CC(C)(C)NC(=O)c1ccc(OC/C(=C/F)CN)cc1 CHEMBL3897599 IC50 5.0 nM
Cc1cc(/C=C/C(=O)O)cnc1N1CCN(c2ncc(-c3cccc(CN(C)C(=O)CN)c3)cn2)CC1 CHEMBL3643999 IC50 6.9 nM
CN(Cc1cccc(-c2cnc(N3CC=C(c4cccnc4)CC3)nc2)c1)C(=O)CN CHEMBL3644015 IC50 7.0 nM
N=C(N)NC(=O)OCc1cccc(-c2cnc(N3CCOCC3)nc2)c1F CHEMBL4077021 IC50 9.2 nM
Cc1cc(CCC(=O)O)cnc1N1CCN(c2ncc(-c3cccc(CN(C)C(=O)CN)c3)cn2)CC1 CHEMBL3644003 IC50 9.4 nM
NC/C=C(/F)COc1ccc(C(=O)NC2CCCCC2)cc1 CHEMBL2029546 IC50 10.0 nM
CN(Cc1cccc(-c2cnc(N3Cc4cccnc4C3)nc2)c1)C(=O)CN CHEMBL3644011 IC50 11.0 nM
N=C(N)NC(=O)OCc1cccc(N2CCN(c3ccncc3)CC2)c1 CHEMBL4087881 IC50 13.0 nM
CN(Cc1cccc(-c2cnc(N3CCS(=O)(=O)CC3)nc2)c1)C(=O)CN CHEMBL3644016 IC50 17.0 nM
N=C(N)NC(=O)OCc1cccc(N2CCN(c3cccnc3)CC2)c1F CHEMBL4068948 IC50 17.0 nM
CN(Cc1cccc(-c2cnc(N3CCN(c4ncc(C(=O)O)cc4Cl)CC3)nc2)c1)C(=O)CN CHEMBL3644000 IC50 18.0 nM
Cc1ncccc1N1CCN(c2ncc(-c3cccc(CN(C)C(=O)CN)c3)cn2)CC1 CHEMBL3644010 IC50 18.0 nM
CC(=O)Nc1nc(CCc2ccc(Cc3c[nH]c(N)n3)cc2)cs1 CHEMBL2392121 IC50 19.0 nM
NNCCc1ccccc1 CHEMBL1089 pIC50 19.95 nM
CCNc1cncc(N(C)CC)c1CN CHEMBL537623 IC50 20.0 nM
CSc1ccc(OC/C(F)=C\CN)cc1 CHEMBL2029534 IC50 20.0 nM
NC/C=C(/F)COc1ccc(C(=O)NC2CCCC2)cc1 CHEMBL2029545 IC50 20.0 nM
NC/C(=C/F)CCc1ccc(F)cc1 CHEMBL489079 IC50 20.0 nM
CC(=O)Nc1nc(CCc2ccc(NC(=N)N)cc2)c(Cc2ccc(S(C)(=O)=O)cc2)s1 CHEMBL2376161 IC50 20.0 nM
CN1CCN(c2ccc(Nc3cc(=O)n(-c4ccc(Cl)cc4)nc3-c3nc[nH]n3)cc2)CC1 CHEMBL3110302 IC50 20.0 nM
O=c1ccc(=O)[nH][nH]1 CHEMBL1489913 IC50 20.0 nM
Cc1nc2c(s1)CN(c1ncc(-c3cccc(CN(C)C(=O)CN)c3)cn1)CC2 CHEMBL3644012 IC50 20.0 nM
CN(Cc1cccc(-c2cnc(N3CCC(c4cccnc4)CC3)nc2)c1)C(=O)CN CHEMBL3644014 IC50 23.0 nM
N=C(N)NC(=O)OCc1cccc(N2CC(Oc3cccnc3)C2)c1F CHEMBL4102044 IC50 24.0 nM
CN(Cc1cccc(-c2cnc(N3CCN(c4ccc(C(=O)O)cc4)CC3)nc2)c1)C(=O)CN CHEMBL4074717 IC50 24.0 nM
CN(Cc1cccc(-c2cnc(N3CCN(c4ccc(C(=O)O)cc4Cl)CC3)nc2)c1)C(=O)CN CHEMBL3644018 IC50 25.0 nM
Cc1ccc(OC2CN(c3cccc(COC(=O)NC(=N)N)c3F)C2)cn1 CHEMBL4094310 IC50 25.0 nM
CN(Cc1cccc(-c2cnc(N3CCN(c4ccc(C(=O)O)cc4Cl)CC3)nc2)c1)C(=O)CN CHEMBL4063342 IC50 25.0 nM
COc1ccc(C(O)CNN)cc1 CHEMBL1241119 pIC50 28.84 nM
C[C@@H](NC(=O)c1ccc(OC/C(F)=C\CN)cc1)c1ccccc1 CHEMBL2029549 IC50 30.0 nM
CN(Cc1cccc(-c2cnc(N3CCN(c4ncc(/C=C/C(=O)O)cc4Cl)CC3)nc2)c1)C(=O)CN CHEMBL3644001 IC50 31.0 nM
N=C(N)NC(=O)OCc1cccc(N2CCN(c3cccnc3)CC2)c1 CHEMBL4098023 IC50 31.0 nM
CN(Cc1cccc(-c2cnc(N3CCOCC3)nc2)c1)C(=O)CN CHEMBL4077840 IC50 31.0 nM
CN(CC(N)=O)Cc1cccc(-c2cnc(N3CCOCC3)nc2)c1 CHEMBL4068336 IC50 31.0 nM
Cc1cccnc1N1CCN(c2ncc(-c3cccc(CN(C)C(=O)CN)c3)cn2)CC1 CHEMBL3643997 IC50 32.0 nM
CN(Cc1cccc(-c2cnc(N3CCOCC3)nc2)c1)C(=O)CN CHEMBL3644004 IC50 32.0 nM
CC(=O)Nc1nc(CCc2ccc(NC(=N)N)cc2)c(-c2ccc(S(C)(=O)=O)cc2)s1 CHEMBL2376169 IC50 34.0 nM
CC(C)C1c2[nH]cnc2CCN1C(=O)OCc1cccnc1 CHEMBL3655077 IC50 34.0 nM
CC(=O)Nc1nc(CCc2ccc(NC(=N)N)cc2)c(Cc2cccc(S(C)(=O)=O)c2)s1 CHEMBL2376162 IC50 36.0 nM
NNC[C@H](O)c1ccccc1 CHEMBL1766380 IC50 40.0 nM
NC/C=C(/F)COc1ccc(C(F)(F)F)cc1 CHEMBL2029539 IC50 40.0 nM
CC(NC(=O)c1ccc(OC/C(F)=C\CN)cc1)c1ccccc1 CHEMBL2029548 IC50 40.0 nM
C[C@H](NC(=O)c1ccc(OC/C(F)=C\CN)cc1)c1ccccc1 CHEMBL2029550 IC50 40.0 nM
Cc1ncccc1OC1CN(c2cccc(COC(=O)NC(=N)N)c2F)C1 CHEMBL4077779 IC50 40.0 nM
N=C(N)NC(=O)OCc1cccc(N2CCC(Oc3cccnc3)CC2)c1F CHEMBL4095186 IC50 45.0 nM
CN(CC(N)=O)Cc1cccc(-c2cnc(N3CCC(CCO)CC3)nc2)c1 CHEMBL4082458 IC50 45.0 nM
N=C(N)NC(=O)OCc1cccc(-c2cnc(N3CCOCC3)nc2)c1 CHEMBL4066376 IC50 47.0 nM
CC(C)C1c2[nH]cnc2CCN1C(=O)OCCOc1ccccc1 CHEMBL3655078 IC50 48.0 nM
CN(Cc1cccc(-c2cnc(N3CCC(N4CCOCC4)CC3)nc2)c1)C(=O)CN CHEMBL3644002 IC50 48.0 nM
CN(Cc1cccc(-c2cnc(N3CC[C@H](F)C3)nc2)c1)C(=O)CN CHEMBL3643998 IC50 49.0 nM
CN(Cc1cccc(-c2cnc(N3CCCC3)nc2)c1)C(=O)CN CHEMBL3644005 IC50 49.0 nM
C[C@H](NS(=O)(=O)c1ccc(OC/C(F)=C\CN)cc1)c1ccccc1 CHEMBL4562149 pIC50 50.12 nM
COc1cccc(C(O)CNN)c1 CHEMBL1241071 pIC50 52.48 nM
CC(=O)Nc1nc(CCc2ccc(NC(=N)N)cc2)c(Cc2ccc(S(N)(=O)=O)cc2)s1 CHEMBL2375367 IC50 53.0 nM
N=C(N)NC(=O)Cc1cccc(CCc2cnc(N3CCOCC3)nc2)c1 CHEMBL4071187 IC50 54.0 nM
CN(CC(N)=O)Cc1cccc(-c2ccc(N3CCOCC3)nc2)c1 CHEMBL4096880 IC50 55.0 nM
N=C(N)NC(=O)Cc1cccc(-c2cnc(N3CCOCC3)nc2)c1 CHEMBL4103619 IC50 56.0 nM
CC(CNN)c1ccccc1 CHEMBL1241428 pIC50 58.88 nM
COc1ccc(CCN(C)N)cc1 CHEMBL1240954 pIC50 60.26 nM
C[C@@H]1CN(c2ncc(-c3cccc(CN(C)C(=O)CN)c3)cn2)C[C@H](C)O1 CHEMBL3644006 IC50 61.0 nM
NNCC(O)c1ccccc1 CHEMBL1241070 pIC50 64.57 nM
CN(Cc1cccc(-c2cnc(N3CCOC(CO)C3)nc2)c1)C(=O)CN CHEMBL3644007 IC50 66.0 nM
NC/C=C(/F)COc1ccc([N+](=O)[O-])cc1 CHEMBL2029537 IC50 70.0 nM
CN(N)CCc1ccc(Cl)cc1 CHEMBL1240910 pIC50 70.79 nM
O=c1cc(NC2CCCCC2)c(-c2nc[nH]n2)nn1-c1ccccc1 CHEMBL3110303 IC50 71.0 nM
CN(Cc1cccc(-c2cnc(N3CCN(c4ncccc4Cl)CC3)nc2)c1)C(=O)CN CHEMBL3644013 IC50 72.0 nM
N=C(N)NC(=O)OCc1ccc(F)c(-c2cnc(N3CCOCC3)nc2)c1F CHEMBL4076616 IC50 77.0 nM
CCN(N)CCc1ccc(OC)cc1 CHEMBL1241004 pIC50 79.43 nM
NC/C=C(/F)COc1ccc(C(=O)NCc2ccccc2)cc1 CHEMBL2029547 IC50 80.0 nM
C[C@@H]1CN(c2ccc(-c3cccc(CN(C)C(=O)CN)c3)cn2)C[C@H](C)O1 CHEMBL3644008 IC50 81.0 nM
CN(Cc1cccc(-c2ccc(NC(=O)N3CCOCC3)cc2)c1)C(=O)CN CHEMBL3964548 IC50 83.0 nM
COc1cccc(CCN(C)N)c1 CHEMBL1240912 pIC50 89.13 nM
CN(Cc1cccc(-c2cnc(N3CCN(c4ccc(C#N)nc4)CC3)nc2)c1)C(=O)CN CHEMBL3644017 IC50 90.0 nM
CC(C)C1c2[nH]cnc2CCN1C(=O)OCC1CCOC1 CHEMBL3655079 IC50 91.0 nM
CN(N)CCc1ccccc1F CHEMBL1240878 pIC50 91.2 nM
N=C(N)NC(=O)OCc1ccc(F)c(-c2cnc(N3CCOCC3)nc2)c1 CHEMBL4095865 IC50 99.0 nM
CN(N)CCc1ccc(F)cc1 CHEMBL1240879 pIC50 109.65 nM
CN(N)CCc1ccccc1 CHEMBL1240877 pIC50 109.65 nM
N=C(N)NC(=O)OCc1cccc(N2CCN(C3CCOCC3)CC2)c1 CHEMBL4059565 IC50 110.0 nM
CN(N)CCc1cccc(Cl)c1 CHEMBL1240909 pIC50 120.23 nM
CCSc1cncc(SCC)c1CN CHEMBL538353 IC50 130.0 nM
CN(CC(N)=O)Cc1cccc(-c2cnc(N3CCC(O)CC3)nc2)c1 CHEMBL4092744 IC50 130.0 nM
NC/C=C(/F)COc1ccc(C(=O)N2CCCC2)cc1 CHEMBL2029543 IC50 140.0 nM
CN(Cc1cccc(-c2cnc(N3CCC(O)CC3)nc2)c1)C(=O)CN CHEMBL3644009 IC50 140.0 nM
N=C(N)NC(=O)OCc1cccc(N2CCN(c3ccccn3)CC2)c1 CHEMBL4079999 IC50 140.0 nM
CN(Cc1cccc(-c2cnc(N3CCC(CCC(=O)O)CC3)nc2)c1)C(=O)CN CHEMBL4101409 IC50 140.0 nM
NCc1c(OCCCCO)cncc1OCCCCO CHEMBL536484 IC50 150.0 nM
NNC[C@@H](O)c1ccccc1 CHEMBL1766381 IC50 150.0 nM
NC/C=C(/F)COc1cccc(C(F)(F)F)c1 CHEMBL2029540 IC50 150.0 nM
CC(=O)Nc1nc(CCc2ccc(NC(=N)N)cc2)c(Cc2ccc(S(=O)(=O)N(C)C)cc2)s1 CHEMBL2376166 IC50 150.0 nM
COc1ccc(OC/C(F)=C\CN)cc1 CHEMBL2029531 IC50 160.0 nM
CC(=O)Nc1nc(CCc2ccc(NC(=N)N)cc2)c(CCc2ccc(S(C)(=O)=O)cc2)s1 CHEMBL2376164 IC50 160.0 nM
N=C(N)NC(=O)OCc1cccc(N2CCC(N3CCOCC3)CC2)c1 CHEMBL4060583 IC50 160.0 nM
CN(N)CCc1ccccc1Cl CHEMBL1240908 pIC50 169.82 nM
CCOc1cncc(OCC)c1CN CHEMBL537401 IC50 170.0 nM
NC/C=C(/F)COc1ccc(OC(F)(F)F)cc1 CHEMBL2029536 IC50 180.0 nM
NCC(=O)NCc1cccc(-c2ccccc2)c1 CHEMBL3919913 IC50 180.0 nM
CCN(N)CCc1ccccc1 CHEMBL1241003 pIC50 181.97 nM
NC/C=C(/F)COc1ccc(F)c(F)c1 CHEMBL2029538 IC50 190.0 nM
CN(N)CC(O)c1ccc2c(c1)OCCO2 CHEMBL1241167 pIC50 199.53 nM
CC(C)Nc1cc(=O)n(-c2ccccc2)nc1-c1nc[nH]n1 CHEMBL3110304 Kd 200.0 nM
CN(N)CC(O)c1ccccc1 CHEMBL1241120 pIC50 208.93 nM
CC(C)(C)c1ccc(OC/C(F)=C\CN)cc1 CHEMBL2029535 IC50 210.0 nM
CC(=O)Nc1nc(CCc2ccc(NC(=N)N)cc2)c(Cc2ccccc2)s1 CHEMBL2376163 IC50 210.0 nM
COc1ccc(C(O)CN(C)N)c(OC)c1OC CHEMBL1241166 pIC50 218.78 nM
COC(CN(C)N)c1ccc2ccccc2c1 CHEMBL1241378 pIC50 229.09 nM
CC(=O)Nc1nc(CCc2ccc(NC(=N)N)cc2)cs1 CHEMBL2326864 IC50 230.0 nM
CN(N)CCCc1ccccc1 CHEMBL1241069 pIC50 239.88 nM
NC/C=C(/F)COc1ccc(Oc2ccccc2)cc1 CHEMBL2029532 IC50 240.0 nM
CN(Cc1cccc(-c2ccc(Cl)cc2)c1)C(=O)CN CHEMBL3894903 IC50 240.0 nM
CN(CC(N)=O)Cc1cccc(-c2cnc(N3CCC[C@H]3CO)nc2)c1 CHEMBL4071971 IC50 240.0 nM
NC/C=C(/F)COc1cccc(Cl)c1 CHEMBL2029533 IC50 250.0 nM
CN(CC(N)=O)Cc1cccc(-c2cnc(N3CCCCC3)nc2)c1 CHEMBL4076388 IC50 250.0 nM
CCC[C@@H]([C@H](O)c1ccccc1)N(C)N CHEMBL1241289 pIC50 257.04 nM
CC[C@@H]([C@H](O)c1ccccc1)N(C)N CHEMBL1241263 pIC50 257.04 nM
COc1ccc(CCN(N)CC(C)C)cc1 CHEMBL1241068 pIC50 257.04 nM
CN(Cc1ccccc1)C(=O)c1ccc(OC/C(F)=C\CN)cc1 CHEMBL2029544 IC50 260.0 nM
CN(N)Cc1ccccc1 CHEMBL1241379 pIC50 269.15 nM
CN(N)CC(O)c1ccccc1Cl CHEMBL1241121 pIC50 269.15 nM
CN(N)[C@@H](c1ccccc1)[C@H](O)c1ccccc1 CHEMBL1766384 IC50 280.0 nM
CN(C)C(=O)Nc1ccc(-c2cccc(CN(C)C(=O)CN)c2)cc1 CHEMBL3941188 IC50 280.0 nM
COc1cccc(C(O)CN(C)N)c1 CHEMBL1241123 pIC50 281.84 nM
NC/C=C(/F)COc1ccccc1 CHEMBL2029527 IC50 290.0 nM
CN(CC(N)=O)Cc1cccc(-c2cnc(N3CCC[C@@H]3CO)nc2)c1 CHEMBL4059576 IC50 300.0 nM
COc1ccc(C(O)CN(C)N)cc1 CHEMBL1241164 pIC50 309.03 nM
CN(N)CC(O)c1ccc(Cl)cc1 CHEMBL1241122 pIC50 309.03 nM
COC(=O)c1ccc(Cc2sc(NC(C)=O)nc2CCc2ccc(NC(=N)N)cc2)cc1 CHEMBL2376165 IC50 320.0 nM
COC(CN(C)N)c1cccc(C)c1 CHEMBL1241330 pIC50 323.59 nM
CN(N)CC(O)c1ccc(F)cc1 CHEMBL1241165 pIC50 323.59 nM
COc1cc(CCN(C)N)cc(OC)c1OC CHEMBL1241002 pIC50 323.59 nM
CN(N)[C@H](c1ccccc1)[C@@H](O)c1ccccc1 CHEMBL1766387 IC50 330.0 nM
CC(=O)Nc1nc(-c2ccc(CCNC(=N)N)cc2)cs1 CHEMBL2326875 IC50 330.0 nM
CN1CCN(c2ccc(-c3cccc(CN(C)C(=O)CN)c3)cc2)CC1 CHEMBL3960949 IC50 330.0 nM
COc1ccc(CCN(C)N)c(OC)c1OC CHEMBL1240957 pIC50 331.13 nM
CN(Cc1cccc(-c2ccc(N3CCOCC3)cc2)c1)C(=O)CN CHEMBL3923237 IC50 340.0 nM
COc1ccc(C(C)(O)CN(C)N)cc1 CHEMBL1241430 pIC50 346.74 nM
C[C@@H]([C@H](O)c1ccccc1)N(C)N CHEMBL1241262 pIC50 346.74 nM
CC(C)CN(N)CC(O)c1ccccc1 CHEMBL1241261 pIC50 346.74 nM
COc1ccc(CCN(C)N)cc1OC CHEMBL1240956 pIC50 346.74 nM
COc1ccccc1CCN(C)N CHEMBL1240911 pIC50 346.74 nM
CN(C)C(=O)c1ccc(OC/C(F)=C\CN)cc1 CHEMBL2029542 IC50 370.0 nM
COc1ccc(OC)c(CCN(C)N)c1 CHEMBL1240955 pIC50 371.54 nM
COc1ccc(C(CN(C)N)OCc2ccccc2)cc1 CHEMBL1243019 pIC50 389.05 nM
CC(=O)Nc1cc(-c2ccc(S(C)(=O)=O)cc2)n(CCc2ccc(NC(=N)N)cc2)n1 CHEMBL2376168 IC50 390.0 nM
COC(CN(C)N)c1cccc2ccccc12 CHEMBL1241377 pIC50 398.11 nM
Cc1nc(N2CCOCC2)ncc1-c1cccc(COC(=O)NC(=N)N)c1F CHEMBL4082470 IC50 400.0 nM
COc1cccc(C(CN(C)N)OC)c1 CHEMBL1241331 pIC50 407.38 nM
COC(CN(C)N)c1cccc(Cl)c1 CHEMBL1241293 pIC50 407.38 nM
Cc1c(COC(=O)NC(=N)N)cccc1-c1cnc(N2CCOCC2)nc1 CHEMBL4064461 IC50 410.0 nM
COc1ccc(C(CN(C)N)OC)cc1 CHEMBL1241332 pIC50 416.87 nM
CN(Cc1cccc(-c2ccc(C(=O)N3CCOCC3)cc2)c1)C(=O)CN CHEMBL3949944 IC50 420.0 nM
COC(CN(C)N)c1ccc(Cl)cc1 CHEMBL1241329 pIC50 426.58 nM
CN(N)CC(O)c1ccc2ccccc2c1 CHEMBL1241260 pIC50 426.58 nM
COC(CN(C)N)c1cccc(F)c1 CHEMBL1241291 pIC50 436.52 nM
CC(C)CN(N)CCc1ccccc1 CHEMBL1241067 pIC50 436.52 nM
CNc1cncc(N(C)C)c1CN CHEMBL534467 IC50 440.0 nM
CC(=O)Nc1ccc(-c2cccc(CN(C)C(=O)CN)c2)cc1 CHEMBL3913195 IC50 460.0 nM
CC(CN(C)N)c1ccccc1 CHEMBL1241429 pIC50 467.74 nM
CCN(CC)Cc1ccc(-c2cccc(CN(C)C(=O)CN)c2)cc1 CHEMBL3932184 IC50 480.0 nM
CC(C)C(=O)Nc1nc(CCc2ccc(NC(=N)N)cc2)cs1 CHEMBL2326870 IC50 520.0 nM
CN(Cc1cccc(-c2cnc(N3CCOCC3)nc2)c1)C(=O)NC(=N)N CHEMBL4093809 IC50 530.0 nM
CCN(CC)C(=O)c1ccc(-c2cccc(CN(C)C(=O)CN)c2)cc1 CHEMBL3922197 IC50 560.0 nM
CN(N)C(C)(C)C(O)c1ccccc1 CHEMBL1241290 pIC50 562.34 nM
COC(CN(C)N)c1ccc(F)cc1 CHEMBL1241292 pIC50 575.44 nM
N=C(N)NC(=O)OCc1cccc(-c2cnc(N3CCOCC3)nc2)c1Cl CHEMBL4097484 IC50 600.0 nM
CCNC(=O)c1ccc(-c2cccc(CN(C)C(=O)CN)c2)cc1 CHEMBL3917228 IC50 610.0 nM
COc1ccc(C(CN(C)N)OC)c(OC)c1OC CHEMBL1241376 pIC50 630.96 nM
CCNC(=N)Nc1ccc(CCc2csc(NC(C)=O)n2)cc1 CHEMBL2326861 IC50 680.0 nM
CC(=O)Nc1nc(CCc2ccc(NC=N)cc2)cs1 CHEMBL2326865 IC50 730.0 nM
CN(Cc1cccc(-c2ccccc2)c1)C(=O)CN CHEMBL3948293 IC50 800.0 nM