CCCC(O)C(NCC(O)C(Cc1ccccc1)NC(=O)c1cc(C)cc(C(=O)N(C)C(C)c2ccccc2)c1)C(=O)NCC(C)C CHEMBL3704768 Ki 0.0014 nM
CCCC(O)C(NCC(O)C(Cc1ccccc1)NC(=O)c1cccc(C(=O)N(C)C(C)c2ccccc2)c1)C(=O)NCC(C)C CHEMBL3664019 Ki 0.02 nM
C[C@H]1SC(N)=N[C@](C)(c2cc(NC(=O)c3cnc(OCF)cn3)ccc2F)[C@H]1F CHEMBL4557670 Ki 0.12 nM
C[C@@]1(c2cc(NC(=O)c3cnc(OCF)cn3)ccc2F)C[C@@H](C(F)F)SC(N)=N1 CHEMBL4438526 IC50 0.19 nM
CN1C(=N)N[C@](C)(c2cc(NC(=O)c3ccc(Cl)cn3)ccc2F)CS1(=O)=O CHEMBL3672916 Ki 0.22 nM
CN1C(=N)N[C@](C)(c2sc(-c3cccc(-c4noc(C5CC5)n4)c3)cc2Cl)CS1(=O)=O CHEMBL3952769 Ki 0.24 nM
CN1C(=N)N[C@](C)(c2sc(-c3cc(F)cc(-c4nnco4)c3)cc2Cl)CS1(=O)=O CHEMBL3942915 Ki 0.28 nM
Cc1nc(C(=O)Nc2ccc(F)c([C@]3(C)Cn4nc(C#N)cc4C(N)=N3)c2)co1 CHEMBL5093195 Ki 0.29 nM
C[C@@]1(c2cc(NC(=O)c3ccc(Cl)cn3)ccc2F)CS(=O)(=O)C2(CCCC2)C(=N)N1 CHEMBL3938241 Ki 0.3 nM
C[C@@]1(c2cc(NC(=O)c3ccc(F)cn3)ccc2F)CS(=O)(=O)C2(CCCC2)C(=N)N1 CHEMBL3936864 Ki 0.3 nM
CN1C(=N)N[C@](C)(c2sc(-c3cncc(-c4ncco4)c3)cc2Cl)CS1(=O)=O CHEMBL3962846 Ki 0.31 nM
COc1ccc(C(=O)Nc2ccc(F)c([C@]3(C)CS(=O)(=O)C4(CN(c5ccc([N+](=O)[O-])cc5)C4)C(=N)N3)c2)nc1 CHEMBL3917788 Ki 0.32 nM
CN1C(=N)N[C@](C)(c2sc(-c3cccc(-c4ncon4)c3)cc2F)CS1(=O)=O CHEMBL3908329 Ki 0.34 nM
CN1C(=N)N[C@](C)(c2sc(-c3cccc(-c4cc[nH]n4)c3)cc2F)CS1(=O)=O CHEMBL3933178 Ki 0.35 nM
Cc1nc(-c2cccc(-c3cc(Cl)c([C@]4(C)CS(=O)(=O)N(C)C(=N)N4)s3)c2)no1 CHEMBL3892420 Ki 0.35 nM
CN1C(N)=N[C@](C)(c2cc(NC(=O)c3ccc(F)cn3)ccc2F)CS1(=O)=O CHEMBL3301601 Ki 0.37 nM
CC#Cc1cncc(-c2cc(Cl)c([C@]3(C)CS(=O)(=O)N(C)C(=N)N3)s2)c1 CHEMBL3259832 Ki 0.37 nM
NC1=N[C@@]2(c3cc(NC(=O)c4ccc(F)cn4)ccc3F)CN(c3ncc(F)cn3)C[C@H]2CS1 CHEMBL3667410 IC50 0.388 nM
C[C@@]1(c2cc(NC(=O)c3ccc(Cl)cn3)ccc2F)CS(=O)(=O)C2(CC2)C(=N)N1 CHEMBL3973607 Ki 0.4 nM
CN1CC2(C1)C(=N)N[C@](C)(c1cc(NC(=O)c3ccc(Cl)cn3)ccc1F)CS2(=O)=O CHEMBL3903468 Ki 0.4 nM
CN1C(=N)N[C@](C)(c2sc(-c3cccc(-c4ncon4)c3)cc2Cl)CS1(=O)=O CHEMBL3939857 Ki 0.41 nM
Cc1ccc(C(=O)Nc2ccc(F)c([C@]3(C)CS(=O)(=O)N(C)C(=N)N3)c2)nc1 CHEMBL3672920 Ki 0.45 nM
CN1C(=N)N[C@](C)(c2c(F)ccc(NC(=O)c3ccc(F)cn3)c2F)CS1(=O)=O CHEMBL3702860 Ki 0.47 nM
C[C@@]1(c2cc(NC(=O)c3ncc(F)cc3F)ccc2F)CS(=O)(=O)C2(CC2)C(=N)N1 CHEMBL3973232 Ki 0.5 nM
CN1CC2(C1)C(=N)N[C@](C)(c1cc(NC(=O)c3ncc(C#N)cc3C(F)F)ccc1F)CS2(=O)=O CHEMBL3925463 Ki 0.5 nM
CN1C(=N)N[C@@]2(c3cc(NC(=O)c4nccc5cc(Br)cnc45)ccc3F)CCC[C@H]2S1(=O)=O CHEMBL4128375 Ki 0.5 nM
CC(F)(F)[C@@H]1C[C@@](C)(c2cc(NC(=O)c3ccc(OCF)cn3)ccc2F)N=C(N)S1 CHEMBL4475802 IC50 0.5 nM
NC1=N[C@@]2(c3cc(NC(=O)c4ncc(F)cc4F)ccc3F)CN(c3ncc(F)cn3)C[C@H]2CS1 CHEMBL3667415 IC50 0.555 nM
COc1ccc(C(=O)Nc2ccc(F)c([C@]3(C)CS(=O)(=O)C4(CCCC4)C(=N)N3)c2)nc1 CHEMBL3942552 Ki 0.6 nM
COc1ccc(C(=O)Nc2ccc(F)c([C@]3(C)CS(=O)(=O)C4(CN(Cc5ccccc5)C4)C(=N)N3)c2)nc1 CHEMBL3905233 Ki 0.6 nM
CN1C(=N)N[C@](C)(c2sc(-c3cccc(-c4ncno4)c3)cc2F)CS1(=O)=O CHEMBL3910228 Ki 0.63 nM
CN1C(=N)N[C@](C)(c2sc(-c3ccc(-c4ccccc4)[nH]3)cc2Cl)CS1(=O)=O CHEMBL3951262 Ki 0.69 nM
CN1C(=N)N[C@](C)(c2sc(-c3cccc(-c4ncco4)c3)cc2F)CS1(=O)=O CHEMBL3949563 Ki 0.73 nM
C[C@@]1(c2cc(NC(=O)c3ncc(Cl)cc3Cl)ccc2F)CS(=O)(=O)C2(CCCC2)C(=N)N1 CHEMBL3985208 Ki 0.8 nM
CN1CC2(C1)C(=N)N[C@](C)(c1cc(NC(=O)c3ncc(C#N)cc3C3CC3)ccc1F)CS2(=O)=O CHEMBL3895721 Ki 0.8 nM
C#CCOc1cnc(C(=O)Nc2cc(F)c(F)c([C@@]3(C)N=C(N)S[C@@]4(C(=O)N(C)C)C[C@H]43)c2)cn1 CHEMBL4472708 IC50 0.8 nM
NC1=N[C@@]2(CO1)c1cc(-c3cccnc3F)ccc1Oc1c2cc(C2=CCCOC2)nc1F CHEMBL4564735 IC50 0.8 nM
COc1cnc(C(=O)Nc2ccc(F)c([C@]34CN(c5ncc(F)cn5)C[C@H]3CSC(N)=N4)c2)cn1 CHEMBL4452566 IC50 0.871 nM
C[C@@]1(c2cc(NC(=O)c3ccc(F)cn3)ccc2F)CS(=O)(=O)C2(CC2)C(=N)N1 CHEMBL3936730 Ki 0.9 nM
COc1cccc2cc(-c3cc(Cl)c([C@]4(C)CS(=O)(=O)[C@]5(CCOC5)C(=N)N4)s3)[nH]c12 CHEMBL3981858 Ki 0.9 nM
COc1cnc(C(=O)Nc2ccc(F)c([C@]3(C)CS(=O)(=O)C4(CN(C)C4)C(=N)N3)c2)c(C)c1 CHEMBL3917191 Ki 0.9 nM
NC1=N[C@@](c2cccc(-c3cncnc3)c2)(c2ccnc(C(F)F)c2)c2cccc(F)c21 CHEMBL2177913 IC50 0.9 nM
CC#Cc1cncc(-c2ccc3c(c2)[C@@]2(N=C(C)C(N)=N2)[C@]2(CC[C@@H](OC)CC2)C3)c1 CHEMBL4217620 IC50 0.9 nM
C[C@]1(c2cc(NC(=O)c3ccc(Cl)cn3)ccc2F)N=C(N)OC[C@@H]1F CHEMBL3680854 IC50 1.0 nM
C[C@]1(c2cc(NC(=O)c3ccc(C(F)F)cn3)ccc2F)N=C(N)OC[C@@H]1F CHEMBL3680863 IC50 1.0 nM
C[C@@]1(c2nc(NC(=O)c3ncc(Cl)cc3Cl)ccc2F)CO[C@@](C)(C(F)(F)F)C(N)=N1 CHEMBL3670372 IC50 1.0 nM
COc1cccc2cc(-c3cc(Cl)c([C@]4(C)CS(=O)(=O)C5(CCC5)C(=N)N4)s3)[nH]c12 CHEMBL3976028 Ki 1.0 nM
COc1cccc2cc(-c3cc(Cl)c([C@]4(C)CS(=O)(=O)C5(CC5)C(=N)N4)s3)[nH]c12 CHEMBL3895258 Ki 1.0 nM
CC1(C)C(=N)N[C@@]2(c3cc(NC(=O)c4ccc(F)cn4)ccc3F)COC[C@H]2S1(=O)=O CHEMBL4109582 Ki 1.0 nM
CC1(C)C(=N)N[C@@]2(c3cc(NC(=O)c4ccc(Cl)cn4)ccc3F)COC[C@H]2S1(=O)=O CHEMBL4111708 Ki 1.0 nM
CC1(C)C(=N)N[C@@]2(c3cc(NC(=O)c4ncc(Cl)cc4F)ccc3F)COC[C@H]2S1(=O)=O CHEMBL4108212 Ki 1.0 nM
Cc1nc(C(=O)Nc2ccc(F)c([C@]34COC[C@H]3S(=O)(=O)C(C)(C)C(=N)N4)c2)c(C)o1 CHEMBL4112190 Ki 1.0 nM
CC1(C)C(=N)N[C@@]2(c3cc(NC(=O)c4ccc(C#N)cn4)ccc3F)COC[C@H]2S1(=O)=O CHEMBL4113105 Ki 1.0 nM
COc1cnc(C(=O)Nc2ccc(F)c([C@]34COC[C@H]3S(=O)(=O)C(C)(C)C(=N)N4)c2)c(C)c1 CHEMBL4113267 Ki 1.0 nM
Cc1cc(C#N)cnc1C(=O)Nc1ccc(F)c([C@]23COC[C@H]2S(=O)(=O)C(C)(C)C(=N)N3)c1 CHEMBL4110175 Ki 1.0 nM
CC1(C)C(=N)N[C@@]2(c3cc(NC(=O)c4cnsn4)ccc3F)COC[C@H]2S1(=O)=O CHEMBL4109231 Ki 1.0 nM
CC1(C)C(=N)N[C@@]2(c3cc(NC(=O)c4ccn(C(F)F)n4)ccc3F)COC[C@H]2S1(=O)=O CHEMBL4107791 Ki 1.0 nM
CC1(C)C(=N)N[C@@]2(c3cc(NC(=O)c4ccc(F)cn4)ccc3F)COC(CF)[C@H]2S1(=O)=O CHEMBL4112004 Ki 1.0 nM
CC1(C)C(=N)N[C@@]2(c3cc(NC(=O)c4ccc(Cl)cn4)ccc3F)COC(CF)[C@H]2S1(=O)=O CHEMBL4110277 Ki 1.0 nM
C[C@@]1(c2ccc(F)cc2)C(=N)N[C@@]2(c3cc(NC(=O)c4ccc(F)cn4)ccc3F)COC[C@H]2S1(=O)=O CHEMBL4112573 Ki 1.0 nM
CN1C(=N)N[C@](C)(c2sc(-c3cncc(-c4ncco4)c3)cc2F)CS1(=O)=O CHEMBL3905209 Ki 1.0 nM
CNS1(O)C[C@@](C)(c2cc(NC(=O)c3ccc(Cl)cn3)ccc2F)NC(=N)C1(C)C CHEMBL3956676 Ki 1.0 nM
CCNS1(O)C[C@@](C)(c2cc(NC(=O)c3ccc(Cl)cn3)ccc2F)NC(=N)C1(C)C CHEMBL3902472 Ki 1.0 nM
CC1(C)C(=N)N[C@](C)(c2cc(NC(=O)c3ccc(Cl)cn3)ccc2F)CS1(O)NCC1CC1 CHEMBL3960086 Ki 1.0 nM
CC1(C)C(=N)N[C@](C)(c2cc(NC(=O)c3ccc(Cl)cn3)ccc2F)CS1(O)NCCF CHEMBL3939154 Ki 1.0 nM
COCCNS1(O)C[C@@](C)(c2cc(NC(=O)c3ccc(Cl)cn3)ccc2F)NC(=N)C1(C)C CHEMBL3933652 Ki 1.0 nM
CNS1(O)C[C@@](C)(c2cc(NC(=O)c3ccc(Cl)cn3)ccc2F)NC(=N)N1C CHEMBL3920380 Ki 1.0 nM
CNS1(O)C[C@@](C)(c2cc(NC(=O)c3ccc(F)cn3)ccc2F)NC(=N)N1C CHEMBL3903739 Ki 1.0 nM
CN1C(=N)N[C@](C)(c2cc(NC(=S)c3ccc(Cl)cn3)ccc2F)CS1(=O)=O CHEMBL3986336 Ki 1.0 nM
Cc1cc(C#N)cnc1C(=O)Nc1ccc(F)c([C@]2(C)CS(=O)(=O)C3(CN(C)C3)C(=N)N2)c1 CHEMBL3922651 Ki 1.0 nM
CN1C(=N)N[C@@]2(c3cc(NC(=O)c4ccc(Cl)cn4)ccc3F)CCC[C@H]2S1(=O)=O CHEMBL4127711 Ki 1.0 nM
CN1C(=N)N[C@@]2(c3cc(NC(=O)c4ncc(Cl)cc4F)ccc3F)CCC[C@H]2S1(=O)=O CHEMBL4129654 Ki 1.0 nM
CN1C(=N)N[C@@]2(c3cc(NC(=O)c4ncc(F)cc4F)ccc3F)CCC[C@H]2S1(=O)=O CHEMBL4126365 Ki 1.0 nM
Cc1cc(F)cnc1C(=O)Nc1ccc(F)c([C@]23CCC[C@H]2S(=O)(=O)N(C)C(=N)N3)c1 CHEMBL4127283 Ki 1.0 nM
C[C@@]1(c2cc(NC(=O)c3ccc(OCF)cn3)ccc2F)C[C@@H](C(F)(F)F)SC(N)=N1 CHEMBL4445405 IC50 1.0 nM
CN=[S@@]1(=O)C[C@@](C)(c2cc(NC(=O)c3ccc(Cl)cn3)ccc2F)N=C(N)C1(C)C CHEMBL4473638 Ki 1.0 nM
CN=[S@@]1(=O)C[C@@](C)(c2cc(NC(=O)c3ccc(Cl)cn3)ccc2F)N=C(N)N1C CHEMBL4534877 Ki 1.0 nM
CN1C(N)=N[C@](C)(c2cc(NC(=S)c3ccc(C#N)cn3)ccc2F)CS1(=O)=O CHEMBL4458706 Ki 1.0 nM
COC[C@]12C[C@H]1[C@@](CF)(c1cc(NC(=O)c3ccc(Cl)cn3)ccc1F)N=C(N)S2 CHEMBL4760131 IC50 1.0 nM
Cc1cc(C(=O)NC(Cc2ccccc2)C(O)CNC(C(=O)NCC(C)C)C(C)O)cc(C(=O)N(C)C(C)c2ccccc2)c1 CHEMBL3704770 Ki 1.005 nM
Cc1nc(-c2cccc(-c3cc(F)c([C@]4(C)CS(=O)(=O)N(C)C(=N)N4)s3)c2)no1 CHEMBL3961454 Ki 1.1 nM
Cc1noc(-c2cc(-c3cc(Cl)c([C@]4(C)CS(=O)(=O)N(C)C(=N)N4)s3)ccn2)n1 CHEMBL3935772 Ki 1.1 nM
COc1ccc(C(=O)Nc2ccc(F)c([C@]3(C)CS(=O)(=O)C4(CN(C(C)=O)C4)C(=N)N3)c2)nc1 CHEMBL3898071 Ki 1.1 nM
COC[C@]12C[C@H]1[C@@](C)(c1cc(NC(=O)c3ccc(Cl)cn3)cc(F)c1F)N=C(N)S2 CHEMBL4456863 IC50 1.1 nM
C[C@@]1(c2cc(NC(=O)c3ncc(Cl)cc3Cl)ccc2F)CS(=O)(=O)C2(CCOCC2)C(=N)N1 CHEMBL3913650 Ki 1.2 nM
CN1CC2(C1)C(=N)N[C@](C)(c1cc(NC(=O)c3ccc(F)cn3)ccc1F)CS2(=O)=O CHEMBL3975362 Ki 1.2 nM
Cc1nc(C(=O)Nc2ccc(F)c([C@]3(C)CS(=O)(=O)C4(CCCC4)C(=N)N3)c2)no1 CHEMBL3900066 Ki 1.3 nM
C[C@@]1(c2cc(NC(=O)c3ccc(Cl)cn3)ccc2F)CS(=O)(=O)[C@@]2(CCOC2)C(=N)N1 CHEMBL3919398 Ki 1.3 nM
CN1C(=N)N[C@@]2(c3cc(NC(=O)c4ccc(Cl)cn4)ccc3F)COC[C@H]2S1(=O)=O CHEMBL4114170 Ki 1.3 nM
CN1C(=N)N[C@](C)(c2sc(-c3cc(F)cc(-c4nnco4)c3)cc2F)CS1(=O)=O CHEMBL3913634 Ki 1.3 nM
C[C@@]1(c2cc(NC(=O)c3ncc(Cl)cc3F)ccc2F)CS(=O)(=O)C2(CCOCC2)C(=N)N1 CHEMBL3969079 Ki 1.4 nM
CN1C(=N)N[C@](C)(c2sc(-c3cccc(-c4ncco4)c3)cc2Cl)CS1(=O)=O CHEMBL3891425 Ki 1.4 nM
CN1CC2(C1)C(=N)N[C@](C)(c1cc(NC(=O)c3ccc(C#N)cn3)ccc1F)CS2(=O)=O CHEMBL3913535 Ki 1.4 nM
COc1cnc(C(=O)Nc2ccc(F)c([C@]3(C)CS(=O)(=O)C4(CCCC4)C(=N)N3)c2)cn1 CHEMBL3948118 Ki 1.5 nM
COc1cccc2cc(-c3cc(Cl)c([C@]4(C)CS(=O)(=O)[C@@]5(CCOC5)C(=N)N4)s3)[nH]c12 CHEMBL3914810 Ki 1.5 nM
CN1CC2(C1)C(=N)N[C@](C)(c1cc(NC(=O)c3ccc(OCF)cn3)ccc1F)CS2(=O)=O CHEMBL3945094 Ki 1.5 nM
COc1nc(N2CC3[C@](c4cc(NC(=O)c5ccc(F)cn5)ccc4F)(C2)NC(=N)N(C)S3(=O)=O)nc(C)c1F CHEMBL4106980 Ki 1.6 nM
C[C@@]1(c2cc(NC(=O)c3ccc(Cl)cn3)ccc2F)CS(=O)(=O)C2(CCOCC2)C(=N)N1 CHEMBL3983399 Ki 1.6 nM
CN1C(=N)N[C@](C)(c2sc(-c3cccc(-n4cccn4)c3)cc2Cl)CS1(=O)=O CHEMBL3944761 Ki 1.6 nM
CN1C(=N)N[C@](C)(c2sc(-c3cccc(-c4ccccc4)c3)cc2Cl)CS1(=O)=O CHEMBL3921452 Ki 1.6 nM
COc1ccc(C(=O)Nc2ccc(F)c([C@]3(C)CS(=O)(=O)C4(CN(C)C4)C(=N)N3)c2)nc1 CHEMBL3937168 Ki 1.6 nM
COCc1cc(OC)nc(N2C[C@@H]3[C@](c4cc(F)ccc4F)(C2)NC(=N)N(C)S3(=O)=O)c1 CHEMBL4114907 Ki 1.7 nM
C[C@@]1(c2cc(NC(=O)c3ccc(F)cn3)ccc2F)CS(=O)(=O)[C@]2(C[C@H](O)C2)C(=N)N1 CHEMBL3891094 Ki 1.7 nM
CNC(=O)N1CC2(C1)C(=N)N[C@](C)(c1cc(NC(=O)c3ccc(OC)cn3)ccc1F)CS2(=O)=O CHEMBL3956741 Ki 1.7 nM
C[C@@]1(c2cc(NC(=O)c3ccc(Cl)cn3)ccc2F)CS(=O)(=O)[C@]2(CCOC2)C(=N)N1 CHEMBL3913185 Ki 1.8 nM
Cc1cc(C#N)cnc1C(=O)Nc1ccc(F)c([C@]2(C)CS(=O)(=O)C3(CNC3)C(=N)N2)c1 CHEMBL3915974 Ki 1.8 nM
C[C@]1(c2cc(NC(=O)c3ccc(Cl)cn3)cc(F)c2F)N=C(N)S[C@H]2C[C@H]21 CHEMBL4460278 IC50 1.8 nM
COc1ccc(C(=O)Nc2ccc(F)c([C@]3(C)CS(=O)(=O)C4(CC4)C(=N)N3)c2)nc1 CHEMBL3905648 Ki 1.9 nM
C[C@@]1(c2cc(NC(=O)c3ccc(Cl)cn3)ccc2F)CS(=O)(=O)C2(CCC2)C(=N)N1 CHEMBL3967867 Ki 1.9 nM
CN1C(=N)N[C@@]2(c3cc(NC(=O)c4ccc(F)cn4)ccc3F)COC[C@H]2S1(=O)=O CHEMBL4108817 Ki 1.9 nM
COc1cnc(C(=O)Nc2ccc(F)c([C@]3(C)CS(=O)(=O)N(C)C(=N)N3)c2)cn1 CHEMBL3672923 Ki 1.99 nM
COc1cccc2cc(-c3cc(Cl)c([C@]4(C)CS(=O)(=O)C5(CCCCC5)C(=N)N4)s3)[nH]c12 CHEMBL3958825 Ki 2.0 nM
COc1cccc2cc(-c3cc(Cl)c([C@]4(C)CS(=O)(=O)C5(CCOCC5)C(=N)N4)s3)[nH]c12 CHEMBL3949683 Ki 2.0 nM
Cn1ccc(C(=O)Nc2ccc(F)c([C@]34COC[C@H]3S(=O)(=O)C(C)(C)C(=N)N4)c2)n1 CHEMBL4106918 Ki 2.0 nM
C#CCOc1cnc(C(=O)Nc2ccc(F)c([C@]34COC[C@H]3S(=O)(=O)C(C)(C)C(=N)N4)c2)cn1 CHEMBL4114508 Ki 2.0 nM
CC1(C)C(=N)N[C@@]2(c3cc(NC(=O)c4ccc(OCF)cn4)ccc3F)COC[C@H]2S1(=O)=O CHEMBL4107721 Ki 2.0 nM
C[C@H]1OC[C@]2(c3cc(NC(=O)c4ccc(F)cn4)ccc3F)NC(=N)C(C)(C)S(=O)(=O)[C@H]12 CHEMBL4107780 Ki 2.0 nM
CN1C(=N)N[C@](C)(c2sc(-c3cccc(-c4cnco4)c3)cc2Cl)CS1(=O)=O CHEMBL3973797 Ki 2.0 nM
CNS1(O)C[C@@](C)(c2cc(NC(=O)c3ccc(F)cn3)ccc2F)NC(=N)C1(C)C CHEMBL3948430 Ki 2.0 nM
COCC(=S)Nc1ccc(F)c([C@]2(C)CS(=O)(=O)N(C)C(=N)N2)c1 CHEMBL3897828 Ki 2.0 nM
CN1C(=N)N[C@](C)(c2cc(NC(=S)c3ccc(F)cn3)ccc2F)CS1(=O)=O CHEMBL3947234 Ki 2.0 nM
CN1C(=N)N[C@](C)(c2cc(NC(=S)c3ccc(Cl)cn3)cc(F)c2F)CS1(=O)=O CHEMBL3932463 Ki 2.0 nM
C[C@@]1(c2cc(NC(=O)c3ncc(Cl)cc3Cl)ccc2F)CO[C@@](C)(C(F)(F)F)C(N)=N1 CHEMBL5085959 IC50 2.0 nM
C[C@@]1(c2cc(NC(=O)c3ccc(C(F)(F)F)cn3)ccc2F)CS(=O)(=O)C2(CCCC2)C(=N)N1 CHEMBL3986161 Ki 2.1 nM
C[C@@]1(c2cc(NC(=O)c3ccc(F)cn3)ccc2F)CS(=O)(=O)C2(CCOCC2)C(=N)N1 CHEMBL3980366 Ki 2.1 nM
COc1cnc(C(=O)Nc2cc(F)c(F)c([C@]3(C)CS(=O)(=O)N(C)C(=N)N3)c2)cn1 CHEMBL3672919 Ki 2.15 nM
C[C@@]1(c2sc(-c3ccnc(-c4ccco4)c3)cc2Cl)CS(=O)(=O)[C@]2(CCOC2)C(=N)N1 CHEMBL3985039 Ki 2.2 nM
CN1C(=N)N[C@](C)(c2sc(-c3cccc(-c4nnc(C5CC5)o4)c3)cc2Cl)CS1(=O)=O CHEMBL3929836 Ki 2.2 nM
Cc1noc(-c2cc(-c3cc(F)c([C@]4(C)CS(=O)(=O)N(C)C(=N)N4)s3)ccn2)n1 CHEMBL3920318 Ki 2.3 nM
COc1ccc(C(=O)Nc2ccc(F)c([C@]3(C)CS(=O)(=O)C4(CN(S(C)(=O)=O)C4)C(=N)N3)c2)nc1 CHEMBL3926149 Ki 2.3 nM
C[C@@]1(c2cc(NC(=O)c3ccc(F)cn3)ccc2F)CS(=O)(=O)C2(CCC(O)C2)C(=N)N1 CHEMBL3965337 Ki 2.4 nM
CN1C(=N)N[C@](C)(c2sc(-c3cccc(-c4ccno4)c3)cc2Cl)CS1(=O)=O CHEMBL3978736 Ki 2.4 nM
CN1C(=N)N[C@](C)(c2cc(NC(=O)c3ccc(C(F)(F)F)cn3)ccc2F)CS1(=O)=O CHEMBL3672917 Ki 2.46 nM
C[C@@]1(c2cc(NC(=O)c3ncc(F)cc3F)ccc2F)CS(=O)(=O)C2(CCC2)C(=N)N1 CHEMBL3948098 Ki 2.5 nM
CN1C(=N)N[C@](C)(c2sc(-c3ccnc(-c4nc(C5CC5)no4)c3)cc2Cl)CS1(=O)=O CHEMBL3944720 Ki 2.5 nM
C[C@@]1(c2cc(NC(=O)c3ccc(C#N)cn3)ccc2F)CS(=O)(=O)C2(CNC2)C(=N)N1 CHEMBL3897125 Ki 2.6 nM
C[C@@]1(c2cc(NC(=O)c3ccc(F)cn3)ccc2F)CS(=O)(=O)[C@@]2(CCOC2)C(=N)N1 CHEMBL3966712 Ki 2.7 nM
C[C@@]1(c2sc(-c3cncc(-c4ncco4)c3)cc2Cl)CS(=O)(=O)[C@]2(CCOC2)C(=N)N1 CHEMBL3906365 Ki 2.8 nM
CC(C)C[C@H](NC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)[C@@H](O)C[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(C)C CHEMBL390456 Ki(app) 3.0 nM
COc1ccc(C(=O)Nc2ccc(F)c([C@]34COC[C@H]3S(=O)(=O)C(C)(C)C(=N)N4)c2)nc1 CHEMBL4108703 Ki 3.0 nM
CC1(C)C(=N)N[C@@]2(c3cc(NC(=O)c4cn5ccsc5n4)ccc3F)COC[C@H]2S1(=O)=O CHEMBL4113810 Ki 3.0 nM
COc1ccc(C(=O)Nc2ccc(F)c([C@]34COC(CF)[C@H]3S(=O)(=O)C(C)(C)C(=N)N4)c2)nc1 CHEMBL4112582 Ki 3.0 nM
CN1C(=N)N[C@](C)(c2sc(-c3cccc(-c4noc(C5CC5)n4)c3)cc2F)CS1(=O)=O CHEMBL3925066 Ki 3.0 nM
CCNS1(O)C[C@@](C)(c2cc(NC(=O)c3ccc(F)cn3)ccc2F)NC(=N)C1(C)C CHEMBL3914900 Ki 3.0 nM
CCN=S1(=O)C[C@@](C)(c2cc(NC(=O)c3ccc(Cl)cn3)ccc2F)NC(=N)N1C CHEMBL3891223 Ki 3.0 nM
CCN1C(=N)N[C@](C)(c2cc(NC(=O)c3ccc(Cl)cn3)ccc2F)CS1(=O)=NC CHEMBL3919305 Ki 3.0 nM
CN1C(=N)N[C@](C)(c2cc(NC(=S)c3ccc(F)cn3)cc(F)c2F)CS1(=O)=O CHEMBL3981430 Ki 3.0 nM
CN1CCC2(CC1)C(=N)N[C@](C)(c1cc(NC(=O)c3ccc(Cl)cn3)ccc1F)CS2(=O)=O CHEMBL3948757 Ki 3.0 nM
CN1C(=N)N[C@@]2(c3cc(NC(=O)c4ccc(C#N)cn4)ccc3F)CCC[C@H]2S1(=O)=O CHEMBL4129113 Ki 3.0 nM
Cc1ccc(C(=O)Nc2ccc(F)c([C@]34CCC[C@H]3S(=O)(=O)N(C)C(=N)N4)c2)nc1 CHEMBL4127870 Ki 3.0 nM
C[C@@]1(c2cc(NC(=O)c3ccc(F)cn3)ccc2F)Cc2ncncc2C(N)=N1 CHEMBL4439298 Ki 3.0 nM
C[C@@]1(c2cc(NC(=O)c3ccc(Br)cn3)ccc2F)CO[C@@](C)(C(F)(F)F)C(N)=N1 CHEMBL3653401 IC50 3.0 nM
C[C@@]1(c2cc(NC(=O)c3ncc(Br)cn3)ccc2F)CO[C@@](C)(C(F)(F)F)C(N)=N1 CHEMBL3653404 IC50 3.0 nM
NC1=N[C@](CF)(c2cc(NC(=O)c3cnc(Cl)cn3)cc(F)c2F)[C@H]2[C@@H](S1)C2(F)F CHEMBL4449357 IC50 3.02 nM
C[C@@]1(c2cc(NC(=O)c3cnsn3)ccc2F)CS(=O)(=O)C2(CCCC2)C(=N)N1 CHEMBL3909483 Ki 3.1 nM
C[C@@]1(S(C)(=O)=O)CC[C@@](CF)(c2cc(NC(=O)c3ccc(F)cn3)ccc2F)N=C1N CHEMBL5074719 IC50 3.1 nM
COCc1cc(OC)nc(N2CC3[C@](c4cc(F)c(F)cc4F)(C2)NC(=N)N(C)S3(=O)=O)c1 CHEMBL4107294 Ki 3.2 nM
CC(=O)N1CC2[C@](c3cc(NC(=O)c4ccc(F)cn4)ccc3F)(C1)NC(=N)N(C)S2(=O)=O CHEMBL4110120 Ki 3.2 nM
C[C@@]1(c2sc(-c3cncc(C#N)c3)cc2Cl)CS(=O)(=O)C2(CCCC2)C(=N)N1 CHEMBL3936799 Ki 3.4 nM
COC[C@H]1C[C@@H]2[C@](c3cc(Oc4cc(C#N)ccn4)ccc3F)(CO1)N=C(N)N(C)S2(=O)=O CHEMBL4567636 Ki 3.4 nM
CN1C(=N)N[C@](C)(c2sc(-c3cccc(-c4ccno4)c3)cc2F)CS1(=O)=O CHEMBL3892917 Ki 3.5 nM
COc1cnc2c(Nc3ccc(F)c([C@]4(C)CS(=O)(=O)N(C)C(N)=N4)c3)nccc2c1 CHEMBL4451647 Ki 3.5 nM
Cc1noc(-c2cccc(-c3cc(F)c([C@]4(C)CS(=O)(=O)N(C)C(=N)N4)s3)c2)n1 CHEMBL3947414 Ki 3.6 nM
CN1C(=N)N[C@](C)(c2sc(-c3cccc(-c4cnco4)c3)cc2F)CS1(=O)=O CHEMBL3949670 Ki 3.7 nM
C[C@@]1(c2cc(NC(=O)c3ccc(F)cn3)ccc2F)CS(=O)(=O)C2(CC(O)C2)C(=N)N1 CHEMBL3984091 Ki 3.8 nM
Cc1nnc(-c2cccc(-c3cc(Cl)c([C@]4(C)CS(=O)(=O)N(C)C(=N)N4)s3)c2)o1 CHEMBL3917414 Ki 3.8 nM
CC(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNC1CC(C)(C)Oc2sc(CC(C)(C)C)cc21 CHEMBL2158253 IC50 3.9 nM
CN1C(=N)N[C@](C)(c2sc(-c3cc(-c4nnco4)ccc3F)cc2F)CS1(=O)=O CHEMBL3903571 Ki 3.9 nM
C[C@H]1C[C@H]2CSC(N)=N[C@@]2(c2nc(NC(=O)c3ccn(C(F)F)n3)cs2)CO1 CHEMBL4215837 IC50 3.9 nM
C[C@]1(c2nc(NC(=O)c3ncc(Cl)cc3Cl)ccc2F)N=C(N)OCC1(F)F CHEMBL2386724 IC50 4.0 nM
C[C@]1(F)COC(N)=N[C@]1(C)c1cc(NC(=O)c2ncc(Cl)cc2Cl)ccc1F CHEMBL3680890 IC50 4.0 nM
C[C@@H]1OC[C@]2(c3cc(NC(=O)c4ccc(F)cn4)ccc3F)NC(=N)C(C)(C)S(=O)(=O)[C@H]12 CHEMBL3974476 Ki 4.0 nM
COc1cnc(C(=S)Nc2ccc(F)c([C@]3(C)CS(=O)(=O)N(C)C(=N)N3)c2)cn1 CHEMBL3910526 Ki 4.0 nM
C[C@@]1(c2cc(NC(=O)c3ncc(C#N)cn3)ccc2F)CO[C@@](C)(C(F)(F)F)C(N)=N1 CHEMBL3653403 IC50 4.0 nM
COc1cnc(C(=O)Nc2ccc(F)c([C@]3(C)CO[C@@](C)(C(F)(F)F)C(N)=N3)c2)c(C)c1 CHEMBL5075177 IC50 4.0 nM
C[C@@]1(c2cc(NC(=O)c3ccc(F)cn3)ccc2F)CS(=O)(=O)C2(CCC2)C(=N)N1 CHEMBL3923790 Ki 4.2 nM
Cc1nnc(-c2cccc(-c3cc(F)c([C@]4(C)CS(=O)(=O)N(C)C(=N)N4)s3)c2)o1 CHEMBL3901897 Ki 4.2 nM
CN1C(=N)N[C@](C)(c2sc(-c3cccc(-c4nnc(C5CC5)o4)c3)cc2F)CS1(=O)=O CHEMBL3914118 Ki 4.2 nM
CN1C(=N)N[C@](C)(c2sc(-c3cc(-c4nnco4)ccc3F)cc2Cl)CS1(=O)=O CHEMBL3904651 Ki 4.2 nM
C[C@@]1(c2cc(NC(=O)c3ccn(C(F)F)n3)ccc2F)CS(=O)(=O)C2(CCCC2)C(=N)N1 CHEMBL3913008 Ki 4.3 nM
C[C@@]1(c2cc(NC(=O)c3ccc(F)cn3)ccc2F)CS(=O)(=O)[C@]2(CCOC2)C(=N)N1 CHEMBL3983037 Ki 4.3 nM
CN1CC2(C1)C(=N)N[C@](C)(c1cc(NC(=O)c3ccc(OC(F)F)cn3)ccc1F)CS2(=O)=O CHEMBL3915968 Ki 4.3 nM
C[C@@]1(c2cc(NC(=O)c3ccc(F)cn3)ccc2F)CS(=O)(=O)C2(CCCCC2)C(=N)N1 CHEMBL3919160 Ki 4.4 nM
CC(C)C[C@H](NC(=O)[C@@H]1CC(=O)NCCCCCCOC(=O)N[C@@H](C(C)C)C(=O)N1)[C@@H](O)C[C@@H](C)C(=O)N[C@H](C(=O)NCc1ccccc1)C(C)C CHEMBL362592 Ki 4.5 nM
CC(=O)N[C@@H](Cc1ccccc1)[C@H](O)CN[C@H]1CC(C)(C)Oc2ccc(CC(C)(C)C)cc21 CHEMBL2158252 IC50 4.5 nM
Cc1noc(-c2cccc(-c3cc(Cl)c([C@]4(C)CS(=O)(=O)N(C)C(=N)N4)s3)c2)n1 CHEMBL3921432 Ki 4.6 nM
CN1C(=N)N[C@](C)(c2sc(-c3cccc(-n4nccn4)c3)cc2Cl)CS1(=O)=O CHEMBL3893436 Ki 4.7 nM
CN1C(=N)N[C@](C)(c2sc(-c3cc(F)cc(-c4cnco4)c3)cc2Cl)CS1(=O)=O CHEMBL3900560 Ki 4.8 nM
CN1C(=N)N[C@](C)(c2sc(-c3cc(F)cc(-c4cnco4)c3)cc2F)CS1(=O)=O CHEMBL3913054 Ki 4.8 nM
Cc1cnc(C(=O)Nc2ccc(F)c([C@]3(C)CS(=O)(=O)N(C)C(=N)N3)c2)cn1 CHEMBL3672918 Ki 4.85 nM
COc1cnc(C(=O)Nc2ccc(F)c([C@]3(C)CS(=O)(=O)C4(CN(C)C4)C(=N)N3)c2)c(C)n1 CHEMBL3926065 Ki 4.9 nM
CC1(C#Cc2cnc3c(c2)[C@]2(COC(N)=N2)c2cc(-c4cccnc4F)ccc2O3)COC1 CHEMBL3359763 IC50 5.0 nM
CC1(C)OCC(N)=N[C@](C)(c2cc(N[C@H]3CCc4cc(C#N)cnc43)ccc2F)C1(F)F CHEMBL3670914 IC50 5.0 nM
C[C@@]1(c2cccc(NC(=O)c3ncc(Br)cc3Cl)n2)CO[C@@](C)(C(F)(F)F)C(N)=N1 CHEMBL3670363 IC50 5.0 nM
C[C@@]1(c2nc(NC(=O)c3nn(C(F)F)cc3Cl)ccc2F)CO[C@@](C)(C(F)(F)F)C(N)=N1 CHEMBL3670387 IC50 5.0 nM
COCc1cc(OC)nc(N2CC3[C@](c4ccccc4F)(C2)NC(=N)N(C)S3(=O)=O)c1 CHEMBL4114606 Ki 5.0 nM
COc1cnc(C(=O)Nc2ccc(F)c([C@]34COC[C@H]3S(=O)(=O)C(C)(C)C(=N)N4)c2)cn1 CHEMBL4111329 Ki 5.0 nM
COCC(=O)Nc1ccc(F)c([C@]23COC[C@H]2S(=O)(=O)C(C)(C)C(=N)N3)c1 CHEMBL4107392 Ki 5.0 nM
CNS1(O)C[C@@](C)(c2cc(NC(=O)c3ccc(OC)cn3)ccc2F)NC(=N)C1(C)C CHEMBL3953747 Ki 5.0 nM
CCNS1(O)C[C@@](C)(c2cc(NC(=O)c3ccc(C#N)cn3)ccc2F)NC(=N)C1(C)C CHEMBL3985262 Ki 5.0 nM
Cc1cc(C#N)cnc1C(=O)Nc1ccc(F)c([C@]2(C)CO[C@@](C)(C(F)(F)F)C(N)=N2)c1 CHEMBL3261067 IC50 5.0 nM
C[C@@]1(c2cc(NC(=O)c3ncc(C#N)cc3Cl)ccc2F)CO[C@@](C)(C(F)(F)F)C(N)=N1 CHEMBL5073160 IC50 5.0 nM
C[C@@]1(c2cc(NC(=O)c3ncc(C#N)cc3N)ccc2F)CO[C@@](C)(C(F)(F)F)C(N)=N1 CHEMBL5090563 IC50 5.0 nM
C[C@@]1(c2cc(NC(=O)c3ccc(C#N)cn3)ccc2F)Cn2nncc2C(N)=N1 CHEMBL4441612 IC50 5.3 nM
C[C@@H]1C[C@H]1COC(C)(C)[C@@H]1C[C@H]1[C@]12CN(c3ncccn3)C[C@H]1CSC(N)=N2 CHEMBL4637426 IC50 5.3 nM
COC[C@H]1CCCN1C(=O)c1cc(C)cc(C(=O)N[C@@H](Cc2cc(F)cc(F)c2)[C@H](O)[C@H]2CN(S(=O)(=O)c3cccc(C)c3)CCN2)c1 CHEMBL1097342 Ki 5.4 nM
COc1nc(N2C[C@@H]3[C@](c4ccccc4F)(C2)NC(=N)N(C)S3(=O)=O)nc(C)c1F CHEMBL4110695 Ki 5.4 nM
C[C@@]1(c2cc(NC(=O)c3ccc(C#N)cn3)ccc2F)C=CSC(N)=N1 CHEMBL3916243 IC50 5.6 nM
COc1nc(N2CC3C(c4ccccc4)(C2)NC(=N)N(C)S3(=O)=O)nc(C2CC2)c1F CHEMBL3927352 Ki 5.7 nM
CN1C(=N)N[C@](C)(c2ncc(-c3cccc(-c4ncco4)c3)s2)CS1(=O)=O CHEMBL3959554 Ki 5.7 nM
C[C@]1(c2cc(/C=C(\F)c3ccc(C#N)cn3)ccc2F)N=C(N)S[C@@]2(C(=O)N3CCOCC3)C[C@H]21 CHEMBL4760458 IC50 5.8 nM
C[C@]1(F)COC(N)=N[C@]1(C)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F CHEMBL3680892 IC50 6.0 nM
C[C@]1(c2cc(NC(=O)c3ncc(Cl)cc3F)ccc2F)N=C(N)OC[C@@H]1F CHEMBL3680860 IC50 6.0 nM
COc1cnc(C(=O)Nc2ccc(F)c([C@]34COC[C@H]3S(=O)(=O)C(C)(C)C(=N)N4)c2)c(C)n1 CHEMBL4113860 Ki 6.0 nM
C[C@@]1(C2CC2)C(=N)N[C@@]2(c3cc(NC(=O)c4ccc(F)cn4)ccc3F)COC[C@H]2S1(=O)=O CHEMBL4111108 Ki 6.0 nM
CN1C(=N)N[C@](C)(c2sc(-c3cccc(-c4nnco4)c3)cc2Cl)CS1(=O)=O CHEMBL3985789 Ki 6.0 nM
COCC(=S)Nc1cc(F)c(F)c([C@]2(C)CS(=O)(=O)N(C)C(=N)N2)c1 CHEMBL3895885 Ki 6.0 nM
CN1C(=N)N[C@@]2(c3cc(NC(=O)c4ccc(OC(F)F)cn4)ccc3F)CCC[C@H]2S1(=O)=O CHEMBL4130055 Ki 6.0 nM
COc1cnc(C(=O)Nc2ccc(F)c([C@]34CCC[C@H]3S(=O)(=O)N(C)C(=N)N4)c2)c(C)n1 CHEMBL4125904 Ki 6.0 nM
COc1cnc(C(=O)Nc2ccc(F)c([C@]3(C)CS(=O)(=O)C4(C[O+](C)C4)C(=N)N3)c2)cn1 CHEMBL4110849 Ki 6.2 nM
COCc1cc(OC)nc(N2CC3C(c4ccccc4)(C2)NC(=N)N(C)S3(=O)=O)c1 CHEMBL3915783 Ki 6.4 nM
CN1CCC2(CC1)C(=N)N[C@](C)(c1cc(NC(=O)c3ccc(F)cn3)ccc1F)CS2(=O)=O CHEMBL3916477 Ki 6.4 nM
CN1C(=N)N[C@](C)(c2cc(-c3cc(F)cc(-c4nnco4)c3)cs2)CS1(=O)=O CHEMBL3937537 Ki 6.5 nM
COc1ncc(CC2CCOCC2)c2c1C[C@]1(c3ccc(F)cc3F)N=C(N)SC[C@@H]1C2 CHEMBL4530208 IC50 6.6 nM
CCOCc1cc(OC)nc(N2CC3C(c4ccccc4)(C2)NC(=N)N(C)S3(=O)=O)c1 CHEMBL3900282 Ki 6.7 nM
CN1C(=N)N[C@](C)(c2sc3c(-c4ccc(-c5cc(C(F)(F)F)n[nH]5)cc4)nccc3c2Cl)CS1(=O)=O CHEMBL3946080 Ki 6.7 nM
C[C@H]1C[C@H]2CC(F)(F)C(N)=N[C@@]2(c2cc(NC(=O)c3cnc(OCF)cn3)ccc2F)CO1 CHEMBL4648883 IC50 6.8 nM
COc1cnc(C(=O)Nc2ccc(F)c([C@]34COC[C@H]3S(=O)(=O)N(C)C(=N)N4)c2)c(F)c1 CHEMBL4112319 Ki 6.9 nM
C[C@]1(c2nc(NC(=O)c3nn(C(F)F)cc3Cl)ccc2F)N=C(N)OCC1(F)F CHEMBL2386726 IC50 7.0 nM
C[C@]1(c2cc(NC(=O)c3ccc(F)cn3)ccc2F)N=C(N)OC[C@@H]1F CHEMBL3680872 IC50 7.0 nM
C[C@]1(c2cc(NC(=O)c3ncc(F)cc3F)ccc2F)N=C(N)OC[C@@H]1F CHEMBL3680856 IC50 7.0 nM
Cc1cc(OCF)cnc1C(=O)Nc1ccc(F)c([C@]2(C)CO[C@@](C)(C(F)(F)F)C(N)=N2)n1 CHEMBL3670373 IC50 7.0 nM
C#CCOc1ccc(C(=O)Nc2ccc(F)c([C@]34COC[C@H]3S(=O)(=O)C(C)(C)C(=N)N4)c2)nc1 CHEMBL4112828 Ki 7.0 nM
CN1C(=N)N[C@](C)(c2cc(NC(=S)C(F)F)ccc2F)CS1(=O)=O CHEMBL3985231 Ki 7.0 nM
CN1C(=N)N[C@](C)(c2cc(NC(=S)c3ccc(C(F)(F)F)cn3)ccc2F)CS1(=O)=O CHEMBL3922951 Ki 7.0 nM
C[C@@]1(c2cc(NC(=O)c3ccc(C#N)cn3)ccc2F)CO[C@@](C)(C(F)(F)F)C(N)=N1 CHEMBL3653405 IC50 7.0 nM
CC(C)C[C@H](NC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)[C@@H](O)C[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(N)=O)C(C)C CHEMBL3588999 Ki(app) 7.3 nM
CC#Cc1cncc(-c2cccc([C@@]3(c4cc(C)c(=O)n(CC)c4)N=C(N)c4c(F)cccc43)c2)c1 CHEMBL2152903 Ki 7.5 nM
CN1C(=N)N[C@](C)(c2sc(-c3nnc(-c4ccccc4)o3)cc2Cl)CS1(=O)=O CHEMBL3967197 Ki 7.762 nM
COc1cccc(-c2cccc(C3(C4CC4)NC(=N)N(C)C3=O)c2)c1 CHEMBL2012001 Ki 7.8 nM
C[C@]1(c2cc(NC(=O)c3ncc(Cl)cc3Cl)ccc2F)N=C(N)OC[C@@H]1F CHEMBL3680855 IC50 8.0 nM
CC1(C)C(=N)N[C@@]2(c3cc(NC(=O)c4ccc(C(F)(F)F)cn4)ccc3F)COC[C@H]2S1(=O)=O CHEMBL4108059 Ki 8.0 nM
COc1ccc(C(=S)Nc2ccc(F)c([C@]3(C)CS(=O)(=O)N(C)C(=N)N3)c2)nc1 CHEMBL3957619 Ki 8.0 nM
COc1ccc(C(=O)Nc2ccc(F)c([C@]34COC[C@H]3S(=O)(=O)N(C)C(=N)N4)c2)nc1 CHEMBL4109445 Ki 8.2 nM
CN1C(=N)N[C@](C)(c2cc(-c3ccc(F)c(C#N)c3)cs2)CS1(=O)=O CHEMBL3672922 Ki 8.23 nM
Cc1nnc(-c2ccc(-c3cc(Cl)c([C@]4(C)CS(=O)(=O)N(C)C(=N)N4)s3)[nH]2)o1 CHEMBL3904722 Ki 8.243 nM
CN1CCC2(CC1)C(=N)N[C@](C)(c1cc(NC(=O)c3ccc(C#N)cn3)ccc1F)CS2(=O)=O CHEMBL3900954 Ki 8.4 nM
COc1nc(N2CC3[C@](c4ccc(F)cc4F)(C2)NC(=N)N(C)S3(=O)=O)nc(C)c1F CHEMBL4106803 Ki 8.5 nM
C[C@@]1(c2cc(NC(=O)c3ccc(Cl)cn3)ccc2F)CCSC(N)=N1 CHEMBL2347211 IC50 8.7 nM
CN1C(=N)N[C@](C)(c2sc(-c3cncc(-c4nnco4)c3)cc2F)CS1(=O)=O CHEMBL3924686 Ki 8.9 nM
CN1C(=N)N[C@](C)(c2sc(-c3cncc(-c4cnco4)c3)cc2Cl)CS1(=O)=O CHEMBL3923100 Ki 8.9 nM
NC1=N[C@@]2(c3cc(NC(=O)c4cnc(OCF)cn4)ccc3F)CO[C@@H](CF)C[C@H]2CC1(F)F CHEMBL4636350 IC50 8.9 nM
C[C@]1(c2cc(NC(=O)c3ccc(C#CC4CC4)cn3)ccc2F)N=C(N)OC[C@@H]1F CHEMBL3680866 IC50 9.0 nM
C[C@]1(c2ccc(F)cc2)C(=N)N[C@@]2(c3cc(NC(=O)c4ccc(F)cn4)ccc3F)COC[C@H]2S1(=O)=O CHEMBL4115588 Ki 9.0 nM
COc1cnc2c(C(=O)Nc3ccc(F)c([C@]45CCC[C@H]4S(=O)(=O)N(C)C(=N)N5)c3)nccc2n1 CHEMBL4127138 Ki 9.0 nM
CC1(C)C(N)=N[C@@]2(CCOc3ccc(NC(=O)c4ccc(C#N)cn4)cc32)CS1(=O)=O CHEMBL4449989 Ki 9.0 nM
Cc1cc(C#N)cnc1C(=O)Nc1ccc(F)c([C@]2(C)CO[C@@](C)(C(F)(F)F)C(N)=N2)n1 CHEMBL3261069 IC50 9.0 nM
CN1C(=N)N[C@](C)(c2sc(-c3cccc(-c4nc(C5CC5)no4)c3)cc2F)CS1(=O)=O CHEMBL3968289 Ki 9.5 nM
C[C@H]1SC(N)=N[C@](C)(c2cc(NC(=O)c3cc4c(cn3)OCCO4)ccc2F)[C@H]1F CHEMBL5075689 Ki 9.6 nM
C#CCOc1cnc(C(=O)Nc2cc(F)c(F)c([C@@]3(C)N=C(N)S[C@@]4(C(F)F)C[C@@H]34)c2)cn1 CHEMBL4577527 IC50 9.7 nM
CN1C(=N)N[C@](C)(c2sc(-c3cccc(-c4nc(C5CC5)no4)c3)cc2Cl)CS1(=O)=O CHEMBL3944146 Ki 9.9 nM
Cc1cc(Cl)cnc1C(=O)Nc1ccc(F)c([C@@]2(C)N=C(N)OCC2(F)F)c1 CHEMBL2347192 IC50 10.0 nM
C[C@]1(c2cc(NC(=O)c3ccc(Cl)cn3)ccc2F)N=C(N)SCC1(F)F CHEMBL2347212 IC50 10.0 nM
C[C@]1(c2cc(NC(=O)c3ncc(C#N)cc3Cl)ccc2F)N=C(N)OC[C@@H]1F CHEMBL3680859 IC50 10.0 nM
C[C@@]1(c2nc(NC(=O)c3ncc(C#N)cc3Cl)ccc2F)CO[C@@](C)(C(F)(F)F)C(N)=N1 CHEMBL3670365 IC50 10.0 nM
COc1nc(N2CC3C(c4ccccc4)(C2)NC(=N)N(C)S3(=O)=O)nc(OC)c1F CHEMBL3985536 Ki 10.0 nM
C[C@@]1(c2cc(Nc3ccccc3OCC(F)F)ccc2F)COCC(N)=N1 CHEMBL3935621 IC50 10.0 nM
CN1C(=N)N[C@](C)(c2sc(-c3ccc(F)c(-c4nnco4)c3)cc2Cl)CS1(=O)=O CHEMBL3928041 Ki 10.0 nM
CNS1(O)C[C@@](C)(c2cc(NC(=O)COC)ccc2F)NC(=N)C1(C)C CHEMBL3893492 Ki 10.0 nM
COc1cnc2c(C(=O)Nc3ccc(F)c([C@]45CCC[C@H]4S(=O)(=O)N(C)C(=N)N5)c3)nccc2c1 CHEMBL4128525 Ki 10.0 nM
NC1=N[C@@]2(c3cc(NC(=O)c4ccc(F)cn4)ccc3F)CCC[C@H]2CS1 CHEMBL4205912 IC50 10.2 nM
NC1=N[C@@]2(c3cc(NC(=O)c4ccc(F)cn4)ccc3F)COC[C@H]2CS1 CHEMBL2396989 IC50 10.2 nM
NC1=N[C@@]2(c3cc(NC(=O)c4cnc(OCF)cn4)ccc3F)COCC[C@H]2CC1(F)F CHEMBL4637358 IC50 10.2 nM
CN1CC2(C1)C(=N)N[C@](C)(c1cc(NC(=O)c3ccc(OC(F)(F)F)cn3)ccc1F)CS2(=O)=O CHEMBL3940488 Ki 10.3 nM
CN1C(=N)N[C@](C)(c2sc(-c3nnc(-c4ccc(F)cc4)o3)cc2Cl)CS1(=O)=O CHEMBL3975679 Ki 10.64 nM
CN1C(=N)N[C@](C)(c2sc(-c3ccc(-c4nnco4)[nH]3)cc2Cl)CS1(=O)=O CHEMBL3971418 Ki 10.9 nM
COc1cncc(-c2cccc(C3(C4CC4)NC(=N)N(C)C3=O)c2)c1 CHEMBL2012004 Ki 11.0 nM
CCC[C@H](O)[C@H](NC[C@H](Cc1ccccc1)NC(=O)c1cc2c3c(c1)c(CC)cn3CC(C)(C)S(=O)(=O)N2C)C(=O)NCC(C)C CHEMBL2179138 Ki 11.0 nM
C[C@]1(c2cc(NC(=O)c3nn(C(F)F)cc3Cl)ccc2F)N=C(N)OCC1(F)F CHEMBL2347202 IC50 11.0 nM
C[C@]1(c2cc(NCc3nn(C(F)F)cc3Cl)ccc2F)N=C(N)COCC1(F)F CHEMBL3670909 IC50 11.0 nM
CCCC(O)N(NC[C@H](Cc1ccccc1)NC(=O)c1cc2c3c(c1)c(CC)cn3CC1(CC1)S(=O)(=O)N2C)C(=O)NCC(C)C CHEMBL3704774 Ki 11.0 nM
NC1=N[C@@](c2cc(Nc3nccc4cc(Br)cnc34)ccc2F)(C(F)F)COC1 CHEMBL3913980 IC50 11.0 nM
C[C@@]1(c2cc(Nc3ncnc4cc(Cl)cnc34)ccc2F)CO[C@@](C)(C(F)(F)F)C(N)=N1 CHEMBL3973309 IC50 11.0 nM
COc1cnc(C(=O)Nc2ccc(F)c([C@]34COC(CF)[C@H]3S(=O)(=O)C(C)(C)C(=N)N4)c2)cn1 CHEMBL4107633 Ki 11.0 nM
C[C@]1(C2CC2)C(=N)N[C@@]2(c3cc(NC(=O)c4ccc(F)cn4)ccc3F)COC[C@H]2S1(=O)=O CHEMBL4112488 Ki 11.0 nM
CN1C(=N)N[C@](C)(c2sc(-c3ccc(F)c(-c4nnco4)c3)cc2F)CS1(=O)=O CHEMBL3891075 Ki 11.0 nM
CN1CCC2(CC1)C(=N)N[C@](C)(c1cc(NC(=O)c3ccc(OCF)cn3)ccc1F)CS2(=O)=O CHEMBL3958480 Ki 11.0 nM
CN1C(=N)N[C@](C)(c2sc(-c3ccc(-c4nnc(C5CC5)o4)[nH]3)cc2Cl)CS1(=O)=O CHEMBL3932724 Ki 11.29 nM
COc1cnc(C(=O)Nc2ccc(F)c([C@]3(C)Cn4nc(C#N)cc4C(N)=N3)c2)cn1 CHEMBL5074068 IC50 11.5 nM
CC(C)C[C@H](NC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)P(=O)(O)CC(C)C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(C)C CHEMBL242315 IC50 12.0 nM
C[C@]1(c2cc(NC(=O)c3ncc(Cl)cc3Cl)ccc2F)N=C(N)OCC1(F)F CHEMBL2347193 IC50 12.0 nM
C[C@@]1(c2nc(NC(=O)c3ncc(C#N)cc3N)ccc2F)CO[C@@](C)(C(F)(F)F)C(N)=N1 CHEMBL3670368 IC50 12.0 nM
CN1C(=N)N[C@](C)(c2sc(-c3ccnc(-c4ccccc4)c3)cc2F)CS1(=O)=O CHEMBL3898798 Ki 12.0 nM
CNS1(O)C[C@@](C)(c2cc(NC(=O)c3cnc(OC)cn3)ccc2F)NC(=N)C1(C)C CHEMBL3962501 Ki 12.0 nM
CNS1(O)C[C@@](C)(c2cc(NC(=O)c3ccc(OC)cn3)ccc2F)NC(=N)N1C CHEMBL3889548 Ki 12.0 nM
C#CCOc1cnc(C(=O)Nc2cc(F)c(F)c([C@@]3(C)N=C(N)S[C@@]4(CF)C[C@H]43)c2)cn1 CHEMBL4437161 IC50 12.0 nM
Cc1cc(OC(F)F)cnc1C(=O)Nc1ccc(F)c([C@]2(C)CO[C@@](C)(C(F)(F)F)C(N)=N2)c1 CHEMBL5086270 IC50 12.0 nM
CC(C)C[C@H](NC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)[C@@H](O)C[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)O)C(C)C CHEMBL3589002 Ki(app) 12.7 nM
CN1C(=O)C(C)(C)[C@@](C)(c2cc(Nc3ccc(C#N)cc3OC(F)(F)F)ccc2F)N=C1N CHEMBL3649689 IC50 13.0 nM
CO[C@H]1CC[C@]2(CC1)Cc1ccc(-c3cc(Cl)cc(C#N)c3)cc1[C@@]21COC(N)=N1 CHEMBL4072118 Ki 13.0 nM
COc1cc(C#N)cc(-c2ccc3c(c2)[C@@]2(COC(N)=N2)[C@]2(CC[C@H](OC)CC2)C3)c1 CHEMBL4084381 Ki 13.0 nM
[2H]C1([2H])OC(N)=N[C@]12c1cc(-c3cc(C#N)cc(OC)c3)ccc1C[C@]21CC[C@@H](OC)CC1 CHEMBL4100832 Ki 13.0 nM
C[C@]1(c2cc(NC(=O)c3cnc(OCF)cn3)ccc2F)N=C(N)SC[C@H]1c1ccccc1 CHEMBL4463201 IC50 13.0 nM
NC1=N[C@](CF)(c2cc(NC(=O)c3cnc(Cl)cn3)ccc2F)[C@@H]2C[C@]2(C(F)F)S1 CHEMBL4460912 IC50 13.2 nM
CN1C(=N)N[C@](C)(c2sc(-c3nnc(-c4ccc(Cl)cc4)o3)cc2F)CS1(=O)=O CHEMBL3907101 Ki 13.6 nM
CN1C(=N)N[C@](C)(c2sc(-c3nnc(-c4ccc(Cl)cc4)o3)cc2Cl)CS1(=O)=O CHEMBL3915893 Ki 13.79 nM
CN1C(=N)N[C@](C)(c2sc(-c3cccc(-c4nnco4)c3)cc2F)CS1(=O)=O CHEMBL3918648 Ki 13.8 nM
CN1C(=O)C(C)(C)[C@@](C)(c2cc(Nc3ccc(C#N)cc3Cl)ccc2F)N=C1N CHEMBL3649696 IC50 14.0 nM
COc1nc(N2C[C@@H]3[C@](c4ccc(F)cc4)(C2)NC(=N)N(C)S3(=O)=O)nc(C)c1F CHEMBL4114642 Ki 14.0 nM
COc1nc(N2C[C@@H]3[C@](c4cc(F)ccc4F)(C2)NC(=N)N(C)S3(=O)=O)nc(C)c1F CHEMBL4114151 Ki 14.0 nM
C[C@@]1(c2cc(NC(=O)c3ccc(F)cn3)ccc2F)CCSC(N)=N1 CHEMBL4582946 IC50 14.0 nM
CN1C(N)=N[C@](C)(c2cc(NC(=O)c3ccc(F)cn3)ccc2F)C2(CCN(CCC(F)(F)F)C2)S1(=O)=O CHEMBL4476845 Ki 14.0 nM
CN1C(N)=N[C@]2(C)c3cc(NC(=O)c4ccc(C#N)cn4)ccc3OCC[C@H]2S1(=O)=O CHEMBL4455948 Ki 14.0 nM
CN(C)C(=O)[C@]12C[C@H]1[C@@](C)(c1cc(/C=C(\F)c3ccc(C#N)cn3)ccc1F)N=C(N)S2 CHEMBL4790663 IC50 14.0 nM
CC(C)C[C@H](NC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)[C@@H](O)C[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(N)=O)C(C)C CHEMBL3589000 Ki(app) 14.2 nM
C[C@H]1OC[C@]2(c3cc(NC(=O)c4ccc(C#N)cn4)ccc3F)N=C(N)[C@](C)(C#N)C[C@H]12 CHEMBL4561901 IC50 14.5 nM
CN1C(=N)N[C@](C)(c2sc(-c3ncc(-c4ccccc4)[nH]3)cc2Cl)CS1(=O)=O CHEMBL3927055 Ki 14.76 nM
C[C@]1(c2cc(NC(=O)c3ccc(Cl)cn3)ccc2F)N=C(N)OCC1(F)F CHEMBL2347210 IC50 15.0 nM
CC(C)(C)COc1ccc2c(c1)[C@]1(COC(N)=N1)c1cc(-c3cncnc3)ccc1O2 CHEMBL3354688 IC50 15.0 nM
COc1cnc(C(=O)Nc2ccc(F)c([C@]3(C)CO[C@@](C)(C(F)(F)F)C(N)=N3)n2)c(C)c1 CHEMBL3670366 IC50 15.0 nM
COc1ccc(C(=S)Nc2cc(F)c(F)c([C@]3(C)CS(=O)(=O)N(C)C(=N)N3)c2)nc1 CHEMBL3965084 Ki 15.0 nM
C[C@]1(c2cc(/C=C(\F)c3ccc(C#N)cn3)ccc2F)N=C(N)S[C@@]2(C(=O)N3CCC3)C[C@H]21 CHEMBL4790308 IC50 15.0 nM
C[C@@]1(c2cc(NC(=O)c3ccc(C#N)cc3)ccc2F)Cn2cnc(C(F)F)c2C(N)=N1 CHEMBL4525240 IC50 15.8 nM
COc1nc(N2C[C@@H]3[C@](c4ccccc4)(C2)NC(=N)N(C)S3(=O)=O)nc(C)c1F CHEMBL4107098 Ki 16.0 nM
CO[C@H](C)C(=O)Nc1ccc(F)c([C@]23COC[C@H]2S(=O)(=O)C(C)(C)C(=N)N3)c1 CHEMBL4106945 Ki 16.0 nM
CN1C(=N)N[C@](C)(c2sc(-c3cncc(-c4cnco4)c3)cc2F)CS1(=O)=O CHEMBL3891551 Ki 16.0 nM
CN1C(=N)N[C@](C)(c2sc3c(-c4ccc(-n5cccn5)nc4)nccc3c2Cl)CS1(=O)=O CHEMBL3895439 Ki 16.0 nM
COc1ccc(C(=O)Nc2ccc(F)c([C@]3(C)CS(=O)(=O)C4(CNC4)C(=N)N3)c2)nc1 CHEMBL3891454 Ki 16.0 nM
Cc1cnc(C(=O)Nc2ccc(F)c([C@]34CCC[C@H]3S(=O)(=O)N(C)C(=N)N4)c2)cn1 CHEMBL4126480 Ki 16.0 nM
C[C@@]1(S(C)(=O)=O)CC[C@@](CF)(c2cc(NC(=O)c3cnc(OCF)cn3)ccc2F)N=C1N CHEMBL5081571 IC50 16.0 nM
C[C@H]1SC(N)=N[C@](C)(c2cc(NC(=O)c3ccc(OCF)cn3)ccc2F)[C@H]1F CHEMBL5093159 IC50 16.0 nM
C[C@@]1(S(C)(=O)=O)CC[C@@](CF)(c2cc(NC(=O)c3ccc(OCF)cn3)ccc2F)N=C1N CHEMBL4565391 IC50 16.6 nM
CN1C(=N)N[C@](C)(c2sc(-c3nnc(-c4ccc(Cl)cc4F)o3)cc2Cl)CS1(=O)=O CHEMBL3907865 Ki 16.77 nM
CN1C(=N)N[C@](C)(c2sc(-c3ccnc(-c4nc(C5CC5)no4)c3)cc2F)CS1(=O)=O CHEMBL3893399 Ki 17.0 nM
CN1C(N)=N[C@](C)(c2cc(NC(=O)c3ccc(C#N)cn3)ccc2F)C2(CC2)S1(=O)=O CHEMBL4474110 Ki 17.0 nM
C[C@@]1(c2cc(NC(=O)c3ncc(OC(F)F)cc3Cl)ccc2F)CO[C@@](C)(C(F)(F)F)C(N)=N1 CHEMBL5074449 IC50 17.0 nM
CN1C(=N)N[C@@]2(c3cc(NC(=O)c4cnc(C(F)F)cn4)ccc3F)COC[C@H]2S1(=O)=O CHEMBL3261056 Ki 17.4 nM
CC(F)(F)[C@H]1OC[C@]2(c3cc(NC(=O)c4ccc(C#N)cn4)ccc3F)N=C(N)SC[C@H]12 CHEMBL4564324 IC50 17.6 nM
CC(C)CCn1cc(C2(c3cccc(-c4cccnc4F)c3)N=C(N)N(C)C2=O)cn1 CHEMBL1824341 IC50 18.0 nM
C[C@]1(c2cc(NC(=O)c3ccn(C(F)F)n3)ccc2F)N=C(N)OCC1(F)F CHEMBL2347201 IC50 18.0 nM
CC1(c2cccc(Nc3cccc4cc(Cl)cnc34)c2)COCC(N)=N1 CHEMBL3986044 IC50 18.0 nM
CC1(C)C(=N)N[C@@]2(c3cc(NC(=O)c4cnc(OCCF)cn4)ccc3F)COC[C@H]2S1(=O)=O CHEMBL4112989 Ki 18.0 nM
CN1C(=N)N[C@](C)(c2cc(-c3cc(F)cc(-c4cnco4)c3)cs2)CS1(=O)=O CHEMBL3937535 Ki 18.0 nM
COc1cnc(C(=S)Nc2cc(F)c(F)c([C@]3(C)CS(=O)(=O)N(C)C(=N)N3)c2)cn1 CHEMBL3895521 Ki 18.0 nM
CC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)[C@@H](O)C[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(N)=O)C(C)C CHEMBL3589001 Ki(app) 18.3 nM
C#CCOc1cnc(C(=O)Nc2cc(F)c(F)c([C@@]3(C)N=C(N)S[C@@]4(COC)C[C@H]43)c2)cn1 CHEMBL4560579 IC50 18.6 nM
C#CCOc1cnc(C(=O)Nc2cc(F)c(F)c([C@@]3(C)N=C(N)S[C@@]4(COC)CC43)c2)cn1 CHEMBL5093088 IC50 18.6 nM
COc1nc(N2C[C@@H]3[C@](c4cc(F)c(F)cc4F)(C2)NC(=N)N(C)S3(=O)=O)nc(C)c1F CHEMBL4112392 Ki 19.0 nM
CN1C(=N)N[C@](C)(c2sc3c(-c4ccc(-c5cnco5)cc4F)nccc3c2Cl)CS1(=O)=O CHEMBL3977064 Ki 19.0 nM
C[C@@]1(c2cc(NC(=O)c3ccc(C#N)cn3)ccc2F)Cn2cncc2C(N)=N1 CHEMBL4557890 pIC50 19.05 nM
CN1C(=N)N[C@@]2(c3cc(NC(=O)c4ccc(C(F)(F)F)cn4)ccc3F)COC[C@H]2S1(=O)=O CHEMBL4113989 Ki 19.5 nM
Cn1cc2n(c1=O)C[C@@](C)(c1cc(NC(=O)c3ccc(C#N)cn3)ccc1F)N=C2N CHEMBL4473230 IC50 19.5 nM
CCCC(O)C(NCC(O)C(Cc1ccccc1)NC(=O)c1cc(C)cc(C(=O)N2CCCC2OC)c1)C(=O)NCC(C)C CHEMBL3664021 Ki 19.7 nM
COC[C@H]1CCCN1C(=O)c1cc(C)cc(C(=O)N[C@@H](Cc2cc(F)cc(F)c2)[C@H](O)[C@H]2C[C@@H](Oc3ccccc3)CN2)c1 CHEMBL403195 IC50 20.0 nM
CN1C(=O)C(c2cccc(NC(=O)c3ccco3)c2)(C2CCCCC2)N=C1N CHEMBL590829 IC50 20.0 nM
COc1cccc(-c2cccc(C3(c4ccncc4)N=C(N)N(C)C3=O)c2)c1 CHEMBL1092124 IC50 20.0 nM
CC(C)CCn1cc(C2(c3cccc(-c4cncnc4)c3)N=C(N)N(C)C2=O)cn1 CHEMBL1824139 IC50 20.0 nM
CN1C(=O)C(c2cccc(-c3cncnc3)c2)(c2cnn(CCC3CCCCC3)c2)N=C1N CHEMBL1824143 IC50 20.0 nM
CN1C(=O)C(c2cccc(-c3cccnc3F)c2)(c2cnn(CCC(C)(C)C)c2)N=C1N CHEMBL1824342 IC50 20.0 nM
COc1cncc(-c2cccc(C3(c4ccsc4)N=C(N)N(C)C3=O)c2)c1 CHEMBL1824358 IC50 20.0 nM
Cc1cc(C(=O)Nc2ccc(F)c([C@@]3(C)N=C(N)OC[C@@H]3F)c2)c(C)o1 CHEMBL3680870 IC50 20.0 nM
Cc1cc(C#N)cnc1C(=O)Nc1cccc([C@]2(C)CO[C@@](C)(C(F)(F)F)C(N)=N2)n1 CHEMBL3670353 IC50 20.0 nM
COC[C@@H](C)NCc1ccc(F)c([C@]23CO[C@@H](c4cnn(C)c4)C[C@H]2CSC(N)=N3)c1 CHEMBL3673204 IC50 20.0 nM
CN1C(=N)N[C@](C)(c2sc(-c3ccnc(-c4cnco4)c3)cc2F)CS1(=O)=O CHEMBL3915583 Ki 20.0 nM
C[C@H]1C[C@H]2CSC(N)=N[C@@]2(c2nc(NC(=O)c3ccc(Cl)cn3)cs2)CO1 CHEMBL3967984 IC50 20.0 nM
C[C@]1(c2cc(NC(=O)c3ccc(C#N)cn3)ccc2F)N=C(N)OC[C@@H]1F CHEMBL2347204 IC50 21.0 nM
COc1ccc(Cl)cc1Nc1ccc(F)c([C@@]2(C)N=C(N)N(C)C(=O)C2(C)C)c1 CHEMBL3649705 IC50 21.0 nM
CCc1nc(N2CC3C(c4ccccc4)(C2)NC(=N)N(C)S3(=O)=O)nc(OC)c1F CHEMBL3970188 Ki 21.0 nM
CN1C(=N)N[C@](C)(c2cc(NC(=S)c3ccc(C(F)(F)F)cn3)cc(F)c2F)CS1(=O)=O CHEMBL3923516 Ki 21.0 nM
[2H]C1([2H])OC(N)=N[C@]12c1cc(-c3cc(Cl)cc(C#N)c3)ccc1C[C@]21CC[C@@H](OC)CC1 CHEMBL4062699 Ki 21.0 nM
C[C@@]1(c2cc(NC(=O)c3ccc(C#N)cn3)ccc2F)CCSC(N)=N1 CHEMBL4535964 IC50 21.0 nM
CCCN(CCC)C(=O)c1cc(C)cc(C(=O)N[C@@H](Cc2cc(F)cc(F)c2)[C@H](O)[C@@H]2NCCN(Cc3ccccc3)C2=O)c1 CHEMBL509210 IC50 22.0 nM
CC(=O)N[C@@H](Cc1ccccc1)[C@H](O)CN[C@H]1CC(C)(C)Cc2nn(CC(C)C)cc21 CHEMBL2158257 IC50 22.0 nM
C[C@]1(c2cc(NC(=O)c3ccc(F)cn3)ccc2F)N=C(N)OCC1(F)F CHEMBL2347214 IC50 22.0 nM
CN1C(=N)N[C@](C)(c2sc3c(-c4ccc(C5CC5)nc4)nccc3c2Cl)CS1(=O)=O CHEMBL3917252 Ki 22.0 nM
C[C@@H]1C[C@H]1CNC(=O)[C@@H]1C[C@H]1[C@]12CN(c3ncccn3)C[C@H]1CSC(N)=N2 CHEMBL4643727 IC50 22.0 nM
C[C@]1(c2cc(NC(=O)c3ncc(Cl)cn3)ccc2F)N=C(N)OCC1(F)F CHEMBL2347194 IC50 23.0 nM
C[C@]1(F)COC(N)=N[C@]1(C)c1cc(NC(=O)c2ccc(C#N)cn2)ccc1F CHEMBL3680889 IC50 23.0 nM
C[C@]1(c2cc(NC(=O)c3cnc(C(F)F)cn3)ccc2F)N=C(N)OC[C@@H]1F CHEMBL3680867 IC50 23.0 nM
CN1C(=N)N[C@](C)(c2sc3c(-c4cnc(C5CC5)nc4)nccc3c2Cl)CS1(=O)=O CHEMBL3962552 Ki 23.0 nM
CNS1(O)C[C@@](C)(c2cc(NC(=O)COC)ccc2F)NC(=N)N1C CHEMBL3906268 Ki 23.0 nM
COc1cnc(C(=O)Nc2ccc(F)c([C@]3(C)CS(=O)(=O)C4(CCN(C)CC4)C(=N)N3)c2)c(C)c1 CHEMBL3934446 Ki 23.0 nM
COc1cnc(C(=O)Nc2ccc(F)c([C@]3(C)CS(=O)(=O)C4(CCN(C)CO4)C(=N)N3)c2)c(C)n1 CHEMBL3933963 Ki 23.0 nM
C[C@]1(c2cc(NC(=O)c3ccc(C#N)cn3)ccc2F)N=C(N)OCC1(F)F CHEMBL2347215 IC50 24.0 nM
C[C@]1(c2cc(NC3CCc4cc(Cl)cnc43)ccc2F)N=C(N)COC[C@@H]1F CHEMBL3670904 IC50 24.0 nM
Cc1cc(OC(F)F)cnc1C(=O)Nc1ccc(F)c([C@]2(C)CO[C@@](C)(C(F)(F)F)C(N)=N2)n1 CHEMBL3670370 IC50 24.0 nM
C[C@@]1(c2nc(NC(=O)c3ncc(OC(F)F)cc3Cl)ccc2F)CO[C@@](C)(C(F)(F)F)C(N)=N1 CHEMBL3670371 IC50 24.0 nM
Cc1cc(C(=O)Nc2ccc(F)c([C@]34COC[C@H]3S(=O)(=O)C(C)(C)C(=N)N4)c2)no1 CHEMBL4110452 Ki 24.0 nM
COc1ccc(C(=O)Nc2ccc(F)c([C@]3(C)CS(=O)(=O)C4(CCN(C)CC4)C(=N)N3)c2)nc1 CHEMBL3986242 Ki 24.0 nM
Cc1cc(C#N)cnc1C(=O)Nc1ccc(F)c([C@]2(C)CS(=O)(=O)C3(CCN(C)CC3)C(=N)N2)c1 CHEMBL3934413 Ki 24.0 nM
C[C@@]1(c2cc(NC(=O)c3ccc(C#N)cn3)ccc2F)Cn2cccc2C(N)=N1 CHEMBL3261075 pIC50 25.12 nM
COc1cccc(N2CC3C(c4ccccc4)(C2)NC(=N)N(C)S3(=O)=O)n1 CHEMBL3964022 Ki 26.0 nM
Cc1cn(-c2cc(-c3cc(F)c([C@]4(C)CS(=O)(=O)N(C)C(=N)N4)s3)ccn2)cn1 CHEMBL3913815 Ki 26.0 nM
C[C@@]1(c2cccc(NC(=O)c3ccc(C#N)cn3)c2)Cn2nccc2C(N)=N1 CHEMBL4521954 pIC50 26.3 nM
C[C@@]1(c2cc(NC(=O)c3ccc(C#N)cn3)ccc2F)Cn2nnnc2C(N)=N1 CHEMBL4446937 pIC50 26.92 nM
C[C@]1(c2nc(NC(=O)c3ncc(OCF)cc3Cl)ccc2F)N=C(N)OCC1(F)F CHEMBL4111699 IC50 27.0 nM
COc1cccnc1Nc1ccc(F)c([C@]2(C)CO[C@@](C)(C(F)(F)F)C(N)=N2)c1 CHEMBL3897635 IC50 27.0 nM
CN1C(=N)N[C@](C)(c2sc3c(-c4ccc(-c5ccnn5C)cc4F)nccc3c2Cl)CS1(=O)=O CHEMBL3911285 Ki 27.0 nM
CN1CCC2(CC1)C(=N)N[C@](C)(c1cc(NC(=O)c3ccc(OC(F)F)cn3)ccc1F)CS2(=O)=O CHEMBL3943424 Ki 27.0 nM
CN1C(=N)N[C@](C)(c2sc(-c3cnn(-c4ccccc4)c3)cc2Cl)CS1(=O)=O CHEMBL3914207 Ki 27.87 nM
CCc1cn2c3c(cc(C(=O)N[C@@H](Cc4ccccc4)[C@H](O)CNCCC(F)(F)F)cc13)N(C)S(=O)(=O)CC2 CHEMBL560092 IC50 28.0 nM
CC1(C)OCC(N)=N[C@](C)(c2cc(NC3CCc4cc(Cl)cnc43)ccc2F)C1(F)F CHEMBL3670916 IC50 28.0 nM
CN1C(=N)N[C@](C)(c2cc(NC(=S)C(F)F)cc(F)c2F)CS1(=O)=O CHEMBL3956060 Ki 28.0 nM
C[C@]1(c2cc(NC(=O)c3cnc(OCF)cn3)ccc2F)N=C(N)SC[C@@H]1c1ccccc1 CHEMBL4473080 IC50 28.0 nM
O=C([C@@H]1CNC[C@]12CCCc1nc(Cl)ccc12)N1CC[C@@H](c2ccccc2)C[C@H]1C1CCCCC1 CHEMBL1934295 IC50 29.0 nM
COc1cnc(C(=O)Nc2ccc(F)c([C@]3(C)CS(=O)(=O)C4(CCN(C)CC4)C(=N)N3)c2)cn1 CHEMBL3911062 Ki 29.0 nM
C[C@@H](F)[C@H]1OC(N)=N[C@](C)(c2cc(NC(=O)c3cnc(OCF)cn3)ccc2F)[C@H]1F CHEMBL4226007 IC50 29.9 nM
Cc1ccoc1C(=O)Nc1cccc(C2(C3CCCCC3)N=C(N)N(C)C2=O)c1 CHEMBL590830 IC50 30.0 nM
CN1C(=O)C(c2cccc(-c3cncnc3)c2)(c2cnn(CCC(C)(C)C)c2)N=C1N CHEMBL1824140 IC50 30.0 nM
CN1C(=N)NC(c2cccc(-c3cccc(C#N)c3)c2)(C2CC2)C1=O CHEMBL2012002 Ki 30.0 nM
CC#Cc1cncc(-c2cccc(C3(C4CC4)N=C(C)C(N)=N3)c2)c1 CHEMBL2180037 IC50 30.0 nM
Cc1ccc(C(=O)Nc2ccc(F)c([C@@]3(C)N=C(N)OCC3(F)F)c2)nc1 CHEMBL2347363 IC50 30.0 nM
CCCC(O)N(NC[C@H](Cc1ccccc1)NC(=O)c1cc2c3c(c1)c(CC)cn3CC1(CC1)S(=O)(=O)N2C)C(=O)NC(C)C CHEMBL3664016 Ki 30.0 nM
C[C@]1(c2cc(N[C@H]3CCc4cc(Cl)cnc43)ccc2F)N=C(N)COCC1(F)F CHEMBL3670911 IC50 30.0 nM
C[C@@]1(c2nc(NC(=O)c3ncc(C(F)(F)F)cc3Cl)ccc2F)CO[C@@](C)(C(F)(F)F)C(N)=N1 CHEMBL3670375 IC50 30.0 nM
N#Cc1cnc2c(Nc3ccc(F)c([C@]4(C(F)F)COCC(N)=N4)c3)nccc2c1 CHEMBL3898813 IC50 30.0 nM
CN1C(=N)N[C@](C)(c2sc(-c3cccc(-c4nnco4)c3F)cc2Cl)CS1(=O)=O CHEMBL3969459 Ki 30.0 nM
CN1C(=N)N[C@](C)(c2sc3c(-c4ccc(-c5ccn[nH]5)cc4)nccc3c2Cl)CS1(=O)=O CHEMBL3894568 Ki 30.0 nM
CC#CCOc1ccc(C(=O)Nc2ccc(F)c([C@]3(C)CS(=O)(=O)C4(CN(C)C4)C(=N)N3)c2)nc1 CHEMBL3923725 Ki 30.0 nM
CC#CCOc1ccc(C(=O)Nc2ccc(F)c([C@]3(C)CS(=O)(=O)C4(CCN(C)CC4)C(=N)N3)c2)nc1 CHEMBL3939487 Ki 30.0 nM
CC(C)C[C@H](NC(=O)c1cc(C(=O)N[C@H](C)c2ccccc2)cc(N(C)S(C)(=O)=O)c1)[C@@H](O)C[C@@H](C)C(=O)N[C@H](C(=O)NC(C)C)C(C)C CHEMBL387771 Ki 31.0 nM
Cn1cc(Cl)c(C(=O)Nc2ccc(F)c([C@@]3(C)N=C(N)OCC3(F)F)c2)n1 CHEMBL2347200 IC50 31.0 nM
C[C@]1(F)COC(N)=N[C@]1(C)c1cc(NC(=O)c2nn(C(F)F)cc2Cl)ccc1F CHEMBL3680891 IC50 31.0 nM
CN1C(=N)N[C@](C)(c2sc3c(-c4ccc(-n5cccn5)nc4)cccc3c2F)CS1(=O)=O CHEMBL3901303 Ki 31.0 nM
C#CCOc1cnc(C(=O)Nc2cc(F)c(F)c([C@@]3(C)N=C(N)S[C@@]4(COC)C[C@H]43)c2)c(C)c1 CHEMBL4452318 IC50 31.0 nM
C[C@]1(c2cc(/C=C(\F)c3ccc(C#N)cn3)ccc2F)N=C(N)S[C@@]2(S(C)(=O)=O)C[C@H]21 CHEMBL4779386 IC50 31.0 nM
CN1C(=N)N[C@](C)(c2sc(-c3nnc(-c4ncco4)o3)cc2Cl)CS1(=O)=O CHEMBL3954987 Ki 31.68 nM
NC1=N[C@@](c2cc(Nc3ncnc4cc(Cl)cnc34)ccc2F)(C(F)F)COC1 CHEMBL3890696 IC50 32.0 nM
CN1C[C@@H](c2cc(NC(=O)c3ccc(C#N)cn3)ccc2F)N=C(N)C(C)(C)S1(=O)=O CHEMBL4525546 Ki 32.0 nM
CC1(C)C(=N)N[C@@]2(c3cc(NC(=O)C(F)F)ccc3F)COC[C@H]2S1(=O)=O CHEMBL4113002 Ki 33.0 nM
COC[C@]12C[C@H]1[C@@](C)(c1cc(NC(=O)c3cnc(OCc4ncco4)cn3)cc(F)c1F)N=C(N)S2 CHEMBL4459222 IC50 34.0 nM
COc1ccc(-c2nnc(-c3cc(Cl)c([C@]4(C)CS(=O)(=O)N(C)C(=N)N4)s3)o2)cc1 CHEMBL3952594 Ki 34.61 nM
C[C@]1(c2cc(NCc3nn(C(F)F)cc3Cl)ccc2F)N=C(N)COC[C@@H]1F CHEMBL3670905 IC50 35.0 nM
C[C@]1(c2cc(NC(=O)c3[nH]ncc3Cl)ccc2F)N=C(N)OC[C@@H]1F CHEMBL3680880 IC50 35.0 nM
COc1cc(Cl)c(C)cc1Nc1ccc(F)c([C@@]2(C)N=C(N)N(C)C(=O)C2(C)C)c1 CHEMBL3649708 IC50 35.0 nM
CC1(C)C(=N)N[C@@]2(c3cc(NC(=O)c4cnc(C(F)(F)F)cn4)ccc3F)COC[C@H]2S1(=O)=O CHEMBL4110744 Ki 35.0 nM
CCCc1cnn(-c2ccc(-c3nccc4c(Cl)c([C@]5(C)CS(=O)(=O)N(C)C(=N)N5)sc34)c(F)c2)c1 CHEMBL3984093 Ki 35.0 nM
CC1CN=C(c2ccc(-c3cc(Cl)c([C@]4(C)CS(=O)(=O)N(C)C(=N)N4)s3)[nH]2)O1 CHEMBL3932113 Ki 35.0 nM
CCC(CC)Cn1cc(C2(c3cccc(-c4cccnc4F)c3)N=C(N)N(C)C2=O)cn1 CHEMBL1824343 IC50 36.0 nM
C[C@]1(c2cc(NC(=O)c3ccccn3)ccc2F)N=C(N)OCC1(F)F CHEMBL2347213 IC50 36.0 nM
CN1C(=N)N[C@](C)(c2sc3c(-c4ccc(-n5ccnn5)cc4)nccc3c2Cl)CS1(=O)=O CHEMBL3954775 Ki 36.0 nM
CC(C)CNC(=O)C(NCC(O)C(Cc1ccccc1)NC(=O)c1cc(C(=O)NC(C)c2ccccc2)cc(N(C)S(C)(=O)=O)c1)C(C)O CHEMBL3704769 Ki 37.0 nM
C[C@@]1(c2cc(NC(=O)c3ccc(C#N)cn3)ccc2F)Cn2ncnc2C(N)=N1 CHEMBL4438397 pIC50 37.15 nM
Cc1cc(F)cnc1C(=O)Nc1csc([C@]23CO[C@@H](C)C[C@H]2CSC(N)=N3)n1 CHEMBL3983988 IC50 38.9 nM
CN1C(=O)C(C)(C)[C@@](C)(c2cc(Nc3cc(C#N)ccc3F)ccc2F)N=C1N CHEMBL3649693 IC50 39.0 nM
C#CCOc1cnc(C(=O)Nc2cc(F)c(F)c([C@@]3(CF)N=C(N)S[C@H]4C[C@H]43)c2)cn1 CHEMBL4454250 IC50 39.4 nM
COCC(=O)Nc1cccc(C2(C3CCCCC3)N=C(N)N(C)C2=O)c1 CHEMBL589614 IC50 40.0 nM
CN1C(=O)C(c2ccncc2)(c2cccc(-c3cccc(C#N)c3)c2)N=C1N CHEMBL1092475 IC50 40.0 nM
CC(C)C#Cc1cccc([C@@]2(c3ccc(OC(F)F)cc3)N=C(N)N(C)C2=O)c1 CHEMBL1271245 IC50 40.0 nM
C#CCOc1ccc(C(=O)Nc2cc(F)c(F)c([C@@]3(C)N=C(N)S[C@@]4(COC)C[C@H]43)c2)nc1 CHEMBL4456778 IC50 40.0 nM
COC[C@]12C[C@H]1[C@@](C)(c1cc(NC(=O)c3cnc(OCC(F)(F)F)cn3)cc(F)c1F)N=C(N)S2 CHEMBL4579155 IC50 40.0 nM
C[C@@]1(c2cccc(NC(=O)c3ncc(C#N)cc3Cl)n2)CO[C@@](C)(C(F)(F)F)C(N)=N1 CHEMBL3670362 IC50 41.0 nM
CS(=O)(=O)N(c1ccccc1)c1cc(C(=O)N[C@@H](Cc2ccccc2)[C@H](O)CNCc2cccc(C(F)(F)F)c2)cc(C2CCCC2)c1 CHEMBL1210434 IC50 42.0 nM
CO[C@@H](C)C(=O)Nc1ccc(F)c([C@]23COC[C@H]2S(=O)(=O)C(C)(C)C(=N)N3)c1 CHEMBL3928892 Ki 42.0 nM
CN1C(=N)N[C@](C)(c2sc(-c3cccc(N4CCS(=O)(=O)CC4)c3)cc2Cl)CS1(=O)=O CHEMBL3920356 Ki 42.0 nM
COC[C@]12C[C@H]1[C@@](CF)(c1cc(/C=C(\F)c3ccc(Cl)cn3)ccc1F)N=C(N)S2 CHEMBL4749943 IC50 42.0 nM
COc1ncc(Cc2c(C)noc2C)c2c1C[C@]1(c3ccc(F)cc3F)N=C(N)SC[C@@H]1C2 CHEMBL4520734 pIC50 43.65 nM
CN1C(=N)N[C@](C)(c2sc(-c3cncc(-c4nnc(C5CC5)o4)c3)cc2Cl)CS1(=O)=O CHEMBL3943544 Ki 44.0 nM
CCCCNC(=O)[C@@H]1C[C@H]1[C@]12CN(c3ncccn3)C[C@H]1CSC(N)=N2 CHEMBL4636286 IC50 44.0 nM
CC(F)(F)[C@H]1OC(N)=N[C@](C)(c2cc(NC(=O)c3cnc(OCF)cn3)ccc2F)[C@H]1F CHEMBL4226994 IC50 44.1 nM
CN1C(=N)N[C@](C)(c2sc(-c3nnc(-c4nccs4)o3)cc2Cl)CS1(=O)=O CHEMBL3950717 Ki 44.29 nM
CN1C(=N)N[C@](C)(c2sc(-c3nnc(-c4ccc(C#N)cc4)o3)cc2Cl)CS1(=O)=O CHEMBL3956094 Ki 44.92 nM
CCCN(CCC)C(=O)c1cc(C)cc(C(=O)N[C@@H](Cc2cc(F)cc(F)c2)[C@H](O)[C@H]2C[C@@H](OCc3ccccc3)CN2)c1 CHEMBL270359 IC50 45.0 nM
COc1ccc(C(=O)Nc2ccc(F)c([C@@]3(C)N=C(N)OCC3(F)F)c2)nc1 CHEMBL2347365 IC50 45.0 nM
C[C@]1(c2cc(/C=C(\F)c3ccc(C#N)cn3)ccc2F)N=C(N)S[C@@]2(C(=O)N3CCCCC3)C[C@H]21 CHEMBL4746645 IC50 45.0 nM
CSC[C@H](NC(=O)C1NOC2OCCC21)C(=O)NC(CC(C)C)[C@@H](O)CC(C)C(=O)NC(C(=O)N(C)C)C(C)C CHEMBL3704762 Ki 46.0 nM
C#Cc1ccc(C(=O)Nc2ccc(F)c([C@@]3(C)N=C(N)OCC3(F)F)c2)nc1 CHEMBL2347364 IC50 47.0 nM
C[C@@]1(S(C)(=O)=O)CC[C@@](CF)(c2cc(NC(=O)c3cc4c(cn3)OCO4)ccc2F)N=C1N CHEMBL5084928 IC50 47.0 nM
NC1=Nc2ccc(Oc3ccccc3)cc2CN1C(CCC(=O)N(CC1CCC(=O)N1)C1CCCCC1)C1CCCCC1 CHEMBL3704760 Ki 48.0 nM
C[C@]1(c2nc(NC(=O)c3ncc(Cl)cc3N)ccc2F)N=C(N)OCC1(F)F CHEMBL4115329 IC50 48.0 nM
COc1cnc(C(=O)Nc2ccc(F)c([C@]34COC[C@H]3S(=O)(=O)N(C)C(=N)N4)c2)cn1 CHEMBL4110309 Ki 48.4 nM
Cc1cc([C@]2(c3cccc(C#CC4CC4)c3)N=C(N)N(C)C2=O)ccc1OC(F)F CHEMBL1270630 IC50 50.0 nM
CC(C)Cn1cc(C2(c3cccc(-c4cccnc4F)c3)N=C(N)N(C)C2=O)cn1 CHEMBL1824340 IC50 50.0 nM
CCCCn1cc(C2(c3cccc(-c4cccnc4F)c3)N=C(N)N(C)C2=O)cn1 CHEMBL1824344 IC50 50.0 nM
CCC(=O)c1cc([C@]2(c3cccc(-c4cccnc4F)c3)N=C(N)N(C)C2=O)cs1 CHEMBL1824361 IC50 50.0 nM
C[C@]1(c2cc(/C=C(\F)c3ccc(C#N)cn3)ccc2F)N=C(N)S[C@@]2(C(=O)N3CCCC3)C[C@H]21 CHEMBL4740498 IC50 50.0 nM
CCS(=O)(=O)[C@]1(C)CC[C@@](CF)(c2cc(NC(=O)c3cc4c(cn3)OC(F)(F)O4)ccc2F)N=C1N CHEMBL5092328 Ki 50.0 nM
CCCN(CCC)C(=O)c1cc(C)cc(C(=O)N[C@@H](Cc2cc(F)cc(F)c2)[C@H](O)[C@@H]2NCN(Cc3ccccc3)C2=O)c1 CHEMBL507651 IC50 51.0 nM
C#CCOc1cnc(/C(F)=C/c2ccc(F)c([C@]3(C)CS(=O)(=O)C(C)(C)C(N)=N3)c2)cn1 CHEMBL4470897 IC50 51.0 nM
CN1C(N)=N[C@@]2(CCOc3ccc(NC(=O)c4ccc(C#N)cn4)cc32)CS1(=O)=O CHEMBL4520547 Ki 51.0 nM
C[C@@]1(c2cc(NC(=O)c3ccc(Cl)cn3)ccc2F)CCOC(N)=N1 CHEMBL2347209 IC50 52.0 nM
CN1C(=N)N[C@](C)(c2cc(-c3cccc(-c4nnco4)c3)cs2)CS1(=O)=O CHEMBL3983929 Ki 52.0 nM
CN1C(=N)N[C@](C)(c2sc(-c3ccnc(-n4ccnc4)c3)cc2F)CS1(=O)=O CHEMBL3934800 Ki 52.0 nM
CN1CCC2(CC1)C(=N)N[C@](C)(c1cc(NC(=O)c3ccc(OC(F)(F)F)cn3)ccc1F)CS2(=O)=O CHEMBL3972967 Ki 52.0 nM
C#CCOc1cnc(/C(F)=C/c2ccc(F)c([C@]3(C)CS(=O)(=O)N(C)C(N)=N3)c2)cn1 CHEMBL4440849 IC50 52.0 nM
CN1C(=N)N[C@](C)(c2cc(-c3cc(-c4ccccc4)on3)ccc2F)CS1(=O)=O CHEMBL3938450 Ki 52.64 nM
Cc1ncsc1CN(C(=O)CCC(C1CCCCC1)N1Cc2cc(Oc3ccccc3)ccc2N=C1N)C1CCCCC1 CHEMBL3704765 Ki 53.0 nM
CC(C)CC(NC(=O)[C@H](CS(C)(=O)=O)NC(=O)C1NOC2OCCC21)[C@@H](O)CC(C)C(=O)NC(C(=O)N(C)C)C(C)C CHEMBL3704764 Ki 53.0 nM
CCCN(CCC)C(=O)c1cc(C)cc(C(=O)N[C@@H](Cc2cc(F)cc(F)c2)[C@H](O)[C@H]2C[C@@H](Oc3ccccc3)CN2)c1 CHEMBL403727 IC50 54.0 nM
Cc1cc(C#N)cnc1C(=O)Nc1cc([C@]2(C)CO[C@@](C)(C(F)(F)F)C(N)=N2)c(F)cn1 CHEMBL3261068 IC50 55.0 nM
CN1C(=N)N[C@@]2(c3cc(NC(=O)c4cnc(C(F)(F)F)cn4)ccc3F)COC[C@H]2S1(=O)=O CHEMBL4115284 Ki 55.0 nM
CN1C(=N)N[C@]2(c3cc(NC(=O)c4ccc(Cl)cn4)ccc3F)COC[C@@H]2S1(=O)=O CHEMBL3924242 Ki 55.2 nM
COCC(=O)Nc1ccc(F)c([C@]2(C)CS(=O)(=O)C3(CCN(C)CC3)C(=N)N2)c1 CHEMBL3977613 Ki 56.0 nM
C[C@@]1(c2cc(NC(=O)c3ccc(C#N)cn3)ccc2F)Cn2cnnc2C(N)=N1 CHEMBL4473647 pIC50 56.23 nM
COc1nc(N2CC3C(c4ccccc4)(C2)NC(=N)N(C)S3(=O)=O)nc(C)c1F CHEMBL3924782 Ki 57.0 nM
Cc1cc(OC(F)F)cnc1C(=O)Nc1csc([C@]23CO[C@@H](C)C[C@H]2CSC(N)=N3)n1 CHEMBL3972449 IC50 57.0 nM
CC1(C)OCC(N)=N[C@](C)(c2cc(NC3COc4cc(Cl)cnc43)ccc2F)C1(F)F CHEMBL3670917 IC50 58.0 nM
CO/N=C(/Nc1ccc(F)c([C@]2(C)CS(=O)(=O)N(C)C(=N)N2)c1)c1ccc(Cl)cn1 CHEMBL3972470 Ki 58.0 nM
CN1C(=N)N[C@](C)(c2sc(-c3nnc(-c4ccccn4)o3)cc2Cl)CS1(=O)=O CHEMBL3904873 Ki 58.41 nM
CCc1cn2c3c(cc(C(=O)N[C@@H](Cc4ccccc4)[C@H](O)CNCc4cccc(C(F)(F)F)c4)cc13)N(C)S(=O)(=O)CC2 CHEMBL446972 IC50 59.0 nM
CCc1cn2c3c(cc(C(=O)N[C@@H](Cc4ccccc4)[C@H](O)CNCc4cccc(C(F)(F)F)c4)cc13)N(C)S(=O)(=O)CC2 CHEMBL554349 IC50 59.0 nM
CN1C(=O)C(c2ccncc2)(c2cccc(-c3cc(F)cc(F)c3)c2)N=C1N CHEMBL1091463 IC50 60.0 nM
C[C@H]1C[C@H]2CSC(N)=N[C@@]2(c2nc(NC(=O)c3ccc(C#N)cn3)cs2)CO1 CHEMBL4211913 IC50 60.7 nM
C[C@]1(c2cc(NC(=O)c3ccc(Cl)cn3)ccc2F)N=C(N)OC[C@@H]1OCC(F)(F)F CHEMBL3680895 IC50 61.0 nM
CN1C(=N)N[C@](C)(c2sc3c(-c4ccc(-c5ccc(F)cc5F)nc4)cccc3c2F)CS1(=O)=O CHEMBL3948490 Ki 61.0 nM
CN1C(=O)C(C)(C)C(C)(c2cc(Nc3ccc(C#N)cc3C(F)(F)F)ccc2F)N=C1N CHEMBL3649691 IC50 62.0 nM
CC(C)CNC(=O)C(NCC(O)C(Cc1ccccc1)NC(=O)c1cccc(C(=O)N(C)C(C)c2ccccc2)c1)C(C)O CHEMBL3664018 Ki 63.1 nM
CN1C(=N)N[C@](C)(c2sc3c(-c4cnc(-n5cccn5)nc4)nccc3c2Cl)CS1(=O)=O CHEMBL3945940 Ki 64.0 nM
C[C@]1(c2cc(NC(=O)c3ccc(F)cn3)ccc2F)N=C(N)OC[C@@H]1OCC(F)(F)F CHEMBL3680896 IC50 65.0 nM
COc1ccc(C(=O)Nc2ccc(F)c([C@@]3(C)N=C(N)OC[C@@H]3F)c2)nc1 CHEMBL3680865 IC50 65.0 nM
C[C@]1(c2nc(NC(=O)c3ccc(C#N)cn3)ccc2F)N=C(N)OCC1(F)F CHEMBL2386719 IC50 66.0 nM
Cc1cc(C#N)cnc1C(=O)Nc1ccc(F)c([C@@]2(C)N=C(N)OCC2(F)F)n1 CHEMBL4114267 IC50 66.0 nM
CN1C(=N)N[C@](C)(c2sc(-c3cc(-c4nnco4)ncc3F)cc2Cl)CS1(=O)=O CHEMBL3935818 Ki 66.0 nM
COc1ccc(C(=O)Nc2ccc(F)c([C@]3(C)CC[C@@](C)(C#N)C(N)=N3)c2)nc1 CHEMBL4556248 IC50 66.0 nM
C[C@@]1(S(C)(=O)=O)CC[C@@](CF)(c2cc(NC(=O)c3cc4c(cn3)OC(F)(F)CO4)ccc2F)N=C1N CHEMBL5091877 IC50 66.0 nM
C[C@]1(c2cc(NC(=O)c3ncc(Cl)cc3Cl)ccc2F)N=C(N)OC[C@@H]1OCC(F)(F)F CHEMBL3680898 IC50 67.0 nM
CS(=O)(=O)N(c1ccccc1)c1cc(C(=O)N[C@@H](Cc2ccccc2)[C@H](O)CNCc2cccc(C(F)(F)F)c2)cc(-c2ccccc2)c1 CHEMBL1210362 IC50 68.0 nM
Cc1cncc(-c2cccc(C3(C4CC4)NC(=N)N(C)C3=O)c2)c1 CHEMBL2011964 Ki 68.0 nM
CN1C(=N)N[C@](C)(c2sc3c(-c4ccc(-n5cccn5)cc4)cccc3c2F)CS1(=O)=O CHEMBL3934761 Ki 68.0 nM
C[C@@H](NC(=O)c1cc(C(=O)N[C@@H](Cc2ccccc2)[C@H](O)CNC2CC2)cc(N(C)S(C)(=O)=O)c1)c1ccc(F)cc1 CHEMBL377625 IC50 69.0 nM
CN1C(=N)N[C@](C)(c2sc(-c3ccnc(-n4cccn4)c3)cc2F)CS1(=O)=O CHEMBL3914820 Ki 69.0 nM
CN1C(=N)N[C@](C)(c2sc(-c3ccc(C4=NCCO4)[nH]3)cc2Cl)CS1(=O)=O CHEMBL3918315 Ki 69.0 nM
CNC(=O)[C@]12C[C@H]1[C@@](C)(c1cc(/C=C(\F)c3ccc(C#N)cn3)ccc1F)N=C(N)S2 CHEMBL4787115 IC50 69.0 nM
CN1C(=N)N[C@](C)(c2sc(-c3nnc(-c4cscn4)o3)cc2Cl)CS1(=O)=O CHEMBL3936219 Ki 69.07 nM
CN1C(=O)[C@@](c2ccc(OC(F)F)cc2)(c2cccc(C#CC3CC3)c2)N=C1N CHEMBL1271246 IC50 70.0 nM
CCC(=O)c1cc(C2(c3cccc(-c4cncnc4)c3)N=C(N)N(C)C2=O)cs1 CHEMBL1824353 IC50 70.0 nM
CCC(=O)c1cc(C2(c3cccc(-c4cccnc4F)c3)N=C(N)N(C)C2=O)cs1 CHEMBL1824360 IC50 70.0 nM
Cc1oncc1CN(C(=O)CCC(C1CCCCC1)N1Cc2cc(Oc3ccccc3)ccc2N=C1N)C1CCCCC1 CHEMBL3704766 Ki 70.0 nM
CC1(C)OC(N)=N[C@](C)(c2nc(NC(=O)c3ncc(C#N)cc3Cl)ccc2F)C1(F)F CHEMBL2386721 IC50 71.0 nM
C[C@]1(c2nc(NC(=O)c3ncc(C#N)cc3Cl)ccc2F)N=C(N)OCC1(F)F CHEMBL2386720 IC50 71.0 nM
Cc1csc(C[C@H](C)C(=O)N[C@@H](CNC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(C)C)[C@@H](O)C[C@@H](C)C(=O)N[C@H](C(=O)NCC(C)C)C(C)C)n1 CHEMBL3352906 Ki 71.0 nM
C[C@]1(c2cc(NC3CCOC3)ccc2F)N=C(N)COC[C@@H]1F CHEMBL3670906 IC50 72.0 nM
Cc1cn2ccnc(Nc3ccc(F)c([C@]4(C(F)F)COCC(N)=N4)c3)c2n1 CHEMBL3914008 IC50 72.0 nM
C[C@]1(c2cc(NC(=O)c3cnc(OCF)cn3)ccc2F)N=C(N)O[C@H](C2(F)CC2)[C@@H]1F CHEMBL4227851 IC50 72.3 nM
C[C@]1(c2cc(NC3CCCOC3)ccc2F)N=C(N)COC[C@@H]1F CHEMBL3670907 IC50 73.0 nM
CN1C(=O)C(C)(C)[C@@](C)(c2cc(Nc3cccc(C#N)c3)ccc2F)N=C1N CHEMBL3649695 IC50 73.0 nM
C[C@]1(F)COC(N)=N[C@]1(C)c1cc(NC(=O)c2ccc(F)cn2)ccc1F CHEMBL3680893 IC50 74.0 nM
C[C@]1(c2cc(NC(=O)c3cnc(OCF)cn3)ccc2F)N=C(N)SC[C@@H]1C1CCOCC1 CHEMBL4587362 IC50 74.0 nM
CCn1cc2c3c(cc(C(=O)N[C@@H](Cc4ccccc4)[C@H](O)CNCCC(F)(F)F)cc31)N(C)S(=O)(=O)CC2 CHEMBL564530 IC50 75.0 nM
CCCC(O)C(NCC(O)C(Cc1ccccc1)NC(=O)c1cccc(C(=O)N2CCCC2OC)c1)C(=O)NCC(C)C CHEMBL3664020 Ki 76.6 nM
C[C@@]1(c2cc(Nc3cccc4cc(Cl)cnc34)ccc2F)COCC(N)=N1 CHEMBL3907448 IC50 77.0 nM
CN1C(=N)N[C@](C)(c2sc(-c3cccc(-n4ccnc4)n3)cc2Cl)CS1(=O)=O CHEMBL3984274 Ki 77.0 nM
CCn1cc([C@]2(c3cccc(C#CC4CC4)c3)N=C(N)c3c(F)cccc32)cc(C)c1=O CHEMBL2177304 Ki 78.0 nM
C[C@@]1(c2cc(NC(=O)c3cnc(OCF)cn3)ccc2F)CCSC(N)=N1 CHEMBL4568202 IC50 78.0 nM
COc1ccc(Cc2cnc(OC)c3c2C[C@H]2CSC(N)=N[C@@]2(c2ccc(F)cc2F)C3)cc1 CHEMBL4526561 pIC50 79.43 nM
CN1C(=O)C(c2ccncc2)(c2cccc(-c3cccc(F)c3)c2)N=C1N CHEMBL1092476 IC50 80.0 nM
CN1C(=O)C(C)(C)[C@@](C)(c2cc(Nc3cc(F)c(C#N)cc3F)ccc2F)N=C1N CHEMBL3649694 IC50 80.0 nM
CN1C(=N)N[C@](C)(c2sc(-c3nnc(-c4ccc(F)c(F)c4)o3)cc2Cl)CS1(=O)=O CHEMBL3916859 Ki 81.32 nM
C[C@@]1(c2cccc(NC(=O)c3ncc(C#N)cc3N)n2)CO[C@@](C)(C(F)(F)F)C(N)=N1 CHEMBL3670361 IC50 82.0 nM
COc1cnc(C(=O)Nc2ccc(F)c([C@]3(C)CCSC(N)=N3)c2)cn1 CHEMBL4561732 IC50 85.0 nM
CN1C(=N)N[C@](C)(c2sc3c(-c4ccc(-c5nccn5C)cc4)nccc3c2Cl)CS1(=O)=O CHEMBL3983409 Ki 86.0 nM
C[C@@]1(c2cc(NC(=O)c3ccc(C#N)cn3)ccc2F)C=C(CF)OC(N)=N1 CHEMBL4213486 IC50 86.3 nM
Cc1occc1-c1ccc(-c2nccc3c(Cl)c([C@]4(C)CS(=O)(=O)N(C)C(=N)N4)sc23)c(F)c1 CHEMBL3947812 Ki 87.0 nM
CN1/C(=N\C(=O)OC(C)(C)C)N[C@](C)(c2sc(-c3ncc(-c4ccccn4)[nH]3)cc2Cl)CS1(=O)=O CHEMBL3895779 Ki 87.92 nM
CC(=O)N[C@@H](Cc1ccccc1)[C@H](O)CNC1CC(C)(C)Cc2nn(CC(C)(C)C)cc21 CHEMBL2158256 IC50 88.0 nM
CCc1cn2c3c(cc(C(=O)N[C@@H](Cc4ccccc4)[C@H](O)CNC4CCCCC4)cc13)N(CC)S(=O)(=O)CC2 CHEMBL558582 IC50 89.0 nM
CC(C)CNC(=O)C(NCC(O)C(Cc1ccccc1)NC(=O)c1cc(C(=O)NC(C)c2ccc(I)cc2)cc(N(C)S(C)(=O)=O)c1)C(C)O CHEMBL3704771 Ki 89.0 nM
COc1cccnc1Nc1ccc(F)c([C@]2(C(F)F)COCC(N)=N2)c1 CHEMBL3951851 IC50 89.0 nM
CN1C(=N)N[C@](C)(c2sc(-c3cc(-c4nnco4)ncc3F)cc2F)CS1(=O)=O CHEMBL3907858 Ki 92.0 nM
COc1cnc(C(=O)Nc2ccc(F)c([C@@]3(C)N=C(N)OCC3(F)F)n2)c(C)c1 CHEMBL4111654 IC50 93.0 nM
Cc1cc(C(=O)Nc2ccc(F)c([C@]34COC[C@H]3S(=O)(=O)C(C)(C)C(=N)N4)c2)on1 CHEMBL4111126 Ki 93.0 nM
CCOc1cnc(C(=O)Nc2cc(F)c(F)c([C@@]3(C)N=C(N)S[C@@]4(COC)C[C@H]43)c2)cn1 CHEMBL4593414 IC50 94.0 nM
CCCOc1cnc(C(=O)Nc2cc(F)c(F)c([C@@]3(C)N=C(N)S[C@@]4(COC)C[C@H]43)c2)cn1 CHEMBL4575413 IC50 94.0 nM
CC1(C)OCC(N)=N[C@](C)(c2cc(N[C@@H]3CCc4cc(C#N)cnc43)ccc2F)C1(F)F CHEMBL3670915 IC50 95.0 nM
C[C@]1(c2nc(NC(=O)c3ncccc3Cl)ccc2F)N=C(N)OCC1(F)F CHEMBL4106556 IC50 95.0 nM
CCc1cn2c3c(cc(C(=O)N[C@@H](Cc4ccccc4)[C@H](O)CNCc4cccc(OC)c4)cc13)N(C)S(=O)(=O)CC2 CHEMBL539436 IC50 96.0 nM
Cc1nonc1N1CCN(c2nccc3c(Cl)c([C@]4(C)CS(=O)(=O)N(C)C(=N)N4)sc23)CC1 CHEMBL3937345 Ki 96.0 nM
CN1C(=N)N[C@](C)(c2sc(-c3nnc(-c4cc5ccccn5n4)o3)cc2Cl)CS1(=O)=O CHEMBL3979775 Ki 96.78 nM
CN1C(=N)N[C@](C)(c2cc(-c3cncc(-c4cnco4)c3)cs2)CS1(=O)=O CHEMBL3928819 Ki 98.0 nM