Cc1ccc(C2(O)C(=O)c3ccccc3C2=O)c(O)c1C CHEMBL1344064 Potency 0.0251 nM
O=C1CCCc2oc3ccc(NS(=O)(=O)c4cccc5cccnc45)cc3c21 CHEMBL1386550 Potency 0.0708 nM
NC(=O)c1ccc2nc(NC(=O)c3ccc(N)cc3)sc2c1 CHEMBL1578798 Potency 0.2 nM
COc1cc([N+](=O)[O-])cc(/C=N/NC(=O)CC#N)c1O CHEMBL1091723 Potency 0.7 nM
Cc1coc2c1C(=O)C(=O)c1c-2ccc2c1CCCC2(C)C CHEMBL187266 Kd 0.88 nM
O=C1C2CC=C(Cl)CC2C(=O)N1c1nc[nH]n1 CHEMBL1323786 Potency 1.1 nM
Cc1nnc(SCC(=O)NC(=O)NCc2ccco2)n1Cc1ccccc1 CHEMBL1566820 Potency 1.3 nM
C=C(C)C(=O)OCCCCCCOc1ccc(C(=O)O)cc1 CHEMBL1305422 Potency 1.3 nM
COc1ccc(/C=N/NC(=O)COc2cccc3cccnc23)cc1OC CHEMBL3210521 Potency 1.4 nM
O=[N+]([O-])c1ccc(/C(O)=C(/C([S-])=NCc2ccco2)[n+]2ccccc2)cc1 CHEMBL1432717 Potency 1.4 nM
CCCCCCCCC/C(=C\C1=C(C)C(=O)C(OC)=C(OC)C1=O)C(=O)O CHEMBL578390 Kd 1.6 nM
CCCCC#Cc1ccccc1CC(=O)Nc1ccccc1 CHEMBL1410367 Potency 1.8 nM
Cc1cc(C(=O)N/N=C/c2ccc(O)c(O)c2O)c(C)n1-c1ccccc1 CHEMBL3197141 Potency 2.0 nM
C/N=c1\scc(-c2ccccc2F)n1/N=C/c1ccc[nH]1 CHEMBL1971760 Potency 2.2 nM
O=C(O)C[C@@H]1C(=O)O[C@@H]2C(COC(=O)c3cc(O)c(O)c(O)c3)O[C@@H](OC(=O)c3cc(O)c(O)c(O)c3)[C@@H](OC(=O)c3cc(O)c(O)c4c3[C@H]1[C@H](O)C(=O)O4)[C@H]2OC(=O)c1cc(O)c(O)c(O)c1 CHEMBL1391063 Potency 2.2 nM
COc1ccccc1C1CN(c2ccccc2)N=C1c1cccs1 CHEMBL1611306 Potency 2.5 nM
Cc1c(-c2ccc(Cl)cc2)oc(=O)c2c(N)n(-c3ccccc3)nc12 CHEMBL1465659 Potency 2.5 nM
O=C(CSc1nnnn1-c1ccccc1)NC(=O)NCc1ccco1 CHEMBL1321148 Potency 2.8 nM
Nc1cc([N+](=O)[O-])ccc1N1C(=O)CCCC1=O CHEMBL1409844 Potency 3.5 nM
CCN(CC)Cc1cc(O)c(CN(CC)CC)cc1O CHEMBL1451059 Potency 3.5 nM
COc1ccc(/C(C)=N/Nc2ccccc2Cl)c(O)c1 CHEMBL1994685 Potency 4.5 nM
O=C(OCC1O[C@@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@@H]1OC(=O)c1cc(O)c(O)c(O)c1)c1cc(O)c(O)c(O)c1 CHEMBL1500249 Potency 6.3 nM
CN1CCN2c3ccc(N)cc3CC3(C(=O)NC(=O)NC3=O)C2C1 CHEMBL1441170 Potency 6.3 nM
COc1ccc(-n2nc3c(=O)[nH][nH]c3cc2=O)cc1 CHEMBL3145010 Potency 7.9 nM
CC1=NOC(=O)/C1=C\c1ccc(-c2ccc(Cl)c(C(=O)O)c2)o1 CHEMBL1538023 Potency 10.0 nM
O=C(O)c1ccc2[nH]cc(CCCCN3CC=C(c4ccccc4)CC3)c2c1 CHEMBL1610567 Potency 10.0 nM
CCN(CC)CCNc1ccc(CO)c2sc3ccccc3c(=O)c12 CHEMBL22077 Kd 10.0 nM
O=c1oc2c(O)c(O)cc3c(=O)oc4c(O)c(O)cc1c4c23 CHEMBL6246 Potency 14.1 nM
O=C1N/C(=C/c2ccco2)C(=O)N1Cc1ccccc1F CHEMBL1576814 Potency 15.8 nM
O=C1C2C3C=CC(CC3)C2C(=O)N1c1nccs1 CHEMBL1404357 Potency 28.2 nM
O=C(Cc1csc(N2CCOCC2)n1)N/N=C/c1ccc(O)c(O)c1O CHEMBL3196993 Potency 35.5 nM
COC(=O)[C@H]1[C@H]2C[C@H]3c4[nH]c5ccccc5c4CCN3C[C@H]2CC[C@@H]1O CHEMBL1257131 Potency 39.8 nM
CC1=[N+](C)c2ccc3ccccc3c2C1(C)C CHEMBL1358777 Potency 44.7 nM
O=S(=O)(O)c1ccc2c(c1)-c1nc-2nc2[nH]c(nc3nc(nc4[nH]c(n1)c1ccc(S(=O)(=O)O)cc41)-c1ccc(S(=O)(=O)O)cc1-3)c1ccc(S(=O)(=O)O)cc21 CHEMBL1331939 Potency 50.1 nM
O=C(O[C@@H]1OC2COC(=O)c3cc(O)c(O)c(O)c3-c3c(cc(O)c(O)c3O)C(=O)O[C@@H]([C@H]1O)[C@@H]2O)c1cc(O)c(O)c(O)c1 CHEMBL1425538 Potency 50.1 nM
O=C(O)C1=CC(=C(c2ccc(O)c(C(=O)O)c2)c2ccc(O)c(C(=O)O)c2)C=CC1=O CHEMBL275938 IC50 55.0 nM
c1cc2ccc3cc2cc1CNCCOCCNCc1ccc2ccc(cc2c1)CNCCOCCNC3 CHEMBL4210534 IC50 55.0 nM
c1cc2ccc3cc2cc1CNCCNCCNCc1ccc2ccc(cc2c1)CNCCNCCNC3 CHEMBL4205402 IC50 57.0 nM
N#Cc1ccccc1CN1C(=O)S/C(=C/c2cccn2-c2ccc(C(=O)O)cc2)C1=O CHEMBL1322274 Potency 63.1 nM
CCOC(=O)NC1(NC(C)C)Oc2ccccc2O1 CHEMBL1307297 Potency 63.1 nM
CCN(CC)CCNc1ccc(C)c2sc3ccccc3c(=O)c12 CHEMBL279014 Kd 89.0 nM
O=C(OC1Cc2c(O)cc(O)cc2OC1c1cc(O)c(O)c(O)c1)c1cc(O)c(O)c(O)c1 CHEMBL311663 Potency 89.1 nM
Cc1ncc(CO)c(/C=N/NC(=O)c2cc(O)c(O)c(O)c2)c1O CHEMBL3191714 Potency 100.0 nM
NC(Cc1cc(O)c(O)cc1O)C(=O)O CHEMBL109037 IC50 110.0 nM
O=c1oc2c(cc1O)oc(=O)c1cc(O)c(O)c(O)c12 CHEMBL1601846 Potency 125.9 nM
CCc1cc(=O)oc2cc(C)c(CN3CCCC3)c(O)c12 CHEMBL1419637 Potency 141.3 nM
O=C(O)c1cc2cc(F)ccc2[nH]1 CHEMBL23507 Potency 141.3 nM
NC(Cc1ccc(O)c(O)c1)C(=O)O CHEMBL351042 Potency 158.5 nM
O=C(OC1Cc2c(O)cc(O)cc2OC1c1cc(O)c(O)c(O)c1-c1c(C2Oc3cc(O)cc(O)c3CC2O)cc(O)c(O)c1O)c1cc(O)c(O)c(O)c1 CHEMBL1325390 Potency 177.8 nM
C=CCN1C(=O)NC(=O)/C(=C(/CC)NN=C(S)Nc2ccccc2)C1=O CHEMBL1525544 Potency 177.8 nM
N#C/C(=C\c1ccc(O)c(O)c1)C(=O)c1ccc(O)c(O)c1 CHEMBL56393 Potency 199.5 nM
Brc1cc(-c2cc(Br)c(Br)c(Br)c2)cc(Br)c1Br CHEMBL4217125 IC50 200.0 nM
Nc1c(S(=O)(=O)O)cc(Nc2ccc(Nc3nc(Cl)nc(Nc4ccc(S(=O)(=O)O)cc4)n3)c(S(=O)(=O)O)c2)c2c1C(=O)c1ccccc1C2=O CHEMBL1160025 IC50 250.0 nM
Nc1c(S(=O)(=O)[O-])cc(Nc2ccc(Nc3nc(Cl)nc(Nc4ccc(S(=O)(=O)[O-])cc4)n3)c(S(=O)(=O)[O-])c2)c2c1C(=O)c1ccccc1C2=O CHEMBL1365553 IC50 250.0 nM
CC(=O)Nc1ccc(/C=C/c2ccc(N=C=S)c(S(=O)(=O)[O-])c2)c(S(=O)(=O)[O-])c1 CHEMBL4205950 IC50 250.0 nM
COc1cc(N(C)C)cc(CN(C)CCc2ccc([N+](=O)[O-])cc2)c1O CHEMBL1553873 Potency 281.8 nM
COCc1cc(O)c(O)c(O)c1-c1c(COC)cc(O)c(O)c1O CHEMBL59451 Potency 316.2 nM
O=c1c(O)c(Br)ccc2c(Br)c(O)c(O)c(O)c12 CHEMBL1554829 Potency 316.2 nM
O=C(OC1Cc2c(O)cc(O)cc2OC1c1cc(O)c(O)c(O)c1-c1c(C2Oc3cc(O)cc(O)c3CC2OC(=O)c2cc(O)c(O)c(O)c2)cc(O)c(O)c1O)c1cc(O)c(O)c(O)c1 CHEMBL1394337 Potency 316.2 nM
NC(=O)c1oc2ccccc2c1NC(=O)c1nc2ccccc2s1 CHEMBL1323312 Potency 316.2 nM
O=c1c(O)c(-c2cc(O)c(O)c(O)c2)oc2cc(O)cc(O)c12 CHEMBL164 IC50 320.0 nM
C=C(C)C(=O)Nc1cccc(C2=NOC3(C2)C[C@H](C(N)=O)N(C(=O)COc2ccc(Cl)cc2)C3)c1 CHEMBL1509377 Potency 354.8 nM
O=c1c(-c2cc(O)c(O)c(O)c2)coc2cc(O)c(O)c(O)c12 CHEMBL1438439 Potency 398.1 nM
O=C1c2ccccc2C(=O)N1/N=C/c1ccc(O)c(O)c1O CHEMBL3189657 Potency 398.1 nM
Cc1ccc(S(=O)(=O)Nc2cc(O)nc(SCC(=O)Nc3ccccc3Cl)n2)cc1 CHEMBL1305518 Potency 398.1 nM
COc1ccc(C(=O)OCC(=O)NCc2ccco2)cc1OC CHEMBL1560245 Potency 398.1 nM
COc1cc2c(ccc3cc(OC)c(OC)c(O)c32)cc1O CHEMBL1346456 IC50 400.0 nM
Cc1nc(SCC(=O)O)c(C#N)c2c1CCCC2 CHEMBL1376492 Potency 446.7 nM
O=c1c(O)cccc2cc(O)c(O)c(O)c12 CHEMBL66953 Potency 446.7 nM
COc1c(O)cc2c(=O)oc3c(OC)c(O)cc4c(=O)oc1c2c34 CHEMBL487203 Potency 446.7 nM
CN(N=O)c1ccc(O)c(O)c1 CHEMBL1256623 IC50 500.0 nM
O=c1cc(-c2ccc(O)cc2)oc2c(O)c(O)c(O)c(O)c12 CHEMBL234338 Potency 501.2 nM
O=C(O)CCCCC1CCSS1 CHEMBL33864 Potency 501.2 nM
O=c1c(O)c(-c2ccc(O)c(O)c2)oc2c(O)c(O)cc(O)c12 CHEMBL253570 Potency 501.2 nM
C/C(CC(=O)Nc1cccc(Cl)c1Cl)=N\NC(=O)c1ccccc1C CHEMBL3191528 Potency 501.2 nM
NCCc1cc(O)c(O)cc1O CHEMBL337702 Potency 562.3 nM
Cc1ccc(CN2C(=O)N/C(=C\c3ccc(-c4ccc(C(=O)O)cc4C)o3)C2=O)cc1 CHEMBL1524942 Potency 562.3 nM
CC(N)(Cc1ccc(O)c(O)c1)C(=O)O CHEMBL718 Potency 562.3 nM
O=c1cc(-c2ccccc2)oc2cc(O)c(O)c(O)c12 CHEMBL8260 Potency 631.0 nM
O=C(/C=C/c1ccc(O)c(O)c1)O[C@H](Cc1ccc(O)c(O)c1)C(=O)O CHEMBL324842 Potency 631.0 nM
O=C(O)c1cc(O)c2c(c1)[C@H]([C@H]1c3cc(C(=O)O)cc(O)c3C(=O)c3c(O[C@@H]4OC(CO)C(O)C(O)C4O)cccc31)c1cccc(O[C@@H]3OC(CO)C(O)C(O)C3O)c1C2=O CHEMBL1314924 Potency 707.9 nM
COc1ccc2nc(N3CCCCC3)c(C#N)cc2c1 CHEMBL1560136 Potency 707.9 nM
Cc1sc2ncnc(SCC(=O)NC(=O)NCc3ccco3)c2c1C CHEMBL1386676 Potency 707.9 nM
NC[C@H](O)c1ccc(O)c(O)c1 CHEMBL1437 Potency 794.3 nM
CC1(C)CC(=O)C=C(NCc2ccccc2)C1 CHEMBL1495997 Potency 794.3 nM
O=c1cc(O)cc(/C=C/c2ccc(O)c(O)c2)o1 CHEMBL1224512 Potency 794.3 nM
CC(C)(C)c1ccc(OC(=O)c2sc3ccccc3c2Cl)c(C(C)(C)C)c1 CHEMBL4211672 IC50 800.0 nM
CC(C)(C)NC(=O)c1cc(F)c(F)cc1Cl CHEMBL1385364 Potency 891.3 nM
CCc1cc2c(=O)c(-c3nc4ccccc4n3C)coc2c(CN2CCN(C)CC2)c1O CHEMBL1416177 Potency 891.3 nM
O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)ccc12 CHEMBL31574 Potency 891.3 nM
NC(=O)C1CCN(C2CC(=O)NC2=O)CC1 CHEMBL1414095 Potency 891.3 nM
O=C(CN1CCN(S(=O)(=O)/C=C/c2ccccc2)CC1)NC(=O)NCc1ccco1 CHEMBL1353644 Potency 891.3 nM
CC(C(=O)O)N1C(=O)/C(=C/C=C/c2ccco2)SC1=S CHEMBL255881 Potency 891.3 nM
Cc1sc(Nc2cc(Cl)cc(Cl)c2)nc1-c1ccc(-c2ccccc2F)cc1 CHEMBL4203747 IC50 900.0 nM
COC1=C(/C=C(\C)C(=O)O)C(=O)c2ccccc2C1=O CHEMBL577297 IC50 1000.0 nM
CSC1=C(/C=C(\C)C(=O)O)C(=O)c2ccccc2C1=O CHEMBL572060 IC50 1000.0 nM
C/C(=C\C1=C(Cl)C(=O)c2ccccc2C1=O)C(=O)O CHEMBL568994 IC50 1000.0 nM
COCC/C(=C\C1=C(Br)C(=O)c2ccccc2C1=O)C(=O)O CHEMBL570293 IC50 1000.0 nM
C/C(=C\C1=C(Cl)C(=O)c2ccccc2C1=O)C(=O)NCCO CHEMBL570294 IC50 1000.0 nM
COc1cc(-c2ccc(/N=N\c3ccc4c(S(=O)(=O)O)cc(S(=O)(=O)O)c(N)c4c3O)c(OC)c2)ccc1/N=N\c1ccc2c(S(=O)(=O)O)cc(S(=O)(=O)O)c(N)c2c1O CHEMBL1368261 Potency 1000.0 nM
CCn1c(CSc2nc3ccccc3s2)nnc1SCC(=O)c1ccc(O)c(O)c1 CHEMBL1526624 Potency 1000.0 nM
Cc1cc2c3c(cccc3n1)C(=O)c1ccccc1-2 CHEMBL1364100 Potency 1000.0 nM
O=C(CSc1nc2cc(Cl)c(Cl)cc2[nH]1)c1ccc2c(c1)OCO2 CHEMBL1412621 Potency 1000.0 nM
C=C/C(C)=C/[C@@]1(C)SC(=O)C(C)=C1O CHEMBL399043 Potency 1000.0 nM
CN(C(=O)Cc1ccc(Cl)c(Cl)c1)[C@@H]1CCCC[C@@H]1N1CCCC1 CHEMBL1357760 Potency 1000.0 nM
CC(=O)Nc1sc2c(c1-c1nc3ccccc3s1)CNC2 CHEMBL1706858 IC50 1000.0 nM