Cc1cn2c(-c3cn[nH]c3)cnc2c(Nc2cc(C(NC(C)(C)C)c3ccccn3)ns2)n1 CHEMBL4225923 Kd 0.01 nM
COc1ccc(C(=O)Nc2cccc(CNc3ncnc4c(C(N)=O)cccc34)c2)cn1 CHEMBL3680444 IC50 0.042 nM
NC(=O)c1cccc2c(NCc3ccc(NC(=O)c4cc(C(F)(F)F)n[nH]4)cc3)ncnc12 CHEMBL3680508 IC50 0.045 nM
CCN(CC)c1ccc(C(=O)Nc2cccc(C(C)Nc3ncnc4c(C(N)=O)cccc34)c2)cc1 CHEMBL3680447 IC50 0.046 nM
N#Cc1ccnc(Nc2cccc(CNc3ncnc4c(C(N)=O)cccc34)c2)c1 CHEMBL3680552 IC50 0.06 nM
Cc1cccc(C(=O)Nc2cccc(CNc3ncnc4c(C(N)=O)cccc34)c2)c1 CHEMBL3685243 IC50 0.061 nM
NC(=O)c1cccc2c(NCc3cccc(NC(=O)c4cc(C5CC5)n[nH]4)c3)ncnc12 CHEMBL3685277 IC50 0.089 nM
Cc1cn2c(-c3cn[nH]c3)cnc2c(Nc2cc(Cc3ccccn3)ns2)n1 CHEMBL4227082 Kd 0.1 nM
NC(=O)c1cccc2c(NCc3cccc(NC(O)c4cc(C(F)(F)F)ccc4F)c3)ncnc12 CHEMBL3675525 IC50 0.17 nM
NC(=O)c1cccc2c(NCc3cccc(NC(=O)c4ccc(Cl)cc4)c3)ncnc12 CHEMBL3685262 IC50 0.18 nM
N#CCc1ccnc(Nc2cccc(CNc3ncnc4c(C(N)=O)cccc34)c2)c1 CHEMBL3680596 IC50 0.18 nM
NC(=O)c1cccc2c(NCc3cccc(NC(=O)c4ccc5c(c4)OC(F)(F)O5)c3)ncnc12 CHEMBL3639841 IC50 0.2 nM
NC(=O)c1cccc2c(NCc3cccc(NC(=O)c4ccc(C(F)(F)F)cc4F)c3)ncnc12 CHEMBL3685245 IC50 0.21 nM
COc1cc(F)c(C(=O)Nc2cccc(CNc3ncnc4c(C(N)=O)cccc34)c2)c(F)c1 CHEMBL3685306 IC50 0.22 nM
NC(=O)c1cc(O)cc2c(NCc3ccc(C(F)(F)F)cc3)ncnc12 CHEMBL3670499 IC50 0.24 nM
NC(=O)c1cccc2c(NCc3cccc(NC(=O)c4ccc(F)cc4F)c3)ncnc12 CHEMBL3675441 IC50 0.25 nM
CNc1ccc(C(=O)Nc2cccc(CNc3ncnc4c(C(N)=O)cccc34)c2)cn1 CHEMBL3680500 IC50 0.26 nM
CC(C)c1cc(C(=O)Nc2cccc(C(C)Nc3ncnc4c(C(N)=O)cccc34)c2)[nH]n1 CHEMBL3680420 IC50 0.27 nM
CC1(C)CC(NC(=O)c2ccc(Nc3ncc(Cl)c(Nc4ccccc4Cl)n3)cc2)CC(C)(C)N1[O] CHEMBL4455202 IC50 0.29 nM
CCN(CCO)CCCOc1ccc2c(Nc3cc(CC(=O)Nc4cccc(F)c4)[nH]n3)ncnc2c1 CHEMBL215152 IC50 0.3 nM
NC(=O)c1cccc2c(NCc3cccc(NC(=O)c4[nH]nc5c4CCCC5)c3)ncnc12 CHEMBL3680554 IC50 0.3 nM
NC(=O)c1cccc2c(NCc3cccc(NC(=O)c4ccc(Cl)c(Cl)c4)c3)ncnc12 CHEMBL3680403 IC50 0.3 nM
COc1ccc(C(=O)Nc2cccc(CNc3ncnc4c(C(N)=O)cccc34)c2)cc1OC CHEMBL3685257 IC50 0.31 nM
Cn1cc(-c2ccc3c(Nc4cccc(NC(=O)Nc5cccc(F)c5)c4)ncnc3c2)cn1 CHEMBL4799738 IC50 0.316 nM
Cc1ccc(C(=O)Nc2cccc(C(C)Nc3ncnc4c(C(N)=O)cccc34)c2)cn1 CHEMBL3675501 IC50 0.32 nM
CC(C)c1cc(C(=O)Nc2cccc(CNc3ncnc4c(C(N)=O)cccc34)c2)[nH]n1 CHEMBL3685237 IC50 0.33 nM
Cn1cc(-c2ccc3c(Nc4ccc(NC(=O)Nc5cccc(F)c5)cc4)ncnc3c2)cn1 CHEMBL4784002 IC50 0.336 nM
CC1(C)CC(NC(=O)c2ccc(Nc3ncc([N+](=O)[O-])c(Nc4ccc(Cl)cc4)n3)cc2)CC(C)(C)N1[O] CHEMBL4443125 IC50 0.34 nM
CN(C)CCC(Nc1ncnc2c(C(N)=O)cccc12)c1cccc(NC(=O)c2ccc(Br)cc2)c1 CHEMBL3675459 IC50 0.35 nM
NC(=O)c1cccc2c(NCc3cccc(NC(=O)c4ccc(Cl)cc4Cl)c3)ncnc12 CHEMBL3675446 IC50 0.35 nM
COc1ccc(C(=O)Nc2cccc(CNc3ncnc4c(C(N)=O)cccc34)c2)cc1 CHEMBL3670467 IC50 0.35 nM
CCN(CCCOc1ccc2c(Nc3cc(CC(=O)Nc4cccc(F)c4)[nH]n3)ncnc2c1)CCOP(=O)(O)O CHEMBL415049 Ki 0.37 nM
CCN(CCCOc1ccc2c(Nc3cc(CC(=O)Nc4cccc(F)c4)[nH]n3)ncnc2c1)CCP(=O)(O)O CHEMBL4633715 IC50 0.37 nM
CCn1cc(-c2ccnc3[nH]c(-c4cccc(CN(C)C)c4)cc23)c(-c2ccc(NC(=O)N(C)C)cc2)n1 CHEMBL1090479 Ki 0.38 nM
NC(=O)c1cccc2c(NCc3cccc(NC(=O)c4ccc(C(F)(F)F)nc4)c3)ncnc12 CHEMBL3685250 IC50 0.38 nM
NC(=O)c1cccc2c(NCc3cccc(NC(=O)c4cccc(Cl)c4)c3)ncnc12 CHEMBL3685252 IC50 0.38 nM
COCC[C@@H](Nc1ncnc2c(C(N)=O)cccc12)c1cccc(NC(=O)c2ccc(OC)cc2)c1 CHEMBL3680550 IC50 0.38 nM
Cc1ccnc(Nc2cccc(CNc3ncnc4c(C(N)=O)cccc34)c2)c1 CHEMBL3680572 IC50 0.39 nM
O=C(Nc1ccc(Nc2ccnc3[nH]c(=O)c4ccccc4c23)cc1)c1ccc(F)cc1C(F)(F)F CHEMBL2380834 IC50 0.4 nM
COc1ccc(C(=O)NC(=O)Nc2ccc3c(c2)NC(=O)/C3=C\c2[nH]c(C)c(C(=O)NCCN3CCCC3)c2C)c(F)c1 CHEMBL3329684 IC50 0.4 nM
CC(Nc1ncnc2c(C(N)=O)cccc12)c1cccc(NC(=O)c2ccc(F)c(O)c2)c1 CHEMBL3675444 IC50 0.4 nM
CC(Nc1ncnc2c(C(N)=O)cccc12)c1cccc(NC(=O)C2=CCC(Cl)N=C2)c1 CHEMBL3675493 IC50 0.4 nM
COc1ccc(C(=O)Nc2cccc([C@@H](C)Nc3ncnc4c(C(N)=O)cccc34)c2)cc1F CHEMBL3680460 IC50 0.41 nM
CC(Nc1ncnc2c(C(N)=O)cccc12)c1cccc(NC(=O)c2ccc3c(c2)OCO3)c1 CHEMBL3675438 IC50 0.43 nM
NC(=O)c1cccc2c(NCc3cccc(NC(=O)c4ccc5c(c4)CCO5)c3)ncnc12 CHEMBL3680417 IC50 0.46 nM
NC(=O)c1cccc2c(NCc3cccc(NC(=O)c4ccc(Cl)nc4)c3)ncnc12 CHEMBL3670485 IC50 0.46 nM
NC(=O)c1cccc2c(NCc3cccc(NC(=O)C4=CC(F)C(Cl)C=C4)c3)ncnc12 CHEMBL3675510 IC50 0.47 nM
O=C(Nc1ccc(Nc2ccnc3[nH]c(=O)c4ccccc4c23)cc1)c1cccc(F)c1F CHEMBL2380829 IC50 0.5 nM
CC(=O)Nc1ccc(C(=O)Nc2cccc(CNc3ncnc4c(C(N)=O)cccc34)c2)cc1 CHEMBL3685249 IC50 0.5 nM
COc1ccc(C(=O)Nc2cccc(CNc3ccnc4c(C(N)=O)cccc34)c2)cc1F CHEMBL3680522 IC50 0.5 nM
CCC(Nc1ncnc2c(C(N)=O)cccc12)c1cccc(NC(=O)C2CC(F)(F)C2)c1 CHEMBL3680588 IC50 0.5 nM
Cc1nc(-c2cccc(C(=O)Nc3cccc(CNc4ncnc5c(C(N)=O)cccc45)c3)c2)no1 CHEMBL3680587 IC50 0.5 nM
Cc1cnc(Nc2cc(Cc3ccccc3)nc(N[C@H]3CC[C@H](O)CC3)n2)s1 CHEMBL2441267 pKi 0.5012 nM
NC(=O)c1cccc2c(NCc3cccc(NC(=O)c4cc(C(F)(F)F)n[nH]4)c3)ncnc12 CHEMBL3680455 IC50 0.51 nM
CN(C)c1ccc(C(=O)Nc2cccc(CNc3ncnc4c(C(N)=O)cccc34)c2)cc1 CHEMBL3670470 IC50 0.52 nM
NC(=O)c1cccc2c(NCc3cccc(NC(=O)c4ccc(Cl)c(C(F)(F)F)c4)c3)ncnc12 CHEMBL3685272 IC50 0.52 nM
CCC(Nc1ncnc2c(C(N)=O)cccc12)c1cccc(NC(=O)C2CC2(F)F)c1 CHEMBL3680599 IC50 0.54 nM
COc1ccc(C(=O)Nc2cccc(C(C)Nc3ncnc4c(C(N)=O)cccc34)c2)cc1F CHEMBL3680446 IC50 0.57 nM
NC(=O)c1cccc2c(NCC3C=CC=C(NC=O)C3)ncnc12 CHEMBL3680467 IC50 0.58 nM
CCn1nc(C(F)(F)F)cc1C(=O)Nc1cccc(C(C)Nc2ncnc3c(C(N)=O)cccc23)c1 CHEMBL3680421 IC50 0.58 nM
NC(=O)c1cccc2c(NCc3ccc(F)cc3F)ncnc12 CHEMBL3639742 IC50 0.59 nM
O=C(Nc1ccc(Nc2ccnc3[nH]c(=O)c4ccccc4c23)cc1)c1c(F)cccc1F CHEMBL2380831 IC50 0.6 nM
COc1ccc(C(=O)Nc2cccc(CNc3ncnc4c(C(N)=O)cc(O)cc34)c2)cc1 CHEMBL3685307 IC50 0.6 nM
CC(Nc1ncnc2c(C(N)=O)cccc12)c1cccc(NC(=O)c2ccc(CN(C)C)cc2)c1 CHEMBL3685268 IC50 0.62 nM
CC(Nc1ncnc2c(C(N)=O)cccc12)c1cccc(NC(=O)C2=CCC(Br)C=C2)c1 CHEMBL3675466 IC50 0.66 nM
CC1(C)CC(NC(=O)c2ccc(Nc3ncc([N+](=O)[O-])c(Nc4ccc(C(=O)Nc5ccc(Cl)cc5)cc4)n3)cc2)CC(C)(C)N1[O] CHEMBL4516770 IC50 0.67 nM
NC(=O)C1=c2ncnc(NCc3cccc(NC(=O)c4ccc(C(F)(F)F)cc4)c3)c2=CCC1 CHEMBL3685308 IC50 0.68 nM
NC(=O)c1cccc2c(NCc3ccc(F)c(NC(=O)c4ccc(Br)cc4)c3)ncnc12 CHEMBL3675506 IC50 0.69 nM
O=C(Nc1ccc(Nc2ccnc3[nH]c(=O)c4ccccc4c23)cc1)c1cc(F)cc(F)c1 CHEMBL2380833 IC50 0.7 nM
NC(=O)c1cccc2c(NCc3cccc(NC(=O)c4ccc(Br)cc4)c3)ncnc12 CHEMBL3670468 IC50 0.71 nM
NC(=O)c1cccc2c(NCc3cccc(NC(=O)c4ccc(CO)cc4)c3)ncnc12 CHEMBL3680571 IC50 0.73 nM
CN(C)c1cccc(C(=O)Nc2cccc(CNc3ncnc4c(C(N)=O)cccc34)c2)n1 CHEMBL3670498 IC50 0.73 nM
NCc1cnc(Nc2cccc(CNc3ncnc4c(C(N)=O)cccc34)c2)s1 CHEMBL3680551 IC50 0.74 nM
N#CCc1ccc(Nc2cccc(CNc3ncnc4c(C(N)=O)cccc34)c2)nc1 CHEMBL3680577 IC50 0.76 nM
NC(=O)c1cccc2c(NCc3cccc(NC(=O)c4cccc(Br)c4)c3)ncnc12 CHEMBL3685251 IC50 0.79 nM
Nc1ncc(-c2cnn(CCO)c2)c2scc(-c3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12 CHEMBL1980297 pKi 0.7943 nM
CCS(=O)(=O)c1ccc(-c2ccc(-c3n[nH]c4c3Cc3cc(O)c(OC)cc3-4)cc2)cc1 CHEMBL1992195 pKi 0.7943 nM
CCC(=O)Nc1ccc(Sc2nc(Nc3cc(C)[nH]n3)cc(N3CCN(C(C)(C)C)CC3)n2)cc1 CHEMBL484006 Ki 0.8 nM
O=C(Nc1ccc(Nc2ccnc3[nH]c(=O)c4ccccc4c23)cc1)c1ccc(F)c(F)c1 CHEMBL2380832 IC50 0.8 nM
COc1ccc(C(=O)Nc2cc(CNc3ncnc4c(C(N)=O)cccc34)ccc2C)cc1 CHEMBL3685267 IC50 0.8 nM
NC(=O)c1cccc2c(NCc3cccc(NC(=O)c4ccc(N5CCCCC5)nc4)c3)ncnc12 CHEMBL3685293 IC50 0.81 nM
C[C@@H](Nc1ncnc2c(C(N)=O)cccc12)c1ccccc1 CHEMBL3675380 IC50 0.82 nM
NC(=O)c1cccc2c(NC(CCN3CCCCC3)c3cccc(NC(=O)c4ccc(Br)cc4)c3)ncnc12 CHEMBL3680507 IC50 0.82 nM
NC(=O)c1cccc2c(NCc3cccc(NC(=O)c4c(F)cccc4F)c3)ncnc12 CHEMBL3685266 IC50 0.88 nM
CC(Nc1ncnc2c(C(N)=O)cccc12)c1cccc(NC(=O)c2ccc3c(c2)OCCO3)c1 CHEMBL3675520 IC50 0.89 nM
Nc1ncnn2ccc(C(=O)Nc3cccc(CNC(=O)Nc4ccc(Cl)cc4)c3)c12 CHEMBL2063459 IC50 0.9 nM
Cc1cc(C(=O)Nc2cccc(C(C)Nc3ncnc4c(C(N)=O)cccc34)c2)c(C(F)(F)F)o1 CHEMBL3680474 IC50 0.94 nM
CN(C)c1ccc(C(=O)Nc2cccc(CNc3ncnc4c(C(N)=O)cccc34)c2)cn1 CHEMBL3670497 IC50 0.94 nM
COCCC(Nc1ncnc2c(C(N)=O)cccc12)c1cccc(NC(=O)c2ccc(OC)cc2)c1 CHEMBL3680499 IC50 0.94 nM
NC(=O)c1cccc2c(NCc3cccc(Nc4ccccn4)c3)ncnc12 CHEMBL3680542 IC50 0.94 nM
COc1ccc(C(=O)Nc2cccc(CNc3ncnc4c(C(N)=O)cc(CO)cc34)c2)cc1 CHEMBL3680567 IC50 0.96 nM
Cc1cc(Nc2ncc(C)c(N3CC(O)(C4CC4)C3)n2)sn1 CHEMBL5434489 IC50 0.97 nM
COc1cc2c(Nc3cc(CC(=O)Nc4cccc(F)c4F)[nH]n3)ncnc2cc1OCCCN1CCC[C@@H]1CO CHEMBL385049 Ki 1.0 nM
COc1cc2c(Nc3cc(CC(=O)Nc4cccc(F)c4)[nH]n3)ncnc2cc1OCCCN1CCC[C@@H]1CO CHEMBL424899 Ki 1.0 nM
COc1cc2c(Nc3cc(CC(=O)Nc4cccc(F)c4)[nH]n3)ncnc2cc1OCCCNCCO CHEMBL386253 Ki 1.0 nM
CCN(CCO)CCCOc1cc2ncnc(Nc3cc(CC(=O)Nc4cccc(F)c4)[nH]n3)c2cc1OC CHEMBL215275 Ki 1.0 nM
COc1cc2c(Nc3cnc(NC(=O)c4ccccc4)nc3)ncnc2cc1OCCCN1CCOCC1 CHEMBL381724 IC50 1.0 nM
O=C(Nc1ccccc1)Nc1ccc(-c2nn(CC(O)CO)cc2-c2ccnc3[nH]ccc23)cc1 CHEMBL1097106 IC50 1.0 nM
Cc1cc(Nc2nc(Sc3ccc(NC(=O)CN4C[C@H](O)[C@@H](F)C4)cc3)nn3cccc23)n[nH]1 CHEMBL1822648 Kd 1.0 nM
COc1ccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(CC(O)CO)c5)cnc(N)c34)cc2)cc1 CHEMBL1965170 pKi 1.0 nM
C[C@@H](O)Cn1cc(-c2cnc(N)c3c(-c4ccc(NC(=O)Nc5cccc(F)c5)cc4)csc23)cn1 CHEMBL2022856 IC50 1.0 nM
CN1CCC(n2cc(-c3cnc(N)c4c(-c5ccc(NC(=O)Nc6cccc(F)c6)cc5)csc34)cn2)C1=O CHEMBL2022855 EC15 1.0 nM
Cc1ccc(NC(=O)NCc2cccc(NC(=O)c3ccn4ncnc(N)c34)c2)cc1 CHEMBL2063461 IC50 1.0 nM
COc1cccc(F)c1C(=O)Nc1ccc(Nc2ccnc3[nH]c(=O)c4ccccc4c23)cc1 CHEMBL2380838 IC50 1.0 nM
O=C(Nc1ccc(Nc2ccnc3[nH]c(=O)c4ccccc4c23)cc1)c1cccc(C(F)(F)F)c1F CHEMBL2380835 IC50 1.0 nM
O=C(Nc1ccc(Nc2ccnc3[nH]c(=O)c4ccccc4c23)cc1)c1ccc(F)cc1F CHEMBL2380830 IC50 1.0 nM
O=C(Nc1ccc(Nc2ccnc3[nH]c(=O)c4ccccc4c23)cc1)c1ccc(F)cc1 CHEMBL2380827 IC50 1.0 nM
O=C(Nc1ccc(Nc2ccnc3[nH]c(=O)c4ccccc4c23)cc1)c1cccc(F)c1 CHEMBL2380825 IC50 1.0 nM
O=C(Nc1ccc(Nc2ccnc3[nH]c(=O)c4ccccc4c23)cc1)c1ccccc1C(F)(F)F CHEMBL2380824 IC50 1.0 nM
O=C(Nc1ccc(Nc2ccnc3[nH]c(=O)c4ccccc4c23)cc1)c1ccccc1 CHEMBL2380845 IC50 1.0 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL388978 IC50 1.0 nM
CCOC(=O)c1[nH]cc2c1NC1=C(C(=O)CCC1)[C@H]2c1cccc(Oc2nc3ccccc3[nH]2)c1 CHEMBL3393498 IC50 1.0 nM
COc1ccc(C(=O)Nc2cccc(C(CCN(C)C)Nc3ncnc4c(C(N)=O)cccc34)c2)cc1 CHEMBL3680476 IC50 1.0 nM
NC(=O)c1cccc2c(NCc3cccc(Nc4nccs4)c3)ncnc12 CHEMBL3680548 IC50 1.0 nM
NC(=O)c1cccc2c(NCc3cccc(NC(=O)c4ccc(-c5ncc[nH]5)cc4)c3)ncnc12 CHEMBL3680556 IC50 1.0 nM
COCCN(C)CCCOc1cc(C(N)=O)c2ncnc(NCc3ccc(C(F)(F)F)cc3)c2c1 CHEMBL3670504 IC50 1.0 nM
NC(=O)c1cccc2c(NCc3cccc(NC(=O)C4CCCCC4)c3)ncnc12 CHEMBL3685248 IC50 1.1 nM
CN(C)CCC(Nc1ncnc2c(C(N)=O)cccc12)c1cccc(NC(O)c2cc(C3CC3)n[nH]2)c1 CHEMBL3680470 IC50 1.1 nM
NC(=O)c1cccc2c(NCc3cccc(NC(=O)c4cncc(N5CCCC5)c4)c3)ncnc12 CHEMBL3675453 IC50 1.1 nM
Cc1cc(Nc2ncc(C)c(N3CCC(CC#N)CC3)n2)sn1 CHEMBL5434965 IC50 1.1 nM
CC1(C)CC(NC(=O)c2ccc(Nc3ncc(F)c(Nc4ccccc4Cl)n3)cc2)CC(C)(C)N1[O] CHEMBL4451940 IC50 1.11 nM
COc1ccc(NC(=O)Nc2ccc3c(c2)NC(=O)/C3=C\c2[nH]cc(C(=O)O)c2C)cc1 CHEMBL1173411 IC50 1.19 nM
COc1ccc(C(=O)NC(=O)Nc2ccc3c(c2)NC(=O)/C3=C\c2[nH]c(C)c(CCC(=O)O)c2C)cc1 CHEMBL3329669 IC50 1.2 nM
NC(=O)c1cccc2c(NCc3cccc(NC(=O)c4cn[nH]c4N)c3)ncnc12 CHEMBL3680549 IC50 1.2 nM
Cc1ccccc1C(=O)Nc1cccc(CNc2ncnc3c(C(N)=O)cccc23)c1 CHEMBL3685241 IC50 1.2 nM
NC(=O)c1cccc2c(NCc3cccc(NC(=O)c4ccc5c(c4)OCO5)c3)ncnc12 CHEMBL3670471 IC50 1.2 nM
CC(Nc1ncnc2c(C(N)=O)cccc12)c1cccc(NC(=O)c2ccc(Cl)c(F)c2)c1 CHEMBL3675491 IC50 1.2 nM
NC(=O)c1cccc2c(NCc3cccc(NC(=O)c4ccc(SC(F)(F)F)cc4)c3)ncnc12 CHEMBL3670474 IC50 1.2 nM
Nc1ncnc2sc3c(c12)-c1ccc(NC(=O)Nc2cccc(C(F)(F)F)c2)cc1CC3 CHEMBL1985523 pKi 1.259 nM
Cc1cccc(Nc2nccc(Nc3ccccc3C(=O)O)n2)c1 CHEMBL243517 pKi 1.259 nM
COc1ccc(C(=O)NC(=O)Nc2ccc3c(c2)NC(=O)/C3=C\c2[nH]c(C)c(CCC(=O)O)c2C)c(F)c1 CHEMBL3329673 IC50 1.3 nM
COCCC(Nc1ncnc2c(C(N)=O)cccc12)c1cccc(NC(=O)c2ccc(C(F)(F)F)cc2)c1 CHEMBL3675480 IC50 1.3 nM
CC(Nc1ncnc2c(C(N)=O)cccc12)c1cccc(NC(=O)c2cc(C(C)(C)C)n[nH]2)c1 CHEMBL3675465 IC50 1.3 nM
CCNC(=O)Nc1ccc(-c2nn(CC)cc2-c2ccnc3[nH]c(-c4cccc(CN5CCCC5)c4)cc23)cc1 CHEMBL1095475 IC50 1.4 nM
CN(C)CC(Nc1ncnc2c(C(N)=O)cccc12)c1cccc(NC(=O)c2ccnc(N3CCCC3)c2)c1 CHEMBL3675406 IC50 1.4 nM
NC[C@@H](Nc1ncnc2c(C(N)=O)cccc12)c1ccccc1 CHEMBL3670464 IC50 1.4 nM
NC(=O)C1=c2ncnc(NC(CCN3CCCC3)c3cccc(NC(=O)c4ccc(Br)cc4)c3)c2=CCC1 CHEMBL3680390 IC50 1.4 nM
CCC(Nc1ncnc2c(C(N)=O)cccc12)c1cccc(NC(=O)c2ccc(C(F)(F)F)nc2)c1 CHEMBL3675487 IC50 1.4 nM
CCNC(=O)Nc1ccc(-c2nn(CC)cc2-c2ccnc3[nH]c(-c4ccc(CN5CCCC5)cc4)cc23)cc1 CHEMBL1097191 IC50 1.5 nM
COc1ccc(C(=O)NC(=O)Nc2cc3c(cc2F)/C(=C/c2[nH]c(C)c(CCC(=O)O)c2C)C(=O)N3)c(F)c1 CHEMBL3329675 IC50 1.5 nM
COc1ccc(C(=O)NC(=O)Nc2cc3c(cc2F)/C(=C/c2[nH]c(C)c(C(=O)O)c2C)C(=O)N3)cc1 CHEMBL3329670 IC50 1.5 nM
NC(=O)c1cccc2c(NCc3cccc(F)c3)ncnc12 CHEMBL3675337 IC50 1.5 nM
CS(=O)(=O)c1ccc(C(=O)Nc2cccc(CNc3ncnc4c(C(N)=O)cccc34)c2)cc1 CHEMBL3680481 IC50 1.5 nM
NC(=O)c1cccc2c(NC(CCN3CCCCC3)c3cccc(NC(O)c4ccccc4)c3)ncnc12 CHEMBL3685286 IC50 1.5 nM
NC(=O)c1cccc2c(NC(CCN3CCCCC3)c3cccc(Nc4ccccn4)c3)ncnc12 CHEMBL3685214 IC50 1.5 nM
COc1ccc(C(=O)Nc2cccc(C(CCN3CCCCC3)Nc3ncnc4c(C(N)=O)cccc34)c2)cc1 CHEMBL3685294 IC50 1.5 nM
NC(=O)c1cccc2c(NCc3cccc(NC(=O)Nc4ccccc4)c3)ncnc12 CHEMBL3675371 IC50 1.5 nM
COc1cc(Nc2ncc3c(n2)-c2ccc(Cl)cc2C(c2c(F)cccc2OC)=NC3)ccc1C(=O)O CHEMBL483158 IC50 1.5 nM
Cc1cc(Nc2ncc(C)c(N3CCN(CC#N)CC3)n2)sn1 CHEMBL5402554 IC50 1.5 nM
Cc1cc(Nc2ncc(C)c(N3CC4CCC(C3)N4CCC#N)n2)sn1 CHEMBL5405344 IC50 1.5 nM
Cc1cccc(NC(=O)Nc2ccc(-c3nn(C)c4ncnc(N)c34)cc2)c1 CHEMBL1982837 pKi 1.585 nM
NC(=O)c1cccc2c(NCc3cccc(NC(=O)Cc4ccc(Cl)cc4)c3)ncnc12 CHEMBL3670478 IC50 1.6 nM
NC(=O)c1cccc2c(NCc3cccc(NC(=O)c4cnn5c4CNCC5)c3)ncnc12 CHEMBL3685210 IC50 1.6 nM
NC(=O)c1cc(OCCCNCCO)cc2c(NCc3ccc(C(F)(F)F)cc3)ncnc12 CHEMBL3675325 IC50 1.6 nM
NC(=O)c1cccc2c(NCc3cccc(NC(=O)C4CCCNC4)c3)ncnc12 CHEMBL3685254 IC50 1.6 nM
CN(C)CCC(Nc1ncnc2c(C(N)=O)cccc12)c1cccc(NC(=O)c2ccc(C(F)(F)F)cc2)c1 CHEMBL3675449 IC50 1.6 nM
CCNC(=O)Nc1ccc(-c2nn(CC)cc2-c2ccnc3[nH]c(-c4ccc(CN(C)C)cc4)cc23)cc1 CHEMBL1094838 IC50 1.7 nM
Cc1cc(Nc2nc(Sc3ccc(NC(=O)CN4CC[C@@H](C(=O)N5CCC(F)(F)C5)C4)cc3)nn3cccc23)n[nH]1 CHEMBL2163404 Kd 1.7 nM
Cc1cc(Nc2nc(Sc3ccc(NC(=O)CN4CC[C@@H](OCCO)C4)cc3)nn3cccc23)n[nH]1 CHEMBL2163407 Kd 1.7 nM
COc1cc(C(N)=O)c2ncnc(NCc3cccc(NC(=O)c4ccc(F)cc4)c3)c2c1 CHEMBL3670476 IC50 1.7 nM
CN(C)c1cccc(C(=O)Nc2cccc(CNc3ncnc4c3=CCCC=4C(N)=O)c2)c1 CHEMBL3685242 IC50 1.7 nM
Cc1cc(Nc2cc(N3CCN(C)CC3)nc(Sc3ccc(NC(=O)C4CC4)cc3)n2)n[nH]1 CHEMBL572878 Ki 1.8 nM
COc1ccc(C(=O)NC(=O)Nc2ccc3c(c2)NC(=O)/C3=C\c2[nH]c(C)c(CC(=O)O)c2C)cc1 CHEMBL3329668 IC50 1.8 nM
COc1ccc(C(=O)Nc2cccc(CNc3ncnc4c(C(N)=O)cccc34)c2)cc1C(F)(F)F CHEMBL3680532 IC50 1.8 nM
C=CCN(C)CCC(Nc1ncnc2c(C(N)=O)cccc12)c1cccc(NC(=O)c2ccc(OC)cc2)c1 CHEMBL3675516 IC50 1.8 nM
CCOc1ccc(C(=O)Nc2cccc(CNc3ncnc4c(C(N)=O)cccc34)c2)cc1 CHEMBL3685247 IC50 1.8 nM
NC(=O)c1cccc2c(NCc3ccc(F)c(NC(=O)c4ccc(OC(F)(F)F)cc4)c3)ncnc12 CHEMBL3685287 IC50 1.8 nM
Cc1cc(Nc2nc(Sc3ccc(NC(=O)CN4CC[C@@H](C(=O)NC5CCCC5)C4)cc3)nn3cccc23)n[nH]1 CHEMBL2163394 Kd 1.9 nM
Cc1cc(Nc2nc(Sc3ccc(NC(=O)CN4CC[C@H](C(=O)N5CCCC5)C4)cc3)nn3cccc23)n[nH]1 CHEMBL2163402 Kd 1.9 nM
COc1ccc(C(=O)NC(=O)Nc2ccc3c(c2)NC(=O)/C3=C\c2[nH]c(C)c(C(=O)O)c2C)cc1 CHEMBL3329664 IC50 1.9 nM
COc1ccc(C(=O)Nc2cccc(C(CN(C)C)Nc3ncnc4c3=CCCC=4C(N)=O)c2)cc1F CHEMBL3675431 IC50 1.9 nM
CC(C)N1CCC(C(=O)Nc2cccc(CNC3=NC=NC4C(C(N)=O)=CCC=C34)c2)CC1 CHEMBL3685222 IC50 1.9 nM
CN(C)CCC(Nc1ncnc2c(C(N)=O)cccc12)c1cccc(NC(=O)c2ccccc2)c1 CHEMBL3685255 IC50 1.9 nM
O=C(O)c1ccccc1Nc1nc(Nc2cccc(O)c2)ncc1F CHEMBL243749 pKi 1.995 nM
CNC1CC2OC(C)(C1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL1980995 pKi 1.995 nM
O=C(O)c1ccccc1Nc1ccnc(Nc2ccc(O)cc2)n1 CHEMBL243297 pKi 1.995 nM
CCCN(CCO)CCCOc1cc2ncnc(Nc3cc(CC(=O)Nc4cccc(F)c4)[nH]n3)c2cc1OC CHEMBL217804 Ki 2.0 nM
COc1cc2c(Nc3cc(CC(=O)Nc4cccc(F)c4)[nH]n3)ncnc2cc1OCCCN1CCC(CO)CC1 CHEMBL216769 IC50 2.0 nM
Cc1[nH]nc2c1CCCc1c-2[nH]c2cc3c(cc12)NC(=O)C3(C)C CHEMBL469205 IC50 2.0 nM
CCn1cc(-c2ccnc3[nH]ccc23)c(-c2ccc(NC(=O)Nc3ccccc3)cc2)n1 CHEMBL1089116 IC50 2.0 nM
O=C(Nc1ccccc1)Nc1ccc(-c2nn(CCCO)cc2-c2ccnc3[nH]ccc23)cc1 CHEMBL1097454 IC50 2.0 nM
COc1cc(Nc2nccc(-c3sc(C)nc3C)n2)cc(OC)c1OC CHEMBL1083151 Ki 2.0 nM
Cc1cc(Nc2nc(Sc3ccc(NC(=O)CN4C[C@H](OCC5CC5)[C@@H](O)C4)cc3)nn3cccc23)n[nH]1 CHEMBL1822653 Kd 2.0 nM
COCCO[C@H]1CN(CC(=O)Nc2ccc(Sc3nc(Nc4cc(C)[nH]n4)c4cccn4n3)cc2)C[C@@H]1O CHEMBL1822651 Kd 2.0 nM
Nc1ncc(-c2cnn(CCCN3CC[C@@H](O)C3)c2)c2scc(-c3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12 CHEMBL2022857 IC50 2.0 nM
Cc1ccccc1NC(=O)Nc1ccc(-c2csc3c(-c4cnn(C)c4)cnc(N)c23)cc1 CHEMBL2023225 EC15 2.0 nM
Cc1ccc(C(=O)Nc2ccc(Nc3ccnc4[nH]c(=O)c5ccccc5c34)cc2)cc1 CHEMBL2380826 IC50 2.0 nM
O=C(Nc1ccc(Nc2ccnc3[nH]c(=O)c4ccccc4c23)cc1)c1ccccc1F CHEMBL2380823 IC50 2.0 nM
COc1ccccc1C(=O)Nc1ccc(Nc2ccnc3[nH]c(=O)c4ccccc4c23)cc1 CHEMBL2380839 IC50 2.0 nM
CC(=O)N[C@@H]1CCN(c2c(Cl)cnc3[nH]c(-c4cn(C)nc4C)nc23)C1 CHEMBL3087777 IC50 2.0 nM
CCOC(=O)c1[nH]cc2c1NC1=C(C(=O)CN(C(=O)CN)C1)[C@H]2c1ccc(Sc2nc3c(F)cccc3[nH]2)o1 CHEMBL3393486 IC50 2.0 nM
CCOC(=O)c1[nH]cc2c1NC1=C(C(=O)CNC1)C2c1ccc(Sc2nc3ccccc3[nH]2)o1 CHEMBL3393472 IC50 2.0 nM
COC(=O)c1[nH]cc2c1NC1=C(C(=O)CCC1)C2c1ccc(Sc2nc3ccccc3[nH]2)o1 CHEMBL3393470 IC50 2.0 nM
CCOC(=O)c1[nH]cc2c1NC1=C(C(=O)CCC1)C2c1cc(Sc2nc3ccccc3[nH]2)cs1 CHEMBL3393065 IC50 2.0 nM
NC(=O)c1cccc2c(NCc3cccc(NC(=O)c4ccccc4F)c3)ncnc12 CHEMBL3685280 IC50 2.0 nM
CCOC(=O)c1cnc(Nc2cccc(CNc3ncnc4c(C(N)=O)cccc34)c2)s1 CHEMBL3680544 IC50 2.0 nM
NC(=O)c1cccc2c(NCc3cccc(NC(=O)c4cccc(OC(F)(F)F)c4)c3)ncnc12 CHEMBL3685258 IC50 2.0 nM
CCn1cc(-c2ccnc3[nH]c(-c4cccc(CN5CCCC5)c4)cc23)c(-c2ccc(NC(=O)N(C)C)cc2)n1 CHEMBL1095788 IC50 2.1 nM
NC(=O)c1cccc2c(NCc3cccc(NC(=O)Cc4ccccc4)c3)ncnc12 CHEMBL3670472 IC50 2.1 nM
CCOc1cc(C(=O)Nc2cccc(C(C)Nc3ncnc4c(C(N)=O)cccc34)c2)ccn1 CHEMBL3680480 IC50 2.1 nM
NC(=O)c1cccc2c(NCc3cccc(NC(=O)c4ccnc(N5CCCC5)c4)c3)ncnc12 CHEMBL3680392 IC50 2.1 nM
Cc1cc(Nc2nc(Sc3ccc(NC(=O)CN4CC[C@@H](C(=O)NCC(F)(F)F)C4)cc3)nn3cccc23)n[nH]1 CHEMBL2163388 Kd 2.2 nM
CS(=O)(=O)c1nc(Cl)cc(Nc2c[nH]nc2-c2nc3cc(CN4CCOCC4)ccc3[nH]2)n1 CHEMBL2392111 IC50 2.2 nM
NC(=O)c1cccc2c(NCc3cccc(NC(=O)N4CCCCC4)c3)ncnc12 CHEMBL3670465 IC50 2.2 nM
Cc1cc(C(=O)Nc2cccc(CNc3ncnc4c(C(N)=O)cccc34)c2)ccc1N1CCOCC1 CHEMBL3680557 IC50 2.2 nM
CN(C)CCC(Nc1ncnc2c(C(N)=O)cccc12)c1cccc(NC(=O)c2ccc(OC(F)(F)F)cc2)c1 CHEMBL3680395 IC50 2.2 nM
O=C1Nc2ccccc2/C1=C/c1c[nH]nc1-c1ccccc1[N+](=O)[O-] CHEMBL2347053 IC50 2.3 nM
Cc1ccc2[nH]c(-c3n[nH]cc3Nc3cc(Cl)nc(S(C)(=O)=O)n3)nc2c1 CHEMBL2392112 IC50 2.3 nM
COc1ccc(C(=O)NC(=O)Nc2ccc3c(c2)NC(=O)/C3=C\c2[nH]c(C)c(C(=O)O)c2C)c(F)c1 CHEMBL3329672 IC50 2.3 nM
COc1ccc(C(=O)NC2=CC(C(CCN(C)C)Nc3ncnc4c(C(N)=O)cccc34)=CCC2)c(F)c1 CHEMBL3680391 IC50 2.3 nM
NC(=O)c1cccc2c(NCc3cccc(NC(=O)c4ccnc(N5CCCCC5)c4)c3)ncnc12 CHEMBL3680464 IC50 2.3 nM
COc1cc(C(=O)NC2=CCCC(C(C)Nc3ncnc4c(C(N)=O)cccc34)=C2)ccn1 CHEMBL3680436 IC50 2.3 nM
Cc1cc(C(=O)Nc2cccc(CNc3ncnc4c(C(N)=O)cccc34)c2)[nH]n1 CHEMBL3685240 IC50 2.3 nM
NC(=O)c1cccc2c(NCc3cccc(NC(=O)c4ccc(N5CCOCC5)c(C(F)(F)F)c4)c3)ncnc12 CHEMBL3680582 IC50 2.3 nM
Cc1cc(Nc2nc(Sc3ccc(NC(=O)CN4CCC(C(=O)N5CCCC5)C4)cc3)nn3cccc23)n[nH]1 CHEMBL2163398 Kd 2.4 nM
CN(C)C[C@@H](Nc1ncnc2c(C(N)=O)cccc12)c1ccccc1 CHEMBL3675442 IC50 2.4 nM
N#Cc1ccc(C(=O)Nc2cccc(CNc3ncnc4c(C(N)=O)cccc34)c2)cc1 CHEMBL3685261 IC50 2.4 nM
CC(Nc1ncnc2c(C(N)=O)cccc12)c1cccc(NC(=O)c2ccccc2)c1 CHEMBL3680388 IC50 2.4 nM
Cc1cc(Nc2nc(Sc3ccc(NC(=O)CN4CC[C@@H](C(=O)N5CCCC5)C4)cc3)nn3cccc23)n[nH]1 CHEMBL2163403 Kd 2.5 nM
NC(=O)C1=c2ncnc(NC(CCN3CCCC3)c3cccc(NC(=O)c4ccccc4)c3)c2=CCC1 CHEMBL3680531 IC50 2.5 nM
NC(=O)c1cccc2c(NCc3cccc(Nc4nc5ccccc5s4)c3)ncnc12 CHEMBL3680597 IC50 2.5 nM
CN(C)CCC(Nc1ncnc2c(C(N)=O)cccc12)C1=CCCC(NC(=O)c2cccc(F)c2F)=C1 CHEMBL3675504 IC50 2.5 nM
COc1ccccc1NC(=O)Nc1cccc(CNc2ncnc3c(C(N)=O)cccc23)c1 CHEMBL3670424 IC50 2.5 nM
COc1cc(OC)c(F)c(N2Cc3cnc4[nH]c(-c5cnn(C)c5)cc4c3N(C)C2=O)c1F CHEMBL4871581 IC50 2.5 nM
Cc1cc(Nc2ncc(C)c(N3CC4CCCC(C3)N4CCC#N)n2)sn1 CHEMBL5404765 IC50 2.5 nM
Cc1cc(Nc2ncc(C)c(-c3cnn(CCC#N)c3)n2)sn1 CHEMBL5423027 IC50 2.5 nM
O=C(Nc1ccc(-n2cnc3ccccc32)cc1)Nc1cccc(C(F)(F)F)c1 CHEMBL1993510 pKi 2.512 nM
CCN(CC)CCCNC(=O)c1cnc(N)c2c(-c3ccc(NC(=O)Nc4cccc(F)c4)cc3)csc12 CHEMBL1996649 pKi 2.512 nM
NS(=O)(=O)c1cccc(Nc2ncc3ccn(-c4ccccc4)c3n2)c1 CHEMBL1988163 pKi 2.512 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(C#CCNS(C)(=O)=O)cnc(N)c34)cc2)c1 CHEMBL1994321 pKi 2.512 nM
CCN(CC)CCCNC(=O)c1cnc(N)c2c(-c3ccc(NC(=O)Nc4cccc(C)c4)cc3)csc12 CHEMBL1999414 pKi 2.512 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(C#CCN)cnc(N)c34)cc2)c1 CHEMBL1965988 pKi 2.512 nM
Cc1nc(N)sc1-c1ccnc(Nc2ccc(N3CCOCC3)cc2)n1 CHEMBL482967 pKi 2.512 nM
CC1(C)CC(NC(=O)c2ccc(Nc3ncc(F)c(Nc4ccc(C(=O)Nc5ccccc5Cl)cc4)n3)cc2)CC(C)(C)N1[O] CHEMBL4563026 IC50 2.55 nM
O=C(Nc1c[nH]nc1-c1nc2cc(CN3CCOCC3)ccc2[nH]1)Nc1c(F)cccc1F CHEMBL458421 IC50 2.6 nM
Cc1cc(Nc2nc(Sc3ccc(NC(=O)CN4CC[C@@H](C(=O)N5CCOCC5)C4)cc3)nn3cccc23)n[nH]1 CHEMBL2163390 Kd 2.6 nM
CN(C)c1cc(C(=O)Nc2cccc(CNc3ncnc4c(C(N)=O)cccc34)c2)ccn1 CHEMBL3639693 IC50 2.6 nM
CC1(C)CC(NC(=O)c2ccc(Nc3ncc(Br)c(Nc4ccccc4Cl)n3)cc2)CC(C)(C)N1[O] CHEMBL4471448 IC50 2.67 nM
O=C(Nc1c[nH]nc1-c1nc2ccc(CN3CCOCC3)cc2[nH]1)NC1CC1 CHEMBL495727 IC50 2.7 nM
COCCOc1cc(C(N)=O)c2ncnc(NCc3cccc(NC(=O)c4ccc(OC)cc4)c3)c2c1 CHEMBL3685244 IC50 2.7 nM
COc1ccc(C(=O)Nc2ccc(F)c(CNc3ncnc4c(C(N)=O)cccc34)c2)cc1 CHEMBL3685265 IC50 2.7 nM
COc1ccc(C(=O)Nc2cccc(C(CCN3CCCC3)Nc3ncnc4c(C(N)=O)cccc34)c2)cc1 CHEMBL3685288 IC50 2.8 nM
CCCCOC(=O)Cc1cc(Nc2nc(Nc3ccc(C(=O)NC4CC(C)(C)N([O])C(C)(C)C4)cc3)ncc2F)n[nH]1 CHEMBL4443086 IC50 2.8 nM
Cc1cc(Nc2nc(Sc3ccc(NC(=O)CN4CC[C@@H](C(=O)NCCN5CCOCC5)C4)cc3)nn3cccc23)n[nH]1 CHEMBL2163392 Kd 2.9 nM
Cc1cc(Nc2nc(Sc3ccc(NC(=O)CN4CC[C@@H](C(=O)N5CCCCC5)C4)cc3)nn3cccc23)n[nH]1 CHEMBL2163389 Kd 2.9 nM
Cc1cc(Nc2nc(Sc3ccc(NC(=O)CN4CC[C@@H](OCCN5CCN(C)CC5)C4)cc3)nn3cccc23)n[nH]1 CHEMBL2163410 Kd 2.9 nM
Cc1[nH]c(/C=C2\C(=O)Nc3cc(NC(=O)c4c[nH]cc(-c5ccc(F)cc5)c4=O)ccc32)c(C)c1C(=O)N1CCOCC1 CHEMBL3322595 IC50 2.9 nM
NC(=O)c1cccc2c(NCc3cccc(NC(=O)c4cccc(Cl)n4)c3)ncnc12 CHEMBL3670487 IC50 2.9 nM
Cn1cc(-c2ccc3c(Nc4cccc(NC(=O)Nc5ccccc5F)c4)ncnc3c2)cn1 CHEMBL4799497 IC50 2.981 nM
O=C(Nc1ccccc1)Nc1ccc(-c2nn(CCO)cc2-c2ccnc3[nH]ccc23)cc1 CHEMBL1099010 IC50 3.0 nM
CCNC(=O)Nc1ccc(-c2nn(CC)cc2-c2ccnc3[nH]c(-c4cccc(CN(C)C)c4)cc23)cc1 CHEMBL1095157 IC50 3.0 nM
CNc1nc(C)c(-c2ccnc(Nc3cc(OC)c(OC)c(OC)c3)n2)s1 CHEMBL1083152 Ki 3.0 nM
Cn1cc(Nc2ncc3cnn([C@@H]4C[C@H]5C[C@H]5C4)c3n2)cc1C(=O)N1CCC[C@H]1CO CHEMBL2012409 IC50 3.0 nM
Nc1noc2cccc(C(=O)Nc3cccc(CNC(=O)Nc4ccc(Cl)cc4)c3)c12 CHEMBL2063444 IC50 3.0 nM
CCS(=O)(=O)Nc1ccc2c(c1)/C(=C(/Nc1ccc(CN3CCCCC3)cc1)c1ccccc1)C(=O)N2 CHEMBL514409 IC50 3.0 nM
COc1ccc(C(=O)NC(=O)Nc2cc3c(cc2F)/C(=C/c2[nH]c(C)c(C(=O)O)c2C)C(=O)N3)c(F)c1 CHEMBL3329674 IC50 3.0 nM
COc1ccc(C(=O)NC(=O)Nc2cc3c(cc2F)/C(=C/c2[nH]c(C)c(CCC(=O)O)c2C)C(=O)N3)cc1 CHEMBL3329671 IC50 3.0 nM
CCOC(=O)c1[nH]cc2c1NC1=C(C(=O)CNC1)C2c1ccc(Sc2nc3c(F)cccc3[nH]2)o1 CHEMBL3393488 IC50 3.0 nM
CCOC(=O)c1[nH]cc2c1NC1=C(C(=O)CCC1)C2c1ccc(Sc2nc3ccccc3[nH]2)o1 CHEMBL3393469 IC50 3.0 nM
COc1ccc(C(O)/N=C2\C=CCC(CNc3ncnc4c(C(N)=O)cccc34)C2)cc1C CHEMBL3680429 IC50 3.0 nM
NC(=O)c1cccc2c(NCc3cccc(NC(=O)c4ccc(F)c(F)c4)c3)ncnc12 CHEMBL3670473 IC50 3.0 nM
CCNC(=O)C#Cc1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(CN(C)C)cc1)c1ccccc1 CHEMBL3699142 IC50 3.0 nM
Cc1cc(Nc2ncc(C)c(N3CCN(CC#N)C(C)C3)n2)sn1 CHEMBL5429675 IC50 3.0 nM
Cc1cc(Nc2ncc(C)c(N3CC(CCC#N)C3)n2)sn1 CHEMBL5432284 IC50 3.0 nM
CC1(C)CC(NC(=O)c2ccc(Nc3ncc([N+](=O)[O-])c(Nc4ccc(C(=O)Nc5ccccc5Cl)cc4)n3)cc2)CC(C)(C)N1[O] CHEMBL4442043 IC50 3.07 nM
Cc1cc(Nc2nc(Sc3ccc(NC(=O)CN4CC[C@@H](C(=O)NC(C)(C)C)C4)cc3)nn3cccc23)n[nH]1 CHEMBL2163387 Kd 3.1 nM
Cc1cc(Nc2nc(Sc3ccc(NC(=O)CN4CC[C@@H]([S+]([O-])C(C)(C)C)C4)cc3)nn3cccc23)n[nH]1 CHEMBL2163400 Kd 3.1 nM
COCCO[C@@H]1CCN(CC(=O)Nc2ccc(Sc3nc(Nc4cc(C)[nH]n4)c4cccn4n3)cc2)C1 CHEMBL2163408 Kd 3.1 nM
COCCC(Nc1ncnc2c(C(N)=O)cccc12)c1cccc(NC(=O)c2ccc(F)c(F)c2)c1 CHEMBL3675538 IC50 3.1 nM
Nc1ncnc2c1N=C(c1ccc(NC(=O)Nc3cccc(C(F)(F)F)c3)cc1)CCN2 CHEMBL260092 pKi 3.162 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(C#CC(C)(C)N)cnc(N)c34)cc2)c1 CHEMBL1979577 pKi 3.162 nM
N#CCOc1ccc(Nc2nc(Nc3cccc(S(N)(=O)=O)c3)ncc2Br)cc1 CHEMBL1987034 pKi 3.162 nM
CN(C)C(=O)C=Cc1ccc(-c2ccc(NC(=O)Nc3cccc(C(F)(F)F)c3)cc2)c2c(N)n[nH]c12 CHEMBL1972472 pKi 3.162 nM
COCCOC1CCC(n2nc(-c3ccc(Nc4nc5cc(Br)cc(C)c5o4)cc3)c3c(N)ncnc32)CC1 CHEMBL1972851 pKi 3.162 nM
COc1ccc(-c2ccc(NC(=O)Nc3cc(F)cc(F)c3)cc2)c2c(N)noc12 CHEMBL1969190 pKi 3.162 nM
Cc1cc(Nc2nc(Sc3ccc(NC(=O)CN4CC[C@@H](NS(C)(=O)=O)C4)cc3)nn3cccc23)n[nH]1 CHEMBL2163396 Kd 3.2 nM
CC1(C)CC(NC(=O)c2ccc(Nc3ncc([N+](=O)[O-])c(Nc4ccccc4Cl)n3)cc2)CC(C)(C)N1[O] CHEMBL4520619 IC50 3.29 nM
Cc1cc(Nc2nc(Sc3ccc(NC(=O)CN4CC[C@@H](C(=O)NC5CCC5)C4)cc3)nn3cccc23)n[nH]1 CHEMBL2163395 Kd 3.3 nM
CC(Nc1ncnc2c(C(N)=O)cccc12)c1cccc(NC(=O)c2ccc(CN3CCCC3)cc2)c1 CHEMBL3685285 IC50 3.3 nM
NC(=O)c1cccc2c(NCc3cccc(Nc4ncccn4)c3)ncnc12 CHEMBL3685212 IC50 3.3 nM
Cc1cc(Nc2cc(N3CCN(N)CC3)nc(Sc3ccc(NC(=O)C4CC4)cc3)n2)n[nH]1 CHEMBL5407522 Ki 3.36 nM
O=C(Nc1ccc(CCNc2n[nH]c(=O)c3ccccc23)cc1)NC1CCCCC1 CHEMBL4761521 IC50 3.4 nM
COCCN(C)c1cc(C(=O)Nc2cccc(CNc3ncnc4c(C(N)=O)cccc34)c2)ccn1 CHEMBL3680411 IC50 3.5 nM
CC1(C)CC(NC(=O)c2ccc(Nc3ncc([N+](=O)[O-])c(Nc4cccc(O)c4)n3)cc2)CC(C)(C)N1[O] CHEMBL4440617 IC50 3.5 nM
CC1(C)CC(NC(=O)c2ccc(Nc3ncc([N+](=O)[O-])c(Nc4ccc(O)cc4)n3)cc2)CC(C)(C)N1[O] CHEMBL4447241 IC50 3.5 nM
CCn1cc(-c2ccnc3[nH]c(-c4ccc(CN(C)C)cc4)cc23)c(-c2ccc(NC(=O)N(C)C)cc2)n1 CHEMBL1095149 IC50 3.6 nM
Cc1cc(Nc2nc(Sc3ccc(NC(=O)CN4CC[C@@H](OC(C)(C)C)C4)cc3)nn3cccc23)n[nH]1 CHEMBL2163412 Kd 3.6 nM
COc1ccc(C(=O)Nc2cccc(CNc3ncnc4c(C(N)=O)cccc34)c2)c(OC)c1 CHEMBL3680509 IC50 3.6 nM
Cc1cc(Nc2nc(Sc3ccc(NC(=O)CN4CC[C@@H](C(=O)N5CCC(O)CC5)C4)cc3)nn3cccc23)n[nH]1 CHEMBL2163391 Kd 3.7 nM
Cc1cc(Nc2nc(Sc3ccc(NC(=O)CN4CC[C@@H](OCCCN5CCOCC5)C4)cc3)nn3cccc23)n[nH]1 CHEMBL2163411 Kd 3.7 nM
CC(=O)N1CCN(c2ccc(Nc3nccc(-c4sc(N)nc4C)n3)cc2)CC1 CHEMBL1084969 Ki 3.8 nM
NC(=O)c1cccc2c(NCc3cccc(NC(=O)c4ccccc4C(F)(F)F)c3)ncnc12 CHEMBL3685309 IC50 3.8 nM
NC(=O)c1cccc2c(NCc3cc(F)cc(F)c3)ncnc12 CHEMBL3670427 IC50 3.9 nM
NC(=O)c1cccc2c(NCc3ccc4c(c3)OCO4)ncnc12 CHEMBL3675353 IC50 3.9 nM
Cc1ccc(-c2cnc(N)c3c(-c4ccc(NC(=O)Nc5cccc(F)c5)cc4)csc23)cn1 CHEMBL1988075 pKi 3.981 nM
O=C(O)c1ccccc1Nc1ccnc(Nc2ccc3[nH]ncc3c2)n1 CHEMBL396523 pKi 3.981 nM
COc1ccc(-c2ccc(NC(=O)Nc3ccc(F)c(C)c3)cc2)c2c(N)noc12 CHEMBL1979093 pKi 3.981 nM
O=S(=O)(Nc1ccc2c(c1)C(=NO)c1ccccc1-2)c1cccc(Cl)c1 CHEMBL1999910 pKi 3.981 nM
Nc1ncnc2c1N=C(c1ccc(NC(=O)Nc3cc(C(F)(F)F)ccc3F)cc1)CCN2 CHEMBL411903 pKi 3.981 nM
COCCOC1CCC(n2nc(-c3ccc(Nc4nc5cc(C)cc(C)c5o4)cc3)c3c(N)ncnc32)CC1 CHEMBL1984162 pKi 3.981 nM
O=C1Nc2ccc3ncsc3c2C1=CNc1ccc(S(=O)(=O)Nc2ccccn2)cc1 CHEMBL1973540 pKi 3.981 nM
O=C(Nc1cccc(-c2nc3sccn3c2-c2ccnc(Nc3cccc(N4CCCC4=O)c3)n2)c1)c1c(F)cccc1F CHEMBL2006715 pKi 3.981 nM
CCNc1nc(C)c(-c2ccnc(Nc3ccc(CNC(C)=O)cc3)n2)s1 CHEMBL1084715 Ki 4.0 nM
Cc1cc(Nc2nc(Sc3ccc(NC(=O)CN4C[C@H](OC5CCCC5)[C@@H](O)C4)cc3)nn3cccc23)n[nH]1 CHEMBL1822654 Kd 4.0 nM
Cc1cc(Nc2nc(Sc3ccc(NC(=O)CN4C[C@H](OC(C)C)[C@@H](O)C4)cc3)nn3cccc23)n[nH]1 CHEMBL1822652 Kd 4.0 nM
CCC(C)(C)O[C@H]1CN(CC(=O)Nc2ccc(Sc3nc(Nc4cc(C)[nH]n4)c4cccn4n3)cc2)C[C@@H]1O CHEMBL1822650 Kd 4.0 nM
Cc1cc(Nc2nc(Sc3ccc(NC(=O)CN4C[C@H](OC(C)(C)C(F)(F)F)[C@@H](O)C4)cc3)nn3cccc23)n[nH]1 CHEMBL1822649 Kd 4.0 nM
Cc1cc(Nc2nc(Sc3ccc(NC(=O)CN4C[C@@H](F)C[C@H]4CO)cc3)nn3cccc23)n[nH]1 CHEMBL1822640 Kd 4.0 nM
Cc1cc(Nc2nc(Sc3ccc(NC(=O)CN4CCC[C@H]4CO)cc3)nn3cccc23)n[nH]1 CHEMBL1822495 Kd 4.0 nM
Cc1cc(Nc2nc(Sc3ccc(NC(=O)C4CC4)cc3)nn3cc(NC(=O)C(=O)N4CCN(C)CC4)cc23)n[nH]1 CHEMBL1822490 Kd 4.0 nM
Nc1cccc(-c2nc3c(NCCCNC(=O)C4CCC4)c(Br)cnc3[nH]2)c1 CHEMBL2011940 IC50 4.0 nM
Cn1cc(Nc2ncc3cnn([C@@H]4C[C@H]5C[C@H]5C4)c3n2)cc1C(N)=O CHEMBL2012402 IC50 4.0 nM
CN(C)C(=O)[C@@H]1CCCN1C(=O)c1cc(Nc2ncc3cnn([C@@H]4C[C@H]5C[C@H]5C4)c3n2)cn1C CHEMBL2012404 IC50 4.0 nM
C[C@@H]1CCCN1C(=O)c1cc(Nc2ncc3cnn([C@@H]4C[C@H]5C[C@H]5C4)c3n2)cn1C CHEMBL2012406 IC50 4.0 nM
Cn1cc(Nc2ncc3cnn([C@@H]4C[C@H]5C[C@H]5C4)c3n2)cc1C(=O)N1CCC[C@H]1C(N)=O CHEMBL2012408 IC50 4.0 nM
Cn1cc(Nc2ncc3cnn([C@@H]4C[C@H]5C[C@H]5C4)c3n2)cc1C(=O)N1CCC[C@H]1CN1CCOCC1 CHEMBL2012412 IC50 4.0 nM
Cn1cc(Nc2ncc3cnn([C@@H]4C[C@H]5C[C@H]5C4)c3n2)cc1C(=O)N1CCC[C@@H]1CN1CCOCC1 CHEMBL2012415 IC50 4.0 nM
CCCn1cc(-c2cnc(N)c3c(-c4ccc(NC(=O)Nc5cccc(F)c5)cc4)csc23)cn1 CHEMBL1993941 EC15 4.0 nM
CS(=O)(=O)CCn1cc(-c2cnc(N)c3c(-c4ccc(NC(=O)Nc5cccc(F)c5)cc4)csc23)cn1 CHEMBL2022853 EC15 4.0 nM
CN1CCN(C(=O)c2cc(Nc3ncc4cc(C#N)n(C5CCCC5)c4n3)cn2C)CC1 CHEMBL2029901 IC50 4.0 nM
CN1CCN(C(=O)c2cc(Nc3ncc4cc(-c5cnco5)n(C5CCCC5)c4n3)cn2C)CC1 CHEMBL2029908 IC50 4.0 nM
CN1CCN(C(=O)c2cc(Nc3ncc4cc(-c5cnn(C)c5)n(C5CCCC5)c4n3)cn2C)CC1 CHEMBL2029909 IC50 4.0 nM
Cc1c(-c2cc3cnc(Nc4cc(C(=O)N5CCN(C)CC5)n(C)c4)nc3n2C2CCCC2)cnn1C CHEMBL2029911 IC50 4.0 nM
CC(C)CCn1cc(-c2cc3cnc(Nc4cc(C(=O)N5CCN(C)CC5)n(C)c4)nc3n2C2CCCC2)cn1 CHEMBL2029912 IC50 4.0 nM
CN1CCN(C(=O)c2cc(Nc3ncc4cc(-c5ccnn5C)n(C5CCCC5)c4n3)cn2C)CC1 CHEMBL2029913 IC50 4.0 nM
CN1CCN(C(=O)c2cc(Nc3ncc4cc(-c5cnn(Cc6ccccc6)c5)n(C5CCCC5)c4n3)cn2C)CC1 CHEMBL2029914 IC50 4.0 nM
Nc1ncnn2ccc(C(=O)Nc3cccc(CNC(=O)Nc4cccc(F)c4)c3)c12 CHEMBL2063462 IC50 4.0 nM
Cc1ccc(NC(=O)NCc2cccc(NC(=O)c3cccc4onc(N)c34)c2)cc1 CHEMBL2063443 IC50 4.0 nM
CCOC(=O)c1[nH]cc2c1NC1=C(C(=O)CN(C(=O)CN)C1)[C@H]2c1ccc(Sc2nc3ccccc3[nH]2)o1 CHEMBL3393485 IC50 4.0 nM
CCOC(=O)c1[nH]cc2c1NC1=C(C(=O)CCC1)C2c1ccc(Sc2nc3c(F)cc(F)cc3[nH]2)o1 CHEMBL3393475 IC50 4.0 nM
NC(=O)c1cc(OCCCN2CCN(CCO)CC2)cc2c(NCc3ccc(C(F)(F)F)cc3)ncnc12 CHEMBL3670505 IC50 4.0 nM
CC(C)c1cc(CNc2nc(Nc3cc(C4CC4)[nH]n3)cc(N3CCN(C)CC3)n2)on1 CHEMBL3545085 Kd apparent 4.0 nM
Cc1csc(-c2nnc(Nc3ccc(Oc4ncccc4-c4ccnc(N)n4)cc3)c3ccccc23)c1 CHEMBL2140408 IC50 4.0 nM
Nc1nc(Nc2ccc(S(N)(=O)=O)cc2)nn1C(=O)c1c(F)cccc1F CHEMBL191003 IC50 4.0 nM
Cc1nc(-c2ccccc2Nc2nc(Nc3ccc(CN4CCN(C)CC4)cc3)ncc2Cl)n[nH]1 CHEMBL5169760 IC50 4.0 nM
Cc1cc(Nc2ncc(C)c(N3CC4CCC(C3)N4CC#N)n2)sn1 CHEMBL5402797 IC50 4.0 nM
NC(=O)c1cccc(CNc2ncnc3c(C(N)=O)cccc23)c1 CHEMBL3670445 IC50 4.1 nM
CC(Nc1ncnc2c(C(N)=O)cccc12)c1cccc(NC(=O)CC(F)(F)F)c1 CHEMBL3680602 IC50 4.2 nM
Cc1ccc2c(c1)C(=O)N(C)c1cnc(Nc3ccc(S(N)(=O)=O)cc3)nc1N2C CHEMBL3950648 IC50 4.2 nM
Cc1cc(Nc2nc(Sc3ccc(NC(=O)CN4CC[C@@H](S(=O)(=O)C(C)(C)C)C4)cc3)nn3cccc23)n[nH]1 CHEMBL2163401 Kd 4.3 nM
Cc1cccc(NC(=O)Nc2cccc(CNc3ncnc4c(C(N)=O)cccc34)c2)c1 CHEMBL3670454 IC50 4.3 nM
CN(C)CCC(Nc1ncnc2c(C(N)=O)cccc12)c1cccc(NC(=O)c2ccc(F)cc2F)c1 CHEMBL3675445 IC50 4.3 nM
Cc1cc(C(F)(F)F)nn1CC(=O)Nc1cccc(CNc2ncnc3c(C(N)=O)cccc23)c1 CHEMBL3685215 IC50 4.4 nM
CCn1cc(-c2ccnc3[nH]c(-c4ccc(CN5CCCC5)cc4)cc23)c(-c2ccc(NC(=O)N(C)C)cc2)n1 CHEMBL1097521 IC50 4.5 nM
COc1ccc(-c2c[nH]cc(C(=O)Nc3ccc4c(c3)NC(=O)/C4=C\c3[nH]c(C)c(C(=O)O)c3C)c2=O)cc1 CHEMBL3322592 IC50 4.5 nM
NC(=O)c1cccc2c(NC(CCN3CCC3)c3cccc(NC(=O)c4ccc(Br)cc4)c3)ncnc12 CHEMBL3675518 IC50 4.5 nM
COc1ccccc1C(=O)Nc1cccc(CNc2ncnc3c(C(N)=O)cccc23)c1 CHEMBL3685259 IC50 4.6 nM
CN1C(=O)c2ccccc2N(C)c2nc(Nc3cccc(S(N)(=O)=O)c3)ncc21 CHEMBL3904942 IC50 4.6 nM
CCn1cc(-c2ccnc3[nH]c(-c4cccc(CN5CCOCC5)c4)cc23)c(-c2ccc(NC(=O)N(C)C)cc2)n1 CHEMBL1094701 IC50 4.7 nM
CCNC(=O)Nc1ccc(-c2nn(CC)cc2-c2ccnc3[nH]c(-c4ccc(CN5CCOCC5)cc4)cc23)cc1 CHEMBL1094702 IC50 4.7 nM
NC(=O)c1cccc2c(NCc3cccc(NC(=O)c4ccc5nc[nH]c5c4)c3)ncnc12 CHEMBL3680578 IC50 4.7 nM
NC(=O)c1cccc2c(Nc3cccc(CNC(=O)c4ccc(C(F)(F)F)cc4)c3)ncnc12 CHEMBL3680605 IC50 4.7 nM
CCCN1CCC=C(c2ccc(Nc3nc(Nc4ccccc4C(N)=O)c4cc[nH]c4n3)cc2)C1 CHEMBL476451 IC50 5.0 nM
CCN1C(=O)C(C)(C)c2cc3[nH]c4c(c3cc21)CCCc1c(C)n[nH]c1-4 CHEMBL223147 IC50 5.0 nM
FC(F)(F)c1cnc2[nH]c(Nc3ccc(CCNc4ncnc5ccsc45)cc3)nc2c1 CHEMBL1079538 IC50 5.0 nM
CCNC(=O)Nc1ccc(-c2nn(CC)cc2-c2ccnc3[nH]c(-c4cccc(CN5CCOCC5)c4)cc23)cc1 CHEMBL1094700 IC50 5.0 nM
CCn1cc(-c2ccnc3[nH]c(C(=O)NCCN4CCOCC4)cc23)c(-c2ccc(NC(=O)Nc3ccccc3)cc2)n1 CHEMBL1094704 IC50 5.0 nM
CCn1cc(-c2ccnc3[nH]c(C(=O)NCCN4CCN(C)CC4)cc23)c(-c2ccc(NC(=O)Nc3ccccc3)cc2)n1 CHEMBL1094706 IC50 5.0 nM
Cc1cc(Nc2nc(Sc3ccc(NC(=O)CN4CC(=NO)[C@@H](OC(C)(C)C)C4)cc3)nn3cccc23)n[nH]1 CHEMBL1822655 Kd 5.0 nM
Cc1cc(Nc2nc(Sc3ccc(NC(=O)CN4C[C@H](OC(C)(C)C)[C@@H](O)C4)cc3)nn3cccc23)n[nH]1 CHEMBL1822647 Kd 5.0 nM
Cc1cc(Nc2nc(Sc3ccc(NC(=O)CN4CC(F)(F)C[C@H]4CO)cc3)nn3cccc23)n[nH]1 CHEMBL1822638 Kd 5.0 nM
Cn1cc(Nc2ncc3cnn(C4CCC5(CC4)CC5)c3n2)cc1C(N)=O CHEMBL2012400 IC50 5.0 nM
Cn1cc(Nc2ncc3cnn(C4CCC(C)(C)CC4)c3n2)cc1C(N)=O CHEMBL2012401 IC50 5.0 nM
Cn1cc(Nc2ncc3cnn([C@@H]4C[C@H]5C[C@H]5C4)c3n2)cc1C(=O)N1CCC[C@H]1CN1CCCC1 CHEMBL2012410 IC50 5.0 nM
COC[C@@H]1CCCN1C(=O)c1cc(Nc2ncc3cnn([C@@H]4C[C@H]5C[C@H]5C4)c3n2)cn1C CHEMBL2012411 IC50 5.0 nM
CN1CCN(C(=O)c2cc(Nc3ncc4cc(-c5cncn5C)n(C5CCCC5)c4n3)cn2C)CC1 CHEMBL2029910 IC50 5.0 nM
CCOC(=O)c1[nH]cc2c1NC1=C(C(=O)CNC1)C2c1ccc(Sc2nc3cccc(Cl)c3[nH]2)o1 CHEMBL3393487 IC50 5.0 nM
COC(=O)c1csc2c1NC1=C(C(=O)CCC1)C2c1ccc(Sc2nc3ccccc3[nH]2)o1 CHEMBL3393467 IC50 5.0 nM
O=C1CCCC2=C1C(c1ccc(Sc3nc4ccccc4[nH]3)o1)c1cn[nH]c1N2 CHEMBL3393462 IC50 5.0 nM
NC(=O)c1cccc2c(NC(CCN3CCCC3)c3cccc(Nc4ccccn4)c3)ncnc12 CHEMBL3685221 IC50 5.0 nM
NC(=O)c1cccc2c(NCc3cccc(Nc4nc5ccc(C(F)(F)F)cc5[nH]4)c3)ncnc12 CHEMBL3685275 IC50 5.0 nM
NC(=O)c1cccc2c(NCC3CC=C/C(=N/C(O)c4ccn[nH]4)C3)ncnc12 CHEMBL4114796 IC50 5.0 nM
NC(=O)c1cccc2c(NCc3cccc(NC(=O)c4n[nH]c5ccc(Cl)cc45)c3)ncnc12 CHEMBL3685217 IC50 5.0 nM
NC(=O)c1cccc2c(NCc3ccco3)ncnc12 CHEMBL3670417 IC50 5.0 nM
CC(=O)NCC(=O)N1[C@@H]2CC[C@H]1c1ccc(Nc3ncc(C(F)(F)F)c(NC4CCC4)n3)cc12 CHEMBL4289017 IC50 5.0 nM
Nc1ncc(-c2ccoc2)c2scc(-c3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12 CHEMBL1966514 pKi 5.012 nM
Cc1ccc(Nc2nccc(Nc3ccccc3C(=O)O)n2)cc1F CHEMBL243518 pKi 5.012 nM
O=C(Nc1cccc(-c2nn3ccccc3c2-c2ccnc(Nc3ccc4c(c3)CNCC4)n2)c1)c1c(F)cccc1F CHEMBL1969834 pKi 5.012 nM
COc1ccc(Nc2nccc(Nc3ccccc3C(=O)O)n2)cc1O CHEMBL1964519 pKi 5.012 nM
O[C@H]1CC[C@H](Nc2nc(Nc3ncc(Cc4ccccc4)s3)cc(C(F)(F)c3ccc(F)cc3)n2)CC1 CHEMBL2441283 pKi 5.012 nM
O=C(Nc1c[nH]nc1-c1nc2cc(CN3CCOCC3)ccc2[nH]1)NC1CCCCC1 CHEMBL496754 IC50 5.2 nM
O=C(NC(=O)c1ccccc1)Nc1ccc2c(c1)NC(=O)/C2=C\c1ccc[nH]1 CHEMBL3329655 IC50 5.3 nM
COc1ccc(C(=O)Nc2cccc(CNc3ncnc4c(C(N)=O)cc(OCCCN(C)C)cc34)c2)cc1 CHEMBL3685297 IC50 5.3 nM
COCCC(Nc1ncnc2c(C(N)=O)cccc12)c1cccc(NC(=O)c2ccc(OC(F)(F)F)cc2)c1 CHEMBL3680479 IC50 5.3 nM
NC(=O)c1cccc2c(NCc3cccc(NC(=O)c4cccc(N5CCOCC5)c4)c3)ncnc12 CHEMBL3680590 IC50 5.5 nM
NC(=O)c1cccc2c(NCc3cccc(NC(=O)Nc4cccc(F)c4)c3)ncnc12 CHEMBL3670425 IC50 5.6 nM
Cc1cc(Nc2nc(Sc3ccc(NC(=O)CN4CC[C@@H](NC(=O)C(C)C)C4)cc3)nn3cccc23)n[nH]1 CHEMBL2163413 Kd 5.7 nM
CN1CCN(c2ccc(C(=O)Nc3cccc(CNc4nncc5c(C(N)=O)cccc45)c3)cc2C(F)(F)F)CC1 CHEMBL3680492 IC50 5.8 nM
COc1ccc(NC(=O)CC(=O)Nc2ccc3c(c2)NC(=O)/C3=C\c2[nH]c(C)c(C(=O)O)c2C)cc1 CHEMBL3322565 IC50 5.9 nM
CN(C)CCC(Nc1ncnc2c(C(N)=O)cccc12)C1=CCCC(NC(=O)c2c(F)cccc2F)=C1 CHEMBL3680418 IC50 5.9 nM
Cc1ccc2[nH]ccc2c1-c1nc(C(N)=O)c(-c2ccc(N3CCNC(C)(C)C3)cc2)o1 CHEMBL3970921 IC50 5.9 nM
Cc1cc(F)c2[nH]ccc2c1-c1nc(C(N)=O)c(-c2ccc(N3CCNC(C)(C)C3)cc2)o1 CHEMBL3917983 IC50 5.93 nM
FC(F)(F)c1ccc2[nH]c(Nc3ccc(CCNc4ncnc5ccsc45)cc3)nc2c1 CHEMBL1077729 IC50 6.0 nM
CCNc1nc(C)c(-c2ccnc(Nc3ccc(N4CCOCC4)cc3)n2)s1 CHEMBL1084630 Ki 6.0 nM
CCNc1nc(C)c(-c2ccnc(Nc3cc(OC)c(OC)c(OC)c3)n2)s1 CHEMBL1086088 Ki 6.0 nM
COC[C@H]1CCCN1C(=O)c1cc(Nc2ncc3cnn([C@@H]4C[C@H]5C[C@H]5C4)c3n2)cn1C CHEMBL2012414 IC50 6.0 nM
Cn1cc(-c2cnc(N)c3c(-c4ccc(NC(=O)Nc5ccccc5)cc4)csc23)cn1 CHEMBL2023226 IC50 6.0 nM
Cn1cc(-c2cnc(N)c3c(-c4ccc(NC(=O)Nc5cccc(F)c5)cc4)csc23)cn1 CHEMBL1970317 EC15 6.0 nM
O=C(Nc1ccc(Nc2ccnc3[nH]c(=O)c4ccccc4c23)cc1)c1ccc(C(F)(F)F)cc1 CHEMBL2380828 IC50 6.0 nM
CCOC(=O)c1[nH]cc2c1NC1=C(C(=O)CN(CC)C1)C2c1ccc(Sc2nc3ccccc3[nH]2)o1 CHEMBL3393484 IC50 6.0 nM
CCOC(=O)c1[nH]cc2c1NC1=C(C(=O)CCC1)C2c1ccc(Sc2nc3cc(F)c(F)cc3[nH]2)o1 CHEMBL3393476 IC50 6.0 nM
CCOC(=O)c1[nH]cc2c1NC1=C(C(=O)CCC1)C2c1ccc(Sc2nc3cccc(F)c3[nH]2)o1 CHEMBL3393474 IC50 6.0 nM
COc1ccc(C(=O)Nc2cccc(C(CCN3CCC3)Nc3ncnc4c(C(N)=O)cccc34)c2)cc1 CHEMBL3685289 IC50 6.0 nM
Cc1cc(Nc2ncc(C)c(N3CC(CC#N)C3)n2)sn1 CHEMBL5417435 IC50 6.0 nM
Cc1cc(Nc2nc(Sc3ccc(NC(=O)CN4CCC(C(=O)C(C)(C)C)C4)cc3)nn3cccc23)n[nH]1 CHEMBL2163397 Kd 6.1 nM
CN1CCN(CCCOc2cc(C(N)=O)c3ncnc(NCc4ccc(C(F)(F)F)cc4)c3c2)CC1 CHEMBL3675323 IC50 6.2 nM
COc1cccc(S(=O)(=O)Nc2ccc3c(c2)C(=NO)c2ccccc2-3)c1 CHEMBL1971271 pKi 6.31 nM
Cc1cc(N=Cc2ccc(O)c(O)c2)c2ccccc2n1 CHEMBL1991915 pKi 6.31 nM
Nc1nccc2scc(-c3ccc(NC(=O)Nc4ccccc4C(F)(F)F)cc3)c12 CHEMBL1987910 pKi 6.31 nM
O=S(=O)(Nc1ccc2c(c1)C(=NO)c1ccccc1-2)c1cccc(F)c1 CHEMBL1987658 pKi 6.31 nM
Cc1cc(C)cc(NC(=O)Nc2ccc(-c3c(C)sc4ncnc(N)c34)cc2)c1 CHEMBL371206 pKi 6.31 nM
COc1cc(Nc2ncc([N+](=O)[O-])c(Nc3ccccc3C(N)=O)n2)cc(OC)c1OC CHEMBL1241473 pKi 6.31 nM
CCN1CCN(c2ccc(Nc3nccc(-c4c(-c5cccc(C(=O)Nc6ccccc6F)c5)nc5ccccn45)n3)cc2)CC1 CHEMBL1981725 pKi 6.31 nM
CN(C)Cc1ccc(/C=C/c2n[nH]c3cc([C@@H]4C[C@@]45C(=O)Nc4ccccc45)ccc23)cc1 CHEMBL3353347 IC50 6.4 nM
NC(=O)c1cccc2c(NCc3cccc(NC(=O)c4n[nH]c5ccc(Br)cc45)c3)ncnc12 CHEMBL3685230 IC50 6.4 nM
O=C(NC(=O)c1ccccc1F)Nc1ccc2c(c1)NC(=O)/C2=C\c1ccc[nH]1 CHEMBL3329658 IC50 6.5 nM
O=C(NC(=O)c1ccc(Cl)cc1)Nc1ccc2c(c1)NC(=O)/C2=C\c1ccc[nH]1 CHEMBL3329656 IC50 6.5 nM
CCN(CC)CCOc1cc(C(N)=O)c2ncnc(NCc3cccc(NC(=O)c4ccc(OC)cc4)c3)c2c1 CHEMBL3685239 IC50 6.5 nM
CC(Nc1ncnc2c(C(N)=O)cccc12)c1cccc(NC(=O)C2CC(F)(F)C2)c1 CHEMBL3680574 IC50 6.5 nM
Cc1cc(Nc2nc(Sc3ccc(NC(=O)CN4CC[C@@H](OCCN5CCOCC5)C4)cc3)nn3cccc23)n[nH]1 CHEMBL2163409 Kd 6.6 nM
Cc1cc(Nc2nc(Sc3ccc(NC(=O)CN4CC[C@@H](O)C4)cc3)nn3cccc23)n[nH]1 CHEMBL2163406 Kd 6.6 nM
CC(Nc1ncnc2c(C(N)=O)cccc12)c1cccc(NC(=O)c2ccc(=O)[nH]c2)c1 CHEMBL3680601 IC50 6.8 nM
Cc1cc(Nc2nc(Sc3ccc(NC(=O)CN4CC[C@@H](C(=O)Nc5ccc(F)cc5)C4)cc3)nn3cccc23)n[nH]1 CHEMBL2163393 Kd 6.9 nM
NC(=O)c1cccc2c(NCc3cccc(NC(=O)C4=CCC(N5CCOCC5)C=C4)c3)ncnc12 CHEMBL3685256 IC50 6.9 nM
COc1ccc2c(c1)[C@]1(C[C@H]1c1ccc3c(-c4ccc(N5CCN(C)CC5)cc4)n[nH]c3c1)C(=O)N2 CHEMBL4448596 IC50 6.9 nM
COc1ccc2c(c1)[C@]1(C[C@H]1c1ccc3c(-c4ccc(N5CCNCC5)cc4)n[nH]c3c1)C(=O)N2 CHEMBL4553351 IC50 6.9 nM
COc1cc2c(Nc3ncc(CC(=O)Nc4cccc(F)c4)s3)ncnc2cc1OCCCN1CCC(CO)CC1 CHEMBL201307 IC50 7.0 nM
COc1ccc(-c2nc3c(NCCCN(C)C(=O)C4CCC4)c(Br)cnc3[nH]2)cc1 CHEMBL2011934 IC50 7.0 nM
Nc1noc2cccc(C(=O)Nc3cccc(CNC(=O)Nc4ccc(F)c(F)c4)c3)c12 CHEMBL2063448 IC50 7.0 nM
CC(=O)NC[C@@H]1CCN(c2c(Cl)cnc3[nH]c(-c4cn(C)nc4C)nc23)C1 CHEMBL3087778 IC50 7.0 nM
CCOC(=O)c1[nH]cc2c1NC1=C(C(=O)CCC1)C2c1ccc(Sc2nc3cccc(Cl)c3[nH]2)o1 CHEMBL3393479 IC50 7.0 nM
CCOC(=O)c1[nH]cc2c1NC1=C(C(=O)CCC1)C2c1ccc(Sc2nc3c(F)c(F)c(F)cc3[nH]2)o1 CHEMBL3393478 IC50 7.0 nM
CCOC(=O)c1[nH]cc2c1NC1=C(C(=O)CCC1)C2c1ccc(Sc2nc3ccc(F)c(F)c3[nH]2)o1 CHEMBL3393477 IC50 7.0 nM
CCOC(=O)c1[nH]cc2c1NC1=C(C(=O)CCC1)C2c1cccc(Sc2nc3ccccc3[nH]2)n1 CHEMBL3393495 IC50 7.0 nM
CCOC(=O)c1[nH]cc2c1NC1=C(C(=O)CCC1)C2c1cccc(Sc2nc3ccccc3[nH]2)c1 CHEMBL3393494 IC50 7.0 nM
COc1ccc2c(c1)[C@]1(C[C@H]1c1ccc3c(-c4ccc(N5CCN(CCO)CC5)cc4)n[nH]c3c1)C(=O)N2 CHEMBL4470693 IC50 7.0 nM
Cc1cnc(Nc2cnn(C)c2)nc1-c1cnn([C@H](CC#N)C2CCCC2)c1 CHEMBL5395308 IC50 7.0 nM
COc1ccccc1C(CNC(C)=O)Nc1ncnc2c(C(N)=O)cccc12 CHEMBL3675330 IC50 7.1 nM
C=CC(=O)Nc1ccc(C(=O)Nc2ccc(Nc3ncc4c(n3)N(C)c3ccc(C)cc3C(=O)N4C)cc2)cc1 CHEMBL3969370 EC50 7.1 nM
O=C1Nc2ccccc2[C@]12C[C@H]2c1ccc2c(/C=C/c3ccncc3)n[nH]c2c1 CHEMBL3353340 IC50 7.4 nM
CCN(CCO)CCCOc1ccc2c(Nc3cc(CC(=O)Nc4cccc(F)c4F)[nH]n3)ncnc2c1 CHEMBL215322 IC50 7.5 nM
CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3cc(NC(=O)NC(=O)c4ccc(OC)cc4F)ccc32)c1C CHEMBL3329683 IC50 7.6 nM
NC(=O)c1cccc2c(NCc3ccccc3C(F)(F)F)ncnc12 CHEMBL3675352 IC50 7.6 nM
COCC[C@H](Nc1ncnc2c(C(N)=O)cccc12)c1cccc(NC(=O)c2ccc(OC)cc2)c1 CHEMBL3685274 IC50 7.6 nM
c1ccc(-c2csc3ncnc(N4CCc5ccccc5C4)c23)cc1 CHEMBL1483261 IC50 7.665 nM
O=C(NC(=O)c1ccc(Cl)c(Cl)c1)Nc1ccc2c(c1)NC(=O)/C2=C\c1ccc[nH]1 CHEMBL3329657 IC50 7.7 nM
CN(C)CCC(Nc1ncnc2c(C(N)=O)cccc12)C1=CCCC(NC(=O)c2ccccc2F)=C1 CHEMBL3680393 IC50 7.8 nM
CCOc1cc(C(N)=O)c2ncnc(NCc3cccc(NC(=O)c4ccc(F)cc4)c3)c2c1 CHEMBL3670479 IC50 7.8 nM
COc1ccc(NC(=O)Nc2ccc(-c3cccc4onc(N)c34)cc2)cc1Cl CHEMBL272453 pKi 7.943 nM
CNC(=O)c1ccccc1Sc1ccc2c(C=Cc3ccccn3)n[nH]c2c1 CHEMBL1988437 pKi 7.943 nM
COCCOC1CCC(n2nc(-c3ccc(Nc4nc5cc(Cl)cc(C)c5o4)c(F)c3)c3c(N)ncnc32)CC1 CHEMBL1988769 pKi 7.943 nM
Nc1nccc2scc(-c3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12 CHEMBL231209 pKi 7.943 nM
Cc1oc2ncnc(N)c2c1-c1ccc(NC(=O)Nc2cc(C(F)(F)F)ccc2F)cc1 CHEMBL2003604 pKi 7.943 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(C#Cc5cccnc5)cnc(N)c34)cc2)c1 CHEMBL1971947 pKi 7.943 nM
CNCC#Cc1cnc(N)c2c(-c3ccc(NC(=O)Nc4cccc(C)c4)cc3)csc12 CHEMBL1964441 pKi 7.943 nM
CCC(=O)Nc1ccc(Sc2nc(Nc3cc(C)[nH]n3)cc(N3CCCCC3)n2)cc1 CHEMBL484951 IC50 8.0 nM
Clc1ccc2[nH]c(Nc3ccc(CCNc4ncnc5ccsc45)cc3)nc2c1 CHEMBL1078060 IC50 8.0 nM
CCn1cc(-c2ccnc3[nH]c(C(=O)NCCCN4CCN(C)CC4)cc23)c(-c2ccc(NC(=O)Nc3ccccc3)cc2)n1 CHEMBL1094705 IC50 8.0 nM
Cc1cc(Nc2nc(Sc3ccc(NC(=O)CN4C[C@H](Oc5ccc(F)cc5)[C@@H](O)C4)cc3)nn3cccc23)n[nH]1 CHEMBL1822658 Kd 8.0 nM
Cc1cc(Nc2nc(Sc3ccc(NC(=O)CN4C[C@H](OC(C)(C)C)C[C@H]4CO)cc3)nn3cccc23)n[nH]1 CHEMBL1822637 Kd 8.0 nM
Cc1cc(Nc2nc(Sc3ccc(NC(=O)CN(C)C)cc3)nn3cccc23)n[nH]1 CHEMBL1822494 Kd 8.0 nM
Cc1cc(Nc2nc(Sc3ccc(NC(=O)CN4C[C@@H](O)[C@@H](Oc5ccc(F)cc5)C4)cc3)nn3cccc23)n[nH]1 CHEMBL1822661 Kd 8.0 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(-c5cn[nH]c5)cnc(N)c34)cc2)c1 CHEMBL1969102 IC50 8.0 nM
Nc1ncc(-c2cnn(CCN3CCCCC3)c2)c2scc(-c3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12 CHEMBL2022854 IC50 8.0 nM
Cn1cc(Nc2ncc(Cl)c(N[C@@H]3[C@H]4CC[C@H](C4)[C@@H]3C(N)=O)n2)cn1 CHEMBL2071210 IC50 8.0 nM
CCn1cc(Nc2ncc(Cl)c(N[C@H]3[C@@H](C(N)=O)[C@@H]4C=C[C@H]3C4)n2)cn1 CHEMBL2071216 IC50 8.0 nM
Cc1nn(C)cc1-c1nc2c(N3CCC[C@H](CNS(C)(=O)=O)C3)c(Cl)cnc2[nH]1 CHEMBL3087779 IC50 8.0 nM
CCOC(=O)c1[nH]cc2c1NC1=C(C(=O)CCC1)C2c1ccc(Sc2nc3c(O)cccc3[nH]2)o1 CHEMBL3393482 IC50 8.0 nM
CCOC(=O)c1[nH]cc2c1NC1=C(C(=O)CN(Cc3ccccc3)C1)C2c1ccc(Sc2nc3ccccc3[nH]2)o1 CHEMBL3393491 IC50 8.0 nM
CCn1cc(-c2ccnc3[nH]c(-c4ccc(CN5CCOCC5)cc4)cc23)c(-c2ccc(NC(=O)N(C)C)cc2)n1 CHEMBL1094703 IC50 8.1 nM
COc1cc(CNc2cncc3c(C(N)=O)cccc23)cc(OC)c1 CHEMBL3670416 IC50 8.2 nM
CCN1CCN(c2ccc(-c3n[nH]c4cc([C@@H]5C[C@@]56C(=O)Nc5ccc(OC)cc56)ccc34)cc2)CC1 CHEMBL4440812 IC50 8.5 nM
COc1ccc(C(=O)NCc2cccc(Nc3ncnc4c(C(N)=O)cc(O)cc34)c2)cc1 CHEMBL3685232 IC50 8.7 nM
COc1ccc(-c2nc(C(N)=O)c(-c3ccc(N4CCNC(C)(C)C4)cc3)o2)c2cc[nH]c12 CHEMBL3923418 IC50 8.78 nM
NC(=O)c1cccc2c(NCC3C=C(NC(=O)c4ccncc4)C=CC3)ncnc12 CHEMBL3685200 IC50 8.9 nM
CN(C)Cc1ccc(-c2cc3c(-c4cnn(C)c4)c(Cl)cnc3[nH]2)cc1 CHEMBL1090832 IC50 9.0 nM
CNc1nccc(-c2cccnc2Oc2ccc(Nc3nc4ccccc4[nH]3)c3ccccc23)n1 CHEMBL465793 IC50 9.0 nM
Cc1nc(C)c(-c2ccnc(Nc3ccc(N4CCOCC4)cc3)n2)s1 CHEMBL1085626 Ki 9.0 nM
CNc1nccc(-c2cccnc2Oc2ccc(NC(=O)c3ccccc3Nc3ccccc3)cc2)n1 CHEMBL1243200 IC50 9.0 nM
Cc1cc(Nc2nc(Sc3ccc(NC(=O)CN4C[C@H](Oc5ccccc5F)[C@@H](O)C4)cc3)nn3cccc23)n[nH]1 CHEMBL1822656 Kd 9.0 nM
Cc1cc(Nc2nc(Sc3ccc(NC(=O)CN4C[C@H](F)C[C@H]4CO)cc3)nn3cccc23)n[nH]1 CHEMBL1822639 Kd 9.0 nM
Cc1cc(Nc2nc(Sc3ccc(NC(=O)C4CC4)cc3)nn3cc(NC(=O)CN4CCOCC4)cc23)n[nH]1 CHEMBL1822487 Kd 9.0 nM
Nc1ncnn2ccc(C(=O)Nc3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12 CHEMBL1990583 IC50 9.0 nM
Cc1nn(C)cc1-c1nc2c(N3CCC[C@H](CN(C)S(C)(=O)=O)C3)c(Cl)cnc2[nH]1 CHEMBL3087781 IC50 9.0 nM
CN(C)CCC(Nc1ncnc2c(C(N)=O)cccc12)c1cccc(NC(=O)c2cc(F)ccc2F)c1 CHEMBL3680458 IC50 9.2 nM
O=C(O)c1ccc(Nc2ncc3c(n2)-c2ccc(Cl)cc2C(c2c(F)cccc2F)=NC3)cc1 CHEMBL259084 IC50 9.3 nM
CC1(C)CN(c2ccc(-c3oc(-c4ccc(F)c5[nH]ccc45)nc3C(N)=O)cc2)CCN1 CHEMBL3932362 IC50 9.36 nM
CNc1nc(C)c(-c2ccnc(Nc3ccc(N4CCOCC4)cc3)n2)s1 CHEMBL1084629 Ki 9.4 nM
CC(Nc1ncnc2c(C(N)=O)cccc12)C1=CC(NC(=O)C2(C(F)(F)F)CCC2)=CCC1 CHEMBL3680586 IC50 9.4 nM
COc1ccc(C(=O)Nc2cccc(CNc3ncnc4c(C(N)=O)cc(C(O)CO)cc34)c2)cc1 CHEMBL3962025 IC50 9.4 nM
CCC(=O)Nc1ccc(Sc2nc(Nc3cc(C)[nH]n3)cc(N3CCN(C4CC4)CC3)n2)cc1 CHEMBL485186 IC50 9.5 nM
NCC[C@@H](Nc1ncnc2c(C(N)=O)cccc12)c1ccccc1 CHEMBL3675478 IC50 9.6 nM
CNc1nc(C)c(-c2ccnc(Nc3ccc(N4CCN(C(C)=O)CC4)cc3)n2)s1 CHEMBL1083785 Ki 9.7 nM
COc1cccc(OC)c1C(=O)Nc1cccc(CNc2ncnc3c(C(N)=O)cccc23)c1 CHEMBL3685279 IC50 9.8 nM
CS(=O)(=O)c1ccc(-c2ccc3c(Nc4cccc(NC(=O)Nc5cccc(F)c5)c4)ncnc3c2)cc1 CHEMBL4796319 IC50 9.968 nM