COc1cc2c(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3F)ccnc2cc1OCCCN1CCOCC1 CHEMBL1230609 Kd 0.093 nM
Cn1cc(-c2ccc(NC(=O)c3cn(CC4CCOCC4)cc(-c4ccc(F)cc4)c3=O)cc2)c2c(N)ncnc21 CHEMBL4858468 IC50 0.1 nM
Cn1cc(-c2ccc(NC(=O)c3cn(CC4CCOCC4)cc(-c4ccc(Cl)cc4)c3=O)cc2)c2c(N)ncnc21 CHEMBL4855261 IC50 0.2 nM
Cn1cc(-c2ccc(NC(=O)c3cn(CC4CCOCC4)cc(-c4ccc(F)cc4)c3=O)c(F)c2)c2c(N)ncnc21 CHEMBL4877502 IC50 0.2 nM
Nc1ncnc2[nH]cc(-c3ccc(NC(=O)c4cn(CC5CCOCC5)cc(-c5ccc(F)cc5)c4=O)cc3)c12 CHEMBL4860162 IC50 0.2 nM
COc1cc2c(Oc3ccc(Nc4nn(C)cc4C(=O)NC4CCCCC4)cc3F)ccnc2cc1OCCCN1CCOCC1 CHEMBL5197792 Kd 0.26 nM
CC(C)n1cc(C(=O)Nc2ccc(-c3cn(C)c4ncnc(N)c34)cc2)c(=O)c(-c2ccc(F)cc2)c1 CHEMBL4875762 IC50 0.4 nM
Cn1cc(-c2ccc(NC(=O)c3cn(CC4CCOCC4)cc(-c4ccc(C(F)(F)F)cc4)c3=O)cc2)c2c(N)ncnc21 CHEMBL4873716 IC50 0.4 nM
Nc1ncnc2[nH]cc(-c3cc(F)c(NC(=O)c4cn(CC5CCOCC5)cc(-c5ccc(F)cc5)c4=O)cc3F)c12 CHEMBL4869472 IC50 0.4 nM
O=C1CC(c2ccc(O)c(O)c2O)Oc2ccccc21 CHEMBL5218452 IC50 0.49 nM
CN(C)C(=O)Cn1cc(C(=O)Nc2ccc(-c3cn(C)c4ncnc(N)c34)cc2)c(=O)c(-c2ccc(F)cc2)c1 CHEMBL4845677 IC50 0.5 nM
Cn1cc(-c2cc(F)c(NC(=O)c3cn(CC4CCOCC4)cc(-c4ccc(F)cc4)c3=O)cc2F)c2c(N)ncnc21 CHEMBL4873311 IC50 0.5 nM
CC(C)n1cc(C(=O)Nc2ccc(Oc3ccnc(NC(=O)CC4CCN(C)CC4)c3)cc2)c(=O)n(-c2ccc(F)cc2)c1=O CHEMBL4865592 IC50 0.65 nM
Nc1nc(Nc2ccc3c(c2)CC[C@@H](N2CCCC2)CC3)nn1-c1cc2c(nn1)-c1ccccc1CCC2 CHEMBL3809489 IC50 0.7 nM
CCc1nc(C(N)=O)c(Nc2ccc3c(c2)CCN(C2CCC(CC)C2)CC3)nc1NC1CCOCC1 CHEMBL4516515 IC50 0.7 nM
CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)c(OC)c2)nc1NC1CCOCC1 CHEMBL3301622 IC50 0.73 nM
CC(C)n1cc(C(=O)Nc2cc(F)c(Oc3ccnc(NC(=O)N4CCC(N5CCN(C)CC5)CC4)c3)cc2F)c(=O)n(-c2ccc(F)cc2)c1=O CHEMBL4852684 IC50 0.76 nM
O=C(Nc1ccc(Oc2ccnc3[nH]cnc23)c(F)c1)c1cccn(-c2ccc(F)cc2)c1=O CHEMBL4277499 IC50 0.77 nM
CC(C)n1cc(C(=O)Nc2ccc(Oc3ccnc(-c4cnn(C)c4)c3)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O CHEMBL4871310 IC50 0.8 nM
Cn1cc(-c2ccc(NC(=O)c3cn(CC4CCOCC4)cc(-c4ccc(F)cc4F)c3=O)cc2)c2c(N)ncnc21 CHEMBL4851553 IC50 0.8 nM
Cn1cc(-c2ccc(NC(=O)c3cn(CC4CCOCC4)cc(-c4ccc(F)cc4)c3=O)cc2F)c2c(N)ncnc21 CHEMBL4866647 IC50 0.8 nM
CC(C)n1cc(C(=O)Nc2ccc(Oc3ccnc(NC(=O)CC4CCN(C)CC4)c3)cc2F)c(=O)n(-c2ccc(F)cc2)c1=O CHEMBL4848604 IC50 0.81 nM
CC(C)n1cc(C(=O)Nc2ccc(Oc3cc(NC(=O)C4CC4)ncn3)cc2)c(=O)n(-c2ccc(F)cc2)c1=O CHEMBL4845957 IC50 0.85 nM
CC(C)n1cc(C(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O CHEMBL4873571 IC50 0.9 nM
CN(c1cccc2c1CN(c1nc(Nc3ccc(N4CCOCC4)cc3)ncc1C(F)(F)F)C2)S(C)(=O)=O CHEMBL4445940 IC50 0.94 nM
CS(=O)(=O)N1CCC[C@H](c2csc(-c3cc(N4CCNCC4)ccc3NC(=O)c3ncc[nH]3)n2)C1 CHEMBL4062894 IC50 1.0 nM
Cn1cc(-c2ccc(NC(=O)c3cn(CC4CCOCC4)cc(-c4ccccc4)c3=O)cc2)c2c(N)ncnc21 CHEMBL4871620 IC50 1.0 nM
CCOc1ccn(-c2ccc(F)cc2)c(=O)c1C(=O)Nc1ccc(Oc2ccnc(N)c2Cl)c(F)c1 CHEMBL460702 IC50 1.1 nM
COc1ccn(-c2ccc(F)cc2)c(=O)c1C(=O)Nc1ccc(Oc2ccnc(N)c2Cl)c(F)c1 CHEMBL4753082 IC50 1.1 nM
CN1CCC(CC(=O)Nc2cc(Oc3ccc(NC(=O)c4cn(C5CCCC5)c(=O)n(-c5ccc(F)cc5)c4=O)cc3F)ccn2)CC1 CHEMBL4867696 IC50 1.1 nM
Cn1cc(-c2ccc(NC(=O)c3cn(C4CCOCC4)cc(-c4ccc(F)cc4)c3=O)cc2)c2c(N)ncnc21 CHEMBL4855494 IC50 1.1 nM
CCc1nc(C(N)=O)c(Nc2ccc3c(c2)CCN(C2CCCC2)CC3)nc1NC1CCOCC1 CHEMBL4524568 IC50 1.2 nM
CCc1ccc2c(c1)c(=O)c(C(=O)Nc1ccc(Oc3ncnc4[nH]cc(-c5ccccc5)c34)c(F)c1)c(C)n2C CHEMBL4513513 Kd 1.2 nM
Cn1cc(-c2ccc(NC(=O)c3cn(CC4CCCO4)cc(-c4ccc(F)cc4)c3=O)cc2)c2c(N)ncnc21 CHEMBL4865357 IC50 1.2 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(C#CCNS(C)(=O)=O)cnc(N)c34)cc2)c1 CHEMBL1994321 pKi 1.259 nM
Nc1ncnc2scc(-c3ccc(NC(=O)Nc4cc(C(F)(F)F)ccc4F)cc3)c12 CHEMBL1998585 pKi 1.259 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(CC(C)O)c5)cnc(N)c34)cc2)c1 CHEMBL1989708 pKi 1.259 nM
CN1CCN(C2CCN(C(=O)Nc3cc(Oc4cc(F)c(NC(=O)c5cc6c(n(-c7ccccc7)c5=O)CCCC6=O)cc4F)ccn3)CC2)CC1 CHEMBL4849679 IC50 1.3 nM
N[C@H]1CC[C@H](Cn2nc(-c3ccc(N4CCNCC4)cc3)c3cnc(NCCCc4ccccc4)nc32)CC1 CHEMBL2036807 IC50 1.4 nM
COCCNCc1ccc(-c2cc3nccc(Oc4ccc(NC(=O)C5(C(=O)Nc6ccc(F)cc6)CC5)cc4F)c3s2)nc1 CHEMBL3989926 IC50 1.5 nM
CN1CCN(C2CCN(C(=O)Nc3cc(Oc4ccc(NC(=O)c5cn(C6CCCC6)c(=O)n(-c6ccc(F)cc6)c5=O)cc4)ncn3)CC2)CC1 CHEMBL4853815 IC50 1.5 nM
Nc1ncc(-c2cnn(CCO)c2)c2scc(-c3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12 CHEMBL1980297 pKi 1.585 nM
CCc1nc(C(N)=O)c(Nc2ccc3c(c2)CCC(N2CCCC2)CC3)nc1NC1CCOCC1 CHEMBL4576727 IC50 1.6 nM
CCCCNc1ncc2c(-c3ccc(CN4CCN(C)CC4)cc3)cn([C@H]3CC[C@H](O)CC3)c2n1 CHEMBL3326006 IC50 1.65 nM
CC(C)n1cc(C(=O)Nc2ccc(Oc3ccnc(NC(=O)N4CCCC4)c3)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O CHEMBL4861161 IC50 1.7 nM
CN(C)CCOc1ccc(NC(=O)c2ncc[nH]2)c(-c2nc([C@H]3CCCN(S(C)(=O)=O)C3)cs2)c1 CHEMBL4090103 IC50 1.8 nM
CCCn1cc(-c2ccc(NC(=O)c3cn(CC4CCOCC4)cc(-c4ccc(F)cc4)c3=O)cc2)c2c(N)ncnc21 CHEMBL4864971 IC50 1.8 nM
CC(C)n1cc(C(=O)Nc2ccc(Oc3ccnc(-c4cnn(C)c4)c3)cc2)c(=O)n(-c2ccc(F)cc2)c1=O CHEMBL4858048 IC50 1.9 nM
CN1CCC(CN2CCc3c(ncnc3Oc3ccc(NC(=O)c4cn(CC5CC5)c(=O)n(-c5ccc(F)cc5)c4=O)cc3F)C2)CC1 CHEMBL4858396 IC50 1.9 nM
CNC(=O)C(C)n1cc(-c2cnc(N)c3c(-c4ccc(NC(=O)Nc5ccc(C)cc5)cc4)csc23)cn1 CHEMBL1970142 pKi 1.995 nM
Cn1cc(-c2cnc(N)c3c(-c4ccc(NC(=O)Nc5ccc(OC(F)F)cc5)cc4)csc23)cn1 CHEMBL1988387 pKi 1.995 nM
Cc1ccc(C(=O)Nc2ccc(Oc3cc4cnn(C)c4cc3-c3cn[nH]c3)c(F)c2)c(=O)n1-c1ccc(F)cc1 CHEMBL3545307 IC50 2.0 nM
Cc1csc2c(-n3nc(Nc4ccc(OCCN5CCCC5)cc4)nc3N)nc(Cl)nc12 CHEMBL4105249 IC50 2.0 nM
CC(C)n1cc(C(=O)Nc2ccc(Oc3cc(NC(=O)N4CCC4)ncn3)cc2)c(=O)n(-c2ccc(F)cc2)c1=O CHEMBL4867664 IC50 2.0 nM
CC(C)n1cc(C(=O)Nc2ccc(Oc3cc(NC(=O)N4CCC(N5CCN(C)CC5)CC4)ncn3)cc2)c(=O)n(-c2ccc(F)cc2)c1=O CHEMBL4846932 IC50 2.0 nM
CC(C)n1cc(C(=O)Nc2ccc(Oc3cc(NC(=O)N4CCCC4)ncn3)cc2)c(=O)n(-c2ccc(F)cc2)c1=O CHEMBL4849099 IC50 2.1 nM
CS(=O)(=O)N1CCO[C@H](c2csc(-c3cc(N4CCOCC4)ccc3NC(=O)c3ncc[nH]3)n2)C1 CHEMBL4094158 IC50 2.2 nM
CN1CCC(CC(=O)Nc2cc(Oc3cc(F)c(NC(=O)c4cc5c(n(-c6ccccc6)c4=O)CCCC5=O)cc3F)ccn2)CC1 CHEMBL4864389 IC50 2.3 nM
Cn1cc(-c2ccc(NC(=O)c3cn(CC4CCCCC4)cc(-c4ccc(F)cc4)c3=O)cc2)c2c(N)ncnc21 CHEMBL4849955 IC50 2.3 nM
CN1CCC(CN2CCc3c(ncnc3Oc3ccc(NC(=O)c4cn(CC5CCC5)c(=O)n(-c5ccc(F)cc5)c4=O)cc3F)C2)CC1 CHEMBL4864780 IC50 2.4 nM
CCc1nc(C(N)=O)c(Nc2ccc3c(c2)CCC(N2CC4CNCC4C2)CC3)nc1NC1CCOCC1 CHEMBL4578043 IC50 2.5 nM
CN1CCC(CC(=O)Nc2cc(Oc3ccc(NC(=O)c4cn(C5CC5)c(=O)n(-c5ccc(F)cc5)c4=O)cc3F)ccn2)CC1 CHEMBL4865438 IC50 2.5 nM
Cc1ccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(C(C)C(=O)N(C)C)c5)cnc(N)c34)cc2)cc1 CHEMBL2001485 pKi 2.512 nM
CCc1ccc2c(c1)c(=O)c(C(=O)Nc1ccc(Oc3ncnc4cc(OC)c(OC)cc34)c(F)c1)c(C)n2C CHEMBL4571241 Kd 2.7 nM
CC(C)n1cc(C(=O)Nc2ccc(Oc3ncnc4c3CN(C(=O)C3CC3)C4)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O CHEMBL4878216 IC50 2.7 nM
CN1CCC(CN2CCc3c(ncnc3Oc3ccc(NC(=O)c4cn(C5CCCC5)c(=O)n(-c5ccc(F)cc5)c4=O)cc3F)C2)CC1 CHEMBL4860541 IC50 2.7 nM
Nc1ncnc2c1c(-c1ccc(NC(=O)c3cn(CC4CCOCC4)cc(-c4ccc(F)cc4)c3=O)cc1)cn2CCN1CCOCC1 CHEMBL4865839 IC50 2.7 nM
CC(C)n1cc(C(=O)Nc2cc(F)c(Oc3ccnc(-c4cnn(C)c4)c3)cc2F)c(=O)n(-c2ccc(F)cc2)c1=O CHEMBL4863290 IC50 2.75 nM
CN(C)CCn1cc(-c2ccc(NC(=O)c3cn(CC4CCOCC4)cc(-c4ccc(F)cc4)c3=O)cc2)c2c(N)ncnc21 CHEMBL4877967 IC50 2.8 nM
COc1cc2c(Oc3ccc(Nc4nn(C)cc4C(=O)NC4CCCCC4)cc3F)ccnc2cc1OCCCN1CCN(C)CC1 CHEMBL5184891 IC50 2.9 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL388978 IC50 3.0 nM
Nc1nc(Nc2ccc(OCCN3CCCC3)cc2)nn1-c1ncnc2ccc(Cl)cc12 CHEMBL4087395 IC50 3.0 nM
Nc1nc(Nc2ccc(OCCN3CCCC3)cc2)nn1-c1ncnc2ccc(F)cc12 CHEMBL4064955 IC50 3.0 nM
Nc1nc(Nc2ccc(N3CCN(C4CC5CCC4C5)CC3)cc2)nn1-c1ncnc2ccc(Cl)cc12 CHEMBL4090562 IC50 3.0 nM
Cn1cc(-c2ccc(NC(=O)c3cn(CC4CCOCC4)cc(-c4cccc(F)c4)c3=O)cc2)c2c(N)ncnc21 CHEMBL4853092 IC50 3.0 nM
CC(C)n1cc(C(=O)Nc2ccc(Oc3ccnc(-c4cn[nH]c4)c3)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O CHEMBL4869458 IC50 3.1 nM
COc1ccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(CCO)c5)cnc(N)c34)cc2)cc1 CHEMBL1977148 pKi 3.162 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(C#CCN5CCOCC5)cnc(N)c34)cc2)c1 CHEMBL1982465 pKi 3.162 nM
Cc1cc(C)cc(NC(=O)Nc2ccc3c(c2)CCc2sc4ncnc(N)c4c2-3)c1 CHEMBL1964687 pKi 3.162 nM
CCc1cccc(NC(=O)Nc2ccc3c(c2)CCc2sc4ncnc(N)c4c2-3)c1 CHEMBL1968406 pKi 3.162 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(C#CCN)cnc(N)c34)cc2)c1 CHEMBL1965988 pKi 3.162 nM
Cc1c(C(=O)Nc2ccc(Oc3ccnc4[nH]cc(-c5ccccc5)c34)c(F)c2)c(=O)n(-c2ccc(F)cc2)n1C CHEMBL3810063 pIC50 3.162 nM
COc1cc2c(Oc3ccc(Nc4nn(C)cc4C(=O)NC4CCCCC4)cc3F)ccnc2cc1OCCCN(C)C CHEMBL5193925 IC50 3.2 nM
CS(=O)(=O)N1CCC[C@H](c2csc(-c3cc(N4CCOCC4)ccc3NC(=O)c3ncc[nH]3)n2)C1 CHEMBL4066616 IC50 3.4 nM
COc1cc2nccc(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3)c2cc1OC CHEMBL2105717 IC50 3.4 nM
CC(C)n1cc(C(=O)Nc2ccc(Oc3ncnc4c3CN(C(=O)CC3CCN(C)CC3)C4)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O CHEMBL4865150 IC50 3.4 nM
CC(C)n1cc(C(=O)Nc2ccc(Oc3cc(NC(=O)N4CC(O)C4)ncn3)cc2)c(=O)n(-c2ccc(F)cc2)c1=O CHEMBL4864028 IC50 3.5 nM
CC(C)n1cc(C(=O)Nc2ccc(Oc3ncnc4c3CCN(C3CCN(CC5CC5)CC3)C4)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O CHEMBL4866147 IC50 3.5 nM
N[C@H]1CC[C@H](Cn2nc(-c3ccc(N4CCNCC4)nc3)c3cnc(NCCCc4ccccc4)nc32)CC1 CHEMBL2036805 IC50 3.7 nM
CC(C)n1cc(C(=O)Nc2cc(F)c(Oc3ccnc(-c4cnn(C)c4)c3)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O CHEMBL4864676 IC50 3.7 nM
CC(C)n1cc(C(=O)Nc2ccc(Oc3ncnc4c3CCN(CC3CCN(C)CC3)C4)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O CHEMBL4848465 IC50 3.7 nM
Cn1cc(-c2ccc(NC(=O)c3cn(CC4CCOCC4)cc(-c4ccc(F)cc4)c3=O)c(Cl)c2)c2c(N)ncnc21 CHEMBL4847126 IC50 3.7 nM
CC(C)n1cc(C(=O)Nc2ccc(Oc3ncnc4c3CCN(C3CN(C)C3)C4)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O CHEMBL4850929 IC50 3.8 nM
Cn1cc(-c2cnn3c(N)c(-c4ccc(NC(=O)Nc5cccc(C(F)(F)F)c5)cc4)cnc23)cn1 CHEMBL1988717 pKi 3.981 nM
CCN(CC)CC#Cc1cnc(N)c2c(-c3ccc(NC(=O)Nc4cccc(C)c4)cc3)csc12 CHEMBL2001257 pKi 3.981 nM
CNC(=O)c1sc(N2CC3CC2(CNC(=O)c2c[nH]c4ncc(C)cc24)C3)nc1C(F)(F)F CHEMBL4782810 pIC50 3.981 nM
CCCCNc1ncc2c(-c3ccc(N4CCNCC4)cc3)nn(C[C@H]3CC[C@H](N)CC3)c2n1 CHEMBL2036806 IC50 4.0 nM
Nc1nc(Nc2ccc(OCCN3CCCC3)cc2)nn1-c1ncnc2c1sc1ccccc12 CHEMBL4078564 IC50 4.0 nM
Cc1cc(-c2cn(C)c3ncnc(N)c23)ccc1NC(=O)c1cn(CC2CCOCC2)cc(-c2ccc(F)cc2)c1=O CHEMBL4856684 IC50 4.0 nM
CN1CCN(Cc2ccc(-c3cn4c5nc(ncc35)NCCCCCCCCNC(=O)[C@@H](N)CCCC4)cc2)CC1 CHEMBL3964573 IC50 4.2 nM
CN1CCC(CC(=O)Nc2cc(Oc3ccc(NC(=O)c4cc5c(n(-c6ccccc6)c4=O)CCCC5=O)c(F)c3)ccn2)CC1 CHEMBL4862542 IC50 4.2 nM
CC(C)n1cc(C(=O)Nc2ccc(Oc3ncnc4c3CCN(C(=O)CC3CCN(C)CC3)C4)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O CHEMBL4859147 IC50 4.3 nM
CN(c1cccc2c1CN(c1nc(Nc3ccc4c(c3)OCO4)ncc1C(F)(F)F)C2)S(C)(=O)=O CHEMBL4445646 IC50 4.5 nM
CCc1nc(C(N)=O)c(Nc2ccc3c(c2)CCN(C2CCN(C)CC2)CC3)nc1NC1CCOCC1 CHEMBL4519811 IC50 4.5 nM
Nc1nc(Nc2ccc3c(c2)CC[C@H](N2CCCC2)CC3)nn1-c1cc2c(nn1)-c1ccccc1CCC2 CHEMBL4857746 IC50 4.8 nM
CC(C)n1cc(C(=O)Nc2ccc(Oc3ccnc(-c4cnn(C)c4)c3)c(F)c2F)c(=O)n(-c2ccc(F)cc2)c1=O CHEMBL4846125 IC50 4.9 nM
Cc1c(C(=O)Nc2ccc(Oc3ccnc4cc(OCC(C)(C)O)ccc34)cc2)c(=O)n(-c2ccccc2)n1C CHEMBL3920222 IC50 5.0 nM
Cn1cc(C(=O)Nc2ccc(-c3cn(C)c4ncnc(N)c34)cc2)c(=O)c(-c2ccc(F)cc2)c1 CHEMBL4858746 IC50 5.0 nM
CC(=O)N1CCN(c2ccc(Nc3ncc(Cl)c(Nc4ccccc4-c4ncn(C(C)C)n4)n3)cc2)CC1 CHEMBL5184642 IC50 5.0 nM
CC(C)n1cnc(-c2ccccc2Nc2nc(Nc3ccc(N(C)C4CCN(C)CC4)cc3)ncc2Cl)n1 CHEMBL5185599 IC50 5.0 nM
CC(Oc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl CHEMBL1825138 pKi 5.012 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(C#CCN(C)C)cnc(N)c34)cc2)c1 CHEMBL1979883 pKi 5.012 nM
Cc1nc(N)c2c(-c3ccc(NC(=O)c4cn(CC5CCOCC5)cc(-c5ccc(F)cc5)c4=O)cc3)cn(C)c2n1 CHEMBL4846616 IC50 5.1 nM
Cc1ccc(-n2c(=O)c(C(=O)Nc3ccc(Oc4ncnc5c4CCN(CC4CCN(C)CC4)C5)c(F)c3)cn(C3CCCC3)c2=O)nc1 CHEMBL4860402 IC50 5.2 nM
CN(C)CC(=O)N1CCC(c2ccc(NC(=O)c3nc(C#N)c[nH]3)c(C3=CCCCC3)c2)CC1 CHEMBL1908395 Kd 5.3 nM
CC(C)n1cc(C(=O)Nc2ccc(Oc3ncnc4c3CCN(C(=O)C3CCC3)C4)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O CHEMBL4872556 IC50 5.3 nM
Cc1ccc(-n2c(=O)c(C(=O)Nc3ccc(Oc4ncnc5c4CCN(CC4CCN(C)CC4)C5)c(F)c3)cn(CC3CC3)c2=O)nc1 CHEMBL4857544 IC50 5.3 nM
CC(C)n1cc(C(=O)Nc2ccc(Oc3ccnc(-c4cnn(C)c4)c3)cc2F)c(=O)n(-c2ccc(F)cc2)c1=O CHEMBL4867669 IC50 5.5 nM
CC(C)Cn1cc(C(=O)Nc2ccc(Oc3ncnc4c3CCN(CC3CCN(C)CC3)C4)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O CHEMBL4870464 IC50 5.5 nM
CC(C)n1cc(C(=O)Nc2ccc(Oc3cc(NC(=O)N4CC(N5CCCC5)C4)ncn3)cc2)c(=O)n(-c2ccc(F)cc2)c1=O CHEMBL4861060 IC50 5.6 nM
CC(C)n1cc(C(=O)Nc2ccc(Oc3ncnc4c3CCN(C3CCN(C)CC3)C4)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O CHEMBL4856749 IC50 5.6 nM
COc1cc2c(Oc3ccc(Nc4nn(C)cc4C(=O)NC4CCCCC4)cc3F)ccnc2cc1OCCCN1CCCCC1 CHEMBL5208952 IC50 5.6 nM
CCC(=O)Nc1cc(Oc2ccc(NC(=O)c3cn(C(C)C)c(=O)n(-c4ccc(F)cc4)c3=O)cc2F)ccn1 CHEMBL4855681 IC50 5.8 nM
N#Cc1cnc(C(=O)Nc2ccc(C3CCN(CCN4CCOCC4)CC3)cc2C2=CCCCC2)[nH]1 CHEMBL2158230 IC50 6.0 nM
COc1cc2c(Oc3ccc(NS(=O)(=O)c4c(F)cccc4F)cc3F)ccnc2cc1OCCCN1CCN(C)CC1 CHEMBL4462318 Kd(free) 6.0 nM
CC(C)n1cc(C(=O)Nc2ccc(Oc3ncnc4c3CN(C(=O)CN3CCN(C)CC3)C4)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O CHEMBL4875387 IC50 6.0 nM
CC(C)n1cc(C(=O)Nc2ccc(Oc3ncnc4c3CN(CC3CCN(C)CC3)C4)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O CHEMBL4878071 IC50 6.2 nM
CC(C)n1cc(C(=O)Nc2ccc(Oc3ncnc4c3CCN(CC3CN(C)C3)C4)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O CHEMBL4859513 IC50 6.3 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(C#CCN5CCCC5)cnc(N)c34)cc2)c1 CHEMBL1973211 pKi 6.31 nM
COc1ccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(CC(C)(C)O)c5)cnc(N)c34)cc2)cc1 CHEMBL2004290 pKi 6.31 nM
Cc1ccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(C)c5)cnc(N)c34)cc2)cc1 CHEMBL1982466 pKi 6.31 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4ncnc(N)c34)cc2)c1 CHEMBL196363 pKi 6.31 nM
CC1CCN(c2cc(N3CCN(C)CC3)ccc2NC(=O)c2cc(C#N)c[nH]2)CC1 CHEMBL254702 IC50 6.4 nM
CNC1CN(C(=O)Nc2cc(Oc3ccc(NC(=O)c4cn(C(C)C)c(=O)n(-c5ccc(F)cc5)c4=O)cc3)ncn2)C1 CHEMBL4868163 IC50 6.4 nM
CC(C)n1cc(C(=O)Nc2ccc(Oc3ncnc4c3CCN(C)C4)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O CHEMBL4870149 IC50 6.6 nM
CC(=O)Nc1cc(Oc2ccc(NC(=O)c3cn(C(C)C)c(=O)n(-c4ccc(F)cc4)c3=O)cc2F)ccn1 CHEMBL4856526 IC50 6.7 nM
CN1CCC(CC(=O)Nc2cc(Oc3ccc(NC(=O)c4cc5c(n(-c6ccccc6)c4=O)CCCC5=O)cc3)ccn2)CC1 CHEMBL4867578 IC50 6.8 nM
CN1CCC(CC(=O)Nc2cc(Oc3ccc(NC(=O)c4cc5c(n(-c6ccccc6)c4=O)CCCC5=O)cc3F)ccn2)CC1 CHEMBL4869320 IC50 6.9 nM
COc1cc2nccc(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3F)c2cc1OC CHEMBL489326 IC50 7.0 nM
O=C1Nc2ccc(CN3C(=O)CSC3=O)cc2/C1=C/c1cc(CN2CCOCC2)c[nH]1 CHEMBL3808948 IC50 7.0 nM
Nc1nc(Nc2ccc(OCCN3CCCC3)cc2)nn1-c1nc(Cl)nc2ccccc12 CHEMBL4102842 IC50 7.0 nM
CN1CCN(C2CCN(C(=O)Nc3cc(Oc4ccc(NC(=O)c5cn(C6CC6)c(=O)n(-c6ccc(F)cc6)c5=O)cc4)ncn3)CC2)CC1 CHEMBL4873739 IC50 7.1 nM
C[C@@H](Oc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl CHEMBL601719 Kd 7.8 nM
CC(C)n1cc(C(=O)Nc2ccc(Oc3ncnc4c3CCN(C(=O)CCN3CCCC3)C4)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O CHEMBL4858522 IC50 7.8 nM
COCCOc1cc2nccc(Oc3ccc(Nc4nn(C)cc4C(=O)NC4CCCCC4)cc3F)c2cc1OC CHEMBL5206835 IC50 7.8 nM
N#CCOc1ccc(Nc2nc(Nc3cccc(S(N)(=O)=O)c3)ncc2Br)cc1 CHEMBL1987034 pKi 7.943 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(C#CC(C)(C)N)cnc(N)c34)cc2)c1 CHEMBL1979577 pKi 7.943 nM
Nc1ncnc2c1N=C(c1ccc(NC(=O)Nc3cc(C(F)(F)F)ccc3F)cc1)CCN2 CHEMBL411903 pKi 7.943 nM
COCCOC1CCC(n2nc(-c3ccc(Nc4nc5cc(C)cc(C)c5o4)cc3)c3c(N)ncnc32)CC1 CHEMBL1984162 pKi 7.943 nM
CC(C)n1cc(C(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CCC4)c3)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O CHEMBL4856234 IC50 8.0 nM
Cc1nc(-c2ccccc2Nc2nc(Nc3ccc(C(=O)N4CCN(C)CC4)cc3)ncc2Cl)nn1C CHEMBL5187900 IC50 8.0 nM
Cn1cc(-c2ccc(F)cc2)c(=O)c2c(Nc3ccc(Oc4ccnc(NC(=O)C5CC5)c4)c(F)c3)nccc21 CHEMBL4584949 IC50 8.2 nM
CCc1nc(C(N)=O)c(Nc2ccc3c(c2)CCN(C2CC2)CC3)nc1NC1CCOCC1 CHEMBL4581972 IC50 8.3 nM
CN1CCC(CN2CCc3c(ncnc3Oc3ccc(NC(=O)c4cn(CCF)c(=O)n(-c5ccc(F)cc5)c4=O)cc3F)C2)CC1 CHEMBL4874534 IC50 8.5 nM
CC(C)n1cc(C(=O)Nc2ccc(Oc3ccnc(NC(=O)N4CCOCC4)c3)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O CHEMBL4875798 IC50 8.6 nM
CC(C)n1cc(C(=O)Nc2ccc(Oc3ncnc4c3CN(CC3CCOCC3)C4)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O CHEMBL4861291 IC50 8.6 nM
COCCCOc1cc2nccc(Oc3ccc(Nc4nn(C)cc4C(=O)NC4CCCCC4)cc3F)c2cc1OC CHEMBL5198669 IC50 8.6 nM
CC(C)n1cc(C(=O)Nc2ccc(Oc3ccncc3-c3cnn(C)c3)cc2)c(=O)n(-c2ccc(F)cc2)c1=O CHEMBL4875876 IC50 8.7 nM
CCn1cc(C(=O)Nc2ccc(Oc3ccncc3-c3cnn(C)c3)cc2)c(=O)n(-c2ccc(F)cc2)c1=O CHEMBL4851321 IC50 8.8 nM
CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C CHEMBL535 Kd 9.0 nM
COc1cc2ncnc(-n3nc(Nc4ccc(N5CCN(C6CC7CCC6C7)CC5)c(Cl)c4)nc3N)c2cc1OC CHEMBL4059790 IC50 9.0 nM
Cc1csc2c(-n3nc(Nc4ccc(N5CCN(C6CC7CCC6C7)CC5)cc4)nc3N)nc(Cl)nc12 CHEMBL4068447 IC50 9.0 nM
Cc1nc(-c2ccccc2Nc2nc(Nc3ccc(C(=O)N4CCN(C)CC4)cc3)ncc2Cl)n[nH]1 CHEMBL5201640 IC50 9.0 nM
CN1CCN(Cc2ccc(-c3cn4c5nc(ncc35)NCCCCCCCCC(O)CCCC4)cc2)CC1 CHEMBL3967759 IC50 9.3 nM
CC(C)n1cc(C(=O)Nc2ccc(Oc3ncnc4c3CCN(CC(=O)N3CCN(C)CC3)C4)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O CHEMBL4846790 IC50 9.5 nM
COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 CHEMBL509032 pKi 10.0 nM
Cc1ccc(F)c(NC(=O)Nc2ccc(-c3cncc4c3c(N)nn4C)cc2)c1 CHEMBL402846 pKi 10.0 nM
NC(COc1cncc(-c2ccc3c(c2)C(=Cc2ccco2)C(=O)N3)c1)Cc1c[nH]c2ccccc12 CHEMBL2001751 pKi 10.0 nM
CCNC(=O)c1cnc(N)c2c(-c3ccc(NC(=O)Nc4cccc(F)c4)cc3)csc12 CHEMBL1979516 pKi 10.0 nM
Nc1nc(Nc2ccc(N3CCN(C4CC5CCC4C5)CC3)cc2)nn1-c1ncnc2ccc(F)cc12 CHEMBL4095789 IC50 10.0 nM
COc1cc2c(Oc3ccc(NC(=O)C4(c5nnc(-c6ccc(F)cc6)o5)CC4)cc3F)ccnc2cc1OCCCN1CCCCC1 CHEMBL4764463 IC50 10.0 nM
COc1cc2c(Nc3cnc(OCCCC4CCCC4)nc3)ncnc2cc1OCCCN1CCCCC1 CHEMBL4777640 pIC50 10.0 nM
CNC(=O)c1sc(N2CC3CC2(CNC(=O)c2c[nH]c4ncc(Cl)cc24)C3)nc1C(F)(F)F CHEMBL4744243 pIC50 10.0 nM
CNC(=O)c1sc(N2CC3CC2(CNC(=O)c2c[nH]c4ncccc24)C3)nc1C(F)(F)F CHEMBL4740965 pIC50 10.0 nM
Cc1nc(-c2ccccc2Nc2nc(Nc3ccc(OC4CCN(C)CC4)cc3)ncc2Cl)n[nH]1 CHEMBL5171253 IC50 10.0 nM
Cc1nc(-c2ccccc2Nc2nc(Nc3ccc(OC4CCN(C)CC4)cc3)ncc2Cl)nn1C CHEMBL5192037 IC50 10.0 nM
CCc1nc(C(N)=O)c(Nc2ccc3c(c2)CCN(C(=O)C2(N)CC2)CC3)nc1NC1CCOCC1 CHEMBL4529955 IC50 10.3 nM
CC(C)n1cc(C(=O)Nc2ccc(Oc3ccnc(-c4cnn(C5CC5)c4)c3)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O CHEMBL4846678 IC50 10.5 nM
CN1CCN(Cc2ccc(-c3cn4c5nc(ncc35)NCCCCCCNC(=O)[C@@H](N)CCCC4)cc2)CC1 CHEMBL3892515 IC50 11.0 nM
Cc1c(C(=O)Nc2ccc(Oc3ccnc4cc(OCC(C)(C)O)ccc34)c(F)c2)c(=O)n(-c2ccccc2)n1C CHEMBL3984441 IC50 11.0 nM
COc1cc2ncnc(Oc3ccc(Nc4nccc5[nH]cc(-c6ccc(F)cc6)c(=O)c45)cc3F)c2cc1OC CHEMBL4794496 IC50 11.0 nM
CC(C)n1cc(C(=O)Nc2ccc(Oc3ccnc(NC(=O)CN(C)C)c3)cc2)c(=O)n(-c2ccc(F)cc2)c1=O CHEMBL4873958 IC50 11.0 nM
Cc1nc(-c2ccccc2Nc2nc(Nc3ccc(CN4CCN(C)CC4)cc3)ncc2Cl)n[nH]1 CHEMBL5169760 IC50 11.0 nM
CCn1nc(-c2ccccc2Nc2nc(Nc3ccc(N4CCN(C(C)=O)CC4)cc3)ncc2Cl)nc1C CHEMBL5187688 IC50 11.0 nM
COc1cc2nccc(Oc3ccc(Nc4nn(C)cc4C(=O)NC4CCCCC4)cc3F)c2cc1OC CHEMBL5174389 IC50 11.4 nM
COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(N(C)C(=O)CN2CCN(C)CC2)cc1)c1ccccc1 CHEMBL502835 Kd 12.0 nM
CCCCNc1ncc2c(-c3ccc(N4CCNCC4)nc3)nn(C[C@H]3CC[C@H](N)CC3)c2n1 CHEMBL2036804 IC50 12.0 nM
CN(C)CC(=O)N1CCC(c2ccc(NC(=O)c3nc(C#N)c[nH]3)c(C3=CCCCC3)c2)CC1 CHEMBL1908842 IC50 12.0 nM
CC(C)n1cc(C(=O)Nc2ccc(Oc3ncnc4c3CCN(C(=O)C3CCN(C)CC3)C4)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O CHEMBL4846861 IC50 12.0 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccc4ncccc4c3)cc2)n(-c2ccc3ncccc3c2)n1 CHEMBL5177673 IC50 12.0 nM
Cc1nc(-c2ccccc2Nc2nc(Nc3ccc(C(=O)N4CC5CC4CN5C)cc3)ncc2Cl)n[nH]1 CHEMBL5180366 IC50 12.0 nM
Cc1nc(-c2ccccc2Nc2nc(Nc3ccc(OC4CCN(C)CC4)c(F)c3)ncc2Cl)n[nH]1 CHEMBL5204838 IC50 12.0 nM
CN1CCC(Oc2ccc(Nc3ncc(Cl)c(Nc4ccccc4-c4nnn(C)n4)n3)cc2)CC1 CHEMBL5197492 IC50 12.0 nM
CCC[C@H](C)Nc1ncc2c(-c3ccc(CN4CCCN(C)CC4)cc3)cn([C@H]3CC[C@H](O)CC3)c2n1 CHEMBL4283353 IC50 12.1 nM
COc1cc2nccc(Oc3ccc(Nc4nn(C)cc4C(=O)NC4CCCCCCC4)cc3F)c2cc1OC CHEMBL5188331 IC50 12.5 nM
Cc1cnc(Nc2cccc(S(N)(=O)=O)c2)nc1Nc1ccc(OCC(N)=O)cc1 CHEMBL1988838 pKi 12.59 nM
Nc1nccc2scc(-c3ccc(NC(=O)Nc4cccc(Br)c4)cc3)c12 CHEMBL1976220 pKi 12.59 nM
Cc1cccc(NC(=O)Nc2ccc(-c3cncc4c3c(N)nn4C)cc2)c1 CHEMBL404367 pKi 12.59 nM
CNc1ncc2c(-c3ccc(N4CCN(C)CC4)cc3)nn(CC3CCCC3)c2n1 CHEMBL4218175 IC50 13.0 nM
Cn1cc(-c2cnccc2Oc2ccc(NC(=O)c3c[nH]c(=O)n(-c4ccc(F)cc4)c3=O)cc2)cn1 CHEMBL4856142 IC50 13.0 nM
COc1cc2nccc(Oc3ccc(Nc4nn(C)cc4C(=O)NC4C5CC6CC(C5)CC4C6)cc3F)c2cc1OC CHEMBL5184070 IC50 13.2 nM
Nc1nc(Nc2ccc3c(c2)CCC(N2CCCC2)CC3)nn1-c1cc2c(nn1)-c1ccccc1CCC2 CHEMBL2023349 IC50 14.0 nM
CN1CCN(Cc2ccc(-c3cn4c5nc(ncc35)NCCCCCCCC(O)CCC4)cc2)CC1 CHEMBL3910520 IC50 14.0 nM
Nc1nc(Nc2ccc(OCCN3CCCC3)cc2)nn1-c1ncnc2c1CCC2 CHEMBL4086420 IC50 14.0 nM
CNc1ncc2c(-c3ccc(N4CCNCC4)cc3)nn(CC3CCC(N)CC3)c2n1 CHEMBL2036792 IC50 14.0 nM
CC(C)n1cc(C(=O)Nc2ccc(Oc3ncnc4c3CCN(CC(=O)N3CCC3)C4)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O CHEMBL4851171 IC50 14.0 nM
CN1CCc2ccc(Nc3ncc(Cl)c(Nc4ccccc4S(=O)(=O)N(C)C)n3)cc2C1 CHEMBL5189859 IC50 14.0 nM
Cc1nc(-c2ccccc2Nc2nc(Nc3ccc4c(c3)CN(C)CC4)ncc2Cl)n[nH]1 CHEMBL5186349 IC50 14.0 nM
Nc1nc(Nc2ccc3c(c2)CC[C@@H](N2CCCC2)CC3)nn1-c1cc2c(nn1)CCCc1ccccc1-2 CHEMBL5175652 IC50 14.0 nM
CN1CCN(Cc2ccc(-c3cn([C@H]4CC[C@H](O)CC4)c4nc(NCCC5CC5)ncc34)cc2)CC1 CHEMBL3326007 IC50 15.0 nM
Nc1nc(Nc2ccc(N3CCN(C4CC5CCC4C5)CC3)cc2)nn1-c1nccc2ccccc12 CHEMBL4101639 IC50 15.0 nM
CCCCNc1ncc2c(-c3ccc(C4(N5CCN(C)CC5)CC4)cc3)cn([C@H]3CC[C@H](O)CC3)c2n1 CHEMBL4284541 IC50 15.0 nM
COc1cc2c(Oc3ccc(NS(=O)(=O)c4cc(F)ccc4F)cc3F)ccnc2cc1OCCCN1CCN(C)CC1 CHEMBL4443828 Kd(free) 15.0 nM
CC(C)n1cc(C(=O)Nc2ccc(Oc3ncnc4c3CN(C(=O)CCN3CCCC3)C4)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O CHEMBL4860139 IC50 15.0 nM
Cc1nc(-c2ccccc2Nc2nc(Nc3ccc(C(=O)N4CC5CN(C)CC5C4)cc3)ncc2Cl)n[nH]1 CHEMBL5209264 IC50 15.0 nM
Cc1nc(-c2ccccc2Nc2nc(Nc3ccc(N(C)C4CCN(C)CC4)cc3)ncc2Cl)n[nH]1 CHEMBL5209500 IC50 15.0 nM
CN1CCN(Cc2ccc(Nc3ncc(Cl)c(Nc4ccccc4S(=O)(=O)N(C)C)n3)cc2)CC1 CHEMBL2022968 IC50 15.0 nM
CCC(N)(C#Cc1cnc(N)c2c(-c3ccc(NC(=O)Nc4cccc(C)c4)cc3)csc12)CC CHEMBL1983025 pKi 15.85 nM
CCOc1ccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(C)c5)cnc(N)c34)cc2)cc1 CHEMBL1974254 pKi 15.85 nM
Cc1cc(C)cc(NC(=O)Nc2ccc(-c3cccc4c3CNC4=O)c(C)c2)c1 CHEMBL2004311 pKi 15.85 nM
Cc1cccc(NC(=O)Nc2ccc3c(c2)CCc2sc4ncnc(N)c4c2-3)c1 CHEMBL1242373 pKi 15.85 nM
CCN(CC)CCNC(=O)c1c(C)[nH]c(C=C2C(=O)Nc3ccc(F)cc32)c1C CHEMBL1990885 pKi 15.85 nM
COc1ccc(-c2ccc(NC(=O)Nc3cccc(Br)c3)cc2)c2c(N)noc12 CHEMBL271381 pKi 15.85 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4ccnc(N)c34)cc2)c1 CHEMBL394619 pKi 15.85 nM
Cc1cc(C)cc(NC(=O)Nc2ccc(-c3cccc4c3CNC4=O)c(C(F)(F)F)c2)c1 CHEMBL1971021 pKi 15.85 nM
Cc1cccc(NC(=O)Nc2ccc(-c3coc4ncnc(N)c34)cc2)c1 CHEMBL1983963 pKi 15.85 nM
CC(C)(C(N)=O)n1cc(-c2cnc(N)c3c(-c4ccc(NC(=O)Nc5cccc(F)c5)cc4)csc23)cn1 CHEMBL1967720 pKi 15.85 nM
CNC(=O)C[C@@H](NC(=O)[C@@H](CCc1ccccc1)NC(=O)c1c(C)noc1-c1snnc1C)c1ccc(C(F)(F)F)cc1 CHEMBL4746146 pIC50 15.85 nM
COc1cc2c(Oc3cc(NS(=O)(=O)c4cc(F)ccc4F)ccc3F)ccnc2cc1OCCCN1CCC(C)CC1 CHEMBL2023351 IC50 16.0 nM
N[C@H]1CC[C@H](Cn2nc(-c3ccc(F)cc3)c3cnc(NCCCc4ccccc4)nc32)CC1 CHEMBL2036809 IC50 16.0 nM
CS(=O)(=O)CCN1CCC(c2ccc(NC(=O)c3nc(C#N)c[nH]3)c(C3=CCCCC3)c2)CC1 CHEMBL2158227 IC50 16.0 nM
COc1cc2ncnc(-n3nc(Nc4ccc(C5CCN(C)CC5)cc4)nc3N)c2cc1OC CHEMBL4090507 EC50 16.0 nM
COc1cc2ncnc(-n3nc(Nc4ccc(OCCN5CCCC5)c(Cl)c4)nc3N)c2cc1OC CHEMBL4081956 IC50 16.0 nM
COc1cc2c(Oc3ccc(NS(=O)(=O)c4cc(F)ccc4F)cc3F)ccnc2cc1OCCCN1CCC(C)CC1 CHEMBL4589698 IC50 16.0 nM
CC(C)n1cc(C(=O)Nc2ccc(Oc3ncnc4c3CN(C(=O)CN3CCOCC3)C4)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O CHEMBL4860065 IC50 16.0 nM
CC(=O)N1CCN(c2ccc(Nc3ncc(Cl)c(Nc4ccccc4-c4n[nH]c(C)n4)n3)cc2)CC1 CHEMBL5178768 IC50 16.0 nM
CC(=O)N1CCN(c2ccc(Nc3ncc(Cl)c(Nc4ccccc4-c4nc(C)n(C)n4)n3)cc2)CC1 CHEMBL5199302 IC50 16.0 nM
CNC(=O)C[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)c1c(C)noc1-c1snnc1C)c1ccc(C(F)(F)F)cc1 CHEMBL5405985 IC50 16.0 nM
Cn1cc(-c2cnccc2Oc2ccc(NC(=O)c3cc4c(n(-c5ccc(F)cc5)c3=O)CCCC4=O)cc2)cn1 CHEMBL4853182 IC50 16.8 nM
CN1CCN(Cc2ccc(-c3cn4c5nc(ncc35)NCCCCCCCCC(O)CCCCC4)cc2)CC1 CHEMBL3984314 IC50 17.0 nM
CN1CCN(Cc2ccc(-c3cn4c5nc(ncc35)NCCCCCCCC(O)CCCC4)cc2)CC1 CHEMBL3932614 IC50 17.0 nM
COc1cc2c(Oc3ccc(NC(=O)c4c(C)n(C)n(-c5ccccc5)c4=O)cc3F)ccnc2cc1OCC(C)(C)O CHEMBL3919169 IC50 17.0 nM
CC(C)n1cc(C(=O)Nc2ccc(Oc3ncnc4c3CCN(C(=O)CN3CCOCC3)C4)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O CHEMBL4875172 IC50 17.0 nM
CN1CC2CN(C(=O)c3ccc(Nc4ncc(Cl)c(Nc5ccccc5S(=O)(=O)N(C)C)n4)cc3)CC2C1 CHEMBL5173201 IC50 17.0 nM
CC(C)n1cc(C(=O)Nc2ccc(Oc3ccnc(-c4cnn(CC(C)(C)O)c4)c3)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O CHEMBL4848473 IC50 17.4 nM
CN1CCN(Cc2ccc(-c3cn4c5nc(ncc35)NCCCCCCCC(O)CCCCC4)cc2)CC1 CHEMBL3946971 IC50 18.0 nM
COc1cc2c(Oc3ccc(NS(=O)(=O)c4ccccc4C(F)(F)F)cc3F)ccnc2cc1OCCCN1CCCCC1 CHEMBL4439964 IC50 18.0 nM
CCn1nc(-c2ccccc2Nc2nc(Nc3ccc(OC4CCN(C)CC4)cc3)ncc2Cl)nc1C CHEMBL5203409 IC50 18.0 nM
CN1CCN(Cc2ccc(Nc3ncc(Cl)c(Nc4ccccc4S(=O)(=O)N4CCCC4)n3)cc2)CC1 CHEMBL2022975 IC50 19.0 nM
CCOc1cn(-c2ccc(F)cc2C)nc1C(=O)Nc1ccc(Oc2ccnc3cc(OC)c(OC)cc23)c(F)c1 CHEMBL3808844 IC50 19.0 nM
COc1cc2c(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3F)ccnc2cc1OCCCC(=O)NO CHEMBL3981567 IC50 19.0 nM
Cc1ccc(NC(=O)Nc2ccc(-c3csc4ncnc(N)c34)cc2)cc1C CHEMBL2000335 pKi 19.95 nM
CCCn1cc(-c2cnc(N)c3c(-c4ccc(NC(=O)Nc5cccc(F)c5)cc4)csc23)cn1 CHEMBL1993941 pKi 19.95 nM
Cc1cc(N2CCOCC2)cc2[nH]c(-c3c(NCC(O)c4cccc(Cl)c4)cc[nH]c3=O)nc12 CHEMBL2005886 pKi 19.95 nM
O=C1Nc2ccc3ncsc3c2C1=CNc1ccc(S(=O)(=O)Nc2ccccn2)cc1 CHEMBL1973540 pKi 19.95 nM
CC(O)Cn1cc(-c2cnc(N)c3c(-c4ccc(NC(=O)Nc5cccc(F)c5)cc4)csc23)cn1 CHEMBL2002165 pKi 19.95 nM
Cc1cc(C)cc(NC(=O)Nc2ccc(-c3c(C)sc4ncnc(N)c34)cc2)c1 CHEMBL371206 pKi 19.95 nM
Nc1nc(Nc2ccc(N3CCN(C4CC5CCC4C5)CC3)c(F)c2)nn1-c1ncnc2ccsc12 CHEMBL4062594 EC50 20.0 nM
Cc1ncc(C(=O)Nc2ccc(Oc3ccncc3-c3cnn(C)c3)cc2)c(=O)n1-c1ccc(F)cc1 CHEMBL4861226 IC50 20.5 nM
Nc1nc(Nc2ccc(N3CCN(C4CC5CCC4C5)CC3)cc2)nn1-c1ncnc2ccsc12 CHEMBL4098293 EC50 21.0 nM
COc1cc2c(Oc3ccc(NS(=O)(=O)c4ccccc4C(F)(F)F)cc3F)ccnc2cc1OCCCN1CCN(C)CC1 CHEMBL4587811 IC50 21.0 nM
COc1cc2c(Oc3ccc(NS(=O)(=O)c4ccccc4C(F)(F)F)cc3F)ccnc2cc1OCCCN1CCOCC1 CHEMBL4536115 IC50 21.0 nM
COc1cc2c(Oc3ccc(NS(=O)(=O)c4ccccc4C(F)(F)F)cc3F)ccnc2cc1OCCCCN1CCOCC1 CHEMBL4440766 IC50 21.0 nM
COc1cc2c(Oc3ccc(NS(=O)(=O)c4ccccc4C(F)(F)F)cc3F)ccnc2cc1OCCCN1CCC(C)CC1 CHEMBL4447225 IC50 21.0 nM
COc1cc2c(Oc3ccc(NS(=O)(=O)c4cc(F)ccc4F)cc3F)ccnc2cc1OCCCN1CCCC(C)C1 CHEMBL4457733 IC50 21.0 nM
CC(C)n1cc(C(=O)Nc2ccc(Oc3ccnc(-c4cnn(C)c4)c3)c(Cl)c2)c(=O)n(-c2ccc(F)cc2)c1=O CHEMBL4864426 IC50 21.9 nM
CCCCNc1ncc2c(-c3ccc(S(=O)(=O)N4CCN(C)CC4)c(F)c3)cn([C@H]3CC[C@H](O)CC3)c2n1 CHEMBL3326004 IC50 22.0 nM
CC(C)n1cc(C(=O)Nc2ccc(Oc3ncnc4c3CN(C)C4)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O CHEMBL4872079 IC50 22.0 nM
CC(=O)N1CCN(c2ccc(Nc3ncc(Cl)c(Nc4ccccc4-c4ncn(C)n4)n3)cc2)CC1 CHEMBL5205244 IC50 22.0 nM
CN1CCC(N(C)c2ccc(Nc3ncc(Cl)c(Nc4ccccc4-c4ncn(C)n4)n3)cc2)CC1 CHEMBL5179008 IC50 22.0 nM
CC(=O)N1CCN(c2ccc(Nc3ncc(Cl)c(Nc4ccccc4-c4nnnn4C)n3)cc2)CC1 CHEMBL5177979 IC50 23.0 nM
COc1cc2nccc(Oc3ccc(Nc4nn(C)cc4C(=O)Nc4ccc(C)cc4)cc3F)c2cc1OC CHEMBL5189364 IC50 23.1 nM
CC[C@@H]1C[C@H]1Nc1ncc2c(C3CCN(C(=O)c4cc(C)nc(C)c4)CC3)cn([C@H]3CC[C@H](O)CC3)c2n1 CHEMBL4856976 IC50 24.0 nM
CN1CCN(Cc2ccc(-c3cn4c5nc(ncc35)NCCCCCCC(O)CCCCC4)cc2)CC1 CHEMBL3976261 IC50 25.0 nM
CS(=O)(=O)N1CCO[C@H](c2csc(-c3ccccc3NC(=O)c3ncc[nH]3)n2)C1 CHEMBL4086393 IC50 25.0 nM
CN1CCC(Oc2ccc(Nc3ncc(Cl)c(Nc4ccccc4-c4nnnn4C)n3)cc2)CC1 CHEMBL5187223 IC50 25.0 nM
Cc1cc(Nc2ncc(F)c(NC3C4C=CC(C4)C3C(N)=O)n2)ccc1N1CCN(C)CC1 CHEMBL1967878 pKi 25.12 nM
Cc1cccc(NC(=O)Nc2ccc(-c3cnc4c(-c5cnn(C)c5)cnn4c3N)cc2)c1 CHEMBL508928 pKi 25.12 nM
CNC(=O)c1sc(N2CC3CC2(CNC(=O)c2c[nH]c4ncc(C(F)(F)F)cc24)C3)nc1C(F)(F)F CHEMBL4747462 pIC50 25.12 nM
COc1cc2nccc(Oc3ccc(Nc4nn(C)cc4C(=O)Nc4ccccc4)cc3F)c2cc1OC CHEMBL5206823 IC50 25.4 nM
Cc1nn(C)cc1-c1cc(Oc2ccc(NC(=O)c3cn(C(C)C)c(=O)n(-c4ccc(F)cc4)c3=O)cc2F)ccn1 CHEMBL4863687 IC50 25.6 nM
CN1CCN(Cc2ccc(-c3cn4c5nc(ncc35)NCCCCCCCCC(O)CCC4)cc2)CC1 CHEMBL3948030 IC50 26.0 nM
CCCCNc1ncc2c(-c3ccc(N4CCN(C)CC4)cc3)cn([C@H]3CC[C@H](O)CC3)c2n1 CHEMBL4283152 IC50 26.0 nM
Cc1c(C(=O)Nc2ccc(Oc3ncnc4[nH]cc(-c5ccccc5)c34)c(F)c2)c(=O)c2cc(C(C)C)ccc2n1C CHEMBL4449888 IC50 26.0 nM
CC(C)n1cc(C(=O)Nc2ccc(Oc3ccnc(-c4cnn(CCN5CCN(C)CC5)c4)c3)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O CHEMBL4872759 IC50 26.0 nM
CC(C)n1cc(C(=O)Nc2ccc(Oc3ncnc4c3CC(=O)N4)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O CHEMBL4852474 IC50 26.0 nM
CCC[C@H](C)Nc1ncc2c(C3CCN(C(=O)c4cc(C)nc(C)c4)CC3)cn([C@H]3CC[C@H](O)CC3)c2n1 CHEMBL4877347 IC50 26.1 nM
CC(C)[S+]([O-])c1ccccc1Nc1nc(Nc2ccc(CN3CCN(C)CC3)cc2)ncc1Cl CHEMBL2347987 IC50 27.0 nM
COc1cc2c(Oc3ccc(NS(=O)(=O)c4ccccc4C(F)(F)F)cc3F)ccnc2cc1OCCCN(C)C CHEMBL4439173 IC50 27.0 nM
COc1cc2c(Oc3ccc(NS(=O)(=O)c4cc(F)ccc4F)cc3F)ccnc2cc1OCCCCN1CCOCC1 CHEMBL4563652 IC50 27.0 nM
COc1cc2c(Oc3ccc(NS(=O)(=O)c4ccccc4OC(F)(F)F)cc3F)ccnc2cc1OCCCN1CCN(C)CC1 CHEMBL4470236 IC50 27.0 nM
CCN1CCN(CCCOc2cc3nccc(Oc4c(F)cc(NC(=O)NN5C(=O)CSC5c5ccc(F)cc5F)cc4F)c3cc2OC)CC1 CHEMBL5409449 IC50 27.0 nM
COc1cc2nccc(Oc3ccc(Nc4nn(C)cc4C(=O)NC4CCCC4)cc3F)c2cc1OC CHEMBL5182518 IC50 27.4 nM
CN1CCN(Cc2ccc(-c3cn4c5nc(ncc35)NCCCCCC(O)CCCCC4)cc2)CC1 CHEMBL3938180 IC50 28.0 nM
CC(=O)N1CCc2ccc(Nc3ncc(Cl)c(Nc4ccccc4-c4n[nH]c(C)n4)n3)cc2C1 CHEMBL5195687 IC50 28.0 nM
C[C@@H](Oc1cc(-c2ccc3c(c2)NC(=O)C32CCN(C)CC2)cnc1N)c1c(Cl)ccc(F)c1Cl CHEMBL3091723 IC50 28.9 nM
CC(C)NC(=O)[C@H]1CC[C@@H](n2/c(=N/C(=O)c3ccc(F)cc3)[nH]c3ccc(CN4CCC(C(C)(C)O)CC4)cc32)CC1 CHEMBL2172308 Kd 29.0 nM
Cc1nn(C2CCN(C)CC2)cc1-c1cnc(N)c(-c2nc3ccccc3o2)c1 CHEMBL2023350 IC50 30.0 nM
CCc1ccc2c(c1)c(=O)c(C(=O)Nc1ccc(Oc3ccnc4[nH]cc(-c5ccccc5)c34)c(F)c1)c(C)n2C CHEMBL4449055 IC50 30.0 nM
CCc1ccc2c(c1)c(=O)c(C(=O)Nc1ccc(Oc3ncnc4[nH]cc(-c5ccccc5)c34)cc1F)c(C)n2C CHEMBL4550377 IC50 30.0 nM
CC(=O)N1CC2CN(c3ccc(Nc4ncc(Cl)c(Nc5ccccc5-c5n[nH]c(C)n5)n4)cc3)CC2C1 CHEMBL5176724 IC50 30.0 nM
Cc1nc(-c2ccccc2Nc2nc(Nc3ccc(C(=O)NC4CC4)cc3)ncc2Cl)n[nH]1 CHEMBL5175081 IC50 30.0 nM
CC(=O)N1CCC(c2ccc(Nc3ncc(Cl)c(Nc4ccccc4-c4nc(C)n(C)n4)n3)cc2)CC1 CHEMBL5207577 IC50 30.0 nM
COc1cc2c(Oc3ccc(NS(=O)(=O)c4ccccc4C(F)(F)F)cc3F)ccnc2cc1OCCCN1CCCC(C)C1 CHEMBL4581109 IC50 31.0 nM
Nc1ncnc2onc(-c3ccc(NC(=O)Nc4cccc(C(F)(F)F)c4)cc3)c12 CHEMBL213505 pKi 31.62 nM
CN1CCN(Cc2ccc(-c3ccc(CO[C@H]4CCC[C@@H]4NC(=O)c4cc(-c5cnn(C)c5)cnc4N)cc3)cc2)CC1 CHEMBL4857737 pIC50 31.62 nM
CN1CCN(Cc2ccc(Nc3ncc(Cl)c(Nc4ccccc4C(=O)NC4CC4)n3)cc2)CC1 CHEMBL2022974 IC50 32.0 nM
CN1CCN(S(=O)(=O)c2ccc(-c3cn([C@H]4CC[C@H](O)CC4)c4nc(NCCC5CC5)ncc34)c(F)c2)CC1 CHEMBL3326005 IC50 32.0 nM
Cc1nc(-n2nc(Nc3ccc(OCCN4CCCC4)cc3)nc2N)c2ccccc2n1 CHEMBL4060051 IC50 32.0 nM
Cc1nc(-n2nc(Nc3ccc(N4CCN(C5CC6CCC5C6)CC4)cc3)nc2N)c2ccccc2n1 CHEMBL4083641 IC50 32.0 nM
CN1CCN(C2CCN(C(=O)Nc3cc(Oc4ccc(NC(=O)c5cn(C)c(=O)n(-c6ccc(F)cc6)c5=O)cc4)ncn3)CC2)CC1 CHEMBL4867209 IC50 32.0 nM
CN1CCC(CN2CCc3c(ncnc3Oc3ccc(NC(=O)c4cn(C5CC5)c(=O)n(-c5ccc(F)cc5)c4=O)cc3F)C2)CC1 CHEMBL4870992 IC50 32.0 nM
CC(C)(O)COc1ccc2c(Oc3ccc(Nc4nccc5[nH]cc(-c6ccccc6)c(=O)c45)cc3F)ccnc2c1 CHEMBL4747900 IC50 32.3 nM
CN1CCN(Cc2ccc(-c3cn4c5nc(ncc35)NCCCCNC(=O)[C@@H](N)CCC4)cc2)CC1 CHEMBL3973561 IC50 33.0 nM
CS(=O)(=O)N1CCC[C@H](c2csc(-c3ccccc3NC(=O)c3ncc[nH]3)n2)C1 CHEMBL4069884 IC50 33.0 nM
CCc1ccc2c(c1)c(=O)c(C(=O)Nc1ccc(Oc3ncnc4[nH]cc(-c5cnn(C)c5)c34)c(F)c1)c(C)n2C CHEMBL4468711 IC50 34.0 nM
C[C@]12O[C@H](C[C@]1(O)CO)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)CNC4=O CHEMBL603469 Kd 35.0 nM
CCn1cc(-c2ccc3c(c2)CCN3C(=O)Cc2cccc(OC(F)(F)F)c2)c2c(N)ncnc21 CHEMBL4281823 IC50 35.0 nM
COc1cc2c(Oc3ccc(NS(=O)(=O)c4cc(F)ccc4F)cc3F)ccnc2cc1OCCCN1CCOCC1 CHEMBL4521196 IC50 35.0 nM
COc1cc2nccc(Oc3ccc(Nc4nn(C)cc4C(=O)NC4CCCCC4)cc3)c2cc1OC CHEMBL5175952 IC50 35.0 nM
CNc1ncc2c(-c3ccc(OC)cc3)nn(CC3CCC(N)CC3)c2n1 CHEMBL2036630 IC50 36.0 nM
CN1CCN(Cc2ccc(-c3cn4c5nc(ncc35)NCCCCCCC(O)CCCC4)cc2)CC1 CHEMBL3956694 IC50 36.0 nM
COc1cc2c(Oc3ccc(NS(=O)(=O)c4cc(F)ccc4F)cc3F)ccnc2cc1OCCCN(C)C CHEMBL4471160 IC50 36.0 nM
COc1cc2c(Oc3ccc(NC(=O)C(C)c4nnc(-c5ccc(F)cc5)o4)cc3F)ccnc2cc1OCCCN1CCC(C)CC1 CHEMBL4776125 IC50 36.0 nM
CN1CCN(Cc2ccc(Nc3ncc(Cl)c(Nc4ccccc4-c4ncn(C)n4)n3)cc2)CC1 CHEMBL5189203 IC50 36.0 nM
CN1CCN(Cc2ccc(Nc3ncc(Cl)c(Nc4ccc(F)cc4S(=O)(=O)N4CCCC4)n3)cc2)CC1 CHEMBL2022977 IC50 37.0 nM
CCCCNc1ncc2c(-c3ccc(F)cc3)nn(C[C@H]3CC[C@H](N)CC3)c2n1 CHEMBL2036808 IC50 37.0 nM
NC1CCC(Cn2nc(-c3ccccc3)c3cnc(NCc4ccccc4)nc32)CC1 CHEMBL2036801 IC50 38.0 nM
NC1CCC(Cn2nc(-c3ccccc3)c3cnc(NCCCc4ccccc4)nc32)CC1 CHEMBL2036787 IC50 38.0 nM
CCCCNc1ncc(-c2ccc(CNC3CCCCC3)cn2)c(N[C@H]2CC[C@H](O)CC2)n1 CHEMBL3092795 IC50 38.0 nM
O=C(Nc1ccc(Oc2ncnc3[nH]cnc23)c(F)c1)c1cccn(-c2ccc(F)cc2)c1=O CHEMBL2346680 Kd 39.0 nM
COc1cc2ncnc(-n3nc(Nc4ccc(N5CCN(C)CC5)cc4)nc3N)c2cc1OC CHEMBL4069483 EC50 39.0 nM
COc1cc(Nc2ncc([N+](=O)[O-])c(Nc3ccccc3C(N)=O)n2)cc(OC)c1OC CHEMBL1241473 pKi 39.81 nM
CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3cccc(C(F)(F)F)c3)cc2)ccn1 CHEMBL1992306 pKi 39.81 nM
Cc1cc(C)c(C=C2C(=O)Nc3ccccc32)[nH]1 CHEMBL2002702 pKi 39.81 nM
Cc1ccc(F)c(NC(=O)Nc2ccc(-c3nsc4ncnc(N)c34)cc2)c1 CHEMBL262433 pKi 39.81 nM
NC(=O)c1cccc(-c2cnc3[nH]cc(-c4ccccc4)c3c2)c1 CHEMBL1982957 pKi 39.81 nM
Nc1ncc(-c2ccoc2)c2scc(-c3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12 CHEMBL1966514 pKi 39.81 nM
CN1CCN(c2ccc(C(=O)Nc3n[nH]c4ccc(Cc5cc(F)cc(F)c5)cc34)c(NC3CCOCC3)c2)CC1 CHEMBL1983268 pKi 39.81 nM
Cc1cc(-c2c(C)nn(C)c2C#N)ccc1-c1nnc(N(C)Cc2ccc3nccn3c2)o1 CHEMBL4875486 pIC50 39.81 nM
Nc1nc(Nc2ccc([C@H]3CC[C@H](N4CCOCC4)CC3)cc2)nn1-c1ccccn1 CHEMBL1835870 Ki 40.0 nM
CN1CCN(Cc2ccc(-c3cn4c5nc(ncc35)NCCCCCC(O)CCC4)cc2)CC1 CHEMBL3951096 IC50 40.0 nM
COc1cc2nccc(Oc3ccc(Nc4nn(C)cc4C(=O)Nc4ccc(F)cc4)cc3F)c2cc1OC CHEMBL5209372 IC50 40.1 nM
COc1cc2nccc(Oc3ccc(Nc4nn(C)cc4C(=O)NC4CCCCC4)cc3C)c2cc1OC CHEMBL5194396 IC50 40.4 nM
COc1cc2nccc(Oc3ccc(Nc4nn(C)cc4C(=O)NC4CCCCC4)cc3OC)c2cc1OC CHEMBL5188384 IC50 40.4 nM
NC1CCC(Cn2nc(-c3ccccc3)c3cnc(NCCc4ccccc4)nc32)CC1 CHEMBL2036803 IC50 41.0 nM
COCC1CN(C2CCN(c3cc(OC)c(Nc4ncc(Br)c(Nc5ccc6c(c5P(C)(C)=O)OCCO6)n4)cc3C)CC2)C1 CHEMBL5188373 IC50 41.0 nM
CCCCNc1ncc2c(-c3ccc(NC4CCNCC4)cc3)cn([C@H]3CC[C@H](O)CC3)c2n1 CHEMBL4291006 IC50 42.0 nM
Cc1c(C(=O)Nc2ccc(Oc3ncnc4[nH]cc(-c5ccccc5)c34)c(F)c2)c(=O)c2cc(C(C)(C)C)ccc2n1C CHEMBL4473545 IC50 42.0 nM
CS(=O)(=O)N1CCC[C@H](c2csc(-c3ccccc3NC(=O)c3nc(C#N)c[nH]3)n2)C1 CHEMBL4080569 IC50 43.0 nM
CCCCNc1ncc2c(C3CCN(C(=O)c4cc(C)nc(C)c4)CC3)cn([C@H]3CC[C@H](O)CC3)c2n1 CHEMBL4866538 IC50 43.0 nM
Cc1cc(NC(=O)c2cn(C(C)C)c(=O)n(-c3ccc(F)cc3)c2=O)ccc1Oc1ccnc(-c2cnn(C)c2)c1 CHEMBL4849593 IC50 45.6 nM
COc1cc2c(Oc3ccc(NS(=O)(=O)c4ccccc4C(F)(F)F)cc3F)ccnc2cc1OCCCCOC(C)=O CHEMBL4519394 IC50 46.0 nM
Cc1nc(-c2ccccc2Nc2nc(Nc3ccc(N4CCOCC4)cc3)ncc2Cl)n[nH]1 CHEMBL5173543 IC50 46.0 nM
CCCCCNc1ncc2c(-c3ccccc3)nn(CC3CCC(N)CC3)c2n1 CHEMBL2036796 IC50 47.0 nM
Nc1nc(Nc2ccc(OCCN3CCCC3)c(F)c2)nn1C(=O)c1ccc(N2CCOCC2)cc1 CHEMBL4095081 EC50 47.0 nM
CC[C@H]1C[C@@H]1Nc1ncc2c(C3CCN(C(=O)c4cc(C)nc(C)c4)CC3)cn([C@H]3CC[C@H](O)CC3)c2n1 CHEMBL4857351 IC50 48.0 nM
Cc1nc(-c2ccccc2Nc2nc(Nc3ccc4c(c3)CN(C3CC3)C4=O)ncc2Cl)n[nH]1 CHEMBL5187989 IC50 48.0 nM
CN1CCC(Cc2nc3ccc(Nc4ncc(Cl)c(Nc5ccccc5S(=O)(=O)N(C)C)n4)cn3n2)CC1 CHEMBL5204819 IC50 49.0 nM
CC(=O)N1CCN(c2ccc(Nc3ncc(Cl)c(Nc4ccccc4-c4nnn(C)n4)n3)cc2)CC1 CHEMBL5170873 IC50 49.0 nM
CNc1ncc2c(-c3ccc(-c4ccccc4)cc3)nn(CC3CCC(N)CC3)c2n1 CHEMBL2036788 IC50 50.0 nM
CN1CCN(Cc2ccc(-c3cn4c5nc(ncc35)NCCCCCCC(O)CCC4)cc2)CC1 CHEMBL3961597 IC50 50.0 nM
COc1cc2c(Oc3ccc(NS(=O)(=O)c4cc(F)ccc4F)cc3F)ccnc2cc1OCCCN1CCCCC1C CHEMBL4458062 IC50 50.0 nM
Cc1nc(-c2ccccc2Nc2nc(Nc3ccc(N4CCC(N(C)C)CC4)cc3)ncc2Cl)n[nH]1 CHEMBL5202025 IC50 50.0 nM
O=C1NCCc2[nH]c(-c3ccnc(C=Cc4ccccc4)c3)cc21 CHEMBL1997129 pKi 50.12 nM
Cc1ccc(-c2ccc(NC(=O)Nc3cccc(Br)c3)cc2)c2c(N)n[nH]c12 CHEMBL1973937 pKi 50.12 nM
Cc1cc(C)cc(NC(=O)Nc2ccc(NC(=O)c3csc4ncnc(N)c34)cc2)c1 CHEMBL1970203 pKi 50.12 nM
Nc1nccc2scc(-c3ccc(NC(=O)Nc4cccc(Cl)c4)cc3)c12 CHEMBL394790 pKi 50.12 nM
COc1ccc(-c2ccc(NC(=O)Nc3ccc(F)c(C)c3)cc2)c2c(N)noc12 CHEMBL1979093 pKi 50.12 nM
Cc1nc(-c2ccccc2Nc2nc(Nc3ccc(N4CCn5nccc5C4)cc3)ncc2Cl)n[nH]1 CHEMBL5195675 IC50 51.0 nM
COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl CHEMBL288441 Kd 52.0 nM
COc1cc2ncnc(-n3nc(Nc4ccc(OC5CCCN(C)C5)cc4)nc3N)c2cc1OC CHEMBL4098219 EC50 52.0 nM
Nc1nc(Nc2ccc(N3CCN(C4CC5CCC4C5)CC3)cc2)nn1-c1ncnc2c1sc1ncccc12 CHEMBL4071242 EC50 52.0 nM
COc1cc2c(Oc3ccc(NS(=O)(=O)c4cc(F)ccc4F)cc3F)ccnc2cc1OCCN1CCOCC1 CHEMBL4575854 IC50 52.0 nM
CCN1CCN(CCCOc2cc3nccc(Oc4c(F)cc(NC(=O)NN5C(=O)CSC5c5c(F)cccc5F)cc4F)c3cc2OC)CC1 CHEMBL4587222 IC50 53.0 nM
COc1cc2c(Oc3ccc(NS(=O)(=O)c4ccccc4C(F)(F)F)cc3F)ccnc2cc1OCCN1CCOCC1 CHEMBL4445932 IC50 54.0 nM
COc1cc2ncnc(-n3nc(Nc4ccc(N5CCN(C6CCCCC6)CC5)c(F)c4)nc3N)c2cc1OC CHEMBL4080190 EC50 55.0 nM
CN1CCC(N(C)c2ccc(Nc3ncc(Cl)c(Nc4ccccc4S(=O)(=O)N(C)C)n3)cc2)CC1 CHEMBL2023347 IC50 56.0 nM
CNc1ncc2c(-c3ccc(N4CCNCC4)nc3)nn(CC3CCC(N)CC3)c2n1 CHEMBL2036791 IC50 57.0 nM
Cc1c[nH]c2nc(Nc3ccc(N4CCN(C)CC4)c(F)c3)nc(-c3cccc(CC#N)c3)c12 CHEMBL3809908 IC50 58.0 nM
Cn1cc(-c2cnccc2Oc2ccc(NC(=O)c3cn(CC4CCOCC4)c(=O)n(-c4ccc(F)cc4)c3=O)cc2)cn1 CHEMBL4858649 IC50 58.3 nM
COc1ccc(CNc2ncc3c(-c4ccccc4)nn(CC4CCC(N)CC4)c3n2)cc1 CHEMBL2036802 IC50 59.0 nM
CN1CCN(Cc2ccc(Nc3ncc(Cl)c(Nc4ccccc4C(=O)N4CCCC4)n3)cc2)CC1 CHEMBL2022973 IC50 61.0 nM
COc1ccc(CCNc2ncc(C(=O)NCCCN3CCCC3=O)c(NC3CCCC3)n2)cc1OC CHEMBL2312290 IC50 61.0 nM
CCCCNc1ncc(-c2ccc(C(=O)NC3CCN(C)CC3)cn2)c(N[C@H]2CC[C@H](O)CC2)n1 CHEMBL3092793 IC50 61.0 nM
CCCc1ccc2c(c1)c(=O)c(C(=O)Nc1ccc(Oc3ncnc4[nH]cc(-c5ccccc5)c34)c(F)c1)c(C)n2C CHEMBL4517938 IC50 61.0 nM
Cc1csc2c(-n3nc(Nc4ccc(N5CCN(C6CC7CCC6C7)CC5)c(F)c4)nc3N)ncnc12 CHEMBL4067869 EC50 62.0 nM
COc1cc2c(Oc3ccc(NC(=O)NN4C(=O)CSC4c4c(F)cccc4F)c(F)c3)ccnc2cc1OCCCN1CCCC1 CHEMBL4171115 IC50 62.0 nM
CCCCNc1ncc(-c2ccc(CN(C)C)cn2)c(N[C@H]2CC[C@H](O)CC2)n1 CHEMBL3092791 IC50 63.0 nM
Cc1[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c(C)c1NC(=O)CCN1CCN(C)CC1 CHEMBL3288854 Ki 63.0 nM
CNC(=O)COc1ccc(Nc2nc(Nc3ccc(C)c(S(N)(=O)=O)c3)ncc2F)cc1 CHEMBL1978099 pKi 63.1 nM
Nc1ncc(-c2ccoc2)c2scc(-c3ccc(NC(=O)Nc4ccccc4F)cc3)c12 CHEMBL1965570 pKi 63.1 nM
Cc1n[nH]c2cccc(-c3ccc(NC(=O)Nc4cccc(C(F)(F)F)c4)cc3)c12 CHEMBL1970074 pKi 63.1 nM
CC(=O)N1CCN(C2CCC(n3nc(-c4ccc(NC(=O)c5cc6ccccc6n5C)cc4)c4c(N)ncnc43)CC2)CC1 CHEMBL1972584 pKi 63.1 nM
CNS(=O)(=O)c1ccccc1Nc1nc(Nc2cc(N3CCN(C(C)=O)CC3)ccc2OC)ncc1Br CHEMBL1971029 pKi 63.1 nM
CC(C)(C)c1ccc2nc(-c3n[nH]c4ccccc34)[nH]c2c1 CHEMBL1970104 pKi 63.1 nM
Cc1cc(-c2c(C)nn(C)c2C)ccc1-c1nnc(N(C)Cc2ccc3ncc(-c4cnn(C)c4)n3c2)o1 CHEMBL4852375 pIC50 63.1 nM
CCCC[C@H](C)Nc1ncc2c(-c3ccc(CN4CCN(C)CC4)cc3)cn([C@H]3CC[C@H](O)CC3)c2n1 CHEMBL4280761 IC50 64.0 nM
CC(C)n1cc(C(=O)Nc2ccc(Oc3ncnc4c3CN(C)CC4)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O CHEMBL4869791 IC50 64.0 nM
COc1cc2nccc(Oc3ccc(Nc4nn(C)cc4C(=O)Nc4ccc(OC(F)F)cc4)cc3F)c2cc1OC CHEMBL5183197 IC50 64.4 nM
O=C(c1ccc(-c2cn3c4nc(ncc24)NCCCCCCCC(O)CCCC3)cc1)N1CCOCC1 CHEMBL3916387 IC50 65.0 nM
COc1cc2nccc(Oc3ccc(Nc4nn(C)cc4C(=O)NC4CCC(F)(F)CC4)cc3F)c2cc1OC CHEMBL5182869 IC50 65.1 nM
COc1cc2c(Oc3ccc(NS(=O)(=O)c4c(Cl)cccc4Cl)cc3F)ccnc2cc1OCCCN1CCN(C)CC1 CHEMBL4437340 IC50 68.0 nM
CCCCNc1ncc(-c2ccc(CNCCO)cn2)c(N[C@H]2CC[C@H](O)CC2)n1 CHEMBL3092797 IC50 70.0 nM
CNc1ncc2c(-c3ccc(N4CCN(C)CC4)nc3)nn(CC3CCCC3)c2n1 CHEMBL4208852 IC50 70.0 nM
CC(C)c1nc2c(Oc3ccc(NC(=O)c4cccn(-c5ccc(F)cc5)c4=O)cc3F)ccnc2[nH]1 CHEMBL4285448 IC50 70.0 nM
COc1cc2c(Oc3ccc(NS(=O)(=O)c4ccccc4C(F)(F)F)cc3F)ccnc2cc1OCCCN1CCCCC1C CHEMBL4537492 IC50 70.0 nM
NC(=O)c1nnc(N[C@@H]2CCCC[C@@H]2N)nc1Nc1cccc2cc[nH]c12 CHEMBL3416026 Kd 71.0 nM
CCCCNc1ncc(-c2ccc(S(=O)(=O)N3CCOCC3)cn2)c(N[C@H]2CC[C@H](O)CC2)n1 CHEMBL3092792 IC50 72.0 nM
COc1cc2c(Oc3ccc(NS(=O)(=O)c4cc(F)ccc4F)cc3F)ccnc2cc1OCCCN1CCCCC1 CHEMBL4473577 IC50 72.0 nM
CCc1ccc2c(c1)c(=O)c(C(=O)Nc1ccc(Oc3ccnc(N)c3Cl)c(F)c1)c(C)n2C CHEMBL4456472 IC50 72.0 nM
Cc1c(C(=O)Nc2ccc(Oc3ncnc4[nH]cc(-c5ccccc5)c34)c(F)c2)c(=O)c2cc(OC(F)(F)F)ccc2n1C CHEMBL4549099 IC50 74.0 nM
COc1cc2nccc(Oc3ccc(NS(=O)(=O)c4ccccc4C(F)(F)F)cc3F)c2cc1OC CHEMBL4458636 IC50 77.0 nM
CCC(C(=O)Nc1ccc(Oc2ccnc3cc(OCCCN4CCC(C)CC4)c(OC)cc23)c(F)c1)c1nnc(-c2ccc(F)cc2)o1 CHEMBL4762473 IC50 77.0 nM
CCCOc1cc2nccc(Oc3ccc(NC(=O)C(F)(c4ccc(N)cc4)c4nnc(-c5ccccc5)o4)cc3F)c2cc1OC CHEMBL5288269 IC50 77.0 nM
Cc1ccc2c(c1)c(=O)c(C(=O)Nc1ccc(Oc3ncnc4[nH]cc(-c5ccccc5)c34)c(F)c1)c(-c1ccccc1)n2C CHEMBL4588522 IC50 78.0 nM
CCc1c(C(=O)Nc2ccc(Oc3ncnc4[nH]cc(-c5ccccc5)c34)c(F)c2)c(=O)c2cc(C)ccc2n1C CHEMBL4445218 IC50 78.0 nM
CCC[C@H](C)Nc1ncc2c(-c3ccnc(N4CCNCC4)c3)cn([C@H]3CC[C@H](O)CC3)c2n1 CHEMBL4289301 IC50 79.0 nM
COc1ccc(-c2ccc(NC(=O)Nc3cc(F)cc(F)c3)cc2)c2c(N)noc12 CHEMBL1969190 pKi 79.43 nM
Cc1nn(C)c(C)c1-c1ccc(-c2nnc(N(C)Cc3ccc4nccn4c3)o2)c(Cl)c1 CHEMBL4865752 pIC50 79.43 nM
Cc1cc(-c2c(C)nn(C)c2C)ccc1-c1nnc(N(C)Cc2ccc3nccn3c2)o1 CHEMBL4855381 pIC50 79.43 nM
CCC[C@H](C)Nc1ncc2c(-c3ccc(CNCCN(CC)CC)cc3)cn([C@H]3CC[C@H](O)CC3)c2n1 CHEMBL4277564 IC50 80.0 nM
COc1cc(Nc2ncc(C(F)(F)F)c(N3Cc4cccc(N(C)S(C)(=O)=O)c4C3)n2)cc(OC)c1 CHEMBL4457670 IC50 80.0 nM
CNc1ncc2c(-c3ccccc3)nn(C[C@H]3CC[C@H](N)CC3)c2n1 CHEMBL2036628 IC50 81.0 nM
CCCCC[C@H](C)Nc1ncc2c(-c3ccc(CN4CCN(C)CC4)cc3)cn([C@H]3CC[C@H](O)CC3)c2n1 CHEMBL4288009 IC50 81.0 nM
COc1cc(Nc2ncc(F)c(Nc3ccc4c(n3)NC(=O)C(C)(C)O4)n2)cc(OC)c1OC CHEMBL475251 Kd 82.0 nM
CN1CCN(Cc2ccc(Nc3ncc(Cl)c(-c4ccc(F)cc4S(=O)(=O)N(C)C)n3)cc2)CC1 CHEMBL2023345 IC50 82.0 nM
CNc1ncc2c(-c3ccccc3)nn(C[C@H]3CC[C@H](O)CC3)c2n1 CHEMBL2036626 IC50 83.0 nM
O=C(Nc1cccc(Cl)c1)Nc1ncc(CCNc2ncnc3ccsc23)s1 CHEMBL518051 IC50 84.0 nM
Cc1[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c(C)c1C(=O)NC[C@H](O)CN1CCOCC1 CHEMBL1721885 Kd 84.0 nM
CCCCNc1ncc(-c2ccc(CNC3CC3)cn2)c(N[C@H]2CC[C@H](O)CC2)n1 CHEMBL3092796 IC50 84.0 nM
CC(C)(C)c1cc2ncnc(-n3nc(Nc4ccc(N5CCN(C6CC7CCC6C7)CC5)c(Cl)c4)nc3N)c2s1 CHEMBL4093021 EC50 84.0 nM
CCC[C@H](C)Nc1ncc2c(-c3ccc(CN4C5CCC4CC5)cc3)cn([C@H]3CC[C@H](O)CC3)c2n1 CHEMBL4286701 IC50 84.0 nM
CCCCNc1ncc2c(-c3ccc(S(=O)(=O)N4CCOCC4)cc3)nn([C@H]3CC[C@H](O)CC3)c2n1 CHEMBL3326002 IC50 85.0 nM
Nc1nc(Nc2ccc(N3CCN(C4CC5CCC4C5)CC3)c(Cl)c2)nn1-c1ncnc2sccc12 CHEMBL4082743 EC50 85.0 nM
COc1ccc(NC(=O)c2cn(C)nc2Nc2ccc(Oc3ccnc4cc(OC)c(OC)cc34)c(F)c2)cc1 CHEMBL5169745 IC50 86.7 nM
CN1CCN(Cc2ccc(Nc3ncc(Cl)c(Nc4ccccc4C(=O)N(C)C)n3)cc2)CC1 CHEMBL2022969 IC50 88.0 nM
NS(=O)(=O)N1CCC[C@H](c2csc(-c3ccccc3NC(=O)c3ncc[nH]3)n2)C1 CHEMBL4088862 IC50 89.0 nM
CN1CCN(Cc2ccc(Nc3ncc(Cl)c(-c4ccc(F)cc4S(=O)(=O)N4CCCC4)n3)cc2)CC1 CHEMBL2023346 IC50 91.0 nM
COc1cc2c(Oc3ccc(NS(=O)(=O)c4cc(F)ccc4F)cc3F)ccnc2cc1OCCCCOC(C)=O CHEMBL4528959 IC50 91.0 nM
CCC[C@H](C)Nc1ncc2c(C3CCN(C(=O)[C@H]4CCCN(C)C4)CC3)cn([C@H]3CC[C@H](O)CC3)c2n1 CHEMBL4847691 IC50 91.0 nM
OC1CCCCCCCNc2ncc3c(-c4ccc(CN5CCOCC5)cc4)cn(c3n2)CCCC1 CHEMBL3986139 IC50 93.0 nM
CN1CCN(CCCOc2ccc3c(Oc4ccc(NS(=O)(=O)c5ccccc5C(F)(F)F)cc4F)ccnc3c2)CC1 CHEMBL4462011 IC50 93.0 nM
CCC[C@H](C)Nc1ncc2c(C3CCN(CC4CCNCC4)CC3)cn([C@H]3CC[C@H](O)CC3)c2n1 CHEMBL4878774 IC50 98.0 nM
COc1ccc2c(c1)c(=O)c(C(=O)Nc1ccc(Oc3ncnc4[nH]cc(-c5ccccc5)c34)c(F)c1)c(C)n2C CHEMBL4593206 IC50 99.0 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4nc(N)nc(N)c34)cc2)c1 CHEMBL1973145 pKi 100.0 nM
Cc1ccc(-c2cnc(N)c3c(-c4ccc(NC(=O)Nc5cccc(F)c5)cc4)csc23)cn1 CHEMBL1988075 pKi 100.0 nM
CCCCOc1ncnc2[nH]cc(-c3ccccc3)c12 CHEMBL1996817 pKi 100.0 nM
Cc1cccc(NC(=O)Nc2ccc(NC(=O)c3csc4ncnc(N)c34)cc2)c1 CHEMBL1965507 pKi 100.0 nM
Cc1c[nH]c2nc(Nc3ccc(N4CCN(CCO)CC4)cc3)nc(-c3cccc(CC#N)c3)c12 CHEMBL2023352 IC50 100.0 nM
CCCCNc1ncc2c(-c3ccccc3)nn(CC3CCC(N)CC3)c2n1 CHEMBL2036795 IC50 100.0 nM
CCC(C)CNc1ncc2c(-c3ccc(CN4CCN(C)CC4)cc3)cn([C@H]3CC[C@H](O)CC3)c2n1 CHEMBL4287078 IC50 100.0 nM
Cc1ccc2c(c1)c(=O)c(C(=O)Nc1ccc(Oc3ncnc4[nH]cc(-c5ccccc5)c34)c(F)c1)c(C)n2C CHEMBL4469879 IC50 100.0 nM
Cc1cc(-c2cnn(C)c2C)ccc1-c1nnc(N(C)Cc2ccc3nccn3c2)o1 CHEMBL4873217 pIC50 100.0 nM
Cc1cc(-c2c(C)nn(C)c2C)cnc1-c1nnc(N(C)Cc2ccc3ncc(-c4ccc(CN(C)C)cc4)n3c2)o1 CHEMBL4879190 pIC50 100.0 nM
Cc1nc(-c2ccccc2Nc2nc(Nc3ccc(C(=O)NC4CCCC4)cc3)ncc2Cl)n[nH]1 CHEMBL5183041 IC50 100.0 nM
COc1cc2nccc(Oc3ccc(NS(=O)(=O)c4ccccc4C(F)(F)F)cc3F)c2cc1OCCCN1CCN(C)CC1 CHEMBL4520339 IC50 101.0 nM
Cc1nc(-c2ccccc2Nc2nc(Nc3ccc(C(=O)NC4CC4)nc3)ncc2Cl)n[nH]1 CHEMBL5183908 IC50 101.0 nM
CCc1ccc2c(c1)c(=O)c(C(=O)Nc1ccc(Oc3ncnc4[nH]cc(-c5ccccc5)c34)cc1)c(C)n2C CHEMBL4541303 IC50 105.0 nM
Cc1[nH]c(/C=C2\C(=O)Nc3ccc(S(=O)(=O)Cc4c(Cl)cccc4Cl)cc32)c(C)c1C(=O)N1CCC[C@@H]1CN1CCCC1 CHEMBL450786 Kd 110.0 nM
O=S(=O)(c1ccc(-c2cn3c4nc(ncc24)NCCCCCCCC(O)CCCC3)cc1)N1CCOCC1 CHEMBL3963528 IC50 110.0 nM
O=C(O)c1ccc(-c2c[nH]c3ncc(-c4ccccc4)cc23)c(F)c1 CHEMBL4093667 IC50 111.0 nM
O=C(O)c1ccc(-c2c[nH]c3ncc(-c4ccccc4)cc23)cc1F CHEMBL4083405 IC50 118.0 nM
CCC[C@H](C)Nc1ncc2c(-c3ccc(CN4CCN(C)CC4)cc3)cn([C@H]3CC[C@H](O)CC3)c2n1 CHEMBL4287582 IC50 118.0 nM
COc1cc2nccc(Oc3ccc(Nc4nn(C)cc4C(=O)NC4CCOCC4)cc3F)c2cc1OC CHEMBL5197327 IC50 119.7 nM
OC1CCCCCCCNc2ncc3c(-c4ccncc4)cn(c3n2)CCCC1 CHEMBL3973830 IC50 120.0 nM
CN1CCN(Cc2ccc(-c3cn4c5nc(ncc35)NCCCCCC(O)CCCC4)cc2)CC1 CHEMBL3920231 IC50 120.0 nM
CNc1ncc2c(-c3ccc(N4CCNCC4)nc3)nn(CC3CCCC3)c2n1 CHEMBL4213003 IC50 120.0 nM
N[C@H]1CCCCNc2nc(ncc2C(=O)NCc2ccc(F)cc2)NCCCCCCNC1=O CHEMBL4290493 IC50 120.0 nM
COc1cc2c(Oc3ccc(NS(=O)(=O)c4cc(F)ccc4F)cc3F)ccnc2cc1OCCCNC(=O)OC(C)(C)C CHEMBL4475420 IC50 120.0 nM
Cc1cc(C(=O)N2CCC(c3cn([C@H]4CC[C@H](O)CC4)c4nc(NCc5ccccc5)ncc34)CC2)cc(C)n1 CHEMBL4849169 IC50 120.0 nM
COc1cc2c(Oc3ccc(NS(=O)(=O)c4ccccc4F)cc3F)ccnc2cc1OCCCN1CCN(C)CC1 CHEMBL4464365 IC50 121.0 nM
CCCC(C)Nc1ncc2c(-c3ccc(CN4CCN(C)CC4)cc3)cn([C@H]3CC[C@H](O)CC3)c2n1 CHEMBL4282624 IC50 125.0 nM
Cc1ccc(F)c(NC(=O)Nc2ccc(-c3cccc4[nH]nc(N)c34)cc2)c1 CHEMBL223360 pKi 125.89 nM
COc1cc2c(cc1Nc1nc(Nc3cccc(F)c3C(N)=O)c3cc[nH]c3n1)N(C(=O)CN(C)C)CC2 CHEMBL461876 pKi 125.89 nM
CN1CCN(C2CCC(n3cc(-c4ccc(Oc5ccccc5)cc4)c4c(N)ncnc43)CC2)CC1 CHEMBL1997617 pKi 125.89 nM
COc1cc2c(Nc3cnc(NC(=O)c4cccn4C)nc3)ncnc2cc1OCCCNC1CCCC1 CHEMBL4751475 pIC50 125.89 nM
Cc1cc(-c2c(C)nn(C)c2C)ccc1-c1nnc(N(C)Cc2ccc3ncc(-c4cnn(CCN(C)C)c4)n3c2)o1 CHEMBL4846456 pIC50 125.89 nM
Cc1cc(-c2c(C)nn(C)c2C)cnc1-c1nnc(N(C)Cc2ccc3ncc(-c4ccc(CN(C)C)cn4)n3c2)o1 CHEMBL4879167 pIC50 125.89 nM
CCc1nc(C(N)=O)c(Nc2ccc3c(c2)C(=O)N2CCNCC2CO3)nc1NC1CCOCC1 CHEMBL4462288 IC50 126.0 nM
CCCCNc1ncc(-c2ccc(CN3CCC(F)(F)CC3)cn2)c(N[C@H]2CC[C@H](O)CC2)n1 CHEMBL3092790 IC50 130.0 nM
CS(=O)(=O)N1CCC[C@H](c2csc(-c3ccccc3NC(=O)c3nc(Cl)c[nH]3)n2)C1 CHEMBL4101465 IC50 130.0 nM
Cc1csc2c(-n3nc(Nc4ccc(N5CCN([C@H]6C[C@@H]7CC[C@H]6C7)CC5)c(Cl)c4)nc3N)nc(Cl)nc12 CHEMBL4100738 EC50 136.0 nM
COc1cc(Oc2ccnc3cc(OC)c(OC)cc23)ccc1NC(=O)NC(C)c1nccs1 CHEMBL1908396 Kd 140.0 nM
CCC[C@H](C)Nc1ncc2c(C3CCN(C(=O)C4CCN(C)CC4)CC3)cn([C@H]3CC[C@H](O)CC3)c2n1 CHEMBL4877058 IC50 140.0 nM
COc1cc2nccc(Oc3ccc(Nc4nn(C)cc4C(=O)NC(C)(C)C)cc3F)c2cc1OC CHEMBL5197167 IC50 142.2 nM
CNc1ncc2c(-c3cccc(OC)c3)nn(CC3CCC(N)CC3)c2n1 CHEMBL2036631 IC50 150.0 nM
CN1CCN(Cc2ccc(-c3cn4c5nc(ncc35)NCCCCNC(=O)[C@@H](N)CCCC4)cc2)CC1 CHEMBL3961508 IC50 150.0 nM
Cc1ccc2c(c1)c(=O)c(C(=O)Nc1ccc(Oc3ncnc4[nH]cc(-c5ccccc5)c34)c(F)c1)cn2C CHEMBL4565473 IC50 150.0 nM
CCn1c(C)c(C(=O)Nc2ccc(Oc3ncnc4[nH]cc(-c5ccccc5)c34)c(F)c2)c(=O)c2cc(C)ccc21 CHEMBL4516966 IC50 150.0 nM
Cc1c(C(=O)Nc2ccc(Oc3ncnc4[nH]cc(-c5ccccc5)c34)c(F)c2)c(=O)c2cc(C(F)(F)F)ccc2n1C CHEMBL4471186 IC50 150.0 nM
Cn1cc(-c2cnccc2Oc2ccc(NC(=O)C3Cc4ccncc4N(c4ccc(F)cc4)C3=O)cc2)cn1 CHEMBL4866212 IC50 150.0 nM
CCC[C@H](C)Nc1ncc2c(-c3ccc(CN4CC[C@H](N(C)C)C4)cc3)cn([C@H]3CC[C@H](O)CC3)c2n1 CHEMBL4294601 IC50 152.0 nM
CCc1ccc2c(c1)c(=O)c(C(=O)Nc1ccc(Oc3ncnc4[nH]ccc34)c(F)c1)c(C)n2C CHEMBL4583626 IC50 157.0 nM
CN1CCN(Cc2ccc3c(c2)Cc2c(-c4csc(C#CCOCC5CC5)c4)n[nH]c2-3)CC1 CHEMBL2002446 pKi 158.49 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4cccc(Cl)c4)c3)cc12 CHEMBL1974870 pKi 158.49 nM
CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1 CHEMBL1336 pKi 158.49 nM
CNC(=O)c1ccccc1Sc1ccc2c(C=Cc3ccccn3)n[nH]c2c1 CHEMBL1988437 pKi 158.49 nM
Nc1nccc2scc(-c3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12 CHEMBL231209 pKi 158.49 nM
Cc1cnc(Nc2ccc(OCCN3CCCC3)cc2)nc1Nc1cccc(S(=O)(=O)NC(C)(C)C)c1 CHEMBL1287853 Kd 160.0 nM
Cc1c(O)c(O)c2c(c1C=O)[C@@H]1O[C@H](O2)c2c(C)c(O)c(O)c(O)c2C1=O CHEMBL3104851 IC50 160.0 nM
CCC[C@H](C)Nc1ncc2c(-c3cnn(C4CCNCC4)c3)cn([C@H]3CC[C@H](O)CC3)c2n1 CHEMBL4293116 IC50 161.0 nM
CNC(=O)c1ccc(-c2ccc(=O)n(CCc3ccc4ncc(-c5cnn(C6CCOCC6)c5)cc4c3)n2)cc1C(F)(F)F CHEMBL5191797 IC50 164.2 nM
Cc1nnc(-c2ccccc2Nc2nc(Nc3ccc(CN4CCN(C)CC4)cc3)ncc2Cl)o1 CHEMBL5183492 IC50 169.0 nM
O=C(Nc1ccc(Oc2ncnc3[nH]cnc23)c(F)c1)c1cccn(-c2ccc(C(F)(F)F)cc2)c1=O CHEMBL2348264 Kd 170.0 nM
CCCCNc1ncc(-c2ccc(NC(=O)C3CCN(C)CC3)cn2)c(N[C@H]2CC[C@H](O)CC2)n1 CHEMBL3092794 IC50 170.0 nM
CC1(C)c2cc(C3CCN(CC4CCOCC4)CC3)ccc2C(=O)c2c1[nH]c1cc(C#N)ccc21 CHEMBL3735648 IC50 170.0 nM
CN1CCN(Cc2ccc(-c3cn4c5nc(ncc35)NCCCCCCCCNC(=O)[C@@H](N)CCC4)cc2)CC1 CHEMBL3962587 IC50 170.0 nM
COc1cc2c(Oc3ccc(NS(=O)(=O)c4ccccc4C(F)(F)F)cc3F)ccnc2cc1OCCCNC(=O)OC(C)(C)C CHEMBL4578900 IC50 170.0 nM
C=C(C)c1ccc2c(c1)c(=O)c(C(=O)Nc1ccc(Oc3ncnc4[nH]cc(-c5ccccc5)c34)c(F)c1)c(C)n2C CHEMBL4515742 IC50 170.0 nM
CCCCNc1ncc(C(=O)NC2CCN(CCCF)CC2)c(N[C@H]2CC[C@H](O)CC2)n1 CHEMBL5196154 IC50 170.0 nM
CC(C)n1nc(C(=O)Nc2ccc(Oc3ccncc3-c3cnn(C)c3)cc2)c(=O)n(-c2ccc(F)cc2)c1=O CHEMBL4856528 IC50 178.6 nM
O=C(c1ccc(/C=C/c2n[nH]c3ccccc23)cc1)N1CCNCC1 CHEMBL1908397 Kd 180.0 nM
CCCNc1ncc2c(-c3ccccc3)nn(CC3CCC(N)CC3)c2n1 CHEMBL2036794 IC50 180.0 nM
CCCCNc1ncc(-c2ccccn2)c(N[C@H]2CC[C@H](CN)CC2)n1 CHEMBL3092800 IC50 180.0 nM
CCCCNc1ncc(-c2ccc(N3CCN(C)CC3)cn2)c(N[C@H]2CC[C@H](O)CC2)n1 CHEMBL3092805 IC50 180.0 nM
OC1CCCCCCCNc2ncc3c(-c4cccnc4)cn(c3n2)CCCC1 CHEMBL3932605 IC50 180.0 nM
OC1CCCCCCCNc2ncc3c(-c4ccc(N5CCOCC5)cc4)cn(c3n2)CCCC1 CHEMBL3969591 IC50 180.0 nM
O=C(Nc1ccc(-c2cn3c4nc(ncc24)NCCCCCCCC(O)CCCC3)cc1)N1CCOCC1 CHEMBL3925379 IC50 180.0 nM
O=C(O)c1ccc(-c2c[nH]c3ncc(-c4ccccc4)cc23)cc1 CHEMBL550795 IC50 182.0 nM
COc1cc2c(Oc3ccc(NS(=O)(=O)c4ccccc4Cl)cc3F)ccnc2cc1OCCCN1CCN(C)CC1 CHEMBL4476648 IC50 184.0 nM
Cn1cc(-c2cnccc2Oc2ccc(NC(=O)c3cn(C)c(=O)n(-c4ccc(F)cc4)c3=O)cc2)cn1 CHEMBL4856829 IC50 184.8 nM
Cc1nc(-c2ccccc2Nc2nc(Nc3ccc4c(c3)C(=O)N(C3CC3)C4)ncc2Cl)n[nH]1 CHEMBL5197239 IC50 185.0 nM
CCOc1cc2ncc(C#N)c(Nc3ccc(OCc4ccccn4)c(Cl)c3)c2cc1NC(=O)/C=C/CN(C)C CHEMBL180022 Kd 190.0 nM
CNc1ncc2c(-c3ccccc3)nn(C[C@H]3CC[C@@H](O)CC3)c2n1 CHEMBL2036627 IC50 190.0 nM
CCC[C@H](C)Nc1ncc2c(C3CCN(C4CCNCC4)CC3)cn([C@H]3CC[C@H](O)CC3)c2n1 CHEMBL4878118 IC50 190.0 nM
CCC[C@H](C)Nc1ncc2c(-c3ccc(S(=O)(=O)N4CCN(C)CC4)cc3F)cn([C@H]3CC[C@H](O)CC3)c2n1 CHEMBL4284392 IC50 191.0 nM
CCc1ccc2c(c1)c(=O)c(C(=O)Nc1ccc(Oc3cccc4occ(-c5ccccc5)c34)c(F)c1)c(C)n2C CHEMBL4464266 IC50 192.0 nM
COc1cc2ncnc(-n3nc(Nc4ccc(N5CC[C@H](N(C)C)C5)cc4)nc3N)c2cc1OC CHEMBL4088067 EC50 193.0 nM
CN(c1ncccc1CNc1nc(Nc2ccc3c(c2)CC(=O)N3)ncc1C(F)(F)F)S(C)(=O)=O CHEMBL1084546 pKi 199.53 nM
Cc1cc(Nc2cc(N3CCN(C)CC3)nc(Sc3ccc(NC(=O)C4CC4)cc3)n2)n[nH]1 CHEMBL572878 pKi 199.53 nM
OCC(CO)Nc1ncnc2[nH]cc(-c3ccccc3)c12 CHEMBL1992922 pKi 199.53 nM
Cc1[nH]c(C=C2C(=O)Nc3ccccc32)c(C)c1CCC(=O)O CHEMBL2007064 pKi 199.53 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4ccc(Cl)c(Cl)c4)c3)cc12 CHEMBL1991063 pKi 199.53 nM
O=C(Cc1ccccc1)Nc1cccc(-c2nc3sccn3c2-c2ccnc(Nc3ccc(N4CCOCC4)cc3)n2)c1 CHEMBL1090356 pKi 199.53 nM
Fc1cnc(Nc2ccccc2)nc1Nc1ccccc1 CHEMBL491758 pKi 199.53 nM
O=S(=O)(c1ccc(Nc2ncc(N3CCOCC3)c(Nc3ccccc3)n2)cc1)N1CCCCC1 CHEMBL4750302 pIC50 199.53 nM
Cc1cc(-c2c(C)nn(C)c2C)ccc1-c1nnc(N(C)Cc2ccc3ncc(-c4ccccc4)n3c2)o1 CHEMBL4853066 pIC50 199.53 nM
Cc1c[nH]c(C(=O)Nc2ccccc2-c2nc([C@H]3CCCN(S(C)(=O)=O)C3)cs2)n1 CHEMBL4104797 IC50 200.0 nM
Cc1c(C(=O)Nc2ccc(Oc3ncnc4[nH]cc(-c5ccccc5)c34)c(F)c2)c(=O)c2cc(C3CCCC3)ccc2n1C CHEMBL4566072 IC50 200.0 nM
CCCCNc1ncc(C(=O)NC2CCN(CCF)CC2)c(N[C@H]2CC[C@H](O)CC2)n1 CHEMBL5171919 IC50 200.0 nM
COc1cc2c(Oc3ccc(NS(=O)(=O)c4cc(Cl)ccc4Cl)cc3F)ccnc2cc1OCCCN1CCN(C)CC1 CHEMBL4441242 IC50 201.0 nM
COc1cc2c(Oc3ccc(NS(=O)(=O)c4ccc(F)c(Cl)c4)cc3F)ccnc2cc1OCCCN1CCN(C)CC1 CHEMBL4460286 IC50 202.0 nM
CCC[C@H](C)Nc1ncc2c(-c3ccc(NC4CCNCC4)cc3)cn([C@H]3CC[C@H](O)CC3)c2n1 CHEMBL4295042 IC50 206.0 nM
CCC(CC)CNc1ncc2c(-c3ccc(CN4CCN(C)CC4)cc3)cn([C@H]3CC[C@H](O)CC3)c2n1 CHEMBL4279154 IC50 206.0 nM
O=C(Nc1ccc(Oc2ncnc3[nH]cnc23)c(F)c1)c1cccn(-c2cccc(F)c2)c1=O CHEMBL2348263 Kd 210.0 nM
CS(=O)(=O)N1CCC[C@@H](c2csc(-c3ccccc3NC(=O)c3ncc[nH]3)n2)C1 CHEMBL4104287 IC50 210.0 nM
CCC[C@H](C)Nc1ncc2c(C3CCN(C(=O)c4ccnc(C)c4)CC3)cn([C@H]3CC[C@H](O)CC3)c2n1 CHEMBL4862333 IC50 210.0 nM
CCC[C@H](C)Nc1ncc2c(-c3cccc(CN4CCN(C)CC4)c3)cn([C@H]3CC[C@H](O)CC3)c2n1 CHEMBL4288213 IC50 213.0 nM
Cc1csc2c(-n3nc(Nc4ccc(N5CCN([C@@H]6C[C@H]7CC[C@@H]6C7)CC5)c(Cl)c4)nc3N)nc(Cl)nc12 CHEMBL4071540 EC50 216.0 nM
CCc1nc(C(N)=O)c(Nc2ccc3c(c2)C(=O)N2CCN(C(C)C)CC2CO3)nc1NC1CCOCC1 CHEMBL4475960 IC50 216.0 nM
CCC[C@H](C)Nc1ncc2c(-c3ccc(CN4CCOCC4)cc3)cn([C@H]3CC[C@H](O)CC3)c2n1 CHEMBL4291202 IC50 218.0 nM
COc1cc2c(Oc3ccc(NS(=O)(=O)c4ccccc4)cc3F)ccnc2cc1OCCCN1CCN(C)CC1 CHEMBL4591609 IC50 218.0 nM
CCCCNc1ncc(C(=O)NC2CCN(CC3CC3)CC2)c(N[C@H]2CC[C@H](O)CC2)n1 CHEMBL5195969 IC50 218.0 nM
CNc1ncc2c(-c3ccc(C(F)(F)F)cc3)nn(CC3CCC(N)CC3)c2n1 CHEMBL2036633 IC50 220.0 nM
Cc1c(O)c(O)c(O)c(C=O)c1-c1cc2c(C=O)c(C)c(O)c(O)c2o1 CHEMBL3104855 IC50 220.0 nM
CCC[C@H](C)Nc1ncc2c(C3CCN(C(=O)[C@@H]4CCCCN4C)CC3)cn([C@H]3CC[C@H](O)CC3)c2n1 CHEMBL4857561 IC50 220.0 nM
CCC[C@H](C)Nc1ncc2c(-c3cccc(N4CCN(C)CC4)c3)cn([C@H]3CC[C@H](O)CC3)c2n1 CHEMBL4281432 IC50 230.0 nM
Cc1c(C(=O)Nc2ccc(Oc3ncnc4[nH]cc(-c5ccccc5)c34)c(F)c2)c(=O)c2cc(C3CC3)ccc2n1C CHEMBL4470280 IC50 230.0 nM
CCNC(=O)c1cn(C)nc1Nc1ccc(Oc2ccnc3cc(OC)c(OC)cc23)c(F)c1 CHEMBL5191629 IC50 237.8 nM
COc1cc2c(Oc3ccc(NS(=O)(=O)c4ccccc4C(F)(F)F)cc3F)ccnc2cc1OCCCN CHEMBL4547776 IC50 238.0 nM
CN1CCN(Cc2ccc(Nc3ncc(Cl)c(Nc4ccc(F)cc4S(=O)(=O)N4CCOCC4)n3)cc2)CC1 CHEMBL2022976 IC50 240.0 nM
CCC[C@H](C)Nc1ncc2c(C3CCNCC3)cn([C@H]3CC[C@H](O)CC3)c2n1 CHEMBL4850498 IC50 240.0 nM
CCC[C@H](C)Nc1ncc2c(C3CCN(C(=O)c4ccncc4)CC3)cn([C@H]3CC[C@H](O)CC3)c2n1 CHEMBL4867544 IC50 240.0 nM
COc1cc2/c(=N/c3ccc(Br)cc3F)nc[nH]c2cc1OCC1CCN(C)CC1 CHEMBL24828 Kd 250.0 nM
Cc1ccccc1-c1c(C(=O)O)n(CCCOc2cccc3ccccc23)c2ccccc12 CHEMBL1987793 pKi 251.19 nM
Cc1cccc(NC(=O)Nc2ccc(-c3cccc4[nH]nc(N)c34)cc2)c1 CHEMBL220057 pKi 251.19 nM
O=C(NC(CO)c1ccccc1)N1CC=C(c2c[nH]c3ncccc23)CC1 CHEMBL1964937 pKi 251.19 nM
CNC(=O)C=Cc1cnc(N)c2c(-c3cc(F)c4[nH]c(C)cc4c3)csc12 CHEMBL2006778 pKi 251.19 nM
O=C(Nc1cnc2[nH]cc(-c3ccccc3)c2c1)c1c(F)cccc1F CHEMBL1996979 pKi 251.19 nM
COc1cc2ncn(-c3cc(OCc4ccccc4C(F)(F)F)c(C(=O)O)s3)c2cc1OC CHEMBL474432 pKi 251.19 nM
Nc1ncnc2c1sc1ncnc(N)c12 CHEMBL1976090 pKi 251.19 nM
CN1CCN(c2ccc3nc(-c4c(N)c5c(F)cccc5[nH]c4=O)[nH]c3c2)CC1 CHEMBL522892 pKi 251.19 nM
Nc1ncnc2sc3c(c12)-c1ccc(NC(=O)Nc2ccccc2)cc1CC3 CHEMBL1994693 pKi 251.19 nM
O=C(NNC(=S)Nc1ccc(F)cc1)C(O)(c1ccccc1)c1ccccc1 CHEMBL1975138 pKi 251.19 nM
O=C1NN=Cc2c[nH]c3cc(NC(=O)C4CC4c4ccccc4)cc1c23 CHEMBL1969502 pKi 251.19 nM
OCCCNc1ncnc2[nH]cc(-c3ccccc3)c12 CHEMBL2000071 pKi 251.19 nM
COc1cc2ncn(-c3cc(OCc4ccccc4C(F)(F)F)c(C(N)=O)s3)c2cc1OC CHEMBL514499 pKi 251.19 nM
Cc1ccccc1NC(=O)Nc1ccc(NC(=O)c2csc3ncnc(N)c23)cc1 CHEMBL1980144 pKi 251.19 nM
Cc1c(C(=O)Nc2ccc(Oc3ccncc3-c3cnn(C)c3)cc2)c(=O)n(-c2ccccc2)n1C CHEMBL4845715 IC50 253.9 nM
CCCCNc1ncc(C(=O)NCc2ccc(S(N)(=O)=O)cc2)c(N[C@H]2CC[C@H](O)CC2)n1 CHEMBL3093755 IC50 260.0 nM
CCCCNc1ncc(-c2ccc(CN3CCN(C)CC3)cn2)c(N[C@H]2CC[C@H](O)CC2)n1 CHEMBL3092806 IC50 260.0 nM
CCN1CCN(c2ccc(-c3nn(CC4CCCC4)c4nc(NC)ncc34)cn2)CC1 CHEMBL4213775 IC50 260.0 nM
COc1cc2nccc(Oc3ccc(Nc4nn(C)cc4C(=O)Nc4cccc(F)c4)cc3F)c2cc1OC CHEMBL5196451 IC50 265.5 nM
CCCCNc1ncc(-c2ccc(CN3CCOCC3)cn2)c(N[C@H]2CC[C@H](O)CC2)n1 CHEMBL3092807 IC50 270.0 nM
CCC[C@H](C)Nc1ncc2c(C3CCN(Cc4cc(C)nc(C)c4)CC3)cn([C@H]3CC[C@H](O)CC3)c2n1 CHEMBL4878347 IC50 270.0 nM
CCC[C@H](C)Nc1ncc2c(C3CCN(C(=O)c4ccnnc4)CC3)cn([C@H]3CC[C@H](O)CC3)c2n1 CHEMBL4851097 IC50 280.0 nM
COc1cc(Oc2ccnc3cc(OC)c(OC)cc23)ccc1NS(=O)(=O)c1ccccc1C(F)(F)F CHEMBL4522053 IC50 289.0 nM
Cc1cnc(Nc2ccc(CN3CCN(C)CC3)cc2)nc1-c1ccc(C(C)(C)C#N)cc1 CHEMBL2022964 IC50 290.0 nM
CNC(=O)c1c(F)cccc1Nc1nc(Nc2cc3c(cc2OC)CCN3C(=O)CN(C)C)nc2[nH]ccc12 CHEMBL464552 Kd 300.0 nM
O=C(Nc1ccc(S(=O)(=O)N2CCOCC2)cc1)c1cnc(NCCC2CC2)nc1N[C@H]1CC[C@H](O)CC1 CHEMBL3093627 IC50 300.0 nM
CN1CCN(Cc2ccc(-c3cn4c5nc(ncc35)NCCCCCCNC(=O)[C@@H](N)CCC4)cc2)CC1 CHEMBL3935102 IC50 300.0 nM
COc1cc2nccc(Oc3ccc(NS(=O)(=O)c4ccccc4OC(F)(F)F)c(F)c3)c2cc1OC CHEMBL4473808 IC50 300.0 nM
COc1ccc(-n2cc(-c3n[nH]c4cc(Cl)c(N[C@@H]5CCNC5)cc34)cn2)cc1 CHEMBL4871523 IC50 300.0 nM
CO[C@@H]1[C@H](NCCOCCOCCOCCNC(=O)CCC2=[N+]3C(=Cc4c(C)cc(C)n4[B-]3(F)F)C=C2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL4465866 Kd 313.0 nM
Cc1ccc(NC(=O)Nc2ccc(NC(=O)c3csc4ncnc(N)c34)cc2)cc1 CHEMBL1972576 pKi 316.23 nM
Cc1ccc(F)c(NC(=O)Nc2ccc(-c3ccc4nccnc4c3N)cc2)c1 CHEMBL1971649 pKi 316.23 nM
COc1cc2c(Oc3ccc4[nH]c(C)cc4c3F)ncnc2cc1OCCCN1CCCC1 CHEMBL491473 pKi 316.23 nM
Cc1cccc(Nc2nccc(Nc3c(NC(C)C(C)(C)C)c(=O)c3=O)n2)c1 CHEMBL1969523 pKi 316.23 nM
Nc1ncnc2sc(Br)c(-c3ccc(NC(=O)Cc4cccc(Cl)c4)cc3)c12 CHEMBL1980896 pKi 316.23 nM
COc1ccc(C=NNc2ncnc3c2[nH]c2ccccc23)cc1OC CHEMBL1974664 pKi 316.23 nM
Cc1cc(-c2c(C)nn(C)c2C)cnc1-c1nnc(N(C)Cc2ccc3ncc(-c4cccc(CN(C)C)c4)n3c2)o1 CHEMBL4873714 pIC50 316.23 nM
Nc1nc(Nc2ccc(OCCN3CCCC3)c(F)c2)nn1-c1ccccn1 CHEMBL4067670 EC50 334.0 nM
COc1ccc(-c2cn3c4nc(ncc24)NCCCCCCCC(O)CCCC3)cc1 CHEMBL3934278 IC50 340.0 nM
O=C(O)c1cc(F)cc(-c2c[nH]c3ncc(-c4ccccc4)cc23)c1 CHEMBL4101393 IC50 340.0 nM
CN1CCN(Cc2ccc(-c3cn([C@H]4CC[C@H](O)CC4)c4nc(NC5CCCCC5)ncc34)cc2)CC1 CHEMBL4292435 IC50 340.0 nM
CCC[C@H](C)Nc1ncc2c(C3CCN(C(=O)c4ccncn4)CC3)cn([C@H]3CC[C@H](O)CC3)c2n1 CHEMBL4854618 IC50 340.0 nM
COc1cc2nccc(Oc3ccc(NS(=O)(=O)c4ccccc4C(F)(F)F)cc3)c2cc1OC CHEMBL4451421 IC50 350.0 nM
COc1cc2c(Oc3ccc(NS(=O)(=O)c4cccc(C(F)(F)F)c4)cc3F)ccnc2cc1OCCCN1CCN(C)CC1 CHEMBL4442793 IC50 354.0 nM
CCc1nc(C(N)=O)c(Nc2ccc3c(c2)C(=O)N2CCN(C)CC2CO3)nc1NC1CCOCC1 CHEMBL4592943 IC50 356.0 nM
NC1CCC(Cn2nc(-c3ccccc3)c3cnc(NC4CCC4)nc32)CC1 CHEMBL2036798 IC50 360.0 nM
CCCCNc1ncc(C(=O)NCc2ccc(-n3ccnc3)cc2)c(N[C@H]2CC[C@H](O)CC2)n1 CHEMBL3093756 IC50 360.0 nM
COc1cc2nccc(Oc3ccc(NS(=O)(=O)c4ccccc4C(F)(F)F)c(F)c3)c2cc1OC CHEMBL4545343 IC50 360.0 nM
COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(F)cc4F)c(F)c3)c2cc1OC CHEMBL178455 IC50 360.0 nM
CNc1ncc2c(-c3ccccc3)nn(C[C@H]3CC[C@@H](N)CC3)c2n1 CHEMBL2036629 IC50 370.0 nM
CCCCNc1ncc(C(=O)Nc2ccc(CN3CCOCC3)cc2)c(N[C@H]2CC[C@H](O)CC2)n1 CHEMBL3093752 IC50 370.0 nM
CCCCNc1ncc(C(=O)NC2CCCCC2)c(N[C@H]2CC[C@H](O)CC2)n1 CHEMBL3093746 IC50 370.0 nM
CCC[C@H](C)Nc1ncc2c(C3CCNC3)cn([C@H]3CC[C@H](O)CC3)c2n1 CHEMBL4851303 IC50 370.0 nM
CCC[C@H](C)Nc1ncc2c(C3CCN(C)CC3)cn([C@H]3CC[C@H](O)CC3)c2n1 CHEMBL4862062 IC50 370.0 nM
C=C(C)c1nn(C[C@H]2CC[C@H](O)CC2)c2nc(NC)ncc12 CHEMBL2036625 IC50 380.0 nM
CNc1ncc2c(-c3ccc(N4CCN(C)CC4)nc3)nn(Cc3cn(Cc4ccccc4)nn3)c2n1 CHEMBL4218369 IC50 380.0 nM
COc1cc2c(Oc3ccc(NS(=O)(=O)c4ccc(F)cc4F)cc3F)ccnc2cc1OCCCN1CCN(C)CC1 CHEMBL4458253 IC50 380.0 nM
COc1cc2c(Oc3ccc(NS(=O)(=O)c4cccc(F)c4)cc3F)ccnc2cc1OCCCN1CCN(C)CC1 CHEMBL4556669 IC50 388.0 nM
CC(CO)NC(=N)c1c(O)nsc1Nc1ccc(Nc2ccccc2)cc1 CHEMBL253116 IC50 389.0 nM
CCN(CCO)CCCOc1ccc2c(Nc3cc(CC(=O)Nc4cccc(F)c4)[nH]n3)ncnc2c1 CHEMBL215152 Kd 390.0 nM
OC1CCCCCCCNc2ncc3c(-c4ccccn4)cn(c3n2)CCCC1 CHEMBL3898397 IC50 390.0 nM
Cc1nc(C)n(-c2ccc(F)cc2)c(=O)c1C(=O)Nc1ccc(Oc2ccncc2-c2cnn(C)c2)cc1 CHEMBL4879206 IC50 395.7 nM
Cc1cc(Cl)ccc1NC(=S)NNC(=O)C(O)(c1ccccc1)c1ccccc1 CHEMBL1988173 pKi 398.11 nM
Nc1ncnc2scc(-c3ccc(NC(=O)Nc4ccccc4)cc3)c12 CHEMBL1967531 pKi 398.11 nM
Cc1cc(C)c2oc(Nc3ccc(-c4cccc(C(N)=O)c4N)cc3F)nc2c1 CHEMBL1990884 pKi 398.11 nM
Cc1cc(C)c(C)c(OCCCc2c(C(=O)O)[nH]c3c(-c4ccccc4C)cccc23)c1 CHEMBL1990821 pKi 398.11 nM
O=C(NNC(=S)Nc1ccc(Cl)cc1)C(O)(c1ccccc1)c1ccccc1 CHEMBL1966722 pKi 398.11 nM
COc1cc(C=C(C#N)c2nc3cc(C)ccc3[nH]2)c(Br)cc1O CHEMBL2000345 pKi 398.11 nM
COc1ccc(C(=O)Nc2cnc3[nH]cc(-c4ccccc4)c3c2)cc1 CHEMBL1997764 pKi 398.11 nM
O=C(Nc1cnc2[nH]cc(-c3ccccc3)c2c1)c1cccc(F)c1F CHEMBL1974416 pKi 398.11 nM
O=C(Nc1ccc(Oc2cc(NC(=O)C3CC3)ncn2)cc1)Nc1ccc(CN2CCn3ccnc3C2)c(C(F)(F)F)c1 CHEMBL4746916 pIC50 398.11 nM
CN(Cc1ccc2nccn2c1)c1nnc(-c2ccc(-c3ccccc3Cl)cc2)o1 CHEMBL4754609 pIC50 398.11 nM
CN(Cc1ccc2c(c1)CCCO2)c1nnc(-c2ccc(-c3ccccc3Cl)cc2)o1 CHEMBL4751490 pIC50 398.11 nM
Cc1cc(-c2c(C)nn(C)c2C)ccc1-c1nnc(N(C)Cc2ccc3ncc(C(=O)N(C)C)n3c2)o1 CHEMBL4862672 pIC50 398.11 nM
CCCCNc1ncc(C(=O)Nc2ccc(S(=O)(=O)N3CCOCC3)cc2)c(N[C@H]2CC[C@H](N)CC2)n1 CHEMBL3093635 IC50 400.0 nM
CNc1ncc2c(-c3ccc(N4CCNCC4)nc3)nn(Cc3cn(Cc4ccccc4)nn3)c2n1 CHEMBL4210084 IC50 400.0 nM
CCC[C@H](C)Nc1ncc2c(C3CCN(C(=O)C4CCOCC4)CC3)cn([C@H]3CC[C@H](O)CC3)c2n1 CHEMBL4847256 IC50 400.0 nM
CN(Cc1ccc2nccn2c1)c1ccc(-c2ccc(-c3ccccc3Cl)cc2)o1 CHEMBL5435571 IC50 400.0 nM
O=C1NCCCCn2cc(cn2)-c2cnc3ccc(cc3c2)CCn2nc(ccc2=O)-c2ccc1c(C(F)(F)F)c2 CHEMBL5181396 IC50 401.3 nM
CCC[C@H](C)Nc1ncc2c(-c3ccnc(C(=O)OC)c3)cn([C@H]3CC[C@H](O)CC3)c2n1 CHEMBL4284846 IC50 416.0 nM
CNC(=O)c1ccccc1Sc1ccc2c(/C=C/c3ccccn3)n[nH]c2c1 CHEMBL1289926 Kd 420.0 nM
Cc1cnc(Nc2ccc(N(C)C3CCN(C)CC3)cc2)nc1-c1ccc(F)c(Cl)c1 CHEMBL2022962 IC50 420.0 nM
CCC[C@H](C)Nc1ncc2c(C3CCN(C(C)C)CC3)cn([C@H]3CC[C@H](O)CC3)c2n1 CHEMBL4848248 IC50 420.0 nM
Cc1ccc(-c2ccc3c(ccc4sc5c(c43)NC[C@@H](C)NC5=O)n2)cn1 CHEMBL1231206 IC50 428.0 nM
C[C@@H](Oc1ccc2ncc(C3CC3C(N)=O)cc2c1)c1c(Cl)ccc(F)c1Cl CHEMBL602472 IC50 430.0 nM
CCCCNc1ncc(C(=O)NC2CCN(C(C)C)CC2)c(N[C@H]2CC[C@H](O)CC2)n1 CHEMBL3093763 IC50 430.0 nM
O[C@H]1CC[C@H](Nc2nc(NCCc3ccccc3)ncc2-c2ccccn2)CC1 CHEMBL3092781 IC50 430.0 nM
COc1cc2c(Oc3ccc(NS(=O)(=O)c4ccccc4C)cc3F)ccnc2cc1OCCCN1CCN(C)CC1 CHEMBL4555354 IC50 430.0 nM
O=C(O)c1ccc(Nc2ncc3c(n2)-c2ccc(Cl)cc2C(c2c(F)cccc2F)=NC3)cc1 CHEMBL259084 Kd 440.0 nM
Cc1cnc(Nc2ccc(CN3CCN(C)CC3)cc2)nc1-c1cccc(Cl)c1 CHEMBL2022963 IC50 440.0 nM
C[C@@H](Sc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl CHEMBL2442124 IC50 446.5 nM
Nc1ncc(-c2cc([C@H]3[C@@H]4CN(C5COC5)C[C@@H]43)n(CC3CC3)n2)cc1C(F)(F)F CHEMBL3715238 IC50 448.0 nM
CCC[C@H](C)Nc1ncc2c(C3CCN(C(=O)c4cncnc4)CC3)cn([C@H]3CC[C@H](O)CC3)c2n1 CHEMBL4877792 IC50 450.0 nM
CC(CO)/N=C(\N)c1c(O)nsc1Nc1ccc(Oc2ccccc2)cc1 CHEMBL437331 IC50 455.0 nM
CCCCNc1ncc(-c2ccc(F)cn2)c(N[C@H]2CC[C@H](O)CC2)n1 CHEMBL3092804 IC50 460.0 nM
CCC[C@H](C)Nc1ncc2c(C3CCN(S(=O)(=O)C4CCOCC4)CC3)cn([C@H]3CC[C@H](O)CC3)c2n1 CHEMBL4853524 IC50 470.0 nM
CCC[C@H](C)Nc1ncc2c(C3CCN(C(=O)c4cnccn4)CC3)cn([C@H]3CC[C@H](O)CC3)c2n1 CHEMBL4873478 IC50 470.0 nM
CCCCNc1ncc(C(=O)NC2CCNCC2)c(N[C@H]2CC[C@H](O)CC2)n1 CHEMBL3093761 IC50 480.0 nM
CCCCn1c(C)c(C(=O)Nc2ccc(Oc3ncnc4[nH]cc(-c5ccccc5)c34)c(F)c2)c(=O)c2cc(C)ccc21 CHEMBL4578200 IC50 480.0 nM
CCC[C@H](C)Nc1ncc2c(C3CCN(C(=O)c4cccnc4)CC3)cn([C@H]3CC[C@H](O)CC3)c2n1 CHEMBL4854055 IC50 500.0 nM
Cc1c(-c2cccc(OCc3ccccc3)c2)c2c(N)ncnc2n1C1CC(CN2CCCC2)C1 CHEMBL1968791 pKi 501.19 nM
COc1cccc(CNC(=O)c2cc3c(-c4ccccc4)n[nH]c3s2)c1 CHEMBL1987009 pKi 501.19 nM
NCCCn1cc(-c2cc(-c3cc4ccccc4s3)c3[nH]ncc3c2)c2nc(N)ncc21 CHEMBL592030 pKi 501.19 nM
Nc1ncnc2c1c(I)nn2C1CCC(O)CC1 CHEMBL1996791 pKi 501.19 nM
c1ccc(-c2cnc3[nH]cc(-c4ccc(-c5nnn[nH]5)cc4)c3c2)cc1 CHEMBL564697 IC50 524.0 nM
CCCCNc1ncc(C(=O)Nc2ccc(S(=O)(=O)N3CCOCC3)cc2)c(N[C@H]2CC[C@H](O)CC2)n1 CHEMBL3093753 IC50 530.0 nM
CNc1ncc2c(-c3ccc(N4CCNCC4)nc3)nn(CC3OCCO3)c2n1 CHEMBL4214476 IC50 530.0 nM
CCCn1c(C)c(C(=O)Nc2ccc(Oc3ncnc4[nH]cc(-c5ccccc5)c34)c(F)c2)c(=O)c2cc(C)ccc21 CHEMBL4458751 IC50 530.0 nM
CCCCNc1ncc(-c2ccccn2)c(N[C@H]2CC[C@H](N)CC2)n1 CHEMBL3092799 IC50 550.0 nM
CCC[C@H](C)Nc1ncc2c(C3CCN(C(=O)c4cscn4)CC3)cn([C@H]3CC[C@H](O)CC3)c2n1 CHEMBL4868941 IC50 550.0 nM
COc1cc(N2CCN(C)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2-c2n[nH]c(C)n2)n1 CHEMBL5169769 IC50 555.0 nM
CO[C@@H]1[C@H](N(C)CCOCCOCCOCCNC(=O)CCC2=[N+]3C(=Cc4c(C)cc(C)n4[B-]3(F)F)C=C2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL4576489 Kd 559.0 nM
CCCCNc1ncc(C(=O)NC2CCN(c3ncccn3)CC2)c(N[C@H]2CC[C@H](O)CC2)n1 CHEMBL3093648 IC50 560.0 nM
CCC[C@@H](C)Nc1ncc2c(-c3ccc(CN4CCN(C)CC4)cc3)cn([C@H]3CC[C@H](O)CC3)c2n1 CHEMBL4294819 IC50 560.0 nM
Cc1ccc2[nH]c(C)c(C(=O)Nc3ccc(Oc4ncnc5[nH]cc(-c6ccccc6)c45)c(F)c3)c(=O)c2c1 CHEMBL4459999 IC50 560.0 nM
CCN1CCN(Cc2ccc(NC(=O)Nc3ccc(Oc4cc(NC)ncn4)cc3)cc2C(F)(F)F)CC1 CHEMBL574738 Kd 570.0 nM
C[C@@H](Oc1ccc2ncc(/C=C/C(N)=O)cc2c1)c1c(Cl)ccc(F)c1Cl CHEMBL602471 IC50 570.0 nM
CCCCNc1ncc(C(=O)Nc2ccc(N3CCOCC3)cc2)c(N[C@H]2CC[C@H](O)CC2)n1 CHEMBL3093751 IC50 570.0 nM
CCn1nc(C#Cc2cc(C(=O)Nc3ccc(CN4CCN(C)CC4)c(C(F)(F)F)c3)ccc2C)c2c(N)ncnc21 CHEMBL3426225 IC50 578.0 nM
CCCCNc1ncc(C(=O)NC2CCOCC2)c(N[C@H]2CC[C@H](O)CC2)n1 CHEMBL3093649 IC50 580.0 nM
CCC[C@H](C)Nc1ncc2c(C3CCN(C(=O)c4ccccn4)CC3)cn([C@H]3CC[C@H](O)CC3)c2n1 CHEMBL4875352 IC50 580.0 nM
Cn1cc(-c2n[nH]c3ccc(Nc4ccccc4)cc23)cn1 CHEMBL4863898 IC50 580.0 nM
COc1cc2nccc(Oc3ccc(Nc4nn(C)cc4C(=O)NC4CC4)cc3F)c2cc1OC CHEMBL5188942 IC50 585.6 nM
Cc1cc(C(=O)N2CCC(c3cn([C@H]4CC[C@H](O)CC4)c4nc(NCC5CCCCC5)ncc34)CC2)cc(C)n1 CHEMBL4861169 IC50 590.0 nM
N#Cc1ccc(-c2cnc3[nH]cc(NC(=O)c4cccnc4)c3c2)cc1 CHEMBL516312 Kd 596.0 nM
CNc1ncc2c(-c3ccc(F)nc3)nn(CC3CCC(N)CC3)c2n1 CHEMBL2036790 IC50 610.0 nM
CCCNc1ncc(C(=O)Nc2ccc(S(=O)(=O)N3CCOCC3)cc2)c(N[C@H]2CC[C@H](O)CC2)n1 CHEMBL3093625 IC50 610.0 nM
CO[C@@H]1[C@H](N(C)C(=O)c2ccccc2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL608533 Kd 620.0 nM
OC1CCCCCCCNc2ncc3c(-c4ccc(F)cc4)cn(c3n2)CCCC1 CHEMBL3906299 IC50 620.0 nM
CNC(=O)N1CCC[C@H](c2csc(-c3ccccc3NC(=O)c3ncc[nH]3)n2)C1 CHEMBL4067646 IC50 620.0 nM
Cc1ccc2c(c1)c(=O)c(C(=O)Nc1ccc(Oc3ncnc4[nH]cc(-c5ccccc5)c34)c(F)c1)c(C)n2-c1ccccc1 CHEMBL4437303 IC50 620.0 nM
Cn1cc(-c2n[nH]c3ccc(-c4ccccc4)cc23)cn1 CHEMBL4873207 IC50 620.0 nM
COc1ccc2c(c1)C(=Cc1c[nH]cn1)C(=O)N2 CHEMBL2002649 pKi 630.96 nM
NC(=O)c1ccc(-c2c[nH]c3nccc(Cl)c23)cc1 CHEMBL1982711 pKi 630.96 nM
O=C(Nc1cnc2[nH]cc(-c3ccccc3)c2c1)c1ccc(Cl)cc1 CHEMBL1998829 pKi 630.96 nM
c1cc2cc(-c3ccc4cn[nH]c4c3)cnc2[nH]1 CHEMBL1976134 pKi 630.96 nM
NC(=O)c1c(OCc2c(F)cc(Br)cc2F)nsc1NC(=O)NCCCCN1CCCC1 CHEMBL253969 pKi 630.96 nM
Cc1ccccc1NC(=O)Nc1ccc2c(c1)CCc1sc3ncnc(N)c3c1-2 CHEMBL1982135 pKi 630.96 nM
Nc1ncc(C=CC(=O)NCCCn2ccnc2)c2scc(-c3ccc(Br)cc3)c12 CHEMBL1994938 pKi 630.96 nM
CC(C)OC1=NNC(=O)C1=Cc1c[nH]c2ccccc12 CHEMBL1989029 pKi 630.96 nM
Cc1nn(C)c(C)c1-c1cccc2c(CCCOc3cccc4ccccc34)c(C(=O)O)[nH]c12 CHEMBL1984039 pKi 630.96 nM
Cc1ccccc1-c1ccc(-c2nnc(N(C)Cc3ccc4nccn4c3)o2)cc1 CHEMBL4863682 pIC50 630.96 nM
COc1cc2c(Oc3ccc(NC(=O)NN4C(=O)CSC4c4c(F)cccc4F)cc3)ccnc2cc1OC1CCN(C(=O)NC(C)C)CC1 CHEMBL4781937 IC50 632.0 nM
COc1cc2c(Oc3ccc(NS(=O)(=O)c4cc(F)ccc4F)cc3F)ccnc2cc1OCCCN CHEMBL4460986 IC50 636.0 nM
OC1CCCCCCCNc2ncc3c(C4CCOCC4)cn(c3n2)CCCC1 CHEMBL3923652 IC50 640.0 nM
CCCCCNc1ncc(-c2ccccn2)c(N[C@H]2CC[C@H](O)CC2)n1 CHEMBL3092775 IC50 650.0 nM
COCCNc1ncc2c(-c3ccccc3)nn(CC3CCC(N)CC3)c2n1 CHEMBL2036799 IC50 660.0 nM
Clc1cc2[nH]nc(-c3cnn(-c4ccccc4)c3)c2cc1N[C@@H]1CCNC1 CHEMBL4848476 IC50 668.0 nM
CCC[C@H](C)Nc1ncc2c(C3CCN(C(=O)c4ncccn4)CC3)cn([C@H]3CC[C@H](O)CC3)c2n1 CHEMBL4846907 IC50 670.0 nM
CCCCNc1ncc(-c2ccccn2)c(NC[C@H]2CC[C@H](N)CC2)n1 CHEMBL3092787 IC50 680.0 nM
CCC[C@H](C)Nc1ncc2c(C3CCN(C(=O)c4ccc(N(C)C)cc4)CC3)cn([C@H]3CC[C@H](O)CC3)c2n1 CHEMBL4861342 IC50 680.0 nM
CCC[C@H](C)Nc1ncc2c(C3CCN(C(=O)c4cccnn4)CC3)cn([C@H]3CC[C@H](O)CC3)c2n1 CHEMBL4845859 IC50 680.0 nM
Fc1ccc(-n2cc(-c3n[nH]c4cc(Cl)c(N[C@@H]5CCNC5)cc34)cn2)cc1 CHEMBL4863561 IC50 684.0 nM
CNc1ncc2c(-c3ccccc3OC)nn(CC3CCC(N)CC3)c2n1 CHEMBL2036632 IC50 690.0 nM
CCC[C@H](C)Nc1ncc2c(C3CCN(S(C)(=O)=O)CC3)cn([C@H]3CC[C@H](O)CC3)c2n1 CHEMBL4854016 IC50 690.0 nM
N#Cc1ccc(-n2cc(-c3n[nH]c4cc(Cl)c(N[C@@H]5CCNC5)cc34)cn2)cc1 CHEMBL4854580 IC50 700.0 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(Nc3ncnc4c3OCCCN4)cc2)no1 CHEMBL4793380 IC50 708.0 nM
Cc1cnc(Nc2ccc(CN3CCN(C)CC3)cc2)nc1-c1ccc(F)c(Cl)c1 CHEMBL2022575 IC50 730.0 nM
CNc1ncc2c(-c3cccnc3)nn(CC3CCC(N)CC3)c2n1 CHEMBL2036789 IC50 750.0 nM
CNc1ncc2c(-c3ccc(N4CCN(C(=O)C(C)(C)C)CC4)nc3)nn(Cc3cn(Cc4ccccc4)nn3)c2n1 CHEMBL4207004 IC50 760.0 nM
CCNc1ncc(C(=O)Nc2ccc(S(=O)(=O)N3CCOCC3)cc2)c(N[C@H]2CC[C@H](O)CC2)n1 CHEMBL3093647 IC50 780.0 nM
CNc1ncc2c(-c3ccc(N4CCNCC4)nc3)nn(Cc3cn(-c4ccsc4C(=O)OC)nn3)c2n1 CHEMBL4205191 IC50 780.0 nM
CCCCNc1ncc(C(=O)NCc2ccc(F)cc2)c(N[C@H]2CC[C@H](O)CC2)n1 CHEMBL3093754 IC50 790.0 nM
COc1cc(N2CCN(C(C)=O)CC2)ccc1Nc1ncc(C(F)(F)F)c(N2Cc3cccc(N(C)S(C)(=O)=O)c3C2)n1 CHEMBL4546231 IC50 790.0 nM
COc1cccc(C(=O)Nc2cnc3[nH]cc(-c4ccccc4)c3c2)c1 CHEMBL1982924 pKi 794.33 nM
CCn1c(C)c(-c2ccnc(Nc3cccc(OC)c3)n2)sc1=O CHEMBL1986263 pKi 794.33 nM
COc1cc(C=C(C#N)c2nc3ccccc3[nH]2)c(Br)cc1O CHEMBL1994241 pKi 794.33 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4c[nH]c5ccccc45)c3)cc12 CHEMBL1970903 pKi 794.33 nM
Nc1ncnc2scc(C(=O)Nc3ccc(NC(=O)Nc4ccccc4)cc3)c12 CHEMBL1988594 pKi 794.33 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4cccc(OC(F)(F)F)c4)c3)cc12 CHEMBL1965836 pKi 794.33 nM
CC1=NN(c2ccc(C(=O)O)cc2)C(=O)C1=Cc1c(C)c(C#N)c2nc3ccccc3n2c1O CHEMBL2006836 pKi 794.33 nM
O=C(Nc1cnccn1)Nc1ccnc2ccc(C(F)(F)F)cc12 CHEMBL1976455 pKi 794.33 nM
Oc1ccc(-c2n[nH]c(Nc3cccc(Cl)c3)c2-c2ccc(O)cc2)cc1 CHEMBL1985092 pKi 794.33 nM
CNc1nc(OC2CCCC2)nc2c1ncn2Cc1c(F)cccc1F CHEMBL4758206 pIC50 794.33 nM
COc1cc(-c2c(C)nn(C)c2C)ccc1-c1nnc(N(C)Cc2ccc3nccn3c2)o1 CHEMBL4872116 pIC50 794.33 nM
COc1cc2c(Oc3ccc(NS(=O)(=O)c4ccccc4C(F)(F)F)cc3F)ccnc2cc1OCC(=O)N(C)C CHEMBL4565101 IC50 796.0 nM
OC1CCCCCCCNc2ncc3c(-c4ccccc4)cn(c3n2)CCCC1 CHEMBL3955697 IC50 810.0 nM
CCCCNc1ncc(-c2ccccn2)c(Nc2ccc(N)cc2)n1 CHEMBL3092801 IC50 830.0 nM
COc1cc2nccc(Oc3ccc(NS(=O)(=O)c4cc(F)ccc4F)c(F)c3)c2cc1OC CHEMBL4517444 IC50 840.0 nM
Cn1cc(-c2n[nH]c3cc(Cl)c(Br)cc23)cn1 CHEMBL4863727 IC50 850.0 nM
CCCCNc1ncc(C(=O)Nc2ccc(OC)cc2)c(N[C@H]2CC[C@H](O)CC2)n1 CHEMBL3093748 IC50 880.0 nM
COc1ccc(-n2cc(-c3n[nH]c4cc(Cl)c(N[C@H]5CNCC56CC6)cc34)cn2)cc1 CHEMBL4871278 IC50 883.0 nM
CCc1ccc2c(c1)c(=O)c(C(=O)Nc1ccc(Oc3ccnc(N)c3)c(F)c1)c(C)n2C CHEMBL4444198 IC50 888.0 nM
COc1cc(Nc2ncc(C(F)(F)F)c(N3Cc4cccc(N(C)S(C)(=O)=O)c4C3)n2)cc(C(F)(F)F)c1 CHEMBL4441802 IC50 890.0 nM
O=C(O)c1cccc(-c2c[nH]c3ncc(-c4ccccc4)cc23)c1 CHEMBL4102305 IC50 896.0 nM
COc1ccccc1-c1cn2c3nc(ncc13)NCCCCCCCC(O)CCCC2 CHEMBL3943243 IC50 910.0 nM
CN1CCN(CCCOc2ccc3nccc(Oc4ccc(NS(=O)(=O)c5ccccc5C(F)(F)F)cc4F)c3c2)CC1 CHEMBL4584711 IC50 910.0 nM
CCOc1cc2ncc(C#N)c(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)/C=C/CN(C)C CHEMBL607707 Kd 920.0 nM
COc1cccc(-c2cn3c4nc(ncc24)NCCCCCCCC(O)CCCC3)c1 CHEMBL3915275 IC50 920.0 nM
Nc1nc(Nc2ccc(CNC(=O)CCCCCCCNc3cccc4c3CN(C3CCC(=O)NC3=O)C4=O)cc2)nn1-c1ccc(-c2ccccc2)nn1 CHEMBL5187439 IC50 920.0 nM
CCCCNc1ncc(-c2cc(CN3CCOCC3)ccn2)c(N[C@H]2CC[C@H](O)CC2)n1 CHEMBL3092788 IC50 930.0 nM
Cn1cc(-c2n[nH]c3cc(Br)ccc23)cn1 CHEMBL4875335 IC50 950.0 nM
O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12 CHEMBL50 IC50 960.0 nM
Cc1cc(C(=O)N2CCC(c3cn([C@H]4CC[C@H](O)CC4)c4nc(N[C@@H](C)c5ccccc5)ncc34)CC2)cc(C)n1 CHEMBL4875531 IC50 990.0 nM