Cc1cc(-c2cc(O)ccc2Cl)cc2nnc(Nc3ccc(OCCN4CCCC4)cc3)nc12 CHEMBL400402 Kd apparent 3.0 nM
CCOc1cnc(Nc2cccc(S(N)(=O)=O)c2)nc1N1CCN(c2ccccc2)C(=O)C1 CHEMBL5404016 Ki(app) 5.0 nM
CNC(=O)[C@@H]1CC[C@@H](n2c(-c3ccc4cnccc4c3)nc3ccc(C(=O)NCc4cccc(C(N)=O)c4)cc32)C1 CHEMBL5404269 Ki(app) 6.2 nM
COc1cnc(Nc2cccc(S(N)(=O)=O)c2)nc1N1CCN(c2ccccc2)C(=O)C1 CHEMBL5422418 Ki(app) 7.0 nM
CC(=O)NCC(=O)N1C2CCC1c1cc(Nc3ncc(C(F)(F)F)c(NC4CCC4)n3)ccc12 CHEMBL1983111 Kd apparent 8.0 nM
NC(=O)c1cccc(CNC(=O)c2ccc3nc(-c4ccc5cnccc5c4)n(C4CCCC4)c3c2)c1 CHEMBL5434353 Ki(app) 8.0 nM
c1cc(N2CCOCC2)ccc1-c1cnc2c(-c3cn[nH]c3)cnn2c1 CHEMBL2385579 IC50 15.9 nM
COc1cnc(Nc2cccc(S(N)(=O)=O)c2)nc1N1CCN(c2ccccn2)CC1 CHEMBL5420022 Ki(app) 16.0 nM
COc1cnc(Nc2cccc(S(N)(=O)=O)c2)nc1N1CC(F)(c2ccccc2)C1 CHEMBL5437902 Ki(app) 18.0 nM
Cc1[nH]c(/C=C2\C(=O)Nc3ccccc32)c(C)c1CCC(=O)O CHEMBL274654 Kd apparent 19.0 nM
CNC(=O)CCc1ccc(C(=O)NCc2cccc(N3CCN(c4nc(Nc5cccc(S(N)(=O)=O)c5)ncc4OC)CC3)c2)cc1 CHEMBL5398151 Ki(app) 20.6 nM
Cn1c(-c2ccc3cnccc3c2)nc2ccc(C(=O)NCc3cccc(C(N)=O)c3)cc21 CHEMBL5436042 Ki(app) 22.0 nM
COc1ccc(-c2cnc3c(-c4cn[nH]c4)cnn3c2)cc1 CHEMBL2385600 IC50 24.0 nM
N#CCc1ccc(Nc2nccc(Nc3cc(C4CC4)[nH]n3)n2)cc1 CHEMBL1235645 IC50 36.2 nM
CNC(=O)[C@@H]1CC[C@@H](n2c(-c3ccc4cnccc4c3)nc3ccc(C(=O)NCc4ccccc4)cc32)C1 CHEMBL5428614 Ki(app) 39.0 nM
COc1cnc(Nc2cccc(S(N)(=O)=O)c2)nc1N1CCN(c2ccccc2)CC1 CHEMBL5402879 Ki(app) 40.0 nM
O=C(Nc1c[nH]nc1-c1nc2ccc(CN3CCOCC3)cc2[nH]1)NC1CC1 CHEMBL495727 Kd apparent 43.0 nM
COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(N(C)C(=O)CN2CCN(C)CC2)cc1)c1ccccc1 CHEMBL502835 Kd 56.0 nM
c1cc(N2CCNCC2)ccc1-c1cnc2c(-c3cn[nH]c3)cnn2c1 CHEMBL2385586 IC50 59.0 nM
c1cc(-c2cnn3cc(-c4ccc(OCCN5CCCCC5)cc4)cnc23)ccn1 CHEMBL478629 IC50 74.0 nM
O=C1NCCc2ccc(cc2)Nc2nccc(n2)Nc2cc1[nH]n2 CHEMBL5271697 Kd 83.5 nM
COc1cnc(Nc2cccc(S(N)(=O)=O)c2)nc1N1CCN(c2ccccc2)CC1C CHEMBL5421520 Ki(app) 88.0 nM
CC(C)n1nc(-c2cc3cc(O)ccc3[nH]2)c2c(N)ncnc21 CHEMBL1241674 Kd 89.0 nM
COc1cnc(Nc2cccc(S(N)(=O)=O)c2)nc1N1CCN(c2ccccc2)C(C)C1 CHEMBL5409160 Ki(app) 118.0 nM
COCCN1CCN(Cc2ccc(-c3n[nH]c4c3C(=O)c3c(NC(=O)NN5CCOCC5)cccc3-4)cc2)CC1 CHEMBL3545083 Kd apparent 153.0 nM
[2H]C([2H])([2H])NC(=O)c1nnc(NC(=O)C2CC2)cc1Nc1cccc(-c2ncn(C)n2)c1OC CHEMBL4435170 IC50 193.0 nM
Cc1[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c(C)c1C(=O)NC[C@H](O)CN1CCOCC1 CHEMBL1721885 Kd 200.0 nM
COc1cnc(Nc2cccc(S(N)(=O)=O)c2)nc1N1CCN(c2ccccc2)CC12CC2 CHEMBL5408480 Ki(app) 220.0 nM
COc1cnc(Nc2cccc(S(N)(=O)=O)c2)nc1N1CC2CCC(C1)N2c1ccccc1 CHEMBL5397482 Ki(app) 220.0 nM
NS(=O)(=O)c1cccc(Nc2ncc(F)c(N3CCN(c4ccccc4)C(=O)C3)n2)c1 CHEMBL5399442 Ki(app) 236.0 nM
COc1cnc(Nc2cccc(S(N)(=O)=O)c2)nc1N1CCNCC1 CHEMBL5400260 Ki(app) 250.0 nM
CN(C)CC(=O)N1CCC(c2ccc(NC(=O)c3nc(C#N)c[nH]3)c(C3=CCCCC3)c2)CC1 CHEMBL1908395 Kd 310.0 nM
CN(C)CC(=O)N1CCC(c2ccc(NC(=O)c3nc(C#N)c[nH]3)c(C3=CCCCC3)c2)CC1 CHEMBL1908842 Kd 310.0 nM
COc1cnc(Nc2cccc(S(N)(=O)=O)c2)nc1N1CC2CCC1CN2c1ccccc1 CHEMBL5438139 Ki(app) 310.0 nM
O=C(c1ccc(/C=C/c2n[nH]c3ccccc23)cc1)N1CCNCC1 CHEMBL1908397 Kd 370.0 nM
COc1cnc(Nc2cccc(S(N)(=O)=O)c2)nc1N1CCN(c2ccccc2)CC1C(F)(F)F CHEMBL5411422 Ki(app) 430.0 nM
O=C1NCCc2cccc(c2)Nc2nccc(n2)Nc2cc1[nH]n2 CHEMBL5271220 IC50 461.0 nM
NS(=O)(=O)c1ccc(CNc2nc(Nc3cccc(NC(=O)N4CCCC4)c3)ncc2Br)cc1 CHEMBL5079149 IC50 488.0 nM
CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C CHEMBL535 Kd 570.0 nM
COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl CHEMBL288441 Kd 580.0 nM
O=C1NCCCCCNc2nccc(n2)Nc2cc1[nH]n2 CHEMBL5278418 IC50 630.0 nM
c1cc(-c2cnn3cc(-c4ccc(N5CCNCC5)cc4)cnc23)c2cccnc2c1 CHEMBL2385591 IC50 695.0 nM
Nc1nc(Nc2ccc(S(N)(=O)=O)cc2)nn1C(=O)c1c(F)cccc1F CHEMBL191003 Kd 880.0 nM
N#CC[C@H](C1CCCC1)n1cc(-c2ncnc3[nH]ccc23)cn1 CHEMBL1789941 Kd 930.0 nM
COc1cnc(Nc2cccc(S(N)(=O)=O)c2)nc1N1CC2CC1CN2c1ccccc1 CHEMBL5434246 Ki(app) 930.0 nM
CN1C(=O)[C@@H](N2CCc3cn(Cc4ccccc4)nc3C2=O)COc2ccccc21 CHEMBL4088216 pIC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3c(nn(Cc4ccccc4)c3Br)C2=O)COc2ccccc21 CHEMBL4549667 pIC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3cn(CC4CCS(=O)(=O)CC4)nc3C2=O)COc2ccccc21 CHEMBL4097778 pIC50 1000.0 nM