CC1(C)C(N)=N[C@](C)(c2cc(NC(=O)c3ccc(C#N)cn3)ccc2F)CS1(=O)=O CHEMBL3969403 IC50 0.0002 nM
CC1(C)C(N)=N[C@](C)(c2cc(NC(=O)c3ccc(Cl)cn3)ccc2F)CS1(=O)=O CHEMBL3261078 IC50 0.0009 nM
COc1cnc(C(=O)Nc2ccc(F)c([C@]3(C)CS(=O)(=O)C(C)(C)C(N)=N3)c2)cn1 CHEMBL3937515 IC50 0.0009 nM
C[C@@]1(c2cc(NC(=O)c3ccc(C#N)cn3)ccc2F)CS(=O)(=O)C2(CCCC2)C(N)=N1 CHEMBL3949213 IC50 0.001 nM
CC1(C)C(N)=N[C@](C)(c2cc(NC(=O)c3cnc(C(F)F)cn3)ccc2F)CS1(=O)=O CHEMBL3955051 IC50 0.0018 nM
C[C@@]1(c2cc(NC(=O)c3ccc(OC(F)F)cn3)ccc2F)CS(=O)(=O)CC(N)=N1 CHEMBL3936264 IC50 0.0057 nM
NC1=N[C@@]2(c3cc(CNCC(F)(F)F)c(F)cc3F)CO[C@@H](CF)C[C@H]2CS1 CHEMBL3673194 IC50 0.006 nM
C[C@@]1(c2cc(NC(=O)c3ccc(Cl)cn3)ccc2F)CS(=O)(=O)CC(N)=N1 CHEMBL3958332 IC50 0.0061 nM
C[C@@]1(c2cc(NC(=O)c3ccc(C#N)cn3)ccc2F)CS(=O)(=O)CC(N)=N1 CHEMBL3930841 IC50 0.0082 nM
C[C@@]1(c2cc(NC(=O)c3ccc(C#N)cn3)ccc2F)CSCC(N)=N1 CHEMBL3982593 IC50 0.011 nM
COc1ccc(C(=O)Nc2csc([C@]34CO[C@@H](C)C[C@H]3CSC(N)=N4)n2)nc1 CHEMBL3922902 IC50 0.014 nM
CC(C)CNC(=O)[C@@H](NC[C@H](Cc1ccccc1)NC(=O)c1cc(C(=O)N[C@H](C)c2ccccc2)cc(N(C)S(C)(=O)=O)c1)[C@H](C)O CHEMBL2179131 Ki 0.017 nM
C[C@@H]1C[C@@](C)(c2cc(CNC3(C(F)(F)F)CC3)c(F)cc2F)N=C(N)S1 CHEMBL4088234 IC50 0.024 nM
CC#Cc1cncc(-c2ccc3c(c2)C2(C=C(F)C(N)=N2)[C@]2(CC[C@H](OC)CC2)C3)c1 CHEMBL2408786 IC50 0.031 nM
COc1cccc(NC(=O)c2cnc([C@]34CO[C@@H](C)C[C@H]3CSC(N)=N4)s2)n1 CHEMBL4212046 IC50 0.033 nM
COc1ccc(C(=O)Nc2csc([C@]34CO[C@@H](C)C[C@H]3CSC(N)=N4)n2)cc1 CHEMBL4217023 IC50 0.034 nM
CCC[C@H](O)[C@H](NC[C@H](Cc1ccccc1)NC(=O)c1cc2c3c(c1)c(CC)cn3CC(C)(C)S(=O)(=O)N2C)C(=O)NCC(C)C CHEMBL2179138 Ki 0.036 nM
Cc1cc(C#N)cnc1C(=O)Nc1ccc(F)c([C@@]2(C)N=C(N)C(C)(C)[S@@]3(=O)=NCC[C@@H]23)c1 CHEMBL4561849 IC50 0.09 nM
CC#CCOc1cnc(C(=O)Nc2ccc(F)c([C@@]3(C)N=C(N)OC[C@]3(C)F)c2)cn1 CHEMBL3680900 IC50 0.1 nM
COc1cccc(NC(=O)c2cnc([C@]34CO[C@@H](C)C[C@H]3CSC(N)=N4)s2)c1 CHEMBL4203860 IC50 0.11 nM
Cc1nc(COC(=O)N[C@@H](CS(C)(=O)=O)C(=O)N[C@@H](CC(C)C)[C@@H](O)C[C@@H](C)C(=O)N[C@H](C(=O)NC(C)(C)C)C(C)C)c(C)o1 CHEMBL254740 Ki 0.12 nM
Cc1nc(COC(=O)N[C@@H](CS(C)(=O)=O)C(=O)N[C@@H](CC(C)C)[C@@H](O)C[C@@H](C)C(=O)N[C@H](C(=O)NCC(C)C)C(C)C)c(C)o1 CHEMBL449300 Ki 0.12 nM
C[C@@]1(c2cc(NC(=O)c3ccc(C#N)cn3)ccc2F)C=CSC(N)=N1 CHEMBL3916243 Ki 0.13 nM
CC(C)c1cccc(CNC[C@@H](O)[C@@H]2COC/C=C/C[C@H](c3ccccc3)NC(=O)c3cc(cc(N(C)S(C)(=O)=O)c3)C(=O)N2)c1 CHEMBL2047041 IC50 0.15 nM
CCn1cc([C@]2(c3cccc(NC(=O)c4ccc(Cl)cn4)c3)N=C(N)c3c(F)cccc32)cc(C)c1=O CHEMBL2177305 IC50 0.15 nM
CC(F)(F)[C@H]1OC[C@]2(c3cc(NC(=O)c4ccc(C#N)cn4)ccc3F)N=C(N)SC[C@H]12 CHEMBL4564324 IC50 0.157 nM
CC#Cc1cncc(-c2cccc([C@@]3(c4cc(C)c(=O)n(CC)c4)N=C(N)c4c(F)cccc43)c2)c1 CHEMBL2152903 IC50 0.16 nM
CC1(C)Oc2ccc(NC(=O)c3ccc(Cl)cn3)cc2[C@@]2(COC(N)=N2)C12CC2 CHEMBL3650848 IC50 0.16 nM
CCCCS(=O)(=O)C[C@@H](NC(=O)c1cnccn1)C(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)CNCc1cccc(CC)c1 CHEMBL409875 EC50 0.2 nM
CN1C(=O)C2(N=C1N)c1cc(-c3cccnc3F)ccc1Oc1c(F)cc(-c3ccnc(F)c3)cc12 CHEMBL3260839 IC50 0.2 nM
CC#Cc1cncc(-c2ccc3c(c2)[C@@]2(N=C(C)C(N)=N2)C2(CCC(OC)CC2)C3)c1 CHEMBL3349234 IC50 0.2 nM
NC1=N[C@@]2(CO1)c1cc(-c3cccnc3F)ccc1Oc1c2cc(C2=COCCC2)nc1F CHEMBL3394218 IC50 0.2 nM
NC1=N[C@@]2(CO1)c1cc(-c3cccnc3F)ccc1Oc1c2cc(N2CCC(F)(F)C2)nc1F CHEMBL3394226 IC50 0.2 nM
NC1=N[C@@]2(CO1)c1cc(-c3cccnc3F)ccc1Oc1c2cc(N2CC[C@@H](F)C2)nc1F CHEMBL3394227 IC50 0.2 nM
CC#CCOc1cnc(C(=O)Nc2ccc(F)c([C@]3(C)C[S@@]4(=O)=NCCCCN4C(N)=N3)c2)cn1 CHEMBL3741617 IC50 0.2 nM
CN1C(=O)[C@]2(N=C1N)c1cc(-c3cccnc3F)ccc1Oc1c(F)cc(-c3ccnc(F)c3)cc12 CHEMBL3695737 IC50 0.2 nM
Cc1cc(C#N)cnc1C(=O)Nc1ccc(F)c([C@]2(C)CS3(=O)=NCCCCC3(C)C(N)=N2)c1 CHEMBL4588608 IC50 0.2 nM
C#CCOc1cnc(C(=O)Nc2cc(F)c(F)c([C@@]3(C)N=C(N)S[C@@]4(CF)C[C@H]43)c2)cn1 CHEMBL4437161 IC50 0.2 nM
C#CCOc1cnc(C(=O)Nc2cc(F)c(F)c([C@@]3(C)N=C(N)S[C@@]4(C(F)F)C[C@@H]34)c2)cn1 CHEMBL4577527 IC50 0.2 nM
CCS(=O)(=O)[C@]1(C)CC[C@@](CF)(c2cc(NC(=O)c3cc4c(cn3)OC(F)(F)O4)ccc2F)N=C1N CHEMBL5092328 Ki 0.21 nM
COc1cc(/C=C/c2nnc(-c3ccc(OC(F)(F)F)cc3)o2)ccc1O CHEMBL5197518 IC50 0.211 nM
Cc1csc(C[C@H](C)C(=O)N[C@@H](CNC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(C)C)[C@@H](O)C[C@@H](C)C(=O)N[C@H](C(=O)NCC(C)C)C(C)C)n1 CHEMBL3352906 Ki 0.25 nM
CC1(c2cc(NC(=O)c3ccc(C#N)cn3)ccc2F)Cc2c(F)cncc2C(N)=N1 CHEMBL4861687 IC50 0.25 nM
COc1cc(/C=C/c2nnc(-c3ccc(C(F)(F)F)cc3)o2)ccc1O CHEMBL5190569 IC50 0.255 nM
CC#Cc1cncc(-c2ccc3c(c2)C2(N=C(C)C(N)=N2)[C@]2(CC[C@H](OC)CC2)C3)c1 CHEMBL2152914 IC50 0.28 nM
CC(C)C[C@H](NC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)C(O)CN[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(C)C CHEMBL363255 Ki 0.3 nM
CC(C)C[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(C)C CHEMBL2372119 Ki 0.3 nM
Cc1cc(C)n(COC(=O)N[C@@H](CS(C)(=O)=O)C(=O)N[C@@H](CC(C)C)[C@@H](O)C[C@@H](C)C(=O)N[C@H](C(=O)NCC(C)C)C(C)C)n1 CHEMBL448008 Ki 0.3 nM
CC(C)C[C@H](NC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)[C@@H](O)C[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(C)C CHEMBL390456 Ki 0.3 nM
CN1C(=O)C2(N=C1N)c1cc(-c3cccnc3)ccc1Oc1ccc(-c3cccnc3)cc12 CHEMBL3260838 IC50 0.3 nM
NC1=N[C@@]2(CO1)c1cc(-c3cccnc3F)ccc1Oc1c(F)cc(C3=CCOCC3)cc12 CHEMBL3354718 IC50 0.3 nM
NC1=N[C@@]2(CO1)c1cc(-c3cccnc3F)ccc1Oc1c2cc(-c2cccnc2)nc1F CHEMBL3394211 IC50 0.3 nM
NC1=N[C@@]2(CO1)c1cc(-c3cccnc3F)ccc1Oc1c2cc(-c2ccc(F)nc2)nc1F CHEMBL3394216 IC50 0.3 nM
NC1=N[C@@]2(CO1)c1cc(-c3ncccc3F)ccc1Oc1c2cc(C2=CCCOC2)nc1F CHEMBL3394220 IC50 0.3 nM
NC1=N[C@@]2(CO1)c1cc(-c3cccnc3F)ccc1Oc1c2cc(C2=CCOCC2)nc1F CHEMBL3394221 IC50 0.3 nM
NC1=N[C@@]2(CO1)c1cc(-c3cccnc3F)ccc1Oc1c2cc(N2CCOCC2)nc1F CHEMBL3394224 IC50 0.3 nM
NC1=N[C@@]2(CO1)c1cc(-c3cccnc3F)ccc1Oc1c2cc(N2CCC(F)(F)CC2)nc1F CHEMBL3394225 IC50 0.3 nM
Cc1cc(-c2cc3c(c(F)n2)Oc2ccc(-c4cccnc4F)cc2[C@@]32COC(N)=N2)on1 CHEMBL3394228 IC50 0.3 nM
CN1C(=O)[C@]2(N=C1N)c1cc(-c3cccc(Cl)c3)ccc1Oc1c(F)cc(C3=CCOCC3)cc12 CHEMBL3695734 IC50 0.3 nM
NC1=N[C@@]2(c3cc(-c4cccnc4F)ccc3Oc3c(F)cc(-c4ccnc(F)c4)cc32)c2nccn21 CHEMBL3677271 IC50 0.3 nM
C#CCOc1cnc(C(=O)Nc2cc(F)c(F)c([C@@]3(C)N=C(N)S[C@@]4(C(=O)N(C)C)C[C@H]43)c2)cn1 CHEMBL4472708 IC50 0.3 nM
CC#Cc1cncc(-c2ccc3c(c2)[C@@]2(COC(N)=N2)c2cc(C4=CCOCC4)ncc2O3)c1 CHEMBL4284110 IC50 0.31 nM
CC(C)C[C@H](NC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)[C@@H](O)C[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)NC(Cc1ccccc1)C(=O)O)C(C)C CHEMBL264379 Ki 0.32 nM
CC(C)C[C@H](NC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)[C@@H](O)C[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)C[C@@H](Cc1ccccc1)C(=O)O)C(C)C CHEMBL183214 Ki 0.32 nM
CO[C@H](C[C@H](O)[C@H](COc1cc(F)cc(F)c1)NC(=O)c1cc(C(=O)N[C@H](C)c2ccccc2)cc(N(C)S(C)(=O)=O)c1)C(=O)N[C@H](C(=O)NCc1ccccc1)C(C)C CHEMBL573106 IC50 0.32 nM
C[C@H]1SC(N)=N[C@](C)(c2cc(NC(=O)c3cnc(OCF)cn3)ccc2F)[C@H]1F CHEMBL4557670 Ki 0.34 nM
[C-]#[N+]c1ccc(C(=O)Nc2ccc(F)c([C@]34CN(c5ncc(F)cn5)C[C@H]3CSC(N)=N4)c2)nc1 CHEMBL3667414 IC50 0.358 nM
CC1(c2cc(NC(=O)c3ccc(C#N)cn3)ccc2F)Cc2c(ccnc2F)C(N)=N1 CHEMBL4865090 IC50 0.36 nM
CC#Cc1cncc(-c2cccc([C@@]3(c4cc(C)c(=O)n(CC)c4)N=C(N)c4c(F)cc(F)cc43)c2)c1 CHEMBL2177303 IC50 0.38 nM
CC(F)(F)[C@H]1OC[C@]2(c3cc(NC(=O)c4cnc(-n5cncn5)cn4)ccc3F)N=C(N)SC[C@H]12 CHEMBL4473955 IC50 0.385 nM
C[C@]1(c2cc(NC(=O)c3ccc(C#N)cn3)ccc2F)N=C(N)O[C@H]2[C@@H]1OCC2(F)F CHEMBL4453037 IC50 0.391 nM
COCCN(C[C@H]1C[C@@H]1C)c1cc(-c2nnc([C@](C)(N)Cc3ccccc3)o2)c(Cl)c(N(C)S(C)(=O)=O)n1 CHEMBL1088070 IP 0.4 nM
CCC[C@H](O)[C@H](NC[C@H](Cc1ccccc1)NC(=O)c1cc2c3c(c1)c(CC)cn3CCS(=O)(=O)N2C)C(=O)NCC(C)C CHEMBL2179137 Ki 0.4 nM
COc1cccc(CNC[C@@H](O)[C@H](Cc2ccccc2)NC(=O)c2cc(C(=O)N[C@H](C)c3ccccc3)cc(N(C)S(C)(=O)=O)c2)c1 CHEMBL403268 IC50 0.4 nM
CC1(COc2cc(F)c3c(c2)[C@]2(COC(N)=N2)c2cc(-c4cccnc4F)ccc2O3)COC1 CHEMBL3354715 IC50 0.4 nM
CC(C)(C)COc1cnc2c(c1)[C@]1(COC(N)=N1)c1cc(-c3cccnc3F)ccc1O2 CHEMBL3359749 IC50 0.4 nM
NC1=N[C@@]2(CO1)c1cc(-c3cccnc3F)ccc1Oc1c2cc(-c2ccncc2)nc1F CHEMBL3394212 IC50 0.4 nM
Cc1ccc(-c2cc3c(c(F)n2)Oc2ccc(-c4cccnc4F)cc2[C@@]32COC(N)=N2)cn1 CHEMBL3394213 IC50 0.4 nM
NC1=N[C@@]2(CO1)c1cc(-c3cccnc3F)ccc1Oc1c2cc(-c2ccnc(F)c2)nc1F CHEMBL3394217 IC50 0.4 nM
NC1=N[C@@]2(CO1)c1cc(-c3cccnc3F)ccc1Oc1c2cc(C2=CCCCO2)nc1F CHEMBL3394219 IC50 0.4 nM
C[C@]1(F)COC(N)=N[C@]1(C)c1cc(NC(=O)c2ccc(C#N)cn2)ccc1F CHEMBL3680889 IC50 0.4 nM
C[C@]1(c2cc(NC(=O)c3ccc(Cl)cn3)ccc2F)N=C(N)OC[C@@H]1F CHEMBL3680854 IC50 0.4 nM
CC(C)(C)CCNC(=O)CCc1cc2cc(-c3ccccc3CCc3ccc(NC(=O)c4ccc(F)cc4)cn3)ccc2nc1N CHEMBL3809870 Kd 0.4 nM
NC1=N[C@]2(c3cc(-c4cccnc4F)ccc3Oc3c(F)cc(C4=CCCOC4)cc32)c2nccn21 CHEMBL3677273 IC50 0.4 nM
Cc1ccc(-c2cc(F)c3c(c2)[C@@]2(N=C(N)n4ccnc42)c2cc(-c4cccnc4F)ccc2O3)cc1 CHEMBL3677275 IC50 0.4 nM
CC#CCOc1cnc(C(=O)Nc2ccc3c(c2)C2(CCOC(N)=N2)c2cc(Cl)nc(F)c2O3)cn1 CHEMBL3968517 IC50 0.4 nM
COc1ccc(C(=O)Nc2ccc3c(c2)C2(CCSC(N)=N2)c2cc(-c4ccnc(F)c4)nc(F)c2O3)nc1 CHEMBL3970753 IC50 0.4 nM
CN1C(N)=N[C@](C)(c2cc(NC(=O)c3ccc(F)cn3)ccc2F)CS1(=O)=O CHEMBL3301601 IC50 0.4 nM
CNC(=O)[C@]12C[C@H]1[C@@](C)(c1cc(NC(=O)c3ccc(Cl)cn3)cc(F)c1F)N=C(N)S2 CHEMBL4475533 IC50 0.4 nM
CN(C)C(=O)[C@]12C[C@H]1[C@@](C)(c1cc(NC(=O)c3ccc(Cl)cn3)cc(F)c1F)N=C(N)S2 CHEMBL4473740 IC50 0.4 nM
C#CCOc1cnc(C(=O)Nc2cc(F)c(F)c([C@@]3(C)N=C(N)S[C@@]4(COC)C[C@H]43)c2)cn1 CHEMBL4560579 IC50 0.4 nM
C#CCOc1cnc(C(=O)Nc2cc(F)c(F)c([C@@]3(C)N=C(N)S[C@@]4(COC)CC43)c2)cn1 CHEMBL5093088 IC50 0.4 nM
C[C@@]1(c2cc(NC(=O)c3ccc(C#N)cn3)ccc2F)Cc2c(ccnc2F)C(N)=N1 CHEMBL4868952 IC50 0.41 nM
CC#Cc1cncc(-c2ccc3c(c2)[C@@]2(COC(N)=N2)c2cc(-c4ccnc(F)c4)ncc2O3)c1 CHEMBL4287483 IC50 0.43 nM
[C-]#[N+]c1ccc(C(=O)Nc2cccc([C@]34CN(c5ncc(F)cn5)C[C@H]3CSC(N)=N4)c2)nc1 CHEMBL3667412 IC50 0.45 nM
CC#Cc1cncc(-c2ccc3c(c2)[C@@]2(COC(N)=N2)c2cc(C4=CCCOC4)ncc2O3)c1 CHEMBL4276834 IC50 0.46 nM
CCC[C@H](O)[C@H](NC[C@H](Cc1ccccc1)NC(=O)c1cc2c3c(c1)c(CC)cn3CC1(CC1)S(=O)(=O)N2C)C(=O)NC(C)C CHEMBL2179140 Ki 0.47 nM
COc1cc(/C=C/c2nnc(-c3ccc(F)cc3)o2)ccc1O CHEMBL5269238 IC50 0.479 nM
NC1=N[C@@]2(c3cccc(NC(=O)c4cnc(CO)cn4)c3)CN(c3ncc(F)cn3)C[C@H]2CS1 CHEMBL3667409 IC50 0.482 nM
COc1cnc(C(=O)Nc2cccc([C@]34CN(c5ncc(F)cn5)C[C@H]3CSC(N)=N4)c2)cn1 CHEMBL4446406 IC50 0.482 nM
NC1=N[C@@]2(COCC1)c1cc(-c3cccnc3F)ccc1Oc1cnc(-c3ccnc(F)c3)cc12 CHEMBL2152910 IC50 0.5 nM
CC(C)(C)COc1cc(F)c2c(c1)[C@]1(COCCC(N)=N1)c1cc(-c3cccnc3F)ccc1O2 CHEMBL2152911 IC50 0.5 nM
CC(C)(C)COc1ccc2c(c1)[C@]1(COC(N)=N1)c1cc(-c3c(F)ccnc3F)ccc1O2 CHEMBL3354710 IC50 0.5 nM
NC1=N[C@@]2(CO1)c1cc(-c3cccnc3F)ccc1Oc1cnc(C3=CCCOC3)cc12 CHEMBL3394041 IC50 0.5 nM
NC1=N[C@@]2(CO1)c1cc(-c3cccnc3F)ccc1Oc1cnc(N3CC[C@@H](F)C3)cc12 CHEMBL3394051 IC50 0.5 nM
CC#Cc1cncc(-c2ccc3c(c2)[C@]2(N=C(N)N(C)C2=O)c2cc(C4=CCOCC4)cc(F)c2O3)c1 CHEMBL3695730 IC50 0.5 nM
C#CCOc1cnc(C(=O)Nc2ccc(F)c([C@]3(C)C[C@@H](C(F)(F)F)OC(N)=N3)c2)cn1 CHEMBL3939374 IC50 0.5 nM
CN1C(=N)N[C@](C)(c2sc(-c3cc(F)cc(-c4nnco4)c3)cc2Cl)CS1(=O)=O CHEMBL3942915 Ki 0.5 nM
NC1=N[C@@]2(c3cc(NC(=O)c4ccc(F)cn4)ccc3F)CN(c3ncc(F)cn3)C[C@H]2CS1 CHEMBL3667410 IC50 0.554 nM
CO[C@H]1CC[C@]2(CC1)Cc1ccc(OCC(C)C)cc1C21N=C(C)C(N)=N1 CHEMBL2152917 IC50 0.56 nM
NC1=N[C@@]2(c3cc(NC(=O)c4cnc(CO)cn4)ccc3F)CN(c3ncc(F)cn3)C[C@H]2CS1 CHEMBL3667411 IC50 0.569 nM
NC1=N[C@@]2(CO1)c1cc(NC(=O)c3ccc(Cl)cn3)ccc1Oc1cnc(C3CCOCC3)cc12 CHEMBL4286331 IC50 0.57 nM
C[C@]1(c2cc(NC(=O)c3ccc(C#N)cn3)ccc2F)N=C(N)O[C@H](CF)[C@@H]1F CHEMBL4226077 IC50 0.58 nM
NC1=N[C@@]2(CO1)c1cc(-c3cncc(C#CCO)c3)ccc1Oc1cnc(C3=CCOCC3)cc12 CHEMBL4290822 IC50 0.58 nM
CO[C@H]1CC[C@]2(CC1)Cc1ccc(-c3cc(Cl)c(F)c(C#N)c3)cc1C21N=C(C)C(N)=N1 CHEMBL2152921 IC50 0.59 nM
CN=[S@@]1(=O)C[C@@](C)(c2cc(NC(=O)c3ncc(C#N)cc3C)ccc2F)N=C(N)N1CC(F)(F)F CHEMBL4740873 IC50 0.59 nM
CC(C)C[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CCC(=O)O)C(C)C)[C@@H](O)C[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)O CHEMBL78946 IC50 0.6 nM
CCCCS(=O)(=O)C[C@@H](NC(=O)OCc1cccnc1)C(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)CNCc1cccc(CC)c1 CHEMBL409949 EC50 0.6 nM
CC(C)(C)COc1cnc2c(c1)[C@]1(COC(N)=N1)c1cc(-c3cccnc3)ccc1O2 CHEMBL3359748 IC50 0.6 nM
NC1=N[C@@]2(CO1)c1cc(-c3cccnc3F)ccc1Oc1cnc(N3CCC(F)(F)C3)cc12 CHEMBL3394049 IC50 0.6 nM
C[C@]1(c2cc(NC(=O)c3ncc(Cl)cc3Cl)ccc2F)N=C(N)OC[C@@H]1F CHEMBL3680855 IC50 0.6 nM
NC1=NC2(CO1)c1cc(NC(=O)c3ccc(Cl)cn3)ccc1Oc1ccc(C3=CCCOC3)cc12 CHEMBL3809662 Kd 0.6 nM
CN1C(=O)C[C@]2(N=C1N)c1cc(-c3cccnc3F)ccc1Oc1c2cc(C2=CC(C)(C)OCC2)nc1F CHEMBL3695751 IC50 0.6 nM
NC1=N[C@@]2(c3cc(-c4cccnc4F)ccc3Oc3c(F)cc([N+]4=CCOCC4)cc32)c2nccn21 CHEMBL4109073 IC50 0.6 nM
COC1CCC2(CC1)Cc1ccc(-c3ccc(F)c(Cl)c3)cc1C21N=C(N)N(C)C1=O CHEMBL3968202 IC50 0.6 nM
N#Cc1ccc(C(=O)Nc2ccc3c(c2)C2(CCOC(N)=N2)c2cc(-c4cncc(F)c4)nc(F)c2O3)nc1 CHEMBL3959106 IC50 0.6 nM
NC1=NC2(CCO1)c1cc(NC(=O)c3cnc(Cl)cn3)ccc1Oc1c2cc(-c2cncc(F)c2)nc1F CHEMBL3949245 IC50 0.6 nM
Cc1nc(C(=O)Nc2ccc3c(c2)C2(CCOC(N)=N2)c2cc(-c4cncc(F)c4)nc(F)c2O3)cs1 CHEMBL3945386 IC50 0.6 nM
N#Cc1ccc(C(=O)Nc2ccc3c(c2)C2(CCOC(N)=N2)c2cc(-c4ccnc(F)c4)nc(F)c2O3)nc1 CHEMBL3955960 IC50 0.6 nM
NC1=N[C@@](c2cccc(-c3cncnc3)c2)(c2ccnc(C(F)F)c2)c2cccc(F)c21 CHEMBL2177913 IC50 0.6 nM
CC#Cc1cncc(-c2ccc3c(c2)[C@@]2(N=C(C)C(N)=N2)[C@]2(CC[C@@H](OC)CC2)C3)c1 CHEMBL4217620 IC50 0.6 nM
CC#CCOc1cnc(C(=O)Nc2ccc(Cl)c([C@@]3(CF)N=C(N)O[C@@H]4C[C@@H]43)c2)cn1 CHEMBL3688710 IC50 0.6 nM
C#CCOc1cnc(C(=O)Nc2cc(F)c(F)c([C@@]3(CF)N=C(N)S[C@H]4C[C@H]43)c2)cn1 CHEMBL4454250 IC50 0.6 nM
Cc1cc(C#N)cnc1C(=O)Nc1ccc(F)c([C@@]2(C)N=C(N)C(C)(C)[S@@]3(=O)=NCC[C@@H]23)n1 CHEMBL4578357 IC50 0.6 nM
C[C@]1(c2cc(NC(=O)c3ccc(Cl)cn3)cc(F)c2F)N=C(N)S[C@@]2(C(N)=O)C[C@H]21 CHEMBL4468455 IC50 0.6 nM
CC#Cc1cncc(-c2ccc3c(c2)[C@@]2(N=C(C)C(N)=N2)[C@]2(CC[C@H](OC)CC2)C3)c1 CHEMBL3989948 IC50 0.6 nM
NC1=N[C@@]2(c3cccc(NC(=O)c4ccc(F)cn4)c3)CN(c3ncc(F)cn3)C[C@H]2CS1 CHEMBL3667408 IC50 0.61 nM
C[C@]1(c2cc(NC(=O)c3ccc(C#N)cn3)ccc2F)N=C(N)OCC12CC(F)(F)C2 CHEMBL4439134 IC50 0.615 nM
COc1cnc(C(=O)Nc2ccc(F)c([C@]34CN(c5ncc(F)cn5)C[C@H]3CSC(N)=N4)c2)cn1 CHEMBL4452566 IC50 0.615 nM
CC1(C)Oc2ccc(NC(=O)c3ccc(F)cn3)cc2[C@@]2(COC(N)=N2)C12CC2 CHEMBL3650849 IC50 0.62 nM
NC1=N[C@@]2(CO1)c1cc(NC(=O)c3ccc(Cl)cn3)ccc1Oc1cnc(C3=CCCOC3)cc12 CHEMBL4294221 IC50 0.62 nM
N#Cc1ccc(C(=O)Nc2ccc(F)c([C@]3(CF)CCSC(N)=N3)c2)nc1 CHEMBL4865251 IC50 0.62 nM
COc1cc(/C=C/c2nnc(-c3ccc(F)cc3F)o2)ccc1O CHEMBL5286535 IC50 0.624 nM
COc1cc(/C=C/c2nnc(-c3ccc(Cl)cc3)o2)ccc1O CHEMBL5266033 IC50 0.628 nM
CO[C@H]1CC[C@]2(CC1)Cc1ccc(-c3cc(Cl)cc(C#N)c3)cc1[C@@]21N=C(C)C(N)=N1 CHEMBL3890867 IC50 0.63 nM
CC1(C)Oc2ccc(NC(=O)c3cnc(C(F)F)cn3)cc2[C@@]2(COC(N)=N2)C12CC2 CHEMBL3650851 IC50 0.63 nM
C[C@@]1(c2cc(NC(=O)c3ccc(C#N)cn3)ccc2F)CCSC(N)=N1 CHEMBL4535964 IC50 0.63 nM
C[C@H]1C[C@H]2CSC(N)=N[C@@]2(c2nc(NC(=O)c3ccn(C(F)F)n3)cs2)CO1 CHEMBL4215837 IC50 0.64 nM
Cc1ccccc1-c1ccc2nc(N)c(C[C@@H](C)C(=O)NCCC(C)(C)C)cc2c1 CHEMBL1821820 IC50 0.65 nM
Cc1nc(C(=O)Nc2ccc(F)c([C@]3(C)Cn4nc(C#N)cc4C(N)=N3)c2)co1 CHEMBL5093195 Ki 0.69 nM
COC[C@H]1CCCN1C(=O)c1cc(C)cc(C(=O)N[C@@H](Cc2cc(F)cc(F)c2)[C@H](O)[C@H]2C[C@@H](Oc3ccccc3)CN2)c1 CHEMBL403195 IC50 0.7 nM
Cc1ccccc1-c1ccc2nc(N)c(C[C@@H](C)C(=O)N[C@@H]3CCOC(C)(C)C3)cc2c1 CHEMBL1821728 IC50 0.7 nM
CC(=O)N[C@@H](Cc1ccc(F)c(F)c1)[C@H](O)CN[C@H]1C[C@]2(C[C@@H](C)C2)Oc2ncc(CC(C)(C)C)cc21 CHEMBL2031142 IC50 0.7 nM
CC(=O)N[C@@H](Cc1ccc(F)c(F)c1)[C@H](O)CN[C@H]1C[C@]2(C[C@H](C)C2)Oc2ncc(CC(C)(C)C)cc21 CHEMBL2031143 IC50 0.7 nM
CC1(C#Cc2cnc3c(c2)[C@]2(COC(N)=N2)c2cc(-c4cccnc4F)ccc2O3)COC1 CHEMBL3359763 IC50 0.7 nM
CC(C)(C)COc1cnc2c(c1)[C@]1(COC(N)=N1)c1cc(-c3cncnc3)ccc1O2 CHEMBL3359747 IC50 0.7 nM
NC1=N[C@@]2(CO1)c1cc(-c3cccnc3F)ccc1Oc1cnc(C3=CCOCC3)cc12 CHEMBL3394039 IC50 0.7 nM
NC1=N[C@@]2(CO1)c1cc(-c3cccnc3F)ccc1Oc1cnc(N3CCC(F)(F)CC3)cc12 CHEMBL3394048 IC50 0.7 nM
NC1=N[C@@]2(CO1)c1cc(-c3cccnc3F)ccc1Oc1c2cc(-c2ccccc2)nc1F CHEMBL3394210 IC50 0.7 nM
NC1=N[C@@]2(CO1)c1cc(-c3cccnc3F)ccc1Oc1c2cc(C2CCOCC2)nc1F CHEMBL3394223 IC50 0.7 nM
COc1cnc(C(=O)Nc2cc(F)c(F)c([C@]3(C)C[C@@H](c4c(C)noc4C)SC(N)=N3)c2)cn1 CHEMBL3805852 IC50 0.7 nM
Cc1noc(C)c1[C@@H]1C[C@@](C)(c2cc(NC(=O)c3ccc(Cl)cn3)cc(F)c2F)N=C(N)S1 CHEMBL3806322 IC50 0.7 nM
CC1=NC2(CC(C3CCCOC3)Oc3ccc(-c4cccc(Cl)c4)cc32)N=C1N CHEMBL3653702 IC50 0.7 nM
CO[C@H]1CC[C@]2(CC1)Cc1ccc(-c3cc(Br)cc(C#N)c3)cc1C21N=C(C)C(N)=N1 CHEMBL3936953 IC50 0.7 nM
CN1C(=O)C[C@]2(N=C1N)c1cc(-c3cccnc3F)ccc1Oc1c2cc(C2=CCOC(C)(C)C2)nc1F CHEMBL3695752 IC50 0.7 nM
NC1=N[C@@]2(c3cc(-c4cccnc4F)ccc3Oc3c(F)cc(N4CCOCC4)cc32)c2nccn21 CHEMBL3677276 IC50 0.7 nM
NC1=N[C@]2(c3cc(-c4cccnc4F)ccc3Oc3c(F)cc([N+]4=CCC(F)(F)CC4)cc32)c2nccn21 CHEMBL4109723 IC50 0.7 nM
CC#CCOc1cnc(C(=O)Nc2ccc(F)c([C@]3(CF)C[C@@H](C(F)(F)F)OC(N)=N3)c2)cn1 CHEMBL3893892 IC50 0.7 nM
COc1nc(N2C[C@H]3C(=O)N(C)C(=N)N[C@@]3(c3cc(-c4cccc(C#N)c4)cs3)C2)nc(C)c1F CHEMBL4293298 Ki 0.7 nM
Cc1nc(N2C[C@H]3C(=O)N(C)C(=N)N[C@@]3(c3cc(-c4cccc(C#N)c4)cs3)C2)ncc1F CHEMBL4289763 Ki 0.7 nM
C#CCOc1ccc(C(=O)Nc2cc(F)c(F)c([C@@]3(C)N=C(N)S[C@@]4(COC)C[C@H]43)c2)nc1 CHEMBL4456778 IC50 0.7 nM
CO[C@H]1CC[C@]2(CC1)Cc1ccc(-c3cc(Cl)cc(C#N)c3)cc1C21N=C(C)C(N)=N1 CHEMBL2152915 IC50 0.72 nM
CO[C@H]1CC[C@]2(CC1)Cc1ccc(-c3cncc(Br)c3)cc1C21N=C(C)C(N)=N1 CHEMBL2152918 IC50 0.72 nM
CO[C@H]1CC[C@]2(CC1)Cc1ccc(-c3cc(Cl)c(F)c(C#N)c3)cc1[C@@]21N=C(C)C(N)=N1 CHEMBL3974225 IC50 0.72 nM
NC1=N[C@@]2(c3cc(NC(=O)c4ncc(F)cc4F)ccc3F)CN(c3ncc(F)cn3)C[C@H]2CS1 CHEMBL3667415 IC50 0.73 nM
NC1=N[C@@]2(c3cccc(NC(=O)c4ncc(F)cc4F)c3)CN(c3ncc(F)cn3)C[C@H]2CS1 CHEMBL3667413 IC50 0.739 nM
N#Cc1ccc(C(=O)Nc2ccc3c(c2)C2(CCOC(N)=N2)c2cc(C4=CCOCC4)nc(F)c2O3)nc1 CHEMBL3980947 IC50 0.74 nM
CCC#Cc1cncc(-c2ccc3c(c2)C2(N=C(C)C(N)=N2)[C@]2(CC[C@H](OC)CC2)C3)c1 CHEMBL2152920 IC50 0.76 nM
CCn1cc([C@]2(c3cccc(C#CC4CC4)c3)N=C(N)c3c(F)cccc32)cc(C)c1=O CHEMBL2177304 IC50 0.76 nM
COc1ncc(CC2CCOCC2)c2c1C[C@]1(c3ccc(F)cc3F)N=C(N)SC[C@@H]1C2 CHEMBL4530208 IC50 0.76 nM
CC1(C)Oc2ccc(NC(=O)c3ccc(Cl)cn3)cc2[C@@]2(COC(N)=N2)C12COC2 CHEMBL3650845 IC50 0.78 nM
CSCC[C@H](NC(=O)[C@@H](NC(=O)OC(C)(C)C)C(C)C)C(=O)N[C@@H](CC(C)C)[C@@H](O)C[C@@H](C)C(=O)N[C@H](C(=O)NCC(C)C)C(C)C CHEMBL445804 Ki 0.8 nM
COC[C@H]1CCCN1C(=O)c1cc(C)cc(C(=O)N[C@@H](Cc2cc(F)cc(F)c2)[C@H](O)[C@H]2CN(S(=O)(=O)c3cccc(C)c3)CCN2)c1 CHEMBL1097342 Ki 0.8 nM
CC(C)(C)COc1ccc2c(c1)[C@]1(COC(N)=N1)c1cc(-c3cccnc3F)ccc1O2 CHEMBL3354709 IC50 0.8 nM
N#Cc1ccc(-c2cnc3c(c2)[C@]2(COC(N)=N2)c2cc(-c4cccnc4F)ccc2O3)cc1 CHEMBL3359758 IC50 0.8 nM
Cc1cc(-c2cc3c(c(F)n2)Oc2ccc(-c4cccnc4F)cc2[C@@]32COC(N)=N2)ccn1 CHEMBL3394214 IC50 0.8 nM
COC1CCC2(CC1)Cc1ccc(-c3cc(Cl)cc(C#N)c3)cc1C21N=C(N)N(C)C1=O CHEMBL3901821 IC50 0.8 nM
NC1=NC2(CCS1)c1cc(NC(=O)c3ccc(Cl)cn3)ccc1Oc1c2cc(C2=CCCOC2)nc1F CHEMBL3914230 IC50 0.8 nM
Cc1nc(C(=O)Nc2ccc3c(c2)C2(CCOC(N)=N2)c2cc(-c4ccnc(F)c4)nc(F)c2O3)cs1 CHEMBL3948791 IC50 0.8 nM
COC[C@]12C[C@H]1[C@@](C)(c1cc(NC(=O)c3cnc(OCC(F)(F)F)cn3)cc(F)c1F)N=C(N)S2 CHEMBL4579155 IC50 0.8 nM
C[C@H]1SC(N)=N[C@](C)(c2cc(NC(=O)c3cc4c(cn3)OCCO4)ccc2F)[C@H]1F CHEMBL5075689 Ki 0.8 nM
COc1cc(C#N)cc(-c2ccc3c(c2)[C@@]2(N=C(C)C(N)=N2)[C@]2(CC[C@H](OC)CC2)C3)c1 CHEMBL3902302 IC50 0.84 nM
C[C@@]1(c2cc(NC(=O)c3ccc(Cl)cn3)ccc2F)CCSC(N)=N1 CHEMBL2347211 IC50 0.84 nM
C[C@@]1(c2cc(C(=O)Nc3ccc(Cl)cn3)ccc2F)CCSC(N)=N1 CHEMBL4866376 IC50 0.84 nM
COc1cc(/C=C/c2nnc(-c3ccc(Cl)cc3Cl)o2)ccc1O CHEMBL5272625 IC50 0.864 nM
CC#CCOc1cnc(C(=O)Nc2cc(F)c(F)c([C@]3(CF)C[C@@H](C(F)(F)F)OC(N)=N3)c2)cn1 CHEMBL3904438 IC50 0.87 nM
CN1C(=N)N[C@](C)(c2sc(-c3cccc(-c4ncno4)c3)cc2F)CS1(=O)=O CHEMBL3910228 Ki 0.87 nM
CCC(C)[C@@]1(NC(C)=O)CCN([C@@H](CCc2ccccc2)C(=O)N[C@@H](Cc2cc(F)cc(F)c2)[C@H](O)[C@H]2C[C@H](O)CN2)C1=O CHEMBL1916003 IC50 0.89 nM
Cc1ccc(-c2cnc3c(c2)[C@]2(COC(N)=N2)c2cc(-c4cccnc4F)ccc2O3)cc1 CHEMBL3359757 IC50 0.9 nM
CC1(C)C=C(c2cnc3c(c2)[C@]2(COC(N)=N2)c2cc(-c4cccnc4F)ccc2O3)CCO1 CHEMBL3359755 IC50 0.9 nM
CC1(C)C=C(c2cc3c(cn2)Oc2ccc(-c4cccnc4F)cc2[C@@]32COC(N)=N2)CCO1 CHEMBL3394040 IC50 0.9 nM
NC1=N[C@@]2(CO1)c1cc(-c3cccnc3F)ccc1Oc1cnc(-c3ccnc(F)c3)cc12 CHEMBL3394057 IC50 0.9 nM
CN1C(=O)[C@]2(N=C1N)c1cc(C3=CCOCC3)ccc1Oc1ccc(-c3cccnc3F)cc12 CHEMBL3695728 IC50 0.9 nM
COc1cnc(C(=O)Nc2ccc3c(c2)C2(CCOC(N)=N2)c2cc(C4=CCOCC4)nc(F)c2O3)cn1 CHEMBL3952111 IC50 0.9 nM
COc1ccc(C(=O)Nc2ccc3c(c2)C2(CCOC(N)=N2)c2cc(C4=CCCOC4)nc(F)c2O3)nc1 CHEMBL3973477 IC50 0.9 nM
Cc1nc(C(=O)Nc2ccc3c(c2)C2(CCOC(N)=N2)c2cc(C4=CCCOC4)nc(F)c2O3)cs1 CHEMBL3963996 IC50 0.9 nM
NC1=NC2(CCO1)c1cc(NC(=O)c3ccc(Cl)cn3)ccc1Oc1c2cc(-c2ccnc(F)c2)nc1F CHEMBL3922952 IC50 0.9 nM
[2H]C1([2H])OC(N)=N[C@]12c1cc(-c3cncnc3)ccc1C[C@]21CC[C@@H](OC)[C@H](C)C1 CHEMBL4103296 IC50 0.9 nM
CN1C(=N)N[C@](C)(c2cc(NC(=O)c3ccc(Cl)cn3)ccc2F)CS1(=O)=O CHEMBL3672916 IC50 0.9 nM
COc1cnc(C(=O)Nc2ccnc([C@]34CN(c5ncc(F)cn5)C[C@H]3CSC(N)=N4)c2)cn1 CHEMBL4526395 IC50 0.9 nM
C[C@]1(c2cc(/C=C(\F)c3ccc(C#N)cn3)ccc2F)N=C(N)S[C@@]2(C(=O)N3CCCC3)C[C@H]21 CHEMBL4740498 IC50 0.9 nM
C[C@]1(c2cc(/C=C(\F)c3ccc(C#N)cn3)ccc2F)N=C(N)S[C@@]2(C(=O)N3CCCCC3)C[C@H]21 CHEMBL4746645 IC50 0.9 nM
[2H]C1([2H])OC(N)=N[C@]12c1cc(-c3cncnc3)ccc1C[C@]21CC[C@@H](OC)[C@H](CC)C1 CHEMBL4097477 IC50 0.91 nM
NC1=N[C@@]2(CO1)c1cc(-c3cccc(F)n3)ccc1Oc1cnc(-c3ccnc(F)c3)cc12 CHEMBL4285211 IC50 0.92 nM
C[C@@]1(c2cc(NC(=O)c3ccc(C#N)cc3)ccc2F)Cn2cnc(C(F)F)c2C(N)=N1 CHEMBL4525240 IC50 0.95 nM
COC1CCC2(CC1)Cc1ccc(-c3cc(F)cc(C#N)c3)cc1C21N=C(N)N(C)C1=O CHEMBL3972883 IC50 0.96 nM
CC(=O)N[C@@H](Cc1ccc(C)c(F)c1)[C@H](O)CN[C@H]1CC2(CCC2)Oc2ncc(CC(C)(C)C)cc21 CHEMBL2151243 IC50 0.99 nM
Cc1cc(C#N)cnc1C(=O)Nc1ccc(F)c([C@]2(C)C[S@@](=O)(=NCC(F)(F)F)N(C)C(N)=N2)c1 CHEMBL4573117 IC50 0.99 nM
Cc1cc(C#N)cnc1C(=O)Nc1ccc(F)c([C@]2(C)C[S@](=O)(=NCC(F)(F)F)N(C)C(N)=N2)c1 CHEMBL4740455 IC50 0.99 nM
CCCC(CCC)S(=O)(=O)C[C@@H](NC(=O)c1cccnc1)C(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)CNCc1cccc(CC)c1 CHEMBL231862 IC50 1.0 nM
CCCCS(=O)(=O)C[C@@H](NC(=O)c1ccncc1)C(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)CNCc1cccc(CC)c1 CHEMBL394271 EC50 1.0 nM
CCCCS(=O)(=O)C[C@@H](NC(=O)c1cccnc1)C(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)CNCc1cccc(CC)c1 CHEMBL266567 EC50 1.0 nM
C[C@@]1(N)Cc2cccc(c2)CC[C@H](c2ccccc2)NC(=O)c2cc(cc(N(c3ccccc3)S(C)(=O)=O)c2)COC1=O CHEMBL250295 IC50 1.0 nM
COC[C@H]1CCCN1C(=O)c1cc(C)cc(C(=O)N[C@@H](Cc2cc(F)cc(F)c2)[C@H](O)[C@@H]2NCCN(Cc3ccccc3)C2=O)c1 CHEMBL510659 IC50 1.0 nM
CCCN(CCC)C(=O)c1cc(C(=O)N[C@@H](Cc2cc(F)cc(F)c2)[C@H](O)CNCc2cccc(OC)c2)cc(/C(C)=N\OC)c1 CHEMBL555517 IC50 1.0 nM
CCCS(=O)(=O)N(C)c1cc2cc(c1)C(=O)N[C@H]([C@H](O)CNCc1cccc(C(C)C)c1)Cc1cccc(c1)OCCCCN2 CHEMBL595016 IC50 1.0 nM
CC(C)c1cccc(C2(NC[C@@H](O)[C@@H]3Cc4cccc(c4)OCCCCOc4cc(cc(N5CCCC5=O)c4)C(=O)N3)CC2)c1 CHEMBL595100 IC50 1.0 nM
CCCN(CCC)C(=O)c1cc(C)cc(C(=O)N[C@@H](Cc2cc(F)cc(F)c2)[C@H](O)[C@H]2CN(S(=O)(=O)c3cccc(C)c3)CCN2)c1 CHEMBL1097321 Ki 1.0 nM
Cc1cccc(S(=O)(=O)N2CCN[C@@H]([C@@H](O)[C@H](Cc3cc(F)cc(F)c3)NC(=O)c3cc(C(=O)N[C@H](C)c4ccccc4)cc(N4CCCCS4(=O)=O)c3)C2)c1 CHEMBL1097344 Ki 1.0 nM
CCNc1cc(C(=O)N[C@@H](Cc2cc(F)cc(F)c2)[C@H](O)[C@H]2CN(S(=O)(=O)c3cccc(C)c3)CCN2)cc(N2CCCCS2(=O)=O)c1 CHEMBL1097345 Ki 1.0 nM
CCNc1cc(C(=O)N[C@@H](Cc2cc(F)cc(F)c2)[C@H](O)[C@H]2CN(S(=O)(=O)c3cccc(C)c3)CCN2)cc(N(C)S(C)(=O)=O)c1 CHEMBL1097346 Ki 1.0 nM
COC[C@H]1CCCN1C(=O)c1cc(C)cc(C(=O)N[C@@H](Cc2cc(F)cc(F)c2)[C@H](O)[C@H]2CN(S(=O)(=O)c3ccccc3)CCN2)c1 CHEMBL1097348 Ki 1.0 nM
COC[C@H]1CCCN1C(=O)c1cc(C)cc(C(=O)N[C@@H](Cc2cc(F)cc(F)c2)[C@H](O)[C@H]2CN(S(=O)(=O)c3cccc(Cl)c3)CCN2)c1 CHEMBL1097349 Ki 1.0 nM
COC[C@H]1CCCN1C(=O)c1cc(C)cc(C(=O)N[C@@H](Cc2cc(F)cc(F)c2)[C@H](O)[C@H]2CN(S(=O)(=O)c3ccc(Cl)s3)CCN2)c1 CHEMBL1097351 Ki 1.0 nM
COC[C@H]1CCCN1C(=O)c1cc(C)cc(C(=O)N[C@@H](Cc2cc(F)cc(F)c2)[C@H](O)[C@H]2CN(S(=O)(=O)Cc3ccccc3)CCN2)c1 CHEMBL1097353 Ki 1.0 nM
CC(=O)N[C@@H](Cc1cccc(F)c1)[C@H](O)CN[C@H]1CC2(CCC2)Oc2ncc(CC(C)(C)C)cc21 CHEMBL2030996 IC50 1.0 nM
COc1cccc(N2C[C@H]3C(=O)N(C)C(=N)N[C@@]3(c3cc(-c4cccc(C#N)c4)cs3)C2)n1 CHEMBL2178715 Ki 1.0 nM
CC#Cc1cncc(-c2csc([C@]34CN(C(=O)c5cccc(F)c5)C[C@H]3C(=O)N(C)C(=N)N4)c2)c1 CHEMBL2178147 Ki 1.0 nM
C[C@]1(c2cc(NC(=O)c3ccc(C#N)cn3)ccc2F)N=C(N)OC[C@@H]1F CHEMBL2347204 IC50 1.0 nM
CC#CCOc1cnc(C(=O)Nc2ccc(F)c([C@@]3(C)N=C(N)OCC3(F)F)c2)cn1 CHEMBL2347198 IC50 1.0 nM
C#CCOc1cnc(C(=O)Nc2ccc(F)c([C@@]3(C)N=C(N)OCC3(F)F)c2)cn1 CHEMBL2347197 IC50 1.0 nM
C[C@@]1(c2cc(NC(=O)c3ccc(Cl)cn3)ccc2F)CCOCC(N)=N1 CHEMBL2403777 IC50 1.0 nM
C[C@@]1(c2cc(NC(=O)c3ncc(Cl)cc3Cl)ccc2F)CCOC(N)=N1 CHEMBL2403768 IC50 1.0 nM
CN1C(=O)C[C@@](C)(c2cccc(NC(=O)c3ccc(Cl)cn3)c2)N=C1N CHEMBL2403765 IC50 1.0 nM
C[C@]1(c2cc(NC(=O)c3ccc(Cl)cn3)ccc2F)N=C(N)COCC1(F)F CHEMBL3261062 IC50 1.0 nM
CC1(COc2cc(F)c3c(c2)[C@]2(COC(N)=N2)c2cc(-c4cccnc4)ccc2O3)COC1 CHEMBL3354713 IC50 1.0 nM
NC1=N[C@@]2(CO1)c1cc(-c3cccnc3F)ccc1Oc1c2cc(C2CCCOC2)nc1F CHEMBL3394222 IC50 1.0 nM
C[C@]1(c2cc(NC(=O)c3ncc(F)cc3F)ccc2F)N=C(N)OC[C@@H]1F CHEMBL3680856 IC50 1.0 nM
C[C@]1(c2cc(NC(=O)c3ccc(OCF)cn3)ccc2F)N=C(N)OC[C@@H]1F CHEMBL3680857 IC50 1.0 nM
C[C@]1(c2cc(NC(=O)c3ccc(Cl)cn3)ccc2F)N=C(N)OC[C@@H]1OCC(F)(F)F CHEMBL3680895 IC50 1.0 nM
C[C@]1(c2cc(NC(=O)c3ccc(C#N)cn3)ccc2F)N=C(N)OC[C@@H]1OCC(F)(F)F CHEMBL3680897 IC50 1.0 nM
C[C@@]1(c2cc(NC(=O)c3ncc(C#N)cc3Cl)ccc2F)C[S@@]2(=O)=NCCCCN2C(N)=N1 CHEMBL3741792 IC50 1.0 nM
CC#CCOc1cnc(C(=O)Nc2ccc(F)c([C@]3(C(F)F)COCC(N)=N3)c2)cn1 CHEMBL3653487 IC50 1.0 nM
COc1cc(C#N)cc(-c2ccc3c(c2)[C@@]2(N=C(C)C(N)=N2)[C@]2(CC[C@H](OC(F)F)CC2)C3)c1 CHEMBL3657429 IC50 1.0 nM
CC#CCOc1cnc(C(=O)Nc2ccc(F)c([C@@]3(C(F)F)N=C(N)O[C@@H]4C[C@@H]43)c2)cn1 CHEMBL3683852 IC50 1.0 nM
COC1CCC2(CC1)Cc1ccc(-c3cc(F)cc(F)c3)cc1C21N=C(N)N(C)C1=O CHEMBL3910991 IC50 1.0 nM
C#CCOc1cnc(C(=O)Nc2cc(C)c(F)c([C@]3(CF)C[C@@H](C(F)(F)F)OC(N)=N3)c2)cn1 CHEMBL3904149 IC50 1.0 nM
C#CCOc1cnc(C(=O)Nc2cc(Cl)c(F)c([C@]3(C)C[C@@H](C(F)(F)F)OC(N)=N3)c2)cn1 CHEMBL3979143 IC50 1.0 nM
N#Cc1ccc(C(=O)Nc2ccc3c(c2)C2(CCOC(N)=N2)c2cc(-c4ccnc(F)c4)cc(F)c2O3)nc1 CHEMBL3971440 IC50 1.0 nM
NC1=NC2(CCS1)c1cc(NC(=O)c3ccc(F)cn3)ccc1Oc1c2cc(C2=CCOCC2)nc1F CHEMBL3903132 IC50 1.0 nM
NC1=NC2(CCS1)c1cc(NC(=O)c3ccc(Cl)cn3)ccc1Oc1c2cc(C2=CCOCC2)nc1F CHEMBL3979006 IC50 1.0 nM
C[C@H]1C[C@H]2CSC(N)=N[C@@]2(c2cc(NC(=O)c3ccc(Cl)cn3)ccc2F)CO1 CHEMBL3983509 IC50 1.0 nM
NC1=NC2(COCC1)c1cc(-c3cccnc3F)ccc1Oc1cnc(-c3ccnc(F)c3)cc12 CHEMBL3951405 IC50 1.0 nM
CC(C)(C)COc1cc(F)c2c(c1)C1(COCCC(N)=N1)c1cc(-c3cccnc3F)ccc1O2 CHEMBL3975488 IC50 1.0 nM
CC1(C)C(=N)N[C@@]2(c3cc(NC(=O)c4ccc(C#N)cn4)ccc3F)COC[C@H]2S1(=O)=O CHEMBL4113105 Ki 1.0 nM
Cc1cc(C#N)cnc1C(=O)Nc1ccc(F)c([C@]23COC[C@H]2S(=O)(=O)C(C)(C)C(=N)N3)c1 CHEMBL4110175 Ki 1.0 nM
C#CCOc1cnc(C(=O)Nc2ccc(F)c([C@]34COC[C@H]3S(=O)(=O)C(C)(C)C(=N)N4)c2)cn1 CHEMBL4114508 Ki 1.0 nM
C#CCOc1ccc(C(=O)Nc2ccc(F)c([C@]34COC[C@H]3S(=O)(=O)C(C)(C)C(=N)N4)c2)nc1 CHEMBL4112828 Ki 1.0 nM
CC1(C)C(=N)N[C@@]2(c3cc(NC(=O)c4ccn(C(F)F)n4)ccc3F)COC[C@H]2S1(=O)=O CHEMBL4107791 Ki 1.0 nM
CC1(C)C(=N)N[C@@]2(c3cc(NC(=O)c4ccc(Cl)cn4)ccc3F)COC(CF)[C@H]2S1(=O)=O CHEMBL4110277 Ki 1.0 nM
C[C@@]1(c2ccc(F)cc2)C(=N)N[C@@]2(c3cc(NC(=O)c4ccc(F)cn4)ccc3F)COC[C@H]2S1(=O)=O CHEMBL4112573 Ki 1.0 nM
CNS1(O)C[C@@](C)(c2cc(NC(=O)c3ccc(Cl)cn3)ccc2F)NC(=N)N1C CHEMBL3920380 Ki 1.0 nM
Cc1nc(N2C[C@H]3C(=O)N(C)C(=N)N[C@@]3(c3cc(-c4cccc(C#N)c4)cs3)C2)nc(C)c1F CHEMBL4288838 Ki 1.0 nM
CN1C(=N)N[C@@]2(c3cc(-c4cccc(C#N)c4)cs3)CN(c3ncc(F)c(N4CCOCC4)n3)C[C@H]2C1=O CHEMBL4278154 Ki 1.0 nM
CCCOc1nc(N2C[C@H]3C(=O)N(C)C(=N)N[C@@]3(c3cc(-c4cccc(C#N)c4)cs3)C2)ncc1F CHEMBL4278011 Ki 1.0 nM
CCOc1nc(N2C[C@H]3C(=O)N(C)C(=N)N[C@@]3(c3cc(-c4cccc(C#N)c4)cs3)C2)ncc1F CHEMBL4294236 Ki 1.0 nM
COc1nc(N2C[C@H]3C(=O)N(C)C(=N)N[C@@]3(c3cc(-c4cccc(C#N)c4)cs3)C2)ncc1F CHEMBL3800286 Ki 1.0 nM
CCc1nc(N2C[C@H]3C(=O)N(C)C(=N)N[C@@]3(c3cc(-c4cccc(C#N)c4)cs3)C2)ncc1F CHEMBL4279084 Ki 1.0 nM
CN1C(=N)N[C@@]2(c3cc(-c4cccc(Cl)c4)cs3)CN(c3ncc(F)cn3)C[C@H]2C1=O CHEMBL4280271 Ki 1.0 nM
COc1cc(C#N)cc(-c2csc([C@]34CN(c5ncc(F)cn5)C[C@H]3C(=O)N(C)C(=N)N4)c2)c1 CHEMBL4278329 Ki 1.0 nM
COC[C@H]1SC(N)=N[C@](C)(c2cc(NC(=O)c3ccc(C#N)cn3)ccc2F)[C@H]1F CHEMBL4537415 IC50 1.0 nM
C#CCOc1cnc(/C(F)=C/c2ccc(F)c([C@]3(C)CS(=O)(=O)C(C)(C)C(N)=N3)c2)cn1 CHEMBL4470897 IC50 1.0 nM
C[C@@]1(c2cc(NC(=O)c3ccc(C#N)cn3)ccc2F)Cn2nncc2C(N)=N1 CHEMBL4441612 IC50 1.0 nM
CN1C(N)=N[C@]2(C)c3cc(NC(=O)c4ccc(C#N)cn4)ccc3OCC[C@H]2S1(=O)=O CHEMBL4455948 Ki 1.0 nM
C[C@]1(c2cc(/C=C(\F)c3ccc(C#N)cn3)ccc2F)N=C(N)S[C@@]2(C(=O)N3CCC3)C[C@H]21 CHEMBL4790308 IC50 1.0 nM
C[C@]1(c2cc(/C=C(\F)c3cnc(C#N)cn3)ccc2F)N=C(N)S[C@@]2(C(=O)N3CCOCC3)C[C@H]21 CHEMBL4800593 IC50 1.0 nM
Cc1cc(C#N)cnc1C(=O)Nc1ccc(F)c([C@]2(C)CS(=O)(=O)[C@@](C)(CF)C(=N)N2)n1 CHEMBL5190011 Ki 1.0 nM
Cc1cc(C#N)cnc1C(=O)Nc1ccc(F)c([C@]2(C)CS(=O)(=O)[C@@](C)(C(F)F)C(=N)N2)n1 CHEMBL5198665 Ki 1.0 nM
CC1(C)C(=N)N[C@](C)(c2nc(NC(=O)c3ccc(C#N)cn3)ccc2F)CS1(=O)=O CHEMBL5174392 IC50 1.0 nM
CC(F)(F)[C@H]1OC[C@]2(c3cc(NC(=O)c4ccc(C(F)(F)F)cn4)ccc3F)N=C(N)SC[C@H]12 CHEMBL4591139 IC50 1.03 nM
NC1=N[C@@]2(c3cc(NC(=O)c4ccc(C(F)(F)F)cn4)ccc3F)CO[C@H](C(F)(F)F)[C@H]2CO1 CHEMBL4515824 IC50 1.03 nM
COc1cnc(C(=O)Nc2cc(F)c(F)c([C@]3(C)CS(=O)(=O)N(C)C(=N)N3)c2)cn1 CHEMBL3672919 Ki 1.05 nM
CC#CCOc1cnc(C(=O)Nc2ccc(F)c([C@]3(C)CC(=O)N(C)C(N)=N3)c2)cn1 CHEMBL4086961 IC50 1.05 nM
CC(C)C[C@H](NC(=O)c1cc(C(=O)N[C@H](C)c2ccccc2)cc(N(C)S(C)(=O)=O)c1)[C@@H](O)C[C@@H](C)C(=O)N[C@H](C(=O)NC(C)C)C(C)C CHEMBL387771 Ki 1.1 nM
CC#Cc1cncc(-c2ccc3c(c2)C2(C=C(F)C(N)=N2)[C@]2(CC[C@@H](OC)CC2)C3)c1 CHEMBL2408785 IC50 1.1 nM
CO[C@H]1CC[C@]2(CC1)Cc1ccc(-c3cncnc3)cc1C21C=C(F)C(N)=N1 CHEMBL2408787 IC50 1.1 nM
CO[C@H]1CC[C@]2(CC1)Cc1ccc(-c3cncc(Cl)c3)cc1[C@@]21N=C(C)C(N)=N1 CHEMBL3905878 IC50 1.1 nM
CO[C@H]1CC[C@]2(CC1)Cc1ccc(C#CC(C)C)cc1[C@]21N=C(C)C(N)=N1 CHEMBL4110988 IC50 1.1 nM
COC1CCC2(CC1)Cc1ccc(-c3cc(F)cc(Cl)c3)cc1C21N=C(N)N2CCON=C21 CHEMBL3673207 IC50 1.1 nM
[C-]#[N+]c1cc(C#N)cc(-c2ccc3c(c2)C2(N=C(N)N(C)C2=O)C2(CCC(OC)CC2)C3)c1 CHEMBL3933430 IC50 1.1 nM
Cc1onc2c1CC1(CC2)Cc2ccc(-c3cc(F)cc(Cl)c3)cc2C12N=C(N)N(C)C2=O CHEMBL3983916 IC50 1.1 nM
NC1=NC2(CCO1)c1cc(NC(=O)c3cnc(F)cn3)ccc1Oc1c2cc(-c2cccnc2)nc1F CHEMBL3908041 IC50 1.1 nM
COc1ccc(C(=O)Nc2ccc3c(c2)C2(CCOC(N)=N2)c2cc(-c4ccnc(F)c4)nc(F)c2O3)nc1 CHEMBL3904830 IC50 1.1 nM
COc1ccc(C(=O)Nc2ccc3c(c2)C2(CCSC(N)=N2)c2cc(-c4cncc(F)c4)nc(F)c2O3)nc1 CHEMBL3965633 IC50 1.1 nM
CN1C(=N)N[C@](C)(c2sc(-c3cc(-c4nnco4)ccc3F)cc2F)CS1(=O)=O CHEMBL3903571 Ki 1.1 nM
[2H]C1([2H])OC(N)=N[C@]12c1cc(-c3cncnc3)ccc1C[C@@]21CC[C@H](OC)[C@@H](C)C1 CHEMBL4070299 IC50 1.1 nM
C[C@@H](F)[C@H]1OC(N)=N[C@](C)(c2cc(NC(=O)c3cnc(OCF)cn3)ccc2F)[C@H]1F CHEMBL4226007 IC50 1.1 nM
C[C@]1(c2cc(NC(=O)c3ccc(Cl)cn3)cc(F)c2F)N=C(N)S[C@@]2(C(F)F)C[C@@H]12 CHEMBL4457316 IC50 1.1 nM
CCCOc1cnc(C(=O)Nc2cc(F)c(F)c([C@@]3(C)N=C(N)S[C@@]4(COC)C[C@H]43)c2)cn1 CHEMBL4575413 IC50 1.1 nM
C=C1C[C@@](C)(c2cc(NC(=O)c3ccc(C#N)cn3)ccc2F)N=C(N)S1 CHEMBL3961031 IC50 1.1 nM
C[C@H]1SC(N)=N[C@](C)(c2cc(NC(=O)c3ccc(OCF)cn3)ccc2F)[C@H]1F CHEMBL5093159 IC50 1.1 nM
CC(C)(C)C(=O)N[C@H]1CC[C@@H]2Oc3ccc(-c4cncc(F)c4)cc3C3(CSC(N)=N3)[C@H]2C1 CHEMBL5201184 IC50 1.1 nM
CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)CNC(=O)c1nn[nH]n1)C(C)C)C(=O)N[C@@H](Cc1ccccc1)[C@@H](O)C(=O)Nc1cc(-c2nn[nH]n2)cc(-c2nn[nH]n2)c1 CHEMBL439521 IC50 1.2 nM
CC(C)(O)C#Cc1cnc2c(c1)[C@]1(COC(N)=N1)c1cc(-c3cccnc3F)ccc1O2 CHEMBL3359762 IC50 1.2 nM
NC1=N[C@@]2(CO1)c1cc(-c3cccnc3F)ccc1Oc1ncc(C3=CCCOC3)cc12 CHEMBL3359753 IC50 1.2 nM
NC1=N[C@@]2(CO1)c1cc(-c3cccnc3F)ccc1Oc1c2cc(-c2cccnc2F)nc1F CHEMBL3394215 IC50 1.2 nM
CC#Cc1cncc(-c2ccc3c(c2)C2(N=C(N)C(CC)=N2)[C@]2(CC[C@H](OC)CC2)C3)c1 CHEMBL3653723 IC50 1.2 nM
COc1nc(N2CC3[C@](c4cc(NC(=O)c5ccc(F)cn5)ccc4F)(C2)NC(=N)N(C)S3(=O)=O)nc(C)c1F CHEMBL4106980 Ki 1.2 nM
Cc1onc2c1CC1(CC2)Cc2ccc(-c3cccc(C#N)c3)cc2C12N=C(N)N(C)C2=O CHEMBL3896483 IC50 1.2 nM
NC1=NC2(CCO1)c1cc(NC(=O)c3ccc(F)cn3)ccc1Oc1c2cc(-c2ccnc(F)c2)nc1F CHEMBL3975637 IC50 1.2 nM
CN1C(=N)N[C@](C)(c2sc(-c3cc(F)cc(-c4nnco4)c3)cc2F)CS1(=O)=O CHEMBL3913634 Ki 1.2 nM
C[C@]1(c2cc(NC(=O)c3cnc(OCF)cn3)ccc2F)N=C(N)SCC12CC(F)(F)C2 CHEMBL4592239 IC50 1.2 nM
C[C@H]1SC(N)=N[C@](C)(c2cc(NC(=O)c3ccc(OC(F)F)cn3)ccc2F)[C@H]1F CHEMBL4561476 IC50 1.2 nM
COC[C@]12C[C@H]1[C@@](C)(c1cc(NC(=O)c3cnc(OCc4ncco4)cn3)cc(F)c1F)N=C(N)S2 CHEMBL4459222 IC50 1.2 nM
C[C@H]1OC[C@]2(c3cc(NC(=O)c4ccc(C#N)cn4)ccc3F)N=C(N)[C@](C)(C#N)C[C@H]12 CHEMBL4561901 IC50 1.26 nM
CN1C(=N)N[C@](C)(c2cc(NC(=O)c3ccc(C(F)(F)F)cn3)ccc2F)CS1(=O)=O CHEMBL3672917 Ki 1.261 nM
CC(C)[C@H](NC(=O)[C@@H](C[C@H](O)[C@H](COc1cc(F)cc(F)c1)NC(=O)c1cc(C(=O)N[C@H](C)c2ccccc2)cc(N(C)S(C)(=O)=O)c1)OCC1CC1)C(=O)NCc1ccccc1 CHEMBL591700 Ki 1.3 nM
CCC(C)[C@@]1(NC(C)=O)CCN([C@@H](CCc2ccccc2)C(=O)N[C@@H](Cc2cc(F)cc(F)c2)[C@H](O)[C@H]2C[C@@H](OCc3ccccn3)CN2)C1=O CHEMBL1916169 IC50 1.3 nM
NC1=N[C@@]2(CO1)c1cc(-c3cccnc3F)ccc1Oc1cnc(N3CCOCC3)cc12 CHEMBL3394046 IC50 1.3 nM
CC#Cc1cncc(-c2ccc3c(c2)[C@@]2(N=C(C)C(N)=N2)[C@]2(CC[C@H](O)CC2)C3)c1 CHEMBL3653726 IC50 1.3 nM
CC1=NC2(N=C1N)c1cc(-c3cc(Cl)cc(C#N)c3)ccc1C[C@]21CC[C@@H](OC(F)F)CC1 CHEMBL3639562 IC50 1.3 nM
C[C@@]1(c2cc(NC(=O)c3ccc(Cl)cn3)ccc2F)CS(=O)(=O)C2(CCCC2)C(=N)N1 CHEMBL3938241 Ki 1.3 nM
COc1cnc(C(=O)Nc2ccc3c(c2)C2(CCOC(N)=N2)c2cc(-c4cncc(F)c4)nc(F)c2O3)cn1 CHEMBL3910114 IC50 1.3 nM
Cc1cc(C#N)cnc1C(=O)Nc1ccc(F)c([C@]2(C)CS(=O)(=O)C3(CN(C)C3)C(=N)N2)c1 CHEMBL3922651 Ki 1.3 nM
CN1CC2(C1)C(=N)N[C@](C)(c1cc(NC(=O)c3ncc(C#N)cc3C3CC3)ccc1F)CS2(=O)=O CHEMBL3895721 Ki 1.3 nM
C[C@]1(c2cc(NC(=O)c3ccc(Cl)cn3)cc(F)c2F)N=C(N)S[C@@]2(CF)C[C@H]21 CHEMBL4539909 IC50 1.3 nM
CC1(c2cc(NC(=O)c3ccc(C#N)cn3)ccc2F)Cc2ccncc2C(N)=N1 CHEMBL4876909 IC50 1.3 nM
C[C@@]1(S(C)(=O)=O)CC[C@@](CF)(c2cc(NC(=O)c3cc4c(cn3)OC(F)(F)CO4)ccc2F)N=C1N CHEMBL5091877 IC50 1.3 nM
C[C@@]1(c2cc(NC(=O)c3ccc(C#N)cn3)ccc2F)Cn2cccc2C(N)=N1 CHEMBL3261075 pIC50 1.318 nM
Cc1cccc2nc(-c3ccc(OCCCN4C(=O)c5ccccc5C4=O)cc3)c(NC3CCCCC3)n12 CHEMBL4203158 Ki 1.37 nM
CCCO[C@H]1CN[C@@H]([C@@H](O)[C@H](Cc2cc(F)cc(F)c2)NC(=O)[C@H](CCc2ccccc2)N2CC[C@@](CC(C)C)(NC(C)=O)C2=O)C1 CHEMBL1915990 IC50 1.4 nM
CCC(C)[C@@]1(NC(C)=O)CCN([C@@H](CCc2ccccc2)C(=O)N[C@@H](Cc2cc(F)cc(F)c2)[C@H](O)[C@H]2C[C@@H](OCc3cccnc3)CN2)C1=O CHEMBL1916170 IC50 1.4 nM
CCC(C)[C@@]1(NC(C)=O)CCN([C@@H](CCc2ccccc2)C(=O)N[C@@H](Cc2cc(F)cc(F)c2)[C@H](O)[C@H]2C[C@@H](Oc3ccccc3)CN2)C1=O CHEMBL1916157 IC50 1.4 nM
CC#Cc1cccc(-c2ccc3c(c2)C2(N=C(C)C(N)=N2)[C@]2(CC[C@H](OC)CC2)C3)c1 CHEMBL2151058 IC50 1.4 nM
CC#Cc1cncc(-c2ccc3c(c2)C2(N=C(C)C(N)=N2)C2(CCC(OC)CC2)O3)c1 CHEMBL2152919 IC50 1.4 nM
NC1=N[C@@]2(CO1)c1cc(-c3cccnc3F)ccc1Oc1cnc(-c3ccccc3)cc12 CHEMBL3394052 IC50 1.4 nM
CN1C(=O)CC2(N=C1N)c1cc(-c3cccnc3F)ccc1Oc1c2cc(C2=CCCOC2)nc1F CHEMBL3695744 IC50 1.4 nM
CN1C(=O)C[C@]2(N=C1N)c1cc(-c3cccnc3F)ccc1Oc1c2cc(-c2ccnc(F)c2)nc1F CHEMBL3695747 IC50 1.4 nM
CN1C(=O)C2(N=C1N)c1cc(-c3cccnc3)ccc1CC21CCc2ccccc2CC1 CHEMBL3985866 IC50 1.4 nM
C#CCOc1cnc(C(=O)Nc2cc(F)c(F)c([C@]3(CF)C[C@@H](C(F)(F)F)OC(N)=N3)c2)cn1 CHEMBL3935940 IC50 1.4 nM
NC1=N[C@@]2(CCO1)c1cc(NC(=O)c3ccc(Cl)cn3)ccc1Oc1c2cc(C2=CCOCC2)nc1F CHEMBL3952809 IC50 1.4 nM
COc1ccc(C(=O)Nc2ccc3c(c2)C2(CCOC(N)=N2)c2cc(-c4cncc(F)c4)nc(F)c2O3)nc1 CHEMBL3908554 IC50 1.4 nM
Cc1cc(Br)cnc1C(=O)Nc1ccc2c(c1)C1(CCSC(N)=N1)c1cc(C3=CCOCC3)nc(F)c1O2 CHEMBL3917597 IC50 1.4 nM
CN1CC2(C1)C(=N)N[C@](C)(c1cc(NC(=O)c3ncc(C#N)cc3C(F)F)ccc1F)CS2(=O)=O CHEMBL3925463 Ki 1.4 nM
COc1ccc(C(=O)Nc2ccc(F)c([C@]3(C)CS(=O)(=O)C4(CN(c5ccc([N+](=O)[O-])cc5)C4)C(=N)N3)c2)nc1 CHEMBL3917788 Ki 1.4 nM
C[C@@]1(c2cc(NC(=O)c3ccc(OC(F)F)cn3)ccc2F)Cn2nc(C#N)cc2C(N)=N1 CHEMBL5093303 IC50 1.4 nM
NC1=N[C@@]2(CO1)c1cc(-c3cccnc3F)ccc1Oc1ncc(C3=CCOCC3)cc12 CHEMBL3359752 IC50 1.5 nM
Cc1cc(F)cnc1C(=O)Nc1ccc(F)c([C@]2(C)C[S@@]3(=O)=NCCCCN3C(N)=N2)c1 CHEMBL3742160 IC50 1.5 nM
CO[C@H]1CC[C@]2(CC1)Cc1ccc(-c3cc(C#N)cc(C(F)F)c3)cc1[C@@]21N=C(C)C(N)=N1 CHEMBL3955716 IC50 1.5 nM
COc1ccc(F)c(-c2ccc3c(c2)[C@@]2(N=C(C)C(N)=N2)[C@]2(CC[C@H](OC)CC2)C3)c1 CHEMBL3985518 IC50 1.5 nM
COC1CCC2(CC1)Cc1ccc(-c3cccc(Cl)c3)cc1C21N=C(N)N(C)C1=O CHEMBL3965117 IC50 1.5 nM
[C-]#[N+]c1ccc2c(c1)[C@@]1(N=C(C)C(N)=N1)[C@]1(CC[C@H](OC)[C@@H](C)C1)C2 CHEMBL3915375 IC50 1.5 nM
CO[C@H]1[C@H](C)C[C@@]2(Cc3ccc(-c4cncc(F)c4)cc3[C@@]23N=C(C)C(N)=N3)C[C@@H]1C CHEMBL3899867 IC50 1.5 nM
COc1ccc(C(=O)Nc2ccc3c(c2)[C@@]2(CCOC(N)=N2)c2cc(C4=CCOCC4)nc(F)c2O3)nc1 CHEMBL3948443 IC50 1.5 nM
COc1ccc(C(=O)Nc2ccc3c(c2)C2(CCSC(N)=N2)c2cc(C4=CCOCC4)nc(F)c2O3)nc1 CHEMBL3891240 IC50 1.5 nM
NC1=NC2(CCS1)c1cc(NC(=O)c3ccc(F)cn3)ccc1Oc1c2cc(-c2ccnc(F)c2)nc1F CHEMBL3908654 IC50 1.5 nM
[2H]C1([2H])OC(N)=N[C@]12c1cc(-c3cncnc3)ccc1C[C@@]21C[C@@H](C)[C@H](OC)[C@@H](C)C1 CHEMBL4085364 IC50 1.5 nM
C[C@]1(c2cc(NC(=O)c3cnc(OCF)cn3)ccc2F)N=C(N)O[C@H](CF)[C@@H]1F CHEMBL4227584 IC50 1.5 nM
C[C@]1(c2cc(NC(=O)c3ccc(C#N)cn3)ccc2F)N=C(N)O[C@@H]2CCC(F)(F)[C@@H]21 CHEMBL4462314 IC50 1.5 nM
C[C@H]1C[C@H]2CC(F)(F)C(N)=N[C@@]2(c2cc(NC(=O)c3cnc(OCF)cn3)ccc2F)CO1 CHEMBL4648883 IC50 1.5 nM
C[C@]1(c2cc(/C=C(\F)c3ccc(C#N)cn3)ccc2F)N=C(N)S[C@@]2(C(=O)N3CCOCC3)C[C@H]21 CHEMBL4760458 IC50 1.5 nM
CC1(c2cc(NC(=O)c3ccc(C#N)cn3)ccc2F)Cc2cnccc2C(N)=N1 CHEMBL4856179 IC50 1.5 nM
CC(C)C[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)C(NC(=O)[C@H](N)CCC(=O)O)C(C)C)[C@@H](O)C[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](CCC(=O)O)C(=O)NC(Cc1ccccc1)C(=O)O CHEMBL262295 Ki 1.6 nM
CC(C)C[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CCC(=O)O)C(C)C)C(=O)C(O)CN[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)O CHEMBL189141 Ki 1.6 nM
CC(C)C[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CCC(=O)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)O CHEMBL2372118 Ki 1.6 nM
CC(C)C[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CCC(=O)O)[C@@H](O)C[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)O CHEMBL2204316 IC50 1.6 nM
CC(C)C[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC(=O)O)C(C)C)[C@@H](O)C[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)O CHEMBL2019055 Ki 1.6 nM
CN1C(=O)[C@]2(N=C1N)c1cc(-c3cccnc3F)ccc1C[C@H]1CCOC[C@@H]12 CHEMBL3127069 IC50 1.6 nM
CC(C)C[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](NC(=O)[C@@H](N)CCC(=O)O)C(C)C)[C@@H](O)C[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](Cc1ccccc1)C(=O)O CHEMBL3361302 Ki 1.6 nM
CC#CCOc1cnc(C(=O)Nc2cc(F)c(F)c([C@@]3(CF)N=C(N)O[C@@H]4C[C@@H]43)c2)cn1 CHEMBL3683795 IC50 1.6 nM
C[C@@]1(c2cc(NC(=O)c3ccc(Cl)cn3)ccc2F)CS(=O)(=O)C2(CC2)C(=N)N1 CHEMBL3973607 Ki 1.6 nM
COc1cnc(C(=O)Nc2ccc3c(c2)C2(CCSC(N)=N2)c2cc(C4=CCOCC4)nc(F)c2O3)cn1 CHEMBL3917445 IC50 1.6 nM
NC1=NC2(CCO1)c1cc(NC(=O)c3ccc(F)cn3)ccc1Oc1c2cc(-c2cncc(F)c2)nc1F CHEMBL3913972 IC50 1.6 nM
NC1=NC2(CCO1)c1cc(NC(=O)c3ccc(Cl)cn3)ccc1Oc1cnc(-c3ccnc(F)c3)cc12 CHEMBL3902974 IC50 1.6 nM
CN1C(=N)N[C@](C)(c2sc(-c3cccc(-c4nnco4)c3)cc2Cl)CS1(=O)=O CHEMBL3985789 Ki 1.6 nM
COc1ccc(C(=O)Nc2ccc(F)c([C@]3(C)CS(=O)(=O)C4(CN(C(C)=O)C4)C(=N)N3)c2)nc1 CHEMBL3898071 Ki 1.6 nM
COc1cnc(C(=O)Nc2ccc(F)c([C@@]3(C)N=C(N)O[C@H](CF)[C@@H]3F)c2)cn1 CHEMBL4227313 IC50 1.6 nM
NC1=N[C@](CF)(c2cc(NC(=O)c3cnc(Cl)cn3)ccc2F)[C@@H]2C[C@]2(C(F)F)S1 CHEMBL4460912 IC50 1.6 nM
C[C@@]1(S(C)(=O)=O)CC[C@@](CF)(c2cc(NC(=O)c3ccc(OCF)cn3)ccc2F)N=C1N CHEMBL4565391 IC50 1.6 nM
C[C@@]1(c2cc(NC(=O)c3ncc(C#N)cc3Cl)ccc2F)C=CSC(N)=N1 CHEMBL3670318 IC50 1.6 nM
COc1cnc(C(=O)Nc2ccc(F)c([C@]3(C)CS(=O)(=O)N(C)C(=N)N3)c2)cn1 CHEMBL3672923 Ki 1.64 nM
COc1ccc(C(=O)N2Cc3ccc(N4C(=O)c5ccccc5C4=O)cc3CC2=O)cc1 CHEMBL5289994 IC50 1.69 nM
CC#Cc1cncc(-c2cc(Cl)c([C@]3(C)CC(=O)N(C)C(=N)N3)s2)c1 CHEMBL2151181 Ki 1.7 nM
C[C@]1(c2cc(NC(=O)c3ccc(C#N)cn3)ccc2F)N=C(N)O[C@@H]2CC(F)(F)C[C@@H]21 CHEMBL3261052 IC50 1.7 nM
CC(C)C[C@H](NC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)[C@@H](O)C[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)O)C(C)C CHEMBL3589002 Ki 1.7 nM
CC#CCOc1cnc(C(=O)Nc2ccc(Cl)c([C@@]3(C(F)F)N=C(N)O[C@@H]4C[C@@H]43)c2)cn1 CHEMBL3688646 IC50 1.7 nM
COC1CCC2(CC1)Cc1ccc(C#CC3CC3)cc1[C@]21N=C(N)N(C[C@@H]2CCCO2)C1=O CHEMBL3968186 IC50 1.7 nM
COc1cnc(C(=O)Nc2ccc3c(c2)C2(CCSC(N)=N2)c2cc(C4=CCOCC4)ncc2O3)cn1 CHEMBL3978732 IC50 1.7 nM
CN1C(=N)N[C@](C)(c2sc(-c3cccc(-c4nnco4)c3)cc2F)CS1(=O)=O CHEMBL3918648 Ki 1.7 nM
CN1C(=N)N[C@](C)(c2sc(-c3cccc(-c4cnco4)c3)cc2Cl)CS1(=O)=O CHEMBL3973797 Ki 1.7 nM
CN1C(=N)N[C@](C)(c2sc(-c3cc(-c4nnco4)ccc3F)cc2Cl)CS1(=O)=O CHEMBL3904651 Ki 1.7 nM
CN1CC2(C1)C(=N)N[C@](C)(c1cc(NC(=O)c3ccc(C#N)cn3)ccc1F)CS2(=O)=O CHEMBL3913535 Ki 1.7 nM
C[C@]1(c2cc(NC(=O)c3ncc(C#N)cc3Cl)ccc2F)N=C(N)O[C@H](CF)[C@@H]1F CHEMBL4227054 IC50 1.7 nM
C[C@]1(c2cc(NC(=O)c3cnc(OCF)cn3)ccc2F)N=C(N)SC[C@@H]1c1ccccc1 CHEMBL4473080 IC50 1.7 nM
C[C@@]1(c2cc(NC(=O)c3ccc(C#N)cn3)ccc2F)Cn2nc(C#N)cc2C(N)=N1 CHEMBL5084378 IC50 1.7 nM
Cc1nc(CNC(=O)c2cc(C(=O)N[C@@H](CC(C)C)[C@@H](O)C[C@@H](C)C(=O)N[C@H](C(=O)NC(C)C)C(C)C)cc(N(C)S(C)(=O)=O)c2)c(C)o1 CHEMBL376504 Ki 1.8 nM
COC(C)(C)COc1cnc2c(c1)[C@]1(COC(N)=N1)c1cc(-c3cccnc3F)ccc1O2 CHEMBL3359751 IC50 1.8 nM
COc1nc(N2C[C@H]3C(=O)N(C)C(N)=N[C@@]3(c3ccc(F)cc3F)C2)nc(OC)c1F CHEMBL3640257 Ki 1.8 nM
COc1cnc(C(=O)Nc2ccc3c(c2)C2(CCSC(N)=N2)c2cc(C4=CCCOC4)nc(F)c2O3)cn1 CHEMBL3968748 IC50 1.8 nM
COc1cnc(C(=O)Nc2ccc3c(c2)C2(CCOC(N)=N2)c2cc(-c4ccnc(F)c4)nc(F)c2O3)cn1 CHEMBL3890449 IC50 1.8 nM
NC1=N[C@@]2(CO1)c1cc(-c3cncc(C#CC4CC4)c3)ccc1Oc1cnc(C3=CCOCC3)cc12 CHEMBL4282964 IC50 1.8 nM
C[C@@]1(c2cc(NC(=O)c3cnc(OCF)cn3)ccc2F)CCSC(N)=N1 CHEMBL4568202 IC50 1.8 nM
C#CCOc1cnc(C(=O)Nc2cc(F)c(F)c([C@@]3(C)N=C(N)S[C@@]4(COC)C[C@H]43)c2)c(C)c1 CHEMBL4452318 IC50 1.8 nM
CCn1cc(C2(c3cccc(-c4cncc(C#N)c4)c3)N=C(N)c3c(F)cccc32)cc(C)c1=O CHEMBL2177302 IC50 1.84 nM
C[C@@]1(c2cc(NC(=O)c3nc4ccc(C#N)nc4s3)ccc2F)CO[C@@](C)(C(F)(F)F)C(N)=N1 CHEMBL4440268 IC50 1.88 nM
C#Cc1cc(F)cc(C[C@H](NC(=O)COC)[C@H](O)CN[C@H]2CC3(CCC3)Oc3ncc(CC(C)(C)C)cc32)c1 CHEMBL2181906 IC50 1.9 nM
COCC(=O)N[C@@H](Cc1cc(F)cc(-c2nccs2)c1)[C@H](O)CN[C@H]1CC2(CCC2)Oc2ncc(CC(C)(C)C)cc21 CHEMBL2181902 IC50 1.9 nM
CC(C)C[C@H](NC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)[C@@H](O)C[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(N)=O)C(C)C CHEMBL3589000 Ki 1.9 nM
CC[C@@H]1C[C@@]2(Cc3ccc(C#N)cc3[C@]23N=C(N)N(CC2COCCO2)C3=O)C[C@H](C)[C@H]1O CHEMBL3929995 IC50 1.9 nM
COC1CCC2(CC1)Cc1ccc(-c3cncc(F)c3)cc1C21N=C(N)N(C)C1=O CHEMBL3938174 IC50 1.9 nM
CC(F)(F)[C@H]1OC(N)=N[C@](C)(c2cc(NC(=O)c3cnc(OCF)cn3)ccc2F)[C@H]1F CHEMBL4226994 IC50 1.9 nM
C[C@]1(c2cc(NC(=O)c3cnc(OCF)cn3)ccc2F)N=C(N)SCC12CCS(=O)(=O)CC2 CHEMBL4465534 Ki 1.9 nM
COC[C@H]1C[C@@H]2[C@](c3cc(Oc4cc(C#N)ccn4)ccc3F)(CO1)N=C(N)N(C)S2(=O)=O CHEMBL4567636 Ki 1.9 nM
C[C@]1(c2cc(NC(=O)c3ccc(Cl)cn3)cc(F)c2F)N=C(N)S[C@@]2(C#N)C[C@H]21 CHEMBL4471141 IC50 1.9 nM
CSCC[C@H](NC(=O)[C@@H](NC(=O)OC(C)(C)C)C(C)C)C(=O)N[C@@H](CC(C)C)[C@@H](O)C[C@@H](C)C(=O)N[C@H](C(=O)NCc1ccccc1)C(C)C CHEMBL290001 IC50 2.0 nM
CCCN(CCC)C(=O)c1cc(C)cc(C(=O)N[C@@H](Cc2cc(F)cc(F)c2)[C@H](O)CNCc2cccc(CC)c2)c1 CHEMBL397275 IC50 2.0 nM
CC(C)S(=O)(=O)N(C)c1cc(C(=O)N[C@@H](Cc2ccccc2)[C@@H](N)CF)cc(NC[C@H]2C[C@@H]2C)n1 CHEMBL230245 IC50 2.0 nM
CCCC(CCC)S(=O)(=O)C[C@@H](NC(=O)c1cccc(O)c1)C(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)CNCc1cccc(CC)c1 CHEMBL266566 IC50 2.0 nM
CCCC(CCC)S(=O)(=O)C[C@@H](NC(=O)c1ccc(OC)cc1)C(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)CNCc1cccc(CC)c1 CHEMBL231861 IC50 2.0 nM
CCCCS(=O)(=O)C[C@@H](NC(=O)OCc1ccncc1)C(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)CNCc1cccc(CC)c1 CHEMBL409950 EC50 2.0 nM
CCCCS(=O)(=O)C[C@@H](NC(=O)OC)C(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)CNCc1cccc(CC)c1 CHEMBL393733 EC50 2.0 nM
CCCC(CCC)S(=O)(=O)C[C@@H](NC(=O)OC)C(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)CNCc1cccc(CC)c1 CHEMBL414145 EC50 2.0 nM
CN(c1cc2cc(c1)C(=O)N[C@@H](c1ccccc1)CCc1cccc(c1)C[C@@](C)(N)C(=O)OC2)S(C)(=O)=O CHEMBL400438 IC50 2.0 nM
CC1CC1CNc1cc(C(=O)N[C@@H](Cc2ccccc2)[C@@H](N)CCC(F)(F)F)cc(N(C)S(C)(=O)=O)n1 CHEMBL247416 IC50 2.0 nM
CCCN(c1cc2cc(c1)C(=O)N[C@@H](c1ccccc1)CCc1cccc(c1)C[C@@](C)(N)C(=O)OC2)S(C)(=O)=O CHEMBL400530 IC50 2.0 nM
CC(C)(C)c1cccc(CNC[C@@H](O)[C@H](Cc2cc(F)cc(F)c2)NC(=O)[C@@H]2CN(Cc3cc(F)cc(F)c3)C(=O)N2)c1 CHEMBL260621 Ki 2.0 nM
CCNc1cc(C(=O)N[C@@H](Cc2ccccc2)[C@H](O)CNCc2cccc(C(F)(F)F)c2)c(F)c(N2CCCCS2(=O)=O)c1 CHEMBL253641 IC50 2.0 nM
COC[C@H]1CCCN1C(=O)c1cncc(C(=O)N[C@@H](Cc2cc(F)cc(F)c2)[C@H](O)[C@@H]2NCCN(Cc3ccccc3)C2=O)c1 CHEMBL511110 IC50 2.0 nM
COC[C@H]1CCCN1C(=O)c1cc(C)cc(C(=O)N[C@@H](Cc2cc(F)cc(F)c2)[C@H](O)[C@@H]2NCN(Cc3ccccc3)C2=O)c1 CHEMBL451950 IC50 2.0 nM
CCc1cn2c3c(cc(C(=O)N[C@@H](Cc4ccccc4)[C@H](O)CNCc4cccc(C(F)(F)F)c4)cc13)N(C)S(=O)(=O)CC2 CHEMBL446972 IC50 2.0 nM
CCc1cn2c3c(cc(C(=O)N[C@@H](Cc4ccccc4)[C@H](O)CNCc4cccc(OC)c4)cc13)N(C)S(=O)(=O)CC2 CHEMBL539436 IC50 2.0 nM
CCc1cn2c3c(cc(C(=O)N[C@@H](Cc4ccccc4)[C@H](O)CNCc4cccc(C(F)(F)F)c4)cc13)N(C)S(=O)(=O)CC2 CHEMBL554349 IC50 2.0 nM
CCCN(CCC)C(=O)c1cc(C(=O)N[C@@H](Cc2cc(F)cc(F)c2)[C@H](O)CNCc2cccc(OC)c2)cc(C(C)O)c1 CHEMBL539973 IC50 2.0 nM
CC(C)c1ccc2c(c1)[C@@H](NC[C@@H](O)[C@@H]1C[C@H](C)CCCCCCCCC(=O)N(C)[C@@H](C)C(=O)N1)CC(C)(C)O2 CHEMBL558488 IC50 2.0 nM
CCCS(=O)(=O)N(C)c1cc2cc(c1)C(=O)N[C@H]([C@H](O)CNC1(c3cccc(C(C)C)c3)CC1)Cc1cccc(c1)OCCCCN2 CHEMBL595136 IC50 2.0 nM
COCCN(C[C@H]1C[C@@H]1C)c1cc(-c2nnc([C@](C)(N)Cc3ccc(F)cc3)o2)c(Cl)c(N(C)S(C)(=O)=O)n1 CHEMBL1087536 IP 2.0 nM
COC[C@H]1CCCN1C(=O)c1cc(C)cc(C(=O)N[C@@H](Cc2cc(F)cc(F)c2)[C@H](O)[C@H]2CN(S(=O)(=O)c3ccccn3)CCN2)c1 CHEMBL1097350 Ki 2.0 nM
COC[C@H]1CCCN1C(=O)c1cc(C)cc(C(=O)N[C@@H](Cc2cc(F)cc(F)c2)[C@H](O)[C@H]2CN(S(=O)(=O)c3cn(C)cn3)CCN2)c1 CHEMBL1097352 Ki 2.0 nM
CCC(C)[C@@]1(NC(C)=O)CCN([C@@H](CCc2ccccc2)C(=O)N[C@@H](Cc2cc(F)cc(F)c2)[C@H](O)CNCc2cccc(OC)c2)C1=O CHEMBL1914472 IC50 2.0 nM
CC(=O)N[C@@H](Cc1cccc(F)c1)[C@H](O)CN[C@H]1C[C@]2(C[C@@H](F)C2)Oc2ncc(CC(C)(C)C)cc21 CHEMBL2030994 IC50 2.0 nM
CC(=O)N[C@@H](Cc1cccc(F)c1)[C@H](O)CN[C@H]1C[C@]2(C[C@H](F)C2)Oc2ncc(CC(C)(C)C)cc21 CHEMBL2031145 IC50 2.0 nM
COCC(=O)N[C@@H](Cc1ccc(F)cc1)[C@H](O)CN[C@H]1C[C@]2(C[C@H](O)C2)Oc2ncc(CC(C)(C)C)cc21 CHEMBL2031149 IC50 2.0 nM
CC(C)(C)c1cccc(CN[C@H]2CS(=O)(=O)C[C@@H](Cc3cc(F)c(N)c(OC(C(F)(F)F)C(F)(F)F)c3)[C@@H]2O)c1 CHEMBL2048047 IC50 2.0 nM
CCOC[C@@H](Oc1cc(C[C@@H]2CS(=O)(=O)C[C@H](NCc3cccc(C(C)(C)C)c3)[C@H]2O)cc(F)c1N)C(F)(F)F CHEMBL2048051 IC50 2.0 nM
COC[C@@H](Oc1cc(C[C@@H]2CS(=O)(=O)C[C@H](NCc3cccc(C(C)(C)C)c3)[C@H]2O)cc(F)c1N)C(F)(F)F CHEMBL2048053 IC50 2.0 nM
CC(C)(O)c1cccc(CN[C@H]2CS(=O)(=O)C[C@@H](Cc3cc(F)c(N)c(OC(C(F)(F)F)C(F)(F)F)c3)[C@@H]2O)c1 CHEMBL2048058 IC50 2.0 nM
CC(C)(CO)c1cccc(CN[C@H]2CS(=O)(=O)C[C@@H](Cc3cc(F)c(N)c(OC(C(F)(F)F)C(F)(F)F)c3)[C@@H]2O)c1 CHEMBL2048059 IC50 2.0 nM
CC(=O)N[C@@H](Cc1ccc(F)c(F)c1)[C@H](O)CN[C@H]1CC2(CCC2)Oc2ncc(CC(C)(C)C)cc21 CHEMBL2151237 IC50 2.0 nM
CCn1cc([C@]2(c3cccc(-c4cncc(C#N)c4)c3)N=C(N)c3c(F)cccc32)cc(C)c1=O CHEMBL2152904 IC50 2.0 nM
CC#Cc1ccnc(-c2cccc([C@@]3(c4cc(C)c(=O)n(CC)c4)N=C(N)c4c(F)cccc43)c2)c1 CHEMBL2152906 IC50 2.0 nM
NC1=N[C@@]2(CCOC1)c1cc(-c3cccnc3F)ccc1Oc1cnc(-c3ccc(F)c(F)c3)cc12 CHEMBL2152912 IC50 2.0 nM
CC#Cc1cncc(-c2csc([C@]34CN(c5cccc(OC(C)C)c5)C[C@H]3C(=O)N(C)C(=N)N4)c2)c1 CHEMBL2178152 Ki 2.0 nM
CN1C(=N)N[C@@]2(c3cc(-c4ccc(F)c(C#N)c4)cs3)CN(C(=O)c3cccc(F)c3)C[C@H]2C1=O CHEMBL2178146 Ki 2.0 nM
C[C@@]1(c2cc(NC(=O)c3ccc(C#N)cn3)ccc2F)C[C@@H](C(F)(F)F)OC(N)=N1 CHEMBL2347208 IC50 2.0 nM
NC1=N[C@@]2(c3cccc(NC(=O)c4ccc(Cl)cn4)c3)C[C@H]2CCS1 CHEMBL2331708 IC50 2.0 nM
CCc1ccc2c(c1)[C@@H](NC[C@@H](O)[C@@H]1Cc3cccc(c3)CCCCn3cc(cc(N4CCCC4)c3=O)C(=O)N1)CC1(CCC1)O2 CHEMBL2407490 IC50 2.0 nM
CC(C)(C)c1cccc(CN[C@H]2C[S@+]([O-])C[C@@H](Cc3cc(F)c(N)c(OC(C(F)(F)F)C(F)(F)F)c3)[C@@H]2O)c1 CHEMBL2425608 IC50 2.0 nM
Cc1cc(C#N)cnc1C(=O)Nc1cc([C@]2(C)CO[C@@](C)(C(F)(F)F)C(N)=N2)c(F)cn1 CHEMBL3261068 IC50 2.0 nM
CC(C)(C)COc1ccc2c(c1)[C@]1(COC(N)=N1)c1cc(-c3cncnc3)ccc1O2 CHEMBL3354688 IC50 2.0 nM
CC(C)(C)C#Cc1ccc2c(c1)[C@]1(COC(N)=N1)c1cc(-c3cncnc3)ccc1O2 CHEMBL3354689 IC50 2.0 nM
CC(C)(O)C#Cc1ccc2c(c1)[C@]1(COC(N)=N1)c1cc(-c3cncnc3)ccc1O2 CHEMBL3354691 IC50 2.0 nM
CC(C)C[C@H](NC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)[C@@H](O)C[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(N)=O)C(C)C CHEMBL3588999 Ki 2.0 nM
CC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)[C@@H](O)C[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(N)=O)C(C)C CHEMBL3589001 Ki 2.0 nM
C[C@]1(c2cc(NC(=O)c3ccc(OC(F)F)cn3)ccc2F)N=C(N)OC[C@@H]1F CHEMBL3680858 IC50 2.0 nM
C[C@]1(c2cc(NC(=O)c3ncc(C#N)cc3Cl)ccc2F)N=C(N)OC[C@@H]1F CHEMBL3680859 IC50 2.0 nM
C[C@]1(F)COC(N)=N[C@]1(C)c1cc(NC(=O)c2ncc(Cl)cc2Cl)ccc1F CHEMBL3680890 IC50 2.0 nM
C[C@]1(c2cc(NC(=O)c3ncc(Cl)cc3F)ccc2F)N=C(N)OC[C@@H]1F CHEMBL3680860 IC50 2.0 nM
C[C@]1(F)COC(N)=N[C@]1(C)c1cc(NC(=O)c2nn(C(F)F)cc2Cl)ccc1F CHEMBL3680891 IC50 2.0 nM
C[C@]1(c2cc(NC(=O)c3ncc(C(F)(F)F)cc3Cl)ccc2F)N=C(N)OC[C@@H]1F CHEMBL3680861 IC50 2.0 nM
C[C@]1(c2cc(NC(=O)c3ccc(F)cn3)ccc2F)N=C(N)OC[C@@H]1OCC(F)(F)F CHEMBL3680896 IC50 2.0 nM
C[C@@]1(c2cc(NC(=O)c3ccc(C#N)cn3)ccc2F)C[S@]2(=O)=NCCCCN2C(N)=N1 CHEMBL3739843 IC50 2.0 nM
CN1C(=O)C[C@]2(N=C1N)c1cc(-c3cccnc3F)ccc1Oc1c2cc(C2CCOC(C)(C)C2)nc1F CHEMBL3695753 IC50 2.0 nM
COCCN1C(=O)[C@]2(N=C1N)c1cc(C#N)ccc1C[C@@]21CC[C@H](OC)[C@@H](C)C1 CHEMBL3658356 IC50 2.0 nM
COC1CCC2(CC1)Cc1ccc(C#CC3CC3)cc1C21N=C(N)N(Cc2ccccc2)C1=O CHEMBL3922032 IC50 2.0 nM
C#CCOc1cnc(C(=O)Nc2cc(F)c(F)c([C@]3(C)C[C@@H](C(F)(F)F)OC(N)=N3)c2)cn1 CHEMBL3964372 IC50 2.0 nM
O=C(NC1=N[C@](c2nc(NC(=O)c3ccc(Cl)cn3)ccc2F)(C(F)F)C[C@@H](C(F)(F)F)O1)c1ccccc1 CHEMBL3937600 IC50 2.0 nM
NC1=NC2(CCO1)c1cc(NC(=O)c3ccc(Cl)cn3)ccc1Oc1c2cc(C2=CCCOC2)nc1F CHEMBL3890269 IC50 2.0 nM
N#Cc1ccc(C(=O)Nc2ccc3c(c2)C2(CCOC(N)=N2)c2cc(C4=CCCOC4)nc(F)c2O3)nc1 CHEMBL3895059 IC50 2.0 nM
Cc1cn(C(F)F)nc1C(=O)Nc1csc([C@]23CO[C@@H](C)C[C@H]2CSC(N)=N3)n1 CHEMBL3980484 IC50 2.0 nM
NC1=N[C@@]2(COCC1)c1cc(-c3cccnc3F)ccc1Oc1cnc(-c3ccc(F)c(F)c3)cc12 CHEMBL3900160 IC50 2.0 nM
CNS1(O)C[C@@](C)(c2cc(NC(=O)c3ccc(F)cn3)ccc2F)NC(=N)N1C CHEMBL3903739 Ki 2.0 nM
C[C@@H](NC(=O)c1cc(C(=O)N[C@@H](Cc2ccccc2)[C@H](O)[C@@H]2NCCN(Cc3ccccc3)C2=O)cc(N(C)S(C)(=O)=O)c1)c1ccccc1 CHEMBL4081377 Ki 2.0 nM
CC(C)NCc1cc([C@]2(C)CCSC(N)=N2)c(F)cc1F CHEMBL4083698 IC50 2.0 nM
[2H]C1([2H])OC(N)=N[C@]12c1cc(-c3cncnc3)ccc1C[C@@]21CC[C@H](OC)[C@@H](CC)C1 CHEMBL4067413 IC50 2.0 nM
CN1C(=N)N[C@@]2(c3cc(-c4cc(F)cc(C#N)c4)cs3)CN(c3ncc(F)cn3)C[C@H]2C1=O CHEMBL4288644 Ki 2.0 nM
C[C@]1(c2cc(NC(=O)c3cnc(OCF)cn3)ccc2F)N=C(N)SC[C@H]1c1ccccc1 CHEMBL4463201 IC50 2.0 nM
C[C@]1(c2cc(NC(=O)c3cnc(OCF)cn3)ccc2F)N=C(N)SC[C@@H]1C1CCOCC1 CHEMBL4587362 IC50 2.0 nM
CC1(c2cc(NC(=O)c3ccc(C#N)cn3)ccc2F)Cc2ncc(F)cc2C(N)=N1 CHEMBL4438044 IC50 2.0 nM
Cc1cc(Cl)cnc1C(=O)Nc1ccc(F)c([C@@]2(C)N=C(N)[C@]3(C)CC[C@H]2S3(=O)=O)c1 CHEMBL4464845 IC50 2.0 nM
Cc1cc(C#N)cnc1C(=O)Nc1ccc(F)c([C@]2(C)CS3(=O)=NCCCCN3C(N)=N2)c1 CHEMBL4573881 IC50 2.0 nM
Cc1cc(Cl)cnc1C(=O)Nc1ccc2c(c1)[C@@]1(C)N=C(N)C(C)(C)S(=O)(=O)[C@@H]1CCO2 CHEMBL4450749 IC50 2.0 nM
C[C@]1(c2cc(NC(=O)c3ccc(Cl)cn3)cc(F)c2F)N=C(N)S[C@@]2(CO)C[C@H]21 CHEMBL4575752 IC50 2.0 nM
C[C@@]1(c2cc(NC(=O)c3cnc(C#N)cn3)ccc2F)C[S@@]2(=O)=NCC(F)(F)CN2C(N)=N1 CHEMBL4796231 IC50 2.0 nM
C[C@]1(c2cc(/C=C(\F)c3ccc(C#N)cn3)ccc2F)N=C(N)S[C@@]2(S(C)(=O)=O)C[C@H]21 CHEMBL4779386 IC50 2.0 nM
CNC(=O)[C@]12C[C@H]1[C@@](C)(c1cc(/C=C(\F)c3ccc(C#N)cn3)ccc1F)N=C(N)S2 CHEMBL4787115 IC50 2.0 nM
CN(C)C(=O)[C@]12C[C@H]1[C@@](C)(c1cc(/C=C(\F)c3ccc(C#N)cn3)ccc1F)N=C(N)S2 CHEMBL4790663 IC50 2.0 nM
C[C@@]1(S(C)(=O)=O)CC[C@@](CF)(c2cc(NC(=O)c3cnc(OCF)cn3)ccc2F)N=C1N CHEMBL5081571 IC50 2.0 nM
C[C@]1(CF)C(=N)N[C@](C)(c2nc(NC(=O)c3ccc(C#N)cn3)ccc2F)CS1(=O)=O CHEMBL5194897 Ki 2.0 nM
Cc1cc(C#N)cnc1C(=O)Nc1ccc(F)c([C@]2(C)CS(=O)(=O)[C@](C)(CF)C(=N)N2)n1 CHEMBL5203401 Ki 2.0 nM
C/C(=C\C1=CCN(C(=O)CCc2ccccc2)C(=O)C1)N1C(=O)c2ccccc2C1=O CHEMBL5267312 IC50 2.07 nM
CCO[C@H](C[C@H](O)[C@H](COc1cc(F)cc(F)c1)NC(=O)c1cc(C(=O)N[C@H](C)c2ccccc2)cc(N(C)S(C)(=O)=O)c1)C(=O)N[C@H](C(=O)NCc1ccccc1)C(C)C CHEMBL591699 Ki 2.1 nM
CCC(C)[C@@]1(NC(C)=O)CCN([C@@H](CCc2ccccc2)C(=O)N[C@@H](Cc2cc(F)cc(F)c2)[C@H](O)[C@H]2C[C@@H](Oc3ccccn3)CN2)C1=O CHEMBL1916158 IC50 2.1 nM
CC(=O)N[C@@H](Cc1ccc(F)c(OC(F)(F)F)c1)[C@H](O)CN[C@H]1CC2(CCC2)Oc2ncc(CC(C)(C)C)cc21 CHEMBL2151240 IC50 2.1 nM
NC1=NC(c2cccc(-c3cncnc3)c2)(c2ccnc(C(F)(F)F)c2)c2ccccc21 CHEMBL2177308 IC50 2.1 nM
COC1CCC2(CC1)Cc1ccc(C#CC3CC3)cc1C21N=C(N)N(C)C1=O CHEMBL3656184 IC50 2.1 nM
CO[C@H]1CC[C@]2(CC1)Cc1ccc(-c3cncc(C(F)(F)F)c3)cc1[C@@]21N=C(C)C(N)=N1 CHEMBL3939410 IC50 2.1 nM
C#CCOc1cnc(C(=O)Nc2cc(F)c(F)c([C@@]3(C(F)F)N=C(N)O[C@@H]4C[C@@H]43)c2)cn1 CHEMBL3683864 IC50 2.1 nM
COC1CCC2(CC1)Cc1ccc(OCC3CC3)cc1[C@]21N=C(N)N(C)C1=O CHEMBL4112850 IC50 2.1 nM
CN1C(=N)N[C@](C)(c2sc(-c3ccc(-c4ccccc4)[nH]3)cc2Cl)CS1(=O)=O CHEMBL3951262 Ki 2.1 nM
C[C@H](F)[C@H]1OC(N)=N[C@](C)(c2cc(NC(=O)c3cnc(OCF)cn3)ccc2F)[C@H]1F CHEMBL4225154 IC50 2.1 nM
COC[C@]12C[C@H]1[C@@](C)(c1cc(NC(=O)c3ccc(Cl)cn3)cc(F)c1F)N=C(N)S2 CHEMBL4456863 IC50 2.1 nM
COc1cc(-c2nc3ccc(Cl)cn3c2NC(C)(C)C)ccc1OCCCN1C(=O)c2ccccc2C1=O CHEMBL4212743 Ki 2.14 nM
C[C@@]1(c2cccc(NC(=O)c3ccc(C#N)cn3)c2)Cn2nccc2C(N)=N1 CHEMBL4521954 pIC50 2.188 nM
COC1CCC2(CC1)Cc1ccc(-c3cccc(OC(F)(F)F)c3)cc1C21N=C(N)N2CCON=C21 CHEMBL3673208 IC50 2.19 nM
NC1=N[C@@]2(CO1)c1cc(-c3cccnc3F)ccc1Oc1cnc([C@H]3CCCCO3)cc12 CHEMBL3394045 IC50 2.2 nM
CO[C@H]1CC[C@]2(CC1)Cc1ccc(C#CC3CC3)cc1C21N=C(C)C(N)=N1 CHEMBL2152916 IC50 2.2 nM
COc1cc(-c2ccc3c(c2)[C@@]2(N=C(C)C(N)=N2)[C@]2(CC[C@H](OC)CC2)C3)cc(C#N)c1F CHEMBL3929159 IC50 2.2 nM
COc1cc(C#N)cc(-c2ccc3c(c2)C2(N=C(C)C(N)=N2)[C@]2(CC[C@H](OC)CC2)C3)c1 CHEMBL3907727 IC50 2.2 nM
CC#CCOc1cnc(C(=O)Nc2ccc(F)c([C@@]3(CF)N=C(N)O[C@@H]4C[C@@H]43)c2)cn1 CHEMBL3688630 IC50 2.2 nM
C[C@@]1(c2cc(NC(=O)c3ccc(C(F)(F)F)cn3)ccc2F)CS(=O)(=O)C2(CCCC2)C(=N)N1 CHEMBL3986161 Ki 2.2 nM
COC1CCC2(CC1)Cc1ccc(C#CC3CCCC3)cc1C21N=C(N)N(C)C1=O CHEMBL3921357 IC50 2.2 nM
COC1CCC2(CC1)Cc1ccc(C#CC3CC3)cc1[C@]21N=C(N)N(C[C@H]2CCCO2)C1=O CHEMBL4115606 IC50 2.2 nM
COC1CCC2(CC1)Cc1ccc(C#CC3CC3)cc1[C@]21N=C(N)N(C)C1=O CHEMBL4110500 IC50 2.2 nM
CC1(C)Oc2ccc(NC(=O)c3ccc(Br)cn3)cc2[C@@]2(COC(N)=N2)C12COC2 CHEMBL3650846 IC50 2.2 nM
CN1CC2(C1)C(=N)N[C@](C)(c1cc(NC(=O)c3ccc(Cl)cn3)ccc1F)CS2(=O)=O CHEMBL3903468 Ki 2.2 nM
C[C@]1(c2cc(NC(=O)c3ccc(C#N)cn3)ccc2F)N=C(N)O[C@@H]2CCCC(F)(F)[C@@H]21 CHEMBL4574605 IC50 2.2 nM
CC(C)c1cccc(CNC[C@@H](O)[C@@H]2COC/C=C/CCNC(=O)c3cc(cc(N(C)S(C)(=O)=O)c3)C(=O)N2)c1 CHEMBL2047033 IC50 2.3 nM
NC1=N[C@@]2(CO1)c1cc(-c3cccnc3F)ccc1Oc1ncc(-c3ccnc(F)c3)cc12 CHEMBL3359759 IC50 2.3 nM
Cc1noc(C)c1[C@@H]1C[C@@](C)(c2cc(F)cc(NC(=O)c3ccc(Cl)cn3)c2)N=C(N)S1 CHEMBL3806215 IC50 2.3 nM
CC#Cc1ccnc(-c2ccc3c(c2)C2(N=C(C)C(N)=N2)[C@]2(CC[C@H](OC)CC2)C3)c1 CHEMBL3901045 IC50 2.3 nM
CO[C@H]1CC[C@]2(CC1)Cc1ccc(-c3cncc(Cl)c3)cc1C21N=C(C)C(N)=N1 CHEMBL3965844 IC50 2.3 nM
CC1(C)Oc2ccc(NC(=O)c3ncc(Cl)cc3F)cc2C2(COC(N)=N2)C12COC2 CHEMBL3703235 IC50 2.3 nM
C#CCOc1cnc(C(=O)Nc2ccc(F)c([C@]3(CF)C[C@@H](C(F)(F)F)OC(N)=N3)c2)cn1 CHEMBL3960610 IC50 2.3 nM
CC#CCOc1ccc(C(=O)Nc2ccc(F)c([C@]3(C)CS(=O)(=O)C4(CN(C)C4)C(=N)N3)c2)nc1 CHEMBL3923725 Ki 2.3 nM
CC#CCOc1ccc(C(=O)Nc2ccc(F)c([C@]3(C)CS(=O)(=O)C4(CCN(C)CC4)C(=N)N3)c2)nc1 CHEMBL3939487 Ki 2.3 nM
C[C@@]1(S(C)(=O)=O)CC[C@@](CF)(c2cc(NC(=O)c3cc4c(cn3)OCCO4)ccc2F)N=C1N CHEMBL5074678 IC50 2.3 nM
C[C@@]1(S(C)(=O)=O)CC[C@@](CF)(c2cc(NC(=O)c3cc4c(cn3)OCO4)ccc2F)N=C1N CHEMBL5084928 IC50 2.3 nM
NC1=N[C@@]2(c3cc(NC(=O)c4ccc(F)cn4)ccc3F)COC[C@H]2CS1 CHEMBL2396989 IC50 2.3 nM
C[C@@]1(c2cc(NC(=O)c3cnc(OCF)cn3)ccc2F)Cn2nc(C#N)cc2C(N)=N1 CHEMBL5082406 IC50 2.3 nM
CC#Cc1cncc(-c2cc(Cl)c([C@]3(C)CS(=O)(=O)N(C)C(=N)N3)s2)c1 CHEMBL3259832 Ki 2.387 nM
CC(=O)N[C@@H](Cc1cccc(C(F)(F)F)c1)[C@H](O)CN[C@H]1CC2(CCC2)Oc2ncc(CC(C)(C)C)cc21 CHEMBL2151235 IC50 2.4 nM
CC(=O)N[C@@H](Cc1ccc(F)c(C#N)c1)[C@H](O)CN[C@H]1CC2(CCC2)Oc2ncc(CC(C)(C)C)cc21 CHEMBL2151241 IC50 2.4 nM
Cc1cc(-c2cc3c(cn2)Oc2ccc(-c4cccnc4F)cc2[C@@]32COC(N)=N2)ccn1 CHEMBL3394056 IC50 2.4 nM
CN1C(=O)CC2(N=C1N)c1cc(-c3cccnc3F)ccc1Oc1c2cc(-c2ccnc(F)c2)nc1F CHEMBL3639946 IC50 2.4 nM
CO[C@H]1CC[C@]2(CC1)Cc1cc(F)c(-c3cc(Cl)cc(C#N)c3)cc1[C@@]21N=C(C)C(N)=N1 CHEMBL3902640 IC50 2.4 nM
CN1OC2(N=C1N)c1cc(C#CC3CC3)ccc1CC21CCC(OC(F)F)CC1 CHEMBL3962707 IC50 2.4 nM
CN1C(=O)[C@]2(N=C1N)c1cc(C#CC3CC3)ccc1C[C@]21CC[C@@H](OC(F)F)CC1 CHEMBL4113931 IC50 2.4 nM
NC1=NC2(CCO1)c1cc(NC(=O)c3ccc(Cl)cn3)ccc1Oc1c2cc(C2CC2)nc1F CHEMBL3905117 IC50 2.4 nM
CSCCC(NC(=O)[C@@H](NC(=O)OC(C)(C)C)C(C)C)C(=O)N[C@@H](CC(C)C)C(O)CC(C)C(=O)NC(C(=O)NCc1ccccc1)C(C)C CHEMBL293611 Ki 2.5 nM
CSCCC(NC(=O)[C@@H](NC(=O)OC(C)(C)C)C(C)C)C(=O)N[C@@H](CC(C)C)C(O)CC(C)C(=O)N[C@H](C(=O)NCc1ccccc1)C(C)C CHEMBL187614 Ki 2.5 nM
CC(C)c1cccc(CNC[C@H](O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCC[C@H](C(C)(C)N3CCCCC3=O)C2)c1 CHEMBL1077237 IC50 2.5 nM
Cc1ccccc1-c1ccc2nc(N)c(C[C@@H](C)C(=O)NCC3CCCCC3)cc2c1 CHEMBL1821815 IC50 2.5 nM
CCC(C)[C@@]1(NC(C)=O)CCN([C@@H](CCc2ccccc2)C(=O)N[C@@H](Cc2cc(F)cc(F)c2)[C@H](O)[C@H]2C[C@@H](Oc3cccnc3)CN2)C1=O CHEMBL1916159 IC50 2.5 nM
CCc1ccc2c(c1)[C@@H](NC[C@@H](O)[C@@H]1Cc3cccc(c3)CCCCn3cc(ccc3=O)C(=O)N1)CC1(CCC1)O2 CHEMBL2407488 IC50 2.5 nM
NC1=N[C@@]2(CO1)c1cc(-c3cccnc3F)ccc1Oc1cnc(-c3cccnc3)cc12 CHEMBL3394054 IC50 2.5 nM
NC1=N[C@@]2(CO1)c1cc(-c3cccnc3F)ccc1Oc1cnc(-c3ccncc3)cc12 CHEMBL3394055 IC50 2.5 nM
CO[C@H]1CC[C@]2(CC1)Cc1ccc(-c3ccc(F)c(C#N)c3)cc1[C@@]21N=C(C)C(N)=N1 CHEMBL3927408 IC50 2.5 nM
[C-]#[N+]c1ccc(C(=O)Nc2ccc(F)c([C@]3(C)C[C@@H](C(F)(F)F)OC(N)=N3)c2)nc1 CHEMBL3938934 IC50 2.5 nM
C#CCOc1cnc(C(=O)Nc2cnc(F)c([C@]3(C)C[C@@H](C(F)(F)F)OC(N)=N3)c2)cn1 CHEMBL3935512 IC50 2.5 nM
COc1ccc(C(=O)Nc2ccc3c(c2)C2(CCSC(N)=N2)c2cc(C4=CCCOC4)nc(F)c2O3)nc1 CHEMBL3950477 IC50 2.5 nM
CC1(C)C(=N)N[C@@]2(c3cc(NC(=O)c4ccc(Cl)cn4)ccc3F)COC[C@H]2S1(=O)=O CHEMBL4111708 Ki 2.5 nM
NC1=N[C@@]2(c3cc(NC(=O)c4cnc(OCF)cn4)ccc3F)CO[C@@H](CF)C[C@H]2CC1(F)F CHEMBL4636350 IC50 2.5 nM
CCCO[C@H]1CN[C@@H]([C@@H](O)[C@H](Cc2cc(F)cc(F)c2)NC(=O)[C@H](CCc2ccccc2)N2CC[C@](NC(C)=O)(C(C)CC)C2=O)C1 CHEMBL1915991 IC50 2.6 nM
NC1=N[C@]2(CO1)c1cc(C3=CCOCC3)ccc1Oc1ccc(-c3cccnc3F)cc12 CHEMBL3394058 IC50 2.6 nM
COC1CCC2(CC1)Cc1ccc(-c3cc(F)cc(Cl)c3)cc1C21N=C(N)N(C)O1 CHEMBL3652430 IC50 2.6 nM
CO[C@H]1CC[C@]2(CC1)Cc1ccc(-c3cc(C)cc(C#N)c3)cc1C21N=C(C)C(N)=N1 CHEMBL3895159 IC50 2.6 nM
C[C@@H]1C[C@@]2(Cc3ccc(-c4cncnc4)cc3[C@]23N=C(N)N(CC(C)(C)F)C3=O)C[C@H](C)[C@H]1O CHEMBL4112809 IC50 2.6 nM
COC1CCC2(CC1)Cc1ccc(-c3ccc(F)c(C#N)c3)cc1C21N=C(N)N(C)C1=O CHEMBL3897052 IC50 2.6 nM
COC1CCC2(CC1)Cc1ccc(-c3cncc(Cl)c3)cc1C21N=C(N)N(C)C1=O CHEMBL3975565 IC50 2.6 nM
NC1=NC2(CCS1)c1cc(NC(=O)c3ncc(Cl)cc3F)ccc1Oc1c2cc(C2=CCOCC2)nc1F CHEMBL3893104 IC50 2.6 nM
COc1cnc2c(Nc3ccc(F)c([C@]4(C)CS(=O)(=O)N(C)C(N)=N4)c3)nccc2c1 CHEMBL4451647 Ki 2.6 nM
C[C@@]1(c2cc(NC(=O)c3ccc(Cl)cn3)ccc2F)Cn2c(C#N)cnc2C(N)=N1 CHEMBL5075933 IC50 2.6 nM
Cc1cccn2c(NC3CCCCC3)c(-c3ccc(OCCCN4C(=O)c5ccccc5C4=O)cc3)nc12 CHEMBL4211862 Ki 2.62 nM
CCC(C)[C@@]1(NC(C)=O)CCN([C@@H](CCc2ccccc2)C(=O)N[C@@H](Cc2cc(F)cc(F)c2)[C@H](O)[C@H]2C[C@@H](OCc3cccc(C(F)(F)F)c3)CN2)C1=O CHEMBL1916166 IC50 2.7 nM
CC(C)(C)Cc1cnc2c(c1)[C@@H](NC[C@@H](O)[C@@H]1Cc3cccc(c3)CCCn3cc(ccc3=O)C(=O)N1)CC1(CCC1)O2 CHEMBL2407492 IC50 2.7 nM
NC1=N[C@@]2(CO1)c1cc(-c3cccnc3F)ccc1Oc1cnc(N3CC[C@H](F)C3)cc12 CHEMBL3394050 IC50 2.7 nM
COc1nc(N2C[C@H]3C(=O)N(C)C(N)=N[C@@]3(c3ccc(F)cc3F)C2)nc(C2CC2)c1F CHEMBL3640284 Ki 2.7 nM
CO[C@H]1CC[C@]2(CC1)Cc1ccc(C#CC3CCC3)cc1[C@]21N=C(C)C(N)=N1 CHEMBL4112651 IC50 2.7 nM
C[C@@H]1C[C@@]2(Cc3ccc(C#N)cc3[C@]23N=C(N)N(CC2(F)CCOCC2)C3=O)C[C@H](C)[C@H]1O CHEMBL4113868 IC50 2.7 nM
C#CCOc1cnc(C(=O)Nc2ccc(Cl)c([C@@]3(C(F)F)N=C(N)O[C@@H]4C[C@@H]43)c2)cn1 CHEMBL3688651 IC50 2.7 nM
C[C@@]1(c2cc(NC(=O)c3ncc(Cl)cc3Cl)ccc2F)CS(=O)(=O)C2(CCCC2)C(=N)N1 CHEMBL3985208 Ki 2.7 nM
NC1=NC2(CCO1)c1cc(NC(=O)c3ccc(Cl)cn3)ccc1Oc1ncc(C3=CCOCC3)cc12 CHEMBL3947677 IC50 2.7 nM
COc1cnc(C(=O)Nc2ccc3c(c2)C2(CCOC(N)=N2)c2cc(C4=CCCOC4)nc(F)c2O3)cn1 CHEMBL3966377 IC50 2.7 nM
CN1CC2(C1)C(=N)N[C@](C)(c1cc(NC(=O)c3ccc(OC(F)F)cn3)ccc1F)CS2(=O)=O CHEMBL3915968 Ki 2.7 nM
COc1cc(C#N)cc(-c2ccc3c(c2)[C@@]2(COC(N)=N2)[C@]2(CC[C@H](OC)CC2)C3)c1 CHEMBL4084381 IC50 2.7 nM
Cc1ccc2nc(-c3ccc(OCCCN4C(=O)c5ccccc5C4=O)cc3)c(NC3CCCCC3)n2c1 CHEMBL4210406 Ki 2.74 nM
COc1cc(-c2nc3ccccn3c2NC2CCCCC2)ccc1OCCCN1C(=O)c2ccccc2C1=O CHEMBL4214810 Ki 2.77 nM
COC(C)(C)C#Cc1cnc2c(c1)[C@]1(COC(N)=N1)c1cc(-c3cccnc3F)ccc1O2 CHEMBL3359761 IC50 2.8 nM
CO[C@H]1CC[C@]2(CC1)Cc1ccc(-c3cc(F)cc(F)c3)cc1[C@@]21N=C(C)C(N)=N1 CHEMBL3953357 IC50 2.8 nM
CN1C(=O)C[C@]2(N=C1N)c1cc(-c3cccnc3F)ccc1Oc1c2cc(C2=CCCOC2)nc1F CHEMBL3695749 IC50 2.8 nM
C#CCOc1cnc(C(=O)Nc2cc(F)c(Cl)c([C@@]3(CF)N=C(N)O[C@@H]4C[C@@H]43)c2)cn1 CHEMBL3688739 IC50 2.8 nM
COC1CCC2(CC1)Cc1ccc(-c3cncc(C(F)(F)F)c3)cc1C21N=C(N)N(C)C1=O CHEMBL3947870 IC50 2.8 nM
Cc1onc2c1CC1(CC2)Cc2ccc(C#CC3CC3)cc2C12N=C(N)N(C)C2=O CHEMBL3924839 IC50 2.8 nM
[C-]#[N+]c1ccc(C(=O)Nc2cc(F)c(F)c([C@]3(C)C[C@@H](C(F)(F)F)OC(N)=N3)c2)nc1 CHEMBL3903133 IC50 2.8 nM
COc1cnc(C(=O)Nc2ccc3c(c2)C2(CCSC(N)=N2)c2cc(-c4cncc(F)c4)nc(F)c2O3)cn1 CHEMBL3926305 IC50 2.8 nM
CN1C(=N)N[C@](C)(c2sc(-c3ccc(-c4nnco4)[nH]3)cc2Cl)CS1(=O)=O CHEMBL3971418 Ki 2.8 nM
[2H]C1([2H])Oc2cnc(C(=O)Nc3ccc(F)c([C@]4(CF)CC[C@@](C)(S(C)(=O)=O)C(N)=N4)c3)cc2OC1([2H])[2H] CHEMBL5083750 IC50 2.8 nM
C[C@@]1(c2cc(NC(=O)c3ccc(F)cn3)ccc2F)Cn2nc(C#N)cc2C(N)=N1 CHEMBL5085412 IC50 2.8 nM
C#Cc1ccc(F)c(C[C@H](NC(=O)COC)[C@H](O)CN[C@H]2CC3(CCC3)Oc3ncc(CC(C)(C)C)cc32)c1 CHEMBL2181907 IC50 2.9 nM
CCC1=NC2(N=C1N)c1cc(-c3cncc(Cl)c3)ccc1C[C@]21CC[C@@H](OC)CC1 CHEMBL3653722 IC50 2.9 nM
Cc1ccc(-c2cc(F)c3c(c2)[C@@]2(N=C(N)N(C)C2=O)c2cc(-c4cccc(Cl)c4)ccc2O3)cc1 CHEMBL3695733 IC50 2.9 nM
COC1CCC2(CC1)Cc1ccc(-c3cccnc3F)cc1C21N=C(N)N(C)C1=O CHEMBL3968709 IC50 2.9 nM
COc1cnc(C(=O)Nc2ccc3c(c2)C2(CCOC(N)=N2)c2cc(-c4ccnc(F)c4)ncc2O3)cn1 CHEMBL3962966 IC50 2.9 nM
Cc1cc(Cl)cnc1C(=O)Nc1ccc2c(c1)C1(CCSC(N)=N1)c1cc(C3=CCOCC3)nc(F)c1O2 CHEMBL3937966 IC50 2.9 nM
[2H]C1([2H])OC(N)=N[C@]12c1cc(-c3cc(C#N)cc(OC)c3)ccc1C[C@]21CC[C@@H](OC)CC1 CHEMBL4100832 IC50 2.9 nM
Cc1cc(OC(F)F)cnc1C(=O)Nc1csc([C@]23CO[C@@H](C)C[C@H]2CSC(N)=N3)n1 CHEMBL3972449 IC50 2.9 nM
COc1cnc(C(=O)Nc2ccc(F)c([C@]3(C)Cn4nc(C#N)cc4C(N)=N3)c2)cn1 CHEMBL5074068 IC50 2.9 nM
COc1c(C)cc(C2(c3cccc(-c4cncnc4)c3)N=C(N)c3c(F)cccc32)nc1C CHEMBL2177917 IC50 2.92 nM
COc1ccccc1C(=O)N1Cc2ccc(N3C(=O)c4ccccc4C3=O)cc2CC1=O CHEMBL5277927 IC50 2.96 nM
CC#Cc1cncc(-c2cccc(C3(c4ccnc(C(F)F)c4)N=C(N)c4c(F)cccc43)c2)c1 CHEMBL2177915 IC50 2.97 nM
CCCC(CCC)S(=O)(=O)C[C@@H](NC(=O)OCc1ccncc1)C(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)CNCc1cccc(CC)c1 CHEMBL394270 IC50 3.0 nM
CCCC(CCC)S(=O)(=O)C[C@@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)CNCc1cccc(CC)c1 CHEMBL231863 IC50 3.0 nM
CCNc1cc(C(=O)N[C@@H](Cc2ccccc2)[C@H](O)CNCc2cccc(C(F)(F)F)c2)cc(N2CCCCS2(=O)=O)c1 CHEMBL401473 IC50 3.0 nM
CCCN(CCC)C(=O)c1cc(C)cc(C(=O)N[C@@H](Cc2cc(F)cc(F)c2)[C@H](O)[C@H]2C[C@@H](Oc3ccccc3)CN2)c1 CHEMBL403727 IC50 3.0 nM
CCCCN1CC(C(=O)N[C@@H](Cc2cc(F)cc(F)c2)[C@H](O)[C@@H]2NCCN(Cc3ccccc3)C2=O)[C@@H](CC)C1=O CHEMBL454795 IC50 3.0 nM
CCCN(CCC)C(=O)c1cc(C)cc(C(=O)N[C@@H](Cc2cc(F)cc(F)c2)[C@H](O)[C@@H]2NCCN(Cc3ccccc3)C2=O)c1 CHEMBL509210 IC50 3.0 nM
CCNc1cc(C(=O)N[C@@H](Cc2ccccc2)[C@H](O)CNCc2cccc(C(F)(F)F)c2)cc(N2CCCCS2(=O)=O)c1 CHEMBL504438 IC50 3.0 nM
CCn1cc2c3c(cc(C(=O)N[C@@H](Cc4ccccc4)[C@H](O)CNCCC(F)(F)F)cc31)N(C)S(=O)(=O)CC2 CHEMBL564530 IC50 3.0 nM
CCCN(CCC)C(=O)c1cc(C(=O)N[C@@H](Cc2cc(F)cc(F)c2)[C@H](O)CNCc2cccc(OC)c2)cc(/C(C)=N\O)c1 CHEMBL540729 IC50 3.0 nM
CCCO[C@H](C[C@H](O)[C@H](COc1cc(F)cc(F)c1)NC(=O)c1cc(C(=O)N[C@H](C)c2ccccc2)cc(N(C)S(C)(=O)=O)c1)C(=O)N[C@H](C(=O)NCc1ccccc1)C(C)C CHEMBL591491 Ki 3.0 nM
CCCN(CCC)C(=O)c1cc(C)cc(C(=O)N[C@@H](Cc2cc(F)cc(F)c2)[C@H](O)[C@H]2CN(S(=O)(=O)c3ccccc3)CCN2)c1 CHEMBL1097319 Ki 3.0 nM
CCCN(CCC)C(=O)c1cc(C)cc(C(=O)N[C@@H](Cc2cc(F)cc(F)c2)[C@H](O)[C@H]2CN(S(=O)(=O)c3cnc(C)n3C)CCN2)c1 CHEMBL1097331 Ki 3.0 nM
COC[C@H]1CCCN1C(=O)CCCC(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)[C@H]1CN(S(=O)(=O)c2cccc(C)c2)CCN1 CHEMBL1097343 Ki 3.0 nM
CCNc1cc(C(=O)N[C@@H](Cc2ccccc2)[C@H](O)CN[C@@H](C)C(=O)NC2CCCCC2)cc(N(c2ccccc2)S(C)(=O)=O)c1 CHEMBL1210359 IC50 3.0 nM
CCOc1cc(C(=O)N[C@@H](Cc2ccccc2)[C@H](O)CNCc2cccc(C(F)(F)F)c2)cc(N(c2ccccc2)S(C)(=O)=O)c1 CHEMBL1210360 IC50 3.0 nM
CCC(C)[C@@]1(NC(C)=O)CCN([C@@H](CCc2ccccc2)C(=O)N[C@@H](Cc2cc(F)cc(F)c2)[C@H](O)[C@H]2C[C@@H](OCc3cccc(C#N)c3)CN2)C1=O CHEMBL1916167 IC50 3.0 nM
CCC(C)[C@@]1(NC(C)=O)CCN([C@@H](CCc2ccccc2)C(=O)N[C@@H](Cc2cc(F)cc(F)c2)[C@H](O)[C@H]2C[C@@H](S(=O)(=O)Cc3ccc(F)cc3)CN2)C1=O CHEMBL1914607 IC50 3.0 nM
CC(=O)N[C@@H](Cc1ccc(F)cc1)[C@H](O)CN[C@H]1C[C@]2(C[C@H](O)C2)Oc2ncc(CC(C)(C)C)cc21 CHEMBL2031148 IC50 3.0 nM
C[C@@H](Oc1cc(C[C@@H]2CS(=O)(=O)C[C@H](NCc3cccc(C(C)(C)C)c3)[C@H]2O)cc(F)c1N)C(F)(F)F CHEMBL2048050 IC50 3.0 nM
NC1=N[C@@]2(CCOC1)c1cc(-c3cccnc3F)ccc1Oc1cnc(C3CCC(F)(F)C3)cc12 CHEMBL2152913 IC50 3.0 nM
COc1cccnc1N1C[C@H]2C(=O)N(C)C(=N)N[C@@]2(c2cc(-c3cccc(C#N)c3)cs2)C1 CHEMBL2178712 Ki 3.0 nM
CN1C(=N)N[C@@]2(c3cc(-c4cccc(C#N)c4)cs3)CN(C(=O)c3ccccc3)C[C@H]2C1=O CHEMBL2178145 Ki 3.0 nM
CC(=O)N[C@@H](Cc1ccccc1)[C@H](O)CN[C@H]1CC2(CCC2)Oc2ncc(CC(C)(C)C)cc21 CHEMBL2151151 IC50 3.0 nM
C[C@@]1(c2cc(NC(=O)c3ccc(Cl)cn3)ccc2F)COCC(N)=N1 CHEMBL2403769 IC50 3.0 nM
CC(C)C[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CCC(=O)O)C(C)C)C(=O)N[C@@H](C)CN[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)O CHEMBL2443369 IC50 3.0 nM
CN1C(=N)N[C@](CCC2CCCCC2)(C[C@H]2CCC[C@@H](NC(=O)Nc3ccc(C#N)cc3)C2)C1=O CHEMBL3354260 Ki 3.0 nM
CC(C)(C)COc1ccc2c(c1)[C@]1(COC(N)=N1)c1cc(-c3cncc(C#N)c3)ccc1O2 CHEMBL3354706 IC50 3.0 nM
NC1=N[C@@]2(CO1)c1cc(-c3cccnc3F)ccc1Oc1c(F)cc(C3=CCCOC3)cc12 CHEMBL3354717 IC50 3.0 nM
Cn1cc(-c2cc(F)c3c(c2)[C@]2(COC(N)=N2)c2cc(-c4cccnc4F)ccc2O3)cn1 CHEMBL3354721 IC50 3.0 nM
C[C@H]1SC(N)=N[C@@]2(c3ccc(F)cc3F)CO[C@@H](c3cnn(C)c3)C[C@@H]12 CHEMBL3422243 IC50 3.0 nM
Cc1cc([C@H]2C[C@H]3CSC(N)=N[C@@]3(c3ccc(F)cc3F)CO2)on1 CHEMBL3422237 IC50 3.0 nM
C[C@]1(F)COC(N)=N[C@]1(C)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F CHEMBL3680892 IC50 3.0 nM
C[C@]1(c2cc(NC(=O)c3ccc(C(F)F)cn3)ccc2F)N=C(N)OC[C@@H]1F CHEMBL3680863 IC50 3.0 nM
C[C@]1(c2cc(NC(=O)c3ncc(Cl)cc3Cl)ccc2F)N=C(N)OC[C@@H]1OCC(F)(F)F CHEMBL3680898 IC50 3.0 nM
C#CCOc1cnc(C(=O)Nc2ccc(F)c([C@]3(C(F)F)COCC(N)=N3)c2)cn1 CHEMBL3653490 IC50 3.0 nM
Cc1ccc(C(=O)Nc2ccc(F)c([C@]3(C)CS(=O)(=O)N(C)C(=N)N3)c2)nc1 CHEMBL3672920 Ki 3.0 nM
CO[C@H]1[C@H](C)C[C@@]2(Cc3ccc(C#N)cc3[C@]23N=C(N)N(C2COC2)C3=O)C[C@@H]1C CHEMBL4112862 IC50 3.0 nM
CC1=N[C@]2(N=C1N)c1cc(OCCCF)ccc1C[C@]21CC[C@@H](OC(F)F)CC1 CHEMBL3672695 IC50 3.0 nM
C[C@@H]1C[C@@]2(Cc3ccc(C#N)cc3[C@]23N=C(N)N(CC(C)(C)Cl)C3=O)C[C@H](C)[C@H]1O CHEMBL4108836 IC50 3.0 nM
CN1C(=O)C2(N=C1N)c1cc(C#CC3CC3)ccc1CC21CCC(O)CC1 CHEMBL3921080 IC50 3.0 nM
CC#CCOc1ccc(C(=O)Nc2cc(F)c(F)c([C@]3(C)C[C@@H](C(F)(F)F)OC(N)=N3)c2)nc1 CHEMBL3924515 IC50 3.0 nM
C[C@@]1(c2cc(NC(=O)c3cnc(OCc4ncco4)cn3)cc(F)c2F)C[C@@H](C(F)(F)F)OC(N)=N1 CHEMBL3955255 IC50 3.0 nM
COc1cnc(C(=O)Nc2cc(Cl)c(F)c([C@]3(C)C[C@@H](C(F)(F)F)OC(N)=N3)c2)cn1 CHEMBL3966981 IC50 3.0 nM
Cc1ccc(C(=O)Nc2ccc3c(c2)[C@@]2(CCOC(N)=N2)c2cc(C4=CCCOC4)ncc2O3)nc1 CHEMBL3893463 IC50 3.0 nM
NC1=NC2(CCO1)c1cc(NC(=O)c3ccc(Cl)cn3)ccc1Oc1cnc(C3=CCCOC3)cc12 CHEMBL3899000 IC50 3.0 nM
C[C@H]1C[C@H]2CSC(N)=N[C@@]2(c2nc(NC(=O)c3ccc(OC(F)F)cn3)ccc2F)CO1 CHEMBL3942279 IC50 3.0 nM
NC1=N[C@@]2(COCC1)c1cc(-c3cccnc3F)ccc1Oc1cnc(N3CCC(F)(F)C3)cc12 CHEMBL3921286 IC50 3.0 nM
CC1(C)C(=N)N[C@@]2(c3cc(NC(=O)c4ncc(Cl)cc4F)ccc3F)COC[C@H]2S1(=O)=O CHEMBL4108212 Ki 3.0 nM
CC1(C)C(=N)N[C@@]2(c3cc(NC(=O)c4ccc(OCF)cn4)ccc3F)COC[C@H]2S1(=O)=O CHEMBL4107721 Ki 3.0 nM
CC1(C)C(=N)N[C@@]2(c3cc(NC(=O)c4ccc(C(F)(F)F)cn4)ccc3F)COC[C@H]2S1(=O)=O CHEMBL4108059 Ki 3.0 nM
CC1(C)C(=N)N[C@@]2(c3cc(NC(=O)c4ccc(F)cn4)ccc3F)COC(CF)[C@H]2S1(=O)=O CHEMBL4112004 Ki 3.0 nM
COc1ccc(C(=O)Nc2ccc(F)c([C@]34COC(CF)[C@H]3S(=O)(=O)C(C)(C)C(=N)N4)c2)nc1 CHEMBL4112582 Ki 3.0 nM
CNS1(O)C[C@@](C)(c2cc(NC(=O)c3ccc(Cl)cn3)ccc2F)NC(=N)C1(C)C CHEMBL3956676 Ki 3.0 nM
CC1(C)C(=N)N[C@](C)(c2cc(NC(=O)c3ccc(Cl)cn3)ccc2F)CS1(O)NCC1CC1 CHEMBL3960086 Ki 3.0 nM
CC1(C)C(=N)N[C@](C)(c2cc(NC(=O)c3ccc(Cl)cn3)ccc2F)CS1(O)NCCF CHEMBL3939154 Ki 3.0 nM
COCCNS1(O)C[C@@](C)(c2cc(NC(=O)c3ccc(Cl)cn3)ccc2F)NC(=N)C1(C)C CHEMBL3933652 Ki 3.0 nM
CNS1(O)C[C@@](C)(c2cc(NC(=O)c3ccc(OC)cn3)ccc2F)NC(=N)N1C CHEMBL3889548 Ki 3.0 nM
COc1cnc(C(=S)Nc2ccc(F)c([C@]3(C)CS(=O)(=O)N(C)C(=N)N3)c2)cn1 CHEMBL3910526 Ki 3.0 nM
CN1C(=N)N[C@@]2(c3cc(NC(=O)c4ccc(Cl)cn4)ccc3F)CCC[C@H]2S1(=O)=O CHEMBL4127711 Ki 3.0 nM
NC1=N[C@@](c2cc(NC(=O)c3ccc(Br)cn3)ccc2F)(C(F)F)COC1 CHEMBL3653445 IC50 3.0 nM
Cc1cc(C#N)cnc1C(=O)Nc1ccc(F)c([C@]2(C)COC(CF)(CF)C(N)=N2)c1 CHEMBL4127572 IC50 3.0 nM
C[C@]1(c2cc(NC(=O)c3cnc(OCF)cn3)ccc2F)N=C(N)O[C@H](C2(F)CC2)[C@@H]1F CHEMBL4227851 IC50 3.0 nM
CN1C(=N)N[C@@]2(c3cc(-c4cccc(C#N)c4)cs3)CN(c3ncc(F)c(N4CCCC4)n3)C[C@H]2C1=O CHEMBL4285940 Ki 3.0 nM
C#CCOc1cnc(/C(F)=C/c2ccc(F)c([C@]3(C)CS(=O)(=O)N(C)C(N)=N3)c2)cn1 CHEMBL4440849 IC50 3.0 nM
CN1C(N)=N[C@](C)(c2cc(NC(=O)c3ccc(C#N)cn3)ccc2F)C2(CC2)S1(=O)=O CHEMBL4474110 Ki 3.0 nM
CC1(C)C(N)=N[C@@]2(CCOc3ccc(NC(=O)c4ccc(C#N)cn4)cc32)CS1(=O)=O CHEMBL4449989 Ki 3.0 nM
CN=[S@@]1(=O)C[C@@](C)(c2cc(NC(=O)c3ccc(Cl)cn3)ccc2F)N=C(N)C1(C)C CHEMBL4473638 Ki 3.0 nM
C[C@H]1C[C@H]2CSC(N)=N[C@@]2(c2cc(NC(=O)c3ccc(OC(F)F)cn3)ccc2F)CO1 CHEMBL4483673 IC50 3.0 nM
NC1=N[C@@]2(CO1)c1cc(-c3cccnc3F)ccc1Oc1c2cc(C2=CCCOC2)nc1F CHEMBL4564735 IC50 3.0 nM
C[C@@]1(S(C)(=O)=O)CC[C@@](CF)(c2cc(NC(=O)c3ccc(F)cn3)ccc2F)N=C1N CHEMBL5074719 IC50 3.0 nM
COc1cnc(C(=O)Nc2ccc(F)c([C@]3(C)CS(=O)(=O)[C@@](C)(C(F)F)C(=N)N3)c2)cn1 CHEMBL5203915 Ki 3.0 nM
C[C@@]1(c2nc(NC(=O)c3ccc(C#N)cn3)ccc2F)CS(=O)(=O)[C@](C)(CF)C(=N)N1 CHEMBL5170892 Ki 3.0 nM
C[C@@]1(c2nc(NC(=O)c3ccc(C#N)cn3)ccc2F)CS(=O)(=O)[C@@](C)(C(F)F)C(=N)N1 CHEMBL5204704 Ki 3.0 nM
Cc1cc(C#N)cnc1C(=O)Nc1ccc(F)c([C@]2(C)CS(=O)(=O)[C@](C)(C(F)F)C(=N)N2)n1 CHEMBL5195553 Ki 3.0 nM
COCCO[C@H](C[C@H](O)[C@H](COc1cc(F)cc(F)c1)NC(=O)c1cc(C(=O)N[C@H](C)c2ccccc2)cc(N(C)S(C)(=O)=O)c1)C(=O)N[C@H](C(=O)NCc1ccccc1)C(C)C CHEMBL591644 Ki 3.1 nM
CC(C)[C@H](NC(=O)[C@H](C)C[C@H](O)[C@H](COc1cc(F)cc(F)c1)NC(=O)c1cc(C(=O)N[C@H](C)c2ccccc2)cc(N(C)S(C)(=O)=O)c1)C(=O)NCc1ccccc1 CHEMBL1076905 IC50 3.1 nM
CC(C)(C)CCc1ccc2c(c1)[C@]1(COC(N)=N1)c1cc(-c3cncnc3)ccc1O2 CHEMBL3354690 IC50 3.1 nM
CO[C@H]1CC[C@]2(CC1)Cc1ccc(-c3cc(C#N)cc(C(F)(F)F)c3)cc1[C@@]21N=C(C)C(N)=N1 CHEMBL3971150 IC50 3.1 nM
COCc1cc(C#N)cc(-c2ccc3c(c2)C2(N=C(C)C(N)=N2)[C@]2(CC[C@H](OC)CC2)C3)c1 CHEMBL3657420 IC50 3.1 nM
C[C@@]1(c2cc(NC(=O)c3ccc(F)cn3)ccc2F)CS(=O)(=O)C2(CCCC2)C(=N)N1 CHEMBL3936864 Ki 3.1 nM
COc1cnc(C(=O)Nc2ccc3c(c2)[C@@]2(COC(N)=N2)C2(COC2)C(C)(C)O3)cn1 CHEMBL3650847 IC50 3.1 nM
COc1cnc(C(=O)Nc2ccc3c(c2)[C@@]2(COC(N)=N2)C2(CC2)C(C)(C)O3)cn1 CHEMBL3650850 IC50 3.1 nM
COc1cnc(C(=O)Nc2ccc3c(c2)C2(CCSC(N)=N2)c2cc(C4=CCCOC4)ncc2O3)cn1 CHEMBL3984506 IC50 3.1 nM
COc1cnc(C(=O)Nc2ccc3c(c2)C2(CCSC(N)=N2)c2cc(-c4ccnc(F)c4)nc(F)c2O3)cn1 CHEMBL3894188 IC50 3.1 nM
C[C@@H](O)C(=O)N[C@@H](Cc1cccc(-c2nccs2)c1)[C@H](O)CN[C@H]1CC2(CCC2)Oc2ncc(CC(C)(C)C)cc21 CHEMBL2181917 IC50 3.2 nM
N/C1=N\C(=O)[C@@H]2CCCN2c2ccc(cc2)OCCCCCCNCC(=O)Nc2c(Cl)cc(cc2Cl)CN1 CHEMBL3628128 Ki 3.2 nM
CC1=N[C@]2(N=C1N)c1cc(-c3cc(Cl)cc(C#N)c3)ccc1C[C@]21CC[C@@H](O)CC1 CHEMBL3672698 IC50 3.2 nM
Cc1cc(Cl)cnc1C(=O)Nc1ccc2c(c1)C1(COC(N)=N1)C1(COC1)C(C)(C)O2 CHEMBL3650826 IC50 3.2 nM
CC(C)[C@H](NC(=O)[C@@H](N)CNC(=O)c1nn[nH]n1)C(=O)N[C@@H](CC1CCCCC1)C(=O)N[C@@H](Cc1ccccc1)[C@@H](O)C(=O)Nc1cccc(-c2nn[nH]n2)c1 CHEMBL411711 IC50 3.3 nM
C=CCO[C@H](C[C@H](O)[C@H](COc1cc(F)cc(F)c1)NC(=O)c1cc(C(=O)N[C@H](C)c2ccccc2)cc(N(C)S(C)(=O)=O)c1)C(=O)N[C@H](C(=O)NCc1ccccc1)C(C)C CHEMBL591478 Ki 3.3 nM
NC1=N[C@@]2(CO1)c1cc(-c3cccnc3F)ccc1Oc1ncc(N3CCOCC3)cc12 CHEMBL3359756 IC50 3.3 nM
Cc1cc(Cl)cnc1C(=O)Nc1ccc(F)c([C@@]2(C)N=C(N)CO[C@@H]2F)c1 CHEMBL3634341 IC50 3.3 nM
COc1cccc(-c2ccc3c(c2)[C@@]2(N=C(C)C(N)=N2)[C@]2(CC[C@H](OC)CC2)C3)c1F CHEMBL3916726 IC50 3.3 nM
CO[C@H]1CC[C@]2(CC1)Cc1ccc(-c3cc(C#N)ccc3F)cc1[C@@]21N=C(C)C(N)=N1 CHEMBL3894452 IC50 3.3 nM
COC1CCC2(CC1)Cc1ccc(-c3cccnc3)cc1C21N=C(N)N(C)C1=O CHEMBL3977126 IC50 3.3 nM
CN1C(=N)N[C@](C)(c2sc(-c3cccc(-c4cnco4)c3)cc2F)CS1(=O)=O CHEMBL3949670 Ki 3.3 nM
CN1C(=N)N[C@](C)(c2sc(-c3cccc(-c4ncon4)c3)cc2Cl)CS1(=O)=O CHEMBL3939857 Ki 3.3 nM
CN1CC2(C1)C(=N)N[C@](C)(c1cc(NC(=O)c3ccc(OC(F)(F)F)cn3)ccc1F)CS2(=O)=O CHEMBL3940488 Ki 3.3 nM
CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)CNC(=O)O)C(C)C)C(=O)N[C@@H](Cc1ccccc1)[C@@H](O)C(=O)Nc1cc(C(=O)O)cc(C(=O)O)c1 CHEMBL288713 IC50 3.4 nM
C#Cc1cccc(C[C@H](NC(=O)COC)[C@H](O)CN[C@H]2CC3(CCC3)Oc3ncc(CC(C)(C)C)cc32)c1 CHEMBL2181896 IC50 3.4 nM
COc1c(C)cc(C2(c3cccc(-c4cncnc4)c3)N=C(N)c3c(F)cccc32)cc1C#N CHEMBL2177918 IC50 3.4 nM
CO[C@H]1CC[C@]2(CC1)Cc1ccc(-c3cc(F)cc(C#N)c3)cc1C21N=C(C)C(N)=N1 CHEMBL3923132 IC50 3.4 nM
CC[C@@H]1C[C@@]2(Cc3ccc(C#N)cc3[C@]23N=C(N)N(CC(C)(C)F)C3=O)C[C@H](C)[C@H]1O CHEMBL3893067 IC50 3.4 nM
COc1ccc(C(=O)Nc2ccc(F)c([C@]3(C)CS(=O)(=O)C4(CC4)C(=N)N3)c2)nc1 CHEMBL3905648 Ki 3.4 nM
CN1C(=O)[C@]2(N=C1N)c1cc(-c3cccnc3F)ccc1CC21CCc2ccccc2CC1 CHEMBL4107165 IC50 3.4 nM
NC1=NC2(CCO1)c1cc(NC(=O)c3ccc(Cl)cn3)ccc1Oc1ncc(-c3ccnc(F)c3)cc12 CHEMBL3950676 IC50 3.4 nM
CO[C@H]1CC[C@]2(CC1)Cc1ccc(-c3cc(Cl)cc(C#N)c3)cc1[C@@]21COC(N)=N1 CHEMBL4072118 IC50 3.4 nM
C[C@]1(c2cc(NC(=O)c3ccc(F)cn3)ccc2F)N=C(N)O[C@H](CF)[C@@H]1F CHEMBL4226467 IC50 3.4 nM
C[C@@]1(c2nc(NC(=O)c3ccc(C#N)cn3)ccc2F)C[C@@H](C(F)(F)F)OC(N)=N1 CHEMBL4558124 IC50 3.4 nM
COC1CCC2(CC1)Cc1ccc(-c3cc(Cl)cc(C#N)c3)cc1C21N=C(N)N(C)O1 CHEMBL3652431 IC50 3.5 nM
C#CCOc1cnc(C(=O)Nc2ccc(F)c([C@@]3(C(F)F)N=C(N)O[C@@H]4C[C@@H]43)c2)cn1 CHEMBL3683851 IC50 3.5 nM
COC1CCC2(CC1)Cc1ccc(OCC3CC3)cc1C21N=C(N)N(C)C1=O CHEMBL3967730 IC50 3.5 nM
COC1CCC2(CC1)Cc1ccc(CCC3CC3)cc1C21N=C(N)N(CC2CCOC2)C1=O CHEMBL3898181 IC50 3.5 nM
[C-]#[N+]c1ccc2c(c1)[C@@]1(N=C(C)C(N)=N1)[C@@]1(C2)C[C@@H](C)[C@H](OC)[C@@H](C)C1 CHEMBL3977074 IC50 3.5 nM
CC#CCOc1ccc(C(=O)Nc2cc(F)c(F)c([C@]3(CF)C[C@@H](C(F)(F)F)OC(N)=N3)c2)nc1 CHEMBL3941417 IC50 3.5 nM
CC1(C)C(=N)N[C@@]2(c3cc(NC(=O)c4ccc(F)cn4)ccc3F)COC[C@H]2S1(=O)=O CHEMBL4109582 Ki 3.5 nM
NC1=N[C@@]2(c3cc(NC(=O)c4cnc(OCF)cn4)ccc3F)COCC[C@H]2CC1(F)F CHEMBL4637358 IC50 3.5 nM
CC#C[C@]1(c2cc(NC(=O)c3cnc(OCF)cn3)ccc2F)N=C(N)OCC12CC(F)(F)C2 CHEMBL4854629 Ki 3.5 nM
CC(C)[C@H](NC(=O)[C@H](C)C[C@H](O)[C@H](COCc1ccccc1)NC(=O)c1cc(C(=O)N[C@H](C)c2ccccc2)cc(N(C)S(C)(=O)=O)c1)C(=O)NCc1ccccc1 CHEMBL1076901 IC50 3.6 nM
CCc1ccc2c(c1)[C@@H](NC[C@@H](O)[C@H](Cc1ccccc1)NC(=O)c1cc(-c3ccccn3)c(=O)n(C3CCCC3)c1)CC1(CCC1)O2 CHEMBL2151148 IC50 3.6 nM
CC(=O)N[C@@H](Cc1ccccc1F)[C@H](O)CN[C@H]1CC2(CCC2)Oc2ncc(CC(C)(C)C)cc21 CHEMBL2151152 IC50 3.6 nM
COc1ccc(C[C@H](NC(C)=O)[C@H](O)CN[C@H]2CC3(CCC3)Oc3ncc(CC(C)(C)C)cc32)cc1F CHEMBL2151244 IC50 3.6 nM
CO[C@H]1CC[C@]2(CCc3ccc(-c4cc(Cl)cc(C#N)c4)cc3C23N=C(C)C(N)=N3)CC1 CHEMBL3672732 IC50 3.6 nM
COC1CCC2(CC1)Cc1ccc(C#CC3CC3)cc1C21N=C(N)c2ccc(C#N)cc21 CHEMBL3673223 IC50 3.6 nM
COc1cnc(C(=O)Nc2ccc(F)c([C@]3(C)CS(=O)(=O)C4(CCCC4)C(=N)N3)c2)cn1 CHEMBL3948118 Ki 3.6 nM
C[C@@]1(c2cc(NC(=O)c3ccc(C#N)cn3)ccc2F)C=C(CF)OC(N)=N1 CHEMBL4213486 IC50 3.6 nM
NC1=N[C@@]2(CO1)c1cc(NC(=O)c3ccc(Cl)cn3)ccc1Oc1cnc(C3CC3)cc12 CHEMBL4279064 IC50 3.6 nM
Cc1ccccc1-c1ccc2nc(N)c(CC(C)C(=O)NCC3CCCCC3)cc2c1 CHEMBL1821814 IC50 3.7 nM
CC(=O)N[C@@H](Cc1cccc(-c2nccs2)c1)[C@H](O)CN[C@H]1CC2(CCC2)Oc2ncc(CC(C)(C)C)cc21 CHEMBL2181908 IC50 3.7 nM
C#Cc1cc(C[C@H](NC(=O)COC)[C@H](O)CN[C@H]2CC3(CCC3)Oc3ncc(CC(C)(C)C)cc32)ccc1F CHEMBL2181905 IC50 3.7 nM
CO[C@H]1CC[C@]2(CC1)Cc1ccc(OCC3CC3)cc1[C@@]21N=C(C)C(N)=N1 CHEMBL3937398 IC50 3.7 nM
CO[C@H]1CC[C@]2(CC1)Cc1ccc(OCCC3CC3)cc1C21N=C(C)C(N)=N1 CHEMBL3939963 IC50 3.7 nM
COC1CCC2(CC1)Cc1ccc(C#CC(F)(F)F)cc1C21N=C(N)N(C)O1 CHEMBL3928953 IC50 3.7 nM
CN1C(=N)N[C@](C)(c2sc(-c3cncc(-c4nnco4)c3)cc2F)CS1(=O)=O CHEMBL3924686 Ki 3.7 nM
C[C@@]1(c2cc(NC(=O)c3ccc(C#N)cn3)ccc2F)CS(=O)(=O)C2(CNC2)C(=N)N1 CHEMBL3897125 Ki 3.7 nM
C[C@@]1(c2cc(NC(=O)c3ccc(C#N)cn3)ccc2F)CCOC(N)=N1 CHEMBL2347203 IC50 3.7 nM
C[C@]1(c2cc(NC(=O)c3cnc(C(F)F)cn3)ccc2F)N=C(N)O[C@H](CF)[C@@H]1F CHEMBL4226730 IC50 3.7 nM
C[C@@]1(c2cc(NC(=O)c3ccc(C#N)cn3)ccc2F)Cn2c(C#N)cnc2C(N)=N1 CHEMBL2152899 IC50 3.7 nM
C[C@@]1(c2cc(NC(=O)c3cnc(C(F)F)cn3)ccc2F)Cn2nc(C#N)cc2C(N)=N1 CHEMBL5077699 IC50 3.7 nM
NC1=N[C@@]2(CO1)c1cc(-c3cccnc3F)ccc1Oc1cnc(-c3ccccn3)cc12 CHEMBL3394053 IC50 3.8 nM
C[C@H]1C[C@H]2CSC(N)=N[C@@]2(c2nc(NC(=O)c3ccc(Cl)cn3)cs2)CO1 CHEMBL3967984 IC50 3.8 nM
C[C@@H]1O[C@@H](OC[C@H]2O[C@@H](Oc3c(-c4ccc(O)c(O)c4)oc4cc(O)cc(O)c4c3=O)[C@H](O)[C@@H](O)[C@@H]2O)[C@H](O)[C@H](O)[C@H]1O CHEMBL226335 IC50 3.8 nM
CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)CNC(=O)c1nn[nH]n1)C(C)C)C(=O)N[C@@H](Cc1ccccc1)[C@@H](O)C(=O)Nc1cc(C(=O)O)cc(C(=O)O)c1 CHEMBL183546 IC50 3.9 nM
CO[C@H]1CC[C@]2(CC1)Cc1ccc(Oc3ccccc3)cc1[C@]21N=C(N)N(C)C1=O CHEMBL3971363 IC50 3.9 nM
CO[C@H]1CC[C@]2(CC1)Cc1ccc(-c3cc(F)ccc3F)cc1[C@@]21N=C(C)C(N)=N1 CHEMBL3903281 IC50 3.9 nM
CC#CCOc1cnc(C(=O)Nc2ccc(Cl)c([C@]3(C(F)F)N=C(N)O[C@H]4C[C@H]43)c2)cn1 CHEMBL3688641 IC50 3.9 nM
CN1C(=N)N[C@](C)(c2sc(-c3cccc(-c4ncon4)c3)cc2F)CS1(=O)=O CHEMBL3908329 Ki 3.9 nM
C[C@H]1C[C@H]2CSC(N)=N[C@@]2(c2nc(NC(=O)c3ccc(C#N)cn3)cs2)CO1 CHEMBL4211913 IC50 3.9 nM
Cn1cc2n(c1=O)C[C@@](C)(c1cc(NC(=O)c3ccc(C#N)cn3)ccc1F)N=C2N CHEMBL4473230 IC50 3.9 nM
C[C@@]1(S(C)(=O)=O)CC[C@@](CF)(c2cc(NC(=O)c3cc4c(cn3)OC(F)(F)O4)ccc2F)N=C1N CHEMBL5090362 IC50 3.9 nM
CCn1cc(C2(c3cccc(-c4cncc(F)c4)c3)N=C(N)c3c(F)cccc32)cc(C)c1=O CHEMBL2177301 IC50 3.98 nM
C[C@@]1(c2cc(NC(=O)c3ccc(C#N)cn3)ccc2F)Cn2cncc2C(N)=N1 CHEMBL4557890 pIC50 3.981 nM
CCC[C@H](NC[C@H](Cc1ccccc1)NC(=O)c1cc(C(=O)N[C@H](C)c2ccc(F)cc2)cc(N(C)S(C)(=O)=O)c1)C(=O)NCC(C)C CHEMBL211563 IC50 4.0 nM
CCCC[C@H](NC[C@@H]1Cc2cccc(c2)CCCCc2cc(cc(N(CCC)S(C)(=O)=O)c2)C(=O)N1)C(=O)NCC(C)C CHEMBL385374 IC50 4.0 nM
CCCCS(=O)(=O)C[C@@H](NC(=O)OCC(F)(F)F)C(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)CNCc1cccc(CC)c1 CHEMBL231865 IC50 4.0 nM
CCCCS(=O)(=O)C[C@@H](NC(=O)c1ncc[nH]1)C(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)CNCc1cccc(CC)c1 CHEMBL391144 IC50 4.0 nM
CCCCS(=O)(=O)C[C@@H](NC(=O)c1cc(C)[nH]n1)C(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)CNCc1cccc(CC)c1 CHEMBL409947 IC50 4.0 nM
CCCC(CCC)S(=O)(=O)C[C@@H](NC(=O)OCc1cccnc1)C(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)CNCc1cccc(CC)c1 CHEMBL414776 IC50 4.0 nM
CCCC(CCC)S(=O)(=O)C[C@@H](NC(=O)c1ccc(C)cc1)C(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)CNCc1cccc(CC)c1 CHEMBL412852 IC50 4.0 nM
CCCCS(=O)(=O)C[C@@H](NC(=O)SC1CCOC1)C(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)CNCc1cccc(CC)c1 CHEMBL409948 EC50 4.0 nM
CCCCS(=O)(=O)C[C@@H](NC(=O)C1CC1)C(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)CNCc1cccc(CC)c1 CHEMBL231669 EC50 4.0 nM
CCCCS(=O)(=O)C[C@@H](NC(=O)COC)C(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)CNCc1cccc(CC)c1 CHEMBL398775 EC50 4.0 nM
CN(C)S(=O)(=O)N(C)c1cc2cc(c1)C(=O)N[C@@H](c1ccccc1)CCc1cccc(c1)C[C@@](C)(N)C(=O)OC2 CHEMBL427884 IC50 4.0 nM
CCNc1cc(C(=O)N[C@@H](Cc2ccccc2)[C@H](O)CNCc2cccc(OC)c2)c(F)c(N2CCCCS2(=O)=O)c1 CHEMBL264322 IC50 4.0 nM
CCCN(CCC)C(=O)c1cc(C)cc(C(=O)N[C@@H](Cc2cc(F)cc(F)c2)[C@H](O)[C@H]2C[C@@H](OCCOC)CCN2)c1 CHEMBL257645 IC50 4.0 nM
COC[C@H]1CCCN1C(=O)c1cc(OC)cc(C(=O)N[C@@H](Cc2cc(F)cc(F)c2)[C@H](O)[C@@H]2NCCN(Cc3ccccc3)C2=O)c1 CHEMBL453413 IC50 4.0 nM
CCCN(CCC)C(=O)c1cc(C(C)=O)cc(C(=O)N[C@@H](Cc2cc(F)cc(F)c2)[C@H](O)CNCc2cccc(OC)c2)c1 CHEMBL538636 IC50 4.0 nM
C[C@@H](NC(=O)c1cc(-c2ccc(C(C)(N)Cc3ccccc3)o2)cc(N(C)S(C)(=O)=O)c1)c1ccc(F)cc1 CHEMBL1092146 IC50 4.0 nM
COCCN(C[C@H]1C[C@@H]1C)c1cc(-c2nnc([C@](C)(N)Cc3ccc(Cl)cc3)o2)c(Cl)c(N(C)S(C)(=O)=O)n1 CHEMBL1087750 IP 4.0 nM
CS(=O)(=O)N(c1ccccc1)c1cc(C(=O)N[C@@H](Cc2ccccc2)[C@H](O)CNCc2cccc(C(F)(F)F)c2)cc(C2CCCC2)c1 CHEMBL1210434 IC50 4.0 nM
CC(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)CNC1(c2cccc(-n3cccn3)c2)CCCCC1 CHEMBL572081 ED50 4.0 nM
CCC(C)[C@@]1(NC(C)=O)CCN([C@@H](CCc2ccccc2)C(=O)N[C@@H](Cc2cc(F)cc(F)c2)[C@H](O)C2Cc3cccc(OC)c3CN2)C1=O CHEMBL1917907 IC50 4.0 nM
CC(=O)N[C@@H](Cc1ccc(F)cc1)[C@H](O)CN[C@H]1C[C@]2(C[C@H](C)C2)Oc2ncc(CC(C)(C)C)cc21 CHEMBL2031141 IC50 4.0 nM
CC(C)(C)Cc1cnc2c(c1)[C@@H](NC[C@@H](O)[C@H](Cc1ccc(F)cc1)NC(=O)CF)C[C@]1(C[C@H](O)C1)O2 CHEMBL2031150 IC50 4.0 nM
COCCOC[C@@H](Oc1cc(C[C@@H]2CS(=O)(=O)C[C@H](NCc3cccc(C(C)(C)C)c3)[C@H]2O)cc(F)c1N)C(F)(F)F CHEMBL2048054 IC50 4.0 nM
CC(=O)N[C@@H](Cc1ccc(F)c(C)c1)[C@H](O)CN[C@H]1CC2(CCC2)Oc2ncc(CC(C)(C)C)cc21 CHEMBL2151238 IC50 4.0 nM
CC#Cc1cncc(-c2cccc([C@@]3(c4cc(C(F)F)c(=O)n(CC)c4)N=C(N)c4c(F)cccc43)c2)c1 CHEMBL2152905 IC50 4.0 nM
CN1C(=N)N[C@@]2(c3cc(-c4cccc(C#N)c4)cs3)CN(c3ncc(F)cn3)C[C@H]2C1=O CHEMBL2178718 Ki 4.0 nM
CC(=O)N[C@@H](Cc1ccccc1)[C@H](O)CN[C@H]1CC2(CCC2)Oc2ncc(CC(C)C)cc21 CHEMBL2177107 IC50 4.0 nM
COc1ccc(-c2nsc(C)c2C(=O)/N=C(\N)NCc2cc(Cl)c(NC(=O)CN3CCC3)c(Cl)c2)cc1 CHEMBL2178164 Ki 4.0 nM
C[C@]1(c2cc(NC(=O)c3ccc(Cl)cn3)ccc2F)N=C(N)SCC1(F)F CHEMBL2347212 IC50 4.0 nM
C[C@@]1(c2cc(NC(=O)c3ncc(Cl)cc3Cl)ccc2F)COCC(N)=N1 CHEMBL2403770 IC50 4.0 nM
[2H]C([2H])(N[C@H]1C[S@+]([O-])C[C@@H](Cc2cc(F)c(N)c(O[C@H](COC)C(F)(F)F)c2)[C@@H]1O)c1cccc(C(C)(C)C)c1 CHEMBL2425617 IC50 4.0 nM
COC[C@@H](Oc1cc(C[C@@H]2C[S@@+]([O-])C[C@H](NCc3cccc(C(C)(C)C)c3)[C@H]2O)cc(F)c1N)C(F)(F)F CHEMBL2425612 IC50 4.0 nM
COC1CCC2(CC1)Cc1ccc(-c3cccc(C#N)c3)cc1C21N=C(N)N(C)C1=O CHEMBL3260841 IC50 4.0 nM
NC1=N[C@]2(CO1)c1cc(C3=CCOCC3)ccc1Oc1ccc(-c3cncnc3)cc12 CHEMBL3354693 IC50 4.0 nM
COC(C)(C)COc1ccc2c(c1)[C@]1(COC(N)=N1)c1cc(-c3cncnc3)ccc1O2 CHEMBL3354698 IC50 4.0 nM
CC(C)(C)COc1ccc2c(c1)[C@]1(COC(N)=N1)c1cc(-c3cccnc3)ccc1O2 CHEMBL3354704 IC50 4.0 nM
CC(C)(C)COc1ccc2c(c1)[C@]1(COC(N)=N1)c1cc(-c3cncc(F)c3)ccc1O2 CHEMBL3354707 IC50 4.0 nM
COc1cncc(-c2ccc3c(c2)[C@@]2(COC(N)=N2)c2cc(OCC(C)(C)C)ccc2O3)c1 CHEMBL3354708 IC50 4.0 nM
CC1(COc2cc3c(cc2F)Oc2ccc(-c4cccnc4)cc2[C@@]32COC(N)=N2)COC1 CHEMBL3354712 IC50 4.0 nM
CC1(C)CN(c2cc3c(cn2)Oc2ccc(-c4cccnc4F)cc2[C@@]32COC(N)=N2)CCO1 CHEMBL3394047 IC50 4.0 nM
Cn1cc([C@H]2C[C@H]3CSC(N)=N[C@@]3(c3ccc(F)cc3F)CO2)cn1 CHEMBL3422238 IC50 4.0 nM
Cc1coc([C@H]2C[C@H]3CSC(N)=N[C@@]3(c3ccc(F)cc3F)CO2)n1 CHEMBL3422236 IC50 4.0 nM
COc1ccc(C(=O)Nc2ccc(F)c([C@@]3(C)N=C(N)OC[C@@H]3F)c2)nc1 CHEMBL3680865 IC50 4.0 nM
C[C@]1(c2cc(NC(=O)c3ccc(C#CC4CC4)cn3)ccc2F)N=C(N)OC[C@@H]1F CHEMBL3680866 IC50 4.0 nM
C[C@]1(c2cc(NC(=O)c3ncc(C(F)(F)F)cc3F)ccc2F)N=C(N)OC[C@@H]1F CHEMBL3680864 IC50 4.0 nM
COC1CCC2(CC1)Cc1ccc(-c3cccc(C#N)c3)cc1C21N=C(N)N(C)C1=O CHEMBL3652433 IC50 4.0 nM
Cc1cc(C#N)cnc1C(=O)Nc1ccc(F)c([C@]2(C)CO[C@@](C)(C(F)(F)F)C(N)=N2)n1 CHEMBL3261069 IC50 4.0 nM
CC#CCOc1cnc(C(=O)Nc2ccc(F)c([C@]3(C(F)F)COCC(N)=N3)c2)c(C)n1 CHEMBL3653505 IC50 4.0 nM
CO[C@H]1[C@H](C)C[C@@]2(Cc3ccc(C#N)cc3[C@]23N=C(N)N(CC2(C)COC2)C3=O)C[C@@H]1C CHEMBL4109666 IC50 4.0 nM
COC1CCC2(CC1)Cc1ccc(-c3cccc(C#N)c3)cc1C21C=C(N)N(C)C1=O CHEMBL3978600 IC50 4.0 nM
COC1CCC2(CC1)Cc1ccc(C#CCC(C)C)cc1C21N=C(N)N(C)C1=O CHEMBL3925553 IC50 4.0 nM
CCCNc1ccc2c(c1)C1(N=C(N)N(C)C1=O)C1(CCC(OC)CC1)C2 CHEMBL3918820 IC50 4.0 nM
CO[C@H]1[C@H](C)CC2(Cc3ccc(Br)cc3[C@@]23N=C(C)C(N)=N3)C[C@@H]1C CHEMBL3900965 IC50 4.0 nM
C[C@H]1C[C@H]2CSC(N)=NC2(c2nc(NC(=O)c3nn(C(F)F)cc3Cl)cs2)CO1 CHEMBL3981156 IC50 4.0 nM
COc1cnc(C(=O)Nc2ccc(F)c([C@]34COC[C@H]3S(=O)(=O)C(C)(C)C(=N)N4)c2)c(C)c1 CHEMBL4113267 Ki 4.0 nM
COc1cnc(C(=O)Nc2ccc(F)c([C@]34COC(CF)[C@H]3S(=O)(=O)C(C)(C)C(=N)N4)c2)cn1 CHEMBL4107633 Ki 4.0 nM
CCNS1(O)C[C@@](C)(c2cc(NC(=O)c3ccc(Cl)cn3)ccc2F)NC(=N)C1(C)C CHEMBL3902472 Ki 4.0 nM
CCNS1(O)C[C@@](C)(c2cc(NC(=O)c3ccc(C#N)cn3)ccc2F)NC(=N)C1(C)C CHEMBL3985262 Ki 4.0 nM
COC[C@@H](C)NCc1cc([C@]2(C)CCSC(N)=N2)c(F)cc1F CHEMBL4084653 IC50 4.0 nM
C[C@@]1(c2cc(CNC34CC(C3)C4)c(F)cc2F)CCSC(N)=N1 CHEMBL4102593 IC50 4.0 nM
CN1C(=N)N[C@@]2(c3cc(NC(=O)c4ccc(OC(F)F)cn4)ccc3F)CCC[C@H]2S1(=O)=O CHEMBL4130055 Ki 4.0 nM
CN1C(=N)N[C@@]2(c3cc(NC(=O)c4ccc(C#N)cn4)ccc3F)CCC[C@H]2S1(=O)=O CHEMBL4129113 Ki 4.0 nM
CN1C(=N)N[C@@]2(c3cc(NC(=O)c4ncc(Cl)cc4F)ccc3F)CCC[C@H]2S1(=O)=O CHEMBL4129654 Ki 4.0 nM
CN1C(=N)N[C@@]2(c3cc(NC(=O)c4nccc5cc(Br)cnc45)ccc3F)CCC[C@H]2S1(=O)=O CHEMBL4128375 Ki 4.0 nM
NC1=N[C@](CF)(c2cccc(NC(=O)c3ccc(Br)cn3)c2)COC1 CHEMBL3653370 IC50 4.0 nM
Cc1cc(C#N)cnc1C(=O)Nc1ccc(F)c([C@]2(C(F)F)COC3(CC3)C(N)=N2)c1 CHEMBL4128406 IC50 4.0 nM
CO[C@]1(C)OC[C@@](C)(c2cc(NC(=O)c3ncc(C#N)cc3C)ccc2F)N=C1N CHEMBL4126351 IC50 4.0 nM
CN1C(=N)N[C@@]2(c3cc(-c4ccc(F)c(C#N)c4)cs3)CN(c3ncc(F)cn3)C[C@H]2C1=O CHEMBL4286732 Ki 4.0 nM
C[C@]1(c2cc(NC(=O)c3cnc(OCF)cn3)ccc2F)N=C(N)SCC12CCC(F)(F)CC2 CHEMBL4443968 Ki 4.0 nM
COc1cnc(C(=O)Nc2ccc(F)c([C@]3(C)CS(=O)(=O)[C@](C)(CF)C(=N)N3)c2)cn1 CHEMBL5195634 Ki 4.0 nM
CN(C)S(=O)(=O)[C@]1(C)CC[C@@](CF)(c2cc(-c3ccc(F)cn3)ccc2F)N=C1N CHEMBL5180053 IC50 4.0 nM
COc1cnc(-c2ccc(F)c([C@]3(C)CC[C@@](C)(S(C)(=O)=O)C(N)=N3)c2)cn1 CHEMBL5186218 IC50 4.0 nM
COC1CCC2(CC1)Cc1ccc(C#CC3CC3)cc1C21N=C(N)c2cc(C#N)ccc21 CHEMBL3673237 IC50 4.09 nM
COCC(=O)N[C@@H](Cc1cccc(-c2nccs2)c1)[C@H](O)CN[C@H]1CC2(CCC2)Oc2ncc(CC(C)(C)C)cc21 CHEMBL2181892 IC50 4.1 nM
Cc1ccc(-c2cc(F)c3c(c2)[C@]2(N=C(N)N(C)C2=O)c2cc(-c4cccc(Cl)c4)ccc2O3)cc1 CHEMBL3695732 IC50 4.1 nM
C[C@@]1(c2cc(NC(=O)c3ncc(Cl)cc3Cl)ccc2F)CS(=O)(=O)C2(CCOCC2)C(=N)N1 CHEMBL3913650 Ki 4.1 nM
CN1C(=O)C2(NC1N)c1cc(OCC3CC3)ccc1OC21CCc2ccccc2CC1 CHEMBL3955763 IC50 4.1 nM
CC1(C)Oc2ccc(NC(=O)c3ncc(Br)cn3)cc2C2(COC(N)=N2)C12COC2 CHEMBL3650821 IC50 4.1 nM
Cc1cc(C#N)cnc1C(=O)Nc1ccc(F)c([C@]2(C)CS(=O)(=O)C3(CNC3)C(=N)N2)c1 CHEMBL3915974 Ki 4.1 nM
CC1(c2cc(NC(=O)c3ccc(C#N)cn3)ccc2F)Cc2ncccc2C(N)=N1 CHEMBL4847576 IC50 4.1 nM
CCC(C)[C@@]1(NC(C)=O)CCN([C@@H](CCc2ccccc2)C(=O)N[C@@H](Cc2cc(F)cc(F)c2)[C@H](O)[C@H]2Cc3cccc(OC)c3CN2)C1=O CHEMBL1915989 IC50 4.2 nM
CO[C@H]1CC[C@]2(CC1)Cc1ccc(C#CC3CCC3)cc1[C@@]21N=C(C)C(N)=N1 CHEMBL3891777 IC50 4.2 nM
COc1cnc(C(=O)Nc2ccc(F)c([C@]3(C)CS(=O)(=O)C4(CC4)C(=N)N3)c2)cn1 CHEMBL3983432 Ki 4.2 nM
COC1CCC2(CC1)Cc1ccc(-c3cc(Cl)cc(Cl)c3)cc1[C@]21N=C(N)N(C)C1=O CHEMBL4110527 IC50 4.2 nM
CCOc1cnc(C(=O)Nc2cc(F)c(F)c([C@@]3(C)N=C(N)S[C@@]4(COC)C[C@H]43)c2)cn1 CHEMBL4593414 IC50 4.2 nM
C[C@@]1(c2cc(NC(=O)c3ccc(F)cn3)ccc2F)C=CSC(N)=N1 CHEMBL3670327 IC50 4.2 nM
COC1CCC2(CC1)Cc1ccc(C#CC3CC3)cc1C21NC(N)N(Cc2nnc(C)o2)C1=O CHEMBL3956596 IC50 4.3 nM
Cc1cc(C#N)cnc1C(=O)Nc1ccc(F)c([C@@]2(C)N=C(N)[C@@](C)(F)CC2(F)F)c1 CHEMBL3927068 Ki 4.3 nM
Cc1ccn2c(NC3CCCCC3)c(-c3ccc(OCCCN4C(=O)c5ccccc5C4=O)cc3)nc2c1 CHEMBL4215348 Ki 4.38 nM
COc1nc(N2C[C@H]3C(=O)N(C)C(N)=N[C@@]3(c3ccc(F)cc3)C2)nc(OC)c1F CHEMBL3640273 Ki 4.4 nM
CC1=C[C@@](C)(c2cc(NC(=O)c3ccc(C#N)cn3)ccc2F)N=C(N)O1 CHEMBL3658616 IC50 4.4 nM
COc1cnc(C(=O)Nc2ccc(F)c([C@]3(C)C=CSC(N)=N3)c2)cn1 CHEMBL3891839 IC50 4.4 nM
Cc1cccc(C(=O)N2Cc3ccc(N4C(=O)c5ccccc5C4=O)cc3CC2=O)c1 CHEMBL5273978 IC50 4.45 nM
O=C1c2ccccc2C(=O)N1CCCOc1ccc(-c2nc3ccc(Br)cn3c2NC2CCCCC2)cc1 CHEMBL4205452 Ki 4.46 nM
COc1cc(C[C@H](NC(C)=O)[C@H](O)CN[C@H]2CC3(CCC3)Oc3ncc(CC(C)(C)C)cc32)ccc1F CHEMBL2151242 IC50 4.5 nM
CC(C)(C)C#Cc1cnc2c(c1)[C@]1(COC(N)=N1)c1cc(-c3cccnc3F)ccc1O2 CHEMBL3359760 IC50 4.5 nM
COc1nc(N2C[C@H]3C(=O)N(C)C(N)=N[C@@]3(c3ccc(F)cc3Cl)C2)nc(C)c1F CHEMBL3640266 Ki 4.5 nM
CO[C@H]1CC[C@]2(CC1)Cc1ccc(C#CC3CC3)cc1C21N=C(N)N(CC(=O)OC(C)C)C1=O CHEMBL3916361 IC50 4.5 nM
COC1CCC2(CC1)Cc1ccc(C#CC3CC3)cc1C21N=C(N)N(C)O1 CHEMBL3652432 IC50 4.5 nM
COC1CCC2(CC1)Cc1ccc(-c3cccc(Cl)c3)cc1C21N=C(N)N(C)O1 CHEMBL3652434 IC50 4.5 nM
CO[C@H]1CC[C@]2(CC1)Cc1ccc(OCC3CCC3)cc1[C@@]21N=C(C)C(N)=N1 CHEMBL3927449 IC50 4.5 nM
C[C@@H]1C[C@@]2(Cc3ccc(C#N)cc3[C@]23N=C(N)N(CC2CC(F)(F)C2)C3=O)C[C@H](C)[C@H]1O CHEMBL4110323 IC50 4.5 nM
COC1CCC2(CC1)Cc1ccc(C#CC3CC3)cc1C21C=C(N)N(C)O1 CHEMBL3949520 IC50 4.5 nM
COC1CCC2(CC1)Cc1ccc(-c3cncc(F)c3)cc1C21N=C(N)N(Cc2ccccc2)C1=O CHEMBL3916549 IC50 4.5 nM
C[C@@]1(c2nc(NC(=O)c3ncc(C#N)cc3Cl)ccc2F)C[C@@H](C(F)(F)F)OC(N)=N1 CHEMBL3945149 IC50 4.5 nM
CO[C@H]1CSC(N)=N[C@]1(C)c1cc(NC(=O)c2cnc(OCF)cn2)ccc1F CHEMBL4451133 IC50 4.5 nM
O=C1c2ccccc2C(=O)N1CCCOc1ccc(-c2nc3ccc(Cl)cn3c2NC2CCCCC2)cc1 CHEMBL4213285 Ki 4.59 nM
CN(c1cc2cc(c1)C(=O)N[C@H]([C@H](O)CNCc1cccc(C(C)(C)C)c1)COC/C=C/CCNC2=O)S(C)(=O)=O CHEMBL2047034 IC50 4.6 nM
CO[C@H]1CC[C@]2(CC1)Cc1ccc(C#CC3CC3)cc1C21N=C(N)c2ccc(C#N)cc21 CHEMBL3911056 IC50 4.6 nM
CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)CNC(=O)C(=O)O)C(C)C)C(=O)N[C@@H](Cc1ccccc1)[C@@H](O)C(=O)Nc1cc(C(=O)O)cc(C(=O)O)c1 CHEMBL181826 IC50 4.7 nM
CCCO[C@H]1CN[C@@H]([C@@H](O)[C@H](Cc2cc(F)cc(F)c2)NC(=O)[C@H](CCc2ccccc2)N2CC[C@H]([C@H](O)CCC)C2=O)C1 CHEMBL1915996 IC50 4.7 nM
C=CCCCC(=O)N[C@@H](Cc1cccc(CC=C)c1)[C@H](O)CN[C@H]1CC2(CCC2)Oc2ncc(CC(C)(C)C)cc21 CHEMBL2407339 IC50 4.7 nM
COc1nc(N2C[C@H]3C(=O)N(C)C(=N)N[C@@]3(c3ccc(F)cc3F)C2)nc(C)c1F CHEMBL3640290 Ki 4.7 nM
CO[C@H]1CC[C@]2(CC1)Cc1ccc(C#CC(C)C)cc1[C@@]21N=C(C)C(N)=N1 CHEMBL3893021 IC50 4.7 nM
CO[C@H]1CC[C@]2(CC1)Cc1ccc(OCCC(F)(F)F)cc1[C@@]21N=C(C)C(N)=N1 CHEMBL3898248 IC50 4.7 nM
[C-]#[N+]c1cccc(-c2ccc3c(c2)C2(N=C(N)N(C)O2)C2(CCC(OC(F)F)CC2)C3)c1 CHEMBL3913489 IC50 4.7 nM
COC1CCC2(CC1)Cc1ccc(C#CC3CC3)cc1C21NC(N)N(CCC(N)=O)C1=O CHEMBL3903804 IC50 4.7 nM
CN1C(=N)N[C@](C)(c2sc(-c3cccc(-c4ncco4)c3)cc2Cl)CS1(=O)=O CHEMBL3891425 Ki 4.7 nM
O=C(/C=C/c1ccc(F)cc1)c1cc(I)c(Br)cc1O CHEMBL5291052 IC50 4.703 nM
CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)CNC(=O)c1nn[nH]n1)C(C)C)C(=O)N[C@@H](Cc1ccccc1)[C@@H](O)C(=O)Nc1cccc(-c2nn[nH]n2)c1 CHEMBL381826 IC50 4.8 nM
COc1nc(N2C[C@H]3C(=O)N(C)C(N)=N[C@@]3(c3ccc(F)cc3)C2)nc(C2CC2)c1F CHEMBL3640267 Ki 4.8 nM
COC1CCC2(CC1)Cc1ccc(-c3cc(Cl)cc(Cl)c3)cc1C21N=C(N)N(C)O1 CHEMBL3652435 IC50 4.8 nM
COC1CCC2(CC1)Cc1ccc(-c3cncc(C(F)(F)F)c3)cc1[C@]21N=C(N)N(C(C)C)C1=O CHEMBL4113458 IC50 4.8 nM
Cc1cc(C#N)cnc1C(=O)Nc1ccc(F)c([C@]2(C)C[C@@H](C(F)(F)F)OC(N)=N2)n1 CHEMBL3926112 IC50 4.8 nM
[2H]C1([2H])OC(N)=N[C@]12c1cc(-c3cc(Cl)cc(C#N)c3)ccc1C[C@]21CC[C@@H](OC)CC1 CHEMBL4062699 IC50 4.8 nM
C[C@H]1C[C@H]2CSC(N)=N[C@@]2(c2nc(NC(=O)c3ccc(C(F)(F)F)cn3)cs2)CO1 CHEMBL3917530 IC50 4.8 nM
CN1C(=N)N[C@](C)(c2c(F)ccc(NC(=O)c3ccc(F)cn3)c2F)CS1(=O)=O CHEMBL3702860 Ki 4.88 nM
CC#Cc1cc(-c2ccc3c(c2)C2(N=C(C)C(N)=N2)[C@]2(CC[C@H](OC)CC2)C3)ccn1 CHEMBL3939422 IC50 4.9 nM
COC1CCC2(CC1)Cc1ccc(C#CC(F)(F)F)cc1C21N=C(N)N(C)C1=O CHEMBL3980027 IC50 4.9 nM
CC#Cc1cncc(-c2ccc3c(c2)C2(COC(N)=N2)C2(COC2)C(Cc2ccccc2)O3)c1 CHEMBL3650832 IC50 4.9 nM
C[C@@]1(c2cc(NC(=O)c3ccc(Cl)cn3)ccc2F)C[C@@H](C(F)(F)F)OC(N)=N1 CHEMBL3929456 IC50 4.9 nM
CN1CC2(C1)C(=N)N[C@](C)(c1cc(NC(=O)c3ccc(OCF)cn3)ccc1F)CS2(=O)=O CHEMBL3945094 Ki 4.9 nM
COc1cnc(C(=O)Nc2ccc(F)c([C@@]3(C)N=C(N)CO[C@H]3C(F)F)c2)cn1 CHEMBL4162197 IC50 4.9 nM
CCCN(CCC)C(=O)c1cc(C)cc(C(=O)N[C@@H](Cc2cc(F)cc(F)c2)[C@H](O)CNCc2cccc(I)c2)c1 CHEMBL373533 IC50 5.0 nM
CCCN(CCC)C(=O)c1cc(C(N)=O)cc(C(=O)N[C@@H](Cc2cc(F)cc(F)c2)[C@H](O)CNCc2cccc(CC)c2)c1 CHEMBL397714 IC50 5.0 nM
CCCCS(=O)(=O)C[C@@H](NC(=O)c1cnccc1O)C(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)CNCc1cccc(CC)c1 CHEMBL266531 IC50 5.0 nM
CCCC(CCC)S(=O)(=O)C[C@@H](NC(=O)c1cccc(Cl)c1)C(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)CNCc1cccc(CC)c1 CHEMBL266565 IC50 5.0 nM
CCCCS(=O)(=O)CC(NC(=O)OCCC#N)C(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)CNCc1cccc(CC)c1 CHEMBL231864 EC50 5.0 nM
CCNc1cc(C(=O)N[C@@H](Cc2cc(F)cc(F)c2)[C@H](O)CNCc2cccc(OC)c2)cc(N2CCCCS2(=O)=O)c1 CHEMBL409766 IC50 5.0 nM
CCNc1cc(C(=O)N[C@@H](Cc2ccccc2)[C@H](O)CNCc2cccc(OC(F)(F)F)c2)cc(N2CCCCS2(=O)=O)c1 CHEMBL409753 IC50 5.0 nM
CCOc1cc(C(=O)N[C@@H](Cc2ccccc2)[C@H](O)CNCc2cccc(OC(F)(F)F)c2)cc(N2CCCCS2(=O)=O)c1 CHEMBL409752 IC50 5.0 nM
CCCc1cc(C(=O)N[C@@H](Cc2ccccc2)[C@H](O)CNCc2cccc(C(F)(F)F)c2)cc(N2CCCCS2(=O)=O)c1 CHEMBL264321 IC50 5.0 nM
CCCN(CCC)C(=O)c1cc(C)cc(C(=O)N[C@@H](Cc2cc(F)cc(F)c2)[C@H](O)[C@H]2C[C@@H](OCc3ccccc3)CN2)c1 CHEMBL270359 IC50 5.0 nM
CCCN(CCC)C(=O)c1cc(C)cc(C(=O)N[C@@H](Cc2cc(F)cc(F)c2)[C@H](O)[C@@H]2NCCN(Cc3ccccc3OC)C2=O)c1 CHEMBL445721 IC50 5.0 nM
CCCCN1CC(C(=O)N[C@@H](Cc2cc(F)cc(F)c2)[C@H](O)[C@@H]2NCCN(Cc3ccccc3)C2=O)CC1=O CHEMBL491071 IC50 5.0 nM
CCCN(CCC)C(=O)c1cc(C)cc(C(=O)N[C@@H](Cc2cc(F)cc(F)c2)[C@H](O)[C@@H]2NCN(Cc3ccccc3)C2=O)c1 CHEMBL507651 IC50 5.0 nM
CCc1cn2c3c(cc(C(=O)N[C@@H](Cc4ccccc4)[C@H](O)CNC4CCCCC4)cc13)N(C)S(=O)(=O)CC2 CHEMBL504197 IC50 5.0 nM
CCc1cn2c3c(cc(C(=O)N[C@@H](Cc4ccccc4)[C@H](O)CNC4CCOCC4)cc13)N(CC)S(=O)(=O)CC2 CHEMBL562555 IC50 5.0 nM
CCc1cn2c3c(cc(C(=O)N[C@@H](Cc4ccccc4)[C@H](O)CNC(C)(C)CCCC(C)C)cc13)N(C)S(=O)(=O)CC2 CHEMBL541757 IC50 5.0 nM
CCn1cc2c3c(cc(C(=O)N[C@@H](Cc4ccccc4)[C@H](O)CNc4ccccc4)cc31)N(C)S(=O)(=O)CC2 CHEMBL560151 IC50 5.0 nM
CCn1cc2c3c(cc(C(=O)N[C@@H](Cc4ccccc4)[C@H](O)CNC4CCOCC4)cc31)N(C)S(=O)(=O)CC2 CHEMBL559355 IC50 5.0 nM
C[C@@H](NC(=O)c1cc(-c2ncc([C@](C)(N)Cc3ccccc3)o2)cc(N(C)S(C)(=O)=O)c1)c1ccc(F)cc1 CHEMBL1096683 IC50 5.0 nM
CCCN(CCC)C(=O)c1cc(C)cc(C(=O)N[C@@H](Cc2cc(F)cc(F)c2)[C@H](O)[C@H]2CN(S(=O)(=O)c3ccccc3C)CCN2)c1 CHEMBL1097320 Ki 5.0 nM
NC1=Nc2ccc3cc2CN1[C@H](C1CCCCC1)CCC(=O)N(C1CCCCC1)CCc1cccc(c1)O3 CHEMBL1098733 Ki 5.0 nM
NC1=Nc2cnc3cc2CN1[C@H](C1CCCCC1)CCC(=O)N(C1CCCCC1)CCc1cccc(c1)O3 CHEMBL1095431 Ki 5.0 nM
CCNc1cc(C(=O)N[C@@H](Cc2ccccc2)[C@H](O)CNc2cccc(C(F)(F)F)c2)cc(N2CCCCS2(=O)=O)c1 CHEMBL1165545 IC50 5.0 nM
CC(C)c1cc(C(=O)N[C@@H](Cc2ccccc2)[C@H](O)CNCc2cccc(C(F)(F)F)c2)cc(N(c2ccccc2)S(C)(=O)=O)c1 CHEMBL1210361 IC50 5.0 nM
CCC(C)[C@@]1(NC(C)=O)CCN([C@@H](CCc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)[C@H](O)CNCc2cccc(OC)c2)C1=O CHEMBL1917902 IC50 5.0 nM
CCCS(=O)(=O)[C@H]1CN[C@@H]([C@@H](O)[C@H](Cc2cc(F)cc(F)c2)NC(=O)[C@H](CCc2ccccc2)N2CC[C@](NC(C)=O)(C(C)CC)C2=O)C1 CHEMBL1917913 IC50 5.0 nM
CC(=O)N[C@@H](Cc1ccc(F)cc1)[C@H](O)CN[C@H]1CC2(CCC2)Oc2ncc(CC(C)(C)C)cc21 CHEMBL2030997 IC50 5.0 nM
C=CC[C@H](NC(C)=O)[C@H](O)CN[C@H]1C[C@]2(C[C@H](O)C2)Oc2ncc(CC(C)(C)C)cc21 CHEMBL2031151 IC50 5.0 nM
COCC(=O)N[C@@H](Cc1ccc(F)cc1)[C@H](O)CN[C@H]1CC2(CCC2)Oc2ncc(CC(C)(C)C)cc21 CHEMBL2171307 IC50 5.0 nM
COc1ccc(-c2nsc(C)c2C(=O)/N=C(\N)NCc2cc(C)c(NC(=O)CN3CCC3)c(Cl)c2)cc1 CHEMBL2178165 IC50 5.0 nM
COc1ccc(-c2nsc(C)c2C(=O)/N=C(\N)NCc2cc(Cl)c(NC(C)=O)c(Cl)c2)cc1 CHEMBL2178180 Ki 5.0 nM
NC1=N[C@@]2(CO1)c1cc(-c3cccnc3F)ccc1Oc1c(F)cc(N3CCOCC3)cc12 CHEMBL3354719 IC50 5.0 nM
C[C@]1(c2cc(NC(=O)c3cnc(C(F)F)cn3)ccc2F)N=C(N)OC[C@@H]1F CHEMBL3680867 IC50 5.0 nM
C[C@]1(c2cc(NC(=O)c3cnc(OCC4CC4)cn3)ccc2F)N=C(N)OC[C@@H]1F CHEMBL3680868 IC50 5.0 nM
Cc1noc(C)c1[C@@H]1C[C@@H](c2cc(NC(=O)c3ccc(Cl)cn3)ccc2F)N=C(N)S1 CHEMBL3806050 IC50 5.0 nM
CO[C@H]1CC[C@]2(CC1)Cc1ccc(C#CC3CC3)cc1C21N=C(N)N(CC(=O)O)C1=O CHEMBL3979180 IC50 5.0 nM
Cc1cc(C#N)cnc1C(=O)Nc1cccc([C@]2(C)CO[C@@](C)(C(F)(F)F)C(N)=N2)n1 CHEMBL3670353 IC50 5.0 nM
Cc1cc(Cl)cnc1C(=O)Nc1ccc(F)c([C@]2(CF)COCC(N)=N2)c1 CHEMBL3653509 IC50 5.0 nM
CC1=NC2(CC(C3CCOC(C)(C)C3)Oc3ccc(-c4cccc(Cl)c4)cc32)N=C1N CHEMBL3653708 IC50 5.0 nM
CC[C@@H]1C[C@]2(CC[C@H]1OC)Cc1ccc(C#N)cc1[C@]21N=C(N)N(CC2(F)CCOCC2)C1=O CHEMBL4113644 IC50 5.0 nM
CO[C@H]1CC[C@@]2(Cc3ccc(C#N)cc3[C@]23N=C(N)N(CC2(C)COC2)C3=O)C[C@@H]1C CHEMBL3929173 IC50 5.0 nM
CO[C@H]1[C@H](C)C[C@@]2(Cc3ccc(C#N)cc3[C@]23N=C(N)N(C[C@H]2CCCO2)C3=O)C[C@@H]1C CHEMBL4108996 IC50 5.0 nM
CO[C@H]1[C@H](C)C[C@@]2(Cc3ccc(C#N)cc3[C@]23N=C(N)N(C[C@@H]2COCCO2)C3=O)C[C@@H]1C CHEMBL4108178 IC50 5.0 nM
CO[C@H]1[C@H](C)C[C@@]2(Cc3ccc(C#N)cc3[C@]23N=C(N)N(Cc2ccncn2)C3=O)C[C@@H]1C CHEMBL4111446 IC50 5.0 nM
COc1cc(C#N)cc(-c2ccc3c(c2)C2(N=C(C)C(N)=N2)[C@]2(CC3)CC[C@@H](OC)CC2)c1 CHEMBL3672723 IC50 5.0 nM
COC1CCC2(CC1)Cc1ccc(-c3cc(F)cc(Cl)c3)cc1C21N=C(N)N2CC(F)(F)CN=C21 CHEMBL3673212 IC50 5.0 nM
COC1CCC2(CC1)Cc1ccc(C#CC3CC3)cc1C21N=C(N)c2c(F)cccc21 CHEMBL3673234 IC50 5.0 nM
C[C@@]1(c2cc(NC(=O)c3ncc(F)cc3F)ccc2F)CS(=O)(=O)C2(CC2)C(=N)N1 CHEMBL3973232 Ki 5.0 nM
COc1cnc(C(=O)Nc2ccc3c(c2)C2(CCOC(N)=N2)c2cc(C4CC4)nc(F)c2O3)cn1 CHEMBL3986979 IC50 5.0 nM
CC[C@H](C)Nc1cc(C(=O)N[C@@H](Cc2ccccc2)[C@H](O)[C@H]2CCCN2)cc(S(C)(=O)=O)n1 CHEMBL4066837 IC50 5.0 nM
C[C@@H]1OC[C@](c2cc(NC(=O)c3ccc(Br)cn3)ccc2F)(C(F)F)N=C1N CHEMBL3653410 IC50 5.0 nM
Cc1cc(C#N)cnc1C(=O)Nc1ccc(F)c([C@]2(C)CO[C@@](C)(C(F)(F)F)C(N)=N2)c1 CHEMBL3261067 IC50 5.0 nM
CN=[S@@]1(=O)C[C@@](C)(c2cc(NC(=O)c3ccc(Cl)cn3)ccc2F)N=C(N)N1C CHEMBL4534877 Ki 5.0 nM
C[C@H]1C[C@H]2CSC(N)=N[C@@]2(c2nc(NC(=O)c3ccc(OC(F)F)cn3)cs2)CO1 CHEMBL3952064 IC50 5.0 nM
C[C@@]1(c2cc(NC(=O)c3ncc(C#N)cc3N)ccc2F)CO[C@@](C)(C(F)(F)F)C(N)=N1 CHEMBL5090563 IC50 5.0 nM
COc1cnc(C(=O)Nc2ccc(F)c([C@]3(C)CS(=O)(=O)[C@@](C)(CF)C(=N)N3)c2)cn1 CHEMBL5208596 Ki 5.0 nM
COc1cc(-c2nc3ccc(Cl)cn3c2NC2CCCCC2)ccc1OCCCN1C(=O)c2ccccc2C1=O CHEMBL4208354 Ki 5.03 nM
CN1C(=N)N[C@@]2(c3cc(NC(=O)c4ccc(Cl)cn4)ccc3F)COC[C@H]2S1(=O)=O CHEMBL4114170 Ki 5.07 nM
CC(C)(C)Cc1cnc2c(c1)[C@@H](NC[C@@H](O)[C@@H]1Cc3cccc(c3)CCCCn3cc(ccc3=O)C(=O)N1)CC1(CCC1)O2 CHEMBL2407491 IC50 5.1 nM
CN1C(=O)[C@]2(N=C1N)c1cc(-c3cccnc3F)ccc1O[C@H]1CCOC[C@@]12C CHEMBL3127080 IC50 5.1 nM
COC1CCC2(CC1)Cc1ccc(C#CCC(C)C)cc1[C@]21N=C(N)N(C)C1=O CHEMBL4113779 IC50 5.1 nM
NC1=NC2(CCO1)c1cc(NC(=O)c3ccc(Cl)cn3)ccc1Oc1ncc(C3=CCCOC3)cc12 CHEMBL3917225 IC50 5.1 nM
CCC[C@@H](O)[C@H]1CCN([C@@H](CCc2ccccc2)C(=O)N[C@@H](Cc2cc(F)cc(F)c2)[C@H](O)CNCc2cccc(OC)c2)C1=O CHEMBL1915978 IC50 5.2 nM
COCC(=O)N[C@@H](Cc1cccc(-c2cncs2)c1)[C@H](O)CN[C@H]1CC2(CCC2)Oc2ncc(CC(C)(C)C)cc21 CHEMBL2181893 IC50 5.2 nM
C[C@]1(c2cc(NC(=O)c3ccc(Cl)cn3)ccc2F)N=C(N)CO[C@@H]1F CHEMBL3634340 IC50 5.2 nM
CO[C@H]1CC[C@]2(CC1)Cc1ccc(-c3cc(C#N)cc(C#N)c3)cc1C21N=C(C)C(N)=N1 CHEMBL3972170 IC50 5.2 nM
COC1CCC2(CC1)Oc1ccc(-c3cncc(Cl)c3)cc1C21N=C(C)C(N)=N1 CHEMBL3653698 IC50 5.2 nM
COc1ccc(C(=O)Nc2ccc(F)c([C@]3(C)CS(=O)(=O)C4(CCCC4)C(=N)N3)c2)nc1 CHEMBL3942552 Ki 5.2 nM
[C-]#[N+]c1ccc(C(=O)Nc2ccc(F)c([C@]3(C)CS(=O)(=O)[C@@]4(CCOC4)C(=N)N3)c2)nc1 CHEMBL3969301 Ki 5.2 nM
CCCN1C(=O)C2(N=C1N)c1cc(C#CC3CC3)ccc1CC21CCC(OC)CC1 CHEMBL3958023 IC50 5.2 nM
C[C@@]1(c2cc(NC(=O)c3ccc(Cl)cn3)cc(F)c2F)C[C@@H](C(F)(F)F)OC(N)=N1 CHEMBL3931128 IC50 5.2 nM
CCc1nc(N2C[C@H]3C(=O)N(C)C(N)=N[C@@]3(c3ccc(F)cc3F)C2)nc(OC)c1F CHEMBL3640278 Ki 5.3 nM
CN1C(=O)C2(N=C1N)c1cc(-c3cccc(C#N)c3)ccc1CC21CCc2ccccc2CC1 CHEMBL3656148 IC50 5.3 nM
COC1CCC2(CC1)Oc1ccc(-c3cccc(Cl)c3)cc1C21N=C(C)C(N)=N1 CHEMBL3653697 IC50 5.3 nM
CCc1cc(C#N)cc(-c2ccc3c(c2)C2(N=C(C)C(N)=N2)[C@]2(CC[C@H](OC)CC2)C3)c1 CHEMBL3657419 IC50 5.3 nM
CN1OC2(N=C1N)c1cc(-c3cccnc3)ccc1CC21CCc2ccccc2CC1 CHEMBL3900416 IC50 5.3 nM
COC1CCC2(CC1)Cc1ccc(C#CC3CC3)cc1C21NC(N)N(CCF)C1=O CHEMBL3980499 IC50 5.3 nM
CC#Cc1cncc(-c2cccc([C@@]3(C4CC4)NC(=N)N(C)C3=O)c2)c1 CHEMBL2012070 Ki 5.4 nM
COCC(=O)N[C@@H](Cc1ccc2c(c1)OCO2)[C@H](O)CN[C@H]1CC2(CCC2)Oc2ncc(CC(C)(C)C)cc21 CHEMBL2181830 IC50 5.4 nM
CN1C(=O)[C@]2(N=C1N)c1cc(-c3cccnc3F)ccc1O[C@H]1CCOC[C@@H]12 CHEMBL3127106 IC50 5.4 nM
COc1cnc(C(=O)Nc2ccc(F)c([C@]3(C)COCC(N)=N3)c2)cn1 CHEMBL3634123 IC50 5.4 nM
C#CCOc1cnc(C(=O)Nc2cc(F)c(F)c([C@@]3(CF)N=C(N)O[C@@H]4C[C@@H]43)c2)cn1 CHEMBL3683793 IC50 5.4 nM
[C-]#[N+]c1ccc(C(=O)Nc2ccc(F)c([C@]3(C)CS(=O)(=O)C4(CCC4)C(=N)N3)c2)nc1 CHEMBL3911217 Ki 5.4 nM
COC1CCC2(CC1)Cc1ccc(CCC3CC3)cc1C21N=C(N)N(C)C1=O CHEMBL3973057 IC50 5.4 nM
COC1CCC2(CC1)Cc1ccc(C#CC3CC3)cc1C21N=C(N)N(Cc2cnc3ccccc3n2)C1=O CHEMBL3924244 IC50 5.4 nM
COc1cnc(C(=O)Nc2ccc3c(c2)C2(CCSC(N)=N2)c2cc(C4=CCOCC4)nc(F)c2O3)c(C)c1 CHEMBL3902076 IC50 5.4 nM
COc1cnc(C(=O)Nc2ccc(F)c([C@]3(C)CCSC(N)=N3)c2)cn1 CHEMBL4561732 IC50 5.4 nM
C[C@H]1SC(N)=N[C@](C)(c2cc(NC(=O)c3cnc(F)cn3)ccc2F)C12CC(F)(F)C2 CHEMBL4437405 IC50 5.4 nM
CC(=O)N[C@@H](Cc1ccc2c(c1)OCO2)[C@H](O)CN[C@H]1CC2(CCC2)Oc2ncc(CC(C)(C)C)cc21 CHEMBL2181887 IC50 5.5 nM
COCC(=O)N[C@@H](Cc1cccc(-c2nccn2C)c1)[C@H](O)CN[C@H]1CC2(CCC2)Oc2ncc(CC(C)(C)C)cc21 CHEMBL2181891 IC50 5.5 nM
CO[C@H](C)C(=O)N[C@@H](Cc1cccc(-c2nccs2)c1)[C@H](O)CN[C@H]1CC2(CCC2)Oc2ncc(CC(C)(C)C)cc21 CHEMBL2181911 IC50 5.5 nM
CO[C@H]1CC[C@]2(CC1)Cc1ccc(-c3cncc(F)c3)cc1C21N=C(C)C(N)=N1 CHEMBL3937468 IC50 5.5 nM
C[C@@]1(c2cc(NC(=O)c3ccc(F)cn3)ccc2F)CS(=O)(=O)C2(CC2)C(=N)N1 CHEMBL3936730 Ki 5.5 nM
CN1C(=N)N[C@](C)(c2sc(-c3ccc(F)c(-c4nnco4)c3)cc2Cl)CS1(=O)=O CHEMBL3928041 Ki 5.5 nM
CC1(C#Cc2cncc(-c3ccc4c(c3)[C@@]3(COC(N)=N3)c3cc(C5=CCOCC5)ncc3O4)c2)COC1 CHEMBL4279496 IC50 5.5 nM
C[C@@]1(c2cc(NC(=O)c3ccc(Cl)cn3)ccc2F)C=CSC(N)=N1 CHEMBL3639691 IC50 5.5 nM
COc1cnc(C(=O)Nc2ccc(F)c([C@]3(C)Cn4c(C#N)cnc4C(N)=N3)c2)cn1 CHEMBL5073381 IC50 5.5 nM
CC(C)[C@H](NC(=O)[C@@H](N)CNC(=O)c1[nH]c(=O)[nH]c(=O)c1F)C(=O)N[C@@H](CC1CCCCC1)C(=O)N[C@@H](Cc1ccccc1)[C@@H](O)C(=O)Nc1cccc(-c2nn[nH]n2)c1 CHEMBL255838 IC50 5.6 nM
NC1=N[C@@]2(CO1)c1cc(-c3cccnc3F)ccc1Oc1ncc(C3CCOCC3)cc12 CHEMBL3359754 IC50 5.6 nM
COc1nc(N2C[C@H]3C(=O)N(C)C(N)=N[C@@]3(c3cc(F)ccc3F)C2)nc(OC)c1F CHEMBL3640256 Ki 5.6 nM
COc1nc(N2C[C@H]3C(=O)N(C)C(N)=N[C@@]3(c3cc(F)ccc3F)C2)nc(C2CC2)c1F CHEMBL3640280 Ki 5.6 nM
CCc1nc(N2C[C@H]3C(=O)N(C)C(N)=N[C@@]3(c3cc(F)c(F)cc3F)C2)nc(OC)c1F CHEMBL3640268 Ki 5.6 nM
C#CCOc1cnc(C(=O)Nc2ccc(Cl)c([C@@]3(CF)N=C(N)O[C@@H]4C[C@@H]43)c2)cn1 CHEMBL3688704 IC50 5.6 nM
C[C@@]1(c2cc(NC(=O)c3ccc(OCF)cn3)ccc2F)C[C@@H](C(F)(F)F)SC(N)=N1 CHEMBL4445405 IC50 5.67 nM
CCCO[C@H]1CN[C@@H]([C@@H](O)[C@H](Cc2cc(F)cc(F)c2)NC(=O)[C@H](CCc2ccccc2)N2CC[C@H](CC(C)C)C2=O)C1 CHEMBL1915994 IC50 5.7 nM
CCOCC(=O)N[C@@H](Cc1cccc(-c2nccs2)c1)[C@H](O)CN[C@H]1CC2(CCC2)Oc2ncc(CC(C)(C)C)cc21 CHEMBL2181910 IC50 5.7 nM
COCC(=O)N[C@@H](Cc1cccc(-c2nc(C)cs2)c1)[C@H](O)CN[C@H]1CC2(CCC2)Oc2ncc(CC(C)(C)C)cc21 CHEMBL2181895 IC50 5.7 nM
CN1C(=O)[C@]2(N=C1N)c1cc(-c3cccnc3F)ccc1O[C@@]1(C)CCCO[C@@H]12 CHEMBL3357658 IC50 5.7 nM
COC1CCC2(CCc3ccc(-c4cc(Cl)cc(C#N)c4)cc3C23N=C(C)C(N)=N3)CC1 CHEMBL3672730 IC50 5.7 nM
CC#CCOc1ccc(C(=O)Nc2ccc(F)c([C@@]3(C(F)F)N=C(N)O[C@@H]4C[C@@H]43)c2)nc1 CHEMBL3688661 IC50 5.7 nM
C[C@@]1(c2cc(NC(=O)c3ncc(Cl)cc3C#N)ccc2F)CS(=O)(=O)[C@]2(CCOC2)C(=N)N1 CHEMBL3978379 Ki 5.7 nM
CC1(C)Oc2ccc(NC(=O)c3ccc(C#N)cn3)cc2C2(COC(N)=N2)C12COC2 CHEMBL3650828 IC50 5.7 nM
C[C@@]1(c2cc(NC(=O)c3ncc(C#N)cc3Cl)cc(F)c2F)C[C@@H](C(F)(F)F)OC(N)=N1 CHEMBL3916872 IC50 5.7 nM
COc1ccc(C(=O)Nc2ccc(F)c([C@]34COC[C@H]3S(=O)(=O)C(C)(C)C(=N)N4)c2)nc1 CHEMBL4108703 Ki 5.8 nM
C[C@@]1(c2cc(NC(=O)c3coc(CF)n3)ccc2F)C=C(CF)OC(N)=N1 CHEMBL4207430 IC50 5.8 nM
O=C1Cc2cc(N3C(=O)c4ccccc4C3=O)ccc2CN1C(=O)c1ccccc1 CHEMBL5279409 IC50 5.87 nM
COc1ncc(Cc2c(C)noc2C)c2c1C[C@]1(c3ccc(F)cc3F)N=C(N)SC[C@@H]1C2 CHEMBL4520734 pIC50 5.888 nM
CC(C)C[C@H](NC(=O)C(CC(N)=O)NC(=O)[C@@H](NC(=O)OC(C)(C)C)C(C)C)C(O)CC(C)C(=O)NC(C(=O)NCc1ccccc1)C(C)C CHEMBL304010 Ki 5.9 nM
CC(C)C[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)OC(C)(C)C)C(C)C)[C@@H](O)C[C@@H](C)C(=O)N[C@H](C(=O)NCc1ccccc1)C(C)C CHEMBL98238 Ki 5.9 nM
CC(C)C[C@H](NC(=O)C(NC(=O)[C@@H](NC(=O)OC(C)(C)C)C(C)C)C(N)=O)C(O)CC(C)C(=O)N[C@H](C(=O)NCc1ccccc1)C(C)C CHEMBL189358 Ki 5.9 nM
CC(C)(C)Cc1cnc2c(c1)[C@@H](NC[C@@H](O)[C@H](Cc1cccc(-c3nccs3)c1)NC(=O)[C@@H]1CCCO1)CC1(CCC1)O2 CHEMBL2181916 IC50 5.9 nM
CC(C)(C)Cc1cnc2c(c1)[C@@H](NC[C@@H](O)[C@@H]1Cc3cccc(c3)CCCCCCC(=O)N1)CC1(CCC1)O2 CHEMBL2407487 IC50 5.9 nM
CCc1ccc2c(c1)[C@@H](NC[C@@H](O)[C@@H]1Cc3cccc(c3)CCCCn3cc(cc(-c4ccccn4)c3=O)C(=O)N1)CC1(CCC1)O2 CHEMBL2407489 IC50 5.9 nM
COc1cc(Cl)cc(-c2ccc3c(c2)C2(N=C(N)N(C)O2)C2(CCC(OC)CC2)C3)c1 CHEMBL3656128 IC50 5.9 nM
COC1CCC2(CC1)Cc1ccc(-c3cc(F)cc(C#N)c3)cc1C21N=C(N)N(C)O1 CHEMBL3656129 IC50 5.9 nM
CO[C@H]1CC[C@]2(CC1)Cc1ccc(-c3cnc(C)c(Cl)c3)cc1[C@@]21N=C(C)C(N)=N1 CHEMBL3902314 IC50 5.9 nM
CO[C@H]1CC[C@]2(CC1)Cc1ccc(C#CC3CC3)cc1[C@]21N=C(N)c2ccc(C#N)cc21 CHEMBL4110087 IC50 5.9 nM
C[C@@]1(c2cc(NC(=O)c3ccc(Cl)cn3)ccc2F)CS(=O)(=O)[C@@]2(CCOC2)C(=N)N1 CHEMBL3919398 Ki 5.9 nM
[2H]C1([2H])OC(N)=N[C@]12c1cc(-c3cncc(C)c3)ccc1C[C@]21CC[C@@H](OC)CC1 CHEMBL4093123 IC50 5.9 nM
C[C@@]1(c2cc(-c3cc4c(cn3)OC(F)(F)O4)ccc2F)CC[C@@](C)(S(=O)(=O)C(F)(F)F)C(N)=N1 CHEMBL5184228 IC50 5.9 nM
CCCCS(=O)(=O)C[C@@H](NC(C)=O)C(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)CNCc1cccc(CC)c1 CHEMBL232490 EC50 6.0 nM
COCCN(C[C@H]1C[C@@H]1C)c1cc(C(=O)N[C@@H](Cc2ccccc2)[C@@H](N)COC)cc(N(C)S(=O)(=O)C(C)C)n1 CHEMBL429477 IC50 6.0 nM
CCNc1cc(C(=O)N[C@@H](Cc2ccccc2)[C@H](O)CNCc2cnn(CC)c2)c(F)c(N2CCCCS2(=O)=O)c1 CHEMBL254485 IC50 6.0 nM
CCOc1cc(C(=O)N[C@@H](Cc2ccccc2)[C@H](O)CNCc2cccc(C(F)(F)F)c2)cc(N2CCCCS2(=O)=O)c1 CHEMBL253867 IC50 6.0 nM
CCCN(CCC)C(=O)c1cc(C)cc(C(=O)N[C@@H](Cc2cc(F)cc(F)c2)[C@H](O)[C@H]2C[C@@H](OCC3CC3)CCN2)c1 CHEMBL404078 IC50 6.0 nM
CCNc1cc(C(=O)N[C@@H](Cc2ccccc2)[C@H](O)CNC(C)(C)c2cccc(C(F)(F)F)c2)cc(N2CCCCS2(=O)=O)c1 CHEMBL510798 IC50 6.0 nM
CCCO/N=C(/C)c1cc(C(=O)N[C@@H](Cc2cc(F)cc(F)c2)[C@H](O)CNCc2cccc(OC)c2)cc(N(c2ccccc2)S(C)(=O)=O)c1 CHEMBL541739 IC50 6.0 nM
CS(=O)(=O)N(c1ccccc1)c1cc(C(=O)N[C@@H](Cc2ccccc2)[C@H](O)CNCc2cccc(C(F)(F)F)c2)cc(N2CCCC2=O)c1 CHEMBL1210363 IC50 6.0 nM
CC(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)CNC1(c2cn(C[Si](C)(C)C)nn2)CCCCC1 CHEMBL1257184 ED50 6.0 nM
CC(=O)N[C@@H](Cc1ccc(F)cc1)[C@H](O)CN[C@H]1C[C@]2(C[C@H](F)C2)Oc2ncc(CC(C)(C)C)cc21 CHEMBL2030995 IC50 6.0 nM
CC(C)(C)c1cccc(CN[C@H]2CS(=O)(=O)C[C@@H](Cc3cc(F)c(N)c(OCC(F)F)c3)[C@@H]2O)c1 CHEMBL2048044 IC50 6.0 nM
CC(C)(C)c1cccc(CN[C@H]2CS(=O)(=O)C[C@@H](Cc3cc(F)c(N)c(OCC(F)(F)F)c3)[C@@H]2O)c1 CHEMBL2048045 IC50 6.0 nM
CC1(C)OCc2ccc(CN[C@H]3CS(=O)(=O)C[C@@H](Cc4cc(F)c(N)c(OC(C(F)(F)F)C(F)(F)F)c4)[C@@H]3O)cc21 CHEMBL2048060 IC50 6.0 nM
CN1C(=N)N[C@@]2(c3cc(-c4cccc(C#N)c4)cs3)CN(c3ccc(F)cn3)C[C@H]2C1=O CHEMBL2178714 Ki 6.0 nM
CN1C(=N)N[C@@]2(c3cc(-c4cccc(C#N)c4)cs3)CN(c3ncccc3C#N)C[C@H]2C1=O CHEMBL2178713 Ki 6.0 nM
COc1ccc(-c2nsc(C)c2C(=O)/N=C(\N)NCc2cc(Cl)c(NC(=O)CNCc3ccccc3)c(Cl)c2)cc1 CHEMBL2178195 Ki 6.0 nM
CC(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)CN[C@H]1CC(C)(C)Oc2ccc(CC(C)(C)C#N)cc21 CHEMBL2408757 IC50 6.0 nM
CCC[C@@]1(C)C[C@H](NC[C@@H](O)[C@H](Cc2cc(F)cc(F)c2)NC(C)=O)c2cc(CC(C)(C)C)ccc2O1 CHEMBL2408751 IC50 6.0 nM
CC(C)(C)COc1ccc2c(c1)[C@]1(COC(N)=N1)c1cc(-c3ccc(F)nc3)ccc1O2 CHEMBL3354705 IC50 6.0 nM
Cc1coc([C@H]2C[C@H]3[C@@H](C)SC(N)=N[C@@]3(c3ccc(F)cc3F)CO2)n1 CHEMBL3422241 IC50 6.0 nM
Cc1cc([C@H]2C[C@H]3[C@@H](C)SC(N)=N[C@@]3(c3ccc(F)cc3F)CO2)on1 CHEMBL3422242 IC50 6.0 nM
COc1nc(N2C[C@H]3C(=O)N(C)C(N)=N[C@@]3(c3ccccc3F)C2)nc(C)c1F CHEMBL3640262 Ki 6.0 nM
Cc1cc(Cl)cnc1C(=O)Nc1ccc(F)c([C@]2(C(F)F)COCC(N)=N2)c1 CHEMBL3653510 IC50 6.0 nM
CO[C@H]1CC[C@]2(CC1)Cc1ccc(Oc3cc(Cl)cc(Cl)c3)cc1C21N=C(N)N(C)C1=O CHEMBL3908843 IC50 6.0 nM
C[C@@]1(c2nc(NC(=O)c3ncc(C#N)cc3Cl)ccc2F)CO[C@@](C)(C(F)(F)F)C(N)=N1 CHEMBL3670365 IC50 6.0 nM
Cc1c(C(=O)Nc2ccc(F)c([C@]3(C(F)F)COCC(N)=N3)c2)oc2ccc(Br)cc12 CHEMBL3653443 IC50 6.0 nM
CO[C@H]1[C@H](C)C[C@@]2(Cc3ccc(C#N)cc3[C@]23N=C(N)N(CCC2COC2)C3=O)C[C@@H]1C CHEMBL4106537 IC50 6.0 nM
CO[C@H]1CC[C@@]2(Cc3ccc(C#N)cc3[C@]23N=C(N)N(CC2COCCO2)C3=O)C[C@@H]1C CHEMBL3921692 IC50 6.0 nM
COC1CCC2(CC1)Cc1ccc(-c3cccc(C#N)c3)cc1C21N=C(N)c2ccccc21 CHEMBL3673221 IC50 6.0 nM
C#CCOc1ccc(C(=O)Nc2cc(F)c(Cl)c([C@]3(CF)N=C(N)O[C@H]4C[C@H]43)c2)nc1 CHEMBL3683890 IC50 6.0 nM
COCCN1C(=O)[C@]2(N=C1N)c1cc(C#CC3CC3)ccc1C[C@]21CC[C@@H](OC)CC1 CHEMBL4115567 IC50 6.0 nM
Cc1cc([C@H]2C[C@H]3CSC(N)=N[C@@]3(c3ccc(F)cc3F)CO2)ccc1F CHEMBL3906147 IC50 6.0 nM
NC1=N[C@@]2(c3ccc(F)cc3F)CO[C@@H](c3ccc4c(c3)CCO4)C[C@H]2CS1 CHEMBL3935755 IC50 6.0 nM
CC#CCOc1cnc(C(=O)Nc2cc(F)c(F)c([C@]3(C)C[C@@H](C(F)(F)F)OC(N)=N3)c2)c(C)c1 CHEMBL3960890 IC50 6.0 nM
C[C@@]1(c2cc(NC(=O)c3ccc(C#N)cn3)cc(F)c2Cl)C[C@@H](C(F)(F)F)OC(N)=N1 CHEMBL3926258 IC50 6.0 nM
NC1=N[C@@]2(c3cc(NC(=O)c4ccc(OC(F)F)cn4)ccc3F)CO[C@@H](C(F)(F)F)C[C@H]2CS1 CHEMBL3904953 IC50 6.0 nM
Cc1nc(C(=O)Nc2ccc(F)c([C@]34COC[C@H]3S(=O)(=O)C(C)(C)C(=N)N4)c2)c(C)o1 CHEMBL4112190 Ki 6.0 nM
CNS1(O)C[C@@](C)(c2cc(NC(=O)c3cnc(OC)cn3)ccc2F)NC(=N)C1(C)C CHEMBL3962501 Ki 6.0 nM
COCCNCc1cc([C@]2(C)CCSC(N)=N2)c(F)cc1F CHEMBL4092406 IC50 6.0 nM
C[C@]1(c2cc(NC(=O)c3ccc(C#N)cn3)ccc2F)N=C(N)CO[C@H]1C(F)(F)F CHEMBL4165225 IC50 6.0 nM
COC[C@]12C[C@H]1[C@@](CF)(c1cc(NC(=O)c3ccc(Cl)cn3)ccc1F)N=C(N)S2 CHEMBL4760131 IC50 6.0 nM
C[C@@]1(c2nc(NC(=O)c3ncc(C#N)cc3N)ccc2F)CO[C@@](C)(C(F)(F)F)C(N)=N1 CHEMBL3670368 IC50 6.0 nM
C[C@@]1(c2cc(NC(=O)c3ccc(C#N)cn3)ccc2F)CO[C@@](C)(C(F)(F)F)C(N)=N1 CHEMBL3653405 IC50 6.0 nM
C[C@@]1(c2cc(NC(=O)c3ncc(C#N)cc3Cl)ccc2F)CO[C@@](C)(C(F)(F)F)C(N)=N1 CHEMBL5073160 IC50 6.0 nM
C[C@@]1(c2cc(NC(=O)c3ccc(C#N)cn3)ccc2F)Cn2ncnc2C(N)=N1 CHEMBL4438397 pIC50 6.026 nM
COCC(=O)N[C@@H](Cc1ccc(F)c(-c2nccs2)c1)[C@H](O)CN[C@H]1CC2(CCC2)Oc2ncc(CC(C)(C)C)cc21 CHEMBL2181901 IC50 6.1 nM
CCc1nc(N2C[C@H]3C(=O)N(C)C(N)=N[C@@]3(c3ccc(F)cc3)C2)nc(OC)c1F CHEMBL3640276 Ki 6.1 nM
COc1nc(N2C[C@H]3C(=O)N(C)C(N)=N[C@@]3(c3cc(F)ccc3F)C2)nc(C)c1F CHEMBL3261082 Ki 6.1 nM
CO[C@H]1CC[C@]2(CC1)Cc1ccc(OCC3CCC3)cc1C21N=C(C)C(N)=N1 CHEMBL3961886 IC50 6.1 nM
C[C@@]1(c2cc(NC(=O)c3ccc(Cl)cn3)ccc2F)CS(=O)(=O)C2(CCOCC2)C(=N)N1 CHEMBL3983399 Ki 6.1 nM
[C-]#[N+]c1ccc(C(=O)Nc2ccc(F)c([C@]3(C)CS(=O)(=O)[C@]4(CCOC4)C(=N)N3)c2)nc1 CHEMBL3896325 Ki 6.1 nM
COc1cc(C#N)cnc1C(=O)Nc1cc(F)c(F)c([C@]2(C)C[C@@H](C(F)(F)F)OC(N)=N2)c1 CHEMBL3944783 IC50 6.1 nM
NC1=N[C@@](c2cc(NC(=O)c3ccc(Br)cn3)ccc2F)(C(F)F)C(F)(F)CC1 CHEMBL3915809 Ki 6.1 nM
CN1CC2(C1)C(=N)N[C@](C)(c1cc(NC(=O)c3ccc(F)cn3)ccc1F)CS2(=O)=O CHEMBL3975362 Ki 6.1 nM
COC[C@]12C[C@H]1[C@@](C)(c1cc(NC(=O)c3ccc(OCC(F)(F)F)cn3)cc(F)c1F)N=C(N)S2 CHEMBL4461994 IC50 6.1 nM
CC(F)(F)[C@@H]1C[C@@](C)(c2cc(NC(=O)c3ccc(OCF)cn3)ccc2F)N=C(N)S1 CHEMBL4475802 IC50 6.13 nM
COCCCOc1ccc2c(c1)C1(N=C(N)N(CC(F)F)C1=O)[C@]1(CC[C@H](OC)CC1)C2 CHEMBL3656276 IC50 6.2 nM
CCCN1C(=O)C2(N=C1N)c1cc(OCC3CC3)ccc1CC21CCC(OC)CC1 CHEMBL3936196 IC50 6.2 nM
Cc1onc2c1CC1(CC2)Cc2ccc(Br)cc2C12N=C(N)N(C)O2 CHEMBL3947739 IC50 6.2 nM
COc1cnc(C(=O)Nc2ccc3c(c2)C2(CCSC(N)=N2)c2cc(Cl)nc(F)c2O3)cn1 CHEMBL3976114 IC50 6.2 nM
COc1cnc(C(=O)Nc2ccc3c(c2)C2(CCSC(N)=N2)c2cc(C4=CCOCC4)cc(F)c2O3)cn1 CHEMBL3932872 IC50 6.2 nM
COc1cnc(C(=O)Nc2ccc(F)c([C@]34COC[C@H]3S(=O)(=O)C(C)(C)C(=N)N4)c2)cn1 CHEMBL4111329 Ki 6.2 nM
C[C@@]1(c2cc(NC(=O)c3cnc(OCF)cn3)ccc2F)C[C@@H](C(F)F)SC(N)=N1 CHEMBL4438526 IC50 6.23 nM
CC(C)(C)Cc1cnc2c(c1)[C@@H](NC[C@@H](O)[C@H](Cc1cccc(-c3nccs3)c1)NC(=O)[C@H]1CCCO1)CC1(CCC1)O2 CHEMBL2181915 IC50 6.3 nM
C[C@@H]1C[C@@]2(Cc3ccc(NC(=O)C(C)(C)F)cc3[C@]23N=C(N)N(CC(C)(C)F)C3=O)C[C@H](C)[C@H]1O CHEMBL4114265 IC50 6.3 nM
C#CCOc1cnc(C(=O)Nc2ccc(Cl)c([C@]3(C(F)F)N=C(N)O[C@H]4C[C@H]43)c2)cn1 CHEMBL3688649 IC50 6.3 nM
COc1cccc2cc(-c3cc(Cl)c([C@]4(C)CS(=O)(=O)[C@]5(CCOC5)C(=N)N4)s3)[nH]c12 CHEMBL3981858 Ki 6.3 nM
COCCOc1ccc2c(c1)[C@@]1(N=C(N)N(C)C1=O)C1(CCc3ccccc3CC1)C2 CHEMBL3896653 IC50 6.3 nM
COCCN1C(=O)C2(N=C1N)c1cc(-c3cccnc3F)ccc1CC21CCc2ccccc2CC1 CHEMBL3939930 IC50 6.3 nM
COc1ccc(C(=O)Nc2ccc(F)c([C@]3(C)CS(=O)(=O)C4(CN(C)C4)C(=N)N3)c2)nc1 CHEMBL3937168 Ki 6.3 nM
COc1cnc(C(=O)Nc2ccc(F)c([C@]3(C)CS(=O)(=O)C4(CN(C)C4)C(=N)N3)c2)c(C)c1 CHEMBL3917191 Ki 6.3 nM
C[C@@H]1O[C@@H](O[C@@H]2[C@@H](O)[C@H](OCCc3ccc(O)c(O)c3)O[C@H](CO)[C@H]2OC(=O)/C=C/c2ccc(O)c(O)c2)[C@H](O)[C@H](O)[C@H]1O CHEMBL444478 IC50 6.3 nM
C[C@@]1(c2cc(NC(=O)c3ccc(C#N)cn3)ccc2F)Cn2ccnc2C(N)=N1 CHEMBL4525199 pIC50 6.31 nM
CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)CCC(=O)O)C(C)C)C(=O)N[C@@H](Cc1ccccc1)[C@@H](O)C(=O)Nc1cc(-c2nn[nH]n2)cc(-c2nn[nH]n2)c1 CHEMBL205217 IC50 6.4 nM
CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)CNC(=O)c1nn[nH]n1)C(C)C)C(=O)N[C@@H](Cc1ccccc1)[C@@H](O)C(=O)Nc1cccc(-c2noc(S)n2)c1 CHEMBL208060 IC50 6.4 nM
CN1CCC2(CC1)C(=N)N[C@](C)(c1cc(NC(=O)c3ccc(C#N)cn3)ccc1F)CS2(=O)=O CHEMBL3900954 Ki 6.4 nM
C[C@]1(c2cc(NC(=O)c3ncc(C#N)cc3Cl)ccc2F)N=C(N)CO[C@H]1C(F)(F)F CHEMBL4169060 IC50 6.4 nM
CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)CNC(=O)c1[nH]c(=O)[nH]c(=O)c1F)C(C)C)C(=O)N[C@@H](Cc1ccccc1)[C@@H](O)C(=O)Nc1cccc(-c2nn[nH]n2)c1 CHEMBL380381 IC50 6.5 nM
CCC(C)[C@@]1(NC(C)=O)CCN([C@@H](CCc2ccccc2)C(=O)N[C@@H](Cc2cc(F)cc(F)c2)[C@H](O)[C@H]2C[C@@H](O)CN2)C1=O CHEMBL1916001 IC50 6.5 nM
CC(=O)N[C@@H](Cc1ccc(F)cc1F)[C@H](O)CN[C@H]1CC2(CCC2)Oc2ncc(CC(C)(C)C)cc21 CHEMBL2151236 IC50 6.5 nM
COc1nc(N2C[C@H]3C(=O)N(C)C(N)=N[C@@]3(c3cc(F)ccc3F)C2)nc(C2CC2)c1Cl CHEMBL3640281 Ki 6.5 nM
COC1CCC2(CC1)Cc1ccc(C#CC3CC3)cc1C21N=C(N)c2ccc(C(F)(F)F)cc21 CHEMBL3673232 IC50 6.5 nM
C[C@@]1(c2cc(NC(=O)c3ncc(Cl)cc3F)ccc2F)CS(=O)(=O)C2(CCOCC2)C(=N)N1 CHEMBL3969079 Ki 6.5 nM
COC1CCC2(CC1)Cc1ccc(OC(F)(F)C(F)F)cc1[C@]21N=C(N)N(C)C1=O CHEMBL4107172 IC50 6.5 nM
COc1cnc(C(=O)Nc2ccc3c(c2)C2(CCOC(N)=N2)c2cc(-c4ccnc(F)c4)cc(F)c2O3)cn1 CHEMBL3973933 IC50 6.5 nM
CN1C(=N)N[C@](C)(c2sc(-c3cccc(-c4ccno4)c3)cc2Cl)CS1(=O)=O CHEMBL3978736 Ki 6.5 nM
COc1ccc(C(=O)Nc2ccc(F)c([C@]3(C)CS(=O)(=O)C4(CN(S(C)(=O)=O)C4)C(=N)N3)c2)nc1 CHEMBL3926149 Ki 6.5 nM
C[C@@]1(c2cc(NC(=O)c3coc(C(F)F)n3)ccc2F)C=C(CF)OC(N)=N1 CHEMBL4212335 IC50 6.5 nM
C[C@]1(c2cc(NC(=O)c3cnc(OCF)cn3)ccc2F)N=C(N)SCC12CCOCC2 CHEMBL4583340 Ki 6.5 nM
CCCC(O)C(NCC(O)C(Cc1ccccc1)NC(=O)c1cc(C)cc(C(=O)N2CCCC2OC)c1)C(=O)NCC(C)C CHEMBL3664021 Ki 6.56 nM
CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)CNC(=O)c1nn[nH]n1)C(C)C)C(=O)N[C@@H](Cc1ccccc1)[C@@H](O)C(=O)Nc1cccc(-c2noc(O)n2)c1 CHEMBL205333 IC50 6.6 nM
CC(C)[C@H](NC(=O)[C@H](C)C[C@H](O)[C@H](COCc1cc(F)cc(F)c1)NC(=O)c1cc(C(=O)N[C@H](C)c2ccccc2)cc(N(C)S(C)(=O)=O)c1)C(=O)NCc1ccccc1 CHEMBL1076902 IC50 6.6 nM
CC(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)CN[C@H]1CC2(CCC2)Oc2ncc(CC(C)(C)C)cc21 CHEMBL2030998 IC50 6.6 nM
C#CCOc1cnc(C(=O)Nc2ccc(F)c([C@@]3(CF)N=C(N)O[C@@H]4C[C@@H]43)c2)cn1 CHEMBL3688628 IC50 6.6 nM
C[C@@]1(c2cc(NC(=O)c3ccc(Br)cn3)cc(F)c2F)C[C@@H](C(F)(F)F)OC(N)=N1 CHEMBL3910073 IC50 6.6 nM
C[C@@]1(c2cc(NC(=O)c3ncc(OCF)nc3N)ccc2F)C=C(CF)OC(N)=N1 CHEMBL4211790 IC50 6.6 nM
C[C@@]1(c2cc(NC(=O)c3ccc(C#N)cn3)ccc2F)Cn2cnnc2C(N)=N1 CHEMBL4473647 pIC50 6.607 nM
[C-]#[N+]c1ccc(C(=O)Nc2ccc(F)c([C@]34COC[C@@]3(F)CSC(N)=N4)c2)nc1 CHEMBL3672943 IC50 6.66 nM
N#Cc1ccc(C(=O)Nc2ccc(F)c([C@]34COC[C@@]3(F)CSC(N)=N4)c2)nc1 CHEMBL4546682 IC50 6.66 nM
COc1ccc2c(c1)C1(N=C(N)N(C)C1=O)c1cc(NC(=O)c3ccc(Cl)cn3)ccc1O2 CHEMBL3695754 IC50 6.7 nM
CC1=NC2(N=C1N)c1cc(Br)ccc1C[C@]21CC[C@@H](O)CC1 CHEMBL3672687 IC50 6.7 nM
CO[C@H]1CC[C@]2(CC1)Cc1ccc(OCC(C)F)cc1C21N=C(C)C(N)=N1 CHEMBL3899321 IC50 6.7 nM
CN1C(=O)C2(N=C1N)c1cc(-c3cccnc3F)ccc1CC21CCc2ccccc2CC1 CHEMBL3916104 IC50 6.7 nM
COc1ccc(C(=O)Nc2ccc(F)c([C@@]3(C(F)F)N=C(N)CCC3(F)F)c2)nc1 CHEMBL3969624 Ki 6.7 nM
CN1C(=N)N[C@](C)(c2sc(-c3ccc(F)c(-c4nnco4)c3)cc2F)CS1(=O)=O CHEMBL3891075 Ki 6.7 nM
CN1C(=O)[C@]2(N=C1N)c1cc(-c3cccc(C#N)c3)ccc1O[C@H]1CCOC[C@@]12C CHEMBL3127079 IC50 6.8 nM
COc1nc(N2C[C@H]3C(=O)N(C)C(N)=N[C@@]3(c3ccc(F)cc3F)C2)nc(C2CC2)c1Cl CHEMBL3640265 Ki 6.8 nM
C[C@H]1C[C@@]2(CC[C@@H]1O)Cc1ccc(-c3cccnc3)cc1[C@]21N=C(N)N(Cc2ncccn2)C1=O CHEMBL3921904 IC50 6.8 nM
CN1C(=O)C2(N=C1N)c1cc(CCC3CC3)ccc1OC21CCc2ccccc2CC1 CHEMBL3906323 IC50 6.8 nM
COC1CCC2(CC1)Cc1ccc(OCC3CC3)cc1C21NC(N)N(CCF)C1=O CHEMBL3941308 IC50 6.8 nM
Cc1cc(C#N)cnc1C(=O)Nc1cc(F)c(F)c([C@]2(C)C[C@@H](C(F)(F)F)OC(N)=N2)c1 CHEMBL3940163 IC50 6.8 nM
NC1=NC2(CCO1)c1cc(NC(=O)c3ccc(Cl)cn3)ccc1Oc1c2cc(Cl)nc1F CHEMBL3948764 IC50 6.8 nM
COc1cnc(C(=O)Nc2ccc3c(c2)C2(CCOC(N)=N2)c2cc(C4CC4)ncc2O3)cn1 CHEMBL3893589 IC50 6.8 nM
COc1cnc(C(=O)Nc2ccc3c(c2)C2(CCOC(N)=N2)c2cc(C4=CCCOC4)cc(F)c2O3)cn1 CHEMBL3976447 IC50 6.8 nM
CC(C)S(=O)(=O)[C@]1(C)CC[C@@](CF)(c2cc(NC(=O)c3cc4c(cn3)OC(F)(F)O4)ccc2F)N=C1N CHEMBL5089679 IC50 6.8 nM
CC(C)c1cccc(CNC[C@@H](O)[C@@H]2COC/C=C\CCN(C)C(=O)c3cc(cc(N(C)S(C)(=O)=O)c3)C(=O)N2)c1 CHEMBL2047039 IC50 6.9 nM
COCC(=O)N[C@@H](Cc1cccc(-c2cscn2)c1)[C@H](O)CN[C@H]1CC2(CCC2)Oc2ncc(CC(C)(C)C)cc21 CHEMBL2181894 IC50 6.9 nM
CCc1nc(N2C[C@H]3C(=O)N(C)C(N)=N[C@@]3(c3cc(F)ccc3F)C2)nc(OC)c1F CHEMBL3640277 Ki 6.9 nM
COc1cnc(C(=O)Oc2ccc(F)c([C@@]3(C(F)F)N=C(N)CCC3(F)F)c2)nc1 CHEMBL3963413 Ki 6.9 nM
CN1C(=N)N[C@](C)(c2sc(-c3cncc(-c4ncco4)c3)cc2Cl)CS1(=O)=O CHEMBL3962846 Ki 6.9 nM
CN1C(=N)N[C@](C)(c2sc(-c3cccc(-c4ccno4)c3)cc2F)CS1(=O)=O CHEMBL3892917 Ki 6.9 nM
COc1ccc(C(=O)Nc2ccc(F)c([C@]3(C)CC[C@@](C)(C#N)C(N)=N3)c2)nc1 CHEMBL4556248 IC50 6.9 nM
CC[C@H](NC[C@H](Cc1ccccc1)NC(=O)c1cc(C(=O)N[C@H](C)c2ccc(F)cc2)cc(N(C)S(C)(=O)=O)c1)C(=O)NCC(C)C CHEMBL209372 IC50 7.0 nM
CCCCO[C@H]1CCN[C@@H]([C@@H](O)[C@H](Cc2cc(F)cc(F)c2)NC(=O)c2cc(C)cc(C(=O)N(CCC)CCC)c2)C1 CHEMBL399979 IC50 7.0 nM
CCCN(CCC)C(=O)c1cc(C)cc(C(=O)N[C@@H](Cc2cc(F)cc(F)c2)[C@H](O)[C@H]2C[C@@H](OCC)CCN2)c1 CHEMBL257278 IC50 7.0 nM
CCc1cn2c3c(cc(C(=O)N[C@@H](Cc4ccccc4)[C@H](O)CNC4CCCCC4)cc13)N(CC)S(=O)(=O)CC2 CHEMBL558582 IC50 7.0 nM
CCc1cn2c3c(cc(C(=O)N[C@@H](Cc4ccccc4)[C@H](O)CNCCC(F)(F)F)cc13)N(C)S(=O)(=O)CC2 CHEMBL560092 IC50 7.0 nM
CCCN(CCC)C(=O)c1cc(C)cc(C(=O)N[C@@H](Cc2cc(F)cc(F)c2)[C@H](O)[C@H]2CN(S(=O)(=O)c3cccc(Cl)c3)CCN2)c1 CHEMBL1097324 Ki 7.0 nM
CCCN(CCC)C(=O)c1cc(C)cc(C(=O)N[C@@H](Cc2cc(F)cc(F)c2)[C@H](O)[C@H]2CN(S(=O)(=O)c3cn(C)cn3)CCN2)c1 CHEMBL1097332 Ki 7.0 nM
COC[C@H]1CCCN1C(=O)c1cc(C)cc(C(=O)N[C@@H](Cc2cc(F)cc(F)c2)[C@H](O)[C@H]2CN(S(=O)(=O)C3CC3)CCN2)c1 CHEMBL1097354 Ki 7.0 nM
CC(=O)N[C@@H](Cc1ccc(F)cc1)[C@H](O)CN[C@H]1C[C@]2(CC[C@@H]2C)Oc2ncc(CC(C)(C)C)cc21 CHEMBL2031000 IC50 7.0 nM
CC(C)(C)Cc1cc(CN[C@H]2CS(=O)(=O)C[C@@H](Cc3cc(F)c(N)c(OC(C(F)(F)F)C(F)(F)F)c3)[C@@H]2O)no1 CHEMBL2048063 IC50 7.0 nM
CN1C(=N)N[C@@]2(c3cc(-c4cccc(C#N)c4)cs3)CN(c3ncc(Cl)cn3)C[C@H]2C1=O CHEMBL2178719 Ki 7.0 nM
CC(C)(C)c1cccc(CN[C@H]2C[S@+]([O-])C[C@@H](Cc3cc(F)c(N)c(O[C@H](CO)C(F)(F)F)c3)[C@@H]2O)c1 CHEMBL2425613 IC50 7.0 nM
COC(C)(C)C#Cc1ccc2c(c1)[C@]1(COC(N)=N1)c1cc(-c3cncnc3)ccc1O2 CHEMBL3354692 IC50 7.0 nM
NC1=N[C@]2(CO1)c1cc(OCC3CCCCC3)ccc1Oc1ccc(-c3cncnc3)cc12 CHEMBL3354696 IC50 7.0 nM
CC(C)(O)COc1ccc2c(c1)[C@]1(COC(N)=N1)c1cc(-c3cncnc3)ccc1O2 CHEMBL3354697 IC50 7.0 nM
CC1(COc2ccc3c(c2)[C@]2(COC(N)=N2)c2cc(-c4cncnc4)ccc2O3)COC1 CHEMBL3354701 IC50 7.0 nM
CC1(COc2ccc3c(c2)[C@]2(COC(N)=N2)c2cc(-c4cccnc4)ccc2O3)COC1 CHEMBL3354711 IC50 7.0 nM
NC1=N[C@@]2(CO1)c1cc(-c3cccnc3F)ccc1Oc1c(F)cc(N3CC[C@H](F)C3)cc12 CHEMBL3354720 IC50 7.0 nM
Cn1cc([C@H]2C[C@H]3[C@@H](CF)SC(N)=N[C@@]3(c3ccc(F)cc3F)CO2)cn1 CHEMBL3422246 IC50 7.0 nM
COc1nc(N2C[C@H]3C(=O)N(C)C(N)=N[C@@]3(c3ccc(F)cc3)C2)nc(C)c1F CHEMBL3640263 Ki 7.0 nM
CO[C@H]1CC[C@]2(CC1)Cc1ccc(Oc3cccc(C#N)c3)cc1C21N=C(N)N(C)C1=O CHEMBL3982284 IC50 7.0 nM
COC1CCC2(CC1)Cc1ccc(-c3cccc(OC(F)(F)F)c3)cc1C21N=C(N)N(C)O1 CHEMBL3656130 IC50 7.0 nM
C[C@@]1(c2nc(NC(=O)c3ncc(Cl)cc3Cl)ccc2F)CO[C@@](C)(C(F)(F)F)C(N)=N1 CHEMBL3670372 IC50 7.0 nM
C[C@@]1(c2nc(NC(=O)c3ncc(C(F)(F)F)cc3Cl)ccc2F)CO[C@@](C)(C(F)(F)F)C(N)=N1 CHEMBL3670375 IC50 7.0 nM
Cc1c(C(=O)Nc2ccc(F)c([C@]3(C)C=CSC(N)=N3)c2)oc2ccc(Br)cc12 CHEMBL3670329 IC50 7.0 nM
COCc1cc(OC)nc(N2CC3[C@](c4cc(F)c(F)cc4F)(C2)NC(=N)N(C)S3(=O)=O)c1 CHEMBL4107294 Ki 7.0 nM
COCc1cc(OC)nc(N2CC3[C@](c4ccccc4F)(C2)NC(=N)N(C)S3(=O)=O)c1 CHEMBL4114606 Ki 7.0 nM
CCCCN1C(=O)C2(N=C1N)c1cc(OCC3CC3)ccc1CC21CCC(OC)CC1 CHEMBL3945122 IC50 7.0 nM
CN1C(=O)C2(NC1N)c1cc(OCC(F)(F)F)ccc1OC21CCc2ccccc2CC1 CHEMBL3931664 IC50 7.0 nM
Cc1noc2c1CC1(CC2)Cc2ccc(-c3cncc(Cl)c3)cc2C12N=C(N)N(C)O2 CHEMBL3894514 IC50 7.0 nM
CO[C@H]1CC[C@]2(CC1)Cc1ccc(OCC3CC3)cc1[C@]21N=C(N)N(CC(F)(F)F)C1=O CHEMBL4115521 IC50 7.0 nM
COC1CCC2(CC1)Cc1ccc(OCC(C)C)cc1C21N=C(N)N(CCF)C1=O CHEMBL3904189 IC50 7.0 nM
Cc1cc(NC(=O)c2ccc(Cl)cn2)cc([C@]2(CF)C[C@@H](C(F)(F)F)OC(N)=N2)c1F CHEMBL3943009 IC50 7.0 nM
C[C@@]1(c2cc(NC(=O)c3nn(C(F)F)cc3Cl)cc(F)c2F)C[C@@H](C(F)(F)F)OC(N)=N1 CHEMBL3930009 IC50 7.0 nM
N#Cc1ccc(C(=O)Nc2ccc3c(c2)C2(CCOC(N)=N2)c2cc(Cl)nc(F)c2O3)nc1 CHEMBL3924457 IC50 7.0 nM
COc1nc(C2=CCOCC2)cc2c1Oc1ccc(NC(=O)c3ccc(Cl)cn3)cc1C21CCOC(N)=N1 CHEMBL3944050 IC50 7.0 nM
C[C@H]1C[C@H]2CSC(N)=NC2(c2nc(NC(=O)c3coc(CF)n3)cs2)CO1 CHEMBL3933666 IC50 7.0 nM
CC1(C)C(=N)N[C@@]2(c3cc(NC(=O)c4cnc(OCCF)cn4)ccc3F)COC[C@H]2S1(=O)=O CHEMBL4112989 Ki 7.0 nM
C[C@H]1OC[C@]2(c3cc(NC(=O)c4ccc(F)cn4)ccc3F)NC(=N)C(C)(C)S(=O)(=O)[C@H]12 CHEMBL4107780 Ki 7.0 nM
[2H]C1([2H])OC(N)=N[C@]12c1cc(-c3cccnc3)ccc1C[C@]21CC[C@@H](OC)CC1 CHEMBL4074071 IC50 7.0 nM
[2H]C1([2H])OC(N)=N[C@]12c1cc(-c3cncnc3)ccc1C[C@]21CC[C@@H](OC)CC1 CHEMBL4065448 IC50 7.0 nM
Cc1cc(C#N)cnc1C(=O)Nc1ccc(F)c([C@]2(C(F)F)COCC(N)=N2)c1 CHEMBL3653512 IC50 7.0 nM
C[C@H]1OC[C@]2(c3cc(NC(=O)c4cnc(C(F)F)cn4)ccc3F)N=C(N)SC[C@H]12 CHEMBL4204869 IC50 7.0 nM
CC(=O)[C@]12C[C@H]1[C@@](C)(c1cc(/C=C(\F)c3ccc(C#N)cn3)ccc1F)N=C(N)S2 CHEMBL4750159 IC50 7.0 nM
CC(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)CNC1(c2cccc(C3CCOC3)c2)CCCCC1 CHEMBL1209106 ED50 7.1 nM
NC1=N[C@@]2(CO1)c1cc(-c3cccnc3F)ccc1Oc1cnc(C3CCOCC3)cc12 CHEMBL3394042 IC50 7.1 nM
CO[C@H]1CC[C@]2(CC1)Cc1ccc(-c3ccc(F)c(C#N)c3)cc1C21N=C(C)C(N)=N1 CHEMBL3928450 IC50 7.1 nM
CCCCN1C(=O)C2(N=C1N)c1cc(C#CC3CC3)ccc1CC21CCC(OC)CC1 CHEMBL3910855 IC50 7.1 nM
CC(=O)N[C@@H](Cc1ccccc1)[C@H](O)CN[C@H]1CC2(CCC2)Oc2ccc(CC(C)(C)C)cc21 CHEMBL2151150 IC50 7.2 nM
CO[C@@H](C)C(=O)N[C@@H](Cc1cccc(-c2nccs2)c1)[C@H](O)CN[C@H]1CC2(CCC2)Oc2ncc(CC(C)(C)C)cc21 CHEMBL2181912 IC50 7.2 nM
CCc1cn2c3c(cc(C(=O)N[C@H](CN[C@H](C(=O)NCC(C)C)[C@H](C)O)Cc4ccccc4)cc13)N(C)S(=O)(=O)C1(CC1)C2 CHEMBL2179139 Ki 7.2 nM
COCCOc1ccc2c(c1)[C@]1(N=C(N)N(C)C1=O)C1(CCC(OC)CC1)C2 CHEMBL4114390 IC50 7.2 nM
C[C@]1(c2cc(NC(=O)c3ccc(C#N)cn3)ccc2F)N=C(N)CO[C@@H]1F CHEMBL3634342 IC50 7.2 nM
C[C@]1(c2cc(NC(=O)c3ccc(Cl)cn3)ccc2F)N=C(N)CO[C@H]1C(F)(F)F CHEMBL3261072 IC50 7.2 nM
C[C@H]1C[C@H]2CSC(N)=N[C@@]2(c2nc(NC(=O)c3cnc(OC(F)F)cn3)cs2)CO1 CHEMBL4204163 IC50 7.2 nM
C[C@@]1(c2cc(NC(=O)c3cnc(OCC(F)(F)F)cn3)ccc2F)CCSC(N)=N1 CHEMBL4536643 IC50 7.2 nM
C[C@@]1(c2cc(NC(=O)c3cnc(C(F)F)cn3)ccc2F)CCSC(N)=N1 CHEMBL4563915 IC50 7.2 nM
CCc1cn2c3c(cc(C(=O)N[C@H](CN[C@H](C(=O)NCC(C)C)[C@H](C)O)Cc4ccccc4)cc13)N(C)S(=O)(=O)CC2 CHEMBL2179136 Ki 7.3 nM
CN1C(=O)[C@]2(N=C1N)c1cc(-c3cccc(C#N)c3)ccc1O[C@H]1CCOC[C@@H]12 CHEMBL3127104 IC50 7.3 nM
CC#Cc1cncc(-c2ccc3c(c2)C2(N=C(C)C(N)=N2)C2(CCC(F)(F)CC2)C3)c1 CHEMBL3653695 IC50 7.3 nM
CCN1C(=O)C2(N=C1N)c1cc(-c3cccc(C#N)c3)ccc1CC21CCC(OC)CC1 CHEMBL3984225 IC50 7.3 nM
CC#Cc1cncc(-c2ccc3c(c2)C2(N=C(N)N(C)C2=O)C2(CCC(OC)CC2)C3)c1 CHEMBL3971649 IC50 7.3 nM
COC1CCC2(CC1)Cc1ccc(C#CC3CC3)cc1C21N=C(N)N(CC2CCO2)C1=O CHEMBL3963016 IC50 7.3 nM
CNC(=O)N1CC2(C1)C(=N)N[C@](C)(c1cc(NC(=O)c3ccc(OC)cn3)ccc1F)CS2(=O)=O CHEMBL3956741 Ki 7.3 nM
CN1OC2(N=C1N)c1cc(-c3cc(Cl)cc(C#N)c3)ccc1CC21CCc2ccccc2CC1 CHEMBL3656131 IC50 7.4 nM
CCC1=NC2(N=C1N)c1cc(-c3cccc(C#N)c3)ccc1C[C@]21CC[C@@H](OC)CC1 CHEMBL3653725 IC50 7.4 nM
CO[C@H]1CC[C@]2(CC1)Cc1ccc(OCC3CC3)cc1C21N=C(C)C(N)=N1 CHEMBL3923244 IC50 7.4 nM
CN1C(=O)C2(N=C1N)c1cc(C#N)ccc1CC21CCC(O)CC1 CHEMBL3948874 IC50 7.4 nM
COCCN1C(=O)C2(N=C1N)c1cc(-c3cccc(C#N)c3)ccc1CC21CCC(OC)CC1 CHEMBL3976150 IC50 7.4 nM
COCCCN1C(=O)C2(N=C1N)c1cc(CCC3CC3)ccc1CC21CCC(OC)CC1 CHEMBL3968144 IC50 7.4 nM
N#Cc1ccc(C(=O)Nc2ccc(F)c([C@@]3(C(F)F)N=C(N)CCC3(F)F)c2)nc1 CHEMBL3984388 Ki 7.4 nM
CO[C@H]1CC[C@]2(CC1)Cc1ccc(OCCC(F)(F)F)cc1C21N=C(C)C(N)=N1 CHEMBL3959097 IC50 7.5 nM
CCC1CN=C2N(C1)C(N)=NC21c2cc(-c3cc(F)cc(Cl)c3)ccc2CC12CCC(OC)CC2 CHEMBL3673214 IC50 7.5 nM
COc1cc2c(cn1)Oc1ccc(NC(=O)c3ccc(Cl)cn3)cc1[C@@]21COC(N)=N1 CHEMBL4287410 IC50 7.5 nM
NC1=N[C@@](c2cc(NC(=O)c3cnc(OCC#CC4CC4)cn3)ccc2F)(C(F)F)[C@H]2C[C@H]2O1 CHEMBL3693227 IC50 7.6 nM
CC(C)c1cccc(CNC[C@@H](O)[C@@H]2COCCCCCCNC(=O)c3cc(cc(N(C)S(C)(=O)=O)c3)C(=O)N2)c1 CHEMBL2047038 IC50 7.7 nM
COc1nc(N2C[C@H]3C(=O)N(C)C(N)=N[C@@]3(c3cc(F)c(F)cc3F)C2)nc(C)c1F CHEMBL3640255 Ki 7.7 nM
COc1cccc2cc(-c3cc(Cl)c([C@]4(C)CS(=O)(=O)C5(CCC5)C(=N)N4)s3)[nH]c12 CHEMBL3976028 Ki 7.7 nM
COc1ccc(C(=O)Nc2ccc(F)c([C@]3(C)CS(=O)(=O)C4(CN(Cc5ccccc5)C4)C(=N)N3)c2)nc1 CHEMBL3905233 Ki 7.7 nM
CC#Cc1cncc(-c2csc([C@]3(C)CC(=O)N(C)C(=N)N3)c2)c1 CHEMBL2151141 Ki 7.8 nM
NC1=N[C@@]2(CO1)c1cc(-c3cncc(Cl)c3)ccc1OC1OC[C@H](OCC3CC3)C[C@@H]12 CHEMBL2152908 IC50 7.8 nM
COC1CCC2(CC1)Cc1ccc(-c3cccc(OC(F)(F)F)c3)cc1C21N=C(N)N(C)C1=O CHEMBL3656132 IC50 7.8 nM
COC1CCC2(CC1)Cc1ccc(-c3cccc(OC(F)(F)F)c3)cc1C21C=C(N)N(C)C1=O CHEMBL3974349 IC50 7.8 nM
CCN1C(=O)C2(N=C1N)c1cc(OCC3CC3)ccc1CC21CCC(OC)CC1 CHEMBL3941478 IC50 7.8 nM
COC1CCC2(CC1)Cc1ccc(CCC3CC3)cc1C21N=C(N)N(Cc2c[nH]cn2)C1=O CHEMBL3920748 IC50 7.8 nM
COc1ccc(C(=O)Nc2ccc3c(c2)C2(CCSC(N)=N2)c2cc(N4CCOCC4)cc(F)c2O3)nc1 CHEMBL3947150 IC50 7.8 nM
Cc1cc(C#N)cnc1C(=O)Nc1ccc(F)c([C@@]2(C(F)F)N=C(N)CCC2(F)F)c1 CHEMBL3893282 Ki 7.8 nM
CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)CNC(=O)c1[nH]c(=O)[nH]c(=O)c1F)C(C)C)C(=O)N[C@@H](Cc1ccccc1)[C@@H](O)C(=O)Nc1cccc(-c2noc(=O)[nH]2)c1 CHEMBL1094659 IC50 7.9 nM
COC1CCC2(CC1)Cc1ccc(-c3ccc(F)c(C#N)c3)cc1C21N=C(N)N(C)O1 CHEMBL3656133 IC50 7.9 nM
COC1CCC2(CC1)Cc1ccc(C#CC(C)(C)C)cc1C21N=C(N)N(C)C1=O CHEMBL3898481 IC50 7.9 nM
Cc1onc2c1CC1(CC2)Cc2ccc(-c3cccnc3)cc2C12N=C(N)N(C)C2=O CHEMBL3947174 IC50 7.9 nM
COc1cnc(C(=O)Nc2ccc(F)c([C@]3(C)CS(=O)(=O)C4(C[O+](C)C4)C(=N)N3)c2)cn1 CHEMBL4110849 Ki 7.9 nM
C[C@@]1(c2cc(NC(=O)c3ccc(C#N)cn3)ccc2F)C=COC(N)=N1 CHEMBL4205656 IC50 7.9 nM
NC1=N[C@](c2ccc(OC(F)F)cc2)(c2cccc(OCCCF)c2)C2=NCC(F)(F)CN12 CHEMBL1957483 pIC50 7.943 nM
NC1=N[C@](c2ccc(OC(F)F)cc2)(c2cccc(OCCF)c2)C2=NCC(F)(F)CN12 CHEMBL3261044 pIC50 7.943 nM
CC(C)C[C@H](NC(=O)C(CCS(C)(=O)=O)NC(=O)[C@@H](NC(=O)OC(C)(C)C)C(C)C)C(O)CC(C)C(=O)NC(C(=O)NCc1ccccc1)C(C)C CHEMBL440490 Ki 8.0 nM
CC(C)C[C@H](NC(=O)[C@H](CCS(C)(=O)=O)NC(=O)[C@@H](NC(=O)OC(C)(C)C)C(C)C)[C@@H](O)C[C@@H](C)C(=O)N[C@H](C(=O)NCc1ccccc1)C(C)C CHEMBL318115 Ki 8.0 nM
CC(C)C[C@H](NC(=O)C(CCS(C)(=O)=O)NC(=O)[C@@H](NC(=O)OC(C)(C)C)C(C)C)C(O)CC(C)C(=O)N[C@H](C(=O)NCc1ccccc1)C(C)C CHEMBL185777 Ki 8.0 nM
CC(C)CNC(=O)[C@H](C)NC[C@H](Cc1ccccc1)NC(=O)c1cc(C(=O)N[C@H](C)c2ccc(F)cc2)cc(N(C)S(C)(=O)=O)c1 CHEMBL379513 IC50 8.0 nM
CC(C)C[C@H](NC(=O)[C@H](CS(C)(=O)=O)NC(=O)[C@@H](NC(=O)OC(C)(C)C)C(C)C)[C@@H](O)C[C@@H](C)C(=O)N[C@H](C(=O)NCc1ccccc1)C(C)C CHEMBL95430 Ki 8.0 nM
CCNc1cc(C(=O)N[C@@H](Cc2ccccc2)[C@H](O)CNCc2cccc(OC)c2)cc(N2CCCCS2(=O)=O)c1 CHEMBL427719 IC50 8.0 nM
CCc1cn2c3c(cc(C(=O)N[C@@H](Cc4ccccc4)[C@H](O)CNCc4cccc(OC)c4)cc13)N(C)S(=O)(=O)C2 CHEMBL556747 IC50 8.0 nM
CCCNC[C@@H](O)[C@H](Cc1ccccc1)NC(=O)c1cc2c3c(cn(CC)c3c1)CCS(=O)(=O)N2C CHEMBL558273 IC50 8.0 nM
CCc1cn2c3c(cc(C(=O)N[C@@H](Cc4ccccc4)[C@H](O)CNCc4cccc(C(F)(F)F)c4)cc13)OS(=O)(=O)CC2 CHEMBL554146 IC50 8.0 nM
CCCN(CCC)C(=O)c1cc(C)cc(C(=O)N[C@@H](Cc2cc(F)cc(F)c2)[C@H](O)[C@H]2CN(S(=O)(=O)c3cccs3)CCN2)c1 CHEMBL1097333 Ki 8.0 nM
CC(C)[C@@H]1CCC(=O)N(C2CCCCC2)CCc2cccc(c2)Oc2ccc3c(c2)CN1C(N)=N3 CHEMBL1098082 Ki 8.0 nM
NC1=Nc2cc(F)c3cc2CN1[C@H](C1CCCCC1)CCC(=O)N(C1CCCCC1)CCc1cccc(c1)O3 CHEMBL1095429 Ki 8.0 nM
C[C@H](NC[C@@H](O)[C@H](Cc1ccccc1)NC(=O)c1cccc(N(c2cccc(C#N)c2)S(C)(=O)=O)c1)C(=O)NC1CCCCC1 CHEMBL1210344 IC50 8.0 nM
CN(C(=O)CC[C@@H](C1CCCCC1)N1Cc2cc(Oc3ccccc3)ccc2N=C1N)C1CCCCC1 CHEMBL244347 Ki 8.0 nM
CCCCn1cc(C2(c3cccc(-c4cncnc4)c3)N=C(N)N(C)C2=O)cn1 CHEMBL1824141 IC50 8.0 nM
CC(=O)N[C@]1(CC(C)C)CCN([C@@H](CCc2ccccc2)C(=O)N[C@@H](Cc2cc(F)cc(F)c2)[C@H](O)C2Cc3ccccc3CN2)C1=O CHEMBL1917905 IC50 8.0 nM
CC(=O)N[C@@H](Cc1ccc(F)cc1)[C@H](O)CN[C@H]1CC2(CC(F)(F)C2)Oc2ncc(CC(C)(C)C)cc21 CHEMBL2031146 IC50 8.0 nM
CCc1cc(C[C@@H]2CS(=O)(=O)C[C@H](NCc3cccc(C(C)(C)C)c3)[C@H]2O)cc(F)c1NC(C)=O CHEMBL2047905 IC50 8.0 nM
CC#Cc1cncc(-c2cc([C@]3(C)CC(=O)N(C)C(=N)N3)c(Cl)s2)c1 CHEMBL2151182 Ki 8.0 nM
CN1C(=N)N[C@@]2(c3cc(-c4cccc(C#N)c4)cs3)CN(c3ccccn3)C[C@H]2C1=O CHEMBL2178153 Ki 8.0 nM
CC(C)COc1ccc2c(c1)[C@]1(COC(N)=N1)c1cc(-c3cncnc3)ccc1O2 CHEMBL2177343 IC50 8.0 nM
CN1C(=O)[C@]2(CC(C)(C)Cc3ccc(-c4cccc(C#N)c4)cc32)N=C1N CHEMBL2349468 EC50 8.0 nM
CCCc1scc(-c2cn[nH]c2)c1CC(NC1=NC(C)(C)Cc2cc(Cl)ccc21)C(=O)O CHEMBL2380821 IC50 8.0 nM
CC(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)CN[C@H]1CC(C)(C)Oc2ccc(CC(C)(C)C)cc21 CHEMBL2408750 IC50 8.0 nM
CC(C)(C)c1cccc(CN[C@H]2C[S@+]([O-])C[C@@H](Cc3cc(F)c(N)c(OCC(F)(F)F)c3)[C@@H]2O)c1 CHEMBL2425611 IC50 8.0 nM
CC(C)(F)COc1ccc2c(c1)[C@]1(COC(N)=N1)c1cc(-c3cncnc3)ccc1O2 CHEMBL3354699 IC50 8.0 nM
Cc1noc(C)c1[C@@H]1C[C@@](C)(c2cc(-c3cncnc3)c(F)cc2F)N=C(N)S1 CHEMBL3427251 IC50 8.0 nM
C[C@]1(c2cc(NC(=O)c3ccc(OCC(F)(F)F)cn3)ccc2F)N=C(N)OC[C@@H]1F CHEMBL3680869 IC50 8.0 nM
Cc1cc(C(=O)Nc2ccc(F)c([C@@]3(C)N=C(N)OC[C@@H]3F)c2)c(C)o1 CHEMBL3680870 IC50 8.0 nM
C[C@]1(c2cc(NC(=O)c3cnc(OCC(F)F)cn3)ccc2F)N=C(N)OC[C@@H]1F CHEMBL3680871 IC50 8.0 nM
CC(C)(C)CCNC(=O)CCc1cc2cc(-c3ccccc3C#CCC3(NC(=O)c4ccc(F)cc4)CC3)ccc2nc1N CHEMBL3808441 Kd 8.0 nM
CCN1C(=O)C2(N=C1N)c1cc(CCC(C)C)ccc1C[C@]21CC[C@@H](OC)CC1 CHEMBL3656216 IC50 8.0 nM
C[C@@]1(c2cc(NC(=O)c3ncc(Cl)cc3N)ccc2F)CO[C@@](C)(C(F)(F)F)C(N)=N1 CHEMBL3653476 IC50 8.0 nM
NC1=N[C@@](c2cc(NC(=O)c3ncc(Br)cc3N)ccc2F)(C(F)F)COC1 CHEMBL3653488 IC50 8.0 nM
CC[C@@H]1C[C@]2(CC[C@H]1OC)Cc1ccc(C#N)cc1[C@]21N=C(N)N(CC2CCOCC2)C1=O CHEMBL4107226 IC50 8.0 nM
CC[C@H]1C[C@@]2(CC[C@@H]1OC)Cc1ccc(C#N)cc1[C@]21N=C(N)N(C[C@H]2CCCO2)C1=O CHEMBL3964240 IC50 8.0 nM
CO[C@H]1[C@H](C)C[C@@]2(Cc3ccc(C#N)cc3[C@]23N=C(N)N(C[C@H]2COCCO2)C3=O)C[C@@H]1C CHEMBL3980437 IC50 8.0 nM
C[C@@]1(c2cc(NC(=O)c3ccc(Cl)cn3)ccc2F)CS(=O)(=O)C2(CCC2)C(=N)N1 CHEMBL3967867 Ki 8.0 nM
CN1C(=O)C2(N=C1N)c1cc(OCC(F)(F)F)ccc1C[C@]21CC[C@@H](OC(F)F)CC1 CHEMBL3946221 IC50 8.0 nM
COc1cnc(C(=O)Nc2ccc3c(c2)C2(COC(N)=N2)C2(COC2)C(C)(C)O3)cn1 CHEMBL3650852 IC50 8.0 nM
Cc1cc(Cl)cnc1C(=O)Nc1ccc(F)c([C@]2(CF)C[C@@H](C(F)(F)F)OC(N)=N2)c1 CHEMBL3920732 IC50 8.0 nM
C[C@@]1(c2cc(NC(=O)c3cnc(OCC(F)(F)F)cn3)cc(Cl)c2F)C[C@@H](C(F)(F)F)OC(N)=N1 CHEMBL3891152 IC50 8.0 nM
CC1(C)C(=N)N[C@@]2(c3cc(NC(=O)c4cnsn4)ccc3F)COC[C@H]2S1(=O)=O CHEMBL4109231 Ki 8.0 nM
CCN=S1(=O)C[C@@](C)(c2cc(NC(=O)c3ccc(Cl)cn3)ccc2F)NC(=N)N1C CHEMBL3891223 Ki 8.0 nM
COc1cnc(C(=S)Nc2cc(F)c(F)c([C@]3(C)CS(=O)(=O)N(C)C(=N)N3)c2)cn1 CHEMBL3895521 Ki 8.0 nM
CCNCc1cc([C@]2(C)CCSC(N)=N2)c(F)cc1F CHEMBL4061944 IC50 8.0 nM
NC1=NC(c2cc(NC(=O)c3ccc(Br)cn3)ccc2F)(C(F)F)COC1 CHEMBL3653377 IC50 8.0 nM
C[C@@]1(c2cc(NC(=O)c3ncc(Cl)cc3Cl)ccc2F)CO[C@@](C)(C(F)(F)F)C(N)=N1 CHEMBL5085959 IC50 8.0 nM
C[C@@]1(c2cc(NC(=O)c3ccc(Cl)cn3)ccc2F)CS(=O)(=O)[C@]2(CCOC2)C(=N)N1 CHEMBL3913185 Ki 8.1 nM
CCN1C(=O)C2(N=C1N)c1cc(-c3cccc(Cl)c3)ccc1CC21CCC(OC)CC1 CHEMBL3914405 IC50 8.1 nM
COCCN1C(=O)C2(N=C1N)c1cc(-c3cncc(F)c3)ccc1CC21CCc2ccccc2CC1 CHEMBL3969469 IC50 8.1 nM
Cc1nnc(-c2ccc(-c3cc(Cl)c([C@]4(C)CS(=O)(=O)N(C)C(=N)N4)s3)[nH]2)o1 CHEMBL3904722 Ki 8.1 nM
CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)CNC(=O)c1nn[nH]n1)C(C)C)C(=O)N[C@@H](Cc1ccccc1)[C@@H](O)C(=O)Nc1cccc(C(=O)O)c1 CHEMBL183494 IC50 8.2 nM
CC#Cc1cncc(-c2ccc3c(c2)[C@@]2(N=C(C)C(N)=N2)[C@@]2(C3)C[C@@H](C)[C@H](OC)[C@@H](C)C2)c1 CHEMBL3927865 IC50 8.2 nM
NC1=N[C@](c2ccncc2)(c2cccc(-c3cncnc3)c2)c2cccc(F)c21 CHEMBL2177904 IC50 8.25 nM
CC(=O)N[C@@H](Cc1ccc(Cl)cc1)[C@H](O)CN[C@H]1CC2(CCC2)Oc2ncc(CC(C)(C)C)cc21 CHEMBL2151153 IC50 8.3 nM
COc1cncc(-c2ccc3c(c2)[C@]2(N=C(N)N(C)C2=O)[C@H]2COCC[C@@H]2O3)c1 CHEMBL3127088 IC50 8.3 nM
C[C@@]1(c2cc(NC(=O)c3ccc(Cl)cn3)ccc2F)CS(=O)(=O)C2(CCCCC2)C(=N)N1 CHEMBL3261079 IC50 8.4 nM
CN1OC2(N=C1N)c1cc(C#CC3CC3)ccc1CC21CCc2ccccc2CC1 CHEMBL3928355 IC50 8.4 nM
CN1C(=O)C2(N=C1N)c1cc(C#CC3CC3)ccc1CC21CCC(OC(F)F)CC1 CHEMBL3973849 IC50 8.4 nM
Cc1noc2c1CC1(CC2)Cc2ccc(-c3cccc(C#N)c3)cc2C12N=C(N)N(C)O2 CHEMBL3956888 IC50 8.4 nM
C#CCOc1cnc(C(=O)Nc2ccc(F)c([C@]3(C)C[C@@H](C(F)(F)F)OC(N)=N3)n2)cn1 CHEMBL3908288 IC50 8.4 nM
Cc1cc(C#N)cnc1C(=O)Nc1ccc(F)c([C@]2(C)C=C(CF)OC(N)=N2)c1 CHEMBL4204742 IC50 8.4 nM
CC(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNC1CC(C)(C)Oc2sc(CC(C)(C)C)cc21 CHEMBL2158253 IC50 8.5 nM
C#C[C@H](C)Oc1cnc(C(=O)Nc2ccc(F)c([C@@]3(C(F)F)N=C(N)O[C@@H]4C[C@@H]43)c2)cn1 CHEMBL3683908 IC50 8.5 nM
COc1cnc(C(=O)Nc2ccc(F)c([C@@]3(C(F)F)N=C(N)CCC3(F)F)c2)cn1 CHEMBL3961890 Ki 8.5 nM
CC(=O)N[C@]1(CC(C)C)CCN([C@@H](CCc2ccccc2)C(=O)N[C@@H](Cc2cc(F)cc(F)c2)[C@H](O)[C@H]2Cc3ccccc3CN2)C1=O CHEMBL1915985 IC50 8.6 nM
NC1=N[C@@](c2cccc(-c3cncnc3)c2)(c2ccnc(C(F)F)c2)c2cc(F)cc(F)c21 CHEMBL2177914 IC50 8.64 nM
C[C@H]1C[C@@]2(CC[C@@H]1O)Cc1ccc(C#N)cc1[C@]21N=C(N)N(CC2CC(F)(F)C2)C1=O CHEMBL3953596 IC50 8.7 nM
CN1C(=O)C2(N=C1N)c1cc(-c3cccnc3)ccc1OC21CCc2ccccc2CC1 CHEMBL3925501 IC50 8.7 nM
CN1C(=N)N[C@](C)(c2sc(-c3cccc(-c4ncco4)c3)cc2F)CS1(=O)=O CHEMBL3949563 Ki 8.7 nM
CC(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)CN[C@@]1(c2cccc(C(C)(C)C)c2)CC/C(=N/O)NC1 CHEMBL566603 IC50 8.8 nM
COC1CCC2(CC1)Cc1ccc(-c3ccc(F)c(Cl)c3)cc1C21N=C(N)N(C)O1 CHEMBL3656134 IC50 8.8 nM
COC1CCC2(CC1)Cc1ccc(CCC3CC3)cc1C21N=C(N)N(Cc2cscn2)C1=O CHEMBL3909268 IC50 8.8 nM
NC1=NC2(CCO1)c1cc(NC(=O)c3ccc(F)cn3)ccc1Oc1c(F)cc(-c3ccnc(F)c3)cc12 CHEMBL3937992 IC50 8.8 nM
CN1C(=N)N[C@](C)(c2cc(-c3cc(F)cc(-c4nnco4)c3)cs2)CS1(=O)=O CHEMBL3937537 Ki 8.8 nM
CCC(C)[C@@]1(NC(C)=O)CCN([C@@H](CCc2ccccc2)C(=O)N[C@@H](Cc2cc(F)cc(F)c2)[C@H](O)[C@H]2C[C@@H](OCc3ccc(F)cc3)CN2)C1=O CHEMBL1916168 IC50 8.9 nM
NC1=N[C@]2(CO1)c1cc(-c3cncc(Cl)c3)ccc1OC1OC[C@H](OCC3CC3)C[C@@H]12 CHEMBL2152909 IC50 8.9 nM
CN1C(=O)[C@]2(CC(C)(C)Cc3ccc(-c4cccnc4F)cc32)N=C1N CHEMBL2349469 EC50 8.9 nM
COc1nc(N2C[C@H]3C(=O)N(C)C(=N)N[C@@]3(c3cc(F)ccc3Cl)C2)nc(C)c1F CHEMBL3640291 Ki 8.9 nM
CC#CCOc1ccc(C(=O)Nc2ccc(F)c([C@@]3(CF)N=C(N)O[C@@H]4C[C@@H]43)c2)nc1 CHEMBL3688634 IC50 8.9 nM
COC1CCC2(CC1)Cc1ccc(-c3cncc(Cl)c3)cc1C21N=C(N)N(C(C)C)C1=O CHEMBL3911980 IC50 8.9 nM
COC1CCC2(CC1)Cc1ccc(-c3cncc(F)c3)cc1C21N=C(N)N(C(C)C)C1=O CHEMBL3976065 IC50 8.9 nM
COC1CCC2(CC1)Cc1ccc(OCC3CCCC3)cc1C21N=C(N)N(C)C1=O CHEMBL3914214 IC50 8.9 nM
CCCSc1ccc2c(c1)C1(N=C(N)N(CCOC)C1=O)C1(CCC(OC)CC1)C2 CHEMBL3952033 IC50 8.9 nM
CC1OB(c2ccc(F)c([C@]3(CF)C[C@@H](C(F)(F)F)OC(NC(=O)c4ccccc4)=N3)c2)OC1(C)C CHEMBL3960028 IC50 8.9 nM
NC1=N[C@](CF)(c2cc(NC(=O)c3cnc(OCF)cn3)ccc2F)CCC1(F)F CHEMBL4643511 IC50 8.9 nM
NC1=N[C@](CF)(c2cc(-c3cnc(OCF)cn3)ccc2F)CCC1(F)F CHEMBL5192629 IC50 8.9 nM
C[C@@H](NC(=O)c1cc(C(=O)N[C@@H](Cc2ccccc2)[C@H](O)CNC2CC2)cc(N(C)S(=O)(=O)N(C)C)c1)c1ccccc1 CHEMBL376277 IC50 9.0 nM
C[C@@H](NC(=O)c1cc(-c2nnc([C@](C)(N)Cc3ccccc3)o2)cc(N(C)S(C)(=O)=O)c1)c1ccc(F)cc1 CHEMBL219601 IC50 9.0 nM
CCCC[C@H](N)[C@H](Cc1cc(F)cc(F)c1)NC(=O)c1cc(NCC2CC2C)nc(N(C)S(C)(=O)=O)c1 CHEMBL247043 IC50 9.0 nM
CC(C)(C)c1cccc(CNC[C@@H](O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CN(Cc3cc(F)cc(F)c3)C(=O)N2)c1 CHEMBL260834 Ki 9.0 nM
CCNc1cc(C(=O)N[C@@H](Cc2ccccc2)[C@H](O)CNCc2cccc(C(F)(F)F)c2)c(F)c(N2CCCC2=O)c1 CHEMBL445734 IC50 9.0 nM
CCCN1CC(C(=O)N[C@@H](Cc2cc(F)cc(F)c2)[C@H](O)[C@@H]2NCCN(Cc3ccccc3)C2=O)N(CC)C1=O CHEMBL491660 IC50 9.0 nM
CCCN1CC(C(=O)N[C@@H](Cc2cc(F)cc(F)c2)[C@H](O)[C@@H]2NCCN(Cc3ccccc3)C2=O)CC1=O CHEMBL490463 IC50 9.0 nM
CCc1cn2c3c(cc(C(=O)N[C@@H](Cc4ccccc4)[C@H](O)CNC(C)(C)CCCC(C)C)cc13)N(C)S(=O)(=O)CC2 CHEMBL500275 IC50 9.0 nM
O=C(N[C@@H](Cc1ccccc1)[C@H](O)C(=O)Nc1cccc(-c2nn[nH]n2)c1)c1cc(Br)cc(C(=O)N2COC[C@@H]2c2ccc(F)cc2)n1 CHEMBL453211 IC50 9.0 nM
CCc1cn2c3c(cc(C(=O)N[C@@H](Cc4ccccc4)[C@H](O)CNC4CCCCC4)cc13)N(C)S(=O)(=O)CC2 CHEMBL561961 IC50 9.0 nM
CCn1cc2c3c(cc(C(=O)N[C@@H](Cc4ccccc4)[C@H](O)CNC4CC4)cc31)N(C)S(=O)(=O)CC2 CHEMBL550208 IC50 9.0 nM
CCc1cn2c3c(cc(C(=O)N[C@@H](Cc4ccccc4)[C@H](O)CNC4CCOCC4)cc13)N(C)S(=O)(=O)CC2 CHEMBL560612 IC50 9.0 nM
COc1cccc(CNC[C@@H](O)[C@H](Cc2cc(F)cc(F)c2)NC(=O)c2cc(/C(C)=N\OCc3ccccc3)cc(N(C)S(C)(=O)=O)c2)c1 CHEMBL550271 IC50 9.0 nM
COc1cccc(CNC[C@@H](O)[C@H](Cc2cc(F)cc(F)c2)NC(=O)c2cc(/C(C)=N\O)cc(N(c3ccccc3)S(C)(=O)=O)c2)c1 CHEMBL553458 IC50 9.0 nM
COCc1cc2cc(n1)OCCCCOc1cccc(c1)C[C@@H]([C@H](O)CNC1(c3cccc(C(C)C)c3)CC1)NC2=O CHEMBL595267 IC50 9.0 nM
CO[C@H](C[C@H](O)[C@H](COc1ccccc1)NC(=O)c1cc(C(=O)N[C@H](C)c2ccccc2)cc(N(C)CS(C)(=O)=O)c1)C(=O)N[C@H](C(=O)NCc1ccccc1)C(C)C CHEMBL603119 Ki 9.0 nM
CC(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)CNC1(c2cc(F)cc(C(C)(C)C)c2)CCCCC1 CHEMBL1257531 ED50 9.0 nM
CC(=O)N[C@@H](Cc1ccc(F)cc1)[C@H](O)CN[C@H]1C[C@]2(C[C@@H](C)C2)Oc2ncc(CC(C)(C)C)cc21 CHEMBL2031140 IC50 9.0 nM
CC(=O)N[C@@H](Cc1ccc(F)cc1)[C@H](O)CN[C@H]1C[C@]2(C[C@@H](F)C2)Oc2ncc(CC(C)(C)C)cc21 CHEMBL2031144 IC50 9.0 nM
Cc1cnc(N2C[C@H]3C(=O)N(C)C(=N)N[C@@]3(c3cc(-c4cccc(C#N)c4)cs3)C2)nc1 CHEMBL2178143 Ki 9.0 nM
CN1C(=O)C2(CC(C)(C)Cc3ccc(-c4cncc(Cl)c4)cc32)N=C1N CHEMBL2349478 EC50 9.0 nM
N#Cc1ccc(C(=O)Nc2ccc(F)c([C@]3(C(F)F)CCOC(N)=N3)c2)nc1 CHEMBL2347206 IC50 9.0 nM
CC(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)CN[C@H]1CC(C)(C)Oc2ccc(CC(C)(F)F)cc21 CHEMBL2408756 IC50 9.0 nM
COC[C@@]1(C)C[C@H](NC[C@@H](O)[C@H](Cc2cc(F)cc(F)c2)NC(C)=O)c2cc(CC(C)(C)C)ccc2O1 CHEMBL2408753 IC50 9.0 nM
CC(C)(C#N)COc1ccc2c(c1)[C@]1(COC(N)=N1)c1cc(-c3cncnc3)ccc1O2 CHEMBL3354700 IC50 9.0 nM
CC(C)(F)COc1cc(F)c2c(c1)[C@]1(COC(N)=N1)c1cc(-c3cccnc3F)ccc1O2 CHEMBL3354716 IC50 9.0 nM
COc1cnc(-c2cc(-c3ccc(F)c([C@]4(C)C[S@@]5(=O)=NCCCCN5C(N)=N4)c3)on2)cn1 CHEMBL3741614 IC50 9.0 nM
CO[C@H]1CC[C@]2(CC1)Cc1ccc(CCC(C)C)cc1C21N=C(N)N(CC(F)F)C1=O CHEMBL3934938 IC50 9.0 nM
COCCN1C(=O)C2(N=C1N)c1cc(CCC(C)C)ccc1C[C@]21CC[C@@H](OC)CC1 CHEMBL3656215 IC50 9.0 nM
COc1ccc(C(=O)Nc2ccc(F)c([C@]3(C)CO[C@@](C)(C(F)(F)F)C(N)=N3)c2)nc1 CHEMBL3653402 IC50 9.0 nM
Cc1c(C(=O)Nc2ccc(F)c([C@]3(C(F)F)COCC(N)=N3)c2)oc2ccc(CN(C)C)cc12 CHEMBL3653495 IC50 9.0 nM
COc1cc(F)c2c(c1)C1(N=C(N)n3ccnc31)c1cc(-c3cccnc3F)ccc1O2 CHEMBL3677269 IC50 9.0 nM
CO[C@H]1CC[C@@]2(Cc3ccc(C#N)cc3[C@]23N=C(N)N(Cc2ccncn2)C3=O)C[C@@H]1C CHEMBL3892262 IC50 9.0 nM
CO[C@H]1[C@H](C)C[C@@]2(Cc3ccc(C#N)cc3[C@]23N=C(N)N(Cc2ncc(F)cn2)C3=O)C[C@@H]1C CHEMBL4109974 IC50 9.0 nM
CO[C@H]1[C@H](C)C[C@@]2(Cc3ccc(C#N)cc3[C@]23N=C(N)N(CC2COC2)C3=O)C[C@@H]1C CHEMBL4108797 IC50 9.0 nM
CO[C@H]1[C@H](C)C[C@@]2(Cc3ccc(C#N)cc3[C@]23N=C(N)N(C[C@@H]2CCO2)C3=O)C[C@@H]1C CHEMBL3967706 IC50 9.0 nM
CC[C@@H]1C[C@@]2(Cc3ccc(C#N)cc3[C@]23N=C(N)N(CC(C)(C)F)C3=O)C[C@H](C)[C@H]1OC CHEMBL3957841 IC50 9.0 nM
COC1CCC2(CC1)Cc1ccc(OCC(F)(F)F)cc1C21CN(C)C(N)=N1 CHEMBL3915398 IC50 9.0 nM
COC1CCC2(CC1)Cc1ccc(OCC3CC3)cc1C21NC(N)N(CC(F)F)C1=O CHEMBL3975061 IC50 9.0 nM
NC1=N[C@@]2(c3cc(NC(=O)c4ccc(OC(F)F)cn4)ccc3F)COCC[C@H]2CS1 CHEMBL3973534 IC50 9.0 nM
C[C@@H]1OC[C@]2(c3cc(NC(=O)c4ccc(F)cn4)ccc3F)NC(=N)C(C)(C)S(=O)(=O)[C@H]12 CHEMBL3974476 Ki 9.0 nM
CN1C(=N)N[C@](C)(c2cc(NC(=S)c3ccc(Cl)cn3)cc(F)c2F)CS1(=O)=O CHEMBL3932463 Ki 9.0 nM
Cc1cc(C#N)cnc1C(=O)Nc1cc(F)c(F)c([C@]2(C(F)F)COCC(N)=N2)c1 CHEMBL4128770 IC50 9.0 nM
CC#CCOc1cnc(C2=Nc3cc([C@]4(C)C[C@@H](C(F)(F)F)OC(N)=N4)c(F)cc3CN2)cn1 CHEMBL4453767 IC50 9.0 nM
CCn1cc(C2(c3cccc(-c4cncnc4)c3)N=C(N)c3c(F)cccc32)cc(C)c1=O CHEMBL2177920 IC50 9.09 nM
COC(OC)C(=O)N[C@@H](Cc1cccc(-c2nccs2)c1)[C@H](O)CN[C@H]1CC2(CCC2)Oc2ncc(CC(C)(C)C)cc21 CHEMBL2181914 IC50 9.1 nM
C[C@@]1(c2cccc(NC(=O)c3ccc(Cl)cn3)c2)COCC(N)=N1 CHEMBL3634122 IC50 9.1 nM
COc1cnc(C(=O)Nc2ccc(F)c([C@@]3(C)N=C(N)CO[C@@H]3F)c2)cn1 CHEMBL3634125 IC50 9.1 nM
CN1C(=N)N[C@](C)(c2cc(NC(=S)c3ccc(Cl)cn3)ccc2F)CS1(=O)=O CHEMBL3986336 Ki 9.1 nM
CN1C(N)=N[C@](C)(c2cc(NC(=S)c3ccc(C#N)cn3)ccc2F)CS1(=O)=O CHEMBL4458706 Ki 9.1 nM
C[C@@]1(c2cc(NC(=O)c3ccc(C#N)cn3)ccc2F)Cn2nnnc2C(N)=N1 CHEMBL4446937 pIC50 9.12 nM
COc1nc(N2C[C@H]3C(=O)N(C)C(N)=N[C@@]3(c3ccc(F)c(Cl)c3F)C2)nc(C)c1F CHEMBL3640285 Ki 9.2 nM
COCCN1C(=O)C2(N=C1N)c1cc(C#CC3CC3)ccc1CC21CCC(OC)CC1 CHEMBL3942229 IC50 9.2 nM
CC#Cc1cncc(-c2ccc3c(c2)C2(COC(N)=N2)C2(COC2)C(C)(C)O3)c1 CHEMBL3703303 IC50 9.2 nM
COc1ccc(C[C@H](NC(C)=O)[C@H](O)CN[C@H]2CC3(CCC3)Oc3ncc(CC(C)(C)C)cc32)cc1OC CHEMBL2181885 IC50 9.3 nM
COCC(=O)N[C@@H](Cc1cccc(-c2ccccn2)c1)[C@H](O)CN[C@H]1CC2(CCC2)Oc2ncc(CC(C)(C)C)cc21 CHEMBL2181889 IC50 9.3 nM
COc1nc(N2C[C@H]3C(=O)N(C)C(N)=N[C@@]3(c3ccccc3F)C2)nc(C)c1Cl CHEMBL3640264 Ki 9.3 nM
CN1C(=O)C[C@]2(N=C1N)c1cc(-c3cccnc3F)ccc1Oc1cnc(C3=CCOCC3)cc12 CHEMBL3695738 IC50 9.3 nM
NC1=N[C@@](c2cc(NC(=O)c3ccc(Br)cn3)ccc2Cl)(C(F)F)[C@H]2C[C@H]2O1 CHEMBL3688645 IC50 9.3 nM
C[C@@]1(c2cc(NC(=O)c3ccc(F)cn3)ccc2F)CS(=O)(=O)C2(CCC(O)C2)C(=N)N1 CHEMBL3965337 Ki 9.3 nM
COC1CCC2(CC1)Cc1ccc(C#CC3CC3)cc1C21NC(N)N(CCN(C)S(C)(=O)=O)C1=O CHEMBL3931613 IC50 9.3 nM
C#CCOc1ccc(C(=O)Nc2ccc(F)c([C@]3(C)C[C@@H](C(F)(F)F)OC(N)=N3)c2)nc1 CHEMBL3912808 IC50 9.3 nM
NC1=NC2(CCO1)c1cc(NC(=O)c3ccc(F)cn3)ccc1Oc1c2cc(C2=CCCOC2)nc1F CHEMBL3930557 IC50 9.3 nM
CC(C)C[C@H](NC(=O)C(CS(C)(=O)=O)NC(=O)[C@@H](NC(=O)OC(C)(C)C)C(C)C)C(O)CC(C)C(=O)NC(C(=O)NCc1ccccc1)C(C)C CHEMBL294274 Ki 9.4 nM
CC(C)C[C@H](NC(=O)C(CS(C)(=O)=O)NC(=O)[C@@H](NC(=O)OC(C)(C)C)C(C)C)C(O)CC(C)C(=O)N[C@H](C(=O)NCc1ccccc1)C(C)C CHEMBL264004 Ki 9.4 nM
CO[C@H]1CC[C@]2(CC1)Cc1ccc(C#CC3CC3)cc1C21N=C(N)N(Cc2nnc(C)s2)C1=O CHEMBL3925344 IC50 9.4 nM
Cc1cc(CN2C(=O)[C@]3(N=C2N)c2cc(C#N)ccc2C[C@@]32C[C@@H](C)[C@H](O)[C@@H](C)C2)ccn1 CHEMBL4111730 IC50 9.4 nM
C#CCOc1cnc(C(=O)Nc2cnc(F)c([C@@]3(CF)N=C(N)O[C@@H]4C[C@@H]43)c2)cn1 CHEMBL3688637 IC50 9.4 nM
CC1(C)Oc2ccc(NC(=O)c3ccc(Cl)cn3)cc2C2(COC(N)=N2)C12COC2 CHEMBL3703232 IC50 9.4 nM
COc1cnc(C(=O)Nc2ccc3c(c2)[C@@]2(CCOC(N)=N2)c2cc(C4=CCCOC4)ncc2O3)cn1 CHEMBL3959153 IC50 9.4 nM
COc1cnc(C(=O)Nc2ccc3c(c2)C2(CCOC(N)=N2)c2cc(C4=CCCOC4)ncc2O3)cn1 CHEMBL3981595 IC50 9.4 nM
C[C@@]1(c2cc(NC(=O)c3ccc(F)cn3)ccc2F)Cc2ncncc2C(N)=N1 CHEMBL4439298 Ki 9.4 nM
COCC(=O)N[C@@H](Cc1cc(-c2nccs2)ccc1F)[C@H](O)CN[C@H]1CC2(CCC2)Oc2ncc(CC(C)(C)C)cc21 CHEMBL2181903 IC50 9.5 nM
CC[C@H](NC[C@H](Cc1ccccc1)NC(=O)c1cc(C(=O)N[C@H](C)c2ccccc2)cc(N(C)S(C)(=O)=O)c1)C(=O)NCC(C)C CHEMBL2179130 IC50 9.5 nM
C[C@@]1(c2cc(-c3cc(-c4ncc(Cl)cn4)no3)ccc2F)C[S@]2(=O)=NCCCCN2C(N)=N1 CHEMBL3741282 IC50 9.5 nM
C[C@@]1(c2cc(-c3cn(-c4ccc(C#N)cn4)nn3)ccc2F)C[S@]2(=O)=NCCCCN2C(N)=N1 CHEMBL3741314 IC50 9.5 nM
COC1CCC2(CC1)Cc1ccc(-c3cc(F)cc(Cl)c3)cc1C21N=C(N)N2CCCN=C21 CHEMBL3673209 IC50 9.5 nM
COC1CCC2(CC1)Cc1ccc(-c3cnc(C)s3)cc1C21N=C(N)N(C)C1=O CHEMBL3907602 IC50 9.5 nM
Cc1cc(Cl)cnc1C(=O)Nc1cc(F)c(F)c([C@]2(C)C[C@@H](C(F)(F)F)OC(N)=N2)c1 CHEMBL3925742 IC50 9.5 nM
COc1cc(C(=O)Nc2ccc(F)c([C@]3(CF)CC[C@@](C)(S(C)(=O)=O)C(N)=N3)c2)ncn1 CHEMBL5082356 IC50 9.5 nM
CC(C)C[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)C(C)C)[C@@H](O)C[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)O CHEMBL509188 Ki 9.6 nM
COCC(=O)N[C@@H](Cc1cccc(-c2ncco2)c1)[C@H](O)CN[C@H]1CC2(CCC2)Oc2ncc(CC(C)(C)C)cc21 CHEMBL2181890 IC50 9.6 nM
COC1CCC2(CC1)Cc1ccc(OC(F)(F)C(F)F)cc1C21N=C(N)N(C)C1=O CHEMBL3952868 IC50 9.6 nM
COc1ncc(C(=O)NC2CC2)c2c1C[C@]1(c3ccc(F)cc3F)N=C(N)SC[C@@H]1C2 CHEMBL4459963 IC50 9.6 nM
C[C@@H]1C[C@@]2(Cc3ccc(C#N)cc3[C@]23N=C(N)N(CCc2ccncc2)C3=O)C[C@H](C)[C@H]1O CHEMBL4111013 IC50 9.7 nM
COC1CCC2(CC1)Cc1ccc(C#CC3CCCC3)cc1C21N=C(N)N(C)O1 CHEMBL3908165 IC50 9.7 nM
COC1CCC2(CC1)Cc1ccc(CCC3CC3)cc1C21N=C(N)N(CC2CCN(C(C)=O)CC2)C1=O CHEMBL3923089 IC50 9.7 nM
CN1C(=O)[C@]2(N=C1N)c1cc(OCC3CC3)ccc1CC21CCc2ccccc2CC1 CHEMBL4113098 IC50 9.7 nM
CN1C(=N)N[C@@]2(c3cc(NC(=O)c4ccc(C(F)(F)F)cn4)ccc3F)COC[C@H]2S1(=O)=O CHEMBL4113989 Ki 9.79 nM
COCC(=O)N[C@@H](Cc1cccc(-c2ccncc2)c1)[C@H](O)CN[C@H]1CC2(CCC2)Oc2ncc(CC(C)(C)C)cc21 CHEMBL2181888 IC50 9.8 nM
NC1=N[C@@](c2cc(NC(=O)c3nn(C(F)F)cc3Cl)cc(F)c2F)(C(F)F)[C@H]2C[C@H]2O1 CHEMBL3683867 IC50 9.8 nM
COc1cnc(C(=O)Nc2cc(F)c(F)c([C@]3(C)C[C@@H](C(F)(F)F)OC(N)=N3)c2)cn1 CHEMBL3915646 IC50 9.8 nM
COc1cnc(-c2ccc(F)c([C@]3(C)CC[C@@](C)(C#N)C(N)=N3)c2)cn1 CHEMBL5170536 IC50 9.8 nM
C#Cc1ccc2c(c1)C1(N=C(N)N(C)C1=O)C1(CCC(OC)CC1)C2 CHEMBL3956746 IC50 9.9 nM