn1 CHEMBL3693030 Ki 9.0 nM
Cc1cccc(-c2ccc(-c3cnc(N)nc3)c(F)c2)c1S(=O)(=O)NC(C)(C)C CHEMBL3693034 Ki 9.0 nM
CC(C)S(=O)(=O)c1ncccc1-c1ccc(-c2cnc(N)cn2)c(F)c1 CHEMBL3693135 Ki 9.0 nM
CC(C)(C)NS(=O)(=O)c1ccccc1-c1ccc(-c2ncc(N)nc2C#N)c(F)c1 CHEMBL3693174 Ki 9.0 nM
COc1cnc(Oc2ccccc2-c2ccc(-c3cnc(N)cn3)c(F)c2)nc1 CHEMBL3697232 Ki 9.0 nM
C[C@@H](NC(=O)c1cc(C(F)(F)F)ccc1-c1ccc(-c2cnc(N)cn2)c(F)c1)C(F)(F)F CHEMBL3700822 Ki 9.1 nM
Cn1cc(-c2nc(C3(c4ccc(-c5cnc(N)nc5)nc4)CCC3)no2)c(C(F)(F)F)n1 CHEMBL3684694 IC50 9.2 nM
CC1(C)CCC(Cc2nc3cc(OCc4ccc5ccccc5n4)ccc3n2Cc2ccc(Br)cc2)(C(=O)O)C1 CHEMBL3678320 Ki 9.2 nM
Cc1c(CC(C)(C)C(=O)O)n(Cc2ccc(Cl)cc2)c2ccc(OCc3ccc(-c4ccccc4)cn3)cc12 CHEMBL297661 IC50 9.3 nM
COC(=O)COc1ccc(OCc2ccc3ccccc3n2)cc1C1(c2ccccc2)CCCC1 CHEMBL255013 IC50 9.3 nM
COc1ccc(-c2ccc(Cn3c(CC(C)(C)C(=O)O)c(SC(C)(C)C)c4cc(OC[C@@H]5Cc6ccccc6N5C(C)=O)ccc43)cc2)cn1 CHEMBL610473 IC50 9.3 nM
O=C(O)C1(Cc2nc3cc(OCc4ccc5ccccc5n4)ccc3n2Cc2ccc(F)cc2)CCCC1 CHEMBL3678356 Ki 9.3 nM
O=C(O)C1(Cc2nc3cc(OCc4ccc5ccccc5n4)ccc3n2Cc2ccc(Cl)cc2)CCCC1 CHEMBL3678361 Ki 9.3 nM
COC(=O)c1ccc(OCc2ccc3ccccc3n2)cc1[C@]1(c2ccc(F)cc2)C[C@H]2CC[C@H]1C2 CHEMBL2031438 IC50 9.5 nM
Nc1ncc(-c2ccc(C3(c4noc(-c5cnn(CCF)c5)n4)CCC3)cn2)cn1 CHEMBL3684741 IC50 9.5 nM
Nc1cnc(-c2ccc(C3CCCCC3)c(Oc3nccc(N)n3)c2F)cn1 CHEMBL3659352 Ki 9.5 nM
COc1cc(-c2nc(C3(c4ccc(-c5cnc(N)nc5)nc4)CCC3)no2)ccn1 CHEMBL3689102 IC50 9.6 nM
Cn1ccc(COc2ccc3nc([C@H]4CCCC[C@@H]4C(=O)O)n(Cc4ccc(OC(F)(F)F)cc4)c3c2)n1 CHEMBL3662279 Ki 9.7 nM
Cn1ccc(COc2ccc3nc([C@H]4CCCC[C@H]4C(=O)O)n(Cc4ccc(N5CCC(F)(F)CC5)cc4)c3c2)n1 CHEMBL3921519 Ki 9.7 nM
Cc1cccc(Cn2c(C3CCCC[C@@H]3C(=O)O)nc3cc(OCc4ccc5ccccc5n4)ccc32)c1 CHEMBL3678347 Ki 9.7 nM
NC(=O)c1ncc(Oc2c(C3CCC3)ccc(-c3cnc(N)cn3)c2F)cn1 CHEMBL3659356 Ki 9.7 nM
Cn1ccc(COc2ccc3nc([C@@H]4CCCC[C@@H]4C(=O)O)n(Cc4ccc(N5CCC(F)(F)CC5)cc4)c3c2)n1 CHEMBL3666917 Ki 9.7 nM
Cc1ccc(COc2c(C3CCC3)ccc(-c3cnc4c(c3)OCCN4)c2F)cc1 CHEMBL3704345 Ki 9.8 nM