COc1cc(/C=C/C(O)=C/C(=O)/C=C/c2ccc(OCCCF)c(OC)c2)ccc1O CHEMBL384465 Ki 0.07 nM
O=C(O)c1cc(/C=C/c2ccc(/C=C/c3ccc(O)c(C(=O)O)c3)c(Br)c2)ccc1O CHEMBL74704 Ki 0.11 nM
O=C(O)c1cc(/C=C\c2ccc(/C=C\c3ccc(O)c(C(=O)O)c3)c(Br)c2)ccc1O CHEMBL76112 Ki 0.13 nM
O=C(O)c1cc(/N=N/c2ccc(-c3ccc(/N=N/c4ccc(O)c(C(=O)O)c4)cc3)cc2)ccc1O CHEMBL300172 Ki 0.14 nM
COc1ccc(/C=C/c2ccc(/C=C/c3ccc(OC)c(C(=O)O)c3)c(I)c2)cc1C(=O)O CHEMBL292910 Ki 0.17 nM
O=C(O)c1cc(/C=C\c2ccc(/C=C/c3ccc(O)c(C(=O)O)c3)cc2Br)ccc1O CHEMBL305634 Ki 0.19 nM
CNc1ccc(-c2nc3ccc(F)cc3s2)cc1 CHEMBL1774642 Ki 0.2 nM
COc1cc(/C=C/C(=O)/C=C(O)/C=C/c2ccc(O)c(OC)c2)ccc1O CHEMBL116438 Ki 0.208 nM
CN1C(=O)c2ccc(Nc3ccc([125I])cc3)cc2C1=O CHEMBL607562 Kd 0.21 nM
O=C(O)c1cc(/C=C\c2ccc(/C=C/c3ccc(O)c(C(=O)O)c3)c(Br)c2)ccc1O CHEMBL74348 Ki 0.27 nM
O=C(OC1([C@H]2CCC[C@@H](c3cc(F)cc(F)c3)N2S(=O)(=O)c2ccc(Cl)cc2)CC1)N1CCC(N2CCCCC2)CC1 CHEMBL240055 IC50 0.3 nM
CN(C)c1ccc(-c2nc3ccc(F)cc3s2)cc1 CHEMBL1774643 Ki 0.3 nM
COc1ccc(OCc2ccc([125I])cc2)cc1 CHEMBL3314344 Kd 0.56 nM
CO[C@H]1CC[C@]2(CC1)Cc1ccc(OCCC(F)(F)F)cc1C21N=C(C)C(N)=N1 CHEMBL3959097 IC50 0.6 nM
O=S(=O)(NC1CCC(c2cc(F)ccc2F)(S(=O)(=O)c2ccc(Cl)cc2)CC1)C(F)(F)F CHEMBL1091513 IC50 0.65 nM
CNc1ccc(-c2cc3cc(O)ccc3o2)cc1 CHEMBL204829 Ki 0.7 nM
CNc1ccc(-c2nc3ccc(O)cc3s2)cc1[18F] CHEMBL2042122 Ki 0.7 nM
CO[C@H]1CC[C@]2(CC1)Cc1ccc(OCCC(F)(F)F)cc1[C@@]21N=C(C)C(N)=N1 CHEMBL3898248 IC50 0.7 nM
CO[C@H]1CC[C@]2(CC1)Cc1ccc(C#CC(C)C)cc1[C@]21N=C(C)C(N)=N1 CHEMBL4110988 IC50 0.7 nM
CNc1ccc(-c2nc3ccc(O)cc3s2)cc1F CHEMBL579205 Ki 0.74 nM
CN(C)c1ccc(-c2nc3ccc(Br)cc3s2)cc1 CHEMBL55401 Ki 0.8 nM
[11CH3]Nc1ccc(-c2nc3ccc(O)cc3s2)cc1 CHEMBL207456 Ki 0.8 nM
CO[C@H]1CC[C@]2(CC1)Cc1cc(F)c(-c3cc(Cl)cc(C#N)c3)cc1[C@@]21N=C(C)C(N)=N1 CHEMBL3902640 IC50 0.8 nM
CO[C@H]1CC[C@]2(CC1)Cc1ccc(OCCC3CC3)cc1C21N=C(C)C(N)=N1 CHEMBL3939963 IC50 0.8 nM
CNc1ccc(-c2nc3ccc(O)cc3s2)cc1 CHEMBL93124 Ki 0.87 nM
CN(C)c1ccc(-c2cnc3cc(OCC[18F])ccc3n2)cc1 CHEMBL2407622 Ki 0.895 nM
CN(C)c1ccc(-c2cnc3cc(OCCF)ccc3n2)cc1 CHEMBL2407616 Ki 0.895 nM
CN(C)c1ccc(-c2nc3ccc(I)cc3s2)cc1 CHEMBL55380 Ki 0.9 nM
CN1C(=O)c2ccc(Nc3ccc(I)cc3)cc2C1=O CHEMBL610504 Ki 0.9 nM
CO[C@H]1CC[C@]2(CC1)Cc1ccc(OCC3CC3)cc1[C@@]21N=C(C)C(N)=N1 CHEMBL3937398 IC50 0.9 nM
CCS(=O)(=O)NC[C@@H]1CCC[C@@]2(S(=O)(=O)c3ccc(Cl)cc3)c3c(F)ccc(F)c3OC[C@@H]12 CHEMBL1086286 IC50 1.0 nM
CC#Cc1cncc(-c2ccc3c(c2)[C@@]2(N=C(C)C(N)=N2)[C@]2(CC[C@H](O)CC2)C3)c1 CHEMBL3653726 IC50 1.0 nM
COc1cc(C#N)cc(-c2ccc3c(c2)C2(N=C(C)C(N)=N2)[C@]2(CC3)CC[C@@H](OC)CC2)c1 CHEMBL3672723 IC50 1.0 nM
C[C@@]1(c2cc(NC(=O)c3ccc(C#N)cn3)ccc2F)Cn2nc(C#N)cc2C(N)=N1 CHEMBL5084378 IC50 1.0 nM
C[C@@]1(c2cc(NC(=O)c3ccc(OC(F)F)cn3)ccc2F)Cn2nc(C#N)cc2C(N)=N1 CHEMBL5093303 IC50 1.0 nM
CN(C)c1ccc(/C=C/c2ccc(O)cc2)cc1 CHEMBL198598 Ki 1.1 nM
CNc1ccc(/C=C/c2ccc(O)cc2)cc1 CHEMBL381642 Ki 1.2 nM
CNc1ccc(C#Cc2ccc(OCCOCCF)cc2)cc1 CHEMBL227521 Ki 1.2 nM
C[C@@]1(c2cc(NC(=O)c3cnc(OCF)cn3)ccc2F)Cn2nc(C#N)cc2C(N)=N1 CHEMBL5082406 IC50 1.2 nM
CNc1ccc(-c2nc3ccccc3s2)cc1 CHEMBL93334 Ki 1.28 nM
CN(C)c1ccc(-c2cn3cc(I)ccc3n2)cc1 CHEMBL78012 Ki 1.29 nM
CNc1ccc(-c2cc3cc(OC)ccc3o2)cc1 CHEMBL208212 Ki 1.3 nM
CO[C@H]1CC[C@]2(CC1)Cc1ccc(OCC3CCC3)cc1[C@@]21N=C(C)C(N)=N1 CHEMBL3927449 IC50 1.3 nM
COc1cnc(C(=O)Nc2ccc(F)c([C@]3(C)Cn4nc(C#N)cc4C(N)=N3)c2)cn1 CHEMBL5074068 IC50 1.3 nM
CCCC[N+]1=C(/C=C/c2ccc(N(CC)CC)cc2)C(C)(C)c2ccccc21 CHEMBL2203332 Ki 1.37 nM
O=S(=O)(CC[C@@H]1OCC[C@@]2(S(=O)(=O)c3ccc(Cl)cc3)c3c(F)ccc(F)c3OCC12)CCn1cccn1 CHEMBL3943313 IC50 1.4 nM
CNc1ccc(C#Cc2ccc(O)cc2)cc1 CHEMBL228033 Ki 1.5 nM
FCCOCCOCCOc1ccc(C#Cc2ccc3[nH]ccc3c2)cc1 CHEMBL519255 Ki 1.5 nM
CO[C@H]1CC[C@]2(CC1)Cc1ccc(OCC3CCC3)cc1C21N=C(C)C(N)=N1 CHEMBL3961886 IC50 1.5 nM
CN(C)c1ncc(/C=C/c2nc3cc(OCCF)ccc3[se]2)cn1 CHEMBL5207165 Kd 1.58 nM
CN1CCN(c2ccc(-c3nc4ccc(Br)cc4s3)cc2)CC1 CHEMBL55536 Ki 1.6 nM
CNc1ccc(C#Cc2cnc(OCCO)c(Br)c2)cc1 CHEMBL232112 Ki 1.6 nM
CO[C@H]1CC[C@]2(CC1)Cc1ccc(C#CC(C)C)cc1[C@@]21N=C(C)C(N)=N1 CHEMBL3893021 IC50 1.6 nM
CC1=N[C@]2(N=C1N)c1cc(-c3cc(Cl)cc(C#N)c3)ccc1C[C@]21CC[C@@H](O)CC1 CHEMBL3672698 IC50 1.6 nM
CC1=N[C@]2(N=C1N)c1cc(OCCCF)ccc1C[C@]21CC[C@@H](OC(F)F)CC1 CHEMBL3672695 IC50 1.6 nM
CO[C@H]1CC[C@]2(CC1)Cc1ccc(OCC3CC3)cc1C21N=C(C)C(N)=N1 CHEMBL3923244 IC50 1.6 nM
CNc1ccc(-c2nc3ccc(Br)cc3s2)cc1 CHEMBL328660 Ki 1.7 nM
CNc1ccc(-c2nc3ccc(O)cc3s2)cn1 CHEMBL570378 Ki 1.7 nM
CO[C@H]1CC[C@]2(CC1)Cc1cc(F)c(-c3cc(Cl)cc(C#N)c3)cc1C21N=C(C)C(N)=N1 CHEMBL3947671 IC50 1.7 nM
O=S(=O)(CC[C@@H]1OCC[C@@]2(S(=O)(=O)c3ccc(Cl)cc3)c3c(F)ccc(F)c3OCC12)Cc1ncon1 CHEMBL3956918 IC50 1.7 nM
COc1ccc2nc(-c3ccc(N(C)C)cc3)sc2c1 CHEMBL328430 Ki 1.9 nM
CNc1ccc(C#Cc2ccc(OCCOCCOCCF)cc2)cc1 CHEMBL227495 Ki 1.9 nM
O=S(=O)(CC[C@@H]1OCC[C@@]2(S(=O)(=O)c3ccc(Cl)cc3)c3c(F)ccc(F)c3OCC12)Cc1ccccn1 CHEMBL3934479 IC50 1.9 nM
CN(C)c1ccc(/C=C/c2ccc(I)cc2)cc1 CHEMBL570610 Ki 2.0 nM
CO[C@H]1CC[C@]2(CC1)Cc1ccc(C#CC3CCC3)cc1[C@]21N=C(C)C(N)=N1 CHEMBL4112651 IC50 2.0 nM
N#CC(C#N)=C/C=C/C=C/c1ccc2c(ccn2Cc2ccccc2)c1 CHEMBL5420714 Ki 2.0 nM
CNc1ccc(-c2cn3c(n2)sc2cc(OCC[18F])ccc23)cc1 CHEMBL2017621 Ki 2.1 nM
CO[C@H]1CC[C@]2(CC1)Cc1ccc(C#CC3CCC3)cc1[C@@]21N=C(C)C(N)=N1 CHEMBL3891777 IC50 2.1 nM
COc1ccc2nc(-c3ccc(F)cc3)sc2c1 CHEMBL490083 Ki 2.2 nM
CNc1ccc(/C=C/c2ccc(OCCOCCOCC[18F])cc2)cc1 CHEMBL566752 Ki 2.2 nM
CNc1ccc(/C=C/c2ccc(OCCCCCCF)cc2)cc1 CHEMBL566723 Ki 2.22 nM
COc1ccc2oc(-c3ccc(N)cc3)cc2c1 CHEMBL205221 Ki 2.3 nM
CN(C)c1ccc(/C=C/c2nc3ccccc3s2)cc1 CHEMBL565657 Ki 2.3 nM
CNc1ccc(-c2nc3ccc(O)cc3s2)c([18F])n1 CHEMBL2042123 Ki 2.3 nM
CO[C@H]1CC[C@]2(CC1)Cc1ccc(OCC3CC3(F)F)cc1C21N=C(C)C(N)=N1 CHEMBL3905816 IC50 2.3 nM
O=C(OC1([C@H]2CCC[C@@H](c3cc(F)cc(F)c3)N2S(=O)(=O)c2ccc(Cl)cc2)CC1)N1CCN(CCO)CC1 CHEMBL239629 IC50 2.4 nM
[3H]N(c1ccc(/C=C/c2ccc(O)cc2)cc1)C([3H])([3H])[3H] CHEMBL1788117 Kd 2.4 nM
CC1=NC2(N=C1N)c1cc(Br)ccc1C[C@]21CC[C@@H](O)CC1 CHEMBL3672687 IC50 2.4 nM
CC#Cc1cncc(-c2ccc3c(c2)C2(N=C(C)C(N)=N2)[C@]2(CC3)CC[C@@H](OC)CC2)c1 CHEMBL3672728 IC50 2.4 nM
CCC[C@@H]1CCC[C@H](C2(OC(=O)N3CCC(N4CCCCC4)CC3)CC2)N1S(=O)(=O)c1ccc(Cl)cc1 CHEMBL239858 IC50 2.5 nM
CO[C@H]1CC[C@]2(CC1)Cc1ccc(OCC(C)F)cc1C21N=C(C)C(N)=N1 CHEMBL3899321 IC50 2.5 nM
CO[C@H]1CC[C@@]2(CCc3ccc(-c4cncc(Cl)c4)cc3C23N=C(C)C(N)=N3)CC1 CHEMBL3672725 IC50 2.5 nM
C[C@@]1(c2cc(NC(=O)c3cnc(C(F)F)cn3)ccc2F)Cn2nc(C#N)cc2C(N)=N1 CHEMBL5077699 IC50 2.5 nM
C[C@@]1(c2cc(NC(=O)c3ccc(F)cn3)ccc2F)Cn2nc(C#N)cc2C(N)=N1 CHEMBL5085412 IC50 2.6 nM
[3H]N(c1ccc(-c2nc3ccc(O)cc3s2)cc1)C([3H])([3H])[3H] CHEMBL1788111 Ki 2.8 nM
CN(C)c1ccc(-c2cc3cc(O)ccc3o2)cc1 CHEMBL204414 Ki 2.8 nM
O=C(OC1([C@H]2CCC[C@@H](C3CC3)N2S(=O)(=O)c2ccc(Cl)cc2)CC1)N1CCC(N2CCCCC2)CC1 CHEMBL400420 IC50 2.8 nM
CO[C@H]1CC[C@]2(CC1)Cc1ccc(OCC3(C)CC3)cc1C21N=C(C)C(N)=N1 CHEMBL3915935 IC50 2.8 nM
O=c1[nH]cccc1S(=O)(=O)CC[C@@H]1OCC[C@@]2(S(=O)(=O)c3ccc(Cl)cc3)c3c(F)ccc(F)c3OCC12 CHEMBL3941787 IC50 2.8 nM
CNc1ccc(/C=C/c2ccc(OCCOCCOCC[18F])nc2)cc1 CHEMBL1774461 Ki 2.87 nM
CN(C)c1ccc(C#Cc2ccc(OCCOCCOCCF)cc2)cc1 CHEMBL224096 Ki 2.9 nM
COc1ccc(C#Cc2ccc(N)cc2)cc1 CHEMBL223285 Ki 2.9 nM
COc1ccc(C#Cc2ccc(O)cc2)cc1 CHEMBL228034 Ki 2.9 nM
CNc1ccc(/C=C/c2ccc(OCCCCF)cc2)cc1 CHEMBL566709 Ki 2.9 nM
O=S(=O)(CC[C@@H]1OCC[C@@]2(S(=O)(=O)c3ccc(Cl)cc3)c3c(F)ccc(F)c3OCC12)c1ccncn1 CHEMBL3900140 IC50 2.9 nM
CO[C@H]1CC[C@]2(CC1)Cc1cc(F)c(-c3cncc(Cl)c3)cc1C21N=C(C)C(N)=N1 CHEMBL3969309 IC50 3.0 nM
Cc1cc(C#N)cnc1C(=O)Nc1ccc(F)c([C@]2(C)CO[C@@](C)(C(F)(F)F)C(N)=N2)n1 CHEMBL3261069 IC50 3.0 nM
C[C@@]1(c2nc(NC(=O)c3ncc(C#N)cc3Cl)ccc2F)CO[C@@](C)(C(F)(F)F)C(N)=N1 CHEMBL3670365 IC50 3.0 nM
C[C@@]1(c2nc(NC(=O)c3ncc(C(F)(F)F)cc3Cl)ccc2F)CO[C@@](C)(C(F)(F)F)C(N)=N1 CHEMBL3670375 IC50 3.0 nM
CC1(c2cc(NC(=O)c3ccc(Br)cn3)ccc2F)COCC(N)=N1 CHEMBL3653393 IC50 3.0 nM
Cc1cc(C#N)cnc1C(=O)Nc1ccc(F)c([C@]2(C)CO[C@@](C)(C(F)(F)F)C(N)=N2)c1 CHEMBL3261067 IC50 3.0 nM
Oc1ccc(-c2cc3ccccc3s2)cc1 CHEMBL4167943 Ki 3.04 nM
CNc1ccc(C#Cc2ccc(OCCOCCO)cc2)cc1 CHEMBL227577 Ki 3.1 nM
COC1CCC2(CCc3ccc(-c4cc(Cl)cc(C#N)c4)cc3C23N=C(C)C(N)=N3)CC1 CHEMBL3672730 IC50 3.1 nM
CC[C@@H]1CCC[C@H](C2(OC(=O)N3CCC(O)(CC)CC3)CC2)N1S(=O)(=O)c1ccc(Cl)cc1 CHEMBL392144 IC50 3.2 nM
CN(C)c1ccc(/C=C/C2=CC(/C=C/c3ccc(N(C)C)cc3)=[O+][B-]3(OC(=O)C(=O)O3)O2)cc1 CHEMBL5186511 Kd 3.2 nM
CNc1ccc(/C=C/c2ccc(OCCOCCOCCOCCOCC(COCCOCCOCCOCCOc3ccc(/C=C/c4ccc(NC)cc4)cn3)OCCF)nc2)cc1 CHEMBL2042124 Ki 3.24 nM
C[C@@]1(c2cc(NC(=O)c3ccc(C#N)cn3)ccc2F)Cn2c(C#N)cnc2C(N)=N1 CHEMBL2152899 IC50 3.3 nM
CN(C)c1ccc(C#Cc2ccc(OCCOCCOCCO)cc2)cc1 CHEMBL413436 Ki 3.4 nM
O=C(OC1([C@H]2CCC[C@@H](CC(F)(F)F)N2S(=O)(=O)c2ccc(Cl)cc2)CC1)N1CCC(N2CCCCC2)CC1 CHEMBL442801 IC50 3.5 nM
CC[C@@H]1CCC[C@H](C2(OC(=O)N3CCC(N4CCCCC4)CC3)CC2)N1S(=O)(=O)c1ccc(Cl)cc1 CHEMBL239859 IC50 3.5 nM
CC[C@@H]1CCC[C@H](C2(OC(=O)N3CC4CCC(C3)N4CCO)CC2)N1S(=O)(=O)c1ccc(Cl)cc1 CHEMBL392060 IC50 3.5 nM
CNc1ccc(-c2cn3c(n2)sc2cc(OC)ccc23)cc1 CHEMBL1671878 Ki 3.5 nM
CN(C)c1ccc(/C=C/c2cnc(OCCO)c(Br)c2)cc1 CHEMBL390561 Ki 3.6 nM
C[C@@]1(c2cc(NC(=O)c3ccc(Cl)cn3)ccc2F)Cn2c(C#N)cnc2C(N)=N1 CHEMBL5075933 IC50 3.6 nM
CN(C)c1ccc(C#Cc2ccc(OCCOCCO)cc2)cc1 CHEMBL389671 Ki 3.8 nM
CN(C)c1ccc2nc(-c3ccc(F)cc3)sc2c1 CHEMBL566354 Ki 3.8 nM
CN1C(=O)c2ccc(Nc3ccc(Br)cc3)cc2C1=O CHEMBL598081 Ki 3.8 nM
CNc1ccc(/C=C/c2ccc(OCCOCCOCCOCCOCCOCCOCC(COCCOCCOCCOCCOCCOCCOc3ccc(/C=C/c4ccc(NC)cc4)cn3)OCCF)nc2)cc1 CHEMBL2042245 Ki 3.86 nM
Oc1ccc(-c2ccc(-c3ccc(NCCF)cc3)s2)cc1 CHEMBL206224 Ki 3.9 nM
CN(C)c1ccc(-c2nnc(-c3ccc(I)cc3)o2)cc1 CHEMBL609015 Ki 3.91 nM
CN(C)c1ccc(-c2nc3ccccc3s2)cc1 CHEMBL92816 Ki 4.0 nM
Oc1ccc(-c2ccc(-c3ccc(O)cc3)s2)cc1 CHEMBL204010 Ki 4.0 nM
FCCOCCOCCOc1ccc(C#Cc2ccc3c(c2)CCN3)cc1 CHEMBL451807 Ki 4.0 nM
CN(C)c1ccc(-c2nc3ccc(F)nc3o2)cc1 CHEMBL2203379 IC50 4.0 nM
C[C@@]1(c2cccc(NC(=O)c3ccc(Br)cn3)c2)CCSC(N)=N1 CHEMBL5093426 IC50 4.0 nM
C[C@@]1(c2cc(NC(=O)c3ncc(C#N)cc3Cl)ccc2F)CO[C@@](C)(C(F)(F)F)C(N)=N1 CHEMBL5073160 IC50 4.0 nM
C[C@@]1(c2cc(NC(=O)c3ncc(C#N)cc3N)ccc2F)CO[C@@](C)(C(F)(F)F)C(N)=N1 CHEMBL5090563 IC50 4.0 nM
CNc1ccc2nc(-c3ccc(F)cc3)sc2c1 CHEMBL578982 Ki 4.1 nM
Cc1ccc(Nc2ccc3c(c2)C(=O)N(C)C3=O)cc1 CHEMBL598288 Ki 4.1 nM
COc1nc(-c2cc(C)c(N[C@@H](C)c3cc(F)cc(F)c3)nn2)ccc1-n1cnc(C)c1 CHEMBL5192892 IC50 4.1 nM
Nc1ccc(-c2cc3ccccc3s2)cc1 CHEMBL4175800 Ki 4.31 nM
COc1ccc2nc(/N=C/c3ccc(N(C)C)cc3)sc2c1 CHEMBL2296467 Ki 4.38 nM
CN(C)c1ccc(-c2nc3ccc(O)cc3s2)cc1 CHEMBL91449 Ki 4.4 nM
CNc1ccc(/C=C/c2ccc(OCCCCCCCCF)cc2)cc1 CHEMBL566296 Ki 4.4 nM
CNc1ccc(/C=C/c2cnc(OCCOCCOCCF)c(Br)c2)cc1 CHEMBL227921 Ki 4.5 nM
CNc1ccc(C#Cc2ccc(OCCOCCOCCO)cc2)cc1 CHEMBL227674 Ki 4.5 nM
CN(C)c1ccc(/C=C/c2cccc(I)c2)cc1 CHEMBL567746 Ki 4.5 nM
[3H]C([3H])([3H])N(C)c1ccc(-c2nc3ccc(F)nc3o2)cc1 CHEMBL2203393 Kd 4.5 nM
CO[C@H]1CC[C@]2(CCc3ccc(-c4cc(Cl)cc(C#N)c4)cc3C23N=C(C)C(N)=N3)CC1 CHEMBL3672732 IC50 4.5 nM
O=S(=O)(CC[C@@H]1OCC[C@@]2(S(=O)(=O)c3ccc(Cl)cc3)c3c(F)ccc(F)c3OCC12)c1cccnn1 CHEMBL3948649 IC50 4.5 nM
CO[C@H]1CC[C@]2(CC1)Cc1cc(F)c(-c3cc(F)cc(C#N)c3)cc1C21N=C(C)C(N)=N1 CHEMBL3943188 IC50 4.8 nM
Cc1nc(C(=O)Nc2ccc(F)c([C@]3(C)Cn4nc(C#N)cc4C(N)=N3)c2)co1 CHEMBL5093195 IC50 4.8 nM
CNc1ccc(-c2nc3ccc(OC)cc3s2)cc1 CHEMBL94230 Ki 4.9 nM
CNc1ccc(/C=C/c2ccc(OCC(CO)C[18F])cc2)cc1 CHEMBL567747 Ki 5.0 nM
CNc1ccc(/C=C/c2cnc(OCCO)c(Br)c2)cc1 CHEMBL227817 Ki 5.0 nM
CN(C)c1ccc(C#Cc2ccc(OCCOCCF)cc2)cc1 CHEMBL227576 Ki 5.0 nM
CNc1ccc(/C=C/c2ccc(OCC(CO)CF)cc2)cc1 CHEMBL373236 Ki 5.0 nM
C[C@@]1(c2nc(NC(=O)c3ncc(C#N)cc3N)ccc2F)CO[C@@](C)(C(F)(F)F)C(N)=N1 CHEMBL3670368 IC50 5.0 nM
C[C@@]1(c2cc(NC(=O)c3ncc(Br)cn3)ccc2F)CO[C@@](C)(C(F)(F)F)C(N)=N1 CHEMBL3653404 IC50 5.0 nM
CCCN(CCC)C(=O)c1cccc(C(=O)N[C@@H](Cc2ccccc2)[C@@H](N)C[C@@H](C)C(=O)N[C@H](C(=O)NCc2ccccc2)C(C)C)c1 CHEMBL199946 IC50 5.2 nM
COc1nc(-c2cc(C)c(N[C@@H](C)c3cc(F)c(F)c(F)c3)nn2)ccc1-n1cnc(C)c1 CHEMBL5206552 IC50 5.3 nM
CN1CCN(c2ccc(-c3nc4ccc(I)cc4s3)cc2)CC1 CHEMBL58092 Ki 5.4 nM
CP1(=O)OCC[C@]2(CCC[C@@]3(S(=O)(=O)c4ccc(Cl)cc4)c4c(F)ccc(F)c4OC[C@@H]23)CO1 CHEMBL3629745 IC50 5.4 nM
O=S(=O)(CC[C@@H]1OCC[C@@]2(S(=O)(=O)c3ccc(Cl)cc3)c3c(F)ccc(F)c3OCC12)c1cnccn1 CHEMBL3904071 IC50 5.5 nM
COc1ccc(-c2ccc(-c3ccc(N)cc3)s2)cc1 CHEMBL203320 Ki 5.6 nM
Cc1ccc2nc(-c3ccc(F)cc3)sc2c1 CHEMBL510384 Ki 5.7 nM
Cc1nc(CS(=O)(=O)CC[C@@H]2OCC[C@@]3(S(=O)(=O)c4ccc(Cl)cc4)c4c(F)ccc(F)c4OCC23)no1 CHEMBL3957316 IC50 5.8 nM
CN(C)c1ccc(-c2cn3cc(Br)ccc3n2)cc1 CHEMBL81260 Ki 5.9 nM
CNc1ccc(/C=C/c2ccc(OCCCCCCCCCCF)cc2)cc1 CHEMBL570606 Ki 6.0 nM
CN(C)c1ccc(C#CC(=O)c2ccc(I)cc2)cc1 CHEMBL1643335 Ki 6.0 nM
COc1cc(/C=c2\sc3nc(-c4cccc(Cl)c4)cn3c2=O)cc(OC)c1O CHEMBL3286988 IC50 6.0 nM
Cc1cc(OC(F)F)cnc1C(=O)Nc1ccc(F)c([C@]2(C)CO[C@@](C)(C(F)(F)F)C(N)=N2)c1 CHEMBL5086270 IC50 6.0 nM
Nc1ccc(-c2ccc(-c3ccc(N)cc3)s2)cc1 CHEMBL382007 Ki 6.1 nM
COc1ccc(-c2ccc(-c3ccc(O)cc3)s2)cc1 CHEMBL381991 Ki 6.1 nM
OCCOc1ncc(C#Cc2ccc(O)cc2)cc1I CHEMBL232114 Ki 6.2 nM
COc1cnc(C(=O)Nc2ccc(F)c([C@]3(C)Cn4c(C#N)cnc4C(N)=N3)c2)cn1 CHEMBL5073381 IC50 6.3 nM
[3H]C([3H])([3H])n1ccc2cc(-c3nc4ccc(F)nc4o3)ccc21 CHEMBL2203394 Kd 6.4 nM
O=S(=O)(CC[C@@H]1OCC[C@@]2(S(=O)(=O)c3ccc(Cl)cc3)c3c(F)ccc(F)c3OCC12)c1ncccn1 CHEMBL3928118 IC50 6.4 nM
O=S(=O)(CC[C@@H]1OCC[C@@]2(S(=O)(=O)c3ccc(Cl)cc3)c3c(F)ccc(F)c3OCC12)Cc1cccnc1 CHEMBL3961972 IC50 6.6 nM
CN(C)c1ccc(C#Cc2cnc(OCCO)c(Br)c2)cc1 CHEMBL231917 Ki 6.7 nM
CN(C)c1ccc(/C=C/c2cnc(OCCOCCOCCF)c(Br)c2)cc1 CHEMBL227869 Ki 6.8 nM
OCCOc1ncc(/C=C\c2ccc(O)cc2)cc1Br CHEMBL1162947 Ki 6.8 nM
CNc1ccc(-c2nc3ccc(-c4nc5ccc(Cl)cc5s4)cc3s2)cc1 CHEMBL242130 Ki 6.8 nM
CN(C)c1ccc(/C=C2\Oc3ccc([125I])cc3C2=O)cc1 CHEMBL3785292 Ki 6.82 nM
CC[C@@H]1CCC[C@H](C2(OC(=O)N3CCC(N4CCCCC4)CC3)CC2)N1S(=O)(=O)c1ccc(F)c(F)c1 CHEMBL236190 IC50 6.9 nM
CC[C@@H]1CCC[C@H](C2(OC(=O)N3CCN(C(C)(C)CO)CC3)CC2)N1S(=O)(=O)c1ccc(Cl)cc1 CHEMBL236184 IC50 6.9 nM
CN(C)c1ccc(-c2nc3cc([125I])ccc3o2)cn1 CHEMBL4470128 Ki 6.9 nM
COc1ccc2nc(-c3ccc(N)cc3)sc2c1 CHEMBL92390 Ki 7.0 nM
COc1cc(/C=c2\sc3nc(-c4ccc(Cl)cc4)cn3c2=O)cc(OC)c1O CHEMBL3286982 IC50 7.0 nM
CC(=O)CC[C@@H]1OCC[C@@]2(S(=O)(=O)c3ccc(Cl)cc3)c3c(F)ccc(F)c3OC[C@@H]12 CHEMBL3659993 IC50 7.0 nM
Cc1cc(C#N)cnc1C(=O)Nc1ccc(F)c([C@@]2(C)N=C(N)OCC2(F)F)n1 CHEMBL4114267 IC50 7.0 nM
CC1(C)OC(N)=N[C@](C)(c2nc(NC(=O)c3ncc(C#N)cc3Cl)ccc2F)C1(F)F CHEMBL2386721 IC50 7.0 nM
Nc1ccc(-c2nc3ccc(Br)cc3s2)cc1 CHEMBL92852 Ki 7.2 nM
CNc1ccc(-c2cn3cc(Br)ccc3n2)cc1Br CHEMBL245208 Ki 7.4 nM
CO[C@H]1CC[C@]2(CC1)Cc1cc(F)c(-c3cc(F)cc(C#N)c3)cc1[C@@]21N=C(C)C(N)=N1 CHEMBL3916194 IC50 7.4 nM
CN(C)c1ccc(-c2ccc(-c3ccc(O)cc3)s2)cc1 CHEMBL377279 Ki 7.5 nM
CNc1ccc(/C=C/C=C/C=C/c2ccc(NC)cc2)cc1 CHEMBL208457 Ki 7.5 nM
CN(C)c1ccc(/C=C/c2cnc(OCCO)c(I)c2)cc1 CHEMBL224148 Ki 7.5 nM
CN(C)c1ccc(/C=C/c2cnc(OCCOCCOCCF)c(I)c2)cc1 CHEMBL227750 Ki 7.5 nM
CNc1ccc(/C=C/c2ccc(OCCCCCCCCCCCCF)cc2)cc1 CHEMBL576655 Ki 7.5 nM
CCOC(=O)CN1C(=O)/C(=C/c2ccc3c(c2)Sc2ccccc2N3C)SC1=S CHEMBL5197693 Kd 7.5 nM
CN(C)c1ccc(-c2cn3cc([N+](=O)[O-])ccc3n2)cc1 CHEMBL244757 Ki 7.6 nM
CN1C(=O)c2ccc(Nc3ccccc3)cc2C1=O CHEMBL610505 Ki 7.6 nM
CN(C)c1ccc(/C=C/c2ccccc2I)cc1 CHEMBL565623 Ki 7.7 nM
CNc1ccc(/C=C/c2ccc(OCCOCCOCCOCCOCCOCC(COCCOCCOCCOCCOCCOc3ccc(/C=C/c4ccc(NC)cc4)cn3)OCCF)nc2)cc1 CHEMBL2042125 Ki 7.71 nM
CSc1ccc2nc(-c3ccc(N(C)C)cc3)cn2c1 CHEMBL252766 Ki 7.93 nM
Cn1ccc2cc(-c3nc4ccc(F)nc4o3)ccc21 CHEMBL2203383 IC50 8.0 nM
O=S(=O)(N[C@@H]1CC[C@@]2(S(=O)(=O)c3ccc(Cl)cc3)c3c(F)ccc(F)c3OC[C@H]2C1)C1CC1 CHEMBL1090210 IC50 8.0 nM
C[C@]1(c2nc(NC(=O)c3ncc(C#N)cc3Cl)ccc2F)N=C(N)OCC1(F)F CHEMBL2386720 IC50 8.0 nM
CN(C)c1ccc(-c2cn3cc(C#N)ccc3n2)cc1 CHEMBL442269 Ki 8.2 nM
CNc1ccc(/C=C/c2ccc(OCCCCCCCCCCCCCCF)cc2)cc1 CHEMBL566917 Ki 8.2 nM
COc1ccc(CSc2ccc3nc(-c4ccc(N(C)C)cc4)cn3c2)cc1 CHEMBL388460 Ki 8.3 nM
CCSc1ccc2nc(-c3ccc(N(C)C)cc3)cn2c1 CHEMBL242194 Ki 8.3 nM
CO[C@H]1CC[C@]2(CC1)Cc1ccc(OCC3CC(F)(F)C3)cc1C21N=C(C)C(N)=N1 CHEMBL3891403 IC50 8.4 nM
CNc1ccc(/C=C/c2cnc(OCCO)c(I)c2)cc1 CHEMBL224149 Ki 8.5 nM
C[C@@]1(c2cc(NC(=O)c3ccc(C#N)cn3)ccc2F)Cn2cc(C#N)nc2C(N)=N1 CHEMBL5085521 IC50 8.5 nM
CNc1ccc(-c2nc3ccc(C#N)cc3s2)cc1 CHEMBL92802 Ki 8.6 nM
Nc1ccc(/C=C/C=C/C=C/c2ccc(N)cc2)cc1 CHEMBL208456 Ki 9.0 nM
Oc1ccc(/C=C/C=C/C=C/c2ccc(O)cc2)cc1 CHEMBL381731 Ki 9.0 nM
CNc1ccc(/C=C/c2cnc(OCCOCCOCCF)c(I)c2)cc1 CHEMBL224147 Ki 9.0 nM
CC[C@@H]1CCC[C@H](C2(OC(=O)N3CCC(CCO)(OC)CC3)CC2)N1S(=O)(=O)c1ccc(Cl)cc1 CHEMBL394132 IC50 9.0 nM
O=[N+]([O-])c1ccc(-c2nc3ccccc3s2)cc1 CHEMBL477841 Ki 9.0 nM
CNc1ccc(/C=C/c2ccc(OCCCCCCCCCCCCCCCCF)cc2)cc1 CHEMBL566711 Ki 9.0 nM
C[C@@]1(c2cc(NC(=O)c3ccc(C#N)cn3)ccc2F)CO[C@@](C)(C(F)(F)F)C(N)=N1 CHEMBL3653405 IC50 9.0 nM
C[C@@]1(c2cc(NC(=O)c3ncc(OC(F)F)cc3Cl)ccc2F)CO[C@@](C)(C(F)(F)F)C(N)=N1 CHEMBL5074449 IC50 9.0 nM
CN(C)c1ccc(/C=C2\COc3ccc(Br)cc3C2=O)cc1 CHEMBL3126514 Ki 9.1 nM
CN(C)c1ccc(C#Cc2cnc(OCCO)c(I)c2)cc1 CHEMBL231916 Ki 9.2 nM
COc1cc(/C=C/C(O)=C/C(=O)/C=C/c2cc(I)c(O)c(OC)c2)ccc1O CHEMBL215110 Ki 9.37 nM
Cc1ccc2nc(-c3ccc(N)cc3)sc2c1 CHEMBL93109 Ki 9.5 nM
C[P@]1(=O)OC[C@]2(CCC[C@@]3(S(=O)(=O)c4ccc(Cl)cc4)c4c(F)ccc(F)c4OC[C@@H]23)CO1 CHEMBL3899794 IC50 9.5 nM
Nc1ccc(-c2ccc(-c3ccc(O)cc3)s2)cc1 CHEMBL205824 Ki 9.6 nM
CC[C@@H]1CCC[C@H](C2(OC(=O)N3CCN(C(C)(C)CO)CC3)CC2)N1S(=O)(=O)c1ccc(F)c(F)c1 CHEMBL236188 IC50 9.6 nM
[3H]C([3H])([3H])n1ccc2cc(-c3nc4ccc(F)nc4o3)cnc21 CHEMBL2203395 Kd 9.6 nM
COc1ccc(/C=C2\COc3ccc(Br)cc3C2=O)cc1 CHEMBL3126511 Ki 9.98 nM
CNc1ccc(-c2nc3ccc(C)cc3s2)cc1 CHEMBL330529 Ki 10.0 nM
CC[C@@H]1CCC[C@H](C2(OC(=O)N3CCN(C(C)(C)CO)CC3)CC2)N1S(=O)(=O)c1ccc(F)cc1 CHEMBL236185 IC50 10.0 nM
CC[C@@H]1CCC[C@H](C2(OC(=O)N3CCN(CCO)[C@@H](C)C3)CC2)N1S(=O)(=O)c1ccc(Cl)cc1 CHEMBL236182 IC50 10.0 nM
Nc1ccc2nc(-c3ccc(F)cc3)sc2c1 CHEMBL568061 Ki 10.0 nM
CCS(=O)(=O)CC[C@@H]1CCC[C@@]2(S(=O)(=O)c3ccc(Cl)cc3)c3c(F)ccc(F)c3OC[C@@H]12 CHEMBL3659992 IC50 10.0 nM
C[C@@]1(c2nc(NC(=O)c3ncc(Cl)cc3Cl)ccc2F)CO[C@@](C)(C(F)(F)F)C(N)=N1 CHEMBL3670372 IC50 10.0 nM
O=S(=O)(c1ccc(Cl)cc1)[C@@]12CCCC3(COC3)[C@@H]1COc1c(F)ccc(F)c12 CHEMBL3629739 IC50 10.1 nM
O=S(=O)(CC[C@@H]1OCC[C@@]2(S(=O)(=O)c3ccc(Cl)cc3)c3c(F)ccc(F)c3OCC12)c1ccnnc1 CHEMBL3935559 IC50 10.2 nM
Cn1ccc2cc(-c3nc4ccc(F)nc4o3)cnc21 CHEMBL2203385 IC50 10.5 nM
N#CC(C#N)=C/C=C/C=C/c1ccc2ccn(Cc3ccccc3)c2c1 CHEMBL5415091 Ki 10.5 nM
COc1ccc(/C=N/c2nc3ccc(OC)cc3s2)cc1 CHEMBL2296466 Ki 10.82 nM
CN(C)c1ccc(-c2nc3ccc(C#N)cc3s2)cc1 CHEMBL92801 Ki 11.0 nM
CC1=NC2(N=C1N)c1cc(-c3cncc(Cl)c3)ccc1CCC21CC1 CHEMBL3672720 IC50 11.0 nM
CN(C)c1ccc(-c2cn3cc([123I])ccc3n2)cc1 CHEMBL599472 Ki 11.0 nM
N#CC(C#N)=C/C=C/c1cn(Cc2ccccc2)c2ccccc12 CHEMBL5399057 Ki 11.0 nM
CN(C)c1ccc(C#Cc2cnc(OCCOCCOCCF)c(Br)c2)cc1 CHEMBL398059 Ki 11.2 nM
CNc1ccc(-c2nc3cccc(O)c3s2)cc1 CHEMBL486529 Ki 11.2 nM
CNc1ccc(/C=C/c2ccc(OCCOCCOCCF)nc2)cc1 CHEMBL1908919 Ki 11.4 nM
Nc1ccc(-c2cc3cc(O)ccc3o2)cc1 CHEMBL380476 Ki 11.5 nM
CNc1ccc(-c2nc3cc(O)ccc3s2)cc1 CHEMBL503833 Ki 11.5 nM
COc1ccc2oc(-c3ccc(N(C)C)cc3)cc2c1 CHEMBL383116 Ki 12.0 nM
Nc1ccc(/C=C/C=C/C=C/c2ccc(NCCF)cc2)cc1 CHEMBL205332 Ki 12.0 nM
Nc1ccc(C#Cc2ccc(OCCOCCF)cc2)cc1 CHEMBL373663 Ki 12.0 nM
CC[C@@H]1CCC[C@H](C2(OC(=O)N3CCN(CCO)CC3)CC2)N1S(=O)(=O)c1ccc(Cl)cc1 CHEMBL240070 IC50 12.0 nM
CC(C)(CO)N1CCN(C(=O)OC2([C@H]3CCC[C@@H](C4CC4)N3S(=O)(=O)c3ccc(Cl)cc3)CC2)CC1 CHEMBL393941 IC50 12.0 nM
CC[C@@H]1CCC[C@H](C2(OC(=O)N3CCN(CCO)C[C@@H]3C)CC2)N1S(=O)(=O)c1ccc(Cl)cc1 CHEMBL392059 IC50 12.0 nM
Brc1ccc(OCc2ccc(I)cc2)cc1 CHEMBL3314330 Ki 12.0 nM
[C-]#[N+]c1cc(Cl)cc(-c2cc3c(cc2C)C[C@]2(CC[C@@H](OC)CC2)C32N=C(C)C(N)=N2)c1 CHEMBL3937729 IC50 12.0 nM
C[C@]1(c2nc(NC(=O)c3ncc(Cl)cc3Cl)ccc2F)N=C(N)OCC1(F)F CHEMBL2386724 IC50 12.0 nM
CNc1ccc(/C=C/c2ccc(OCCCCCCCCCCCCCCCCCCCCF)cc2)cc1 CHEMBL565658 Ki 12.2 nM
Nc1c2c(nc3ccccc13)CCCC2 CHEMBL95 IC50 12.21 nM
CNc1ccc(C#Cc2cnc(OCCO)c(I)c2)cc1 CHEMBL232113 Ki 12.5 nM
C[C@@]1(c2cc(NC(=O)c3ccc(F)cn3)ccc2F)Cn2c(C#N)cnc2C(N)=N1 CHEMBL5088449 IC50 12.6 nM
N#CC(C#N)=C/C=C/C=C/c1cn(Cc2ccccc2)c2ccccc12 CHEMBL5436166 Ki 12.8 nM
O=S(=O)(CC[C@@H]1OCC[C@@]2(S(=O)(=O)c3ccc(Cl)cc3)c3c(F)ccc(F)c3OCC12)c1cncnc1 CHEMBL3909054 IC50 12.9 nM
CN(C)c1ccc(-c2cn3cc(F)ccc3n2)cc1 CHEMBL241967 Ki 13.0 nM
C[C@]1(c2nc(NC(=O)c3nn(C(F)F)cc3Cl)ccc2F)N=C(N)OCC1(F)F CHEMBL2386726 IC50 13.0 nM
CNc1ccc(C#Cc2cnc(OCCOCCOCCF)c(Br)c2)cc1 CHEMBL231918 Ki 13.1 nM
CN(C)c1ccc(-c2cc(=O)c3cc(I)ccc3o2)cc1 CHEMBL375934 Ki 13.2 nM
CN(C)c1ccc(-c2nnc(-c3cccc(I)c3)o2)cn1 CHEMBL3134121 Ki 13.6 nM
CN(C)c1ccc(-c2cn3cc([125I])ccc3n2)cc1 CHEMBL71696 Ki 13.65 nM
COc1ccc(C#CC(=O)c2ccc(I)cc2)cc1 CHEMBL1643338 Ki 13.7 nM
CN1C(=O)C(=C/C=C/C=C/c2ccc(N(C)C)cc2)C(=O)N(C)C1=O CHEMBL5192359 Ki 13.7 nM
Fc1ccc2nc(-c3ccc4[nH]ccc4c3)oc2n1 CHEMBL2203382 IC50 13.8 nM
CNc1c2ccc(I)cc2nc2ccc(OC)cc12 CHEMBL2326891 Ki 13.8 nM
O=S(=O)(c1ccc(Cl)cc1)[C@@]12CCC[C@]3(CCOC3)[C@@H]1COc1c(F)ccc(F)c12 CHEMBL3629738 IC50 13.9 nM
O=C(OC1([C@H]2CCC[C@@H](CC(F)(F)F)N2S(=O)(=O)c2ccc(Cl)cc2)CC1)N1CCN(CCO)CC1 CHEMBL240071 IC50 14.0 nM
CNc1ccc(-c2nc3ccc(OC)cc3s2)c(F)n1 CHEMBL2048305 IC50 14.0 nM
O=S(=O)(NC[C@@H]1CCC[C@@]2(S(=O)(=O)c3ccc(Cl)cc3)c3c(F)ccc(F)c3OC[C@@H]12)C(F)(F)F CHEMBL1086287 IC50 14.0 nM
C[C@]1(c2nc(NC(=O)c3ccc(C#N)cn3)ccc2F)N=C(N)OCC1(F)F CHEMBL2386719 IC50 14.0 nM
Oc1ccc(/C=C/c2cnc(OCCOCCOCCF)c(Br)c2)cc1 CHEMBL226662 Ki 14.2 nM
CN(CCO)c1ccc2cc(/C=C/C=C/C=C(C#N)C#N)ccc2c1 CHEMBL5199963 Kd 14.5 nM
N#CC(C#N)=C/C=C/c1ccc2c(ccn2Cc2ccccc2)c1 CHEMBL5440504 Ki 14.6 nM
Nc1ccc(/C=C/c2ccc(OCC(CO)CF)cc2)cc1 CHEMBL198597 Ki 15.0 nM
CN(C)c1ccc(/C=C/c2ccc(OCC(CO)C[18F])cc2)cc1 CHEMBL1169460 Ki 15.0 nM
CCC[C@H](C(N)=O)[C@@H](CC(C)C)C(=O)N[C@H]1CCCCN(Cc2cccc(Nc3ccccc3)c2)C1=O CHEMBL205907 IC50 15.0 nM
O=C(O[C@H]1CCC2CCCC1N2S(=O)(=O)c1ccc(Cl)cc1)N1CCC(N2CCCCC2)CC1 CHEMBL236193 IC50 15.0 nM
CC[C@@H]1CCC[C@H](C2(OC(=O)N3CCN(CCCO)CC3)CC2)N1S(=O)(=O)c1ccc(Cl)cc1 CHEMBL236183 IC50 15.0 nM
O=S(=O)(c1ccc(Cl)cc1)[C@@]12CCO[C@@H](CCC(O)CO)[C@@H]1COc1c(F)ccc(F)c12 CHEMBL3659994 IC50 15.0 nM
CN(C)c1ccc(/C=C/C=C2\C(=O)Nc3ncccc32)cc1 CHEMBL3593904 Ki 15.3 nM
OCCOc1ncc(/C=C/c2ccc(O)cc2)cc1I CHEMBL227923 Ki 15.5 nM
CNc1ccc(-c2cnc3cc(OCC[18F])ccc3n2)cc1 CHEMBL2407621 Ki 15.7 nM
CNc1ccc(-c2cnc3cc(OCCF)ccc3n2)cc1 CHEMBL2407615 Ki 15.7 nM
O=C(OC[C@H]1CCC[C@@H](c2ccccc2)N1S(=O)(=O)c1ccc(Cl)cc1)N1CCC(N2CCCCC2)CC1 CHEMBL396543 IC50 16.0 nM
O=C(OC1([C@H]2CCC[C@@H](C3CC3)N2S(=O)(=O)c2ccc(Cl)cc2)CC1)N1CCN(CCCO)CC1 CHEMBL236192 IC50 16.0 nM
CC[C@@H]1CCC[C@H](C2(OC(=O)N3CCC(N4CCCCC4)CC3)CC2)N1S(=O)(=O)c1ccc(F)cc1 CHEMBL236187 IC50 16.0 nM
CC[C@@H](C)Oc1ccc2c(c1)C1(N=C(C)C(N)=N1)[C@]1(CC[C@H](OC)CC1)C2 CHEMBL3672702 IC50 16.0 nM
CC1=NC2(N=C1N)c1cc(-c3cc(Cl)cc(C#N)c3)ccc1CCC21CC1 CHEMBL3672729 IC50 16.0 nM
CCN(CC)c1ccc(/C=C/C2=CC(/C=C/c3ccc(N(CC)CC)nc3)=[O+][B-](F)(F)O2)cn1 CHEMBL5169704 Kd 16.0 nM
COc1ccc(Nc2ccc3c(c2)C(=O)N(C)C3=O)cc1 CHEMBL598082 Ki 16.3 nM
Oc1ccc(C#Cc2ccc(OCCOCCOCCF)cc2)cc1 CHEMBL227751 Ki 16.5 nM
COc1ccc(S(=O)(=O)CC[C@@H]2OCC[C@@]3(S(=O)(=O)c4ccc(Cl)cc4)c4c(F)ccc(F)c4OCC23)cn1 CHEMBL3905561 IC50 16.5 nM
CN(C)c1ccc(C#Cc2cnc(OCCOCCOCCF)c(I)c2)cc1 CHEMBL231915 Ki 16.8 nM
CCC[C@H](C(N)=O)[C@@H](CC(C)C)C(=O)N[C@H]1CCCCN(Cc2cccc(Nc3ccc(F)c(Cl)c3)c2)C1=O CHEMBL208504 IC50 17.0 nM
CCC[C@H](C(N)=O)[C@@H](CC(C)C)C(=O)N[C@H]1CCCCN(Cc2cccc(Nc3cccc(C)c3)c2)C1=O CHEMBL208350 IC50 17.0 nM
O=C(OC1([C@H]2CCC[C@@H](c3cc(F)cc(F)c3)N2S(=O)(=O)c2ccc(Cl)cc2)CC1)N1CC[C@@H](O)C1 CHEMBL240284 IC50 17.0 nM
CC#Cc1cncc(-c2cc3c(cc2C)C[C@]2(CC[C@@H](OC)CC2)C32N=C(C)C(N)=N2)c1 CHEMBL3913223 IC50 17.0 nM
C[C@@]1(c2cccc(NC(=O)c3ccc(Br)cn3)c2)COCC(N)=N1 CHEMBL3653341 IC50 17.0 nM
COc1cnc(C(=O)Nc2ccc(F)c([C@]3(C)CO[C@@](C)(C(F)(F)F)C(N)=N3)c2)c(C)c1 CHEMBL5075177 IC50 17.0 nM
O=C(COC(=O)c1ccc(O)c(O)c1)Nc1c2c(nc3ccccc13)CCCC2 CHEMBL3800453 IC50 17.36 nM
CN(C)c1ccc(OCc2ccc(I)cc2)cc1 CHEMBL3314340 Ki 17.6 nM
N#CC(C#N)=C/C=C/C=C/c1cccc2c1ccn2Cc1ccccc1 CHEMBL5400950 Ki 17.9 nM
COc1cc(/C=c2\sc3nc(-c4ccc(Cl)cc4)cn3c2=O)cc(Br)c1O CHEMBL3286984 IC50 18.0 nM
COc1cc(/C=c2\sc3nc(-c4ccc(Cl)cc4)cn3c2=O)cc(O)c1O CHEMBL3286985 IC50 18.0 nM
Nc1ncccc1S(=O)(=O)CC[C@@H]1OCC[C@@]2(S(=O)(=O)c3ccc(Cl)cc3)c3c(F)ccc(F)c3OCC12 CHEMBL3984227 IC50 18.0 nM
COc1ccc(-c2ccc(-c3ccc([N+](=O)[O-])cc3)s2)cc1 CHEMBL205403 Ki 18.5 nM
CNc1ccc(/C=C/c2ccc(OCCCCCCCCCCCCCCCCCCF)cc2)cc1 CHEMBL585301 Ki 18.5 nM
Clc1ccc(OCc2ccc(I)cc2)cc1 CHEMBL3314329 pKi 18.62 nM
O=c1ccc(S(=O)(=O)CC[C@@H]2OCC[C@@]3(S(=O)(=O)c4ccc(Cl)cc4)c4c(F)ccc(F)c4OCC23)c[nH]1 CHEMBL3971184 IC50 18.7 nM
CNc1ccc(-c2nc3c(O)cccc3s2)cc1 CHEMBL524651 Ki 18.8 nM
[3H]C([3H])([3H])N(c1ccc(-c2nc3ccc(O)cc3s2)cn1)C([3H])([3H])[3H] CHEMBL1744460 IC50 19.0 nM
CNc1ccc(-c2cc3cc(C(N)=O)ccc3o2)c(F)n1 CHEMBL2048309 IC50 19.0 nM
CO[C@H]1CC[C@]2(CCc3ccc(-c4cncc(Cl)c4)cc3C23N=C(C)C(N)=N3)CC1 CHEMBL3672726 IC50 19.0 nM
C[C@]1(c2nc(NC(=O)c3ncc(C#CCO)cc3Cl)ccc2F)N=C(N)OCC1(F)F CHEMBL4113786 IC50 19.0 nM
CN1C(=O)c2ccc(Nc3ccc(O)cc3)cc2C1=O CHEMBL598083 Ki 19.7 nM
COc1cc(/C=C/C(C)=O)cc(I)c1O CHEMBL216553 Ki 19.97 nM
Cc1ccc2nc(-c3ccc(N[11CH3])cc3)sc2c1 CHEMBL5181356 Ki 20.2 nM
CN(C)c1ccc(C#CC(=O)c2ccc(F)cc2)cc1 CHEMBL1643337 Ki 20.4 nM
Oc1ccc(/C=C/c2cnc(OCCOCCOCCF)c(I)c2)cc1 CHEMBL228094 Ki 21.0 nM
Nc1ccc(-c2nc3ccc(-c4nc5ccccc5s4)cc3s2)cc1I CHEMBL242347 Ki 21.0 nM
CN(C)c1ccc(OCc2ccc(OCCF)cc2)cc1 CHEMBL3760007 Ki 21.0 nM
COc1ccc(-c2ccc(-c3ccc(NCCF)cc3)s2)cc1 CHEMBL202938 Ki 21.5 nM
Nc1ccc(C#Cc2ccc(OCCOCCOCCF)cc2)cc1 CHEMBL226610 Ki 21.5 nM
N#CC(C#N)=Cc1ccc2c(ccn2Cc2ccccc2)c1 CHEMBL5438577 Ki 21.5 nM
N#CC(C#N)=Cc1cn(Cc2ccccc2)c2ncccc12 CHEMBL5423638 Ki 21.6 nM
N#CC(C#N)=C/C=C/c1cn(Cc2cccnc2)c2ccccc12 CHEMBL5395343 Ki 21.6 nM
Ic1ccc(COc2ccc(I)cc2)cc1 CHEMBL3314331 pKi 21.88 nM
CNc1ccc(-c2nc3ccc(-c4nc5ccccc5s4)cc3s2)cc1 CHEMBL394523 Ki 22.0 nM
CN(C)c1ccc(/C=C/c2ccc(F)cc2)cc1 CHEMBL81999 Ki 22.0 nM
COc1ccc(/C=C/c2cccc(I)c2)cc1 CHEMBL565281 Ki 22.0 nM
C[C@@]1(c2cc(NC(=O)c3ncc(Cl)cc3Cl)ccc2F)CO[C@@](C)(C(F)(F)F)C(N)=N1 CHEMBL5085959 IC50 22.0 nM
C[C@@]1(c2cc(NC(=O)c3ccc(Br)cn3)ccc2F)CO[C@@](C)(C(F)(F)F)C(N)=N1 CHEMBL3653401 IC50 22.0 nM
Oc1ccc2nc(-c3ccc(F)cc3)sc2c1 CHEMBL490084 Ki 22.5 nM
COc1ccc(CC(=O)OCC(=O)Nc2c3c(nc4ccccc24)CCCC3)cc1OC CHEMBL3797706 IC50 22.54 nM
CNc1ccc(-c2cc(=O)c3cc(I)ccc3o2)cc1 CHEMBL224643 Ki 22.6 nM
CN(C)c1ccc(-c2nc3ccc(-c4nc5ccc(F)cc5s4)cc3s2)cc1 CHEMBL242132 Ki 23.0 nM
CC1=NC2(N=C1N)c1cc(-c3cc(F)cc(C#N)c3)ccc1CCC21CC1 CHEMBL3672718 IC50 23.0 nM
COCCOc1cnc(C(=O)Nc2ccc(F)c([C@]3(C)CO[C@@](C)(C(F)(F)F)C(N)=N3)n2)c(N)n1 CHEMBL5080033 IC50 23.0 nM
CNc1ccc(-c2nc3ccc(F)nc3o2)cc1 CHEMBL2203378 IC50 23.1 nM
O=S(=O)(N1CC[C@]2(CCC[C@@]3(S(=O)(=O)c4ccc(Cl)cc4)c4c(F)ccc(F)c4OC[C@@H]23)C1)C(F)(F)F CHEMBL3629743 IC50 23.3 nM
CNc1ccc(-c2cc3cc(O)ccc3o2)c(F)n1 CHEMBL2048308 IC50 24.0 nM
C[C@@]1(c2nc(NC(=O)c3ncc(OC(F)F)cc3Cl)ccc2F)CO[C@@](C)(C(F)(F)F)C(N)=N1 CHEMBL3670371 IC50 24.0 nM
C[C@@]1(c2cc(NC(=O)c3ncc(C#N)cn3)ccc2F)CO[C@@](C)(C(F)(F)F)C(N)=N1 CHEMBL3653403 IC50 24.0 nM
CN(C)c1ccc(-c2cn3cc(Cl)ccc3n2)cc1 CHEMBL394553 Ki 24.2 nM
COc1cc(/C=C/c2ccc(O)cc2)ccc1/C=C/c1ccc(O)cc1 CHEMBL2181036 Ki 24.2 nM
COc1ccc(OCc2ccc(I)cc2)cc1 CHEMBL3314322 Ki 24.3 nM
CN1c2ccccc2Sc2cc(/C=C3/SC(=S)N(CC(=O)OCC4COC(C)(C)O4)C3=O)ccc21 CHEMBL4475538 Kd 24.5 nM
N#CC(C#N)=C/C=C/c1ccc2ccn(Cc3ccccc3)c2c1 CHEMBL5405459 Ki 24.5 nM
CN(C)c1ccc(-c2nnc(-c3ccc(I)cc3)o2)cn1 CHEMBL3134120 Ki 24.8 nM
COc1cc(/C=C/C(O)=C/C(C)=O)cc(I)c1O CHEMBL217923 Ki 24.9 nM
COc1ccc2nc(-c3ccc4nc(-c5ccc(N)cc5)sc4c3)sc2c1 CHEMBL398155 Ki 25.0 nM
Nc1ccc(-c2nc3ccc(-c4nc5ccccc5s4)cc3s2)cc1 CHEMBL243630 Ki 25.0 nM
CC[C@@H]1CCC[C@H](C2(OC(=O)N3CC4CCC(C3)N4CCO)CC2)N1S(=O)(=O)c1ccc(F)cc1 CHEMBL236186 IC50 25.0 nM
O=C(C[C@@H]1CC[C@@]2(S(=O)(=O)c3ccc(C(F)(F)F)cc3)c3c(F)ccc(F)c3OC[C@H]2C1)NCC(F)(F)F CHEMBL3659995 IC50 25.0 nM
CN(C)c1ccc(/C=C2\COc3ccc(Br)cc3C2=O)cc1Br CHEMBL3126518 Ki 25.54 nM
Fc1ccc2nc(-c3cnc4[nH]ccc4c3)oc2n1 CHEMBL2203384 IC50 25.7 nM
CN(C)c1ccc(COc2ccc(OCCF)cc2)cc1 CHEMBL3758709 Ki 25.7 nM
C[C@@]1(c2nc(NC(=O)c3ncc(C(F)(F)F)nc3N)ccc2F)CO[C@@](C)(C(F)(F)F)C(N)=N1 CHEMBL3670385 IC50 26.0 nM
Nc1ccc(-c2nc3ccc(F)cc3s2)cc1 CHEMBL284575 Ki 26.2 nM
N#CC(C#N)=C/C=C/C=C/c1cn(Cc2ccccc2)c2ncccc12 CHEMBL5420492 Ki 26.3 nM
O=S(=O)(c1ccc(Cl)cc1)[C@@]12CCCC3(CCSCC3)[C@@H]1COc1c(F)ccc(F)c12 CHEMBL3629742 IC50 26.4 nM
CN(C)c1ccc(/C=C/C=C/C=C(C#N)C#N)cc1 CHEMBL5174620 Kd 26.9 nM
CNc1ccc(-c2nc3ccc(-c4nc5ccc(F)cc5s4)cc3s2)cc1 CHEMBL396212 Ki 27.0 nM
O=C(OC1([C@H]2CCC[C@@H](C3CC3)N2S(=O)(=O)c2ccc(Cl)cc2)CC1)N1CCN(CCO)CC1 CHEMBL240069 IC50 27.0 nM
CC[C@@H]1CCC[C@H](C2(OC(=O)N3CC4CCC(C3)N4CCO)CC2)N1S(=O)(=O)c1ccc(F)c(F)c1 CHEMBL236189 IC50 27.0 nM
O=S(=O)(N[C@@H]1CC[C@@]2(S(=O)(=O)c3ccc(Cl)cc3)c3c(F)ccc(F)c3OC[C@H]2C1)C(F)(F)F CHEMBL1090209 IC50 27.0 nM
C[C@]1(c2nc(NC(=O)c3ncc(C(F)(F)F)cc3Cl)ccc2F)N=C(N)OCC1(F)F CHEMBL2386723 IC50 27.0 nM
CC1=CC(C)=[N+]2C1=C(CCCN1CCNc3ccccc31)c1c(C)cc(/C=C/c3ccc(N(C)C)s3)n1[B-]2(F)F CHEMBL5180854 Kd 27.0 nM
CN(C)c1ccc(/C=C/C=C2\C(=O)Nc3ccccc32)cc1 CHEMBL3593903 Ki 27.6 nM
CCCC1(O)CCN(C(=O)OC2([C@H]3CCC[C@@H](CC)N3S(=O)(=O)c3ccc(Cl)cc3)CC2)C1 CHEMBL238271 IC50 28.0 nM
CN(CCF)c1ccc(-c2cc3ccccc3[nH]2)cc1 CHEMBL2397721 Ki 28.4 nM
COc1ccc2nc3cc(I)ccc3c(OC)c2c1 CHEMBL2326889 Ki 28.9 nM
CCC[C@H](C(N)=O)[C@@H](CC(C)C)C(=O)N[C@H]1CCCCN(Cc2cccc(Nc3ccccc3Cl)c2)C1=O CHEMBL382880 IC50 29.0 nM
COc1ccc(-c2cc(=O)c3cc(I)ccc3o2)cc1 CHEMBL224064 Ki 29.0 nM
CC[C@@H]1CCC[C@H](C2(OC(=O)N3CCC(N4CCCCC4)CC3)CC2)N1S(=O)(=O)c1cc(F)cc(F)c1 CHEMBL429448 IC50 29.0 nM
O=S(=O)(N[C@@H]1CC[C@@]2(S(=O)(=O)c3ccc(Cl)cc3)c3c(F)ccc(F)c3OC[C@@]2(O)C1)C1CC1 CHEMBL1778349 IC50 29.0 nM
CCC[C@H](C(N)=O)[C@@H](CC(C)C)C(=O)N[C@H]1CCCCN(Cc2cccc(Nc3ccc(C(F)(F)F)cc3)c2)C1=O CHEMBL424684 IC50 30.0 nM
CNc1ncc(-c2cc3cc(O)ccc3o2)cc1F CHEMBL2048310 IC50 30.0 nM
C[C@]1(c2nc(NC(=O)c3ncc(OCF)nc3N)ccc2F)N=C(N)OCC1(F)F CHEMBL4110172 IC50 30.0 nM
C[C@@]1(c2nc(NC(=O)c3ncc(C(F)(F)F)cc3N)ccc2F)CO[C@@](C)(C(F)(F)F)C(N)=N1 CHEMBL5070669 IC50 30.0 nM
Cn1ncc2cc(-c3nc4ccc(F)nc4o3)cnc21 CHEMBL2203387 IC50 30.2 nM
COc1cc(C(=O)OCC(=O)Nc2c3c(nc4ccccc24)CCCC3)cc(OC)c1OC CHEMBL3797363 IC50 30.74 nM
CN(CCF)c1ccc(-c2cn3cc(I)ccc3n2)cc1 CHEMBL70894 Ki 31.0 nM
CN(C)c1ccc(/C=C2\Nc3ccc(I)cc3C2=O)cc1 CHEMBL2069433 Ki 31.0 nM
COc1cc(-c2cn([C@H]3CCc4c(F)cccc4N(CC(F)(F)F)C3=O)nn2)ccc1-n1cnc(C)c1 CHEMBL3609749 IC50 31.0 nM
CNc1ccc(-c2ccc(-c3ccc(O)cc3)s2)cc1 CHEMBL205512 Ki 31.2 nM
CN(CCCF)c1ccc(-c2cc3ccccc3[nH]2)cc1 CHEMBL2397722 Ki 31.5 nM
Oc1ccc(/C=C/c2cccc(I)c2)cc1 CHEMBL567614 Ki 32.0 nM
COc1ccc2oc(-c3ccc(C(N)=O)nc3F)cc2c1 CHEMBL2048311 IC50 32.0 nM
CNc1ccc(-c2cc3cc(C(N)=O)ccc3o2)nc1F CHEMBL2048314 IC50 32.0 nM
COc1cc(/C=c2\sc3nc(-c4ccc(Cl)cc4)cn3c2=O)cc(Cl)c1O CHEMBL3286983 IC50 32.0 nM
COc1cc(/C=c2\sc3nc(-c4ccncc4C)cn3c2=O)cc(OC)c1O CHEMBL3286987 IC50 32.0 nM
C[C@@]1(c2cccc(NC(=O)c3ccc(Br)cn3)c2)CO[C@@](C)(C(F)(F)F)C(N)=N1 CHEMBL3653399 IC50 32.0 nM
CNc1ccc(/C=C/c2ccc(OCC(CO)CO)cc2)cc1 CHEMBL196941 Ki 32.5 nM
COc1ccc(-c2nc3ccc(F)nc3o2)cc1 CHEMBL2203288 IC50 32.5 nM
COc1ccc2cc(-c3ccc(C(N)=O)cn3)oc2c1 CHEMBL1084946 IC50 33.0 nM
Oc1ccc2nc(-c3ccc(NCCF)nc3)sc2c1 CHEMBL2048302 IC50 33.0 nM
Nc1ccc(-c2nc3ccc(-c4nc5ccc(Cl)cc5s4)cc3s2)cc1 CHEMBL243838 Ki 34.0 nM
COc1ccc2nc(/N=C/c3ccc(O)cc3)sc2c1 CHEMBL2296463 Ki 34.72 nM
CN1c2ccccc2Sc2cc(/C=C3/SC(=S)N(CC(=O)OCC(O)CO)C3=O)ccc21 CHEMBL4453231 Kd 34.9 nM
CNc1ccc2nc(-c3ccc(C(N)=O)nc3)sc2c1 CHEMBL1077208 IC50 35.0 nM
COc1ccc2nc(-c3ccc(NCCF)nc3)oc2c1 CHEMBL2048300 IC50 35.0 nM
CNc1ccc(-c2cc3cc(O)ccc3o2)nc1F CHEMBL2048313 IC50 35.0 nM
COc1nc(C2=NOC[C@H](c3cc4ccccc4o3)N2)ccc1-n1cnc(C)c1 CHEMBL4101809 EC50 35.0 nM
Fc1ccc2nc(-c3ccc4ncsc4c3)oc2n1 CHEMBL2203388 IC50 35.8 nM
Nc1ccc(-c2nc3ccc(-c4nc5ccc(F)cc5s4)cc3s2)cc1 CHEMBL241917 Ki 36.0 nM
O=C1Nc2ccccc2/C1=C/C=C/c1ccc([N+](=O)[O-])cc1 CHEMBL3593922 Ki 36.2 nM
Nc1ccc(-c2nc3ccccc3s2)cc1 CHEMBL93118 Ki 37.0 nM
CN(C)c1ccc(/C=C/C=C2\C(=O)Nc3ccc(O)cc32)cc1 CHEMBL3593905 Ki 37.1 nM
COc1cc(C(=O)OCC(=O)Nc2c3c(nc4ccccc24)CCCC3)ccc1O CHEMBL3797381 IC50 37.36 nM
CN(C)c1ccc(/C=C/c2ccc(OCC(CO)CO)cc2)cc1 CHEMBL196407 Ki 38.0 nM
COc1ccc2nc(-c3ccc(N(C)C)cc3)cn2c1 CHEMBL243492 Ki 38.5 nM
CN(C)c1ccc(/C=C/C2=CC(/C=C/c3ccc(N(C)C)cc3)=[O+][B-](F)(F)O2)cc1 CHEMBL5183943 Kd 38.69 nM
O=C(COC(=O)Cc1c[nH]c2ccccc12)Nc1c2c(nc3ccccc13)CCCC2 CHEMBL3799641 IC50 38.96 nM
COc1cc(/C=C2\COc3ccc(Br)cc3C2=O)cc(OC)c1 CHEMBL3126522 Ki 39.19 nM
COc1c2ccc(I)cc2nc2ccc(N(C)C)cc12 CHEMBL2326888 Ki 39.2 nM
Oc1ccc(/C=C/c2ccc(/C=C/c3ccc(O)cc3)c(OCC(F)(F)F)c2)cc1 CHEMBL3233658 Ki 39.3 nM
CN(C)c1ccc(/C=C2\C(=O)Nc3ncccc32)cc1 CHEMBL3593893 Ki 40.0 nM
N#CC(C#N)=C/C=C/C=C/c1cccc2ccn(Cc3ccccc3)c12 CHEMBL5435422 Ki 40.9 nM
CN(CCCF)c1ccc(-c2cn3cc(I)ccc3n2)cc1 CHEMBL69671 Ki 41.0 nM
CN(C)c1ncc(-c2nc3ccc(O)cc3s2)cn1 CHEMBL1088617 IC50 41.0 nM
CN(C)c1ccc(-c2nc3ccc(F)nc3o2)cn1 CHEMBL2203381 IC50 41.8 nM
N#CC(C#N)=Cc1c[nH]c2ccccc12 CHEMBL303903 Ki 42.2 nM
N#CC(C#N)=Cc1cn(Cc2cccnc2)c2ccccc12 CHEMBL5414142 Ki 43.5 nM
CNc1ccc(-c2nc3ccc(O)cc3s2)nc1F CHEMBL2048304 IC50 44.0 nM
NC(=O)c1ccc(-c2cc3cc(O)ccc3o2)c(F)n1 CHEMBL2048312 IC50 44.0 nM
CNc1ccc(-c2cc3ccc(O)cc3o2)cn1 CHEMBL1084943 IC50 45.0 nM
C[C@]1(c2nc(NC(=O)c3ncc(Cl)cc3N)ccc2F)N=C(N)OCC1(F)F CHEMBL4115329 IC50 45.0 nM
O=C(COC(=O)Cc1ccc(O)cc1)Nc1c2c(nc3ccccc13)CCCC2 CHEMBL3798857 IC50 45.29 nM
Fc1ccc2nc(-c3ccc4cc[nH]c4c3)oc2n1 CHEMBL2203389 IC50 45.3 nM
CCN(CC)c1ccc(/C=C/C2=CC(/C=C/c3ccc(N(C)C)cc3)=[O+][B-](F)(F)O2)cn1 CHEMBL5183307 Kd 45.8 nM
COc1cc(/C=C/C(=O)OCC(=O)Nc2c3c(nc4ccccc24)CCCC3)cc(OC)c1OC CHEMBL3799950 IC50 45.88 nM
CN(C)c1ccc(/C=C/C=C2\C(=O)N(c3ccncc3)c3ccccc32)cc1 CHEMBL3593912 Ki 45.9 nM
Nc1ccc(-c2nc3ccc(O)cc3s2)cc1 CHEMBL93884 Ki 46.0 nM
O=C(OC1([C@H]2CCC[C@@H](C3CC3)N2S(=O)(=O)c2ccc(Cl)cc2)CC1)N1CC[C@@H](O)C1 CHEMBL398395 IC50 46.0 nM
COc1ccc(/C=C/C(=O)OCC(=O)Nc2c3c(nc4ccccc24)CCCC3)cc1O CHEMBL3798813 IC50 46.12 nM
CCOC(=O)CN(CC(=O)OCC)C(=O)CN1C(=O)/C(=C\c2ccc3c(c2)Sc2ccccc2N3C)SC1=S CHEMBL4570231 Kd 46.3 nM
CCC[C@@H]1CCC[C@H](C2(OC(=O)N3CC[C@@H](O)C3)CC2)N1S(=O)(=O)c1ccc(Cl)cc1 CHEMBL240285 IC50 47.0 nM
CN1CCc2cc(-c3nc4ccc(F)nc4o3)cnc21 CHEMBL2203386 IC50 47.0 nM
CNc1ccc(OCc2ccc(I)cc2)cc1 CHEMBL3314337 pKi 47.86 nM
CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)C[C@@H](Cc1ccccc1)C(N)=O CHEMBL5283881 IC50 48.0 nM
CN(C)c1ccc2nc(/C=C/C=C/C=C(C#N)C#N)sc2c1 CHEMBL5283353 Kd 48.0 nM
CN(C)c1ccc(-c2cn3cc(CCCF)ccc3n2)cc1 CHEMBL382407 Ki 48.3 nM
CCN(CC)CCCC(C)Nc1c2ccc([125I])cc2nc2ccc(OC)cc12 CHEMBL2326894 Kd 48.4 nM
Cn1ncc2cc(-c3nc4ccc(F)nc4o3)ccc21 CHEMBL2203390 IC50 48.7 nM
COc1ccc(COc2ccc(I)cc2)cc1 CHEMBL3314342 pKi 48.98 nM
COCC[C@]1(c2nc(NC(=O)c3ncc(C#N)cc3C)ccc2F)N=C(N)OCC1(F)F CHEMBL2386722 IC50 49.0 nM
COc1ccc(/C=C/C(=O)OCC(=O)Nc2c3c(nc4ccccc24)CCCC3)cc1OC CHEMBL3800317 IC50 49.14 nM
N#CC(C#N)=Cc1cccc2ccn(Cc3ccccc3)c12 CHEMBL5402942 Ki 49.4 nM
Nc1ccc(/C=C/C=C2\C(=O)Nc3ccccc32)cc1 CHEMBL3593918 Ki 50.8 nM
O=C(COC(=O)/C=C/c1ccc(Cl)cc1)Nc1c2c(nc3ccccc13)CCCC2 CHEMBL3799175 IC50 51.77 nM
COc1ccc(CC(=O)OCC(=O)Nc2c3c(nc4ccccc24)CCCC3)c(OC)c1OC CHEMBL3799558 IC50 51.81 nM
N#CC(C#N)=Cc1cccc2c1ccn2Cc1ccccc1 CHEMBL5396662 Ki 52.0 nM
Cc1c(/C=C/C2=CC(/C=C/c3cnn(-c4ccccc4)c3C)=[O+][B-](F)(F)O2)cnn1-c1ccccc1 CHEMBL5207355 Kd 52.4 nM
CCC[C@H](C(N)=O)[C@@H](CC(C)C)C(=O)N[C@H]1CCCCN(Cc2cccc(Nc3cccc(OC)c3)c2)C1=O CHEMBL410532 IC50 54.0 nM
O=S(=O)(NC[C@@H]1CCC[C@@]2(S(=O)(=O)c3ccc(C(F)(F)F)cc3)c3c(F)ccc(F)c3OC[C@@H]12)C(F)(F)F CHEMBL1085076 IC50 54.0 nM
COc1ccc(/C=C2\COc3ccc(Br)cc3C2=O)cc1OC CHEMBL3126519 Ki 54.22 nM
COc1cc(/C=C/C(C)=O)ccc1O CHEMBL106509 Ki 54.24 nM
Cc1cc(/C=C/c2ccc(N(C)C)s2)n2c1C=C1C=CC=[N+]1[B-]2(F)F CHEMBL5197690 Kd 55.0 nM
COc1cc(OC)cc(C(=O)OCC(=O)Nc2c3c(nc4ccccc24)CCCC3)c1 CHEMBL3798989 IC50 55.86 nM
CC[C@@H]1CCC[C@H](C2(OC(=O)N3CC[C@@H](O)C3)CC2)N1S(=O)(=O)c1ccc(Cl)cc1 CHEMBL240286 IC50 56.0 nM
CN(C)c1ccc(/C=C/C=C2\C(=O)N(C)c3ccccc32)cc1 CHEMBL3593908 Ki 56.0 nM
Oc1ccc(/C=C/c2ccc(/C=C/c3ccc(O)cc3)c(OCCCC(F)(F)F)c2)cc1 CHEMBL3233659 Ki 56.4 nM
CC(C)(CO)N1CCN(C(=O)O[C@H]2CCC3CCCC2N3S(=O)(=O)c2ccc(Cl)cc2)CC1 CHEMBL429449 IC50 57.0 nM
C[C@]1(c2nc(NC(=O)c3ncc(OCF)cc3Cl)ccc2F)N=C(N)OCC1(F)F CHEMBL4111699 IC50 57.0 nM
O=S1(=O)CCC2(CCC[C@@]3(S(=O)(=O)c4ccc(Cl)cc4)c4c(F)ccc(F)c4OC[C@@H]23)CC1 CHEMBL3629741 IC50 57.7 nM
[3H]N(c1ccc(-c2nc3ccc(O)cc3s2)cn1)C([3H])([3H])[3H] CHEMBL1788121 IC50 58.0 nM
[3H]N(c1ccc(-c2nc3ccc(OC)cc3s2)cn1)C([3H])([3H])[3H] CHEMBL1744459 IC50 58.0 nM
CC(F)(F)c1cnc(C(=O)Nc2ccc(F)c([C@@]3(C)N=C(N)OCC3(F)F)n2)c(Cl)c1 CHEMBL4111183 IC50 58.0 nM
CN(C)c1ccc(/C=C/c2ccc(OCC3COC(C)(C)OC3)cc2)cc1 CHEMBL371066 Ki 59.0 nM
O=C(OCCCC1CCc2ccccc2N1S(=O)(=O)c1ccc(Cl)cc1)N1CCC(N2CCCCC2)CC1 CHEMBL231248 IC50 60.0 nM
COc1ccc2cc(-c3ccc(C(N)=O)nc3)oc2c1 CHEMBL1084945 IC50 60.0 nM
O=C1Nc2ccccc2/C1=C\C=C\c1ccc([N+](=O)[O-])cc1 CHEMBL3593923 Ki 60.0 nM
C[C@]1(c2nc(NC(=O)c3ncc(C(F)F)nc3N)ccc2F)N=C(N)OCC1(F)F CHEMBL4112705 IC50 60.0 nM
C[C@]1(c2nc(NC(=O)c3ncc(C#CCO)cc3N)ccc2F)N=C(N)OCC1(F)F CHEMBL4107314 IC50 62.0 nM
CNc1ccc(/C=C/c2ccc(OCCCCCCCCCCCCCCCCCCCCCCCCF)cc2)cc1 CHEMBL570608 Ki 63.0 nM
Nc1ccc(/C=C2\COc3ccc(Br)cc3C2=O)cc1 CHEMBL3126516 Ki 63.57 nM
N#Cc1ccc2nc(-c3ccc(N)cc3)sc2c1 CHEMBL93270 Ki 64.0 nM
Cc1ccc2nc(-c3ccc(N(C)C)cc3)sc2c1 CHEMBL329640 Ki 64.0 nM
COc1ccc(C(=O)OCC(=O)Nc2c3c(nc4ccccc24)CCCC3)c(OC)c1OC CHEMBL3799703 IC50 65.5 nM
CNc1ccc(-c2cc3ccc(OC)cc3o2)cn1 CHEMBL1084944 IC50 66.0 nM
Oc1ccc2nc(-c3ccc(NCCCF)nc3)sc2c1 CHEMBL2048303 IC50 66.0 nM
C[C@]1(c2nc(NC(=O)c3ncc(C(F)F)cc3N)ccc2F)N=C(N)OCC1(F)F CHEMBL4112589 IC50 66.0 nM
CC1(C)OCC2(CCC[C@@]3(S(=O)(=O)c4ccc(Cl)cc4)c4c(F)ccc(F)c4OC[C@@H]23)CO1 CHEMBL3629737 IC50 66.6 nM
Nc1ccc(C#Cc2ccc(OCCOCCOCCO)cc2)cc1 CHEMBL227752 Ki 67.58 nM
CCO[C@@H]([C@H]1C[C@@H](C)[C@H]2[C@H](O1)[C@H](O)[C@@]1(C)[C@@H]3CC[C@H]4C(C)(C)[C@@H](O[C@H]5CN(C6CN(CCOC)C6)CCO5)CC[C@@]45C[C@@]35CC[C@]21C)C(C)(C)O CHEMBL3403819 IC50 68.0 nM
COc1ccc2cc(/C=C/c3ccc(N(C)C)cc3)oc2c1 CHEMBL524141 IC50 70.0 nM
COCCc1cnc(C(=O)Nc2ccc(F)c([C@@]3(C)N=C(N)OCC3(F)F)n2)c(N)n1 CHEMBL4110497 IC50 70.0 nM
CC(C)CC(C(=O)O)c1cc(Cl)c(OCC2CC2)c(-c2ccc(C(F)(F)F)cc2)c1 CHEMBL2151085 EC50 70.0 nM
O=C(O)[C@H](CC1CCC1)c1cc(Cl)c(OCC(F)(F)F)c(-c2ccc(C(F)(F)F)cc2)c1 CHEMBL3609747 EC50 70.0 nM
CNc1ccc(/C=C/c2ccc(OCCOCCOCCOCCNC(=O)CN(CC(=O)NCCOCCOCCOCCOc3ccc(/C=C/c4ccc(NC)cc4)cn3)C(=O)COCCOCCOCCF)nc2)cc1 CHEMBL2042246 Ki 71.2 nM
COc1ccc(CC(=O)OCC(=O)Nc2c3c(nc4ccccc24)CCCC3)cc1 CHEMBL3797646 IC50 71.28 nM
N#CC(C#N)=C/C=C/c1cccc2c1ccn2Cc1ccccc1 CHEMBL5401214 Ki 71.3 nM
O=c1cc(-c2ccc(O)cc2)oc2ccc(I)cc12 CHEMBL388844 Ki 72.5 nM
O=C(OCC1CCc2ccccc2N1S(=O)(=O)c1ccc(Cl)cc1)N1CCC(N2CCCCC2)CC1 CHEMBL231250 IC50 73.0 nM
N#CC(C#N)=Cc1cn(Cc2ccc(I)cc2)c2ccccc12 CHEMBL5431199 Ki 73.0 nM
COc1cccc(/C=C2\COc3ccc(Br)cc3C2=O)c1 CHEMBL3126520 Ki 73.46 nM
COc1ccc(CN2C(=O)/C(=C\C=C\c3ccc([N+](=O)[O-])cc3)c3ccccc32)cc1OC CHEMBL3593930 Ki 73.6 nM
CCC[C@H](C(N)=O)[C@@H](CC(C)C)C(=O)N[C@H]1CCCCN(Cc2cccc(NN3CCCCC3)c2)C1=O CHEMBL208230 IC50 74.0 nM
CNc1ccc(-c2nc3cc(O)ccc3s2)cn1 CHEMBL1082546 IC50 74.0 nM
[3H]C([3H])([3H])N(c1ncc(-c2nc3ccc(O)cc3o2)cn1)C([3H])([3H])[3H] CHEMBL1744464 IC50 75.0 nM
Nc1ccc(C#Cc2ccc(N)cc2)cc1 CHEMBL227625 Ki 76.0 nM
CN1c2ccccc2Sc2cc(/C=C3/SC(=S)N(CC(=O)N(CC(=O)O)CC(=O)O)C3=O)ccc21 CHEMBL4524664 Kd 76.5 nM
O=C(COC(=O)Cc1ccc(Cl)cc1)Nc1c2c(nc3ccccc13)CCCC2 CHEMBL3797623 IC50 77.45 nM
CO[C@H]1CC[C@@]2(CCc3ccc(Br)cc3C23N=C(C)C(N)=N3)CC1 CHEMBL3672721 IC50 78.0 nM
CC1=CC(C)=[N+]2C1=C(CCCO)c1c(C)cc(/C=C/c3cnc(N(C)C)s3)n1[B-]2(F)F CHEMBL5438212 Kd 78.08 nM
C[P@]1(=O)OC[C@]2(CCC[C@@]3(S(=O)(=O)c4ccc(C(F)(F)F)cc4)c4c(F)ccc(F)c4OC[C@@H]23)CO1 CHEMBL3942223 IC50 79.0 nM
Ic1ccc(COc2ccccc2)cc1 CHEMBL3314332 Ki 79.4 nM
CN(CCCF)c1ccc(-c2cc3ccccc3n2C)cc1 CHEMBL2397724 Ki 79.7 nM
CN(C)c1ccc(/C=C/c2ccc(OCC(CO)Cc3ccc(Br)cc3)cc2)cc1 CHEMBL196387 Ki 80.0 nM
CNc1ccc(-c2cn3cc(SC)ccc3n2)cc1 CHEMBL252765 Ki 80.0 nM
CNc1ccc(/C=C/c2cc3cc(OC)ccc3o2)cc1 CHEMBL523824 IC50 80.0 nM
Nc1nc(NCc2ccc(Br)cc2)c2ccccc2n1 CHEMBL3814631 IC50 80.0 nM
COc1cc(C#N)cc(-c2ccc3c(c2)C2(N=C(C)C(N)=N2)[C@]2(CC3)CC[C@H](OC)CC2)c1 CHEMBL3672724 IC50 80.0 nM
CC[C@@H]1CCC[C@H](C2(OC(=O)N3CCN(C(C)(C)CO)CC3)CC2)N1S(=O)(=O)c1cc(F)cc(F)c1 CHEMBL236191 IC50 81.0 nM
COc1ccc2nc(-c3ccc(N(C)C)nc3)sc2c1 CHEMBL1082545 IC50 81.0 nM
CC#Cc1cncc(-c2ccc3c(c2)C2(N=C(C)C(N)=N2)[C@]2(CC3)CC[C@H](OC)CC2)c1 CHEMBL3672727 IC50 81.0 nM
COCC#Cc1cnc(C(=O)Nc2ccc(F)c([C@@]3(C)N=C(N)OCC3(F)F)n2)c(Cl)c1 CHEMBL4107875 IC50 81.0 nM
COc1cnc(C(=O)Nc2ccc(F)c([C@@]3(C)N=C(N)OCC3(F)F)n2)c(C)c1 CHEMBL4111654 IC50 82.0 nM
COc1ccc2nc3cc(I)ccc3c(N)c2c1 CHEMBL2326890 Ki 83.5 nM
CCOC(=O)N1C(=O)/C(=C\C=C\c2ccc(N(C)C)cc2)c2ccccc21 CHEMBL3593913 Ki 84.0 nM
Oc1ccc(/C=C/c2ccc(/C=C/c3ccc(O)cc3)c(OC(C(F)(F)F)(C(F)(F)F)C(F)(F)F)c2)cc1 CHEMBL3233660 Ki 84.48 nM
CNc1ccc(-c2nc3ccc(C(N)=O)cc3s2)cn1 CHEMBL1087548 IC50 85.0 nM
[3H]C([3H])([3H])N(c1ccc(-c2nc3ccc(O)cc3o2)cn1)C([3H])([3H])[3H] CHEMBL1744463 IC50 85.0 nM
CN(C)c1ccc(/C=C/C=C2\C(=O)N(Cc3ccccc3)c3ncccc32)cc1 CHEMBL3593914 Ki 85.1 nM
O=C(NCCCn1ccnc1)OCCCC1CCc2ccccc2N1S(=O)(=O)c1ccc(Cl)cc1 CHEMBL231544 IC50 86.0 nM
CCO[C@@H]([C@H]1C[C@@H](C)[C@H]2[C@H](O1)[C@H](O)[C@@]1(C)[C@@H]3CC[C@H]4C(C)(C)[C@@H](O[C@H]5CN(CC6CN(CCOC)C6)CCO5)CC[C@@]45C[C@@]35CC[C@]21C)C(C)(C)O CHEMBL3403825 IC50 86.0 nM
CCO[C@@H]([C@H]1C[C@@H](C)[C@H]2[C@H](O1)[C@H](O)[C@@]1(C)[C@@H]3CC[C@H]4C(C)(C)[C@@H](O[C@H]5CN(CC6CN(CC(C)(C)O)C6)CCO5)CC[C@@]45C[C@@]35CC[C@]21C)C(C)(C)O CHEMBL3403826 IC50 86.0 nM
CN(C)c1ccc(/C=C2\C(=O)N(c3ccncc3)c3ccccc32)cc1 CHEMBL3593897 Ki 87.1 nM
CN(C)c1ccc(-c2cn3cc(SCCO)ccc3n2)cc1 CHEMBL244995 Ki 88.0 nM
CN(C)c1ccc(-c2cn3cc(Cl)ncc3n2)cc1 CHEMBL244747 Ki 88.0 nM
C[C@]1(c2nc(NC(=O)c3ncc(F)cc3N)ccc2F)N=C(N)OCC1(F)F CHEMBL4109969 IC50 88.0 nM
C[C@]1(c2nc(NC(=O)c3ncccc3Cl)ccc2F)N=C(N)OCC1(F)F CHEMBL4106556 IC50 88.0 nM
CCO[C@@H]([C@H]1C[C@@H](C)[C@H]2[C@H](O1)[C@H](O)[C@@]1(C)[C@@H]3CC[C@H]4C(C)(C)[C@@H](O[C@H]5CNCCO5)CC[C@@]45C[C@@]35CC[C@]21C)C(C)(C)O CHEMBL2207069 IC50 91.0 nM
CN(C)c1ccc(/C=C2\C(=O)Nc3ccccc32)cc1 CHEMBL328710 Ki 91.6 nM
CO[C@H]1CC[C@@]2(CCc3ccc(-c4cc(Cl)cc(C#N)c4)cc3C23N=C(C)C(N)=N3)CC1 CHEMBL3672731 IC50 92.0 nM
CN(C)c1ccc(/C=C/C=C2\C(=O)N(Cc3ccc([N+](=O)[O-])cc3)c3ccccc32)cc1 CHEMBL3593911 Ki 92.4 nM
COc1cc(/C=c2\sc3nc(-c4ccncc4)cn3c2=O)cc(OC)c1O CHEMBL3286981 IC50 93.0 nM
CN(C)c1ccc(/C=C2\C(=O)Nc3ccc(O)cc32)cc1 CHEMBL3593894 Ki 94.8 nM
Nc1ccc(/C=C/c2ccc(O)cc2)cc1 CHEMBL194754 Ki 95.0 nM
CC1=N[C@@]2(N=C1N)c1cc(Br)ccc1C[C@]21CC[C@@H](O)CC1 CHEMBL3672688 IC50 96.0 nM
CNc1ncc(-c2nc3ccc(O)cc3s2)cc1F CHEMBL2048307 IC50 98.0 nM
Cc1cc(C#N)cnc1C(=O)Nc1cc([C@]2(C)CO[C@@](C)(C(F)(F)F)C(N)=N2)c(F)cn1 CHEMBL3261068 IC50 98.0 nM
CN(C)c1ccc(/C=C/C=C2\C(=O)N(Cc3ccc(N)cc3)c3ccccc32)cc1 CHEMBL3593916 Ki 98.9 nM