C[C@]12CCC(=O)C[C@@H]1CC[C@@H]1[C@@H]2CC[C@]2(C)[C@@H](O)CC[C@@H]12 CHEMBL27769 IC50 0.0 nM
C[C@]1(O)CCC2C3CCC4=CC(=O)CC[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]21C CHEMBL302870 IC50 0.0 nM
CCCCC[C@H]1C[C@@]2(C)C(CC[C@@H]2O)C2CCC3=CC(=O)CCC3=C21 CHEMBL184313 IC50 0.009 nM
Cc1cc(N2C(=O)[C@@H]3C4C=CC(CC4)[C@@H]3C2=O)ccc1Br CHEMBL180681 Ki 0.01 nM
C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3C=C[C@@]21C CHEMBL166444 EC50 0.013 nM
N#Cc1ccc(-c2ccccc2O)cc1C(F)(F)F CHEMBL391548 IC50 0.02 nM
Cc1c(C(O)(C2CC2)C(F)(F)F)ccc(C#N)c1C(F)(F)F CHEMBL3818706 pEC50 0.03162 nM
C[C@](O)(COc1ccc(C#N)cc1F)C(=O)N1CCc2c(C#N)cccc21 CHEMBL3238292 EC50 0.039 nM
Cc1c(N[C@@H]2CCC[C@]2(C)O)ccc(C#N)c1Cl CHEMBL3765171 EC50 0.0398 nM
C[C@](O)(COc1ccc(C#N)cc1Br)C(=O)N1CCc2c(C#N)cccc21 CHEMBL3238291 EC50 0.06 nM
C[C@](O)(COc1ccc(F)cc1C#N)C(=O)N1CCc2c(C#N)cccc21 CHEMBL3238288 EC50 0.074 nM
CN1C(=S)N(c2ccc(C#N)c(C(F)(F)F)c2)C(=O)C1(C)C CHEMBL1099140 EC5 0.08 nM
Cc1c(N[C@@H](c2nnc(-c3ccc(C#N)cc3)o2)[C@H](C)O)ccc(C#N)c1Cl CHEMBL1672635 EC50 0.1 nM
COc1ccc2c(c1)c(CC(=O)NS(=O)(=O)C(F)(F)F)cn2C(=O)c1ccc(Cl)cc1 CHEMBL2323490 EC50 0.1 nM
C[C@](O)(COc1ccc(Br)cc1F)C(=O)N1CCc2c(C#N)cccc21 CHEMBL3233072 EC50 0.11 nM
COc1ccc2c(c1)c(CC(=O)O)c(C)n2C(=O)c1ccc(Cl)cc1 CHEMBL6 EC50 0.14 nM
COc1ccc2c(c1)c(C)c(CCC(=O)NS(C)(=O)=O)n2C(=O)c1ccc(Cl)cc1 CHEMBL2323511 EC50 0.14 nM
Cn1c(C#N)ccc1-c1c(F)cc(O)cc1F CHEMBL4095364 EC50 0.14 nM
COc1ccc2c(c1)c(C)c(CCC(=O)O)n2C(=O)c1ccc(Cl)cc1 CHEMBL2323507 EC50 0.15 nM
C[C@](O)(COc1ccccc1C#N)C(=O)N1CCc2c(C#N)cccc21 CHEMBL3238287 EC50 0.15 nM
N#Cc1ccc(C(O)(C2CC2)C(F)(F)F)cc1C(F)(F)F CHEMBL3819048 pEC50 0.1585 nM
CO[C@@H]1C(c2ccc(C#N)c(Cl)c2C)=NN2CC[C@@H](F)[C@@H]12 CHEMBL3326461 EC50 0.16 nM
Cn1c(C#N)ccc1-c1c(Cl)cc(O)cc1Cl CHEMBL4074555 EC50 0.17 nM
C[C@H]1CCCN1c1ccc(C#N)c2ccccc12 CHEMBL3402221 EC50 0.19 nM
Cc1c(N2CC[C@H](O)[C@@H]2C)ccc(C#N)c1Cl CHEMBL4090028 IC50 0.19 nM
Cc1c(C(O)(C2CC2)C(F)(F)F)ccc(C#N)c1Cl CHEMBL3818497 pEC50 0.1995 nM
N#Cc1ccc(C(O)(C2CC2)C(F)(F)F)c(Cl)c1Cl CHEMBL3818619 pEC50 0.1995 nM
Cc1c(C(O)(C2CCC2)C(F)(F)F)ccc(C#N)c1C(F)(F)F CHEMBL3819648 pEC50 0.1995 nM
C[C@]12CCC3=C4CCC(=O)C=C4CC[C@H]3[C@@H]1CC[C@@H]2O CHEMBL2311179 IC50 0.2 nM
CCCCCCCCCCCC[C@H]1C[C@@]2(C)C(CC[C@@H]2O)C2CCC3=CC(=O)CCC3=C21 CHEMBL189306 IC50 0.2 nM
O=c1cc(C(F)(F)F)c2cc(N(CC(F)(F)F)CC(F)(F)F)ccc2[nH]1 CHEMBL436784 EC50 0.2 nM
O=c1cc(C(F)(F)F)c2cc(N(CC(F)F)CC(F)(F)F)ccc2[nH]1 CHEMBL440980 EC50 0.2 nM
COc1c(C(=O)OC(F)(F)F)ccc2oc(=O)c3c(ccc4[nH]c(=O)cc(C)c43)c12 CHEMBL256769 IC50 0.2 nM
COc1c(O)ccc2oc(=O)c3c(ccc4[nH]c(=O)cc(C)c43)c12 CHEMBL427898 IC50 0.2 nM
Cc1c(/N=C2\O[C@H](C(F)(F)F)[C@@H]3[C@@H](O)CCN23)ccc(C#N)c1Cl CHEMBL484727 Ki 0.2 nM
CC1(C)NC(=S)N(c2ccc(C#N)c(Cl)c2)C1=O CHEMBL1288329 EC5 0.2 nM
Cc1c(N2CC[C@](C)(O)[C@@H]2C)ccc(C#N)c1Cl CHEMBL4060271 IC50 0.2 nM
Cc1c(/N=C2\O[C@@H](C(F)(F)F)[C@@H]3[C@@H](O)CCN23)ccc(C#N)c1Cl CHEMBL484726 EC50 0.2 nM
CC[C@H]1CCCN1c1ccc(C#N)c2ccccc12 CHEMBL3402224 EC50 0.24 nM
CCC(=O)O[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C CHEMBL1170 Ki 0.25 nM
C[C@](O)(COc1ccc(Cl)cc1Cl)C(=O)N1CCc2c(C#N)cccc21 CHEMBL3233071 EC50 0.25 nM
C[C@H]1[C@@H](O)CCN1c1ccc(C#N)c2ccccc12 CHEMBL3402228 EC50 0.25 nM
Cc1c(N2[C@@H]3CC[C@H]2C[C@@](C)(O)C3)ccc(C#N)c1Cl CHEMBL3084681 pEC50 0.2512 nM
Cc1c(C(O)(c2ccco2)C(F)(F)F)ccc(C#N)c1C(F)(F)F CHEMBL3819080 pEC50 0.2512 nM
Cc1c(C(O)(C(C)C)C(F)(F)F)ccc(C#N)c1C(F)(F)F CHEMBL3819303 pEC50 0.2512 nM
C[C@](O)(COc1ccc(Cl)cc1F)C(=O)N1CCc2c(C#N)cccc21 CHEMBL3233070 EC50 0.28 nM
Cc1c(N2CC[C@](C)(O)[C@@H]2C)ccc(C#N)c1F CHEMBL4092535 IC50 0.29 nM
CC[C@@H]1c2cc3c(C(F)(F)F)cc(=O)oc3cc2NC[C@H]1C CHEMBL2112312 IC50 0.3 nM
C[C@](O)(CBr)C(=O)Nc1ccc([N+](=O)[O-])c(C(F)(F)F)c1 CHEMBL296323 Ki 0.3 nM
C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]21C CHEMBL1445 EC50 0.3 nM
Cc1cc(=O)[nH]c2ccc3c(c12)COc1cccc(CO)c1-3 CHEMBL257151 IC50 0.3 nM
Cc1c(/N=C2\OC[C@@H]3[C@@H](O)CCN23)ccc(C#N)c1Cl CHEMBL520174 Ki 0.3 nM
Cc1c(/N=C2\O[C@@H](C(F)(F)F)[C@@H]3[C@H](O)CCN23)ccc(C#N)c1Cl CHEMBL484728 Ki 0.3 nM
CO[C@@H]1C(c2ccc(C#N)c(Cl)c2C)=NN2CC(F)(F)C[C@@H]12 CHEMBL3326466 EC50 0.3 nM
C[C@H]1[C@H](O)CCN1c1ccc(C#N)c2ccccc12 CHEMBL3402229 EC50 0.32 nM
C[C@@H]1N(c2ccc(C#N)c(Cl)c2)CC[C@]1(C)O CHEMBL4068946 IC50 0.32 nM
C[C@](O)(COc1ccc(Br)cc1)C(=O)N1CCc2c(C#N)cccc21 CHEMBL3238280 EC50 0.34 nM
Cn1c(C#N)ccc1-c1ccc(O)cc1F CHEMBL4095883 EC50 0.34 nM
N#Cc1ccc(-c2ccc(O)cc2F)[nH]1 CHEMBL5193931 EC50 0.34 nM
CC[C@H]1[C@@H](O)[C@H](C)C(=O)N1c1ccc(C#N)c(Cl)c1 CHEMBL4100995 EC50 0.39 nM
N#Cc1ccc(C(O)(C2CC2)C(F)(F)F)cc1Cl CHEMBL3818577 pEC50 0.3981 nM
O=C1[C@@H]2C3C=CC(CC3)[C@@H]2C(=O)N1c1cccc(C(F)(F)F)c1 CHEMBL182412 IC50 0.4 nM
CCN(CC(F)(F)F)c1ccc2nc(O)cc(C(F)(F)F)c2c1 CHEMBL217769 EC50 0.4 nM
O=c1cc(C(F)(F)F)c2cc(N(CC(F)F)CC(F)(F)Cl)ccc2[nH]1 CHEMBL393664 EC50 0.4 nM
O=c1cc(C(F)(F)F)c2cc(N(CC(F)F)CC(F)F)ccc2[nH]1 CHEMBL237045 EC50 0.4 nM
O=c1cc(C(F)F)c2cc(N(CC(F)(F)F)CC(F)(F)F)ccc2[nH]1 CHEMBL238330 Ki 0.4 nM
C[C@](O)(COc1ccc(F)cc1Br)C(=O)N1CCc2c(C#N)cccc21 CHEMBL3238289 EC50 0.4 nM
CO[C@@H]1C(c2ccc(C#N)c(Cl)c2C)=NN2CC[C@@H](O)[C@@H]12 CHEMBL3326458 EC50 0.4 nM
C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@@]43C)[C@@H]1CC[C@@H]2O CHEMBL386630 Kd 0.4 nM
Cc1c(N2C(=O)[C@@H]3[C@H](O)CCN3S2(=O)=O)ccc(C#N)c1Cl CHEMBL233773 Ki 0.45 nM
Cc1nn(-c2ccc(C#N)c(Cl)c2)c(C)c1Cc1ccc(F)cc1 CHEMBL1957612 IC50 0.47 nM
Cc1c(N[C@@H]2CCC[C@@]2(C)O)ccc(C#N)c1Cl CHEMBL3764185 EC50 0.499 nM
O=C1[C@@H]2C3C=CC(C3)[C@@H]2C(=O)N1c1ccc([N+](=O)[O-])c2ccccc12 CHEMBL181571 Ki 0.5 nM
O=C1[C@@H]2C3C=CC(CC3)[C@@H]2C(=O)N1c1ccc([N+](=O)[O-])c2ccccc12 CHEMBL361445 Ki 0.5 nM
CC1=C(c2ccc(C#N)c(Cl)c2C)C(=O)N2CC[C@H](O)[C@@H]12 CHEMBL395483 Ki 0.5 nM
O=c1cc(C(F)(F)F)c2cc(N(CCCl)CC(F)(F)F)ccc2[nH]1 CHEMBL237474 EC50 0.5 nM
O=c1cc(Br)c2cc(N(CC(F)(F)F)CC(F)(F)F)ccc2[nH]1 CHEMBL238332 Ki 0.5 nM
O=c1cc(Cl)c2cc(N(CC(F)(F)F)CC(F)(F)F)ccc2[nH]1 CHEMBL238331 Ki 0.5 nM
CO[C@@H]1C(c2ccc(C#N)c(Cl)c2C)=NN2CC[C@H](O)[C@@H]12 CHEMBL3326454 EC50 0.5 nM
Cc1c(C(O)(c2cocn2)C(F)(F)F)ccc(C#N)c1C(F)(F)F CHEMBL3818235 pEC50 0.5012 nM
C[C@@](O)(COc1ccc(C#N)cc1)C(=O)Nc1ccc(C#N)c(I)c1 CHEMBL469759 Ki 0.54 nM
C[C@](O)(COc1ccc(C#N)cc1)C(=O)Nc1ccc(C#N)c(C(F)(F)F)c1 CHEMBL1738889 Ki 0.55 nM
O=C1[C@@H]2C3C=CC(C3)[C@@H]2C(=O)N1c1ccc(Br)c(C(F)(F)F)c1 CHEMBL361222 Ki 0.6 nM
Cc1c(N2C(=O)[C@@H]3[C@H](O)CCN3C2=O)ccc(C#N)c1Br CHEMBL398226 EC50 0.6 nM
C[C@H]1CC2(CCN(c3ccc(C(=O)N4CCN(C5CN(c6ccc7c(c6)C(=O)N(C6CCC(=O)NC6=O)C7=O)C5)CC4)cc3)CC2)CN1c1ccc(C#N)c(Cl)c1 CHEMBL5404267 EC50 0.6 nM
COc1ccc(OC[C@](C)(O)C(=O)N2CCc3c(C#N)cccc32)c(Cl)c1 CHEMBL3233069 EC50 0.61 nM
N#Cc1ccc(C(O)(C2CCC2)C(F)(F)F)c(Cl)c1Cl CHEMBL3819640 pEC50 0.631 nM
CC#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@@H](c3ccc(N(C)C)cc3)C[C@@]21C CHEMBL1276308 Ki 0.65 nM
CN1C(=O)C(F)=C[C@]2(C)[C@H]3CC[C@]4(C)[C@@H](C(=O)NCc5nc6cccnc6[nH]5)CC[C@H]4[C@@H]3CC[C@@H]12 CHEMBL3221237 EC50 0.65 nM
Cc1c(N2C(=O)[C@@H]3[C@H](O)CCN3C2=O)ccc(C#N)c1Cl CHEMBL229264 EC50 0.7 nM
Cc1c(C#N)ccc(N2C(=O)[C@@H]3[C@H](O)CCN3C2=O)c1Cl CHEMBL231122 Ki 0.7 nM
CC[C@H]1[C@@H]2[C@H](O)CCN2C(=O)N1c1ccc(C#N)c(Cl)c1C CHEMBL229160 Ki 0.7 nM
Cc1c(/N=C2\O[C@@H](C(C)C)[C@@H]3[C@H](O)CCN23)ccc(C#N)c1Cl CHEMBL483745 Ki 0.7 nM
Cc1c(N2C(=O)C3[C@H](O)CCN3C2=O)ccc(C#N)c1Cl CHEMBL5184779 EC50 0.7 nM
Cc1c(C(O)(C(C)C)C(F)(F)F)ccc(C#N)c1Cl CHEMBL3818208 pEC50 0.7943 nM
CC(C)C(O)(c1ccc(C#N)c(Cl)c1Cl)C(F)(F)F CHEMBL3818367 pEC50 0.7943 nM
CCCCCCCCCC[C@H]1C[C@@]2(C)C(CC[C@@H]2O)C2CCC3=CC(=O)CCC3=C21 CHEMBL186254 IC50 0.8 nM
Cc1cc(=O)[nH]c2ccc(N(CC(F)(F)F)CC(F)(F)F)cc12 CHEMBL238122 EC50 0.8 nM
COc1ccc(-c2ccc(C#N)c(C(F)(F)F)c2)cc1 CHEMBL235159 IC50 0.8 nM
CCCN(CC1CC1)c1cc(C(F)(F)F)c(C#N)cn1 CHEMBL398431 IC50 0.8 nM
COc1ccc2oc(=O)c3c(ccc4[nH]c(=O)cc(C)c43)c2c1 CHEMBL258397 IC50 0.8 nM
Cc1c(/N=C2\OC[C@@H]3[C@H](O)CCN23)ccc(C#N)c1Cl CHEMBL484919 Ki 0.8 nM
CN1C(=S)N(c2ccc(Cl)c(Cl)c2)C(=O)[C@@]1(C)c1ccc(O)cc1 CHEMBL2177230 Activity 0.8 nM
C[C@]12COC(=O)C[C@@H]1CC[C@@H]1[C@@H]2CC[C@@]2(C)[C@H]1CC[C@]2(C)O CHEMBL1200436 IC50 0.808 nM
CCCCCCCC[C@H]1C[C@@]2(C)C(CC[C@@H]2O)C2CCC3=CC(=O)CCC3=C21 CHEMBL186467 IC50 0.9 nM
Cc1c(N2C(=O)N3CC[C@H](O)[C@H]3[C@@H]2C(F)(F)F)ccc(C#N)c1Cl CHEMBL375918 Ki 0.9 nM
CC[C@H]1[C@@H]2[C@@H](O)CCN2C(=O)N1c1ccc(C#N)c(Cl)c1C CHEMBL229861 Ki 0.9 nM
CC(C)N(CC(F)(F)F)c1ccc2[nH]c(=O)cc(C(F)(F)F)c2c1 CHEMBL237262 EC50 0.9 nM
C[C@@H]1COc2cc3[nH]c(=O)cc(C(F)(F)F)c3cc2N1CC(F)(F)F CHEMBL224263 Ki 0.9 nM
CN1C(=O)N(c2ccc(C#N)c(C(F)(F)F)c2)C(=O)[C@@]1(C)c1ccc(O)cc1 CHEMBL2177238 Activity 0.9 nM
CN1C(=O)N(c2ccc(C#N)c(C(F)(F)F)c2)C(=O)C1(CO)c1ccc(O)cc1 CHEMBL2178103 Activity 0.9 nM
CCc1c(C)c2c3c(Cl)cc(=O)[nH]c3ccc2n1CC(F)(F)F CHEMBL5170697 Ki 0.9 nM
C[C@H]1COc2cc3[nH]c(=O)cc(C(F)(F)F)c3cc2N1CC(F)(F)F CHEMBL227088 Ki 0.9 nM
C[C@@]1(c2ccc(O)cc2)NC(=O)N(c2ccc(C#N)c(C(F)(F)F)c2)C1=O CHEMBL5192412 IC50 0.9 nM
COCCO[C@@H]1C(c2ccc(C#N)c(Cl)c2C)=NN2CC[C@H](O)[C@@H]12 CHEMBL3326457 EC50 0.93 nM
Cc1nn(-c2ccc(C#N)c(C(F)(F)F)c2)c(C)c1Cc1ccc(F)cc1 CHEMBL1957613 IC50 0.95 nM
CCC1CCNc2cc3oc(=O)cc(C(F)(F)F)c3cc21 CHEMBL6843 IC50 1.0 nM
CC1CCNc2cc3oc(=O)cc(C(F)(F)F)c3cc21 CHEMBL415289 IC50 1.0 nM
CCC1CCc2cc3c(C(F)(F)F)cc(=O)oc3cc2N1 CHEMBL266473 IC50 1.0 nM
CC1(C)CCc2cc3c(C(F)(F)F)cc(=O)oc3cc2N1 CHEMBL7289 IC50 1.0 nM
O=c1cc(C(F)(F)F)c2cc3c(cc2o1)NCCC3 CHEMBL268098 IC50 1.0 nM
CCC1Nc2cc3oc(=O)cc(C(F)(F)F)c3cc2CC1C CHEMBL6654 EC50 1.0 nM
O=C1[C@H]2[C@H]3CC[C@H](C3)N2C(=O)N1c1ccc([N+](=O)[O-])c2ccccc12 CHEMBL185880 Ki 1.0 nM
O=C1[C@H]2[C@@H]3CC[C@@H](C3)N2C(=O)N1c1ccc([N+](=O)[O-])c2ccccc12 CHEMBL384533 Ki 1.0 nM
N#Cc1ccc(N2C(=O)[C@@H]3[C@H](O)CCN3C2=O)c(F)c1Cl CHEMBL394592 EC50 1.0 nM
Cc1c(N2C(=O)N3CC[C@@H](O)[C@H]3[C@@H]2C(F)(F)F)ccc(C#N)c1Cl CHEMBL229210 Ki 1.0 nM
O=c1ccc2cc(N(CC(F)(F)F)CC(F)(F)F)ccc2[nH]1 CHEMBL391798 IC50 1.0 nM
CC[C@@H]1COc2c(ccc3[nH]c(=O)cc(C(F)(F)F)c23)N1CC(F)(F)F CHEMBL250897 EC50 1.0 nM
CC12CCC(C)(O1)[C@H]1C(=O)N(c3ccc(C#N)c(I)c3)C(=O)[C@H]12 CHEMBL403668 Ki 1.0 nM
CC1(C)NC(=S)N(c2ccc(C#N)c(C(F)(F)F)c2)C1=O CHEMBL1290317 EC5 1.0 nM
CCO[C@@H]1C(c2ccc(C#N)c(Cl)c2C)=NN2CC[C@H](O)[C@@H]12 CHEMBL3326455 EC50 1.0 nM
N#Cc1ccc(N2CCC[C@@H]2C#N)c2ccccc12 CHEMBL3402227 IC50 1.0 nM
C[C@]12O[C@@](C)(C[C@H]1NS(=O)(=O)c1ccccc1F)[C@H]1C(=O)N(c3ccc(C#N)c(C(F)(F)F)c3)C(=O)[C@H]12 CHEMBL3623125 Ki 1.0 nM
C[C@]12O[C@@](C)(C[C@H]1NS(=O)(=O)c1ccccc1)[C@H]1C(=O)N(c3ccc(C#N)c(C(F)(F)F)c3)C(=O)[C@H]12 CHEMBL3623124 IC50 1.0 nM
C[C@@H]1C(=O)N(c2ccc(C#N)c(Cl)c2)[C@@H](C)[C@H]1O CHEMBL4074501 EC50 1.0 nM
Cc1c(N2C3CCC2CC(C)(O)C3)ccc(C#N)c1Cl CHEMBL3410856 IC50 1.0 nM
N#Cc1ccc(N2CCC[C@@H]2[C@@H](O)C(F)(F)F)cc1C(F)(F)F CHEMBL5170587 Ki 1.0 nM
CC(=O)O[C@]1(C(C)=O)CC[C@H]2[C@@H]3C[C@H](C)C4=CC(=O)CC[C@]4(C)[C@H]3CC[C@@]21C CHEMBL717 Kd 1.0 nM
N#Cc1ccc(O[C@H]2CC[C@H](NC(=O)c3ccc(N4CCC(CN5CCN(c6cc7c(cc6F)C(=O)N(C6CCC(=O)NC6=O)C7=O)CC5)CC4)nn3)CC2)cc1Cl CHEMBL4862963 DC50 1.0 nM
C=C1CC[C@H](O)C/C1=C/C=C1\CCCC2(C)C1CCC2C(C)/C=C/C(C)C(C)C CHEMBL50241 Ki 1.1 nM
Cc1cccc([C@@H]2COc3cc4[nH]c(=O)cc(C(F)(F)F)c4cc3N2CC(F)(F)F)c1 CHEMBL257379 Ki 1.1 nM
Cc1cc(=O)[nH]c2ccc3c4c(C(=O)OC(C)(C)C)cccc4oc(=O)c3c12 CHEMBL401711 EC50 1.1 nM
O=c1cc(C(F)(F)F)c2c3c(ccc2[nH]1)-c1c(O)cccc1OC3 CHEMBL253535 IC50 1.1 nM
C=C[C@@](O)(c1nc2cc(Cl)c(Cl)cc2[nH]1)C(F)(F)F CHEMBL467790 Ki 1.1 nM
Cc1cc(F)ccc1OC[C@](C)(O)C(=O)N1CCc2c(C#N)cccc21 CHEMBL3238290 EC50 1.1 nM
C[C@H]1[C@@H](O)C(F)(F)C(=O)N1c1ccc(C#N)c(Cl)c1 CHEMBL4063939 IC50 1.1 nM
CC(C)(C)OC(=O)c1cccc2oc(=O)c3c(ccc4[nH]c(=O)cc(C(F)(F)F)c43)c12 CHEMBL5187916 EC50 1.1 nM
CCN1CCOc2cc3[nH]c(=O)cc(C(F)(F)F)c3cc21 CHEMBL224204 Ki 1.2 nM
COc1c(O)ccc2c1-c1ccc3[nH]c(=O)cc(C)c3c1CO2 CHEMBL427731 IC50 1.2 nM
C[C@H]1[C@@H](CO)CCN1c1ccc(C#N)c2ccccc12 CHEMBL3402231 EC50 1.2 nM
N#Cc1ccc(C(O)(c2ccco2)C(F)(F)F)cc1C(F)(F)F CHEMBL3818634 pEC50 1.259 nM
N#Cc1ccc(C(O)(c2cocn2)C(F)(F)F)cc1C(F)(F)F CHEMBL3818224 pEC50 1.259 nM
Cc1c(N2C(=O)[C@@H]3[C@H](O)CCN3C2=O)ccc(C#N)c1F CHEMBL390849 Ki 1.3 nM
CCCN(CC(F)(F)F)c1ccc2[nH]c(=O)cc(C(F)(F)F)c2c1 CHEMBL237261 EC50 1.3 nM
O=c1cc(C(F)(F)F)c2cc3c(cc2[nH]1)OCC(C(F)F)N3CC(F)(F)F CHEMBL256326 EC50 1.3 nM
O=c1cc(C(F)(F)F)c2cc3c(cc2[nH]1)OC[C@@H](c1ccccc1)N3CC(F)(F)F CHEMBL402835 Ki 1.3 nM
CCCCN(CCCC)c1ccc(/C=C2\C(=O)ON=C2c2ccccc2)cc1 CHEMBL89136 Kd 1.4 nM
O=C1ON=C(c2ccccc2F)/C1=C/c1ccc(N2CCCC2)cc1 CHEMBL89437 Kd 1.4 nM
O=C1ON=C(c2ccc(F)cc2)/C1=C/c1ccc(N2CCCC2)cc1 CHEMBL330478 Kd 1.4 nM
O=C1ON=C(c2ccc(O)cc2)/C1=C/c1ccc(N2CCCC2)cc1 CHEMBL315964 Kd 1.4 nM
O=c1cc(C(F)(F)F)c2cc3c(cc2[nH]1)OCCN3CC1CC1 CHEMBL227784 EC50 1.4 nM
Cc1c(C#N)c(-c2ccc(C#N)cc2)c(C)n1Cc1ccccc1 CHEMBL1934442 IC50 1.4 nM
CO[C@@H]1C(c2ccc(C#N)c(Cl)c2C)=NN2C[C@@H](F)C[C@@H]12 CHEMBL3326464 EC50 1.4 nM
CC(C)[C@H]1CCCN1c1ccc(C#N)c2ccccc12 CHEMBL3402225 IC50 1.4 nM
C[C@H]1[C@@H](C(C)(C)O)CCN1c1ccc(C#N)c2ccccc12 CHEMBL3402232 IC50 1.4 nM
Cn1c(C#N)ccc1-c1ccc(O)cc1Cl CHEMBL4088158 IC50 1.4 nM
Cc1nn(-c2ccc(C#N)c(C(F)(F)F)c2)c(C)c1Cc1ccc(C(=O)O)cc1 CHEMBL4227715 IC50 1.4 nM
Cc1c(C#N)c(-c2ccc(C#N)cc2)c(C)n1Cc1ccc(C(=O)O)cc1 CHEMBL4226259 IC50 1.4 nM
CCCN(CCC)c1ccc2[nH]c(=O)cc(C(F)(F)F)c2c1 CHEMBL442240 EC50 1.5 nM
O=C1[C@@H]2[C@H](O)CCN2C(=O)N1c1ccc([N+](=O)[O-])c2ccccc12 CHEMBL220359 Ki 1.5 nM
O=C1[C@H]2C[C@@H](O)CN2C(=O)N1c1ccc([N+](=O)[O-])c2ccccc12 CHEMBL219198 Ki 1.5 nM
N#Cc1ccc(N2C(=O)[C@@H]3[C@H](O)CCN3C2=O)cc1Cl CHEMBL230052 Ki 1.5 nM
Cc1c(N2C(=O)N3CC[C@H](O)[C@H]3[C@@H]2C)ccc(C#N)c1Cl CHEMBL229860 Ki 1.5 nM
C[C@@H]1CC[C@H]([C@@H](O)C(F)(F)F)N1c1ccc2[nH]c(=O)cc(C(F)(F)F)c2c1 CHEMBL467888 Ki 1.5 nM
Cc1c(N2C(=O)N(C)C(C)(c3ccc(O)cc3)C2=O)ccc(C#N)c1Cl CHEMBL2177241 Activity 1.5 nM
COc1cc(N2C(=O)N(C)[C@](C)(c3ccc(O)cc3)C2=O)ccc1C#N CHEMBL2177240 Activity 1.5 nM
CO[C@@H]1C(c2ccc(C#N)c(Cl)c2C)=NN2CC[C@H](F)[C@@H]12 CHEMBL3326460 EC50 1.5 nM
CCCC[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@@H](c3ccc(N(C)C)cc3)C[C@@]21C CHEMBL4174812 EC50 1.5 nM
N#Cc1ccc(N2[C@@H]3CC[C@H]2C[C@@H](O)C3)c2ccccc12 CHEMBL3084525 pEC50 1.585 nM
N#Cc1ccc(C(O)(C2CCC2)C(F)(F)F)cc1Cl CHEMBL3819102 pEC50 1.585 nM
Cc1c(C#N)ccc(C(O)(C2CC2)C(F)(F)F)c1C CHEMBL3818854 pEC50 1.585 nM
N#Cc1ccc(C(O)(C2CCC2)C(F)(F)F)cc1C(F)(F)F CHEMBL3819393 pEC50 1.585 nM
Cc1c(C(O)(C(F)(F)F)C(F)(F)F)ccc(C#N)c1C(F)(F)F CHEMBL3818542 pEC50 1.585 nM
CC[C@@H]1[C@@H]2[C@@H](O)CCN2C(=O)N1c1ccc(C#N)c(Cl)c1C CHEMBL229916 Ki 1.6 nM
O=c1cc(C(F)(F)F)c2cc(N(CC(Cl)Cl)CC(F)(F)F)ccc2[nH]1 CHEMBL428026 EC50 1.6 nM
CN1C(=O)N(c2ccc(C#N)c(C(F)(F)F)c2)C(=O)C1(C)c1ccc(O)cc1 CHEMBL2177236 Activity 1.6 nM
C[C@](O)(CSc1ccc(NC(=O)CCl)cc1)C(=O)Nc1ccc(C#N)c(C(F)(F)F)c1 CHEMBL333745 Ki 1.65 nM
O=C1C2CCCN2C(=O)N1c1ccc([N+](=O)[O-])c2ccccc12 CHEMBL374121 Ki 1.7 nM
Cc1c(C#N)ccc(N2C(=O)[C@@H]3[C@H](O)CCN3C2=O)c1C CHEMBL389607 EC50 1.7 nM
C[C@](O)(COc1ccc(Cl)c(F)c1)C(=O)Nc1ccc(C#N)c(C(F)(F)F)c1 CHEMBL512283 Ki 1.7 nM
C[C@](O)(COc1ccccc1C(F)(F)F)C(=O)N1CCc2c(C#N)cccc21 CHEMBL3238286 EC50 1.7 nM
CCS(=O)(=O)N[C@@H]1C[C@]2(C)O[C@]1(C)[C@@H]1C(=O)N(c3ccc(C#N)c(C(F)(F)F)c3)C(=O)[C@@H]12 CHEMBL3623127 Ki 1.7 nM
CCS(=O)(=O)N[C@@H]1C[C@@]2(C)O[C@]1(C)[C@@H]1C(=O)N(c3ccc(C#N)c(C(F)(F)F)c3)C(=O)[C@@H]12 CHEMBL3932464 Ki 1.7 nM
CC(C)(C)CN(CC(F)(F)F)c1ccc2[nH]c(=O)cc(C(F)(F)F)c2c1 CHEMBL237472 EC50 1.8 nM
C[C@](O)(COc1ccc(C(F)(F)F)cc1)C(=O)N1CCc2c(C#N)cccc21 CHEMBL3238281 EC50 1.8 nM
C[C@](O)(COc1ccc(C#N)cc1)C(=O)N1CCc2c(C#N)cccc21 CHEMBL3238285 EC50 1.8 nM
Oc1cc(C(F)(F)F)c2cc(N(CC3CC3)CC3CC3)ccc2n1 CHEMBL217324 EC50 1.9 nM
CC1COc2cc3[nH]c(=O)cc(C(F)(F)F)c3cc2N1CC1CC1 CHEMBL227394 EC50 1.9 nM
Cc1c(N2C(=O)N3CC[C@H](O)[C@H]3[C@H]2C(F)(F)F)ccc(C#N)c1Cl CHEMBL389250 Ki 1.9 nM
Cc1c(/N=C2\N(C)C[C@@H]3[C@H](O)CCN23)ccc(C#N)c1Cl CHEMBL519169 Ki 1.9 nM
N#Cc1ccc(C(O)(c2nccs2)C(F)(F)F)cc1C(F)(F)F CHEMBL3819324 pEC50 1.995 nM
N#Cc1ccc(C(O)(c2cscn2)C(F)(F)F)cc1C(F)(F)F CHEMBL3818942 pEC50 1.995 nM
CCC(O)(c1ccc(C#N)c(Cl)c1C)C(F)(F)F CHEMBL3819094 pEC50 1.995 nM
C[C@H]1CNc2cc3nc(O)cc(C(F)(F)F)c3cc2C1CCC(F)(F)F CHEMBL281945 Ki 2.0 nM
Oc1cc(C(F)(F)F)c2cc3c(cc2n1)NC[C@@H]1CCCC[C@H]31 CHEMBL431493 Ki 2.0 nM
Oc1cc(C(F)(F)F)c2cc3c(cc2n1)NC[C@H]1CCCC[C@H]31 CHEMBL25802 EC50 2.0 nM
CC[C@H]1c2cc3c(C(F)(F)F)cc(=O)oc3cc2NC[C@H]1C CHEMBL2112311 IC50 2.0 nM
O=c1cc(C(F)(F)F)c2cc3c(cc2o1)NCCC3C(F)(F)F CHEMBL267270 EC50 2.0 nM
O=C1[C@@H]2C3CCC(C3)[C@@H]2C(=O)N1c1cccc(C(F)(F)F)c1 CHEMBL367364 Ki 2.0 nM
O=C1[C@@H]2C3CCC(C3)[C@@H]2C(=O)N1c1ccc([N+](=O)[O-])c(C(F)(F)F)c1 CHEMBL178333 Ki 2.0 nM
O=C1[C@@H]2C3C=CC(C3)[C@@H]2C(=O)N1c1ccc(F)c(Cl)c1 CHEMBL180859 Ki 2.0 nM
CC(C)(O)C(=O)Nc1ccc([N+](=O)[O-])c(C(F)(F)F)c1 CHEMBL491 Ki 2.0 nM
CC[C@H]1C[C@@]2(C)C(CC[C@@H]2O)C2CCC3=CC(=O)CCC3=C21 CHEMBL184228 IC50 2.0 nM
Cc1c(N2C[C@@H]3[C@H](O)CCN3C2=O)ccc(C#N)c1Cl CHEMBL229808 Ki 2.0 nM
CC(C)c1cc(=O)[nH]c2ccc(N(CC(F)(F)F)CC(F)(F)F)cc12 CHEMBL238124 IC50 2.0 nM
CC(C)C(O)(c1nc2cc(Cl)c(Cl)cc2[nH]1)C(F)(F)F CHEMBL401458 IC50 2.0 nM
O=c1cc(C(F)(F)F)c2cc3c(cc2[nH]1)OC[C@H](C(F)(F)F)N3CC(F)(F)F CHEMBL401805 EC50 2.0 nM
COC[C@@H]1COc2cc3[nH]c(=O)cc(C(F)(F)F)c3cc2N1CC(F)(F)F CHEMBL402039 EC50 2.0 nM
COc1ncc(/C=C2\C[C@H]3[C@@H]4CC[C@H]5N(C)C(=O)C=C[C@]5(C)[C@H]4CC[C@]3(C)[C@H]2O)cn1 CHEMBL559878 EC50 2.0 nM
C=CCN1C(=O)N(c2ccc(C#N)c(C(F)(F)F)c2)C(=O)C1(C)c1ccc(O)cc1 CHEMBL2177232 Activity 2.0 nM
CN1C(=S)N(c2ccc(Cl)c(Cl)c2)C(=O)C1(C)c1ccc(O)cc1 CHEMBL2177229 Activity 2.0 nM
C[C@]12O[C@@](C)(C[C@H]1NS(=O)(=O)c1cccnc1)[C@H]1C(=O)N(c3ccc(C#N)c(C(F)(F)F)c3)C(=O)[C@H]12 CHEMBL3623126 Ki 2.0 nM
C[C@@]12[C@@H]3C=C[C@@H](C3)[C@@H]1CN(c1ccc(C#N)c(C(F)(F)F)c1)S2(=O)=O CHEMBL3898284 Ki 2.0 nM
N#CCC(O)(c1nc2cc(Cl)c(Cl)cc2[nH]1)C(F)(F)F CHEMBL246006 IC50 2.0 nM
CCN(CC)c1ccc2nc(O)cc(C(F)(F)F)c2c1 CHEMBL277378 EC50 2.1 nM
Cc1c(N2C(=O)N3CC[C@@H](O)[C@H]3[C@H]2C(F)(F)F)ccc(C#N)c1Cl CHEMBL229211 EC50 2.1 nM
COc1cc(N2C(=O)N(C)C(C)(c3ccc(O)cc3)C2=O)ccc1C#N CHEMBL2177239 Activity 2.1 nM
CCN(c1ccc2nc(O)cc(C(F)(F)F)c2c1)C(C)C CHEMBL217402 EC50 2.2 nM
Cc1c(N2C(=O)[C@@H]3[C@H](O)CCN3C2=O)ccc(C#N)c1C#N CHEMBL231014 EC50 2.2 nM
Cc1c(N2C[C@@H]3[C@H](O)CC[C@@H]3C2=O)ccc(C#N)c1Cl CHEMBL389077 Ki 2.2 nM
Cc1cc(-c2ccc([N+](=O)[O-])cc2)c(C)n1Cc1ccccc1 CHEMBL1934438 IC50 2.2 nM
C[C@H]1C(=O)CCN1c1ccc(C#N)c2ccccc12 CHEMBL3402230 EC50 2.2 nM
CCC1COc2cc3[nH]c(=O)cc(C(F)(F)F)c3cc2N1CC1CC1 CHEMBL389481 EC50 2.3 nM
N#Cc1ccc(N2C(=O)[C@@H]3[C@H](O)CCN3C2=O)c2ccccc12 CHEMBL425646 EC50 2.3 nM
CC[C@@H]1[C@@H]2[C@H](O)CCN2C(=O)N1c1ccc(C#N)c(Cl)c1C CHEMBL390593 Ki 2.3 nM
C[C@@H](N(CC(F)(F)F)c1ccc2[nH]c(=O)cc(C(F)(F)F)c2c1)C(F)(F)F CHEMBL235127 EC50 2.3 nM
O=c1cc(C(F)(F)F)c2cc(N(CC(F)(F)F)CC(F)(F)C(F)(F)F)ccc2[nH]1 CHEMBL237681 EC50 2.3 nM
Cc1c(/N=C2\O[C@H](C(F)(F)F)[C@@H]3[C@H](O)CCN23)ccc(C#N)c1Cl CHEMBL521329 Ki 2.3 nM
N#Cc1ccc(C(=O)CC(Nc2ccc([N+](=O)[O-])cc2)c2ccsc2)cc1 CHEMBL1163602 Ki 2.3 nM
CCCN1CCOc2cc3[nH]c(=O)cc(C(F)(F)F)c3cc21 CHEMBL227590 EC50 2.4 nM
CSCC[C@@H]1COc2cc3[nH]c(=O)cc(C(F)(F)F)c3cc2N1CC(F)(F)F CHEMBL404483 Ki 2.4 nM
C#CCN1C(=O)N(c2ccc(C#N)c(C(F)(F)F)c2)C(=O)C1(C)c1ccc(O)cc1 CHEMBL2177233 Activity 2.4 nM
C[C@@]12O[C@@](C)(C[C@H]1O)[C@@H]1C(=O)N(c3ccc(C#N)c(I)c3)C(=O)[C@@H]12 CHEMBL5186213 Ki 2.4 nM
CC12C[C@@H](O)C(C)(O1)[C@H]1C(=O)N(c3ccc(C#N)c(I)c3)C(=O)[C@H]12 CHEMBL272574 Ki 2.41 nM
C[C@](O)(COc1ccc(F)cc1)C(=O)N1CCc2c(C#N)cccc21 CHEMBL3238274 EC50 2.5 nM
O=[N+]([O-])c1ccc(N2CCCC2)c2ccccc12 CHEMBL570897 IC50 2.5 nM
N#Cc1ccc(N2CCCC2)c2ccccc12 CHEMBL570898 IC50 2.5 nM
C[C@](O)(CCOc1ccc(F)cc1)C(=O)N1CCc2c(C#N)cccc21 CHEMBL5209205 EC50 2.5 nM
N#Cc1ccc(C(O)(c2ccc(Cl)o2)C(F)(F)F)cc1C(F)(F)F CHEMBL3818412 pEC50 2.512 nM
CCC(O)(c1ccc(C#N)c(Cl)c1Cl)C(F)(F)F CHEMBL3819015 pEC50 2.512 nM
C[C@@H]1CC[C@H](C)N1c1ccc2[nH]c(=O)cc(C(F)(F)F)c2c1 CHEMBL244896 EC50 2.6 nM
O=c1cc(C(F)(F)F)c2cc3c(cc2[nH]1)OC[C@H](CF)N3CC(F)(F)F CHEMBL429311 Ki 2.6 nM
CC[C@@H]1COc2cc3[nH]c(=O)cc(C(F)(F)F)c3cc2N1CC(F)(F)F CHEMBL226558 EC50 2.7 nM
CC1COc2cc3[nH]c(=O)cc(C(F)(F)F)c3cc2N1CC(F)(F)F CHEMBL227440 EC50 2.7 nM
Oc1cc(C(F)(F)F)c2cc(N(CC3CC3)CC(F)(F)F)ccc2n1 CHEMBL267260 EC50 2.8 nM
O=c1cc(C(F)(F)F)c2cc(N(Cc3ccoc3)CC(F)(F)F)ccc2[nH]1 CHEMBL3706930 EC50 2.8 nM
COc1c(OC(C)C)ccc2oc(=O)c3c(ccc4[nH]c(=O)cc(C)c43)c12 CHEMBL256768 IC50 2.8 nM
Cc1c(C(O)(c2ccc(Cl)o2)C(F)(F)F)ccc(C#N)c1C(F)(F)F CHEMBL3819469 pEC50 2.884 nM
Cc1c(N2C(=O)[C@@H]3[C@H](O)CCN3C2=O)ccc(C#N)c1C(F)(F)F CHEMBL230694 Ki 2.9 nM
Cc1c(N2C(=O)N3CC[C@@H](O)[C@H]3[C@@H]2C)ccc(C#N)c1Cl CHEMBL229159 Ki 2.9 nM
O=C(CC(Nc1ccc([N+](=O)[O-])cc1)c1ccco1)c1ccc(Cl)cc1 CHEMBL1163630 IC50 2.9 nM
COc1ccc(OC[C@](C)(O)C(=O)N2CCc3c(C#N)cccc32)c(F)c1 CHEMBL3238295 EC50 2.9 nM
Cc1cc(-c2ccc(C#N)n2C)ccc1O CHEMBL4065842 IC50 2.9 nM
CC(C)C1CCNc2cc3nc(O)cc(C(F)(F)F)c3cc21 CHEMBL27276 EC50 3.0 nM
CC[C@H]1Cc2cc3c(C(F)(F)F)cc(O)nc3cc2N[C@@H]1CC CHEMBL6959 EC50 3.0 nM
O=C1[C@@H]2C3C=CC([C@H]4C[C@@H]34)[C@@H]2C(=O)N1c1ccc([N+](=O)[O-])c2ccccc12 CHEMBL367375 Ki 3.0 nM
CC12CCC(C)(O1)[C@H]1C(=O)N(c3ccc(C#N)c4nsnc34)C(=O)[C@H]12 CHEMBL446626 Ki 3.0 nM
CC12CCC(C)(O1)[C@H]1C(=O)N(c3cc(Cl)cc(Cl)c3)C(=O)[C@H]12 CHEMBL257668 Ki 3.0 nM
CSc1cc(N2C(=O)[C@@H]3[C@H](C2=O)C2(C)CCC3(C)O2)ccc1C#N CHEMBL272509 Ki 3.0 nM
O=C1[C@@H]2C3CCC(O3)[C@@H]2C(=O)N1c1ccc([N+](=O)[O-])c2ccccc12 CHEMBL402807 Ki 3.0 nM
O=c1cc(C(F)(F)F)c2c(ccc3c2oc(=O)c2cccc(O)c23)[nH]1 CHEMBL257751 Ki 3.0 nM
CCN(CC)C(=O)c1cc(N(Cc2ccccc2)c2ccc([N+](=O)[O-])cc2)cn1C CHEMBL481139 Ki 3.0 nM
Cn1cc(N(Cc2ccccc2)c2ccc([N+](=O)[O-])cc2)cc1C(=O)O CHEMBL519112 Ki 3.0 nM
CCC1CCNc2cc3[nH]c(=O)cc(C(F)(F)F)c3cc21 CHEMBL390728 EC50 3.0 nM
Cc1c(N2C(=O)N(C)C(C)(c3ccc(O)cc3)C2=O)ccc(C#N)c1C(F)(F)F CHEMBL2177242 Activity 3.0 nM
CCC(=O)N[C@@H]1C[C@]2(C)O[C@]1(C)[C@@H]1C(=O)N(c3ccc(C#N)c(C(F)(F)F)c3)C(=O)[C@@H]12 CHEMBL3623119 Ki 3.0 nM
CNC(=O)[C@@]12[C@@H]3CC[C@@H](C3)[C@@H]1CN(c1ccc(C#N)c(C(F)(F)F)c1)S2(=O)=O CHEMBL3921315 Ki 3.0 nM
N#Cc1ccc(N2C[C@H]3[C@H]4CC[C@H](C4)[C@@]3(C(N)=O)S2(=O)=O)cc1C(F)(F)F CHEMBL3893320 Ki 3.0 nM
C[C@@]12[C@@H](CN(c3ccc(C#N)c(C(F)(F)F)c3)S1(=O)=O)[C@H]1C[C@H](O)[C@@H]2C1 CHEMBL3920247 Ki 3.0 nM
N#Cc1ccc(N2C[C@H]3[C@H]4CC[C@H](C4)[C@H]3S2(=O)=O)cc1C(F)(F)F CHEMBL3917372 Ki 3.0 nM
C[C@@]12[C@@H]3CC[C@@H](C3)[C@@H]1CN(c1ccc(C#N)c(C(F)(F)F)c1)S2(=O)=O CHEMBL3926358 Ki 3.0 nM
C#C[C@]1(O)C=C[C@H]2[C@@H]3CCC4=CC(=O)CC[C@@H]4[C@H]3CC[C@@]21CC CHEMBL1213583 AC50 3.0 nM
CC(=O)C(C)N(CC(F)(F)F)c1ccc2[nH]c(=O)cc(C(F)(F)F)c2c1 CHEMBL3706931 Ki 3.1 nM
CC(C)(C)CC(O)(c1ccc(C#N)c(Cl)c1Cl)C(F)(F)F CHEMBL3818919 pEC50 3.162 nM
CC(C)CC(O)(c1ccc(C#N)c(Cl)c1Cl)C(F)(F)F CHEMBL3818549 pEC50 3.162 nM
N#Cc1ccc(C(O)(C2CCCC2)C(F)(F)F)cc1Cl CHEMBL3817881 pEC50 3.162 nM
CC(C)CN1CCOc2cc3[nH]c(=O)cc(C(F)(F)F)c3cc21 CHEMBL227645 EC50 3.2 nM
Cc1cc(=O)[nH]c2ccc(N(CC(C)C)CC(F)(F)F)cc12 CHEMBL235346 EC50 3.2 nM
CCOCC1COc2cc3[nH]c(=O)cc(C(F)(F)F)c3cc2N1CC(F)(F)F CHEMBL257396 EC50 3.2 nM
CC[C@@H]1C(=O)N(c2ccc(C#N)c(Cl)c2)[C@@H](C)[C@H]1O CHEMBL4101232 IC50 3.2 nM
C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@@H](c3ccc(N(C)CCOCCO[C@H]4CC[C@@]5(C)[C@@H](C4)C[C@@H](O)[C@@H]4[C@@H]5C[C@H](O)[C@]5(C)[C@@H]([C@H](C)CCC(=O)O)CC[C@@H]45)cc3)C[C@@]21C CHEMBL2096708 Ki 3.3 nM
CCc1c(N2C(=O)[C@@H]3[C@H](O)CCN3C2=O)ccc(C#N)c1C(F)(F)F CHEMBL397217 Ki 3.3 nM
Cc1ccc(N2C(=O)[C@@H]3C4C=CC(C4)[C@@H]3C2=O)cc1C CHEMBL366924 Ki 3.4 nM
Cc1c(C#N)c(-c2ccc(C#N)cc2)c(C)n1Cc1cccnc1 CHEMBL1934443 IC50 3.4 nM
C[C@](O)(COc1ccc(Cl)cc1)C(=O)N1CCc2c(C#N)cccc21 CHEMBL3238277 EC50 3.4 nM
CC[C@H]1[C@H](O)CC(=O)N1c1ccc(C#N)c(Cl)c1 CHEMBL4067691 IC50 3.4 nM
O=C1C2C(O)CCN2C(=O)N1c1ccc([N+](=O)[O-])c2ccccc12 CHEMBL374781 Ki 3.5 nM
O=c1cc(C(F)(F)F)c2cc3c(cc2[nH]1)OCCN3CC(F)(F)F CHEMBL227783 EC50 3.5 nM
O=c1cc(C(F)(F)F)c2c3c(ccc2[nH]1)N(CC1CC1)C(c1ccccc1)CO3 CHEMBL247637 EC50 3.5 nM
C[C@]12CN(c3cc(Cl)ncn3)C[C@](C)(O1)[C@@H]1C(=O)N(c3ccc(C#N)c(C(F)(F)F)c3)C(=O)[C@@H]12 CHEMBL1210152 Ki 3.5 nM
Cc1cc(N2C(=O)[C@@H]3C4C=CC(C4)[C@@H]3C2=O)ccc1Br CHEMBL182236 Ki 3.6 nM
C[C@@H](CCl)N(CC(F)(F)F)c1ccc2[nH]c(=O)cc(C(F)(F)F)c2c1 CHEMBL235347 EC50 3.6 nM
CC[C@H]1[C@@H](O)CC(=O)N1c1ccc(C#N)c(C(F)(F)F)c1 CHEMBL4088914 IC50 3.6 nM
COc1c(C#N)ccc(N2C(=O)[C@@H]3[C@H](O)CCN3C2=O)c1C CHEMBL230695 Ki 3.7 nM
C[C@H](CCl)N(CC(F)(F)F)c1ccc2[nH]c(=O)cc(C(F)(F)F)c2c1 CHEMBL394194 EC50 3.7 nM
CON1C[C@@]2(C)O[C@@](C)(C1)[C@@H]1C(=O)N(c3ccc(C#N)c(C(F)(F)F)c3)C(=O)[C@@H]12 CHEMBL1210910 Ki 3.7 nM
Cc1cc(O)ccc1-c1ccc(C#N)n1C CHEMBL4079377 IC50 3.7 nM
CCCCN(C)c1cc(C(F)(F)F)c(C#N)cn1 CHEMBL249071 IC50 3.8 nM
COC(=O)c1c(-c2ccc([N+](=O)[O-])cc2)c(C)n(Cc2ccccc2)c1C CHEMBL1934434 IC50 3.8 nM
CCC1COc2cc3[nH]c(=O)cc(C(F)(F)F)c3cc2N1CC CHEMBL224207 EC50 3.9 nM
COC(=O)c1c(-c2ccc(C#N)c(C(F)(F)F)c2)c(C)n(Cc2ccccc2)c1C CHEMBL1934441 IC50 3.9 nM
CC[C@H]1[C@@H](O)CC(=O)N1c1ccc(C#N)c(Cl)c1 CHEMBL4072533 IC50 3.9 nM
Cc1c(C(C)(O)C(F)(F)F)ccc(C#N)c1C(F)(F)F CHEMBL3819041 EC50 3.98 nM
Cc1c(C(O)(CC(C)(C)C)C(F)(F)F)ccc(C#N)c1Cl CHEMBL3818688 pEC50 3.981 nM
CC(C)C(O)(c1ccc(C#N)c(Cl)c1)C(F)(F)F CHEMBL3818620 pEC50 3.981 nM
CCC(O)(c1ccc(C#N)c(C(F)(F)F)c1)C(F)(F)F CHEMBL3818789 pEC50 3.981 nM
CN1C(=O)N(c2ccc(C#N)c(C(F)(F)F)c2)C(=O)[C@@]1(O)c1ccccc1 CHEMBL5185723 EC50 3.99 nM
Cn1c(=O)cc(C(F)(F)F)c2cc3c(cc21)N[C@@H]1CCCC[C@H]31 CHEMBL163425 Ki 4.0 nM
Cc1c(N2C(=O)N3CC[C@H](O)[C@H]3[C@H]2C)ccc(C#N)c1Cl CHEMBL229862 Ki 4.0 nM
CC12CCC(C)(O1)[C@H]1C(=O)N(c3cnc(C#N)c(Cl)c3)C(=O)[C@H]12 CHEMBL403213 Ki 4.0 nM
CC(=O)Nc1ccc(OC[C@](C)(O)C(=O)Nc2ccc([N+](=O)[O-])c(C(F)(F)F)c2)cc1 CHEMBL125236 Ki 4.0 nM
CN1C(=S)N(c2ccc(C#N)c(C(F)(F)F)c2)C(=O)C1(C)c1ccc(O)cc1 CHEMBL2177231 Activity 4.0 nM
CC(=O)Nc1ccc(OC[C@@](C)(O)C(=O)Nc2ccc([N+](=O)[O-])c(C(F)(F)F)c2)cc1 CHEMBL511130 Ki 4.0 nM
C[C@@](O)(COc1ccc(C#N)cc1)C(=O)Nc1ccc(C#N)c(C(F)(F)F)c1 CHEMBL4754501 Ki 4.0 nM
O=C(N(CC(F)(F)F)c1ccc2[nH]c(=O)cc(C(F)(F)F)c2c1)C(F)(F)F CHEMBL3706929 IC50 4.1 nM
CCN1c2cc3c(C(F)(F)F)cc(=O)[nH]c3cc2OCC1C CHEMBL227305 Ki 4.2 nM
CCCOCC1COc2cc3[nH]c(=O)cc(C(F)(F)F)c3cc2N1CC(F)(F)F CHEMBL255655 EC50 4.2 nM
O=C1[C@H]2C[C@H](O)CN2C(=O)N1c1ccc([N+](=O)[O-])c2ccccc12 CHEMBL2096842 Ki 4.3 nM
N#Cc1ccc(N2C(=O)[C@@H]3[C@H](O)CCN3C2=O)c(F)c1F CHEMBL231015 Ki 4.3 nM
Cc1c(C2=NN3CC[C@H](O)[C@H]3[C@@H]2OC(C)C)ccc(C#N)c1Cl CHEMBL3326456 EC50 4.5 nM
C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@@H](c3ccc(N(C)CCCOC4CC[C@@]5(C)[C@@H](C4)C[C@@H](O)[C@@H]4[C@@H]5C[C@H](O)[C@]5(C)[C@@H]([C@H](C)CCC(=O)O)CC[C@@H]45)cc3)C[C@@]21C CHEMBL415621 Ki 4.6 nM
C[C@@H]1CN(c2ccc(C#N)c(C(F)(F)F)c2)[C@@H](C)CN1C(=O)Nc1ccc(C(F)(F)F)nc1 CHEMBL197595 Ki 4.6 nM
CC(=O)O[C@]1(C(C)=O)CCC2C3C=C(Cl)C4=CC(=O)[C@@H]5CC5[C@]4(C)C3CC[C@@]21C CHEMBL361245 IC50 4.7 nM
C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@@H](c3ccc(N(C)CCOCCO[C@@H]4CC[C@@]5(C)[C@@H](C4)C[C@@H](O)[C@@H]4[C@@H]5C[C@H](O)[C@]5(C)[C@@H]([C@H](C)CCC(=O)O)CC[C@@H]45)cc3)C[C@@]21C CHEMBL2096804 Ki 4.8 nM
CCCCCCCCCCCCCC(=O)O[C@H]1CC[C@H]2[C@H]3[C@H]([C@@H](C)C[C@]12C)[C@H]1CCC(=O)C=C1C[C@H]3C CHEMBL5192080 EC50 4.8 nM
Cc1c(N[C@@H]2CCCC[C@@]2(C)O)ccc(C#N)c1Cl CHEMBL3765823 EC50 4.88 nM
Cc1c(O)ccc(-c2ccc(C#N)n2C)c1C CHEMBL4072730 IC50 4.9 nM
C[C@@H]1c2cc3c(C(F)(F)F)cc(O)nc3cc2N[C@@H]1C CHEMBL162569 EC50 5.0 nM
Oc1cc(C(F)(F)F)c2cc3c(cc2n1)N[C@@H]1CCCC[C@H]31 CHEMBL350932 EC50 5.0 nM
O=c1cc(C(F)(F)F)c2cc3c(cc2o1)NCCC3C(F)(F)C(F)(F)F CHEMBL266928 IC50 5.0 nM
CC[C@@H]1CNc2cc3oc(=O)cc(C(F)(F)F)c3cc2[C@H]1CC CHEMBL2112310 EC50 5.0 nM
CC[C@H]1CNc2cc3oc(=O)cc(C(F)(F)F)c3cc2[C@@H]1CC CHEMBL2052002 EC50 5.0 nM
CCCC1CCNc2cc3oc(=O)cc(C(F)(F)F)c3cc21 CHEMBL6855 EC50 5.0 nM
CC1(C)CCc2cc3c(C(F)(F)F)ccnc3cc2N1 CHEMBL338922 Ki 5.0 nM
O=C1[C@@H]2C3C=CC(C3)[C@@H]2C(=O)N1c1ccc([N+](=O)[O-])c(C(F)(F)F)c1 CHEMBL368906 Ki 5.0 nM
O=C1[C@@H]2[C@@H]3CC[C@@H](C3)[C@@H]2C(=O)N1c1ccc([N+](=O)[O-])c(C(F)(F)F)c1 CHEMBL188297 Ki 5.0 nM
Cn1cc(N(Cc2ccccc2)c2ccc([N+](=O)[O-])cc2)cc1C(=O)N1CCCC1 CHEMBL518945 Ki 5.0 nM
CN1C(=O)C=C[C@]2(C)[C@H]3CC[C@]4(C)[C@@H](O)CC[C@H]4[C@@H]3CC[C@@H]12 CHEMBL559246 EC50 5.0 nM
CNc1ncc(/C=C2\C[C@H]3[C@@H]4CC[C@H]5N(C)C(=O)C=C[C@]5(C)[C@H]4CC[C@]3(C)[C@H]2O)cn1 CHEMBL563597 EC50 5.0 nM
CN1C(=O)N(c2ccc(C#N)c(C(F)(F)F)c2)C(=O)C1(CO)c1cccc(Cl)c1 CHEMBL2178660 Activity 5.0 nM
CNC(=O)[C@@]12[C@@H](CN(c3ccc(C#N)c(C(F)(F)F)c3)S1(=O)=O)[C@H]1C[C@H](F)[C@@H]2C1 CHEMBL3902310 Ki 5.0 nM
CCOC(=O)c1c(-c2ccc([N+](=O)[O-])cc2)c(C)n(Cc2ccccc2)c1C CHEMBL1934430 IC50 5.2 nM
Cc1c(N[C@@H]2COC[C@@]2(C)O)ccc(C#N)c1Cl CHEMBL3764446 Ki 5.21 nM
Cn1c(C#N)ccc1-c1c(F)cc(O)cc1C#N CHEMBL4104046 EC50 5.3 nM
CCc1cc(=O)[nH]c2ccc(N(CC(F)(F)F)CC(F)(F)F)cc12 CHEMBL238123 Ki 5.4 nM
C[C@@H]1COc2c(ccc3[nH]c(=O)cc(C(F)(F)F)c23)N1CC(F)(F)F CHEMBL395596 EC50 5.4 nM
N#Cc1ccc(N2C(=O)C3C(O)CCN3C2=O)c2ccccc12 CHEMBL218914 Ki 5.5 nM
CC(C)C[C@H]1[C@@H](O)CC(=O)N1c1ccc(C#N)c(Cl)c1 CHEMBL4093265 IC50 5.5 nM
COC(=O)c1ccc(C2C(=S)N(c3ccc(C#N)c(C(F)(F)F)c3)C(=O)[C@]23CCOC3)cc1F CHEMBL5272485 Ki 5.6 nM
Cc1c(C(O)(c2ccc(Cl)s2)C(F)(F)F)ccc(C#N)c1C(F)(F)F CHEMBL3818882 pEC50 5.623 nM
CCOC(=O)N1C[C@@]2(C)O[C@@](C)(C1)[C@@H]1C(=O)N(c3ccc(C#N)c(C(F)(F)F)c3)C(=O)[C@@H]12 CHEMBL1209973 Ki 5.7 nM
Cc1c(C(O)(c2cscn2)C(F)(F)F)ccc(C#N)c1C(F)(F)F CHEMBL3819595 pEC50 5.888 nM
CC(C)[C@@H]1COc2cc3[nH]c(=O)cc(C(F)(F)F)c3cc2N1CC(F)(F)F CHEMBL226559 EC50 5.9 nM
CCC(C)N(CC(F)(F)F)c1ccc2[nH]c(=O)cc(C(F)(F)F)c2c1 CHEMBL393865 EC50 5.9 nM
O=c1cc(C(F)(F)F)c2cc3c(cc2[nH]1)OCC(C(F)(F)F)N3CC(F)(F)F CHEMBL256330 EC50 5.9 nM
C/C(=C1/c2ccccc2COc2ccccc21)c1cccc(NS(C)(=O)=O)c1 CHEMBL3120319 Ki 5.98 nM
CC1(C)NC(=O)N(c2ccc(C#N)c(C(F)(F)F)c2)C1=O CHEMBL146858 IC50 6.0 nM
C[C@@H]1C[C@H](C)c2cc3c(C(F)(F)F)cc(O)nc3cc2N1 CHEMBL268326 Ki 6.0 nM
O=C1[C@@H]2C3C=CC(C3)[C@@H]2C(=O)N1c1cc(Cl)cc(Cl)c1 CHEMBL178886 Ki 6.0 nM
O=C1[C@@H]2C3C=CC(C3)[C@@H]2C(=O)N1c1ccc(Cl)c(Cl)c1 CHEMBL182593 Ki 6.0 nM
CCC1COc2cc3[nH]c(=O)cc(C(F)(F)F)c3cc2N1CC(F)(F)F CHEMBL388997 EC50 6.0 nM
Cn1cc(N(Cc2ccccc2)c2ccc(C#N)cc2)cc1C(=O)N1CCCC1 CHEMBL480955 Ki 6.0 nM
CCCC(C)N1CC(C)(C)C(Oc2ccc(C#N)c(C(F)(F)F)c2)C1=O CHEMBL1830778 IC50 6.0 nM
CN1CCN(OC(=O)N[C@@H]2C[C@]3(C)O[C@]2(C)[C@@H]2C(=O)N(c4ccc(C#N)c(C(F)(F)F)c4)C(=O)[C@@H]23)CC1 CHEMBL3623122 IC50 6.0 nM
C[C@]12CCC3C4CCC(=O)C=C4CCC3C1C1CC1[C@@]21CCC(=O)O1 CHEMBL3658376 IC50 6.0 nM
C[C@H]1[C@@H](O)[C@H](Cc2ccccc2)C(=O)N1c1ccc(C#N)c(Cl)c1 CHEMBL4101935 IC50 6.0 nM
C[C@@](O)(COc1ccc(F)cc1)C(=O)Nc1ccc([N+](=O)[O-])c(C(F)(F)F)c1 CHEMBL125663 Ki 6.0 nM
C[C@](O)(Cn1ccc2cc(F)ccc21)C(=O)Nc1ccc(C#N)c(C(F)(F)F)c1 CHEMBL4444904 IC50 6.05 nM
C[C@](O)(Cn1ccc2cc(F)ccc21)C(=O)Nc1cnc(C#N)c(C(F)(F)F)c1 CHEMBL5409022 IC50 6.08 nM
CC(=O)C[C@]1(C(C)=O)CC[C@H]2C3C[C@H](C)C4=CC(=O)CC[C@]4(C)[C@H]3CC[C@@]21C CHEMBL292284 IC50 6.1 nM
COc1c(C#N)ccc(N2C(=O)[C@@H]3[C@H](O)CCN3C2=O)c1Cl CHEMBL394593 Ki 6.1 nM
COC[C@]1(OC)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@@H](c3ccc(/C=N/O)cc3)C[C@@]21C CHEMBL267431 IC50 6.1 nM
C[C@](O)(COc1ccc(F)cc1)C(=O)Nc1ccc([N+](=O)[O-])c(C(F)(F)F)c1 CHEMBL124718 Ki 6.1 nM
C[C@]12CN(c3ncccn3)C[C@](C)(O1)[C@@H]1C(=O)N(c3ccc(C#N)c(C(F)(F)F)c3)C(=O)[C@@H]12 CHEMBL1210214 Ki 6.1 nM
C[C@](O)(COc1ccccc1Cl)C(=O)N1CCc2c(C#N)cccc21 CHEMBL3238279 EC50 6.1 nM
C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@@H](c3ccc(N(C)CCNC(=O)OC4CC[C@@]5(C)[C@@H](C4)C[C@@H](O)[C@@H]4[C@@H]5C[C@H](O)[C@]5(C)[C@@H]([C@H](C)CCC(=O)O)CC[C@@H]45)cc3)C[C@@]21C CHEMBL266935 Ki 6.2 nM
N#Cc1ccc(N2C(=O)[C@@H]3[C@H](O)CCN3C2=O)c2ncccc12 CHEMBL397274 EC50 6.2 nM
Cc1nn(-c2ccc(C#N)c(Cl)c2)c(C)c1Oc1ccc(F)cc1 CHEMBL1957615 IC50 6.3 nM
Cn1c(C#N)ccc1-c1ccc(O)cc1 CHEMBL4087256 IC50 6.3 nM
O=c1cc(C(F)(F)F)c2cc(N(CCO)CC(F)(F)F)ccc2[nH]1 CHEMBL237682 Ki 6.6 nM
O=c1cc(C(F)(F)F)c2cc3c(cc2[nH]1)OC[C@H](CO)N3CC(F)(F)F CHEMBL436644 EC50 6.6 nM
CCCOC(=O)N1C[C@@]2(C)O[C@@](C)(C1)[C@@H]1C(=O)N(c3ccc(C#N)c(C(F)(F)F)c3)C(=O)[C@@H]12 CHEMBL1210033 Ki 6.6 nM
CCCCN(CC(F)(F)F)c1ccc2[nH]c(=O)cc(C(F)(F)F)c2c1 CHEMBL393864 EC50 6.8 nM
COC(=O)c1ccc(OC[C@](C)(O)C(=O)N2CCc3c(C#N)cccc32)cc1 CHEMBL3238283 EC50 6.8 nM
Cn1c(C#N)ccc1-c1ccc(O)cc1C#N CHEMBL4066319 IC50 6.8 nM
CC[C@H]1c2cc3c(C(F)(F)F)cc(O)nc3cc2NC[C@H]1C CHEMBL2113261 EC50 7.0 nM
CCC1c2cc3c(C(F)(F)F)cc(O)nc3cc2NC[C@@H]1C CHEMBL418198 EC50 7.0 nM
C[C@@H]1Cc2cc3c(C(F)(F)F)cc(O)nc3cc2N1 CHEMBL351465 IC50 7.0 nM
CCC1CC(CC)c2cc3c(C(F)(F)F)cc(=O)oc3cc2N1 CHEMBL6721 IC50 7.0 nM
C[C@@H]1CCc2cc3c(C(F)(F)F)cc(O)nc3cc2N1 CHEMBL267141 Ki 7.0 nM
O=C1[C@@H]2C3C=CC(C3)[C@@H]2C(=O)N1c1cccc(C(F)(F)F)c1 CHEMBL178469 Ki 7.0 nM
O=c1cc(O)c2cc(N(CC(F)(F)F)CC(F)(F)F)ccc2[nH]1 CHEMBL235126 IC50 7.0 nM
C=CC(O)(c1nc2cc(Cl)c(Cl)cc2[nH]1)C(F)(F)F CHEMBL246007 IC50 7.0 nM
CCC(C)N(C)c1cc(C(F)(F)F)c(C#N)cn1 CHEMBL249070 IC50 7.0 nM
CC12CCC(C)(O1)[C@H]1C(=O)N(c3ccc(C#N)c(C(F)(F)F)c3)C(=O)[C@H]12 CHEMBL403669 IC50 7.0 nM
COC(=O)c1ccc(N(Cc2ccccc2)c2cc(C(=O)N3CCCC3)n(C)c2)cc1 CHEMBL480959 Ki 7.0 nM
CCN1C(=O)N(c2ccc(C#N)c(C(F)(F)F)c2)C(=O)C1(CO)c1ccccc1 CHEMBL2178093 Activity 7.0 nM
CC1(C)CCCN1c1ccc(C#N)c2ccccc12 CHEMBL3402223 IC50 7.0 nM
Cc1c(N[C@@H](c2ccc(-c3ccc(C#N)cc3)o2)[C@H](C)O)ccc(C#N)c1Cl CHEMBL5189325 Ki 7.0 nM
CO[C@H]1CCN2N=C(c3ccc(C#N)c(Cl)c3C)[C@@H](OC)[C@H]12 CHEMBL3326459 EC50 7.1 nM
CCc1cc(-c2ccc(C#N)n2C)ccc1O CHEMBL4103641 IC50 7.1 nM
CC12C[C@H](O)C(C)(O1)[C@@H]1C(=O)N(c3ccc(C#N)c(I)c3)C(=O)[C@@H]12 CHEMBL255331 Ki 7.18 nM
C[C@](O)(COc1ccc(-c2cocn2)cc1)C(=O)N1CCc2c(C#N)cccc21 CHEMBL3238284 EC50 7.2 nM
C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@@H](c3ccc(N(C)CCCC(=O)N(C)C4CC[C@@]5(C)[C@@H](C4)C[C@@H](O)[C@@H]4[C@@H]5C[C@H](O)[C@]5(C)[C@@H]([C@H](C)CCC(=O)O)CC[C@@H]45)cc3)C[C@@]21C CHEMBL408376 Ki 7.4 nM
C[C@]12CN(c3cccc(C(N)=O)c3)C[C@](C)(O1)[C@@H]1C(=O)N(c3ccc(C#N)c(C(F)(F)F)c3)C(=O)[C@@H]12 CHEMBL1210783 IC50 7.4 nM
C[C@]12CN(c3cccc(S(C)(=O)=O)c3)C[C@](C)(O1)[C@@H]1C(=O)N(c3ccc(C#N)c(C(F)(F)F)c3)C(=O)[C@@H]12 CHEMBL1210151 IC50 7.4 nM
CC(=O)O[C@]1(C(C)=O)CC[C@H]2[C@@H]3C=C(Cl)C4=CC(=O)CC[C@]4(C)[C@H]3CC[C@@]21C CHEMBL110691 AC50 7.4 nM
COC(=O)[C@H]1CCN(c2ccc(C#N)c3ccccc23)[C@H]1C CHEMBL3402233 IC50 7.5 nM
C[C@@H]1CC[C@H]([C@H](O)C(F)(F)F)N1c1ccc2[nH]c(=O)cc(C(F)(F)F)c2c1 CHEMBL2113293 Ki 7.6 nM
COc1cc(C#N)ccc1OC[C@](C)(O)C(=O)N1CCc2c(C#N)cccc21 CHEMBL3238293 EC50 7.6 nM
CC1CN(CC(F)(F)F)c2cc3c(C(F)(F)F)cc(=O)[nH]c3cc2O1 CHEMBL227408 EC50 7.8 nM
CC(C)(C)N1CCOc2cc3[nH]c(=O)cc(C(F)(F)F)c3cc21 CHEMBL375907 EC50 7.8 nM
N#Cc1ccc(N2C(=O)[C@@H]3[C@H](O)CCN3C2=O)cc1C(F)(F)F CHEMBL388421 Ki 7.8 nM
C[C@H]1[C@@H](O)CC(=O)N1c1ccc(C#N)c(Cl)c1 CHEMBL4071751 IC50 7.8 nM
C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@@H]4[C@H]3C(=C)C[C@@]21CC CHEMBL1531 AC50 7.8 nM
C=C[C@]12CCC(=O)C=C1CCC1C2CC[C@@]2(C)C1CC[C@@H]2O CHEMBL203748 IC50 7.9 nM
COc1c(N2C(=O)[C@@H]3[C@H](O)CCN3C2=O)ccc(C#N)c1C(F)(F)F CHEMBL231327 Ki 7.9 nM
C=C[C@]12CCC(=O)C=C1CC[C@H]1[C@@H]3CC[C@H](O)[C@@]3(C)CC[C@@H]12 CHEMBL246140 IC50 7.9 nM
CC(C)C(O)(c1ccc(C#N)c(C(F)(F)F)c1)C(F)(F)F CHEMBL3818826 pEC50 7.943 nM
CC1c2cc3c(C(F)(F)F)cc(O)nc3cc2NC[C@H]1C CHEMBL282204 Ki 8.0 nM
Oc1cc(C(F)(F)F)c2cc3c(cc2n1)NC[C@@H]1CCC[C@H]31 CHEMBL27812 Ki 8.0 nM
CCC1CC(C)c2cc3c(C(F)(F)F)cc(=O)oc3cc2N1 CHEMBL269305 EC50 8.0 nM
CC[C@@H]1CCc2cc3c(C(F)(F)F)cc(O)nc3cc2N1 CHEMBL7177 Ki 8.0 nM
O=c1cc(C(F)(F)F)c2c3c(ccc2[nH]1)-c1ccccc1CO3 CHEMBL450334 Ki 8.0 nM
CN1C(=O)C=C[C@]2(C)[C@H]3CC[C@]4(C)[C@@H](O)/C(=C/c5cc(F)cc(F)c5)C[C@H]4[C@@H]3CC[C@@H]12 CHEMBL556431 EC50 8.0 nM
Cc1ncc(/C=C2\C[C@H]3[C@@H]4CC[C@H]5N(C)C(=O)C=C[C@]5(C)[C@H]4CC[C@]3(C)[C@H]2O)cn1 CHEMBL549375 EC50 8.0 nM
CN1C(=O)N(c2ccc(C#N)c(C(F)(F)F)c2)C(=O)C1(CO)c1ccc(Cl)cc1 CHEMBL2178661 Activity 8.0 nM
C[C@@H]1N(c2ccc(C#N)c(Cl)c2)CC[C@@]1(O)c1ccc(F)cc1 CHEMBL2337509 IC50 8.0 nM
C[C@]12O[C@@](C)(C[C@@H]1O)[C@H]1C(=O)N(c3ccc(C#N)c(I)c3)C(=O)[C@H]12 CHEMBL3623114 Ki 8.0 nM
C[C@@]12[C@@H](CN(c3ccc(C#N)c(C(F)(F)F)c3)S1(=O)=O)[C@H]1C[C@H](F)[C@@H]2C1 CHEMBL3949176 Ki 8.0 nM
C[C@@]12[C@@H]3CC[C@@H](C3=O)[C@@H]1CN(c1ccc(C#N)c(C(F)(F)F)c1)S2(=O)=O CHEMBL3935242 Ki 8.0 nM
CNC(=O)[C@]12C(=O)N(c3ccc(C#N)c(C(F)(F)F)c3)C(=O)[C@H]1[C@H]1C[C@H](F)[C@@H]2C1 CHEMBL5194764 Ki 8.0 nM
C[C@]12CC[C@H]3[C@@H](C[C@H](F)C4=CC(=O)CC[C@@]43C)[C@@H]1CC[C@@H]2O CHEMBL1565119 EC50 8.0 nM
C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@@H](c3ccc(N(C)CCOC4CC[C@@]5(C)[C@@H](C4)C[C@@H](O)[C@@H]4[C@@H]5C[C@H](O)[C@]5(C)[C@@H]([C@H](C)CCC(=O)O)CC[C@@H]45)cc3)C[C@@]21C CHEMBL427568 Ki 8.1 nM
COc1c(N2C(=O)[C@@H]3[C@H](O)CCN3C2=O)ccc(C#N)c1C CHEMBL395502 Ki 8.1 nM
Cn1c(C#N)ccc1-c1ccc(O)c2c1CCC2 CHEMBL4061510 IC50 8.1 nM
Cc1c(N2C(=O)[C@]3(C)[C@H](O)CCN3S2(=O)=O)ccc(C#N)c1Cl CHEMBL391768 Ki 8.2 nM
Cc1nn(-c2ccc(C#N)c(Cl)c2)c(C)c1C(O)c1ccc(F)cc1 CHEMBL1957618 IC50 8.3 nM
CN1CCC(Oc2ccc(N3C(=S)N(c4cnc(C#N)c(C(F)(F)F)c4)C(=O)C34CCC4)cc2)CC1 CHEMBL4865865 Ki 8.4 nM
CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C CHEMBL103 Ki 8.5 nM
Cc1cc(C#N)ccc1N1C(=O)[C@@H]2[C@H](O)CCN2C1=O CHEMBL389606 Ki 8.5 nM
CNC(=O)c1ccc([C@]2(O)CCN(c3ccc(C#N)c(Cl)c3)[C@H]2C)cc1 CHEMBL2337511 IC50 8.6 nM
COc1ccc(OC[C@](C)(O)C(=O)N2CCc3c(C#N)cccc32)cc1 CHEMBL3238282 EC50 8.6 nM
C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@@H](c3ccc(N(C)CCOC4CC[C@@]5(C)[C@@H](C4)C[C@@H](O)[C@@H]4[C@@H]5C[C@H](O)[C@]5(C)[C@@H]([C@H](C)CCC(=O)NCCS(=O)(=O)O)CC[C@@H]45)cc3)C[C@@]21C CHEMBL407672 Ki 8.9 nM
C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@@H](c3ccc(N(C)C(C)=O)cc3)C[C@@]21C CHEMBL364368 Ki 8.9 nM
CC1(C)NC(=O)N(c2ccc([N+](=O)[O-])c(C(F)(F)F)c2)C1=O CHEMBL1274 IC50 9.0 nM
CCC1CCNc2cc3c(cc21)c(C(F)(F)F)cc(=O)n3C CHEMBL27297 Ki 9.0 nM
CC1CCNc2cc3nc(O)cc(C(F)(F)F)c3cc21 CHEMBL283449 Ki 9.0 nM
C[C@H]1Nc2cc3c(cc2C1(C)C)c(C(F)(F)F)cc(=O)n3C CHEMBL351519 Ki 9.0 nM
Cn1c(=O)cc(C(F)(F)F)c2cc3c(cc21)N[C@@H]1CCCC[C@]31C CHEMBL422196 Ki 9.0 nM
C[C@@H]1Cc2cc3c(C(F)(F)F)cc(=O)n(C)c3cc2N1 CHEMBL163366 Ki 9.0 nM
Oc1cc(C(F)(F)F)c2cc3c(cc2n1)NC1(CCCCC1)CC3 CHEMBL345854 Ki 9.0 nM
CC[C@H]1Cc2cc3c(C(F)(F)F)cc(O)nc3cc2N[C@@H]1C CHEMBL7053 EC50 9.0 nM
CC[C@@H]1C[C@H](CC)c2cc3c(C(F)(F)F)cc(O)nc3cc2N1 CHEMBL7383 Ki 9.0 nM
CC1(C)CCc2cc3c(C(F)(F)F)cc(C#N)nc3cc2N1 CHEMBL335316 IC50 9.0 nM
O=C1[C@@H]2C3C=CC(CCC3)[C@@H]2C(=O)N1c1ccc([N+](=O)[O-])c2ccccc12 CHEMBL369542 Ki 9.0 nM
O=C1[C@@H]2C3C=CC([C@H]4C[C@@H]34)[C@@H]2C(=O)N1c1cccc(C(F)(F)F)c1 CHEMBL182993 Ki 9.0 nM
CCCc1cc2c(C(F)(F)F)cc(=O)[nH]c2cc1N CHEMBL3706898 Ki 9.0 nM
CN(CC(F)(F)F)c1ccc2[nH]c(=O)cc(C(F)(F)F)c2c1 CHEMBL237259 Ki 9.0 nM
Cn1cc(N(Cc2ccccc2)c2ccc([N+](=O)[O-])cc2)cc1C(=O)N1CCc2ccccc21 CHEMBL503676 Ki 9.0 nM
Cc1c(C#N)c(-c2ccc(C#N)cc2)c(C)n1Cc1ccc(Cl)nc1 CHEMBL1934444 IC50 9.0 nM
C[C@@H]1N(c2ccc(C#N)c(Cl)c2)CC[C@@]1(O)c1ccc(C(N)=O)cc1 CHEMBL2337510 IC50 9.0 nM
N#Cc1cccc2c(O[C@H]3CC[C@H](NC(=O)c4cccc(F)c4)CC3)ccnc12 CHEMBL3920715 IC50 9.0 nM
CC[C@H]1[C@@H](O)CC(=O)N1c1ccc(C#N)c(Cl)c1C CHEMBL4087902 IC50 9.0 nM
CC1(C)CCc2cc3c(cc2N1)NC(C#N)C=C3C(F)(F)F CHEMBL4447539 IC50 9.0 nM
COC(=O)C(c1ccc(F)cc1Cl)n1ccc2c(C#N)cccc21 CHEMBL4746794 Activity 9.0 nM
CC(=O)O[C@]1(C(C)=O)CC[C@H]2[C@@H]3C=C(Cl)C4=CC(=O)[C@@H]5C[C@@H]5[C@]4(C)[C@H]3CC[C@@]21C CHEMBL139835 AC50 9.0 nM
CC[C@H]1[C@@H](O)CC(=O)N1c1ccc(C#N)c(OC)c1 CHEMBL4059588 IC50 9.2 nM
C[C@@H]1CC2=CC(=O)CC[C@@H]2[C@H]2CC[C@]3(C)[C@@H](O)CC[C@H]3[C@@H]21 CHEMBL5197302 EC50 9.2 nM
C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@@H]4[C@H]3CC[C@@]21CC CHEMBL1389 AC50 9.2 nM
CO[C@@H]1C(c2ccc(C#N)c(Cl)c2C)=NN2C[C@H](O)C[C@@H]12 CHEMBL3326462 EC50 9.7 nM
CC/C(=C1/c2ccccc2COc2ccccc21)c1cccc(NS(C)(=O)=O)c1 CHEMBL3120318 Ki 9.74 nM
N#Cc1ccc(-c2ccccc2Cl)cc1C(F)(F)F CHEMBL238365 IC50 9.8 nM