Cn1cc(-c2ccc3c(c2)CC/C3=N\O)c(-c2ccncc2)n1 CHEMBL500659 IC50 0.02 nM
O/N=C1\CCc2cc(-c3cn(C4CCNCC4)nc3-c3ccncc3)ccc21 CHEMBL526479 IC50 0.03 nM
O/N=C1\CCc2cc(-c3cn([C@@H]4CCC[C@H](O)C4)nc3-c3ccncc3)ccc21 CHEMBL498344 IC50 0.04 nM
OCCCn1cc(-c2ccc3c(c2)CC/C3=N\O)c(-c2ccncc2)n1 CHEMBL527029 IC50 0.05 nM
CN1CCN(CCNc2nccc(-c3c(-c4cccc(O)c4)nc4sccn34)n2)S1(=O)=O CHEMBL5087577 IC50 0.07 nM
CCCS(=O)(=O)Nc1cc(Cl)cc(-c2[nH]c(C(C)(C)C)nc2-c2ccnc(N)n2)c1F CHEMBL3651664 IC50 0.08 nM
CS(=O)(=O)Nc1cc(Cl)cc(-c2[nH]c(C3CC3)nc2-c2ccnc(NCCC#N)n2)c1F CHEMBL3651683 IC50 0.08 nM
O/N=C1\CCc2cc(-c3cn([C@@H]4CCC[C@@H](O)C4)nc3-c3ccncc3)ccc21 CHEMBL521562 IC50 0.09 nM
CCCS(=O)(=O)Nc1ccc(F)c(-c2cc3cnc(NC[C@H](C)NC(=O)OC)cc3cc2OC)c1F CHEMBL3752213 IC50 0.1 nM
Nc1nccc(-c2nc(C3CC3)[nH]c2-c2cc(Cl)cc(NS(=O)(=O)c3c(F)cccc3F)c2F)n1 CHEMBL3651662 IC50 0.1 nM
COC(=O)N[C@@H](C)CNc1nccc(-c2nc(C3CC3)[nH]c2-c2cc(F)cc(NS(=O)(=O)c3c(F)cccc3F)c2Cl)n1 CHEMBL3651665 IC50 0.1 nM
CCCS(=O)(=O)Nc1cc(Cl)cc(-c2[nH]c(C(C)(C)C)nc2-c2ccnc(NC[C@H](C)NC(=O)OC)n2)c1 CHEMBL3651609 IC50 0.1 nM
COC(=O)N[C@@H](C)CNc1nccc(-c2nc(C(C)(C)C)[nH]c2-c2cc(Cl)cc(NS(=O)(=O)C3CC3)c2)n1 CHEMBL3651610 IC50 0.1 nM
CCS(=O)(=O)Nc1cc(Cl)cc(-c2[nH]c(C(C)(C)C)nc2-c2ccnc(NC[C@H](C)NC(=O)OC)n2)c1 CHEMBL3651613 IC50 0.1 nM
OCCn1cc(-c2ccc3c(c2)CC/C3=N/O)c(-c2ccncc2)n1 CHEMBL5287468 IC50 0.1 nM
CNc1ncc2cc(-c3cc(NC(=O)NCCC(C)(C)C)c(F)cc3C)c(=O)n(C)c2n1 CHEMBL4740241 Ki 0.102 nM
Nc1ncnc2c(C(=O)Nc3c(Cl)ccc(NS(=O)(=O)CCCF)c3F)cccc12 CHEMBL2047875 pIC50 0.1096 nM
CN1C[C@@H]2C[C@H]1CN2c1cc(F)c(-c2ccnc3c(-c4ccc(F)c5[nH]ncc45)c(-c4ccncc4)nn23)c(F)c1 CHEMBL1276186 IC50 0.11 nM
CC1(c2nc(-c3ccnc(NCCC#N)n3)c(-c3cc(Cl)cc(NS(C)(=O)=O)c3F)[nH]2)CC1 CHEMBL3651658 IC50 0.11 nM
CCCS(=O)(=O)Nc1cc(F)cc(-c2[nH]c(C3CC3)nc2-c2ccnc(NC)n2)c1Cl CHEMBL3651680 IC50 0.11 nM
CCCS(=O)(=O)Nc1c(F)ccc(-c2[nH]c(C(C)(C)C)nc2-c2ccnc(NC[C@H](C)NC(=O)OC)n2)c1F CHEMBL3651703 IC50 0.12 nM
Cc1cc(F)c(C(=O)NCCCC(C)(C)C)cc1-c1ccc2c(=O)n(C)ncc2c1 CHEMBL4776565 Ki 0.12 nM
OCCn1cc(-c2ccc3c(c2)CC/C3=N\O)c(-c2ccncc2)n1 CHEMBL525191 IC50 0.13 nM
CC(C)(C)c1nc(-c2ccnc(N)n2)c(-c2cc(Cl)cc(NS(=O)(=O)c3c(F)cccc3F)c2F)[nH]1 CHEMBL3651661 IC50 0.13 nM
CCCS(=O)(=O)Nc1cccc(-c2[nH]c(C3CC3)nc2-c2ccnc(NC[C@H](C)NC(=O)OC)n2)c1Cl CHEMBL3651695 IC50 0.13 nM
CCCS(=O)(=O)Nc1cccc(-c2[nH]c(C3CC3)nc2-c2ccnc(NCCC#N)n2)c1F CHEMBL3651701 IC50 0.13 nM
OCCn1cc(-c2ccc3c(c2)CCC3=NO)c(-c2ccncc2)n1 CHEMBL2139930 IC50 0.13 nM
CNc1ncc2cc(-c3cc(NC(=O)NCCC(C)(C)C)c(F)cc3C)c(C)nc2n1 CHEMBL3577124 Ki 0.139 nM
O/N=C1\CCc2cc(-c3c[nH]nc3-c3ccncc3)ccc21 CHEMBL500406 IC50 0.15 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1nc(N2CCOCC2)c2sccc2n1 CHEMBL3933272 IC50 0.152 nM
CN(C)CCOc1ccc(-c2nc(-c3ccncc3)c(-c3ccc4c(c3)CC/C4=N\O)[nH]2)cc1 CHEMBL477989 Ki(app) 0.16 nM
CN1C[C@@H]2C[C@H]1CN2c1cc(F)c(-c2ccnc3c(-c4cccc5[nH]ncc45)c(-c4ccncc4)nn23)c(F)c1 CHEMBL1276179 IC50 0.16 nM
CCCS(=O)(=O)Nc1cccc(-c2[nH]c(C3CC3)nc2-c2ccnc(NC[C@H](C)NC(=O)OC)n2)c1F CHEMBL3651697 IC50 0.16 nM
COc1n[nH]c2ncc(NC(=O)c3cc(NC(=O)NCCC(C)(C)C)c(F)cc3C)cc12 CHEMBL5090624 Ki 0.165 nM
Nc1ncnc2c(C(=O)Nc3c(Cl)ccc(NS(=O)(=O)CCCF)c3F)csc12 CHEMBL2047879 IC50 0.18 nM
COC(=O)N[C@@H](C)CNc1nccc(-c2nc(C3CC3)[nH]c2-c2cc(Cl)cc(NS(C)(=O)=O)c2Cl)n1 CHEMBL3651628 IC50 0.18 nM
COC(=O)N[C@@H](C)CNc1nccc(-c2nc(C3CC3)[nH]c2-c2cc(Cl)cc(NS(=O)(=O)C3CC3)c2F)n1 CHEMBL3651629 IC50 0.18 nM
Nc1nccc(-c2nc(C3CC3)[nH]c2-c2cc(F)cc(NS(=O)(=O)c3c(F)cccc3F)c2Cl)n1 CHEMBL3651674 IC50 0.19 nM
Cc1cc(F)c(NC(=O)c2cccc(C(C)(C)C#N)c2)cc1-c1cnc2c(=O)n(C)ncc2c1 CHEMBL4778419 Ki 0.19 nM
O/N=C1\CCc2cc(Nc3c(-c4ncccn4)oc4cnccc34)ccc21 CHEMBL1668922 IC50 0.2 nM
COc1n[nH]c2ncc(NC(=O)c3c(F)ccc(NS(=O)(=O)c4cccs4)c3F)cc12 CHEMBL1822264 IC50 0.2 nM
CCCS(=O)(=O)Nc1ccc(Cl)c(Nc2ccc3ncn(C)c(=O)c3c2)c1C#N CHEMBL3236463 IC50 0.2 nM
CCCS(=O)(=O)Nc1ccc(Cl)c(Oc2ccc3ncn(C)c(=O)c3c2)c1C#N CHEMBL3236470 IC50 0.2 nM
CCCS(=O)(=O)Nc1ccc(F)c(Oc2ccc3ncn(C)c(=O)c3c2)c1C#N CHEMBL3236471 IC50 0.2 nM
CNS(=O)(=O)c1ccc(N(C)C)c(Nc2ncnc3[nH]cc(Br)c23)c1 CHEMBL3613198 IC50 0.2 nM
O=S(=O)(Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F)c1cn[nH]c1 CHEMBL3797403 IC50 0.2 nM
CCCS(=O)(=O)Nc1cc(Cl)cc(-c2nn(C(C)C)cc2-c2ccnc(NC[C@H](C)NC(=O)OC)n2)c1 CHEMBL3932572 IC50 0.2 nM
CCCS(=O)(=O)Nc1cc(F)cc(-c2[nH]c(C3CC3)nc2-c2ccnc(N)n2)c1Cl CHEMBL3651675 IC50 0.2 nM
COC(=O)N[C@@H](C)CNc1nccc(-c2[nH]c(C3CC3)nc2-c2cc(Cl)cc(NS(C)(=O)=O)c2F)n1 CHEMBL3705042 IC50 0.2 nM
COC(=O)N[C@@H](C)CNc1nccc(-c2nc(C3CC3)[nH]c2-c2cc(C)cc(NS(C)(=O)=O)c2F)n1 CHEMBL3651606 IC50 0.2 nM
COC(=O)N[C@@H](C)CNc1nccc(-c2nc(C3CC3)[nH]c2-c2cc(F)cc(NS(C)(=O)=O)c2F)n1 CHEMBL3651626 IC50 0.2 nM
CC(=O)Nc1cn2cc(-c3cc(NC(=O)c4cccc(C(F)(F)F)c4)ccc3C)ccc2n1 CHEMBL4216073 IC50 0.2 nM
Cc1ccc(C(=O)Nc2cccc(Cl)c2)cc1NC(=O)C1(c2ncnc3[nH]ccc23)CC1 CHEMBL4438001 IC50 0.2 nM
O/N=C1\CCc2cc(-c3cn(C4CCOCC4)nc3-c3ccncc3)ccc21 CHEMBL497671 IC50 0.22 nM
CC(C)(C)c1nc(-c2ccnc(N)n2)c(-c2cccc(NS(=O)(=O)c3c(F)cccc3F)c2Cl)[nH]1 CHEMBL3651667 IC50 0.22 nM
CNC1CCCC(n2cc(-c3ccc4c(c3)CC/C4=N\O)c(-c3ccncc3)n2)C1 CHEMBL498688 IC50 0.23 nM
CN1C[C@@H]2C[C@H]1CN2c1ccc(-c2ccnc3c(-c4cccc5[nH]ncc45)c(-c4ccncc4)nn23)c(F)c1 CHEMBL1276169 IC50 0.23 nM
CC1(c2nc(-c3ccnc(NCCC#N)n3)c(-c3cc(F)cc(NS(C)(=O)=O)c3Cl)[nH]2)CC1 CHEMBL3651655 IC50 0.23 nM
COC(=O)N[C@@H](C)CNc1nccc(-c2nc(C3CCC3)[nH]c2-c2cc(Cl)cc(NS(C)(=O)=O)c2F)n1 CHEMBL3651676 IC50 0.23 nM
CCS(=O)(=O)Nc1cc(Cl)cc(-c2[nH]c(C3CC3)nc2-c2ccnc(NC[C@H](C)NC(=O)OC)n2)c1F CHEMBL3651630 IC50 0.24 nM
COC(=O)N[C@@H](C)CNc1nccc(-c2nc(C3CC3)[nH]c2-c2cc(C)cc(NS(=O)(=O)CC(F)(F)F)c2F)n1 CHEMBL3651671 IC50 0.25 nM
Cc1nn(C)cc1-c1cc(C(=O)Nc2c(Cl)ccc(NS(=O)(=O)c3ccccc3Cl)c2F)c2ncnc(N)c2c1 CHEMBL4758147 Ki 0.25 nM
CC(C)(C)c1nc(-c2ccnc(N)n2)c(-c2cc(F)cc(NS(=O)(=O)c3c(F)cccc3F)c2Cl)[nH]1 CHEMBL3651672 IC50 0.26 nM
COC(=O)N[C@@H](C)CNc1nccc(-c2nc(C3CC3)[nH]c2-c2cc(Cl)cc(NS(=O)(=O)CC3CC3)c2F)n1 CHEMBL3651633 IC50 0.26 nM
COC(=O)N[C@@H](C)CNc1nccc(-c2nc(C(C)(C)C)[nH]c2-c2cccc(NS(=O)(=O)C3CC3)c2F)n1 CHEMBL3651684 IC50 0.27 nM
COC(=O)N[C@@H](C)CNc1nccc(-c2nc(C(C)(C)C)[nH]c2-c2cc(Cl)cc(NS(C)(=O)=O)c2F)n1 CHEMBL3651639 IC50 0.28 nM
Cc1cc(NS(C)(=O)=O)c(Cl)c(-c2[nH]c(C3(C)CC3)nc2-c2ccnc(NCCC#N)n2)c1 CHEMBL3651656 IC50 0.29 nM
CC(=O)N1C2CCC1CC(c1ccnc3c(-c4ccc(Cl)c(O)c4)c(-c4ccncc4)nn13)C2 CHEMBL578391 IC50 0.3 nM
Cc1cc(Nc2c(-c3ncccn3)oc3cnccc23)c2cn[nH]c2c1Cl CHEMBL1667922 IC50 0.3 nM
CC(C)c1nc(-c2cccc(NS(=O)(=O)c3c(F)cccc3F)c2F)c(-c2ccnc(NCCS(C)(=O)=O)n2)s1 CHEMBL2337916 IC50 0.3 nM
CCCS(=O)(=O)Nc1cccc(Nc2ccc3ncn(C)c(=O)c3c2)c1C#N CHEMBL3236464 IC50 0.3 nM
CCCS(=O)(=O)Nc1cccc(Oc2ccc3ncn(C)c(=O)c3c2)c1C#N CHEMBL3236472 IC50 0.3 nM
COC(=O)N[C@@H](C)CNc1nccc(-c2cn(C(C)C)nc2-c2cc(Cl)cc(NS(C)(=O)=O)c2F)n1 CHEMBL3301612 IC50 0.3 nM
COC(=O)N[C@@H](C)CNc1nccc(-c2nc(C(C)(C)C)[nH]c2-c2cc(Cl)cc(NS(=O)(=O)CC(C)C)c2)n1 CHEMBL3651611 IC50 0.3 nM
COC(=O)N[C@@H](C)CNc1nccc(-c2nc(C3CC3)[nH]c2-c2cc(F)cc(NS(=O)(=O)C3CC3)c2Cl)n1 CHEMBL3651635 IC50 0.3 nM
CNc1cc(C2(C(=O)Nc3cc(C(=O)Nc4cccc(Cl)c4)ccc3C)CC2)ncn1 CHEMBL4061139 IC50 0.3 nM
CC(=O)Nc1cn2cc(-c3cc(NC(=O)c4cccc(Cl)c4)ccc3C)ccc2n1 CHEMBL4216386 IC50 0.3 nM
CC(=O)Nc1cn2cc(-c3cc(NC(=O)c4cccc(C(C)(C)C)c4)ccc3C)ccc2n1 CHEMBL4217462 IC50 0.3 nM
CN(C)CCOc1ccc(-c2n/c(=c3\ccc4c(c3)CCC=4N=O)c(=C3C=CNC=C3)[nH]2)cc1 CHEMBL5271555 IC50 0.3 nM
CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(-c4ccc(C(=O)NCCOCCOCCOCCCCC(=O)N[C@H](C(=O)N5C[C@H](O)C[C@H]5C(=O)NCc5ccc(-c6scnc6C)cc5)C(C)(C)C)cc4)cc23)c1F CHEMBL5196107 IC50 0.31 nM
COC(=O)N[C@@H](C)CNc1nccc(-c2nc(C(C)(C)C)[nH]c2-c2cc(Cl)cc(NS(C)(=O)=O)c2)n1 CHEMBL3651607 IC50 0.32 nM
O/N=C1\CCc2cc(-c3cn([C@H]4CCC[C@@H]4O)nc3-c3ccncc3)ccc21 CHEMBL524640 IC50 0.33 nM
COC(=O)N[C@@H](C)CNc1nccc(-c2nc(C3CC3)[nH]c2-c2cc(Cl)cc(NS(=O)(=O)c3cccc(F)c3)c2F)n1 CHEMBL3651654 IC50 0.33 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)nc(N2CCOCC2)n1 CHEMBL3967893 IC50 0.33 nM
CCCS(=O)(=O)Nc1ccc(F)c(-n2cc(-c3cncnc3)c3nc(N(C)C4CCN(CC)CC4)ccc32)c1F CHEMBL4212692 Kd 0.33 nM
CN1CCC(n2cc(-c3ccc4c(c3)CC/C4=N\O)c(-c3ccncc3)n2)CC1 CHEMBL498674 IC50 0.34 nM
CN1C[C@@H]2C[C@H]1CN2c1c(F)c(F)c(-c2ccnc3c(-c4cccc5[nH]ncc45)c(-c4ccncc4)nn23)c(F)c1F CHEMBL1276181 IC50 0.35 nM
Cc1cc(NS(C)(=O)=O)c(F)c(-c2[nH]c(C3(C)CC3)nc2-c2ccnc(NCCC#N)n2)c1 CHEMBL3651657 IC50 0.37 nM
COC(=O)N[C@@H](C)CNc1nccc(-c2nc(C3CC3)[nH]c2-c2cc(Cl)cc(NS(=O)(=O)c3cc(F)cc(F)c3)c2F)n1 CHEMBL3651669 IC50 0.37 nM
CN1C[C@@H]2C[C@H]1CN2c1ccc(-c2ccnc3c(-c4cccc(O)c4)c(-c4ccncc4)nn23)cc1 CHEMBL1087650 IC50 0.38 nM
CN1C[C@@H]2C[C@H]1CN2c1cc(F)c(-c2ccnc3c(-c4cccc5[nH]ncc45)c(-c4ccncc4)nn23)cc1F CHEMBL1276178 IC50 0.38 nM
CCCS(=O)(=O)Nc1cccc(-c2[nH]c(C(C)(C)C)nc2-c2ccnc(NC[C@H](C)NC(=O)OC)n2)c1F CHEMBL3651696 IC50 0.38 nM
Cc1ccc(NC(=O)c2cccc(C(F)F)c2)cc1-c1ccnc(N2CCOCC2)c1 CHEMBL3951474 IC50 0.385 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cn2ccnc2c(N2CCOCC2)n1 CHEMBL3905257 IC50 0.389 nM
NCCCn1cc(-c2ccc3c(c2)CC/C3=N\O)c(-c2ccncc2)n1 CHEMBL498496 IC50 0.39 nM
CCCNc1nccc(-c2nc(C3CC3)[nH]c2-c2cc(F)cc(NS(=O)(=O)CCC)c2Cl)n1 CHEMBL3651644 IC50 0.39 nM
CCCS(=O)(=O)Nc1ccc(F)c(-c2cc3cnc(Nc4cnn(C)c4)nc3n(C)c2=O)c1F CHEMBL2023502 pIC50 0.3981 nM
Oc1cc(-c2c(-c3ccncc3)nn3c(C4CC5CCC(C4)N5)ccnc23)ccc1Cl CHEMBL569081 IC50 0.4 nM
CCOC(=O)N1C2CCC1CC(c1ccnc3c(-c4ccc(Cl)c5[nH]ncc45)c(-c4ccncc4)nn13)C2 CHEMBL585144 IC50 0.4 nM
CCOC(=O)N1C2CCC1CC(c1ccnc3c(-c4ccc(F)c5[nH]ncc45)c(-c4ccncc4)nn13)C2 CHEMBL570681 IC50 0.4 nM
CC(=O)Nc1cc(Oc2ccc3c(c2)nc(Nc2cccc(OC(F)(F)F)c2)n3C)ccn1 CHEMBL3335374 IC50 0.4 nM
CC(C)(C)c1nc(-c2cccc(NS(=O)(=O)c3c(F)cccc3F)c2F)c(-c2ccnc(N)n2)s1 CHEMBL2028663 IC50 0.4 nM
COC(=O)N[C@@H](C)CNc1nccc(-c2nc(C3CC3)[nH]c2-c2cc(F)cc(NS(C)(=O)=O)c2Cl)n1 CHEMBL3651706 IC50 0.4 nM
Cc1ncc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cnc(OC2CCOCC2)c(N2CCOCC2)c1 CHEMBL3962812 IC50 0.4 nM
Cc1ccc(NC(=O)c2ccnc(C(F)(F)F)c2)cc1-c1cc(OCCO)nc(N2CCOCC2)c1 CHEMBL4583691 IC50 0.4 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)ncn1 CHEMBL3956654 IC50 0.408 nM
CN1C[C@@H]2CC[C@H]1CN2c1ccc(-c2ccnc3c(-c4cccc5[nH]ncc45)c(-c4ccncc4)nn23)c(F)c1 CHEMBL1276188 IC50 0.41 nM
C=C(C)c1cc(-c2cc(NC(=O)c3cccc(C(F)(F)F)c3)ccc2C)nc(N2CCOCC2)n1 CHEMBL3959581 IC50 0.422 nM
CCS(=O)(=O)Nc1cc(F)cc(-c2[nH]c(C3CC3)nc2-c2ccnc(NC[C@H](C)NC(=O)OC)n2)c1Cl CHEMBL3651634 IC50 0.43 nM
COc1cccc(-c2c(-c3ccncc3)nn3c(-c4ccc(N5C[C@@H]6C[C@H]5CN6)cc4F)ccnc23)c1 CHEMBL1080652 IC50 0.44 nM
CCCS(=O)(=O)Nc1ccc(F)c(-c2[nH]c(C3CC3)nc2-c2ccnc(NC[C@H](C)NC(=O)OC)n2)c1Cl CHEMBL3651636 IC50 0.45 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)nc(-n2ccnc2)n1 CHEMBL3928030 IC50 0.455 nM
Cc1ccc(NC(=O)c2cncc(N(C)C)c2)cc1-c1cc(N2CCOCC2)nc(N2CCOCC2)n1 CHEMBL3976881 IC50 0.456 nM
Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1ncccc1-c1ccncn1 CHEMBL385956 IC50 0.46 nM
CCS(=O)(=O)Nc1cc(Cl)cc(-c2[nH]c(C(C)(C)C)nc2-c2ccnc(NC[C@H](C)NC(=O)OC)n2)c1F CHEMBL3651640 IC50 0.46 nM
CN(C)CCCn1cc(-c2ccc3c(c2)CC/C3=N\O)c(-c2ccncc2)n1 CHEMBL498503 IC50 0.47 nM
COC(=O)N[C@@H](C)CNc1nccc(-c2nc(C3CC3)[nH]c2-c2cccc(NS(C)(=O)=O)c2Cl)n1 CHEMBL3651624 IC50 0.47 nM
Cn1ncc(-c2ccc3c(c2)CC/C3=N\O)c1-c1ccncc1 CHEMBL500660 IC50 0.48 nM
COC(=O)N[C@@H](C)CNc1nccc(-c2nc(C3CC3)[nH]c2-c2cc(Cl)cc(NS(C)(=O)=O)c2)n1 CHEMBL3651623 IC50 0.48 nM
Oc1cccc(-c2c(-c3ccncc3)nn3c(-c4ccc(N5C[C@@H]6C[C@H]5CN6)cc4)ccnc23)c1 CHEMBL1087000 IC50 0.49 nM
CC(COc1nccc(-c2nc(-c3ccc4c(c3)CC/C4=N\O)c(-c3ccncc3)[nH]2)n1)N(C)C CHEMBL478190 Kd 0.5 nM
CN(C)CCNC(=O)c1cc(-c2ccc3c(c2)CC/C3=N\O)c(-c2ccncc2)o1 CHEMBL514210 Kd 0.5 nM
CN(C)CCOc1ccc(-c2cc(-c3ccc4c(c3)CCC4=NO)c(-c3ccncc3)o2)cc1 CHEMBL1794072 Kd 0.5 nM
CCN1C2CCC1CC(c1ccnc3c(-c4ccc(Cl)c(O)c4)c(-c4ccncc4)nn13)C2 CHEMBL571130 IC50 0.5 nM
CC(=O)N1C[C@@H]2C[C@H]1CN2c1ccc(-c2ccnc3c(-c4ccc(F)c(O)c4)c(-c4ccncc4)nn23)cc1 CHEMBL1076206 IC50 0.5 nM
CN1C[C@@H]2C[C@H]1CN2c1ccc(-c2ccnc3c(-c4ccc(F)c5[nH]ncc45)c(-c4ccncc4)nn23)cc1 CHEMBL1276183 IC50 0.5 nM
O/N=C1\NCc2cc(Nc3c(-c4ncccn4)oc4cnccc34)ccc21 CHEMBL1667899 IC50 0.5 nM
CC(C)c1nc(-c2cccc(NS(=O)(=O)c3c(F)cccc3F)c2F)c(-c2ccnc(Nc3ccc(N4CCOCC4)nc3)n2)s1 CHEMBL1808262 IC50 0.5 nM
COc1n[nH]c2ncc(NC(=O)c3c(F)ccc(NS(=O)(=O)c4cccnc4)c3F)cc12 CHEMBL1822262 IC50 0.5 nM
CCCS(=O)(=O)Nc1ccc(F)c(-c2cc3cnc(Nc4ccccc4)nc3n(C)c2=O)c1F CHEMBL2023500 IC50 0.5 nM
CCCS(=O)(=O)Nc1ccc(F)c(-c2cc3cnc(Nc4cccnc4)nc3n(C)c2=O)c1F CHEMBL2023501 IC50 0.5 nM
CNS(=O)(=O)c1ccc(N(C)C)c(Nc2ncnc3[nH]cc(C)c23)c1 CHEMBL3613197 IC50 0.5 nM
CNS(=O)(=O)c1ccc(N2CCOCC2)c(Nc2ncnc3[nH]cc(Br)c23)c1 CHEMBL3613305 IC50 0.5 nM
Cn1c(Nc2ccc(C(F)(F)F)cc2)nc2cc(Oc3ccnc(-c4ncc(C(F)(F)F)[nH]4)c3)ccc21 CHEMBL558752 IC50 0.5 nM
O=S(=O)(Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F)c1cccs1 CHEMBL3798780 IC50 0.5 nM
CCn1cc(-c2ccnc(NC[C@H](C)NC(=O)OC)n2)c(-c2cc(Cl)cc(NS(C)(=O)=O)c2F)n1 CHEMBL3928966 IC50 0.5 nM
CCC(C)S(=O)(=O)Nc1cc(Cl)cc(-c2[nH]c(C(C)(C)C)nc2-c2ccnc(NC[C@H](C)NC(=O)OC)n2)c1 CHEMBL3651612 IC50 0.5 nM
CCN1C[C@@H]2C[C@H]1CN2c1ccc(-c2ccnc3c(-c4ccc(F)c(O)c4)c(-c4ccncc4)nn23)cc1 CHEMBL1080650 IC50 0.51 nM
Cc1cc(N2C[C@@H]3C[C@H]2CN3C)ccc1-c1ccnc2c(-c3cccc4[nH]ncc34)c(-c3ccncc3)nn12 CHEMBL1276168 IC50 0.51 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2=O)nc(N2CCOCC2)n1 CHEMBL3984282 IC50 0.51 nM
Fc1cc(CN2C[C@H]3C[C@@H]2CO3)ccc1-c1ccnc2c(-c3cccc4[nH]ncc34)c(-c3ccncc3)nn12 CHEMBL1276190 IC50 0.52 nM
CCCS(=O)(=O)Nc1cc(Cl)cc(-c2[nH]c(C(C)(C)C)nc2-c2ccnc(NC[C@H](C)NC(=O)OC)n2)c1F CHEMBL3651700 IC50 0.53 nM
CCCS(=O)(=O)Nc1ccc(F)c(NC(=O)c2cccc3c(N)ncnc23)c1Cl CHEMBL2047874 pIC50 0.537 nM
COC(=O)N[C@@H](C)CNc1nccc(-c2nc(C3CC3)[nH]c2-c2cccc(NS(C)(=O)=O)c2F)n1 CHEMBL3651625 IC50 0.55 nM
OCC(CO)n1cc(-c2ccc3c(c2)CC/C3=N\O)c(-c2ccncc2)n1 CHEMBL498487 IC50 0.56 nM
CCn1cc(-c2ccc3c(c2)CC/C3=N\O)c(-c2ccncc2)n1 CHEMBL502816 IC50 0.57 nM
c1cc(-c2nn(C3CC4CCC(C3)N4)cc2-c2ccc3c(c2)Cc2c[nH]nc2-3)ccn1 CHEMBL1780167 IC50 0.57 nM
CCNc1nc(-c2cc(NC(=O)c3cccc(C(F)(F)F)c3)ccc2C)cc(N2CCOCC2)n1 CHEMBL3946003 IC50 0.585 nM
CCCS(=O)(=O)Nc1ccc(Cl)c(NC(=O)c2cccc3c(N)ncnc23)c1F CHEMBL2046458 pIC50 0.5888 nM
CN1C2CC(CO)C1Cc1cnc3c(-c4ccc(Cl)c(O)c4)c(-c4ccncc4)nn3c12 CHEMBL570873 IC50 0.6 nM
CC(=O)N1CCN(c2ccc(Nc3nccc(-c4sc(C(C)C)nc4-c4cccc(NS(=O)(=O)c5cc(F)ccc5F)c4)n3)cn2)CC1 CHEMBL1808259 IC50 0.6 nM
CC(=O)N1CCN(c2ccc(Nc3nccc(-c4sc(C(C)C)nc4-c4cccc(NS(=O)(=O)c5ccccc5F)c4)n3)cn2)CC1 CHEMBL1808255 IC50 0.6 nM
O=C(Nc1cnc2[nH]nc(C3CC3)c2c1)c1c(F)ccc(NS(=O)(=O)CCCF)c1Cl CHEMBL1939073 IC50 0.6 nM
Cc1ccc(NC(=O)c2cccc(C(C)(C)C#N)c2)cc1Nc1ccc2ncn(C)c(=O)c2c1 CHEMBL2144069 IC50 0.6 nM
CNS(=O)(=O)c1ccc(N(C)C)c(Nc2ncnc3[nH]c(-c4cccc(C(F)(F)F)c4)cc23)c1 CHEMBL3613307 IC50 0.6 nM
CCCS(=O)(=O)Nc1ccc(F)c(-c2cc3cnc(NC[C@H](C)NC(=O)OC)cc3cc2CC)c1F CHEMBL3753260 IC50 0.6 nM
CNS(=O)(=O)c1ccc(N2CCOCC2)c(Nc2ncnc3[nH]cc(Cl)c23)c1 CHEMBL3814798 IC50 0.6 nM
COC(=O)N[C@@H](C)CNc1nccc(-c2cn(C(C)C)nc2-c2cc(F)cc(NS(C)(=O)=O)c2F)n1 CHEMBL3931720 IC50 0.6 nM
COC(=O)N[C@@H](C)CNc1nccc(-c2nc(C3CC3)[nH]c2-c2cc(Cl)cc(NS(=O)(=O)CCC(F)(F)F)c2F)n1 CHEMBL3651631 IC50 0.6 nM
CC1(C)OC(c2ccnc(N)n2)=C(c2cc(Cl)cc(NS(=O)(=O)c3cc(F)ccc3F)c2F)C1=O CHEMBL3983123 IC50 0.6 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)nc(OCCO)n1 CHEMBL3987177 IC50 0.601 nM
CN1C[C@@H]2C[C@H]1CN2c1ccc(-c2ccnc3c(-c4cccc5[nH]ncc45)c(-c4ccncc4)nn23)c(F)c1F CHEMBL1276177 IC50 0.61 nM
COC(=O)N[C@@H](C)CNc1nccc(-c2nc(C(C)(C)C)[nH]c2-c2cccc(NS(C)(=O)=O)c2F)n1 CHEMBL3651685 IC50 0.61 nM
COC(=O)N[C@@H](C)CNc1nccc(-c2nc(C3CC3)[nH]c2-c2cc(Cl)cc(NS(=O)(=O)C(C)C)c2)n1 CHEMBL3651617 IC50 0.63 nM
Cc1ncc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)nc(N2CCOCC2)c1 CHEMBL3942721 IC50 0.632 nM
Cc1ccc(NC(=O)c2cccc(S(C)(=O)=O)c2)cc1-c1ccnc(N2CCOCC2)c1 CHEMBL3907015 IC50 0.64 nM
Cc1ccc(NC(=O)c2cccc(OC(F)(F)F)c2)cc1-c1cc(N2CCOCC2)nc(N2CCOCC2)n1 CHEMBL3960775 IC50 0.652 nM
N[C@H]1CC[C@H](n2cc(-c3ccc4c(c3)Cc3c[nH]nc3-4)c(-c3ccncc3)n2)CC1 CHEMBL1780170 IC50 0.66 nM
Cc1ccc(NC(=O)c2cccc(C#N)c2)cc1Nc1ncccc1-c1ncnc2[nH]cnc12 CHEMBL3354836 IC50 0.669 nM
CN(C)CCOc1cc(-c2ccc3c(c2)CC/C3=N\O)c(-c2ccncc2)[nH]1 CHEMBL477565 Kd 0.7 nM
CCOC(=O)N1C2CCC1CC(c1ccnc3c(-c4ccc(C)c5[nH]ncc45)c(-c4ccncc4)nn13)C2 CHEMBL583133 IC50 0.7 nM
COc1n[nH]c2ncc(NC(=O)c3c(F)ccc(NS(=O)(=O)c4ccco4)c3F)cc12 CHEMBL1822265 IC50 0.7 nM
COc1n[nH]c2ncc(NC(=O)c3c(F)ccc(NS(=O)(=O)c4cccc(F)c4)c3F)cc12 CHEMBL1822258 IC50 0.7 nM
O=C(Nc1ccccc1)Nc1cccc(C(=O)Nc2cnc3[nH]ncc3c2)c1 CHEMBL2153639 IC50 0.7 nM
CCCS(=O)(=O)Nc1ccc(F)c(-c2nn(C(C)C)cc2-c2ccnc(NC[C@H](C)NC(=O)OC)n2)c1F CHEMBL3920123 IC50 0.7 nM
Cc1ccc(NC(=O)c2cccc(C(C)(F)F)c2)cc1-c1cc(N2CCOCC2)c(=O)n(C)c1 CHEMBL3914464 IC50 0.706 nM
CN1C[C@@H]2CC[C@H]1CN2c1ccc(-c2ccnc3c(-c4cccc5[nH]ncc45)c(-c4ccncc4)nn23)cc1 CHEMBL1276187 IC50 0.71 nM
Cc1ccc(C(=O)Nc2cccc(C#N)c2)cc1Nc1ncccc1-c1ncnc2[nH]cnc12 CHEMBL3352837 IC50 0.717 nM
O=C1CCc2c(Oc3ccc4c(c3)C3C(O4)C3c3nc(-c4ccccc4)c[nH]3)ccnc2N1 CHEMBL3970406 IC50 0.72 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)nc(NCCO)n1 CHEMBL3955743 IC50 0.737 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)c(=O)n(CC#N)c1 CHEMBL3966766 IC50 0.756 nM
CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]c(-c4cccc(Br)c4)nc3c2)c1F CHEMBL2436807 IC50 0.76 nM
Fc1cc(CN2C3COCC2COC3)ccc1-c1ccnc2c(-c3cccc4[nH]ncc34)c(-c3ccncc3)nn12 CHEMBL1276192 IC50 0.77 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)nc(-n2cc(C(C)(C)O)nn2)n1 CHEMBL3966243 IC50 0.773 nM
CCn1cc(-c2cc(NC(=O)c3cccc(C(F)(F)F)c3)ccc2C)nc(N2CCOCC2)c1=O CHEMBL3930929 IC50 0.775 nM
COC(=O)N[C@@H](C)CNc1nccc(-c2nc(C(C)(C)C)[nH]c2-c2cccc(NS(=O)(=O)C(C)C)c2F)n1 CHEMBL3651686 IC50 0.78 nM
Cc1ccc(NC(=O)c2cccc(N(C)C)c2)cc1Nc1ncccc1-c1ncnc2[nH]cnc12 CHEMBL3354840 IC50 0.79 nM
CN1C2CC(S(=O)(=O)c3ccccc3)C1Cc1cnc3c(-c4ccc(Cl)c(O)c4)c(-c4ccncc4)nn3c12 CHEMBL571112 IC50 0.8 nM
CCc1n[nH]c2c(Cl)ccc(Nc3c(-c4ncccn4)oc4cnccc34)c12 CHEMBL1667923 IC50 0.8 nM
OCCCc1n[nH]c2c(Cl)ccc(Nc3c(-c4ncccn4)oc4cnccc34)c12 CHEMBL1667924 IC50 0.8 nM
CC(=O)N1CCN(c2ccc(Nc3nccc(-c4sc(C(C)C)nc4-c4cccc(NS(=O)(=O)c5cccc(F)c5)c4)n3)cn2)CC1 CHEMBL1808256 IC50 0.8 nM
CCCS(=O)(=O)Nc1ccc(F)c(-c2ccc3cc(NC[C@H](C)NC(=O)OC)ncc3c2)c1F CHEMBL3754618 IC50 0.8 nM
CCCS(=O)(=O)Nc1ccc(F)c(-c2cc3cnc(N)cc3cc2OC)c1F CHEMBL3752762 IC50 0.8 nM
COC(=O)N[C@@H](C)CNc1nccc(-c2cn(C(C)C)nc2-c2cc(Cl)cc(NS(C)(=O)=O)c2)n1 CHEMBL3942604 IC50 0.8 nM
COC(=O)N[C@H](C)CNc1nccc(-c2cn(C(C)C)nc2-c2cc(Cl)cc(NS(C)(=O)=O)c2F)n1 CHEMBL3939997 IC50 0.8 nM
COC(=O)N[C@@H](C)CNc1nccc(-c2c[nH]nc2-c2cc(Cl)cc(NS(C)(=O)=O)c2F)n1 CHEMBL3893988 IC50 0.8 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N)nc(N2CCOCC2)c1 CHEMBL3919205 IC50 0.802 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)nc(NC(CO)CO)n1 CHEMBL3963090 IC50 0.816 nM
CNc1nc(-c2cc(NC(=O)c3cccc(C(F)(F)F)c3)ccc2C)cc(N2CCOCC2)n1 CHEMBL3969555 IC50 0.83 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)nc(N2CCS(=O)(=O)CC2)n1 CHEMBL3969121 IC50 0.837 nM
O/N=C1\CCc2cc(-c3cn(CC4CCCNC4)nc3-c3ccncc3)ccc21 CHEMBL524445 IC50 0.85 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)nc(S(C)(=O)=O)n1 CHEMBL3972141 IC50 0.86 nM
Cc1ccc(NC(=O)c2ccnc(C(C)(F)F)c2)cc1-c1cc(N2CCOCC2)c(=O)n(C)c1 CHEMBL3945935 IC50 0.862 nM
OCC(O)Cn1cc(-c2ccc3c(c2)CC/C3=N\O)c(-c2ccncc2)n1 CHEMBL498317 IC50 0.87 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CC3CCC(C2)O3)nc(N2CCOCC2)n1 CHEMBL3955103 IC50 0.884 nM
CCCS(=O)(=O)Nc1cc(Cl)cc(-c2[nH]c(C3CC3)nc2-c2ccnc(NC[C@H](C)NC(=O)OC)n2)c1F CHEMBL3651627 IC50 0.89 nM
CCCS(=O)(=O)Nc1ccc(Cl)c(NC(=O)c2csc3c(N)ncnc23)c1F CHEMBL2047877 pIC50 0.8913 nM
CN(C)CCOc1ccc(-c2cc(-c3ccncc3)c(-c3ccc4c(c3)CC/C4=N\O)o2)cc1 CHEMBL1964266 Kd 0.9 nM
CN1C2CCC1CN(c1ccc(-c3ccnc4c(-c5cccc(O)c5)c(-c5ccncc5)nn34)cc1)C2 CHEMBL1080476 IC50 0.9 nM
CC(C)c1nc(-c2cc(F)cc(NS(=O)(=O)c3c(F)cccc3F)c2)c(-c2ccnc(Nc3ccc(N4CCOCC4)nc3)n2)s1 CHEMBL1808263 IC50 0.9 nM
COc1n[nH]c2ncc(NC(=O)c3cccc(NC(=O)c4cccc(C(C)(C)C#N)c4)c3)cc12 CHEMBL2153514 IC50 0.9 nM
CC(=O)Nc1cn2cc(-c3cc(NC(=O)c4cc(C(F)(F)F)ccn4)ccc3C)ccc2n1 CHEMBL4204192 IC50 0.9 nM
Cc1ccc(NC(=O)c2ccnc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)c(=O)n(C)c1 CHEMBL3909119 IC50 0.905 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc2nccn2c(N2CCOCC2)n1 CHEMBL3927963 IC50 0.941 nM
COC(=O)N[C@@H](C)CNc1nccc(-c2cn(C(C)C)nc2-c2cc(C)cc(NS(C)(=O)=O)c2F)n1 CHEMBL3929909 IC50 0.95 nM
COC(=O)N[C@@H](C)CNc1nccc(-c2nc(C3CC3)[nH]c2-c2cc(C)cc(NS(=O)(=O)C(C)C)c2)n1 CHEMBL3651698 IC50 0.96 nM
O=C(NCCNc1nccc(-c2c(-c3cccc(O)c3)nc3sccn23)n1)c1ccccc1 CHEMBL1915474 IC50 0.978 nM
O=S(=O)(NCCCNc1nccc(-c2c(-c3cccc(O)c3)nc3sccn23)n1)c1cccc(F)c1 CHEMBL5086749 IC50 0.98 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1nc(N2CCOCC2)nc(N2CCOCC2)c1C CHEMBL3903274 IC50 0.994 nM
CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1 CHEMBL1336 IC50 1.0 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1NC(=O)c1ccc2nccnc2c1 CHEMBL475431 IC50 1.0 nM
CSc1cc(Oc2ccnc3[nH]c(=O)[nH]c23)ccc1NC(=O)Nc1ccc(Cl)c(C(F)(F)F)c1 CHEMBL496201 IC50 1.0 nM
CSc1cc(Oc2ccnc3[nH]c(=O)[nH]c23)ccc1NC(=O)Nc1cccc(C(F)(F)F)c1 CHEMBL496009 IC50 1.0 nM
CCOC(=O)N1C2CCC1CC(c1ccnc3c(-c4cccc(O)c4)c(-c4ccncc4)nn13)C2 CHEMBL571129 IC50 1.0 nM
Oc1cccc(-c2c(-c3ccncc3)nn3c(-c4ccc(N[C@H]5CN6CCC5CC6)cc4)ccnc23)c1 CHEMBL1086871 IC50 1.0 nM
COc1cc(-c2c(-c3ccncc3)nn3c(-c4ccc(N5C[C@@H]6C[C@H]5CN6C)cc4C)ccnc23)ccc1F CHEMBL1076233 IC50 1.0 nM
CN1C[C@@H]2C[C@H]1CN2c1ccc(-c2ccnc3c(-c4cccc5[nH]ncc45)c(-c4ccncc4)nn23)c2ccccc12 CHEMBL1276176 IC50 1.0 nM
Oc1cccc2cc(Nc3c(-c4ncccn4)oc4cnccc34)ccc12 CHEMBL1667910 IC50 1.0 nM
COc1n[nH]c2ncc(NC(=O)c3c(F)ccc(NS(=O)(=O)c4cc(F)ccc4F)c3F)cc12 CHEMBL1822259 IC50 1.0 nM
NC(=O)c1sc2ncnc(-c3cccc(NC(=O)Nc4ccc(C(F)(F)F)cc4)c3)c2c1N CHEMBL1934650 IC50 1.0 nM
CNC(=O)c1cc(Oc2ccc3nc(Nc4ccc(C(C)C)cc4)ncc3c2)ccn1 CHEMBL1950893 IC50 1.0 nM
COc1n[nH]c2ncc(NC(=O)c3cc(NC(=O)c4cccc(C(C)(C)C#N)c4)ccc3F)cc12 CHEMBL2153513 IC50 1.0 nM
Cc1ccc2c(Nc3ccc(Cl)cc3)nccc2c1Nc1ncccc1-c1ncnc2[nH]cnc12 CHEMBL1197798 Ki 1.0 nM
CC(C)c1nc(-c2cccc(NS(=O)(=O)c3c(F)cccc3F)c2)c(-c2ccnc(NCCS(C)(=O)=O)n2)s1 CHEMBL2337915 IC50 1.0 nM
CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]c(-c4cccc(C(F)(F)F)c4)nc3c2)c1F CHEMBL2436796 IC50 1.0 nM
CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]c(-c4ccccc4)cc3c2)c1F CHEMBL2436919 IC50 1.0 nM
O=S(=O)(Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F)c1ccoc1 CHEMBL3354844 IC50 1.0 nM
CC(=O)Nc1cc(Oc2ccc3c(c2)nc(Nc2ccc(OC(F)(F)F)cc2)n3C)ccn1 CHEMBL3335379 IC50 1.0 nM
CC(=O)Nc1cc(Oc2ccc3c(c2)nc(Nc2cc(C(F)(F)F)ccc2F)n3C)ccn1 CHEMBL3335381 IC50 1.0 nM
CCc1ccc(Nc2nc3cc(Oc4ccnc(NC(C)=O)c4)ccc3n2C)cc1 CHEMBL3335377 IC50 1.0 nM
CNc1cc2c(cn1)cc(-c1ccc(F)c(NC(=O)Nc3cc(C(C)(C)C)no3)c1)c(=O)n2[C@H]1CCOC1 CHEMBL3577114 IC50 1.0 nM
CNS(=O)(=O)c1cccc(Nc2ncnc3[nH]cc(-c4cccc(Cl)c4)c23)c1 CHEMBL3613177 IC50 1.0 nM
CNS(=O)(=O)c1cccc(Nc2ncnc3[nH]c(-c4ccccc4)cc23)c1 CHEMBL3613184 IC50 1.0 nM
CNS(=O)(=O)c1cccc(Nc2ncnc3[nH]c(-c4cccc(C)c4)cc23)c1 CHEMBL3613186 IC50 1.0 nM
CNS(=O)(=O)c1cccc(Nc2ncnc3[nH]c(-c4ccc(C)cc4)cc23)c1 CHEMBL3613187 IC50 1.0 nM
CNS(=O)(=O)c1cccc(Nc2ncnc3[nH]c(-c4ccc(O)cc4)cc23)c1 CHEMBL3613189 IC50 1.0 nM
CNS(=O)(=O)c1cccc(Nc2ncnc3[nH]c(-c4ccncc4)cc23)c1 CHEMBL3613190 IC50 1.0 nM
O=S(=O)(Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F)c1cccnc1 CHEMBL3798195 IC50 1.0 nM
O=S(=O)(Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F)c1nccs1 CHEMBL3800081 IC50 1.0 nM
COC(=O)N[C@@H](C)CNc1nccc(-c2cn(C(C)C)nc2-c2cc(C)cc(NS(C)(=O)=O)c2Cl)n1 CHEMBL3933474 IC50 1.0 nM
CCCS(=O)(=O)Nc1cc(F)cc(-c2[nH]c(C3CC3)nc2-c2ccnc(NCC)n2)c1Cl CHEMBL3651649 IC50 1.0 nM
COC(=O)N[C@@H](C)CNc1nccc(-c2nc(C3CC3)[nH]c2-c2cc(Cl)cc(NS(=O)(=O)c3ccc(F)cc3)c2F)n1 CHEMBL3651653 IC50 1.0 nM
CC1(c2nc(-c3ccnc(NCCC#N)n3)c(-c3cccc(NS(C)(=O)=O)c3Cl)[nH]2)CC1 CHEMBL3651659 IC50 1.0 nM
COC(=O)N[C@@H](C)CNc1nccc(-c2nc(C3CCC3)[nH]c2-c2cc(F)cc(NS(C)(=O)=O)c2Cl)n1 CHEMBL3651677 IC50 1.0 nM
CNc1nccc(-c2nc(C3CC3)[nH]c2-c2cc(F)cc(NS(=O)(=O)c3c(F)cccc3F)c2Cl)n1 CHEMBL3651678 IC50 1.0 nM
Nc1nccc(-c2nc(C3CC3)[nH]c2-c2cccc(NS(=O)(=O)c3c(F)cccc3F)c2Cl)n1 CHEMBL3651689 IC50 1.0 nM
O=S(=O)(Nc1cc(F)cc(-c2[nH]c(C3CC3)nc2-c2ccncn2)c1Cl)c1c(F)cccc1F CHEMBL3651690 IC50 1.0 nM
CCCS(=O)(=O)Nc1cccc(-c2[nH]c(C3CC3)nc2-c2ccnc(NC[C@H](C)NC(=O)OC)n2)c1 CHEMBL3651704 IC50 1.0 nM
COC(=O)N[C@@H](C)CNc1nccc(-c2nc(C(C)(C)C)[nH]c2-c2cc(F)cc(NS(C)(=O)=O)c2Cl)n1 CHEMBL3651637 IC50 1.0 nM
CCCS(=O)(=O)Nc1cc(F)cc(-c2[nH]c(C(C)(C)C)nc2-c2ccnc(NC[C@H](C)NC(=O)OC)n2)c1Cl CHEMBL3651638 IC50 1.0 nM
COC(=O)N[C@@H](C)CNc1nccc(-c2nc(C3(C)CC3)[nH]c2-c2cc(Cl)cc(NS(C)(=O)=O)c2F)n1 CHEMBL3651642 IC50 1.0 nM
COC(=O)N[C@@H](C)CNc1nccc(-c2nc(C3(C)CC3)[nH]c2-c2cc(C)cc(NS(C)(=O)=O)c2F)n1 CHEMBL3651643 IC50 1.0 nM
COC(=O)N[C@@H](C)CNc1nccc(-c2nc(C3(C)CC3)[nH]c2-c2cccc(NS(C)(=O)=O)c2Cl)n1 CHEMBL3651645 IC50 1.0 nM
Cc1ccc(C(=O)Nc2cc(C(C)(C)C)on2)cc1Nc1ncnc2c(N)nc(N3CCN(C4CCN(C)CC4)CC3)nc12 CHEMBL3689909 IC50 1.0 nM
Cc1ccc(C(=O)Nc2cc(C(C)(C)C)on2)cc1Nc1ncnc2c(N)nc(N3CCCN(C)CC3)nc12 CHEMBL3689910 IC50 1.0 nM
COc1ccc(NC(=O)c2ccc(C)c(Nc3ncnc4c(N)nc(N5CCN(C6CCN(C)CC6)CC5)nc34)c2)cc1C(F)(F)F CHEMBL3689914 IC50 1.0 nM
COc1ccc(NC(=O)c2ccc(C)c(Nc3ncnc4c(N)nc(N5CCN(CC6CCN(C)CC6)CC5)nc34)c2)cc1C(F)(F)F CHEMBL3689915 IC50 1.0 nM
COc1ccc(NC(=O)c2ccc(C)c(Nc3ncnc4c(N)nc(N5CCCN(C)CC5)nc34)c2)cc1C(F)(F)F CHEMBL3689916 IC50 1.0 nM
Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1ncnc2c(N)nc(N3CCCN(C4CC4)CC3)nc12 CHEMBL3694015 IC50 1.0 nM
Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1ncnc2c(N)nc(N3CCCNCC3)nc12 CHEMBL3694016 IC50 1.0 nM
Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1ncnc2c(N)nc(N3CCCN(c4ncccn4)CC3)nc12 CHEMBL3694020 IC50 1.0 nM
Cc1ccc(C(=O)Nc2cc(N(C)CCN(C)C)cc(C(F)(F)F)c2)cc1Nc1ncnc2c(N)nc(N3CCOCC3)nc12 CHEMBL3694033 IC50 1.0 nM
COc1ccc(NC(=O)c2ccc(Cl)c(Nc3ncnc4cnc(N5CCCN(C)CC5)nc34)c2)cc1C(F)(F)F CHEMBL3694070 IC50 1.0 nM
COc1ccc(C(=O)Nc2ccc(OC)c(C(F)(F)F)c2)cc1Nc1ncnc2cnc(N3CCCCCC3)nc12 CHEMBL3694082 IC50 1.0 nM
COc1ccc(NC(=O)c2ccc(F)c(Nc3ncnc4cnc(N5CCCCCC5)nc34)c2)cc1C(F)(F)F CHEMBL3694095 IC50 1.0 nM
COc1ccc(NC(=O)c2ccc(F)c(Nc3ncnc4cnc(N(C)CCN5CCCC5)nc34)c2)cc1C(F)(F)F CHEMBL3694096 IC50 1.0 nM
COc1ccc(NC(=O)c2ccc(F)c(Nc3ncnc4cnc(N(C)C)nc34)c2)cc1C(F)(F)F CHEMBL3694104 IC50 1.0 nM
CC(C)(C)c1cc(NC(=O)c2ccc(Cl)c(Nc3ncnc4cnc(NCCCN5CCOCC5)nc34)c2)no1 CHEMBL3694137 IC50 1.0 nM
CC(C)(C)c1cc(NC(=O)c2ccc(Cl)c(Nc3ncnc4cnc(N5CCOCC5)nc34)c2)no1 CHEMBL3694138 IC50 1.0 nM
CN(C)CCN(C)c1ncc2ncnc(Nc3cc(C(=O)Nc4cc(C(C)(C)C)on4)ccc3Cl)c2n1 CHEMBL3694142 IC50 1.0 nM
CN(C)CCNc1ncc2ncnc(Nc3cc(C(=O)Nc4cc(C(C)(C)C)on4)ccc3F)c2n1 CHEMBL3694154 IC50 1.0 nM
CC(C)(C)c1cc(NC(=O)c2ccc(F)c(Nc3ncnc4cnc(NCCN5CCOCC5)nc34)c2)no1 CHEMBL3694155 IC50 1.0 nM
CN(C)c1ncc2ncnc(Nc3cc(C(=O)Nc4cc(C(C)(C)C)on4)ccc3F)c2n1 CHEMBL3694156 IC50 1.0 nM
Cc1ccc(C(=O)Nc2cc(CN3CCCC3)cc(C(F)(F)F)c2)cc1Nc1ncnc2cnc(NCCF)nc12 CHEMBL3694163 IC50 1.0 nM
Cc1ccc(C(=O)Nc2cc(CN3CCCC3)cc(C(F)(F)F)c2)cc1Nc1ncnc2cnc(NCC3CCOC3)nc12 CHEMBL3694166 IC50 1.0 nM
Cc1ccc(C(=O)Nc2cc(CN3CCCC3)cc(C(F)(F)F)c2)cc1Nc1ncnc2cnc(NCc3cccnc3)nc12 CHEMBL3694169 IC50 1.0 nM
COCCNc1ncc2ncnc(Nc3cc(C(=O)Nc4cc(CN5CCCC5)cc(C(F)(F)F)c4)ccc3C)c2n1 CHEMBL3694172 IC50 1.0 nM
Cc1ccc(C(=O)Nc2cc(OCCN(C)C)cc(C(F)(F)F)c2)cc1Nc1ncnc2cnc(NCc3ccccc3)nc12 CHEMBL3694209 IC50 1.0 nM
Cc1ccc(C(=O)Nc2cc(OCCN(C)C)cc(C(F)(F)F)c2)cc1Nc1ncnc2cnc(NCc3cccnc3)nc12 CHEMBL3694210 IC50 1.0 nM
COCCNc1ncc2ncnc(Nc3cc(C(=O)Nc4cc(OCCN(C)C)cc(C(F)(F)F)c4)ccc3C)c2n1 CHEMBL3694213 IC50 1.0 nM
COCCNc1ncc2ncnc(Nc3cc(C(=O)Nc4cc(N(C)CCN(C)C)cc(C(F)(F)F)c4)ccc3C)c2n1 CHEMBL3694231 IC50 1.0 nM
Cc1ccc(C(=O)Nc2cc(N(C)CCN(C)C)cc(C(F)(F)F)c2)cc1Nc1ncnc2cnc(NCc3ccncc3)nc12 CHEMBL3697720 IC50 1.0 nM
Cc1ccc(C(=O)Nc2cccc(C(C)(C)C)c2)cc1Nc1ncnc2cnc(N3CCN(C)CC3)nc12 CHEMBL3697775 IC50 1.0 nM
Cc1ccc(C(=O)Nc2cccc(N(C)C)c2)cc1Nc1ncnc2cnc(N3CCCCC3)nc12 CHEMBL3697793 IC50 1.0 nM
Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1ncnc2cnc(N3CCCC3)nc12 CHEMBL3697812 IC50 1.0 nM
Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1ncnc2cnc(N3CC[C@H](F)C3)nc12 CHEMBL3697832 IC50 1.0 nM
Cc1ccc(C(=O)Nc2cccc(OC(F)(F)F)c2)cc1Nc1ncnc2cnc(N3CC[C@H](F)C3)nc12 CHEMBL3697835 IC50 1.0 nM
Cc1ccc(C(=O)Nc2cccc(C(C)(C)C)c2)cc1Nc1ncnc2cnc(N3CCOCC3)nc12 CHEMBL3697839 IC50 1.0 nM
Cc1ccc(C(=O)Nc2ccc(F)c(C(F)(F)F)c2)cc1Nc1ncnc2cnc(N3CCN(C)CC3)nc12 CHEMBL3697842 IC50 1.0 nM
Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1ncnc2cnc(N3CCN(C)CC3)nc12 CHEMBL3697843 IC50 1.0 nM
Cc1ccc(C(=O)Nc2cccc(C(C)(C)C#N)c2)cc1Nc1ncnc2cnc(N3CCOCC3)nc12 CHEMBL3697866 IC50 1.0 nM
Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1ncnc2cnc(N3CCNCC3)nc12 CHEMBL3697883 IC50 1.0 nM
Cc1ccc(C(=O)Nc2cc(C(F)(F)F)ccn2)cc1Nc1ncnc2cnc(N3CC[C@H](F)C3)nc12 CHEMBL3697889 IC50 1.0 nM
COc1ccc(C(F)(F)F)cc1NC(=O)c1ccc(C)c(Nc2ncnc3cnc(NC4CCOC4)nc23)c1 CHEMBL3697891 IC50 1.0 nM
COCCNc1ncc2ncnc(Nc3cc(C(=O)Nc4cc(C(C)(C)C)on4)ccc3C)c2n1 CHEMBL3697901 IC50 1.0 nM
Cc1ccc(C(=O)Nc2cc(C(C)(C)C)on2)cc1Nc1ncnc2cnc(N(C)C3CCOC3)nc12 CHEMBL3697907 IC50 1.0 nM
Cc1ccc(C(=O)Nc2cc(C(C)(C)C)on2)cc1Nc1ncnc2cnc(N3CCN(CCN4CCOCC4)CC3)nc12 CHEMBL3697912 IC50 1.0 nM
CC(C)(C#N)c1cccc(NC(=O)c2ccc(F)c(Nc3ncnc4cnc(NC5CCOC5)nc34)c2)c1 CHEMBL3697926 IC50 1.0 nM
CC(C)(C)c1cc(NC(=O)c2ccc(F)c(Nc3ncnc4cnc(N5CCOCC5)nc34)c2)[nH]n1 CHEMBL3697931 IC50 1.0 nM
O=C(Nc1cc(C(F)(F)F)ccn1)c1ccc(F)c(Nc2ncnc3cnc(N4CCOCC4)nc23)c1 CHEMBL3697933 IC50 1.0 nM
CN1CCC(CN2CCN(c3ncc4ncnc(Nc5cc(C(=O)Nc6cc(C(C)(C)C)on6)ccc5F)c4n3)CC2)CC1 CHEMBL3697934 IC50 1.0 nM
CCN1CCN(c2ncc3ncnc(Nc4cc(C(=O)Nc5cc(C(C)(C)C)on5)ccc4F)c3n2)CC1 CHEMBL3641025 IC50 1.0 nM
Cc1ccc(C(=O)Nc2cccc(OC(F)(F)F)c2)cc1Nc1ncnc2cnc(N3CCOCC3)nc12 CHEMBL3641037 IC50 1.0 nM
Cc1ccc(C(=O)Nc2cccc(C(C)(C)C)c2)cc1Nc1ncnc2cnc(N3CCN(CC4CCN(C)CC4)CC3)nc12 CHEMBL3641043 IC50 1.0 nM
COc1ccc(NC(=O)c2ccc(C)c(Nc3ncnc4cnc(N5CCN(CC6CCN(C)CC6)CC5)nc34)c2)cc1C(F)(F)F CHEMBL3641046 IC50 1.0 nM
Cc1ccc(C(=O)Nc2cc(C(C)(C)C)on2)cc1Nc1ncnc2cnc(N3CCN(CC4CCN(C)CC4)CC3)nc12 CHEMBL3641047 IC50 1.0 nM
COc1ccc(NC(=O)c2ccc(C)c(Nc3ncnc4cnc(N5CCC(N(C)C)CC5)nc34)c2)cc1C(F)(F)F CHEMBL3641061 IC50 1.0 nM
Cc1ccc(C(=O)Nc2cc(N(C)CCN(C)C)cc(C(F)(F)F)c2)cc1Nc1ncnc2cnc(N3CCOCC3)nc12 CHEMBL3641068 IC50 1.0 nM
COc1ccc(NC(=O)c2ccc(C)c(Nc3ncnc4cnc(N5CCCN(C)CC5)nc34)c2)cc1C(F)(F)F CHEMBL3641069 IC50 1.0 nM
Cc1ccc(C(=O)Nc2cc(N3CCCN(C)CC3)cc(C(F)(F)F)c2)cc1Nc1ncnc2cnc(N3CC[C@H](F)C3)nc12 CHEMBL3641081 IC50 1.0 nM
Cc1ccc(C(=O)Nc2cc(N3CCN(C)CC3)cc(C(F)(F)F)c2)cc1Nc1ncnc2cnc(N3CCOCC3)nc12 CHEMBL3641085 IC50 1.0 nM
COCCN(C)c1ncc2ncnc(Nc3cc(C(=O)Nc4ccc(OC)c(C(F)(F)F)c4)ccc3C)c2n1 CHEMBL3641094 IC50 1.0 nM
COCCN(C)c1ncc2ncnc(Nc3cc(C(=O)Nc4cc(C(C)(C)C)on4)ccc3C)c2n1 CHEMBL3641095 IC50 1.0 nM
Cc1ccc(C(=O)Nc2cc(C(C)(C)C)on2)cc1Nc1ncnc2cnc(N3CCN(CCCN4CCCC4)CC3)nc12 CHEMBL3641097 IC50 1.0 nM
Cc1ccc(C(=O)Nc2cc(C(C)(C)C)on2)cc1Nc1ncnc2cnc(N3CCN(CC4CCCN(C)C4)CC3)nc12 CHEMBL3641099 IC50 1.0 nM
Cc1ccc(C(=O)Nc2cc(C(C)(C)C)on2)cc1Nc1ncnc2cnc(N3CCC(N4CCOCC4)CC3)nc12 CHEMBL3641105 IC50 1.0 nM
Cc1ccc(C(=O)Nc2cc(N3CCN(C)CC3)c(F)c(C(F)(F)F)c2)cc1Nc1ncnc2cnc(N3CCOCC3)nc12 CHEMBL3641118 IC50 1.0 nM
Cc1cn(-c2cc(NC(=O)c3ccc(C)c(Nc4ncnc5cnc(NC6CCOC6)nc45)c3)cc(C(F)(F)F)c2)cn1 CHEMBL3641122 IC50 1.0 nM
Cc1ccc(C(=O)Nc2cc(C(C)(C)C)nn2C)cc1Nc1ncnc2cnc(N3CCOCC3)nc12 CHEMBL3641128 IC50 1.0 nM
Cc1ccc(C(=O)Nc2cc(N3CCCN(C)CC3)cc(C(F)(F)F)c2)cc1Nc1ncnc2cnc(N(C)CCF)nc12 CHEMBL3641129 IC50 1.0 nM
Cc1ccc(C(=O)Nc2cc(OCCN3CCCC3)cc(C(F)(F)F)c2)cc1Nc1ncnc2cnc(N3CCOCC3)nc12 CHEMBL3641138 IC50 1.0 nM
COCCN1CCN(c2ncc3ncnc(Nc4cc(C(=O)Nc5ccc(F)c(C(F)(F)F)c5)ccc4C)c3n2)CC1 CHEMBL3641151 IC50 1.0 nM
COc1ccc(NC(=O)c2ccc(C)c(Nc3ncnc4cnc(NCC5CCCCO5)nc34)c2)cc1C(F)(F)F CHEMBL3641159 IC50 1.0 nM
COc1ccc(NC(=O)c2ccc(C)c(Nc3ncnc4cnc(N5CCCOCC5)nc34)c2)cc1C(F)(F)F CHEMBL3641166 IC50 1.0 nM
COc1ccc(NC(=O)c2ccc(C)c(Nc3ncnc4cnc(N(C)C5CCN(C)C5)nc34)c2)cc1C(F)(F)F CHEMBL3641178 IC50 1.0 nM
COc1ncc2ncnc(Nc3cc(C(=O)Nc4cccc(C(F)(F)F)c4)ccc3C)c2n1 CHEMBL3641181 IC50 1.0 nM
COc1ncc2ncnc(Nc3cc(C(=O)Nc4cc(CN5CCCC5)cc(C(F)(F)F)c4)ccc3C)c2n1 CHEMBL3641185 IC50 1.0 nM
Cc1ccc(C(=O)Nc2cc(C(C)(C)C)nn2C)cc1Oc1ncnc2cnc(N3CCOCC3)nc12 CHEMBL3641195 IC50 1.0 nM
COc1ccc(NC(=O)c2ccc(C)c(Nc3ncnc4cnc(NC5CC(N6CCN(C)CC6)C5)nc34)c2)cc1C(F)(F)F CHEMBL3641197 IC50 1.0 nM
COCCN1CCC(Nc2ncc3ncnc(Nc4cc(C(=O)Nc5cc(C(C)(C)C)on5)ccc4C)c3n2)CC1 CHEMBL3641198 IC50 1.0 nM
Cc1ccc(C(=O)Nc2ccnc(C(C)(C)C)c2)cc1Nc1ncnc2cnc(NC3CCN(C)CC3)nc12 CHEMBL3641199 IC50 1.0 nM
COc1ccc(NC(=O)c2ccc(C)c(Nc3ncnc4cnc(N5CCC(CN(C)C)CC5)nc34)c2)cc1C(F)(F)F CHEMBL3641203 IC50 1.0 nM
Cc1ccc(C(=O)Nc2cc(C(C)(C)C)on2)cc1Nc1ncnc2cnc(N3CCC4(CCN(C)C4)C3)nc12 CHEMBL3641207 IC50 1.0 nM
Cc1ccc(C(=O)Nc2ccc3c(c2)OC(F)(F)C(F)(F)O3)cc1Nc1ncnc2cnc(N3CCN(CCN(C)C)CC3)nc12 CHEMBL3641211 IC50 1.0 nM
Cc1ccc(NC(=O)c2cccc(C(C)(C)C#N)c2)cc1Nc1ncnc2cnc(N3CCN(C)CC3)nc12 CHEMBL3641218 IC50 1.0 nM
Cc1ccc(NC(=O)c2cccc(C(C)(C)C#N)c2)cc1Nc1ncnc2cnc(N(C)C)nc12 CHEMBL3641220 IC50 1.0 nM
CCN1CCN(c2ncc3ncnc(Nc4cc(NC(=O)c5cccc(C(C)(C)C#N)c5)ccc4C)c3n2)CC1 CHEMBL3641228 IC50 1.0 nM
Cc1ccc(NC(=O)c2cccc(C(C)(C)C#N)c2)cc1Nc1ncnc2cnc(NC3CCN(C)CC3)nc12 CHEMBL3641229 IC50 1.0 nM
Cc1ccc(NC(=O)c2cccc(C(C)(C)C#N)c2)cc1Nc1ncnc2cnc(N(C)C3CCN(C)CC3)nc12 CHEMBL3641230 IC50 1.0 nM
Cc1ccc(NC(=O)c2cccc(C(C)(C)C#N)c2)cc1Nc1ncnc2cnc(NC3CCOC3)nc12 CHEMBL3641231 IC50 1.0 nM
Cc1ccc(NC(=O)c2cccc(C(C)(C)C#N)c2)cc1Nc1ncnc2cnc(N(C)C3CCOC3)nc12 CHEMBL3641237 IC50 1.0 nM
CNc1ncnc2c(Nc3cc(C(=O)Nc4cc(C(C)(C)C)on4)ccc3C)ncnc12 CHEMBL3643299 IC50 1.0 nM
O=S(=O)(Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F)c1ccco1 CHEMBL3963766 IC50 1.0 nM
COCCCN1CCN(c2cncc(-c3cn(-c4cc(NC(=O)c5ccc(C(C)(C)C)o5)ccc4C)nn3)c2)CC1 CHEMBL3927546 IC50 1.0 nM
Cc1ccc(NC(=O)c2ccc(C(C)(C)C)o2)cc1-n1cc(-c2cncc(N3CCNCC3)c2)nn1 CHEMBL3898292 IC50 1.0 nM
Cc1ccc(C(=O)Nc2ccc(Cl)c(C(F)(F)F)c2)cc1NC(=O)C1(c2ncnc3[nH]cnc23)CC1 CHEMBL4466555 IC50 1.0 nM
O=S(=O)(NCCNc1nccc(-c2c(-c3cccc(O)c3)nc3sccn23)n1)c1ccc(F)cc1 CHEMBL5083036 IC50 1.0 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(OC2CCOCC2)nc(N2CCOCC2)n1 CHEMBL3906652 IC50 1.001 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cncc(N2CCOCC2)n1 CHEMBL3889721 IC50 1.003 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cnc(O[C@H](C)C#N)c(N2CCOCC2)c1 CHEMBL4111816 IC50 1.023 nM
Cc1ccc(C(=O)Nc2cccc(F)c2)cc1Nc1ncccc1-c1ncnc2[nH]cnc12 CHEMBL3354383 IC50 1.03 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc2[nH]cnc2c(N2CCOCC2)n1 CHEMBL3924576 IC50 1.067 nM
COc1ncc(-c2cc(NC(=O)c3cccc(C(F)(F)F)c3)ccc2C)cc1N1CCOCC1 CHEMBL3956383 IC50 1.07 nM
COC(=O)N[C@@H](C)CNc1nccc(-c2nc(C(C)(C)C)[nH]c2-c2cccc(NS(=O)(=O)CCC(F)(F)F)c2F)n1 CHEMBL3651699 IC50 1.08 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1ccnc(N2CCOCC2)c1 CHEMBL3912148 IC50 1.08 nM
CCCS(=O)(=O)Nc1ccc(F)c(NC(=O)c2csc3c(N)ncnc23)c1Cl CHEMBL2047878 pIC50 1.096 nM
CCOC(=O)c1oc2cnccc2c1Nc1ccc2c(O)cccc2c1 CHEMBL1667906 IC50 1.1 nM
CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]c(-c4ccc(OC)cc4)nc3c2)c1F CHEMBL2436789 IC50 1.1 nM
CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]c(-c4cccc(Cl)c4)nc3c2)c1F CHEMBL2436806 IC50 1.1 nM
CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]c(-c4ccc(F)cc4)cc3c2)c1F CHEMBL2436921 IC50 1.1 nM
COC(=O)N[C@@H](C)CNc1nccc(-c2cn(C(C)C)nc2-c2cc(F)cc(NS(C)(=O)=O)c2Cl)n1 CHEMBL3904633 IC50 1.1 nM
COC(=O)N[C@@H](C)CNc1nccc(-c2nc(C3CC3)[nH]c2-c2cc(C)cc(NS(C)(=O)=O)c2Cl)n1 CHEMBL3651632 IC50 1.1 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCCOCC2)nc(N2CCOCC2)n1 CHEMBL3959652 IC50 1.131 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(-c2cnn(C)c2)nc(N2CCOCC2)c1 CHEMBL3905047 IC50 1.137 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)nc(N2CCOCC2)c1 CHEMBL3960436 IC50 1.142 nM
COCCn1cc(-c2ccc3c(c2)CC/C3=N\O)c(-c2ccncc2)n1 CHEMBL496472 IC50 1.16 nM
Cc1ncc(NC(=O)c2cccc(C(F)F)c2)cc1-c1ccnc(N2CCOCC2)c1 CHEMBL3960515 IC50 1.17 nM
Cc1ccc(NC(=O)c2cc(C(C)(C)C)on2)cc1-c1cc(N2CCOCC2)nc(N2CCOCC2)n1 CHEMBL3932011 IC50 1.197 nM
O/N=C1\CCc2cc(-c3cn(CC4CCNCC4)nc3-c3ccncc3)ccc21 CHEMBL497670 IC50 1.2 nM
Fc1cc(CN2C[C@@H]3C[C@H]2CO3)ccc1-c1ccnc2c(-c3cccc4[nH]ncc34)c(-c3ccncc3)nn12 CHEMBL1276189 IC50 1.2 nM
CN1C[C@@H]2C[C@H]1CN2c1ccc(-c2ccnc3c(-c4cccc5[nH]ncc45)c(-c4ccncc4)nn23)cc1 CHEMBL1278218 IC50 1.2 nM
CC(C)c1nc(-c2cccc(NS(=O)(=O)c3c(F)cccc3F)c2)c(-c2ccnc(Nc3ccc(N4CCOCC4)nc3)n2)s1 CHEMBL1808261 IC50 1.2 nM
COc1n[nH]c2ncc(NC(=O)c3cc(NC(=O)c4cccc(C(C)(C)C#N)c4)ccc3Cl)cc12 CHEMBL2153635 IC50 1.2 nM
CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]c(-c4cccc(OC)c4)nc3c2)c1F CHEMBL2436795 IC50 1.2 nM
COc1cccc(C(=O)Nc2ccc(C)c(Nc3ncccc3-c3ncnc4[nH]cnc34)c2)c1 CHEMBL3354839 IC50 1.2 nM
CCn1c(=O)c(-c2ccc(F)c(NC(=O)Nc3cc(C(C)(C)C)no3)c2)cc2cnc(NC)cc21 CHEMBL3577115 IC50 1.2 nM
O=C1CCc2c(Oc3ccc4c(c3)C3C(O4)C3c3nc4cc5c(cc4[nH]3)CCC5)ccnc2N1 CHEMBL3896243 IC50 1.2 nM
CC1(C)OC(c2ccnc(N)n2)=C(c2cc(Cl)cc(NS(=O)(=O)c3cccc(F)c3)c2F)C1=O CHEMBL3975151 IC50 1.2 nM
Cc1ccc(C(=O)Nc2ccc(Cl)cc2)cc1NC(=O)C1(c2ncnc3[nH]ccc23)CC1 CHEMBL4545914 IC50 1.2 nM
COc1ccc(S(=O)(=O)NCCCCNc2nccc(-c3c(-c4cccc(N)c4)nc4sccn34)n2)cc1 CHEMBL4795335 IC50 1.2 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1c[nH]c(=O)c(N2CCOCC2)n1 CHEMBL3971301 IC50 1.214 nM
Cc1ncc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1ccnc(N2CCOCC2)c1 CHEMBL3928581 IC50 1.241 nM
F[C@H]1CNCC[C@@H]1n1cc(-c2ccc3c(c2)Cc2c[nH]nc2-3)c(-c2ccncc2)n1 CHEMBL1780180 IC50 1.25 nM
Cc1ccc(NC(=O)c2cccc(C(F)F)c2)cc1-c1cc(N2CCOCC2)c(=O)n(C)c1 CHEMBL3894542 IC50 1.254 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)nc(N2CCCC2=O)n1 CHEMBL3903846 IC50 1.277 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cn(CC(F)F)c(=O)c(N2CCOCC2)n1 CHEMBL3946071 IC50 1.278 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cn2ccnc2c(N2CCOC[C@H]2C)n1 CHEMBL4108504 IC50 1.286 nM
O/N=C1/CCc2cc(-c3[nH]c(-c4ccccc4)nc3-c3ccncc3)ccc21 CHEMBL372543 Kd 1.3 nM
CN(C)Cc1cccc(NC(=O)c2nc(-c3ccc4c(c3)CC/C4=N\O)c(-c3ccncc3)[nH]2)c1 CHEMBL515322 Kd 1.3 nM
CC(=O)N1CCN(c2ccc(Nc3nccc(-c4sc(C(C)C)nc4-c4cccc(NS(=O)(=O)c5c(F)cccc5F)c4)n3)cn2)CC1 CHEMBL1808260 IC50 1.3 nM
COc1n[nH]c2ncc(NC(=O)c3c(F)ccc(NS(=O)(=O)CCCF)c3F)cc12 CHEMBL1822089 IC50 1.3 nM
COc1n[nH]c2ncc(NC(=O)c3cc(NC(=O)c4ccc(Cl)c(C(F)(F)F)c4)ccc3F)cc12 CHEMBL2153634 IC50 1.3 nM
CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]c(-c4ccc(C)cc4)nc3c2)c1F CHEMBL2436790 IC50 1.3 nM
N#Cc1c(Oc2cccc(NC(=O)Cc3cccc(C(F)(F)F)c3)c2)ccc2nc(NC(=O)C3CC3)sc12 CHEMBL3125888 IC50 1.3 nM
Cc1ccc(C(=O)Nc2cccc(Cl)c2)cc1Nc1ncccc1-c1ncnc2[nH]cnc12 CHEMBL3354385 IC50 1.3 nM
CNS(=O)(=O)c1ccc(N2CCOCC2)c(Nc2ncnc3[nH]cc(C)c23)c1 CHEMBL3613199 IC50 1.3 nM
CNS(=O)(=O)c1ccc(N2CCOCC2)c(Nc2ncnc3[nH]c(-c4cccc(C(F)(F)F)c4)cc23)c1 CHEMBL3613309 IC50 1.3 nM
Nc1nccc(C2=C(c3cc(Cl)cc(NS(=O)(=O)c4c(F)cccc4F)c3F)C(=O)C3(CCCC3)O2)n1 CHEMBL3965702 IC50 1.3 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)nc(N2CC3(COC3)C2)n1 CHEMBL3947016 IC50 1.306 nM
Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2=O)nc(N2CCOCC2)n1 CHEMBL3889893 IC50 1.332 nM
COC(=O)N[C@@H](C)CNc1nccc(-c2nc(C(C)(C)C)[nH]c2-c2cc(Cl)cc(NS(=O)(=O)C(C)C)c2)n1 CHEMBL3651614 IC50 1.35 nM
Cc1ccc(NC(=O)c2cc(C(C)(C)C)no2)cc1-c1cc(N2CCOCC2)nc(N2CCOCC2)n1 CHEMBL3975759 IC50 1.356 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)c2oc(=O)[nH]c2c1 CHEMBL3947696 IC50 1.399 nM
O=C(NCCN1CCOCC1)c1nc(-c2ccc3c(c2)CC/C3=N\O)c(-c2ccncc2)[nH]1 CHEMBL515491 Kd 1.4 nM
CN1C[C@@H]2C[C@H]1CC2c1cc(F)ccc1-c1ccnc2c(-c3cccc4[nH]ncc34)c(-c3ccncc3)nn12 CHEMBL1276182 IC50 1.4 nM
CN1C[C@@H]2C[C@H]1CN2c1ccc(-c2ccnc3c(-c4cccc5[nH]ncc45)c(-c4ccncc4)nn23)c(C(F)(F)F)c1 CHEMBL1276172 IC50 1.4 nM
CC(C)NC(=O)c1oc2cnccc2c1Nc1ccc2c(O)cccc2c1 CHEMBL1667908 IC50 1.4 nM
O=C(Nc1ccncn1)c1oc2cnccc2c1Nc1ccc2c(O)cccc2c1 CHEMBL1614960 IC50 1.4 nM
Oc1cc(Nc2c(-c3ncccn3)oc3cnccc23)ccc1Cl CHEMBL1614963 IC50 1.4 nM
Cn1cc(-c2ccc3c(O)cccc3c2)c(-c2ccncc2)n1 CHEMBL1780161 IC50 1.4 nM
F[C@@H]1CNCC[C@H]1n1cc(-c2ccc3c(c2)Cc2c[nH]nc2-3)c(-c2ccncc2)n1 CHEMBL1780177 IC50 1.4 nM
CCCS(=O)(=O)Nc1ccc(Cl)c(C(=O)Nc2cnc3[nH]nc(OC)c3c2)c1Cl CHEMBL1822069 IC50 1.4 nM
CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]c(-c4ccc(S(C)(=O)=O)cc4)nc3c2)c1F CHEMBL2436794 IC50 1.4 nM
CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]c(-c4ccc(C(F)(F)F)cc4)nc3c2)c1F CHEMBL2436791 IC50 1.4 nM
Cc1ccc(C(=O)Nc2ccc(C(F)(F)F)c(Cl)c2)cc1NC(=O)C1(c2cc(NCCCN3CCN(C)CC3)ncn2)CC1 CHEMBL4282601 IC50 1.4 nM
N[C@H]1CC[C@H](Nc2ncnc3c(C(=O)Nc4c(Cl)ccc(NS(=O)(=O)c5cc(F)ccc5F)c4F)csc23)CC1 CHEMBL4786638 Ki 1.4 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)nc(N)n1 CHEMBL3894913 IC50 1.429 nM
Cc1cc(NC(=O)c2ccc(C)c(Nc3ncccc3-c3ncnc4[nH]cnc34)c2)ccc1Cl CHEMBL3354384 IC50 1.43 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOC[C@H]2CO)nc(N2CCOCC2)n1 CHEMBL4110542 IC50 1.43 nM
Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)nc(N2CCOCC2)n1 CHEMBL3982235 IC50 1.481 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1ccnc(N2CCO[C@H](CO)C2)c1 CHEMBL3980394 IC50 1.49 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2C3CCC2COC3)nc(N2CCOCC2)n1 CHEMBL3903859 IC50 1.495 nM
Cc1ccc(NC(=O)c2ccnc(S(C)(=O)=O)c2)cc1-c1ccnc(N2CCOCC2)c1 CHEMBL3949277 IC50 1.499 nM
Cn1cc(-c2ccc3c(c2)Cc2c[nH]nc2-3)c(-c2ccncc2)n1 CHEMBL523261 IC50 1.5 nM
Oc1cccc(-c2c(-c3ccncc3)nn3c(-c4ccc(N[C@@H]5CN6CCC5CC6)cc4)ccnc23)c1 CHEMBL1087510 IC50 1.5 nM
CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]c(-c4ccc(Cl)c(Cl)c4)nc3c2)c1F CHEMBL2436803 IC50 1.5 nM
Cc1ccc(C(=O)Nc2ccc(C(F)(F)F)cc2)cc1Nc1ncccc1-c1ncnc2[nH]cnc12 CHEMBL3354387 IC50 1.5 nM
Cn1nccc1-c1cc(C(=O)N[C@@H]2CCc3ccc(Oc4ccnc5c4CCC(=O)N5)cc3C2)cc(C(F)(F)F)c1 CHEMBL3764588 IC50 1.5 nM
O=C1Nc2ccc(I)cc2/C1=C/c1cc(Br)c(O)c(Br)c1 CHEMBL72365 IC50 1.5 nM
CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)c(F)c2)ccn1 CHEMBL1946170 IC50 1.5 nM
COc1cccc(-c2nc3sccn3c2-c2ccnc(NCCN3CCN(C)S3(=O)=O)n2)c1 CHEMBL5080553 IC50 1.51 nM
Cc1ccc(NC(=O)c2cccc(C(C)(C)C#N)c2)cc1-c1cc(N2CCOCC2)nc(N2CCOCC2)n1 CHEMBL3968350 IC50 1.521 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)c2nccn2n1 CHEMBL3936964 IC50 1.538 nM
Cc1ccc(NC(=O)c2cncc(N(C)C)c2)cc1-c1cc(N2CCOCC2)c(=O)n(C)c1 CHEMBL3904667 IC50 1.542 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)c(=O)n(C)n1 CHEMBL3927672 IC50 1.575 nM
CCCS(=O)(=O)Nc1ccc(F)c(NC(=O)Nc2ncnc3[nH]nc(OC)c23)c1F CHEMBL2047872 pIC50 1.585 nM
Cc1ccc2c(Nc3ccc(Cl)cc3)nccc2c1Nc1ncccc1-c1ncnc2[nH]cnc12 CHEMBL3215582 IC50 1.6 nM
COC(=O)C1CC2c3c(cnc4c(-c5ccc(Cl)c(O)c5)c(-c5ccncc5)nn34)CC1N2C CHEMBL585148 IC50 1.6 nM
O=C(Nc1ncccn1)c1oc2cnccc2c1Nc1ccc(Cl)c(O)c1 CHEMBL1667914 IC50 1.6 nM
COc1n[nH]c2ncc(NC(=O)c3c(F)ccc(NS(=O)(=O)c4ccccc4)c3F)cc12 CHEMBL1822256 IC50 1.6 nM
CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]c(-c4ccccc4)nc3c2)c1F CHEMBL2436813 IC50 1.6 nM
O=C(Nc1ccc(Cl)c(Cl)c1)c1ccc(Cl)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1 CHEMBL3354391 IC50 1.6 nM
Cc1ccc(NC(=O)c2cccc(C(C)(C)C#N)c2)cc1-c1cc(C2CCOCC2)nc(N2CCOCC2)c1 CHEMBL3933060 IC50 1.626 nM
C=C(C)c1cc(N2CCOCC2)nc(-c2cc(NC(=O)c3cccc(C(F)(F)F)c3)ccc2C)n1 CHEMBL3982146 IC50 1.648 nM
COc1ncc(-c2cc(NC(=O)c3cccc(C(F)(F)F)c3)cnc2C)cc1N1CCOCC1 CHEMBL3978705 IC50 1.667 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(C2CCOCC2)nc(N2CCOCC2)c1 CHEMBL3964430 IC50 1.688 nM
Cc1ccc(C(=O)Nc2cccc(C(C)C)c2)cc1Nc1ncccc1-c1ncnc2[nH]cnc12 CHEMBL3354382 IC50 1.69 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)nc(N2CCC(O)C2)n1 CHEMBL3896660 IC50 1.695 nM
CCCS(=O)(=O)Nc1ccc(Cl)c(C(=O)Nc2cnc3[nH]cc(OC)c3c2)c1F CHEMBL4288883 pIC50 1.698 nM
ON=C1CCc2cc(-c3nc(C4CCNCC4)[nH]c3-c3ccncc3)ccc21 CHEMBL1794071 Kd 1.7 nM
CNc1ncc2cc(-c3cc(C(=O)Nc4cccc(C(F)(F)F)c4)ccc3C)ccc2n1 CHEMBL212964 IC50 1.7 nM
CCCS(=O)(=O)Nc1ccc(Cl)c(C(=O)Nc2cnc3[nH]nc(OC)c3c2)c1F CHEMBL1822068 IC50 1.7 nM
N[C@H](CO)c1cc(C(=O)N[C@@H]2CCc3ccc(Oc4ccnc5c4CCC(=O)N5)cc3C2)cc(C(F)(F)F)c1 CHEMBL3763999 IC50 1.7 nM
CCS(=O)(=O)Nc1c(F)ccc(-c2nn(C(C)C)cc2-c2ccnc(NC[C@H](C)NC(=O)OC)n2)c1F CHEMBL3917262 IC50 1.7 nM
Nc1nccc(-c2sc(C3CCCN3)nc2-c2cccc(NS(=O)(=O)c3cc(F)ccc3F)c2F)n1 CHEMBL5189539 IC50 1.7 nM
Nc1nccc(-c2sc(C3CCCCN3)nc2-c2cccc(NS(=O)(=O)c3cc(F)ccc3F)c2F)n1 CHEMBL5201169 IC50 1.7 nM
Cc1ccc(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1-c1cc(C2CCOCC2)nc(N2CCOCC2)c1 CHEMBL3940053 IC50 1.708 nM
Cc1ccc(NC(=O)c2cccc(Cl)c2)cc1Nc1ncccc1-c1ncnc2[nH]cnc12 CHEMBL3354838 IC50 1.77 nM
COc1n[nH]c2ncc(NC(=O)c3c(F)ccc(NS(=O)(=O)c4ccccc4F)c3F)cc12 CHEMBL1822257 IC50 1.8 nM
CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]nc(I)c3c2)c1F CHEMBL1822242 IC50 1.8 nM
CCCS(=O)(=O)Nc1ccc(F)c(NC(=O)c2cccc3c(N)ncnc23)c1F CHEMBL2047873 IC50 1.8 nM
O=C(c1ccc(F)c(F)c1Nc1ccc(I)cc1F)N1CC(O)([C@@H]2CCCCN2)C1 CHEMBL2146883 IC50 1.8 nM
NC1(c2cc(C(=O)N[C@@H]3CCc4ccc(Oc5ccnc6c5CCC(=O)N6)cc4C3)cc(C(F)(F)F)c2)CCC1 CHEMBL3765012 IC50 1.8 nM
Cc1ccc(NC(=O)c2cccc(S(C)(=O)=O)c2)cc1-c1cc(N2CCOCC2)c(=O)n(C)c1 CHEMBL3923479 IC50 1.819 nM
Cc1ncc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)nc(N2CCOCC2)n1 CHEMBL3953527 IC50 1.82 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)n(C)c(=O)c1 CHEMBL3918750 IC50 1.835 nM
Cc1ccc(NC(=O)c2cncc(C(C)(C)C)c2)cc1-c1cc(N2CCOCC2)nc(N2CCOCC2)n1 CHEMBL3924379 IC50 1.851 nM
Cc1ncc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)nc(OCCO)n1 CHEMBL3900045 IC50 1.853 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)c(=O)n([C@H](C)C#N)c1 CHEMBL4112070 IC50 1.889 nM
CN1C[C@@H]2C[C@H]1CN2c1ccc(-c2ccnc3c(-c4cccc5[nH]ncc45)c(-c4ccncc4)nn23)cc1F CHEMBL1276174 IC50 1.9 nM
COc1n[nH]c2ncc(NC(=O)c3cc(NC(=O)c4cccc(C(C)(C)C#N)c4)ccc3C)cc12 CHEMBL2153636 IC50 1.9 nM
CCNCc1cc(C(=O)N[C@@H]2CCc3ccc(Oc4ccnc5c4CCC(=O)N5)cc3C2)cc(C(F)(F)F)c1 CHEMBL3765509 IC50 1.9 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1c[nH]c(=O)c(N2CCOCC2)c1 CHEMBL3924392 IC50 1.918 nM
Cc1ccc(NC(=O)c2cc(CN(C)C)cc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)nc(N2CCOCC2)n1 CHEMBL3952075 IC50 1.967 nM
CC(C)(C)c1nc(-c2ccc(Cl)c(O)c2)c(-c2ccncc2)[nH]1 CHEMBL200172 Kd 2.0 nM
O=C(Cc1ccc(Cl)cc1)Nc1cccc(-c2nc(C3CC3)[nH]c2-c2ccnc(NCCN3CCNC3=O)n2)c1 CHEMBL429498 IC50 2.0 nM
CNC(=O)c1cc(Oc2ccc3c(c2)nc(Nc2ccc(Br)cc2)n3C)ccn1 CHEMBL513600 IC50 2.0 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1NC(=O)c1ccc2ncccc2c1 CHEMBL481563 IC50 2.0 nM
CCOC(=O)N1C2CCC1CC(c1ccnc3c(-c4cccc5[nH]ncc45)c(-c4ccncc4)nn13)C2 CHEMBL585334 IC50 2.0 nM
Oc1cccc(-c2c(-c3ccncc3)nn3c(-c4ccc(NCC56CCN(CC5)CC6)cc4)ccnc23)c1 CHEMBL1088289 IC50 2.0 nM
CSc1cc(Oc2ccnc3[nH]c(=O)c(=O)[nH]c23)ccc1NC(=O)Nc1cc(C(F)(F)F)ccc1F CHEMBL1214000 IC50 2.0 nM
CSc1cc(Oc2ccnc3[nH]c(=O)c(C)nc23)ccc1NC(=O)Nc1cc(C(F)(F)F)ccc1F CHEMBL1214001 IC50 2.0 nM
CN1C[C@@H]2C[C@H]1CN2c1ccc(-c2ccnc3c(-c4cccc5[nH]ncc45)c(-c4ccncc4)nn23)cc1C(F)(F)F CHEMBL1276175 IC50 2.0 nM
CN1CCN(Cc2cnc(-c3oc4cnccc4c3Nc3ccc4c(O)cccc4c3)nc2)CC1 CHEMBL1667911 IC50 2.0 nM
Fc1ccc(Nc2c(-c3ncccn3)oc3cnccc23)c2cn[nH]c12 CHEMBL1667921 IC50 2.0 nM
CN(C)CCNC(=O)c1oc2cnccc2c1Nc1ccc2c(c1)CC/C2=N\O CHEMBL1668917 IC50 2.0 nM
O[C@@H]1CCC[C@H](n2cc(-c3ccc4c(c3)Cc3c[nH]nc3-4)c(-c3ccncc3)n2)C1 CHEMBL1780173 IC50 2.0 nM
CC(C)(C)c1cccc(Nc2nc3cc(Oc4ccnc(C(N)=O)c4)ccc3s2)c1 CHEMBL1778410 IC50 2.0 nM
O=C(c1ccc(-c2ccc3c(c2)CNC3)s1)N1N=C(c2cccnc2)CC1c1c(O)cccc1F CHEMBL1778670 IC50 2.0 nM
NC(=O)c1sc2nc(NC3CC3)nc(-c3cc(O)cc(Cl)c3)c2c1N CHEMBL1934513 IC50 2.0 nM
CC(C)CS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]nc(C4CC4)c3c2)c1Cl CHEMBL1939072 IC50 2.0 nM
CCCS(=O)(=O)Nc1ccc(F)c(Nc2ccc3ncn(C)c(=O)c3c2)c1Cl CHEMBL3236198 IC50 2.0 nM
CCCS(=O)(=O)Nc1ccc(F)c(Nc2ccc3ncn(-c4cnn(C)c4)c(=O)c3c2)c1Cl CHEMBL3236459 IC50 2.0 nM
CC(C)N1CCC(C(=O)Nc2cc(Oc3ccc4c(c3)nc(Nc3cc(C(F)(F)F)ccc3F)n4C)ccn2)CC1 CHEMBL3335385 IC50 2.0 nM
CNc1ncc2cc(-c3cc(NC(=O)NCCC(C)(C)C)c(F)cc3C)cnc2n1 CHEMBL3577123 IC50 2.0 nM
O=C1CCc2c(Oc3ccc4c(c3)C[C@H](NC(=O)c3cc(-c5cnc[nH]5)cc(C(F)(F)F)c3)CC4)ccnc2N1 CHEMBL3765355 IC50 2.0 nM
O=S(=O)(Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F)C1CCCC1 CHEMBL3800364 IC50 2.0 nM
O=S(=O)(Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F)N1CCCC1 CHEMBL3799949 IC50 2.0 nM
COC(=O)N[C@@H](C)CNc1nccc(-c2cn(C(C)C)nc2-c2cc(Cl)cc(NS(=O)(=O)C3CC3)c2F)n1 CHEMBL3930080 IC50 2.0 nM
CC(C)n1cc(-c2ccnc(NCCC#N)n2)c(-c2cc(Cl)cc(NS(C)(=O)=O)c2F)n1 CHEMBL3894746 IC50 2.0 nM
CCCS(=O)(=O)Nc1cccc(-c2nn(C(C)C)cc2-c2ccnc(NC[C@H](C)NC(=O)OC)n2)c1F CHEMBL3982541 IC50 2.0 nM
CCCS(=O)(=O)Nc1cc(Cl)cc(-c2nn(C(C)C)cc2-c2ccnc(NC[C@H](C)NC(=O)OC)n2)c1F CHEMBL3944081 IC50 2.0 nM
COC(=O)N[C@@H](C)CNc1nccc(-c2nc(-c3ccc(C(F)(F)F)cc3)[nH]c2-c2cc(F)cc(NS(C)(=O)=O)c2Cl)n1 CHEMBL3651682 IC50 2.0 nM
CCCS(=O)(=O)Nc1cccc(-c2[nH]c(C3CC3)nc2-c2ccnc(NCCC(N)=O)n2)c1F CHEMBL3651702 IC50 2.0 nM
Cc1ccc(C(=O)Nc2ccc(C(F)(F)F)cc2)cc1Nc1ncnc2c(N)nc(N3CCN(CC4CCN(C)CC4)CC3)nc12 CHEMBL3689907 IC50 2.0 nM
Cc1ccc(C(=O)Nc2cc(C(C)(C)C)n[nH]2)cc1Nc1ncnc2c(N)nc(N3CCN(C4CCN(C)CC4)CC3)nc12 CHEMBL3689911 IC50 2.0 nM
Cc1ccc(C(=O)Nc2cc(C(C)(C)C)n[nH]2)cc1Nc1ncnc2c(N)nc(N3CCN4CCCC4C3)nc12 CHEMBL3689933 IC50 2.0 nM
Cc1ccc(C(=O)Nc2cc(C(C)(C)C)n[nH]2)cc1Nc1ncnc2c(N)nc(N3C[C@@H](C)N[C@@H](C)C3)nc12 CHEMBL3689934 IC50 2.0 nM
Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1ncnc2c(N)nc(N3CC(C)NC(C)C3)nc12 CHEMBL3694019 IC50 2.0 nM
Cc1ccc(C(=O)Nc2cc(C(C)(C)C)n[nH]2)cc1Nc1ncnc2c(N)nc(N3C[C@@H]4C[C@H]3CN4)nc12 CHEMBL3694026 IC50 2.0 nM
Cc1ccc(C(=O)Nc2cc(C(F)(F)F)ccn2)cc1Nc1ncnc2c(N)nc(N3CCN(C)CC3)nc12 CHEMBL3694030 IC50 2.0 nM
CCN1CCN(c2cc(NC(=O)c3ccc(C)c(Nc4ncnc5c(N)nc(N6CCOCC6)nc45)c3)cc(C(F)(F)F)c2)CC1 CHEMBL3694034 IC50 2.0 nM
Cc1ccc(C(=O)Nc2cccc(C(C)(C)C)c2)cc1Nc1ncnc2c(N)nc(N3CCN(C)CC3)nc12 CHEMBL3694037 IC50 2.0 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1Nc1ncnc2c(N)nc(N3CCN(C4CCN(C)CC4)CC3)nc12 CHEMBL3694053 IC50 2.0 nM
COc1ccc(NC(=O)c2ccc(C)c(Nc3ncnc4cnc(N5CCN(C)CC5)nc34)c2)cc1C(F)(F)F CHEMBL3694064 IC50 2.0 nM
COCCN(C)c1ncc2ncnc(Nc3cc(C(=O)Nc4ccc(OC)c(C(F)(F)F)c4)ccc3Cl)c2n1 CHEMBL3694067 IC50 2.0 nM
COc1ccc(NC(=O)c2ccc(Cl)c(Nc3ncnc4cnc(N(C)CCN(C)C)nc34)c2)cc1C(F)(F)F CHEMBL3694068 IC50 2.0 nM
COc1ccc(NC(=O)c2ccc(Cl)c(Nc3ncnc4cnc(N5CCOCC5)nc34)c2)cc1C(F)(F)F CHEMBL3694075 IC50 2.0 nM
COc1ccc(NC(=O)c2ccc(Cl)c(Nc3ncnc4cnc(N(C)C)nc34)c2)cc1C(F)(F)F CHEMBL3694079 IC50 2.0 nM
COc1ccc(C(=O)Nc2ccc(OC)c(C(F)(F)F)c2)cc1Nc1ncnc2cnc(N3CCOCC3)nc12 CHEMBL3694088 IC50 2.0 nM
COc1ccc(C(=O)Nc2ccc(OC)c(C(F)(F)F)c2)cc1Nc1ncnc2cnc(N(C)C)nc12 CHEMBL3694092 IC50 2.0 nM
COCCN(C)c1ncc2ncnc(Nc3cc(C(=O)Nc4ccc(OC)c(C(F)(F)F)c4)ccc3F)c2n1 CHEMBL3694093 IC50 2.0 nM
COc1ccc(NC(=O)c2ccc(F)c(Nc3ncnc4cnc(N5CCN(C)CC5)nc34)c2)cc1C(F)(F)F CHEMBL3694097 IC50 2.0 nM
COc1ccc(NC(=O)c2ccc(F)c(Nc3ncnc4cnc(NCCN(C)C)nc34)c2)cc1C(F)(F)F CHEMBL3694102 IC50 2.0 nM
COc1ccc(NC(=O)c2ccc(F)c(Nc3ncnc4cnc(NCCN5CCOCC5)nc34)c2)cc1C(F)(F)F CHEMBL3694103 IC50 2.0 nM
CN(C)CCNc1ncc2ncnc(Nc3cc(C(=O)Nc4cc(C(C)(C)C)on4)ccc3Cl)c2n1 CHEMBL3694140 IC50 2.0 nM
CC(C)(C)c1cc(NC(=O)c2ccc(Cl)c(Nc3ncnc4cnc(NCCN5CCOCC5)nc34)c2)no1 CHEMBL3694141 IC50 2.0 nM
COc1ccc(C(=O)Nc2cc(C(C)(C)C)on2)cc1Nc1ncnc2cnc(N3CCOCC3)nc12 CHEMBL3694144 IC50 2.0 nM
COCCN(C)c1ncc2ncnc(Nc3cc(C(=O)Nc4cc(C(C)(C)C)on4)ccc3F)c2n1 CHEMBL3694147 IC50 2.0 nM
COc1ccc(C(=O)Nc2cc(C(C)(C)C)on2)cc1Nc1ncnc2cnc(N3CCN(C)CC3)nc12 CHEMBL3694158 IC50 2.0 nM
COc1ccc(C(=O)Nc2cc(C(C)(C)C)on2)cc1Nc1ncnc2cnc(N3CCCN(C)CC3)nc12 CHEMBL3694159 IC50 2.0 nM
COCCN(C)c1ncc2ncnc(Nc3cc(C(=O)Nc4cc(CN5CCCC5)cc(C(F)(F)F)c4)ccc3C)c2n1 CHEMBL3694160 IC50 2.0 nM
Cc1ccc(C(=O)Nc2cc(CN3CCCC3)cc(C(F)(F)F)c2)cc1Nc1ncnc2cnc(N3CCC(F)CC3)nc12 CHEMBL3694165 IC50 2.0 nM
Cc1ccc(C(=O)Nc2cc(CN3CCCC3)cc(C(F)(F)F)c2)cc1Nc1ncnc2cnc(N3CCCCC3)nc12 CHEMBL3694168 IC50 2.0 nM
Cc1ccc(C(=O)Nc2cc(CN3CCCC3)cc(C(F)(F)F)c2)cc1Nc1ncnc2cnc(N3CCCC3)nc12 CHEMBL3694171 IC50 2.0 nM
Cc1ccc(C(=O)Nc2cc(CN3CCCC3)cc(C(F)(F)F)c2)cc1Nc1ncnc2cnc(NCC(C)C)nc12 CHEMBL3694174 IC50 2.0 nM
Cc1ccc(C(=O)Nc2cc(CN3CCCC3)cc(C(F)(F)F)c2)cc1Nc1ncnc2cnc(NCc3ccccn3)nc12 CHEMBL3694175 IC50 2.0 nM
Cc1ccc(C(=O)Nc2cc(CN3CCCC3)cc(C(F)(F)F)c2)cc1Nc1ncnc2cnc(NCc3ccncc3)nc12 CHEMBL3694176 IC50 2.0 nM
Cc1ccc(C(=O)Nc2cc(CN3CCCC3)cc(C(F)(F)F)c2)cc1Nc1ncnc2cnc(N(C)C)nc12 CHEMBL3694177 IC50 2.0 nM
CCN(CC)c1ncc2ncnc(Nc3cc(C(=O)Nc4cc(CN5CCCC5)cc(C(F)(F)F)c4)ccc3C)c2n1 CHEMBL3694179 IC50 2.0 nM
Cc1ccc(C(=O)Nc2cc(CN3CCCC3)cc(C(F)(F)F)c2)cc1Nc1ncnc2cnc(NCCc3ccccc3)nc12 CHEMBL3694180 IC50 2.0 nM
Cc1ccc(C(=O)Nc2ccc(N(C)CCN(C)C)c(C(F)(F)F)c2)cc1Nc1ncnc2cnc(N3CCSCC3)nc12 CHEMBL3694183 IC50 2.0 nM
Cc1ccc(C(=O)Nc2ccc(N(C)CCN(C)C)c(C(F)(F)F)c2)cc1Nc1ncnc2cnc(N3CCC3)nc12 CHEMBL3694184 IC50 2.0 nM
Cc1ccc(C(=O)Nc2ccc(N(C)CCN(C)C)c(C(F)(F)F)c2)cc1Nc1ncnc2cnc(NCc3cccnc3)nc12 CHEMBL3694191 IC50 2.0 nM
Cc1ccc(C(=O)Nc2ccc(N(C)CCN(C)C)c(C(F)(F)F)c2)cc1Nc1ncnc2cnc(N3CCCC3)nc12 CHEMBL3694193 IC50 2.0 nM
Cc1ccc(C(=O)Nc2ccc(N(C)CCN(C)C)c(C(F)(F)F)c2)cc1Nc1ncnc2cnc(NCC(C)C)nc12 CHEMBL3694196 IC50 2.0 nM
COCCN(C)c1ncc2ncnc(Nc3cc(C(=O)Nc4cc(OCCN(C)C)cc(C(F)(F)F)c4)ccc3C)c2n1 CHEMBL3694203 IC50 2.0 nM
Cc1ccc(C(=O)Nc2cc(OCCN(C)C)cc(C(F)(F)F)c2)cc1Nc1ncnc2cnc(N3CCC3)nc12 CHEMBL3694205 IC50 2.0 nM
Cc1ccc(C(=O)Nc2cc(OCCN(C)C)cc(C(F)(F)F)c2)cc1Nc1ncnc2cnc(N3CCC(F)CC3)nc12 CHEMBL3694207 IC50 2.0 nM
Cc1ccc(C(=O)Nc2cc(OCCN(C)C)cc(C(F)(F)F)c2)cc1Nc1ncnc2cnc(N3CCCC3)nc12 CHEMBL3694212 IC50 2.0 nM
Cc1ccc(C(=O)Nc2cc(OCCN(C)C)cc(C(F)(F)F)c2)cc1Nc1ncnc2cnc(N(C)C)nc12 CHEMBL3694217 IC50 2.0 nM
Cc1ccc(C(=O)Nc2cc(N(C)CCN(C)C)cc(C(F)(F)F)c2)cc1Nc1ncnc2cnc(N3CCC(F)CC3)nc12 CHEMBL3694226 IC50 2.0 nM
Cc1ccc(C(=O)Nc2cc(N(C)CCN(C)C)cc(C(F)(F)F)c2)cc1Nc1ncnc2cnc(NCc3ccccn3)nc12 CHEMBL3697719 IC50 2.0 nM
Cc1ccc(C(=O)Nc2cc(N(C)CCN(C)C)cc(C(F)(F)F)c2)cc1Nc1ncnc2cnc(N(C)C)nc12 CHEMBL3697721 IC50 2.0 nM
Cc1ccc(C(=O)Nc2cc(N(C)CCN(C)C)cc(C(F)(F)F)c2)cc1Nc1ncnc2cnc(NCC(F)(F)F)nc12 CHEMBL3697724 IC50 2.0 nM
Cc1ccc(C(=O)Nc2ccc3c(c2)C(C)(C)C(=O)N3CCN2CCCC2)cc1Nc1ncnc2cnc(N3CCOCC3)nc12 CHEMBL3697738 IC50 2.0 nM
Cc1ccc(C(=O)Nc2cccc(C(C)(C)C#N)c2)cc1Nc1ncnc2cnc(N3CC[C@@H](F)C3)nc12 CHEMBL3697752 IC50 2.0 nM
Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1ncnc2cnc(N3CCCN(C)CC3)nc12 CHEMBL3697763 IC50 2.0 nM
COc1ccc(C(C)(C)C)cc1NC(=O)c1ccc(C)c(Nc2ncnc3cnc(N4CCCN(C)CC4)nc23)c1 CHEMBL3697771 IC50 2.0 nM
Cc1ccc(C(=O)Nc2ccc(Cl)c(C(F)(F)F)c2)cc1Nc1ncnc2cnc(N(C)CCN(C)C)nc12 CHEMBL3697781 IC50 2.0 nM
Cc1ccc(C(=O)Nc2cccc(OC(F)(F)F)c2)cc1Nc1ncnc2cnc(N(C)CCN(C)C)nc12 CHEMBL3697783 IC50 2.0 nM
Cc1ccc(C(=O)Nc2cccc(C(C)(C)C)c2)cc1Nc1ncnc2cnc(N3CCCCC3)nc12 CHEMBL3697794 IC50 2.0 nM
Cc1ccc(C(=O)Nc2cccc(C(C)(C)C)c2)cc1Nc1ncnc2cnc(N3CCCC3)nc12 CHEMBL3697818 IC50 2.0 nM
Cc1ccc(C(=O)Nc2cc(C(F)(F)F)ccn2)cc1Nc1ncnc2cnc(N3CCCC3)nc12 CHEMBL3697821 IC50 2.0 nM
COc1ccc(C(F)(F)F)cc1NC(=O)c1ccc(C)c(Nc2ncnc3cnc(N4CC[C@H](F)C4)nc23)c1 CHEMBL3697833 IC50 2.0 nM
Cc1ccc(C(=O)Nc2cccc(C(C)(C)C#N)c2)cc1Nc1ncnc2cnc(N3CCN(C)CC3)nc12 CHEMBL3697850 IC50 2.0 nM
Cc1ccc(C(=O)Nc2ccc(C#N)c(C(F)(F)F)c2)cc1Nc1ncnc2cnc(N3CCN(C)CC3)nc12 CHEMBL3697856 IC50 2.0 nM
CN1CCN(c2ncc3ncnc(Nc4cc(C(=O)Nc5cc(C(C)(C)C)on5)ccc4F)c3n2)CC1 CHEMBL3697863 IC50 2.0 nM
Cc1ccc(C(=O)Nc2cccc(S(=O)(=O)N(C)C)c2)cc1Nc1ncnc2cnc(N3CCOCC3)nc12 CHEMBL3697864 IC50 2.0 nM
Cc1ccc(C(=O)Nc2ccc(Cl)c(C(F)(F)F)c2)cc1Nc1ncnc2cnc(N3CCOCC3)nc12 CHEMBL3697881 IC50 2.0 nM
COc1ccc(C(C)(C)C)cc1NC(=O)c1ccc(C)c(Nc2ncnc3cnc(N4CCNCC4)nc23)c1 CHEMBL3697887 IC50 2.0 nM
Cc1ccc(C(=O)Nc2cc(C(C)(C)C)on2)cc1Nc1ncnc2cnc(NCC3CCOC3)nc12 CHEMBL3697902 IC50 2.0 nM
Cc1ccc(C(=O)Nc2cc(C(C)(C)C)on2)cc1Nc1ncnc2cnc(NCC3CCCCO3)nc12 CHEMBL3697904 IC50 2.0 nM
Cc1cn(-c2ncc3ncnc(Nc4cc(C(=O)Nc5cc(C(C)(C)C)on5)ccc4C)c3n2)cn1 CHEMBL3697909 IC50 2.0 nM
Cc1ccc(C(=O)Nc2cc(C(C)(C)C)on2)cc1Nc1ncnc2cnc(N3CCCOCC3)nc12 CHEMBL3697911 IC50 2.0 nM
Cn1nc(C(C)(C)C)cc1NC(=O)c1ccc(F)c(Nc2ncnc3cnc(N4CCOCC4)nc23)c1 CHEMBL3697924 IC50 2.0 nM
CN1CCN(c2cc(NC(=O)c3ccc(F)c(Nc4ncnc5cnc(N6CCOCC6)nc45)c3)cc(C(F)(F)F)c2F)CC1 CHEMBL3697925 IC50 2.0 nM
Cn1nc(C(C)(C)C)cc1NC(=O)c1ccc(F)c(Nc2ncnc3cnc(NC4CCOC4)nc23)c1 CHEMBL3697927 IC50 2.0 nM
CN(C)C1CCN(c2ncc3ncnc(Nc4cc(C(=O)Nc5cc(C(C)(C)C)on5)ccc4F)c3n2)C1 CHEMBL3641026 IC50 2.0 nM
COCCN1CCN(c2ncc3ncnc(Nc4cc(C(=O)Nc5ccc(OC)c(C(F)(F)F)c5)ccc4F)c3n2)CC1 CHEMBL3641029 IC50 2.0 nM
Cc1ccc(C(=O)Nc2cc(C(C)(C)C)n[nH]2)cc1Nc1ncnc2cnc(N3CCN(CC4CCN(C)CC4)CC3)nc12 CHEMBL3641045 IC50 2.0 nM
COCCN1CCN(c2ncc3ncnc(Nc4cc(C(=O)Nc5ccc(OC)c(C(F)(F)F)c5)ccc4C)c3n2)CC1 CHEMBL3641054 IC50 2.0 nM
Cc1ccc(C(=O)Nc2cc(C(C)(C)C)nn2C)cc1Nc1ncnc2cnc(NCc3ccccc3)nc12 CHEMBL3641056 IC50 2.0 nM
COc1ccc(NC(=O)c2ccc(C)c(Nc3ncnc4cnc(N5C[C@@H](C)N[C@@H](C)C5)nc34)c2)cc1C(F)(F)F CHEMBL3641062 IC50 2.0 nM
COc1ccc(NC(=O)c2ccc(C)c(Nc3ncnc4cnc(N5CCN(C(C)C)CC5)nc34)c2)cc1C(F)(F)F CHEMBL3641063 IC50 2.0 nM
CCN1CCN(c2cc(NC(=O)c3ccc(C)c(Nc4ncnc5cnc(N6CCOCC6)nc45)c3)cc(C(F)(F)F)c2)CC1 CHEMBL3641067 IC50 2.0 nM
COc1ccc(NC(=O)c2ccc(C)c(Nc3ncnc4cnc(N5CCCC5)nc34)c2)cc1C(F)(F)F CHEMBL3641071 IC50 2.0 nM
Cc1ccc(C(=O)Nc2cc(CN3CCCC3)cc(C(F)(F)F)c2)cc1Nc1ncnc2cnc(N3CC[C@H](F)C3)nc12 CHEMBL3641082 IC50 2.0 nM
Cc1ccc(C(=O)Nc2cc(N3CCN(C(C)C)CC3)cc(C(F)(F)F)c2)cc1Nc1ncnc2cnc(N3CCOCC3)nc12 CHEMBL3641084 IC50 2.0 nM
Cc1ccc(C(=O)Nc2cc(N3CCCN(C)CC3)cc(C(F)(F)F)c2)cc1Nc1ncnc2cnc(N3CCOCC3)nc12 CHEMBL3641086 IC50 2.0 nM
COCCN(C)c1ncc2ncnc(Nc3cc(C(=O)Nc4cc(C(C)(C)C)nn4C)ccc3C)c2n1 CHEMBL3641087 IC50 2.0 nM
COCCN(C)c1ncc2ncnc(Nc3cc(C(=O)Nc4cccc(C(F)(F)F)c4)ccc3C)c2n1 CHEMBL3641088 IC50 2.0 nM
CCN1CCN(c2cc(NC(=O)c3ccc(C)c(Nc4ncnc5cnc(N(C)CCOC)nc45)c3)cc(C(F)(F)F)c2)CC1 CHEMBL3641091 IC50 2.0 nM
COCCN(C)c1ncc2ncnc(Nc3cc(C(=O)Nc4cc(C(F)(F)F)ccn4)ccc3C)c2n1 CHEMBL3641093 IC50 2.0 nM
Cc1ccc(C(=O)Nc2cc(C(C)(C)C)on2)cc1Nc1ncnc2cnc(N3CCC(N4CCCC4)CC3)nc12 CHEMBL3641106 IC50 2.0 nM
CCN1CCN(c2ncc3ncnc(Nc4cc(C(=O)Nc5cc(C(C)(C)C)on5)ccc4C)c3n2)CC1 CHEMBL3641107 IC50 2.0 nM
Cc1ccc(C(=O)Nc2cc(C(C)(C)C)on2)cc1Nc1ncnc2cnc(N3CCN(C(C)C)CC3)nc12 CHEMBL3641108 IC50 2.0 nM
Cc1ccc(C(=O)Nc2cc(C(C)(C)C)on2)cc1Nc1ncnc2cnc(N3CCC(N(C)C)CC3)nc12 CHEMBL3641111 IC50 2.0 nM
Cc1ccc(C(=O)Nc2cc(C(C)(C)C)on2)cc1Nc1ncnc2cnc(N3C[C@@H](C)N[C@@H](C)C3)nc12 CHEMBL3641112 IC50 2.0 nM
Cc1ccc(C(=O)Nc2cc(C(C)(C)C)on2)cc1Nc1ncnc2cnc(N3C[C@H]4C[C@@H]3CN4C)nc12 CHEMBL3641113 IC50 2.0 nM
Cc1ccc(C(=O)Nc2cc(C(C)(C)C)on2)cc1Nc1ncnc2cnc(N3CCN(C)CC3)nc12 CHEMBL3641119 IC50 2.0 nM
Cc1ccc(C(=O)Nc2cc(C(C)(C)C)n[nH]2)cc1Nc1ncnc2cnc(NCc3ccccc3)nc12 CHEMBL3641127 IC50 2.0 nM
Cc1ccc(C(=O)Nc2cc(N3CCN(C)CC3)cc(C(F)(F)F)c2)cc1Nc1ncnc2cnc(N(C)CCF)nc12 CHEMBL3641133 IC50 2.0 nM
Cc1ccc(C(=O)Nc2cccc(C(C)(C)C#N)c2)cc1Nc1ncnc2cnc(NCC(C)C)nc12 CHEMBL3641135 IC50 2.0 nM
Cc1ccc(C(=O)Nc2cc(C(C)(C)C)on2)cc1Nc1ncnc2cnc(NCc3ccccc3)nc12 CHEMBL3641136 IC50 2.0 nM
Cc1ccc(C(=O)Nc2cc(CN3CCCC3)c(Cl)c(C(F)(F)F)c2)cc1Nc1ncnc2cnc(N3CCOCC3)nc12 CHEMBL3641143 IC50 2.0 nM
COCCN1CCN(c2ncc3ncnc(Nc4cc(C(=O)Nc5ccc(C#N)c(C(F)(F)F)c5)ccc4C)c3n2)CC1 CHEMBL3641147 IC50 2.0 nM
COc1c(CN2CCCC2)cc(C(F)(F)F)cc1NC(=O)c1ccc(C)c(Nc2ncnc3cnc(N4CCOCC4)nc23)c1 CHEMBL3641154 IC50 2.0 nM
COC[C@@H]1CCCN1c1ncc2ncnc(Nc3cc(C(=O)Nc4ccc(OC)c(C(F)(F)F)c4)ccc3C)c2n1 CHEMBL3641160 IC50 2.0 nM
COc1ccc(NC(=O)c2ccc(C)c(Nc3ncnc4cnc(N5CCN(CCCN6CCCC6)CC5)nc34)c2)cc1C(F)(F)F CHEMBL3641168 IC50 2.0 nM
COc1ccc(NC(=O)c2ccc(C)c(Nc3ncnc4cnc(N5CCC(N(C)C)C5)nc34)c2)cc1C(F)(F)F CHEMBL3641177 IC50 2.0 nM
COc1ncc2ncnc(Nc3cc(C(=O)Nc4cc(N5CCN(C(C)C)CC5)cc(C(F)(F)F)c4)ccc3C)c2n1 CHEMBL3641180 IC50 2.0 nM
COc1ncc2ncnc(Nc3cc(C(=O)Nc4ccc(OC)c(C(F)(F)F)c4)ccc3C)c2n1 CHEMBL3641182 IC50 2.0 nM
COc1ncc2ncnc(Nc3cc(C(=O)Nc4cc(N(C)CCN(C)C)cc(C(F)(F)F)c4)ccc3C)c2n1 CHEMBL3641184 IC50 2.0 nM
COc1ncc2ncnc(Nc3cc(C(=O)Nc4cc(C(C)(C)C)on4)ccc3C)c2n1 CHEMBL3641187 IC50 2.0 nM
Cc1ccc(C(=O)Nc2cc(C(C)(C)C)on2)cc1Nc1ncnc2cnc(N(C)C3CC(N4CCN(C)CC4)C3)nc12 CHEMBL3641200 IC50 2.0 nM
Cc1ccc(NC(=O)c2cccc(C(C)(C)C#N)c2)cc1Nc1ncnc2cnc(N(C)CCCN(C)C)nc12 CHEMBL3641224 IC50 2.0 nM
Cc1ccc(NC(=O)c2cccc(C(C)(C)C#N)c2)cc1Nc1ncnc2cnc(N3CCN(C4CC4)CC3)nc12 CHEMBL3641227 IC50 2.0 nM
Cc1ccc(NC(=O)c2cccc(C(C)(C)C#N)c2)cc1Nc1ncnc2cnc(N3CCC(F)(F)C3)nc12 CHEMBL3641233 IC50 2.0 nM
Cc1ccc(NC(=O)c2cccc(C(C)(C)C#N)c2)cc1Nc1ncnc2cnc(N3CC[C@@H](F)C3)nc12 CHEMBL3641234 IC50 2.0 nM
Cc1ccc(NC(=O)c2cccc(C(C)(C)C#N)c2)cc1Nc1ncnc2cnc(N3CC[C@H](F)C3)nc12 CHEMBL3641235 IC50 2.0 nM
Cc1ccc(NC(=O)c2cccc(C(C)(C)C#N)c2)cc1Nc1ncnc2cnc(NC3CCOCC3)nc12 CHEMBL3641238 IC50 2.0 nM
COc1ncc2ncnc(Nc3cc(NC(=O)c4cccc(C(C)(C)C#N)c4)ccc3C)c2n1 CHEMBL3641240 IC50 2.0 nM
CCN1CCN(c2cc(C(=O)Nc3ccc(C)c(Nc4ncnc5cnc(N6CCOCC6)nc45)c3)cc(C(C)(C)C#N)c2)CC1 CHEMBL3643293 IC50 2.0 nM
Cc1ccc(C(=O)Nc2cc(C(C)(C)C)on2)cc1Nc1ncnc2cncnc12 CHEMBL3643295 IC50 2.0 nM
Cc1c(Cl)cccc1S(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F CHEMBL3944643 IC50 2.0 nM
Cc1ccc(NC(=O)c2ccc(C(C)(C)C)o2)cc1-n1cc(-c2cncc(N3CCN(C)CC3)c2)nn1 CHEMBL3900628 IC50 2.0 nM
Cc1ccc(NC(=O)c2ccc(C(C)(C)C)o2)cc1-n1cc(-c2cncc(N3CCN(CC4CC4)CC3)c2)nn1 CHEMBL3928602 IC50 2.0 nM
CC(C)n1nc(C#Cc2cccc(NC(=O)c3cccc(C(F)(F)F)c3)c2)c2c(N)ncnc21 CHEMBL3736320 IC50 2.0 nM
N#Cc1c(Oc2ccc(F)c(NC(=O)Cc3cccc(C(F)(F)F)c3)c2)ccc2nc(NC(=O)C3CC3)sc12 CHEMBL3125890 IC50 2.0 nM
CCCS(=O)(=O)Nc1ccc(F)c(-n2cc(-c3cncnc3)c3nc(N(C)C4CCN(C(=O)CCOCCOCCOCCNc5cccc6c5C(=O)N(C5CCC(=O)NC5=O)C6=O)CC4)ccc32)c1F CHEMBL4443903 Kd 2.0 nM
Nc1nccc(-c2sc(C3COCCN3)nc2-c2cc(Cl)cc(NS(=O)(=O)c3cc(F)ccc3F)c2F)n1 CHEMBL5176494 IC50 2.0 nM
O=S(=O)(Nc1ccc(F)c(Nc2ccccc2-c2ncnc3[nH]cnc23)c1F)c1ccoc1 CHEMBL5269949 IC50 2.0 nM
Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1-c1nc(N2CCOCC2)cc(N2CCOCC2)n1 CHEMBL3937081 IC50 2.007 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)c(=O)n(C)c1 CHEMBL3936445 IC50 2.035 nM
Cc1ccc(NC(=O)c2ccnc(C(C)(C)C)c2)cc1-c1ccnc(N2CCOCC2)c1 CHEMBL3934972 IC50 2.054 nM
Cn1cc(-c2ccc3c(c2)CC/C3=N\O)c(-c2ccnc(N)c2)n1 CHEMBL496479 IC50 2.1 nM
CCn1cc(-c2ccnc3[nH]ccc23)c(-c2cccc(NC(=O)Nc3cccc(OC)c3)c2)n1 CHEMBL456350 IC50 2.1 nM
O=C(O)[C@H]1CCCN1C(=O)N1C2CCC1CC(c1ccnc3c(-c4cccc5[nH]ncc45)c(-c4ccncc4)nn13)C2 CHEMBL571748 IC50 2.1 nM
CC(C)(N)c1cc(C(=O)N[C@@H]2CCc3ccc(Oc4ccnc5c4CCC(=O)N5)cc3C2)cc(C(F)(F)F)c1 CHEMBL1688861 IC50 2.1 nM
CC(C)(N)c1cc(C(=O)N[C@@H]2CCc3ccc(Oc4ccnc5c4CCC(=O)N5)cc3C2)cc(C(F)(F)F)c1 CHEMBL3764895 IC50 2.1 nM
Cn1cnc(-c2cc(C(=O)N[C@@H]3CCc4ccc(Oc5ccnc6c5CCC(=O)N6)cc4C3)cc(C(F)(F)F)c2)c1 CHEMBL3763694 IC50 2.1 nM
Cn1cc(-c2cc(C(=O)N[C@@H]3CCc4ccc(Oc5ccnc6c5CCC(=O)N6)cc4C3)cc(C(F)(F)F)c2)cn1 CHEMBL3763646 IC50 2.1 nM
Cc1ccc(NC(=O)Nc2ccc(Cl)c(C(F)(F)F)c2)cc1NC(=O)C1(c2ncnc3[nH]ccc23)CC1 CHEMBL4559599 IC50 2.1 nM
Nc1nccc(-c2sc(C3CCN3)nc2-c2cccc(NS(=O)(=O)c3cc(F)ccc3F)c2F)n1 CHEMBL5203353 IC50 2.1 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOC(C)(C)C2)nc(N2CCOCC2)n1 CHEMBL3966257 IC50 2.118 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1nc(N2CCOCC2)cc(N2CCOCC2)n1 CHEMBL3970191 IC50 2.168 nM
Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1ncccc1-c1ncnc2[nH]cnc12 CHEMBL3354381 IC50 2.17 nM
Cc1ccc(NC(=O)c2csc(C(F)(F)F)n2)cc1-c1cc(N2CCOCC2)nc(N2CCOCC2)n1 CHEMBL3958636 IC50 2.177 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)c(=O)n([C@@H](C)C#N)c1 CHEMBL3935549 IC50 2.181 nM
Cc1ncc(NC(=O)c2cccc(C(C)(F)F)c2)cc1-c1ccnc(N2CCOCC2)c1 CHEMBL3951813 IC50 2.183 nM
O=C(Nc1cccc(C(F)(F)F)c1)c1ccc(CF)c(-c2ccnc(N3CCOCC3)c2)c1 CHEMBL3919411 IC50 2.185 nM
COc1cc(-c2cc(NC(=O)c3cccc(C(F)(F)F)c3)ccc2C)nc(N2CCOCC2)c1 CHEMBL3926287 IC50 2.191 nM
CNCc1cc(C(=O)N[C@@H]2CCc3ccc(Oc4ccnc5c4CCC(=O)N5)cc3C2)cc(C(F)(F)F)c1 CHEMBL1688876 IC50 2.2 nM
CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]cc(I)c3c2)c1F CHEMBL1822247 IC50 2.2 nM
CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]nc(OC)c3c2)c1Cl CHEMBL1939068 IC50 2.2 nM
CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]c(-c4ccc(Br)cc4)nc3c2)c1F CHEMBL2436804 IC50 2.2 nM
CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]c(-c4ccc(Cl)cc4)nc3c2)c1F CHEMBL2436808 IC50 2.2 nM
CNCc1cc(C(=O)N[C@@H]2CCc3ccc(Oc4ccnc5c4CCC(=O)N5)cc3C2)cc(C(F)(F)F)c1 CHEMBL3764238 IC50 2.2 nM
O=C1CCc2c(Oc3ccc4c(c3)C[C@H](NC(=O)c3cc(C(F)(F)F)cc(C5(O)CNC5)c3)CC4)ccnc2N1 CHEMBL3764870 IC50 2.2 nM
Cc1ccc(NC(=O)c2ccnc(S(C)(=O)=O)c2)cc1-c1cc(N2CCOCC2)c(=O)n(C)c1 CHEMBL3959933 IC50 2.202 nM
Cc1ccc(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1-c1cc(N2CCOCC2)nc(N2CCOCC2)n1 CHEMBL3938806 IC50 2.224 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)c(=O)n(CCO)c1 CHEMBL3931694 IC50 2.23 nM
Cc1ccc(NC(=O)c2cccc(C(F)F)c2)cc1-c1cc(N2CCOCC2)c(=O)n(C)n1 CHEMBL3951205 IC50 2.242 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(C(F)(F)F)nc(N2CCOCC2)n1 CHEMBL3896594 IC50 2.273 nM
c1cc(-c2c(-c3ccncc3)nn3c(-c4ccc(CN5C[C@@H]6C[C@H]5CN6)cc4)ccnc23)c2cn[nH]c2c1 CHEMBL1276191 IC50 2.3 nM
CCOC(=O)c1oc2cnccc2c1Nc1ccc(Cl)c(O)c1 CHEMBL1667912 IC50 2.3 nM
CCCS(=O)(=O)Nc1cc(F)c(F)c(C(=O)Nc2cnc3[nH]nc(OC)c3c2)c1F CHEMBL1822074 IC50 2.3 nM
COc1n[nH]c2ncc(NC(=O)c3c(F)ccc(NC(=O)c4cccc(C(C)(C)C#N)c4)c3F)cc12 CHEMBL2153510 IC50 2.3 nM
COC(=O)N[C@@H](C)CNc1nccc(-c2cn(C(C)C)nc2-c2cccc(NS(C)(=O)=O)c2F)n1 CHEMBL3905481 IC50 2.3 nM
Cc1ccc(NC(=O)c2ccc(Cl)c(C(F)(F)F)c2)cc1NC(=O)C1(c2ncnc3[nH]ccc23)CC1 CHEMBL4518581 IC50 2.3 nM
Nc1ncnc2c(C(=O)Nc3c(Cl)ccc(NS(=O)(=O)N4CCCC4)c3F)cccc12 CHEMBL4780489 Ki 2.3 nM
Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)nc(N2CCOCC2)c1 CHEMBL3913923 IC50 2.384 nM
Oc1cc(-c2nc(-c3ccccc3)[nH]c2-c2ccncc2)ccc1Cl CHEMBL373011 Kd 2.4 nM
NCCn1cc(-c2ccc3c(c2)CC/C3=N\O)c(-c2ccncc2)n1 CHEMBL496276 IC50 2.4 nM
O/N=C1\CCc2cc(-c3cc(C4CCNCC4)oc3-c3ccncc3)ccc21 CHEMBL477149 Kd 2.4 nM
CN(C)CCOc1ccc(-c2cc(-c3ccncc3)c(-c3ccc4c(c3)CC/C4=N\O)[nH]2)cc1 CHEMBL1964267 Kd 2.4 nM
Cc1ccc(Nc2c(-c3ncccn3)oc3cnccc23)c2cn[nH]c12 CHEMBL1667920 IC50 2.4 nM
CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]nc(OCC)c3c2)c1F CHEMBL1822251 IC50 2.4 nM
CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]c(-c4ccc(Cl)cc4)cc3c2)c1F CHEMBL2436809 IC50 2.4 nM
Oc1c(F)ccc(Nc2ncnc3ccc(-c4ccc5[nH]ncc5c4)cc23)c1F CHEMBL3665864 IC50 2.4 nM
Cc1cc2[nH]c(C3C4Oc5ccc(Oc6ccnc7c6CCC(=O)N7)cc5C43)nc2cc1F CHEMBL3970248 IC50 2.4 nM
Nc1nccc(C2=C(c3cc(Cl)cc(NS(=O)(=O)c4c(F)cccc4F)c3Cl)C(=O)C3(CCCC3)O2)n1 CHEMBL3919165 IC50 2.4 nM
Cc1ccc(NC(=O)c2cccc(S(C)(=O)=O)c2)cc1-c1cc(N2CCOCC2)nc(N2CCOCC2)n1 CHEMBL3946466 IC50 2.416 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CC3(COC3)C2)nc(N2CCOCC2)n1 CHEMBL3894928 IC50 2.454 nM
Cc1ccc(NC(=O)c2ccnc(C(C)(C)C)c2)cc1-c1cc(N2CCOCC2)c(=O)n(C)c1 CHEMBL3911091 IC50 2.454 nM
Cc1ccc(NC(=O)c2cc(C(F)(F)F)cc(S(C)(=O)=O)c2)cc1-c1cc(N2CCOCC2)c(=O)n(C)c1 CHEMBL3975494 IC50 2.474 nM
CCOc1ncc(-c2cc(NC(=O)c3cccc(C(F)(F)F)c3)ccc2C)cc1N1CCOCC1 CHEMBL3910380 IC50 2.484 nM
COc1ccc(S(=O)(=O)NCCCNc2nccc(-c3[nH]c(-c4ccccc4)nc3-c3ccc(F)c(O)c3)n2)cc1 CHEMBL4793723 IC50 2.49 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCO[C@H](C)C2)nc(N2CCOCC2)n1 CHEMBL4112482 IC50 2.499 nM
CCn1cc(-c2ccnc3[nH]ccc23)c(-c2cccc(NC(=O)Nc3ccc(C(F)(F)F)cc3)c2)n1 CHEMBL523411 IC50 2.5 nM
CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]c(-c4ccc(OC(F)(F)F)cc4)nc3c2)c1F CHEMBL2436792 IC50 2.5 nM
Cc1ccc(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1-c1cc(N2CCOCC2)c(=O)n(C)c1 CHEMBL3981117 IC50 2.5 nM
O=C1CCc2c(Oc3ccc4c(c3)C3C(O4)C3c3nc4ccc(O)cc4[nH]3)ccnc2N1 CHEMBL3954132 IC50 2.5 nM
CC1(C)OC(c2ccnc(N)n2)=C(c2cc(Cl)cc(NS(=O)(=O)c3ccccc3F)c2F)C1=O CHEMBL3945780 IC50 2.5 nM
CC1(C)OC(c2ccnc(NCCC#N)n2)=C(c2cc(Cl)cc(NS(=O)(=O)c3c(F)cccc3F)c2F)C1=O CHEMBL3950482 IC50 2.5 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1Nc1ncccc1-c1ncnc2[nH]cnc12 CHEMBL3354835 IC50 2.51 nM
Cc1ccc(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1-c1ccnc(N2CCO[C@H](CO)C2)c1 CHEMBL3971254 IC50 2.533 nM
Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1-c1ccnc(N2CCOCC2)c1 CHEMBL3982101 IC50 2.553 nM
Cc1cc(C(=O)Nc2ccc(C)c(Nc3ncccc3-c3ncnc4[nH]cnc34)c2)ccc1Cl CHEMBL3354837 IC50 2.56 nM
CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(Cl)cc23)c1F CHEMBL1230020 Ki 2.6 nM
Nc1nccc(C2=C(c3cc(Cl)cc(NS(=O)(=O)c4cc(F)ccc4F)c3F)C(=O)C3(CCCC3)O2)n1 CHEMBL3951559 IC50 2.6 nM
CCCS(=O)(=O)Nc1ccc(F)c(-n2cc(-c3cncnc3)c3nc(N(C)C4CCN(C(=O)CCOCCOCCOCCNc5cccc6c5C(=O)N(C5CCC(=O)N(C)C5=O)C6=O)CC4)ccc32)c1F CHEMBL4440761 Kd 2.6 nM
CCOc1ncc(-c2cc(NC(=O)c3ccnc(C(F)(F)F)c3)ccc2C)cc1N1CCOCC1 CHEMBL3917649 IC50 2.618 nM
COc1cccc(-c2nc3sccn3c2-c2ccnc(NCCN3CCCN(C)S3(=O)=O)n2)c1 CHEMBL5073246 IC50 2.62 nM
CCOc1ncc(-c2cc(NC(=O)c3ccnc(C(C)(C)C#N)c3)ccc2C)cc1N1CCOCC1 CHEMBL3890682 IC50 2.648 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)cnn1 CHEMBL3897780 IC50 2.655 nM
COc1ccc(C(=O)Nc2cnc(C)c(-c3cc(N4CCOCC4)c(=O)n(C)c3)c2)cc1C(F)(F)F CHEMBL3937040 IC50 2.664 nM
COCCN1CCC(c2cc(-c3ccc4c(c3)CC/C4=N\O)c(-c3ccncc3)o2)CC1 CHEMBL515796 Kd 2.7 nM
CC(C)NC(=O)c1oc2cnccc2c1Nc1ccc(Cl)c2[nH]ncc12 CHEMBL1667919 IC50 2.7 nM
CN(C)Cc1cc(C(=O)N[C@@H]2CCc3ccc(Oc4ccnc5c4CCC(=O)N5)cc3C2)cc(C(F)(F)F)c1 CHEMBL1688860 IC50 2.7 nM
CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]nc(C4CC4)c3c2)c1F CHEMBL1939070 IC50 2.7 nM
CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]c(-c4ccc(C#N)cc4)nc3c2)c1F CHEMBL2436793 IC50 2.7 nM
CN(C)Cc1cc(C(=O)N[C@@H]2CCc3ccc(Oc4ccnc5c4CCC(=O)N5)cc3C2)cc(C(F)(F)F)c1 CHEMBL3764357 IC50 2.7 nM
CCCS(=O)(=O)Nc1c(F)ccc(-c2nn(C(C)C)cc2-c2ccnc(NC[C@H](C)NC(=O)OC)n2)c1F CHEMBL3901648 IC50 2.7 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cnc(OC2CCOCC2)c(N2CCOCC2)c1 CHEMBL3893855 IC50 2.708 nM
Cc1ccc(NC(=O)c2ccc(Cl)c(C(F)(F)F)c2)cc1Nc1ncccc1-c1ncnc2[nH]cnc12 CHEMBL3354394 IC50 2.71 nM
O=C(Nc1cccc(C(F)(F)F)c1)c1ccc(Cl)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1 CHEMBL3354389 IC50 2.78 nM
CCNc1nccc(C2=C(c3cc(Cl)cc(NS(=O)(=O)c4cc(F)ccc4F)c3F)C(=O)C(C)(C)O2)n1 CHEMBL3927350 IC50 2.8 nM
CNc1cc(C2(C(=O)Nc3cc(C(=O)Nc4ccc(Cl)c(C(F)(F)F)c4)ccc3C)CC2)ncn1 CHEMBL4060057 IC50 2.8 nM
CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(-c4ccc(N)cc4)cc23)c1F CHEMBL5440394 Kd 2.8 nM
CCN1CCN(c2cc(C(=O)Nc3ccc(C)c(-c4ccnc(N5CCOCC5)c4)c3)cc(C(F)(F)F)c2)CC1 CHEMBL3946717 IC50 2.834 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1nc(C(C)C)cc(N2CCOCC2)n1 CHEMBL3943351 IC50 2.875 nM
Cn1cc(-c2ccc3c(c2)CC/C3=N\O)c(-c2ccnc(O)c2)n1 CHEMBL497700 IC50 2.9 nM
CC(C)(N)c1cc(NC(=O)[C@H]2CCc3ccc(Oc4ccnc5c4CCC(=O)N5)cc3C2)cc(C(F)(F)F)c1 CHEMBL1614728 IC50 2.9 nM
CN(C)Cc1cc(C(=O)N[C@@H]2CCc3ccc(Oc4ccnc(NC(=O)C5CC5)c4)cc3C2)cc(C(F)(F)F)c1 CHEMBL1688874 IC50 2.9 nM
COc1cc(-c2ccc3ncnc(Nc4ccc(F)c(O)c4F)c3c2)ccc1O CHEMBL3665863 IC50 2.9 nM
NCc1cc(C(=O)N[C@@H]2CCc3ccc(Oc4ccnc5c4CCC(=O)N5)cc3C2)cc(C(F)(F)F)c1 CHEMBL3764101 IC50 2.9 nM
O=C1CCc2c(Oc3ccc4c(c3)C[C@H](NC(=O)c3cc(-c5cn[nH]c5)cc(C(F)(F)F)c3)CC4)ccnc2N1 CHEMBL3765708 IC50 2.9 nM
COC(=O)NC[C@H](C)Nc1nccc(-c2cn(C(C)C)nc2-c2cc(Cl)cc(NS(C)(=O)=O)c2F)n1 CHEMBL3962696 IC50 2.9 nM
Cc1ccc(NC(=O)c2cccc(C(C)(C)C#N)c2)cc1-c1cc(N2CCOCC2)c(=O)n(C)c1 CHEMBL3916539 IC50 2.908 nM
CNC[C@@H]1CN(c2cc(-c3cc(NC(=O)c4ccnc(C(C)(C)C#N)c4)ccc3C)ccn2)CCO1 CHEMBL4111455 IC50 2.927 nM
COc1cc(-c2nn(-c3ccc(NC(=O)CN4CCOCC4)cc3)cc2-c2ccncc2)ccc1Cl CHEMBL5290203 IC50 2.98 nM
Cc1ncc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2=O)nc(N2CCOCC2)n1 CHEMBL3977439 IC50 2.996 nM
NC(=O)c1cccc(Nc2nccc(-c3[nH]c(C4CC4)nc3-c3cccc(NC(=O)Cc4ccc(Cl)cc4)c3)n2)c1 CHEMBL254966 IC50 3.0 nM
CNc1nccc(-c2[nH]c(C3CC3)nc2-c2cccc(NC(=O)Cc3ccc(Cl)cc3)c2)n1 CHEMBL403854 IC50 3.0 nM
CCN1C2CCC1CC(c1ccnc3c(-c4ccc(F)c(O)c4)c(-c4ccncc4)nn13)C2 CHEMBL568855 IC50 3.0 nM
Cc1nc2c(Oc3ccc(NC(=O)Nc4cc(C(F)(F)F)ccc4F)c(F)c3)ccnc2[nH]c1=O CHEMBL1214614 IC50 3.0 nM
CSc1cc(Oc2ccnc3[nH]c(=O)c(=O)[nH]c23)ccc1NC(=O)Nc1ccc(Cl)c(C(F)(F)F)c1 CHEMBL1213998 IC50 3.0 nM
CSc1cc(Oc2ccnc3[nH]c(=O)c(C)nc23)ccc1NC(=O)Nc1cc(C(C)(C)C)nn1-c1ccccc1 CHEMBL1214055 IC50 3.0 nM
CCOC(=O)c1oc2cnccc2c1Nc1ccc2c(O)c(F)ccc2c1 CHEMBL1667907 IC50 3.0 nM
CCOC(=O)c1sc2cnccc2c1Nc1ccc2c(c1)CC/C2=N/O CHEMBL1668909 IC50 3.0 nM
O/N=C1/CCc2cc(Nc3c(-c4ccccc4)sc4cnccc34)ccc21 CHEMBL1668913 IC50 3.0 nM
O/N=C1/CCc2cc(Nc3c(-c4cccnc4)sc4cnccc34)ccc21 CHEMBL1668914 IC50 3.0 nM
Cc1ccc(-c2oc3cnccc3c2Nc2ccc3c(c2)CC/C3=N\O)cc1 CHEMBL1668918 IC50 3.0 nM
c1cc(-c2nn(C3CCNCC3)cc2-c2ccc3c(c2)Cc2c[nH]nc2-3)ccn1 CHEMBL1780165 IC50 3.0 nM
Cn1cc(-c2ccc(C(=O)N3N=C(c4cccnc4)CC3c3c(O)cccc3F)s2)cn1 CHEMBL1779424 IC50 3.0 nM
NCc1ccc(-c2ccc(C(=O)N3N=C(c4cccnc4)CC3c3c(O)cccc3F)s2)cc1 CHEMBL1778667 IC50 3.0 nM
O=C(c1ccc(-c2ccc3c(c2)CNCC3)s1)N1N=C(c2cccnc2)CC1c1c(O)cccc1F CHEMBL1778668 IC50 3.0 nM
O=C(c1ccc(-c2ccc3c(c2)CCNC3)s1)N1N=C(c2cccnc2)CC1c1c(O)cccc1F CHEMBL1778669 IC50 3.0 nM
CC(=O)Nc1cncc(C2=NN(C(=O)c3ccc(-c4ccccn4)s3)C(c3ccccc3O)C2)c1 CHEMBL1778673 IC50 3.0 nM
O=C(c1ccc(-c2ccccn2)s1)N1N=C(c2cncc(CO)c2)CC1c1ccccc1O CHEMBL1778674 IC50 3.0 nM
Nc1cncc(C2=NN(C(=O)c3ccc(-c4ccccn4)s3)C(c3ccccc3O)C2)c1 CHEMBL1778675 IC50 3.0 nM
O=C(c1ccc(-c2ccc3c(c2)CNC3)s1)N1N=C(c2cncc(CO)c2)CC1c1c(O)cccc1F CHEMBL1779280 IC50 3.0 nM
Nc1cncc(C2=NN(C(=O)c3ccc(-c4ccccn4)s3)C(c3c(O)cccc3F)C2)c1 CHEMBL1779282 IC50 3.0 nM
CC(C)(CO)Nc1nc(-c2cc(O)cc(Cl)c2)c2c(N)c(C(N)=O)sc2n1 CHEMBL1934647 IC50 3.0 nM
NC(=O)c1sc2nc(NC3CC3)nc(-c3cccc(NC(=O)Nc4ccc(C(F)(F)F)cc4)c3)c2c1N CHEMBL1934646 IC50 3.0 nM
Cn1c(Nc2ccc(C(F)(F)F)cc2)nc2ccc(Oc3ccnc(-c4cnc(C(F)(F)F)[nH]4)c3)cc21 CHEMBL1946171 IC50 3.0 nM
CCCS(=O)(=O)Nc1ccc(F)c(-c2cc3cnc(NCC4CC4)nc3n(C)c2=O)c1F CHEMBL2023342 IC50 3.0 nM
CC(C)(C#N)c1cccc(C(=O)Nc2ccc(F)c(C(=O)Nc3cnc4[nH]nc(C5CC5)c4c3)c2F)c1 CHEMBL2153512 IC50 3.0 nM
N#CCNc1ncnc(-n2c(Nc3cccc(O)c3)nc3ccccc32)n1 CHEMBL1615182 IC50 3.0 nM
CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]c(-c4cccnc4)nc3c2)c1F CHEMBL2436798 IC50 3.0 nM
CCCS(=O)(=O)Nc1ccc(Cl)c(N(C)c2ccc3ncn(C)c(=O)c3c2)c1F CHEMBL3233047 IC50 3.0 nM
CC(=O)Nc1cc(Oc2ccc3c(c2)nc(Nc2cccc(C(F)(F)F)c2)n3C)ccn1 CHEMBL3335375 IC50 3.0 nM
CC(=O)Nc1cc(Oc2ccc3c(c2)nc(Nc2cccc(C(C)(C)C)c2)n3C)ccn1 CHEMBL3335371 IC50 3.0 nM
CNc1cc2nc(C)c(-c3ccc(F)c(NC(=O)NCCC(C)(C)C)c3)cc2cn1 CHEMBL3577120 IC50 3.0 nM
O=S(=O)(Nc1ccc(F)c(C#Cc2cnc3[nH]nc(-c4ccncc4)c3c2)c1F)c1cccnc1 CHEMBL3582396 IC50 3.0 nM
O=S(=O)(Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F)c1ccccc1F CHEMBL3800226 IC50 3.0 nM
O=S(=O)(Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F)c1cccc(F)c1 CHEMBL3799014 IC50 3.0 nM
O=S(=O)(CC(F)(F)F)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F CHEMBL3800014 IC50 3.0 nM
CC(C)(C)c1nc(-c2ccnc(N)n2)c(-c2cc(Cl)cc(NS(C)(=O)=O)c2F)[nH]1 CHEMBL3651660 IC50 3.0 nM
Cc1ccc(C(=O)Nc2ccc(C(F)(F)F)cc2)cc1Nc1ncnc2c(N)nc(N3CCN(C4CCN(C)CC4)CC3)nc12 CHEMBL3689906 IC50 3.0 nM
Cc1ccc(C(=O)Nc2cc(C(C)(C)C)on2)cc1Nc1ncnc2c(N)nc(N3CCN(C)CC3)nc12 CHEMBL3689908 IC50 3.0 nM
Cc1ccc(C(=O)Nc2cc(C(C)(C)C)n[nH]2)cc1Nc1ncnc2c(N)nc(N3CCCN(C)CC3)nc12 CHEMBL3689913 IC50 3.0 nM
Cc1ccc(C(=O)Nc2cc(C(C)(C)C)n[nH]2)cc1Nc1ncnc2c(N)nc(N3CCN(C)CC3)nc12 CHEMBL3689917 IC50 3.0 nM
CN1CCC(N2CCN(c3nc(N)c4ncnc(Nc5cc(C(=O)Nc6cccc(C(F)(F)F)c6)ccc5Cl)c4n3)CC2)CC1 CHEMBL3689924 IC50 3.0 nM
Cc1ccc(C(=O)Nc2cc(C(C)(C)C)n[nH]2)cc1Nc1ncnc2c(N)nc(N3CCN(CC4CCCN(C)C4)CC3)nc12 CHEMBL3689939 IC50 3.0 nM
Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1ncnc2c(N)nc(N3CCCN(c4ccccn4)CC3)nc12 CHEMBL3694024 IC50 3.0 nM
Cc1ccc(C(=O)Nc2cc(N(C)CCN(C)C)cc(C(F)(F)F)c2)cc1Nc1ncnc2c(N)nc(N3CCCOCC3)nc12 CHEMBL3694027 IC50 3.0 nM
Cc1ccc(C(=O)Nc2ccc(Cl)c(C(F)(F)F)c2)cc1Nc1ncnc2c(N)nc(N3CCN(C)CC3)nc12 CHEMBL3694031 IC50 3.0 nM
CCN1CCN(c2cc(NC(=O)c3ccc(C)c(Nc4ncnc5c(N)nc(N6CCCOCC6)nc45)c3)cc(C(F)(F)F)c2)CC1 CHEMBL3694038 IC50 3.0 nM
COc1ccc(NC(=O)c2ccc(Cl)c(Nc3ncnc4cnc(N(C)CCN5CCCC5)nc34)c2)cc1C(F)(F)F CHEMBL3694071 IC50 3.0 nM
COc1ccc(NC(=O)c2ccc(Cl)c(Nc3ncnc4cnc(NCCN(C)C)nc34)c2)cc1C(F)(F)F CHEMBL3694077 IC50 3.0 nM
COCCN(C)c1ncc2ncnc(Nc3cc(C(=O)Nc4ccc(OC)c(C(F)(F)F)c4)ccc3OC)c2n1 CHEMBL3694080 IC50 3.0 nM
COc1ccc(C(=O)Nc2ccc(OC)c(C(F)(F)F)c2)cc1Nc1ncnc2cnc(N3CCCN(C)CC3)nc12 CHEMBL3694083 IC50 3.0 nM
COc1ccc(C(=O)Nc2ccc(OC)c(C(F)(F)F)c2)cc1Nc1ncnc2cnc(N(C)CCN3CCCC3)nc12 CHEMBL3694084 IC50 3.0 nM
COc1ccc(C(=O)Nc2ccc(OC)c(C(F)(F)F)c2)cc1Nc1ncnc2cnc(NCCN3CCOCC3)nc12 CHEMBL3694091 IC50 3.0 nM
COc1ccc(NC(=O)c2ccc(F)c(Nc3ncnc4cnc(NCCCN5CCOCC5)nc34)c2)cc1C(F)(F)F CHEMBL3694099 IC50 3.0 nM
CN(CCN1CCCC1)c1ncc2ncnc(Nc3cc(C(=O)Nc4cc(C(C)(C)C)on4)ccc3Cl)c2n1 CHEMBL3694134 IC50 3.0 nM
COc1ccc(C(=O)Nc2cc(C(C)(C)C)on2)cc1Nc1ncnc2cnc(N3CCCCCC3)nc12 CHEMBL3694150 IC50 3.0 nM
Cc1ccc(C(=O)Nc2cc(CN3CCCC3)cc(C(F)(F)F)c2)cc1Nc1ncnc2cnc(NCc3ccccc3)nc12 CHEMBL3694167 IC50 3.0 nM
COCCN(C)c1ncc2ncnc(Nc3cc(C(=O)Nc4ccc(N(C)CCN(C)C)c(C(F)(F)F)c4)ccc3C)c2n1 CHEMBL3694181 IC50 3.0 nM
Cc1ccc(C(=O)Nc2ccc(N(C)CCN(C)C)c(C(F)(F)F)c2)cc1Nc1ncnc2cnc(N3CCCCCC3)nc12 CHEMBL3694182 IC50 3.0 nM
Cc1ccc(C(=O)Nc2ccc(N(C)CCN(C)C)c(C(F)(F)F)c2)cc1Nc1ncnc2cnc(N3CCC(F)(F)CC3)nc12 CHEMBL3694186 IC50 3.0 nM
Cc1ccc(C(=O)Nc2ccc(N(C)CCN(C)C)c(C(F)(F)F)c2)cc1Nc1ncnc2cnc(NCc3ccccc3)nc12 CHEMBL3694189 IC50 3.0 nM
Cc1ccc(C(=O)Nc2ccc(N(C)CCN(C)C)c(C(F)(F)F)c2)cc1Nc1ncnc2cnc(N3CCCCC3)nc12 CHEMBL3694190 IC50 3.0 nM
Cc1ccc(C(=O)Nc2ccc(N(C)CCN(C)C)c(C(F)(F)F)c2)cc1Nc1ncnc2cnc(N3CCOCC3)nc12 CHEMBL3694192 IC50 3.0 nM
Cc1ccc(C(=O)Nc2ccc(N(C)CCN(C)C)c(C(F)(F)F)c2)cc1Nc1ncnc2cnc(NCc3ccncc3)nc12 CHEMBL3694198 IC50 3.0 nM
Cc1ccc(C(=O)Nc2ccc(N(C)CCN(C)C)c(C(F)(F)F)c2)cc1Nc1ncnc2cnc(N(C)C)nc12 CHEMBL3694199 IC50 3.0 nM
CCN(CC)c1ncc2ncnc(Nc3cc(C(=O)Nc4ccc(N(C)CCN(C)C)c(C(F)(F)F)c4)ccc3C)c2n1 CHEMBL3694201 IC50 3.0 nM
Cc1ccc(C(=O)Nc2cc(OCCN(C)C)cc(C(F)(F)F)c2)cc1Nc1ncnc2cnc(N3CCSCC3)nc12 CHEMBL3694204 IC50 3.0 nM
CCN(CC)c1ncc2ncnc(Nc3cc(C(=O)Nc4cc(OCCN(C)C)cc(C(F)(F)F)c4)ccc3C)c2n1 CHEMBL3694219 IC50 3.0 nM
Cc1ccc(C(=O)Nc2cc(N(C)CCN(C)C)cc(C(F)(F)F)c2)cc1Nc1ncnc2cnc(N3CCC3)nc12 CHEMBL3694222 IC50 3.0 nM
Cc1ccc(C(=O)Nc2cc(N(C)CCN(C)C)cc(C(F)(F)F)c2)cc1Nc1ncnc2cnc(NCC(C)C)nc12 CHEMBL3697718 IC50 3.0 nM
Cc1ccc(C(=O)Nc2cccc(C(C)(C)C#N)c2)cc1Nc1ncnc2cnc(N3CCCN(C)CC3)nc12 CHEMBL3697726 IC50 3.0 nM
Cc1ccc(C(=O)Nc2cccc(C(C)(C)C#N)c2)cc1Nc1ncnc2cnc(N3CCCCC3)nc12 CHEMBL3697759 IC50 3.0 nM
Cc1ccc(C(=O)Nc2ccc(F)c(C(F)(F)F)c2)cc1Nc1ncnc2cnc(N3CCCN(C)CC3)nc12 CHEMBL3697762 IC50 3.0 nM
Cc1ccc(C(=O)Nc2cccc(S(=O)(=O)N(C)C)c2)cc1Nc1ncnc2cnc(N3CCCC3)nc12 CHEMBL3697820 IC50 3.0 nM
Cc1ccc(C(=O)Nc2cc(C(F)(F)F)ccn2)cc1Nc1ncnc2cnc(N3CCCN(C)CC3)nc12 CHEMBL3697828 IC50 3.0 nM
Cc1ccc(C(=O)Nc2ccc(C#N)c(C(F)(F)F)c2)cc1Nc1ncnc2cnc(N3CCCN(C)CC3)nc12 CHEMBL3697829 IC50 3.0 nM
Cc1ccc(C(=O)Nc2ccc(F)c(C(F)(F)F)c2)cc1Nc1ncnc2cnc(N3CC[C@H](F)C3)nc12 CHEMBL3697831 IC50 3.0 nM
CN(C)CCN(C)c1ncc2ncnc(Nc3cc(C(=O)Nc4cc(C(C)(C)C)on4)ccc3F)c2n1 CHEMBL3697861 IC50 3.0 nM
Cc1ccc(C(=O)Nc2cc(C(C)(C)C)on2)cc1Nc1ncnc2cnc(N(C)CC3CCOC3)nc12 CHEMBL3697903 IC50 3.0 nM
COC[C@@H]1CCCN1c1ncc2ncnc(Nc3cc(C(=O)Nc4cc(C(C)(C)C)on4)ccc3C)c2n1 CHEMBL3697905 IC50 3.0 nM
CC(C)(C)c1cc(NC(=O)c2ccc(F)c(Nc3ncnc4cnc(NC5CCOC5)nc34)c2)no1 CHEMBL3639967 IC50 3.0 nM
CC(C)(C)c1cc(NC(=O)c2ccc(F)c(Nc3ncnc4cnc(NC5CCOC5)nc34)c2)[nH]n1 CHEMBL3697932 IC50 3.0 nM
CC(C)N1CCN(c2ncc3ncnc(Nc4cc(C(=O)Nc5cc(C(C)(C)C)on5)ccc4F)c3n2)CC1 CHEMBL3697936 IC50 3.0 nM
CN(C)C1CCN(c2ncc3ncnc(Nc4cc(C(=O)Nc5cc(C(C)(C)C)on5)ccc4F)c3n2)CC1 CHEMBL3641028 IC50 3.0 nM
COc1ccc(NC(=O)c2ccc(F)c(Nc3ncnc4cnc(N5CCN(C(C)C)CC5)nc34)c2)cc1C(F)(F)F CHEMBL3641030 IC50 3.0 nM
COc1ccc(NC(=O)c2ccc(F)c(Nc3ncnc4cnc(N5CCC(N(C)C)CC5)nc34)c2)cc1C(F)(F)F CHEMBL3641033 IC50 3.0 nM
COc1ccc(NC(=O)c2ccc(C)c(Nc3ncnc4cnc(N5CC[C@H](F)C5)nc34)c2)cc1C(F)(F)F CHEMBL3641038 IC50 3.0 nM
COc1ccc(C(C)(C)C)cc1NC(=O)c1ccc(C)c(Nc2ncnc3cnc(N4CCN(CC5CCN(C)CC5)CC4)nc23)c1 CHEMBL3641042 IC50 3.0 nM
COc1ccc(NC(=O)c2ccc(C)c(Nc3ncnc4cnc(N5C[C@H]6C[C@@H]5CN6C)nc34)c2)cc1C(F)(F)F CHEMBL3641058 IC50 3.0 nM
Cc1ccc(C(=O)Nc2cc(C(F)(F)F)ccn2)cc1Nc1ncnc2cnc(N3CCN(CC(C)C)CC3)nc12 CHEMBL3641075 IC50 3.0 nM
Cc1cn(-c2cc(NC(=O)c3ccc(C)c(Nc4ncnc5cnc(N6CCC(F)(F)C6)nc45)c3)cc(C(F)(F)F)c2)cn1 CHEMBL3641076 IC50 3.0 nM
Cc1ccc(C(=O)Nc2cc(N3CCN(C(C)C)CC3)cc(C(F)(F)F)c2)cc1Nc1ncnc2cnc(N3CC[C@H](F)C3)nc12 CHEMBL3641079 IC50 3.0 nM
Cc1ccc(C(=O)Nc2cc(C(C)(C)C)on2)cc1Nc1ncnc2cnc(N3CCN4CCCC4C3)nc12 CHEMBL3641100 IC50 3.0 nM
Cc1ccc(C(=O)Nc2cc(C(C)(C)C)on2)cc1Nc1ncnc2cnc(N3CCC(N4CCCCC4)CC3)nc12 CHEMBL3641101 IC50 3.0 nM
Cc1ccc(C(=O)Nc2cc(C(C)(C)C)nn2C)cc1Nc1ncnc2cnc(NCC(C)C)nc12 CHEMBL3641114 IC50 3.0 nM
Cc1ccc(C(=O)Nc2cc(C(C)(C)C)n[nH]2)cc1Nc1ncnc2cnc(N3CC[C@H](F)C3)nc12 CHEMBL3641123 IC50 3.0 nM
COCCN1CCN(c2ncc3ncnc(Nc4cc(C(=O)Nc5cc(C(C)(C)C)on5)ccc4C)c3n2)CC1 CHEMBL3641132 IC50 3.0 nM
Cc1ccc(C(=O)Nc2cc(C(F)(F)F)ccn2)cc1Nc1ncnc2cnc(NCc3ccccc3)nc12 CHEMBL3641137 IC50 3.0 nM
Cc1ccc(C(=O)Nc2cc(N3C[C@@H](C)N[C@@H](C)C3)cc(C(F)(F)F)c2)cc1Nc1ncnc2cnc(N3CCOCC3)nc12 CHEMBL3641139 IC50 3.0 nM
Cc1ccc(C(=O)Nc2cc(N3CCOCC3)cc(C(F)(F)F)c2)cc1Nc1ncnc2cnc(N3CCOCC3)nc12 CHEMBL3641140 IC50 3.0 nM
Cc1ccc(C(=O)Nc2cc(OCCN3CCOCC3)cc(C(F)(F)F)c2)cc1Nc1ncnc2cnc(N3CCOCC3)nc12 CHEMBL3641144 IC50 3.0 nM
COc1ccc(NC(=O)c2ccc(C)c(Nc3ncnc4cnc(N(C)CC5CCCO5)nc34)c2)cc1C(F)(F)F CHEMBL3641158 IC50 3.0 nM
COc1ccc(NC(=O)c2ccc(C)c(Nc3ncnc4cnc(N(C)C5CCOC5)nc34)c2)cc1C(F)(F)F CHEMBL3641163 IC50 3.0 nM
COc1ccc(NC(=O)c2ccc(C)c(Nc3ncnc4cnc(N5CCN(CC6CCCN(C)C6)CC5)nc34)c2)cc1C(F)(F)F CHEMBL3641169 IC50 3.0 nM
COc1ncc2ncnc(Nc3cc(C(=O)Nc4cc(C(C)(C)C)n[nH]4)ccc3C)c2n1 CHEMBL3641186 IC50 3.0 nM
Cc1ccc(C(=O)Nc2cc(C(C)(C)C)n[nH]2)cc1Nc1ncnc2cnc(N3CCC(CN4CCCC4)CC3)nc12 CHEMBL3641204 IC50 3.0 nM
Cc1ccc(C(=O)Nc2ccnc(C(C)(C)C)c2)cc1Nc1ncnc2cnc(N3CCC(CN4CCCC4)CC3)nc12 CHEMBL3641208 IC50 3.0 nM
Cc1ccc(C(=O)Nc2ccnc(C(C)(C)C)c2)cc1Nc1ncnc2cnc(N3CCC(CCN(C)C)CC3)nc12 CHEMBL3641210 IC50 3.0 nM
Cc1ccc(NC(=O)c2cc(N3CCN(C)CC3)cc(C(F)(F)F)c2)cc1Nc1ncnc2cnc(N(C)C)nc12 CHEMBL3641221 IC50 3.0 nM
COc1ccc(C(=O)Nc2ccc(C)c(Nc3ncnc4cnc(N(C)C)nc34)c2)cc1C(F)(F)F CHEMBL3641222 IC50 3.0 nM
COc1ncc2ncnc(Nc3cc(NC(=O)c4cc(N5CCN(C)CC5)cc(C(F)(F)F)c4)ccc3C)c2n1 CHEMBL3641242 IC50 3.0 nM
Cc1ccc(NC(=O)c2cc(N3CCN(C)CC3)cc(C(C)(C)C#N)c2)cc1Nc1ncnc2cnc(N3CCOCC3)nc12 CHEMBL3643294 IC50 3.0 nM
Cc1ccc(NC(=O)c2ccc(C(C)(C)C)o2)cc1-n1cc(-c2cncc(N3CCN(C(C)(C)C)CC3)c2)nn1 CHEMBL3903342 IC50 3.0 nM
CCN1CCN(c2cncc(-c3cn(-c4cc(NC(=O)c5ccc(C(C)(C)C)o5)ccc4C)nn3)c2)CC1 CHEMBL3983429 IC50 3.0 nM
Cc1cc(-c2cc(O)ccc2Cl)cc2nnc(Nc3ccc(OCCN4CCCC4)cc3)nc12 CHEMBL400402 Kd apparent 3.0 nM
CC(=O)Nc1cn2cc(-c3cc(NC(=O)c4cc(N5CCN(C)C[C@@H]5C)cc(C(F)(F)F)c4)ccc3C)ccc2n1 CHEMBL4208527 IC50 3.0 nM
Cc1ccc(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1-c1ccnc(N2CCOCC2)c1 CHEMBL3912517 IC50 3.002 nM
O=C(Nc1cccc(Nc2ncccc2-c2ncnc3[nH]cnc23)c1)c1ccc(Cl)c(C(F)(F)F)c1 CHEMBL3354393 IC50 3.03 nM
Cc1ccc(NC(=O)c2cccc(C3(C#N)CC3)c2Cl)cc1-c1cc(N2CCOCC2)nc(N2CCOCC2)n1 CHEMBL3951027 IC50 3.05 nM
Cn1cc(-c2ccc3c(c2)CC/C3=N\O)c(-c2ccncn2)n1 CHEMBL497701 IC50 3.1 nM
CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]c(-c4cccc(F)c4)nc3c2)c1F CHEMBL2436805 IC50 3.1 nM
O=C1CCc2c(Oc3ccc4c(c3)C[C@H](NC(=O)c3cccc(C(F)(F)F)c3)CC4)ccnc2N1 CHEMBL3765596 IC50 3.1 nM
O=C1CCc2c(Oc3ccc4c(c3)C3C(O4)C3c3nc4ccccc4[nH]3)ccnc2N1 CHEMBL3955401 IC50 3.1 nM
Cc1ncc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)c(=O)n(C)c1 CHEMBL3986273 IC50 3.112 nM
COC(=O)N[C@@H](C)CNc1nccc(-c2nc(C(C)(C)C)[nH]c2-c2cc(C)cc(NS(=O)(=O)C(C)C)c2)n1 CHEMBL3651621 IC50 3.12 nM
Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)c(=O)n(C)n1 CHEMBL3938679 IC50 3.127 nM
Cc1ccc(NC(=O)c2ccnc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)c(=O)n(C)n1 CHEMBL3940726 IC50 3.139 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCO[C@@H](C)C2)nc(N2CCOCC2)n1 CHEMBL3973655 IC50 3.14 nM
Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCS(=O)(=O)CC2)nc(N2CCOCC2)n1 CHEMBL3940522 IC50 3.146 nM
Cc1ccc(C(=O)Nc2ccc(Cl)c(C(F)(F)F)c2)cc1Nc1ncccc1-c1ncnc2[nH]cnc12 CHEMBL3354380 IC50 3.15 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CC3CC2CO3)nc(N2CCOCC2)n1 CHEMBL3978883 IC50 3.162 nM
CN(C)Cc1cc(C(=O)N[C@H]2CCc3ccc(Oc4ccnc(NC(=O)C5CC5)c4)cc3C2)cc(C(F)(F)F)c1 CHEMBL1688875 IC50 3.2 nM
c1cc(-c2nn(C3CCCNCC3)cc2-c2ccc3c(c2)Cc2c[nH]nc2-3)ccn1 CHEMBL1780169 IC50 3.2 nM
F[C@H]1CCNC[C@H]1n1cc(-c2ccc3c(c2)Cc2c[nH]nc2-3)c(-c2ccncc2)n1 CHEMBL1780179 IC50 3.2 nM
CCCS(=O)(=O)Nc1ccc(F)c(NC(=O)c2csc3c(N)ncnc23)c1F CHEMBL2047876 IC50 3.2 nM
CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(-c4ccc(Cl)cc4)cc23)c1F CHEMBL1229517 IC50 3.2 nM
CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]c(-c4ccncc4)nc3c2)c1F CHEMBL2436797 IC50 3.2 nM
O=C1CCc2c(Oc3ccc4c(c3)C3C(O4)C3c3nc(-c4ccccc4)no3)ccnc2N1 CHEMBL3946213 IC50 3.2 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N(C)C)nc(N2CCOCC2)c1 CHEMBL3972341 IC50 3.222 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cnc(O[C@@H](C)C#N)c(N2CCOCC2)c1 CHEMBL3900202 IC50 3.295 nM
CC(C)NCc1cc(NC(=O)[C@H]2CCc3ccc(Oc4ccnc5c4CCC(=O)N5)cc3C2)cc(C(F)(F)F)c1 CHEMBL1688873 IC50 3.3 nM
O=C1CCc2c(Oc3ccc4c(c3)C3C(O4)C3c3nc(-c4ccccc4Cl)c[nH]3)ccnc2N1 CHEMBL3945405 IC50 3.3 nM
O=C(Nc1ccc(Oc2ccnc(NC(=O)C3CC3)c2)cc1)Nc1ccc2c(c1)C(F)(F)CCO2 CHEMBL3969197 IC50 3.3 nM
COc1ccc(Cn2ncc(NC(=O)c3cc(NC(=O)Nc4ccc(Cl)c(C(F)(F)F)c4)ccc3C)c2N)cc1 CHEMBL1684800 IC50 3.32 nM
Cc1ccc2c(Nc3ccc(Cl)cc3)nccc2c1Nc1ncccc1-c1ccncn1 CHEMBL565884 IC50 3.4 nM
CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]cc(Br)c3c2)c1F CHEMBL1822246 IC50 3.4 nM
CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]c(-c4ccc(F)c(F)c4)nc3c2)c1F CHEMBL2436802 IC50 3.4 nM
Cc1cc2[nH]c(C3[C@H]4c5cc(Oc6ccnc7c6CCC(=O)N7)ccc5O[C@@H]34)nc2cc1F CHEMBL4112452 IC50 3.4 nM
CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(-c4ccc(C(=O)NCCOCCOCCOCCOc5cc(-c6scnc6C)ccc5CNC(=O)[C@@H]5C[C@@H](O)CN5C(=O)[C@H](C(C)C)N5Cc6ccccc6C5=O)cc4)cc23)c1F CHEMBL5208447 IC50 3.4 nM
CCN1CCN(c2cc(C(=O)Nc3ccc(C)c(-c4cc(N5CCOCC5)nc(N5CCOCC5)n4)c3)cc(C(F)(F)F)c2)CC1 CHEMBL3929795 IC50 3.433 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)nc(NS(C)(=O)=O)n1 CHEMBL3977938 IC50 3.454 nM
O/N=C1\CCc2cc(-c3cn(C4CCCC4)nc3-c3ccncc3)ccc21 CHEMBL503089 IC50 3.46 nM
CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]nc(OCC4CCC4)c3c2)c1F CHEMBL1822253 IC50 3.5 nM
CC(C)(C#N)c1cccc(C(=O)Nc2ccc(F)c(C(=O)Nc3cnc4[nH]ncc4c3)c2F)c1 CHEMBL2151064 IC50 3.5 nM
O=C(c1c(F)ccc(NS(=O)(=O)N2CC[C@H](F)C2)c1F)c1c[nH]c2ncc(-c3cnc(C4CC4)nc3)cc12 CHEMBL4211715 IC50 3.5 nM
Cc1ccc(C(=O)Nc2ccc(Cl)c(C(F)(F)F)c2)cc1NC(=O)C1(c2ncnc3[nH]ccc23)CC1 CHEMBL4438236 IC50 3.5 nM
CC(=O)N1CCN(c2ccc(Nc3nccc(-c4sc(C(C)C)nc4-c4cccc(NS(=O)(=O)c5ccccc5)c4)n3)cn2)CC1 CHEMBL1807711 IC50 3.6 nM
O=C(Nc1ccc(Oc2ccnc(NC(=O)C3CC3)c2)c(F)c1)Nc1ccc(Cl)c(C(F)(F)F)c1 CHEMBL3947363 IC50 3.6 nM
CC(C)(C)c1nc(-c2cc(Cl)cc(NS(=O)(=O)c3cc(F)ccc3F)c2F)c(-c2ccnc(N)n2)s1 CHEMBL5202550 IC50 3.6 nM
Cc1ccc(C(=O)Nc2ccc(Cl)c(Br)c2)cc1Nc1ncccc1-c1ncnc2[nH]cnc12 CHEMBL3354386 IC50 3.62 nM
Cc1ncc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cnc(OC(C)C)c(N2CCOCC2)c1 CHEMBL3902816 IC50 3.64 nM
c1cc(-c2nn(C3CCCNC3)cc2-c2ccc3c(c2)Cc2c[nH]nc2-3)ccn1 CHEMBL1780168 IC50 3.7 nM
Cc1ccc2nc(C3C4Oc5ccc(Oc6ccnc7c6CCC(=O)N7)cc5C43)[nH]c2c1 CHEMBL3898602 IC50 3.7 nM
O=C1CCc2c(Oc3ccc4c(c3)C3C(O4)C3c3nc(-c4ccncc4)c[nH]3)ccnc2N1 CHEMBL3941872 IC50 3.7 nM
O=C(Nc1ccc(Oc2ccnc(NC(=O)C3CC3)c2)cc1)Nc1cc(OCC2CNC2)cc(C(F)(F)F)c1 CHEMBL3968631 IC50 3.7 nM
Nc1nccc(C2=C(c3cccc(NS(=O)(=O)c4c(F)cccc4F)c3Cl)C(=O)C3(CCCC3)O2)n1 CHEMBL3939274 IC50 3.7 nM
CC(=O)Nc1cc(-c2sc(C3CCN(C4CC4)CC3)nc2-c2cccc(NS(=O)(=O)c3cc(F)ccc3F)c2F)ccn1 CHEMBL5283675 IC50 3.7 nM
CN1CCCN(CCNc2nccc(-c3c(-c4cccc(O)c4)nc4sccn34)n2)S1(=O)=O CHEMBL5079413 IC50 3.77 nM
COc1ncc(-c2cc(NC(=O)c3ccnc(C(C)(C)C#N)c3)ccc2C)cc1N1CCOCC1 CHEMBL3904596 IC50 3.782 nM
Cc1ncc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cnc(OCCO)c(N2CCOCC2)c1 CHEMBL3984244 IC50 3.786 nM
Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)c(=O)n(C)c1 CHEMBL3920039 IC50 3.792 nM
Fc1ccc(-c2c(-c3ccncc3)nn3c(C4CC5CCC(C4)N5)ccnc23)c2cn[nH]c12 CHEMBL584527 IC50 3.8 nM
F[C@H]1CNCC[C@H]1n1cc(-c2ccc3c(c2)Cc2c[nH]nc2-3)c(-c2ccncc2)n1 CHEMBL1780178 IC50 3.8 nM
CC(C)c1nc(-c2ccc(F)c(NS(=O)(=O)c3c(F)cccc3F)c2)c(-c2ccnc(Nc3ccc(N4CCOCC4)nc3)n2)s1 CHEMBL1808264 IC50 3.8 nM
CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]nc(C4CC4)c3c2)c1Cl CHEMBL1939071 IC50 3.8 nM
COc1cc(-c2ccc3ncnc(Nc4cc(O)c(F)cc4F)c3c2)ccc1O CHEMBL3665859 IC50 3.8 nM
CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(-c4ccc(CNC(=O)CCCCOCCOCCOCCOc5cc(-c6scnc6C)ccc5CNC(=O)[C@@H]5C[C@@H](O)CN5C(=O)[C@H](C(C)C)N5Cc6ccccc6C5=O)cc4)cc23)c1F CHEMBL5170982 IC50 3.8 nM
CCn1cc(-c2cc(NC(=O)c3cccc(C(F)(F)F)c3)ccc2C)cc(N2CCOCC2)c1=O CHEMBL3890463 IC50 3.831 nM
COc1ncc(N2CCOCC2)cc1-c1cc(NC(=O)c2cccc(C(F)(F)F)c2)ccc1C CHEMBL3922193 IC50 3.877 nM
CCn1cc(-c2ccnc3[nH]ccc23)c(-c2cccc(NC(=O)Nc3cc(C(F)(F)F)ccc3F)c2)n1 CHEMBL526268 IC50 3.9 nM
COC(=O)N[C@@H](C)CNc1nccc(-c2cn(C(C)C)nc2-c2c(F)ccc(NS(C)(=O)=O)c2F)n1 CHEMBL3917315 IC50 3.9 nM
Cc1ccc(CC[C@@H]2CCN2C)c(NC(=O)Nc2cccc(Oc3ccc4nc[nH]c(=O)c4c3)c2)c1 CHEMBL4436625 IC50 3.9 nM
O/N=C1\CCc2cc(-c3cn([C@H]4CCC[C@H]4O)nc3-c3ccncc3)ccc21 CHEMBL498343 IC50 3.91 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)c(=O)n(CCS(C)(=O)=O)c1 CHEMBL3945747 IC50 3.933 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)c(=O)n(C(C)C)c1 CHEMBL3913790 IC50 3.957 nM
Oc1cccc(-c2c(-c3ccncc3)nn3c(C4CC5CCC(C4)N5)ccnc23)c1 CHEMBL583025 IC50 4.0 nM
O=C(Nc1ccc(Oc2ccnc3[nH]c(=O)cnc23)cc1F)Nc1cc(C(F)(F)F)ccc1F CHEMBL1214612 IC50 4.0 nM
CSc1cc(Oc2ccnc3[nH]c(=O)cnc23)ccc1NC(=O)Nc1ccc(Cl)c(C(F)(F)F)c1 CHEMBL1213952 IC50 4.0 nM
CSc1cc(Oc2ccnc3[nH]c(=O)cnc23)ccc1NC(=O)Nc1cc(C(F)(F)F)ccc1F CHEMBL1213999 IC50 4.0 nM
Cc1nc2c(Oc3ccc(NC(=O)Nc4cc(C(F)(F)F)ccc4F)c4ccccc34)ccnc2[nH]c1=O CHEMBL1214058 IC50 4.0 nM
c1cnc(-c2oc3cnccc3c2Nc2ccc3c(c2)Cc2c[nH]nc2-3)nc1 CHEMBL1667902 IC50 4.0 nM
CC(C)NC(=O)c1oc2cnccc2c1Nc1ccc(Cl)c(O)c1 CHEMBL1667913 IC50 4.0 nM
O/N=C1/CCc2cc(Nc3c(-c4ccco4)nc4cnccn34)ccc21 CHEMBL1668908 IC50 4.0 nM
CN(C)Cc1cc(NC(=O)[C@H]2CCc3ccc(Oc4ccnc(NC(=O)C5CC5)c4)cc3C2)cc(C(F)(F)F)c1 CHEMBL1688871 IC50 4.0 nM
CNC(=O)c1cc(Oc2ccc3sc(Nc4cccc(C(C)(C)C)c4)nc3c2)ccn1 CHEMBL1778403 IC50 4.0 nM
CC(C)c1cccc(Nc2nc3cc(Oc4ccnc(C(N)=O)c4)ccc3o2)c1 CHEMBL1778401 IC50 4.0 nM
O=C(c1ccc(-c2ccc3c(c2)CNC3)s1)N1N=C(c2cccnc2)CC1c1ccccc1O CHEMBL1779294 IC50 4.0 nM
O=C(c1ccc(-c2ccc3c(c2)CNCC3)s1)N1N=C(c2cccnc2)CC1c1ccccc1O CHEMBL1779292 IC50 4.0 nM
NCc1ccccc1-c1ccc(C(=O)N2N=C(c3cncc(N)c3)CC2c2c(O)cccc2F)s1 CHEMBL1779281 IC50 4.0 nM
CC(C)c1nc(-c2cccc(NC(=O)c3c(F)cccc3F)c2)c(-c2ccnc(Nc3ccc4c(c3)CN(C)CC4)n2)s1 CHEMBL1807709 IC50 4.0 nM
CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]nc(Br)c3c2)c1F CHEMBL1822241 IC50 4.0 nM
NC(=O)c1sc2nc(NC3CC3)nc(-c3cccc(O)c3F)c2c1N CHEMBL1934516 IC50 4.0 nM
Cc1ccc(-c2nc(NC3CC3)nc3sc(C(N)=O)c(N)c23)cc1O CHEMBL1934515 IC50 4.0 nM
Cc1ccc(NC(=O)Nc2cccc(-c3nc(NC4CC4)nc4sc(C(N)=O)c(N)c34)c2)cc1 CHEMBL1934645 IC50 4.0 nM
C[C@@H](NC1=CC(=O)CCC1)c1ccc(Nc2ncc3cc(-c4ccncc4)ccc3n2)cc1 CHEMBL2335903 IC50 4.0 nM
CCCS(=O)(=O)Nc1ccc(F)c(Nc2ccc3ncncc3c2)c1Cl CHEMBL3236193 IC50 4.0 nM
CC(=O)Nc1cc(Oc2ccc3c(c2)nc(Nc2ccc(C(C)C)cc2)n3C)ccn1 CHEMBL3335378 IC50 4.0 nM
CC(=O)Nc1cc(Oc2ccc3c(c2)nc(Nc2ccc(C(F)(F)F)cc2)n3C)ccn1 CHEMBL3335380 IC50 4.0 nM
CNS(=O)(=O)c1cccc(Nc2ncnc3[nH]cc(-c4ccccc4)c23)c1 CHEMBL3612667 IC50 4.0 nM
CNS(=O)(=O)c1cccc(Nc2ncnc3[nH]cc(-c4ccc(Cl)cc4)c23)c1 CHEMBL3613178 IC50 4.0 nM
CNS(=O)(=O)c1cccc(Nc2ncnc3[nH]cc(-c4ccc(OC)cc4)c23)c1 CHEMBL3613179 IC50 4.0 nM
O=C1CCc2c(Oc3ccc4c(c3)C[C@H](NC(=O)c3cc(CN5CCOCC5CO)cc(C(F)(F)F)c3)CC4)ccnc2N1 CHEMBL3764275 IC50 4.0 nM
O=S(=O)(Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F)C1CCC1 CHEMBL3798630 IC50 4.0 nM
CS(=O)(=O)Nc1cc(Cl)cc(-c2[nH]c(C3CC3)nc2-c2ccnc(N)n2)c1F CHEMBL3651663 IC50 4.0 nM
CS(=O)(=O)Nc1cccc(-c2[nH]c(C3CC3)nc2-c2ccnc(NCCC#N)n2)c1F CHEMBL3651687 IC50 4.0 nM
CCCS(=O)(=O)Nc1cc(F)cc(-c2[nH]c(C3CC3)nc2-c2ccncn2)c1Cl CHEMBL3651692 IC50 4.0 nM
Cc1ccc(C(=O)Nc2cc(N3CCN(C)CC3)cc(C(F)(F)F)c2)cc1Nc1ncnc2ccc(N3CCOCC3)nc12 CHEMBL3659914 IC50 4.0 nM
Cc1ccc(C(=O)Nc2cc(CN3CCCC3)cc(C(F)(F)F)c2)cc1Nc1ncnc2ccc(N3CCOCC3)nc12 CHEMBL3659916 IC50 4.0 nM
Cc1ccc(NC(=O)c2cccc(C(C)(C)C#N)c2)cc1Nc1ncnc2ccc(N3CCOCC3)nc12 CHEMBL3659963 IC50 4.0 nM
Cc1ccc(C(=O)Nc2cc(C(C)(C)C)n[nH]2)cc1Nc1ncnc2c(N)nc(N3CCN(CC4CCN(C)CC4)CC3)nc12 CHEMBL3689912 IC50 4.0 nM
Cc1ccc(C(=O)Nc2cc(C(C)(C)C)n[nH]2)cc1Nc1ncnc2c(N)nc(N3C[C@H]4C[C@@H]3CN4C)nc12 CHEMBL3689935 IC50 4.0 nM
Cc1ccc(C(=O)Nc2cc(C(C)(C)C)n[nH]2)cc1Nc1ncnc2c(N)nc(N3CCN(CC(C)C)CC3)nc12 CHEMBL3689936 IC50 4.0 nM
Cc1ccc(C(=O)Nc2cc(C(C)(C)C)n[nH]2)cc1Nc1ncnc2c(N)nc(N3CCN4CCCCC4C3)nc12 CHEMBL3689942 IC50 4.0 nM
Cc1ccc(C(=O)Nc2cc(N(C)CCN(C)C)cc(C(F)(F)F)c2)cc1Nc1ncnc2c(N)nc(N3CC[C@H](F)C3)nc12 CHEMBL3694043 IC50 4.0 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1Nc1ncnc2c(N)nc(N3CCN(CC4CCN(C)CC4)CC3)nc12 CHEMBL3694059 IC50 4.0 nM
COc1ccc(NC(=O)c2ccc(Cl)c(Nc3ncnc4cnc(NCCCN5CCOCC5)nc34)c2)cc1C(F)(F)F CHEMBL3694074 IC50 4.0 nM
COc1ccc(C(=O)Nc2ccc(OC)c(C(F)(F)F)c2)cc1Nc1ncnc2cnc(N(C)CCN(C)C)nc12 CHEMBL3694081 IC50 4.0 nM
COc1ccc(NC(=O)c2ccc(F)c(Nc3ncnc4cnc(N5CCOCC5)nc34)c2)cc1C(F)(F)F CHEMBL3694100 IC50 4.0 nM
CN1CCCN(c2ncc3ncnc(Nc4cc(C(=O)Nc5cc(C(C)(C)C)on5)ccc4Cl)c3n2)CC1 CHEMBL3694133 IC50 4.0 nM
CN1CCN(c2ncc3ncnc(Nc4cc(C(=O)Nc5cc(C(C)(C)C)on5)ccc4Cl)c3n2)CC1 CHEMBL3694135 IC50 4.0 nM
CC(C)(C)c1cc(NC(=O)c2ccc(Cl)c(Nc3ncnc4cnc(N5CCCCC5)nc34)c2)no1 CHEMBL3694136 IC50 4.0 nM
CC(C)(C)c1cc(NC(=O)c2ccc(F)c(Nc3ncnc4cnc(N5CCOCC5)nc34)c2)no1 CHEMBL3694152 IC50 4.0 nM
COc1ccc(C(=O)Nc2cc(C(C)(C)C)on2)cc1Nc1ncnc2cnc(N(C)CCN3CCCC3)nc12 CHEMBL3639930 IC50 4.0 nM
Cc1ccc(C(=O)Nc2cc(CN3CCCC3)cc(C(F)(F)F)c2)cc1Nc1ncnc2cnc(N3CCC3)nc12 CHEMBL3694162 IC50 4.0 nM
Cc1ccc(C(=O)Nc2cc(CN3CCCC3)cc(C(F)(F)F)c2)cc1Nc1ncnc2cnc(N3CCC(F)(F)CC3)nc12 CHEMBL3694164 IC50 4.0 nM
Cc1ccc(C(=O)Nc2ccc(N(C)CCN(C)C)c(C(F)(F)F)c2)cc1Nc1ncnc2cnc(N3CCC(F)CC3)nc12 CHEMBL3694187 IC50 4.0 nM
Cc1ccc(C(=O)Nc2ccc(N(C)CCN(C)C)c(C(F)(F)F)c2)cc1Nc1ncnc2cnc(NCc3ccccn3)nc12 CHEMBL3694197 IC50 4.0 nM
Cc1ccc(C(=O)Nc2cc(OCCN(C)C)cc(C(F)(F)F)c2)cc1Nc1ncnc2cnc(NCc3ccccn3)nc12 CHEMBL3694216 IC50 4.0 nM
Cc1ccc(C(=O)Nc2cc(N(C)CCN(C)C)cc(C(F)(F)F)c2)cc1Nc1ncnc2cnc(NCc3ccccc3)nc12 CHEMBL3694228 IC50 4.0 nM
CCN(CC)c1ncc2ncnc(Nc3cc(C(=O)Nc4cc(N(C)CCN(C)C)cc(C(F)(F)F)c4)ccc3C)c2n1 CHEMBL3697723 IC50 4.0 nM
Cc1ccc(C(=O)Nc2cc(N(C)CCN(C)C)cc(C(F)(F)F)c2)cc1Nc1ncnc2cnc(NCCc3ccccc3)nc12 CHEMBL3639965 IC50 4.0 nM
Cc1ccc(C(=O)Nc2ccc3c(c2)C(C)(C)C(=O)N3CCN2CCCC2)cc1Nc1ncnc2cnc(N3CC[C@@H](F)C3)nc12 CHEMBL3697750 IC50 4.0 nM
Cc1ccc(C(=O)Nc2ccc3c(c2)C(C)(C)C(=O)N3CCN2CCCC2)cc1Nc1ncnc2cnc(N3CCCCC3)nc12 CHEMBL3697757 IC50 4.0 nM
Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1ncnc2cnc(N(C)CCN(C)C)nc12 CHEMBL3697778 IC50 4.0 nM
COc1ccc(C(C)(C)C)cc1NC(=O)c1ccc(C)c(Nc2ncnc3cnc(N(C)CCN(C)C)nc23)c1 CHEMBL3697786 IC50 4.0 nM
Cc1ccc(C(=O)Nc2ccc(F)c(C(F)(F)F)c2)cc1Nc1ncnc2cnc(N3CCCC3)nc12 CHEMBL3697811 IC50 4.0 nM
Cc1ccc(C(=O)Nc2ccc(Cl)c(C(F)(F)F)c2)cc1Nc1ncnc2cnc(N3CCN(C)CC3)nc12 CHEMBL3697845 IC50 4.0 nM
COc1ccc(C(C)(C)C)cc1NC(=O)c1ccc(C)c(Nc2ncnc3cnc(N4CCOCC4)nc23)c1 CHEMBL3697851 IC50 4.0 nM
Cc1ccc(C(=O)Nc2cccc(N(C)C)c2)cc1Nc1ncnc2cnc(N3CCOCC3)nc12 CHEMBL3697854 IC50 4.0 nM
Cc1ccc(C(=O)Nc2cccc(OC(F)(F)F)c2)cc1Nc1ncnc2cnc(N3CCCCC3)nc12 CHEMBL3697876 IC50 4.0 nM
Cc1ccc(C(=O)Nc2ccc(C#N)c(C(F)(F)F)c2)cc1Nc1ncnc2cnc(N3CCOCC3)nc12 CHEMBL3697884 IC50 4.0 nM
Cn1nc(C(C)(C)C)cc1NC(=O)c1cc(Cl)cc(Nc2ncnc3cnc(N4CCCC4)nc23)c1 CHEMBL3697918 IC50 4.0 nM
CC(C)(C#N)c1cccc(NC(=O)c2ccc(F)c(Nc3ncnc4cnc(N5CCOCC5)nc34)c2)c1 CHEMBL3697923 IC50 4.0 nM
COCCN1CCN(c2ncc3ncnc(Nc4cc(C(=O)Nc5cc(C(C)(C)C)on5)ccc4F)c3n2)CC1 CHEMBL3697935 IC50 4.0 nM
CC(C)(C)c1cc(NC(=O)c2ccc(F)c(Nc3ncnc4cnc(N5CCN(CC6CC6)CC5)nc34)c2)no1 CHEMBL3697937 IC50 4.0 nM
CN1CCC(N(C)c2ncc3ncnc(Nc4cc(C(=O)Nc5cc(C(C)(C)C)on5)ccc4F)c3n2)C1 CHEMBL3641027 IC50 4.0 nM
CCN1CCN(c2cc(NC(=O)c3ccc(C)c(Nc4ncnc5cnc(N6CC[C@H](F)C6)nc45)c3)cc(C(F)(F)F)c2)CC1 CHEMBL3641065 IC50 4.0 nM
COc1ccc(NC(=O)c2ccc(C)c(Nc3ncnc4cnc(N5CCN(CC(C)C)CC5)nc34)c2)cc1C(F)(F)F CHEMBL3641070 IC50 4.0 nM
Cc1cn(-c2cc(NC(=O)c3ccc(C)c(Nc4ncnc5cnc(N6CC[C@H](F)C6)nc45)c3)cc(C(F)(F)F)c2)cn1 CHEMBL3641077 IC50 4.0 nM
Cc1ccc(C(=O)Nc2cc(N3CCN(C)CC3)cc(C(F)(F)F)c2)cc1Nc1ncnc2cnc(N3CC[C@H](F)C3)nc12 CHEMBL3641080 IC50 4.0 nM
Cc1ccc(C(=O)Nc2cc(N3CCN(CC(C)C)CC3)cc(C(F)(F)F)c2)cc1Nc1ncnc2cnc(N3CCOCC3)nc12 CHEMBL3641083 IC50 4.0 nM
COCCN(C)c1ncc2ncnc(Nc3cc(C(=O)Nc4cc(C(C)(C)C)n[nH]4)ccc3C)c2n1 CHEMBL3641092 IC50 4.0 nM
Cc1ccc(C(=O)Nc2cc(C(C)(C)C)on2)cc1Nc1ncnc2cnc(N(C)CC3CCCCO3)nc12 CHEMBL3641096 IC50 4.0 nM
Cc1ccc(C(=O)Nc2cc(C(C)(C)C)on2)cc1Nc1ncnc2cnc(N3CCN(CC4CCOC4)CC3)nc12 CHEMBL3641098 IC50 4.0 nM
Cc1ccc(C(=O)Nc2cc(C(C)(C)C)on2)cc1Nc1ncnc2cnc(N3CCN(C4CCN(C)CC4)CC3)nc12 CHEMBL3641102 IC50 4.0 nM
Cc1ccc(C(=O)Nc2cc(C(C)(C)C)on2)cc1Nc1ncnc2cnc(N3CCN(CC(C)C)CC3)nc12 CHEMBL3641110 IC50 4.0 nM
Cc1ccc(C(=O)Nc2cc(N3CCN(C)CC3)c(F)c(C(F)(F)F)c2)cc1Nc1ncnc2cnc(NC3CCOC3)nc12 CHEMBL3641121 IC50 4.0 nM
Cc1ccc(C(=O)Nc2cc(N3CCN(C)CC3)c(F)c(C(F)(F)F)c2)cc1Nc1ncnc2cnc(N3CC[C@H](F)C3)nc12 CHEMBL3641126 IC50 4.0 nM
Cc1ccc(C(=O)Nc2cc(N3CCN(CCO)CC3)cc(C(F)(F)F)c2)cc1Nc1ncnc2cnc(N3CCOCC3)nc12 CHEMBL3641141 IC50 4.0 nM
COCCN1CCN(c2ncc3ncnc(Nc4cc(C(=O)Nc5cc(OC)cc(C(F)(F)F)c5)ccc4C)c3n2)CC1 CHEMBL3641150 IC50 4.0 nM
COc1ccc(NC(=O)c2ccc(C)c(Nc3ncnc4cnc(N5CCC[C@H]5CO)nc34)c2)cc1C(F)(F)F CHEMBL3641161 IC50 4.0 nM
COc1ccc(NC(=O)c2ccc(C)c(Nc3ncnc4cnc(N5C[C@@H](C)O[C@@H](C)C5)nc34)c2)cc1C(F)(F)F CHEMBL3641165 IC50 4.0 nM
COc1ccc(NC(=O)c2ccc(C)c(Nc3ncnc4cnc(N5CCN(C6CCN(C)CC6)CC5)nc34)c2)cc1C(F)(F)F CHEMBL3641172 IC50 4.0 nM
Cc1ccc(NC(=O)c2cc(N3CCN(C)CC3)cc(C(F)(F)F)c2)cc1Nc1ncnc2cnc(N(C)CCCN(C)C)nc12 CHEMBL3641225 IC50 4.0 nM
CC(=O)N1CCN(c2ncc3ncnc(Nc4cc(NC(=O)c5cccc(C(C)(C)C#N)c5)ccc4C)c3n2)CC1 CHEMBL3641236 IC50 4.0 nM
Cc1ccc(NC(=O)c2cccc(C(C)(C)C#N)c2)cc1Nc1ncnc2cnc(N(C)CC3CCOCC3)nc12 CHEMBL3641239 IC50 4.0 nM
Cc1ccc(C(=O)Nc2cc(CN3CCCC3)cc(C(F)(F)F)c2)cc1Nc1ncnc2cncnc12 CHEMBL3643296 IC50 4.0 nM
CCCS(=O)(=O)Nc1ccc(F)c(-n2cc(-c3cncnc3)c3nc(N(C)C4CCN(C)CC4)ncc32)c1F CHEMBL3702561 IC50 4.0 nM
NC(=O)c1ccc2nc(C3C4Oc5ccc(Oc6ccnc7c6CCC(=O)N7)cc5C43)[nH]c2c1 CHEMBL3892591 IC50 4.0 nM
Cc1ccc(C(=O)Nc2cc(C(F)(F)F)ccn2)cc1-n1cc(-c2cncc(N3C[C@@H]4C[C@H]3CN4)c2)nn1 CHEMBL3897088 IC50 4.0 nM
Cc1ccc(C(=O)Nc2cc(C(F)(F)F)ccn2)cc1-n1cc(-c2cncc(N(C)C3CCN(C)C3)c2)nn1 CHEMBL3955018 IC50 4.0 nM
Cc1ccc(NC(=O)c2cc(C(F)(F)F)ccn2)cc1-n1cc(-c2cncc(N3CCN(C)CC3)c2)nn1 CHEMBL3980110 IC50 4.0 nM
Cc1ccc(NC(=O)c2ccc(C(C)(C)C)s2)cc1-n1cc(-c2cncc(N3CCNCC3)c2)nn1 CHEMBL3932260 IC50 4.0 nM
CN(C)CCn1cc(-c2ccc3c(c2)CC/C3=N\O)c(-c2ccncc2)n1 CHEMBL498327 IC50 4.02 nM
Cc1ncc(NC(=O)c2ccnc(C(C)(F)F)c2)cc1-c1ccnc(N2CCOCC2)c1 CHEMBL3983865 IC50 4.089 nM
Cn1cc(-c2ccc3c(c2)CC/C3=N\O)c(-c2cnco2)n1 CHEMBL496478 IC50 4.1 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cnc(OC(C)C)c(N2CCOCC2)c1 CHEMBL3941778 IC50 4.173 nM
Oc1cc(-c2[nH]c(-c3ccco3)nc2-c2ccncc2)ccc1Cl CHEMBL371952 Kd 4.2 nM
Clc1ccc(Nc2c(-c3ncccn3)oc3cnccc23)c2cn[nH]c12 CHEMBL1667916 IC50 4.2 nM
CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]nc(OCC4COC4)c3c2)c1F CHEMBL1822254 IC50 4.2 nM
CCn1c(=O)c(-c2cc(NC(=O)NCCC(C)(C)C)c(F)cc2C)cc2cnc(NC)cc21 CHEMBL3577116 IC50 4.2 nM
CCN(C)S(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(-c4cnc(C5CC5)nc4)cc23)c1F CHEMBL4206836 IC50 4.2 nM
Cc1ccc(NC(=O)Nc2ccc(Cl)c(C(F)(F)F)c2)cc1Nc1ncccc1-c1ncnc2[nH]cnc12 CHEMBL3354378 IC50 4.21 nM
O=S(=O)(NCCCNc1nccc(-c2[nH]c(-c3ccccc3)nc2-c2ccc(Cl)c(O)c2)n1)c1ccccc1 CHEMBL4797100 IC50 4.25 nM
NCCCc1n[nH]c2c(Cl)ccc(Nc3c(-c4ncccn4)oc4cnccc34)c12 CHEMBL1667865 IC50 4.3 nM
CNc1cc2nc(C)c(-c3cc(NC(=O)NCCC(C)(C)C)ccc3C)cc2cn1 CHEMBL3577118 IC50 4.3 nM
CC(C)n1cc(-c2ccnc(N)n2)c(-c2cc(Cl)cc(NS(C)(=O)=O)c2F)n1 CHEMBL3903732 IC50 4.3 nM
CNc1cc(C2(C(=O)Nc3cc(NC(=O)c4ccc(Cl)c(C(F)(F)F)c4)ccc3C)CC2)ncn1 CHEMBL4073430 IC50 4.3 nM
Nc1cccc(-c2nc3sccn3c2-c2ccnc(NCCCCNS(=O)(=O)c3ccc(Br)cc3)n2)c1 CHEMBL4745503 IC50 4.31 nM
Oc1c(Br)cc(C=C2c3cc(I)ccc3NC2O)cc1Br CHEMBL1794051 IC50 4.33 nM
Cc1c[nH]nc1-c1ccc(-c2cn(C)nc2-c2ccncc2)cc1 CHEMBL498468 IC50 4.4 nM
CCN1C2CCC1CC(c1ccnc3c(-c4ccc(Cl)c5[nH]ncc45)c(-c4ccncc4)nn13)C2 CHEMBL583245 IC50 4.4 nM
CCOC(=O)N1C2CCC1CC(c1ccnc3c(-c4ccc(C(F)(F)F)c5[nH]ncc45)c(-c4ccncc4)nn13)C2 CHEMBL571744 IC50 4.4 nM
CSc1cccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)c1 CHEMBL386051 Kd 4.4 nM
CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]c(-c4ccc(F)cc4)nc3c2)c1F CHEMBL2436920 IC50 4.4 nM
Nc1nccc(-c2sc(C3CCN(C4CC4)CC3)nc2-c2cccc(NS(=O)(=O)c3cc(F)ccc3F)c2F)n1 CHEMBL5183233 IC50 4.4 nM
Cc1ncc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1c[nH]c(=O)c(N2CCOCC2)n1 CHEMBL3960378 IC50 4.451 nM
COc1n[nH]c2ncc(NC(=O)c3c(F)ccc(NS(=O)(=O)CC(C)C)c3F)cc12 CHEMBL1822090 IC50 4.5 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL388978 IC50 4.5 nM
Nc1nccc(-c2sc(C3CCCNC3)nc2-c2cccc(NS(=O)(=O)c3cc(F)ccc3F)c2F)n1 CHEMBL5190223 IC50 4.5 nM
O=S1(=O)NCCN1CCNc1nccc(-c2c(-c3cccc(O)c3)nc3sccn23)n1 CHEMBL5076688 IC50 4.56 nM
c1ccc(-n2cc(-c3ccc4c(c3)Cc3c[nH]nc3-4)c(-c3ccncc3)n2)cc1 CHEMBL1780174 IC50 4.6 nM
CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3cc(-c4ccccc4)nn3c2)c1F CHEMBL2030242 IC50 4.6 nM
CN1CCN(Cc2cc(NC(=O)Nc3ccc(Oc4ccnc(NC(=O)C5CC5)c4)cc3)cc(C(F)(F)F)c2)CC1 CHEMBL3931682 IC50 4.6 nM
Cc1ccc(NC(=O)c2ccnc(C(F)F)c2)cc1-c1cc(N2CCOCC2)c(=O)n(C)n1 CHEMBL3947882 IC50 4.735 nM
CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]cc(OC)c3c2)c1F CHEMBL4292292 pIC50 4.786 nM
CC(C)(CN)c1nc(-c2ccc(Cl)c(O)c2)c(-c2ccncc2)[nH]1 CHEMBL200889 Kd 4.8 nM
CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]nc(OC)c3c2)c1F CHEMBL1822067 IC50 4.8 nM
CC(F)(F)c1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)c(F)c2)c1 CHEMBL3893548 IC50 4.8 nM
O=C(Nc1ccc(Cl)c(C(F)(F)F)c1)c1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1 CHEMBL3354392 IC50 4.82 nM
Cc1ncc(NC(=O)c2cc(C(F)(F)F)cc(S(C)(=O)=O)c2)cc1-c1ccnc(N2CCOCC2)c1 CHEMBL3891700 IC50 4.83 nM
CC(C)(CN)c1nc(-c2ccc3c(c2)CC/C3=N\O)c(-c2ccncc2)[nH]1 CHEMBL478823 Kd 4.9 nM
CS(=O)(=O)N1C2CCC1CC(c1ccnc3c(-c4cccc5[nH]ncc45)c(-c4ccncc4)nn13)C2 CHEMBL570453 IC50 4.9 nM
O[C@@H]1CNCC[C@H]1n1cc(-c2ccc3c(c2)Cc2c[nH]nc2-3)c(-c2ccncc2)n1 CHEMBL1780175 IC50 4.9 nM
O/N=C/c1ccc(-c2[nH]c(-c3ccccc3)nc2-c2ccncc2)cc1 CHEMBL200783 Kd 5.0 nM
CC(=O)Nc1cc(CNc2ccccc2C(=O)Nc2ccc3c(c2)OC(F)(F)O3)ccn1 CHEMBL248256 IC50 5.0 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1NC(=O)c1cnc2ccccc2c1 CHEMBL480918 IC50 5.0 nM
O=C(Nc1cccc(Oc2cccc3[nH]c(=O)[nH]c23)c1)c1cccc(SC(F)(F)F)c1 CHEMBL605328 IC50 5.0 nM
O=C(Nc1ccc(Oc2ccnc3[nH]c(=O)c(=O)[nH]c23)cc1F)Nc1cc(C(F)(F)F)ccc1F CHEMBL1213691 IC50 5.0 nM
Nc1nc2c(Oc3ccc(NC(=O)Nc4cc(C(F)(F)F)ccc4F)c4ccccc34)ccnc2[nH]c1=O CHEMBL1214129 IC50 5.0 nM
CSc1cc(Oc2ccnc3[nH]c(=O)cnc23)ccc1NC(=O)Nc1cc(C(C)(C)C)nn1-c1ccc(C)cc1 CHEMBL1214056 IC50 5.0 nM
Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)c(C)nc34)c3ccccc23)cc1 CHEMBL1214135 IC50 5.0 nM
CN(C)/C=C/NC(=O)c1oc2cnccc2c1Nc1ccc2c(O)cccc2c1 CHEMBL1667909 IC50 5.0 nM
CN(C)C(=O)c1oc2cnccc2c1Nc1ccc2c(c1)CC/C2=N\O CHEMBL1668916 IC50 5.0 nM
NCc1cc(NC(=O)[C@H]2CCc3ccc(Oc4ccnc(NC(=O)C5CC5)c4)cc3C2)cc(C(F)(F)F)c1 CHEMBL1688869 IC50 5.0 nM
CC(C)NCc1cc(NC(=O)C2CCc3ccc(Oc4ccnc(NC(=O)C5CC5)c4)cc3C2)cc(C(F)(F)F)c1 CHEMBL1688872 IC50 5.0 nM
c1cc(-c2nn(C3CC4COCC(C3)N4)cc2-c2ccc3c(c2)Cc2c[nH]nc2-3)ccn1 CHEMBL1780176 IC50 5.0 nM
CCc1ccc(Nc2nc3cc(Oc4ccnc(C(=O)NC)c4)ccc3o2)cc1 CHEMBL1778394 IC50 5.0 nM
O=C(c1ccc(-c2ccc3c(c2)CCNC3)s1)N1N=C(c2cccnc2)CC1c1ccccc1O CHEMBL1779293 IC50 5.0 nM
NCc1ccc(-c2ccc(C(=O)N3N=C(c4cccnc4)CC3c3ccccc3O)s2)cc1 CHEMBL1779291 IC50 5.0 nM
O=C(c1ccc(-c2ccc(CO)cc2)s1)N1N=C(c2cccnc2)CC1c1ccccc1O CHEMBL1779287 IC50 5.0 nM
O=C(c1ccc(-c2ccccn2)s1)N1N=C(c2cccnc2)CC1c1c(O)cccc1F CHEMBL1779297 IC50 5.0 nM
CN1CCc2ccc(Nc3nccc(-c4c(-c5cccc(NC(=O)Nc6c(F)cccc6F)c5)nc5ccccn45)n3)cc2C1 CHEMBL1807706 IC50 5.0 nM
CC(C)(CO)Nc1nc(-c2cccc(O)c2F)c2c(N)c(C(N)=O)sc2n1 CHEMBL1934648 IC50 5.0 nM
NC(=O)c1sc2nc(NC3CC3)nc(-c3ccc(Cl)c(O)c3)c2c1N CHEMBL1934514 IC50 5.0 nM
C[C@@H](NC1=CC(=O)CC1)c1ccc(Nc2ncc3cc(-c4ccncc4)ccc3n2)cc1 CHEMBL2335904 IC50 5.0 nM
CNS(=O)(=O)c1cccc(Nc2ncnc3[nH]cc(Br)c23)c1 CHEMBL3612666 IC50 5.0 nM
CC(C)(C)CS(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F CHEMBL3799342 IC50 5.0 nM
O=S(=O)(Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F)C1CCOC1 CHEMBL3798235 IC50 5.0 nM
CCCS(=O)(=O)Nc1cc(F)cc(-c2[nH]c(C3CC3)nc2-c2ccnc(NC(C)C)n2)c1Cl CHEMBL3651651 IC50 5.0 nM
CC(C)(C)c1nc(-c2ccnc(N)n2)c(-c2cc(F)cc(NS(C)(=O)=O)c2Cl)[nH]1 CHEMBL3651666 IC50 5.0 nM
COC(=O)N[C@@H](C)CNc1nccc(-c2nc(C3CC3)[nH]c2-c2c(F)ccc(NS(C)(=O)=O)c2Cl)n1 CHEMBL3651688 IC50 5.0 nM
CCCNc1nccc(-c2nc(C3CC3)[nH]c2-c2cc(F)cc(NS(C)(=O)=O)c2Cl)n1 CHEMBL3651646 IC50 5.0 nM
CC(C)CNc1nccc(-c2nc(C3CC3)[nH]c2-c2cc(F)cc(NS(C)(=O)=O)c2Cl)n1 CHEMBL3651648 IC50 5.0 nM
Cc1ccc(C(=O)Nc2cc(N3CCCN(C)CC3)cc(C(F)(F)F)c2)cc1Nc1ncnc2ccc(N3CCOCC3)nc12 CHEMBL3659915 IC50 5.0 nM
Cc1ccc(NC(=O)c2cccc(C(C)(C)C#N)c2)cc1Nc1ncnc2ccc(N[C@H]3CCOC3)nc12 CHEMBL3659967 IC50 5.0 nM
Cc1ccc(C(=O)Nc2ccc(C(F)(F)F)cc2)cc1Nc1ncnc2c(N)nc(N3CCN(C)CC3)nc12 CHEMBL3689904 IC50 5.0 nM
Cc1ccc(C(=O)Nc2cc(C(C)(C)C)n[nH]2)cc1Nc1ncnc2c(N)nc(N3CCN(C4CCCC4)CC3)nc12 CHEMBL3689938 IC50 5.0 nM
COCCN1CCN(c2nc(N)c3ncnc(Nc4cc(C(=O)Nc5cc(C(C)(C)C)n[nH]5)ccc4C)c3n2)CC1 CHEMBL3689940 IC50 5.0 nM
COc1cc(NC(=O)c2ccc(C)c(Nc3ncnc4c(N)nc(N5CCN(C)CC5)nc34)c2)cc(C(F)(F)F)c1 CHEMBL3694011 IC50 5.0 nM
COc1ccc(NC(=O)c2ccc(Cl)c(Nc3ncnc4cnc(NCCN5CCOCC5)nc34)c2)cc1C(F)(F)F CHEMBL3694078 IC50 5.0 nM
COc1ccc(C(=O)Nc2ccc(OC)c(C(F)(F)F)c2)cc1Nc1ncnc2cnc(NCCCN3CCOCC3)nc12 CHEMBL3694087 IC50 5.0 nM
COc1ccc(NC(=O)c2ccc(F)c(Nc3ncnc4cnc(N5CCCCC5)nc34)c2)cc1C(F)(F)F CHEMBL3694098 IC50 5.0 nM
COc1ccc(NC(=O)c2ccc(F)c(Nc3ncnc4cnc(N5CCCC5)nc34)c2)cc1C(F)(F)F CHEMBL3694101 IC50 5.0 nM
COc1ccc(NC(=O)c2ccc(C(F)(F)F)c(Nc3ncnc4cnc(N5CCOCC5)nc34)c2)cc1C(F)(F)F CHEMBL3694113 IC50 5.0 nM
COCCN(C)c1ncc2ncnc(Nc3cc(C(=O)Nc4cc(C(C)(C)C)on4)ccc3Cl)c2n1 CHEMBL3694130 IC50 5.0 nM
CC(C)(C)c1cc(NC(=O)c2ccc(F)c(Nc3ncnc4cnc(N5CCCCC5)nc34)c2)no1 CHEMBL3694151 IC50 5.0 nM
CC(C)(C)c1cc(NC(=O)c2ccc(F)c(Nc3ncnc4cnc(N5CCCC5)nc34)c2)no1 CHEMBL3694153 IC50 5.0 nM
Cc1ccc(C(=O)Nc2cc(CN3CCCC3)cc(C(F)(F)F)c2)cc1Nc1ncnc2cnc(N3CCSCC3)nc12 CHEMBL3694161 IC50 5.0 nM
Cc1ccc(C(=O)Nc2ccc(N(C)CCN(C)C)c(C(F)(F)F)c2)cc1Nc1ncnc2cnc(NCCc3ccccc3)nc12 CHEMBL3694202 IC50 5.0 nM
Cc1ccc(C(=O)Nc2cc(N(C)CCN(C)C)cc(C(F)(F)F)c2)cc1Nc1ncnc2cnc(N3CCSCC3)nc12 CHEMBL3694221 IC50 5.0 nM
Cc1ccc(C(=O)Nc2cc(N(C)CCN(C)C)cc(C(F)(F)F)c2)cc1Nc1ncnc2cnc(N3CCCCC3)nc12 CHEMBL3694229 IC50 5.0 nM
Cc1ccc(C(=O)Nc2ccc(Cl)c(C(F)(F)F)c2)cc1Nc1ncnc2cnc(N3CCCN(C)CC3)nc12 CHEMBL3697766 IC50 5.0 nM
Cc1ccc(C(=O)Nc2cccc(N(C)C)c2)cc1Nc1ncnc2cnc(N3CCN(C)CC3)nc12 CHEMBL3697774 IC50 5.0 nM
Cc1ccc(C(=O)Nc2ccc(C#N)c(C(F)(F)F)c2)cc1Nc1ncnc2cnc(N(C)CCN(C)C)nc12 CHEMBL3697826 IC50 5.0 nM
COc1ccc(C(F)(F)F)cc1NC(=O)c1ccc(C)c(Nc2ncnc3cnc(N4CCN(C)CC4)nc23)c1 CHEMBL3697844 IC50 5.0 nM
Cc1cc(C(=O)Nc2cc(C(C)(C)C)nn2C)cc(Nc2ncnc3cnc(N4CCOCC4)nc23)c1C CHEMBL3697913 IC50 5.0 nM
CCN1CCN(c2ncc3ncnc(Nc4cc(C(=O)Nc5ccc(OC)c(C(F)(F)F)c5)ccc4F)c3n2)CC1 CHEMBL3641032 IC50 5.0 nM
Cc1ccc(C(=O)Nc2cc(C(C)(C)C)on2)cc1Nc1ncnc2cnc(N3CC[C@H](F)C3)nc12 CHEMBL3641039 IC50 5.0 nM
COCCN1CCN(c2ncc3ncnc(Nc4cc(C(=O)Nc5cc(C(C)(C)C)ccc5OC)ccc4C)c3n2)CC1 CHEMBL3641049 IC50 5.0 nM
Cc1ccc(C(=O)Nc2cc(C(C)(C)C)on2)cc1Nc1ncnc2cnc(N3CCN(C4CC4)CC3)nc12 CHEMBL3641109 IC50 5.0 nM
Cc1ccc(C(=O)Nc2cc(N3CCN(C)CC3)c(F)c(C(F)(F)F)c2)cc1Nc1ncnc2cnc(N3CCN(CC4CCN(C)CC4)CC3)nc12 CHEMBL3641124 IC50 5.0 nM
COc1c(CNC(C)C)cc(C(F)(F)F)cc1NC(=O)c1ccc(C)c(Nc2ncnc3cnc(N4CCOCC4)nc23)c1 CHEMBL3641155 IC50 5.0 nM
Cc1ccc(C(=O)Nc2ccnc(C(C)(C)C)c2)cc1Nc1ncnc2cnc(N(C)C3CC(N4CCN(C)CC4)C3)nc12 CHEMBL3641201 IC50 5.0 nM
Cc1ccc(NC(=O)c2cccc(C(C)(C)C#N)c2)cc1Nc1ncnc2cnc(N(C)C3CCOCC3)nc12 CHEMBL3641232 IC50 5.0 nM
Cc1ccc(C(=O)Nc2cc(C(C)(C)C)n[nH]2)cc1Nc1ncnc2cncnc12 CHEMBL3643297 IC50 5.0 nM
CC(=O)c1ccc(Nc2nccc3c(NC(=O)c4csc5c(N)ncnc45)c(C)ccc23)cc1 CHEMBL3944137 IC50 5.0 nM
Cc1ccc(C(=O)Nc2cc(C(F)(F)F)ccn2)cc1-n1cc(-c2cncc(N3CCNCC3)c2)nn1 CHEMBL3902578 IC50 5.0 nM
Cc1ccc(NC(=O)c2cc(C(C)(C)C)on2)cc1-n1cc(-c2cncc(N3CCN(C)CC3)c2)nn1 CHEMBL3913409 IC50 5.0 nM
C=CCN1CCN(c2cncc(-c3cn(-c4cc(NC(=O)c5ccc(C(C)(C)C)o5)ccc4C)nn3)c2)CC1 CHEMBL3951752 IC50 5.0 nM
Cc1ccc(NC(=O)c2ccc(C(C)(C)C)o2)cc1-n1cc(-c2cncc(N3CCN(CC(C)C)CC3)c2)nn1 CHEMBL3915027 IC50 5.0 nM
CC(=O)Nc1cn2cc(-c3cc(NC(=O)c4ccc(CN5CCN(C)CC5)c(C(F)(F)F)c4)ccc3C)ccc2n1 CHEMBL4205266 IC50 5.0 nM
CSc1cc(Oc2ccnc3[nH]c(=O)cnc23)ccc1NC(=O)Nc1cc(C(C)(C)C)nn1-c1ccccc1 CHEMBL4204895 IC50 5.0 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)cnc34)cc2F)n(-c2ccccc2)n1 CHEMBL4216588 IC50 5.0 nM
O=C(Nc1cccc(C(F)(F)F)c1)c1ccc(C(F)F)c(-c2ccnc(N3CCOCC3)c2)c1 CHEMBL3891340 IC50 5.035 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)cc2[nH]c(=O)oc12 CHEMBL3976967 IC50 5.048 nM
COc1n[nH]c2ncc(NC(=O)c3cccc(NC(=O)c4cccc(C(C)(C)C#N)c4)c3F)cc12 CHEMBL2153633 IC50 5.1 nM
Nc1ncc(-c2cccnc2)c2scc(-c3cccc(NC(=O)c4cccc(C(F)(F)F)c4)c3)c12 CHEMBL2315069 IC50 5.1 nM
O=C(Nc1cc(F)cc(Oc2ccnc(NC(=O)C3CC3)c2)c1)Nc1ccc(Cl)c(C(F)(F)F)c1 CHEMBL3946238 IC50 5.1 nM
CS(=O)(=O)c1cc(NC(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)cc2)cc(C(F)(F)F)c1 CHEMBL3928460 IC50 5.1 nM
CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(-c4ccc(CNC(=O)CCCCNc5ccc6c(c5)C(=O)N(C5CCC(=O)N(C)C5=O)C6=O)cc4)cc23)c1F CHEMBL4449322 Kd 5.1 nM
CC(C)NC(=O)c1oc2cnccc2c1Nc1ccc2c(c1)CN/C2=N\O CHEMBL1667896 IC50 5.2 nM
Cc1cc(C(=O)Nc2c(Cl)ccc(NS(=O)(=O)c3cc(F)ccc3F)c2F)c2ncnc(NCCN)c2c1 CHEMBL4740654 Ki 5.2 nM
O=S1(=O)NCCCN1CCNc1nccc(-c2c(-c3cccc(O)c3)nc3sccn23)n1 CHEMBL5079502 IC50 5.21 nM
NCc1ccc(-c2nc(-c3ccc(Cl)c(O)c3)c(-c3ccncc3)[nH]2)cc1 CHEMBL200320 Kd 5.3 nM
CCn1cc(-c2ccnc3[nH]ccc23)c(-c2cccc(NC(=O)Nc3ccccc3Cl)c2)n1 CHEMBL525896 IC50 5.3 nM
CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]nc(OCC(F)(F)F)c3c2)c1F CHEMBL1822252 IC50 5.3 nM
CN1CCC(Oc2cc(NC(=O)Nc3ccc(Oc4ccnc(NC(=O)C5CC5)c4)c(F)c3)cc(C(F)(F)F)c2)C1 CHEMBL3986500 IC50 5.3 nM
CCn1cc(-c2ccnc3[nH]ccc23)c(-c2cccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)c2)n1 CHEMBL456983 IC50 5.4 nM
CNc1ncc2cc(-c3c(C)ccc4c(Nc5ccc(Cl)cc5)nccc34)ccc2n1 CHEMBL576787 IC50 5.4 nM
O=C1CCc2c(Oc3ccc4c(c3)C3C(O4)C3c3nc4cc(Cl)c(F)cc4[nH]3)ccnc2N1 CHEMBL3975784 IC50 5.4 nM
CN1CCC(c2cc(NC(=O)Nc3ccc(Oc4ccnc(NC(=O)C5CC5)c4)cc3)cc(C(F)(F)F)c2)CC1 CHEMBL3968087 IC50 5.5 nM
CC1(C)OC(c2ccnc(N)n2)=C(c2cc(Cl)cc(NS(=O)(=O)c3c(F)cccc3F)c2F)C1=O CHEMBL3959779 IC50 5.5 nM
O=C(c1cc(-c2ccco2)on1)N1N=C(c2cccnc2)CC1c1ccccc1O CHEMBL1782337 IC50 5.6 nM
CCCS(=O)(=O)Nc1ccc(F)c(NC(=O)Nc2ncnc3[nH]ncc23)c1F CHEMBL2047871 IC50 5.6 nM
N#CC1(c2cccc(C(=O)Nc3cc(Oc4ccc5nc(NC(=O)C6CC6)sc5n4)ccc3F)c2Cl)CC1 CHEMBL2063743 IC50 5.6 nM
O=S(=O)(NCCCNc1nccc(-c2[nH]c(-c3ccccc3)nc2-c2ccc(F)c(O)c2)n1)c1ccccc1 CHEMBL4758203 IC50 5.62 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(C(C)C)nc(N2CCOCC2)n1 CHEMBL3971265 IC50 5.678 nM
Nc1nccc(-c2[nH]c(-c3ccccc3)nc2-c2ccc(Cl)c(O)c2)n1 CHEMBL200258 Kd 5.7 nM
Clc1cc(Nc2c(-c3ncccn3)oc3cnccc23)c2cn[nH]c2c1 CHEMBL1667917 IC50 5.7 nM
Cc1ccc(NC(=O)c2cc(C(F)(F)F)cnn2)cc1-c1ccc2c(c1)OC1(CCOCC1)CC(=O)N2 CHEMBL5078176 IC50 5.7 nM
COCCOCC(=O)Nc1nc2ccc(Oc3ccc(F)c(NC(=O)Cc4cccc(C(F)(F)F)c4)c3)c(C#N)c2s1 CHEMBL4237480 IC50 5.75 nM
Cc1ncc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)c(=O)n(C2CCOCC2)c1 CHEMBL3917231 IC50 5.77 nM
CCn1cc(C(=O)Nc2ccc(C)c(-c3ccnc(N4CCOCC4)c3)c2)cc(C(F)(F)F)c1=O CHEMBL3903630 IC50 5.788 nM
CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]nc(C(F)(F)F)c3c2)c1F CHEMBL1822245 IC50 5.8 nM
O=C1CCc2c(Oc3ccc4c(c3)C3C(O4)C3c3nc4cc(F)c(F)cc4[nH]3)ccnc2N1 CHEMBL3935563 IC50 5.9 nM
Nc1nccc(-c2sc(C3CNCCN3)nc2-c2cccc(NS(=O)(=O)c3cc(F)ccc3F)c2F)n1 CHEMBL5192974 IC50 5.9 nM
Oc1cc(-c2[nH]c(-c3cccnc3)nc2-c2ccncc2)ccc1Cl CHEMBL381250 IC50 6.0 nM
O/N=C/c1ccc(-c2[nH]c(-c3ccccc3)nc2-c2ccncc2)cc1Cl CHEMBL200412 Kd 6.0 nM
O=C(Nc1cccc(C(F)(F)F)c1)Nc1ccc(Oc2ccnc3[nH]c(=O)[nH]c23)c2ccccc12 CHEMBL523753 IC50 6.0 nM
O=C(Nc1ccc(Cl)c(C(F)(F)F)c1)Nc1ccc(Oc2ccnc3[nH]c(=O)cnc23)cc1F CHEMBL1213824 IC50 6.0 nM
CSc1cc(Oc2ccnc3[nH]c(=O)c(C)nc23)ccc1NC(=O)Nc1cc(C(C)(C)C)nn1-c1ccc(C)cc1 CHEMBL1214057 IC50 6.0 nM
NCc1cc(NC(=O)[C@@H]2CCc3ccc(Oc4ccnc(NC(=O)C5CC5)c4)cc3C2)cc(C(F)(F)F)c1 CHEMBL1688870 IC50 6.0 nM
CNC(=O)c1cc(Oc2ccc3oc(Nc4ccc(C(C)C)cc4)nc3c2)ccn1 CHEMBL1778395 IC50 6.0 nM
CNC(=O)c1cc(Oc2ccc3oc(Nc4cccc(C(C)(C)C)c4)nc3c2)ccn1 CHEMBL1778291 IC50 6.0 nM
O=C(c1ccc(-c2cccc(CN3CCCC3)c2)s1)N1N=C(c2cccnc2)CC1c1ccccc1O CHEMBL1779290 IC50 6.0 nM
NCc1cccc(-c2ccc(C(=O)N3N=C(c4cccnc4)CC3c3ccccc3O)s2)c1 CHEMBL1779288 IC50 6.0 nM
O=C(Nc1cccc(Nc2cc3c(cc2Cl)C(=O)NC3=O)c1)c1cccc(OC(F)(F)F)c1 CHEMBL1922591 IC50 6.0 nM
CCCS(=O)(=O)Nc1ccc(F)c(-c2cc3cnc(NCCO)nc3n(C)c2=O)c1F CHEMBL2023497 IC50 6.0 nM
CCN1CCN(CC(=O)Nc2cc(Oc3ccc4c(c3)nc(Nc3cc(C(F)(F)F)ccc3F)n4C)ccn2)CC1 CHEMBL3335387 IC50 6.0 nM
CC(C)N1CCN(CC(=O)Nc2cc(Oc3ccc4c(c3)nc(Nc3cc(C(F)(F)F)ccc3F)n4C)ccn2)CC1 CHEMBL3335386 IC50 6.0 nM
CNS(=O)(=O)c1cccc(Nc2ncnc3[nH]cc(-c4ccc(CN)cc4)c23)c1 CHEMBL3613181 IC50 6.0 nM
CNS(=O)(=O)c1cccc(Nc2ncnc3[nH]c(-c4ccccc4C)cc23)c1 CHEMBL3613185 IC50 6.0 nM
CNS(=O)(=O)c1cccc(Nc2ncnc3[nH]c(-c4cccc(C(F)(F)F)c4)cc23)c1 CHEMBL3613188 IC50 6.0 nM
CNS(=O)(=O)c1ccc(N(C)C)c(Nc2ncnc3[nH]ccc23)c1 CHEMBL3613195 IC50 6.0 nM
CC(C)CS(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F CHEMBL3799488 IC50 6.0 nM
O=C(NOC[C@H](O)CO)c1ccc(F)c(F)c1Nc1ccc(I)cc1F CHEMBL507361 IC50 6.0 nM
COC(=O)N[C@@H](C)CNc1nccc(-c2cn(C(C)C)nc2-c2cc(Cl)cc(NS(C)(=O)=O)c2Cl)n1 CHEMBL3967576 IC50 6.0 nM
Cc1ccc(C(=O)Nc2cc(C(C)(C)C)n[nH]2)cc1Nc1ncnc2c(N)nc(N3CCN(CC4CCCO4)CC3)nc12 CHEMBL3689937 IC50 6.0 nM
COc1ccc(NC(=O)c2ccc(Cl)c(Nc3ncnc4cnc(N5CCCCC5)nc34)c2)cc1C(F)(F)F CHEMBL3694073 IC50 6.0 nM
COc1ccc(C(=O)Nc2ccc(OC)c(C(F)(F)F)c2)cc1Nc1ncnc2cnc(N3CCN(C)CC3)nc12 CHEMBL3694085 IC50 6.0 nM
CN(C)c1ncc2ncnc(Nc3cc(C(=O)Nc4cc(C(C)(C)C)on4)ccc3Cl)c2n1 CHEMBL3694132 IC50 6.0 nM
COCCN(C)c1ncc2ncnc(Nc3cc(C(=O)Nc4cc(C(C)(C)C)on4)ccc3OC)c2n1 CHEMBL3694143 IC50 6.0 nM
CNc1ncc2ncnc(Nc3cc(C(=O)Nc4cc(C(C)(C)C)on4)ccc3F)c2n1 CHEMBL3694157 IC50 6.0 nM
Cc1ccc(C(=O)Nc2cc(N(C)CCN(C)C)cc(C(F)(F)F)c2)cc1Nc1ncnc2cnc(N3CC[S+]([O-])CC3)nc12 CHEMBL3694223 IC50 6.0 nM
COc1ccc(C(C)(C)C)cc1NC(=O)c1ccc(C)c(Nc2ncnc3cnc(N4CCN(C)CC4)nc23)c1 CHEMBL3697776 IC50 6.0 nM
Cc1ccc(C(=O)Nc2cccc(C(C)(C)C)c2)cc1Nc1ncnc2cnc(N(C)CCN(C)C)nc12 CHEMBL3697785 IC50 6.0 nM
Cc1ccc(C(=O)Nc2cccc(C(C)(C)C#N)c2)cc1Nc1ncnc2cnc(N3CCCC3)nc12 CHEMBL3697822 IC50 6.0 nM
Cc1ccc(C(=O)Nc2cc(C(F)(F)F)ccn2)cc1Nc1ncnc2cnc(N(C)CCN(C)C)nc12 CHEMBL3697824 IC50 6.0 nM
Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1ncnc2cnc(N3CCCCC3)nc12 CHEMBL3697874 IC50 6.0 nM
Cc1ccc(C(=O)Nc2cc(C(C)(C)C)on2)cc1Nc1ncnc2cnc(N3CC(F)(F)C3)nc12 CHEMBL3697908 IC50 6.0 nM
CN(C)C1CCN(c2ncc3ncnc(Nc4cc(Cl)cc(C(=O)Nc5cc(C(C)(C)C)nn5C)c4)c3n2)C1 CHEMBL3697920 IC50 6.0 nM
COc1ccc(NC(=O)c2ccc(F)c(Nc3ncnc4cnc(N5CCN(CC6CC6)CC5)nc34)c2)cc1C(F)(F)F CHEMBL3641031 IC50 6.0 nM
CCN1CCN(c2cc(NC(=O)c3ccc(C)c(Nc4ncnc5cnc(N6CCN(CCOC)CC6)nc45)c3)cc(C(F)(F)F)c2)CC1 CHEMBL3641051 IC50 6.0 nM
COc1ccc(NC(=O)c2ccc(C)c(Nc3ncnc4cnc(N5CCN(CC6CCOC6)CC5)nc34)c2)cc1C(F)(F)F CHEMBL3641059 IC50 6.0 nM
Cc1ccc(C(=O)Nc2cc(N(C)CCN(C)C)cc(C(F)(F)F)c2)cc1Nc1ncnc2cnc(N3CC[C@H](F)C3)nc12 CHEMBL3641064 IC50 6.0 nM
Cc1ccc(C(=O)Nc2cc(C(C)(C)C)n[nH]2)cc1Nc1ncnc2cnc(N3CCCN(C)CC3)nc12 CHEMBL3641072 IC50 6.0 nM
Cc1ccc(C(=O)Nc2cc(C(C)(C)C)on2)cc1Nc1ncnc2cnc(N3CCC(N4C[C@@H](C)O[C@@H](C)C4)CC3)nc12 CHEMBL3641104 IC50 6.0 nM
COCCN1CCN(c2ncc3ncnc(Nc4cc(C(=O)Nc5cc(C(F)(F)F)ccc5Cl)ccc4C)c3n2)CC1 CHEMBL3641148 IC50 6.0 nM
CC1=Nc2ccc(NC(=O)c3ccc(C)c(Nc4ncnc5cnc(N6CCC(CN7CCCC7)CC6)nc45)c3)cc2C1(C)C CHEMBL3641205 IC50 6.0 nM
Cc1cn(-c2ncc3ncnc(Nc4cc(C(=O)Nc5cc(C(C)(C)C)n[nH]5)ccc4C)c3n2)cn1 CHEMBL3641209 IC50 6.0 nM
O=C1CCc2c(Oc3ccc4c(c3)C3C(O4)C3c3nc(C(F)(F)F)c[nH]3)ccnc2N1 CHEMBL3932596 IC50 6.0 nM
Cc1ccc(C(=O)Nc2cc(C(C)(C)C)on2)cc1-n1cc(-c2cncc(NC3CCOC3)c2)nn1 CHEMBL3936474 IC50 6.0 nM
CCN1CCN(c2cncc(-c3cn(-c4cc(C(=O)Nc5cc(C(C)(C)C)on5)ccc4C)nn3)c2)CC1 CHEMBL3958823 IC50 6.0 nM
Cc1ccc(C(=O)Nc2cc(C(F)(F)F)ccn2)cc1-n1cc(-c2cncc(NC3CCN(C)C3)c2)nn1 CHEMBL3977418 IC50 6.0 nM
Cc1ccc(C(=O)Nc2cc(C(F)(F)F)ccn2)cc1-n1cc(-c2cncc(N3C[C@@H]4C[C@H]3CN4C)c2)nn1 CHEMBL3951820 IC50 6.0 nM
Cc1ccc(C(=O)Nc2cc(C(C)(C)C)on2)cc1-n1cc(-c2cncc(N3CCC(N4CCN(C)CC4)C3)c2)nn1 CHEMBL3896026 IC50 6.0 nM
Cc1ccc(NC(=O)c2ccc(C(C)(C)C)s2)cc1-n1cc(-c2cncc(N3CCN(C)CC3)c2)nn1 CHEMBL3937760 IC50 6.0 nM
CC(=O)Nc1cn2cc(-c3cc(NC(=O)c4cccc(C(F)(F)F)n4)ccc3C)ccc2n1 CHEMBL4209163 IC50 6.0 nM
COC(=O)Nc1nc2cc(C3(O)c4ccccc4C(=O)N3c3cc(Cl)ccc3C)ccc2[nH]1 CHEMBL3545027 IC50 6.0 nM
Nc1nccc(-c2sc(C3COCCN3)nc2-c2cccc(NS(=O)(=O)c3cc(F)ccc3F)c2F)n1 CHEMBL5186595 IC50 6.0 nM
COC(=O)N[C@@H](C)CNc1nccc(-c2cn(C(C)C)nc2-c2ccc(F)c(NS(C)(=O)=O)c2F)n1 CHEMBL3890179 IC50 6.1 nM
O=C(Nc1cccc(C(F)(F)F)c1)c1ccc(CO)c(-c2ccnc(N3CCOCC3)c2)c1 CHEMBL3928316 IC50 6.113 nM
CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]cc(C(F)(F)F)c3c2)c1F CHEMBL1822250 IC50 6.2 nM
Cc1cc(Oc2ccnc(NC(=O)C3CC3)c2)ncc1NC(=O)Nc1cc(C(C)(F)F)ccc1F CHEMBL3965770 IC50 6.2 nM
Cc1ccc(C(=O)Nc2ccc(Cl)c(C(F)(F)F)c2)cc1NC(=O)C(C)(C)c1ncnc2[nH]ccc12 CHEMBL4457131 IC50 6.2 nM
Nc1cccc(-c2nc3sccn3c2-c2ccnc(NCCCCNS(=O)(=O)c3ccc(F)cc3)n2)c1 CHEMBL4753878 IC50 6.21 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc2[nH]cnc2c(N2CCOC[C@H]2C)n1 CHEMBL4115500 IC50 6.261 nM
Cc1ccc(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1-c1cc(N2CCOCC2)ncn1 CHEMBL3985343 IC50 6.271 nM
COCCN1CCC(c2nc(-c3ccc4c(c3)CC/C4=N\O)c(-c3ccncc3)[nH]2)CC1 CHEMBL477774 Kd 6.3 nM
CCCS(=O)(=O)Nc1ccc(Cl)c(C(=O)Nc2cnc3[nH]ncc3c2)c1F CHEMBL1945165 IC50 6.3 nM
CNS(=O)(=O)c1ccc(N(C)C)c(Nc2ncnc3[nH]c(Br)cc23)c1 CHEMBL3613306 IC50 6.3 nM
O=C(Nc1cccc(C(F)(F)F)c1)Nc1ccc(Oc2ccnc(NC(=O)C3CC3)c2)c(F)c1 CHEMBL3978551 IC50 6.3 nM
CCCS(=O)(=O)Nc1ccc(Cl)c(C(=O)Nc2cnc3[nH]ccc3c2)c1F CHEMBL1822079 IC50 6.3 nM
NCCCc1nc(-c2cccc(NS(=O)(=O)c3cc(F)ccc3F)c2F)c(-c2ccnc(N)n2)s1 CHEMBL5195570 IC50 6.3 nM
CC1(C)CN(CCNc2nccc(-c3c(-c4cccc(O)c4)nc4sccn34)n2)S(=O)(=O)N1 CHEMBL5088891 IC50 6.35 nM
CN(C)C(=O)N1C2CCC1CC(c1ccnc3c(-c4cccc5[nH]ncc45)c(-c4ccncc4)nn13)C2 CHEMBL584942 IC50 6.4 nM
O=C(Nc1cccc(C(F)(F)F)c1)Nc1ccc(Oc2ccnc(NC(=O)C3CC3)c2)cc1F CHEMBL3972921 IC50 6.4 nM
Cc1nc(-c2cnccn2)sc1C(=O)N1N=C(c2cccnc2)CC1c1ccccc1O CHEMBL1782344 IC50 6.5 nM
COc1cc(-c2nn(C(C)C)cc2-c2ccnc(NC[C@H](C)O)n2)cnc1N CHEMBL2207688 IC50 6.5 nM
COc1n[nH]c2ncc(NC(=O)c3cc(C(=O)Nc4cccc(C(F)(F)F)c4)ccc3C)cc12 CHEMBL2153638 IC50 6.6 nM
CS(=O)(=O)Nc1cc(NC(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)c(F)c2)cc(C(F)(F)F)c1 CHEMBL3943475 IC50 6.6 nM
CCNC(=O)N1C2CCC1CC(c1ccnc3c(-c4cccc5[nH]ncc45)c(-c4ccncc4)nn13)C2 CHEMBL570658 IC50 6.7 nM
COc1cccc(-c2cc(C(=O)N3N=C(c4cccnc4)CC3c3ccccc3O)no2)c1 CHEMBL1782338 IC50 6.7 nM
O=C1CCc2c(Oc3ccc4c(c3)[C@H]3C(c5nc6ccc(C(F)(F)F)cc6[nH]5)[C@H]3O4)ccnc2N1 CHEMBL4111470 IC50 6.7 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(=O)cc(N2CCOCC2)[nH]1 CHEMBL3948871 IC50 6.733 nM
CC(C)(C#N)c1cccc(C(=O)Nc2ccc(F)c(C(=O)Nc3cnc4[nH]ccc4c3)c2F)c1 CHEMBL2153511 IC50 6.8 nM
Cc1cc(Oc2ccnc(NC(=O)C3CC3)c2)ccc1NC(=O)Nc1cccc(C(F)(F)F)c1 CHEMBL3909992 IC50 6.8 nM
O=C(c1cc2c(s1)CCC2)N1N=C(c2cccnc2)CC1c1ccccc1O CHEMBL1782349 IC50 6.9 nM
CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]nc(O[C@@H]4CCOC4)c3c2)c1F CHEMBL1822255 IC50 6.9 nM
Cc1ncc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)c(=O)n(C)n1 CHEMBL3968234 IC50 6.933 nM
Cc1ncc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)cnn1 CHEMBL3921105 IC50 6.966 nM
CCCC1CCCCN1C(=O)c1cc(Oc2ccc3c(c2)nc(Nc2ccc(Br)cc2)n3C)ccn1 CHEMBL486341 IC50 7.0 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1C(=O)Nc1cccnc1 CHEMBL454104 IC50 7.0 nM
Cc1ccc(NC(=O)c2cccc(C(C)(C)C#N)c2)cc1C(=O)Nc1cccnc1 CHEMBL480389 IC50 7.0 nM
O=C(Nc1cc(F)cc(C(F)(F)F)c1)Nc1ccc(Oc2ccnc3[nH]c(=O)[nH]c23)cc1F CHEMBL496612 IC50 7.0 nM
O=C(Nc1cccc(SC(F)(F)F)c1)Nc1ccc(Oc2ccnc3[nH]c(=O)[nH]c23)cc1F CHEMBL522072 IC50 7.0 nM
O=C(Nc1cc(Oc2cccc3[nH]c(=O)[nH]c23)c(F)c(F)c1F)c1cccc(OC(F)(F)F)c1 CHEMBL602123 IC50 7.0 nM
CC(C)(C)c1cccc(C(=O)Nc2cccc(Oc3ccnc4[nH]c(=O)cnc34)c2)c1 CHEMBL1214617 IC50 7.0 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)c(N)nc34)c3ccccc23)n(-c2ccccc2)n1 CHEMBL1214133 IC50 7.0 nM
Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)c(N)nc34)c3ccccc23)cc1 CHEMBL1214136 IC50 7.0 nM
CC(=O)Nc1cc(Oc2ccc3c(c2)C[C@@H](C(=O)Nc2cc(CN)cc(C(F)(F)F)c2)CC3)ccn1 CHEMBL1688867 IC50 7.0 nM
CNC(=O)c1cc(Oc2ccc3sc(Nc4ccc(Br)cc4)nc3c2)ccn1 CHEMBL1778405 IC50 7.0 nM
Cc1nc(-c2ccc(C(=O)N3N=C(c4cccnc4)CC3c3ccccc3O)s2)cs1 CHEMBL1779285 IC50 7.0 nM
O=C(c1ccc(-c2ccccn2)s1)N1N=C(c2cccnc2)CC1c1cc(F)ccc1O CHEMBL1779422 IC50 7.0 nM
NCc1ccccc1-c1ccc(C(=O)N2N=C(c3cccnc3)CC2c2c(O)cccc2F)s1 CHEMBL1779592 IC50 7.0 nM
NCc1ccccc1-c1ccc(C(=O)N2N=C(c3cncc(N)c3)CC2c2ccccc2O)s1 CHEMBL1778672 IC50 7.0 nM
O=C(c1[nH]nc2c1CCC2)N1N=C(c2cccnc2)CC1c1ccccc1O CHEMBL1782347 IC50 7.0 nM
CCCS(=O)(=O)Nc1ccc(F)c(-c2cc3cnc(NCCCO)nc3n(C)c2=O)c1F CHEMBL2023498 IC50 7.0 nM
CC(C)(C)c1nc(-c2cccc(NS(=O)(=O)c3cc(F)ccc3F)c2)c(-c2ccnc(N)n2)s1 CHEMBL2337910 IC50 7.0 nM
Cn1c(Nc2cccc(C(C)(C)C)c2)nc2cc(Oc3ccnc(NC(=O)C4CCNCC4)c3)ccc21 CHEMBL3335382 IC50 7.0 nM
COc1cc2c(cnc3[nH]ncc32)cc1-c1c(F)ccc(NS(=O)(=O)CCCF)c1Cl CHEMBL3752478 IC50 7.0 nM
COc1cc2c(cnc3[nH]nc(C4CC4)c32)cc1-c1c(F)ccc(NS(=O)(=O)CCCF)c1Cl CHEMBL3751896 IC50 7.0 nM
O=S(=O)(Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F)c1ccccc1 CHEMBL3798308 IC50 7.0 nM
CCC(C)S(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F CHEMBL3800227 IC50 7.0 nM
COC(=O)N[C@@H](C)CNc1nccc(-c2cn(C3CCCCO3)nc2-c2cc(Cl)cc(NS(C)(=O)=O)c2F)n1 CHEMBL3967614 IC50 7.0 nM
COC(=O)N[C@@H](C)CNc1nccc(-c2nc(C3CC3)[nH]c2-c2cc(Cl)cc(NS(=O)(=O)c3ccc(C(F)(F)F)cc3)c2F)n1 CHEMBL3651670 IC50 7.0 nM
[C-]#[N+]C(C)(C)c1cccc(NC(=O)c2ccc(C)c(Nc3ncnc4ccc(N5CCOCC5)nc34)c2)c1 CHEMBL3659910 IC50 7.0 nM
Cc1ccc(C(=O)Nc2cc(C(C)(C)C)n[nH]2)cc1Nc1ncnc2ccc(N3CCOCC3)nc12 CHEMBL3659912 IC50 7.0 nM
Cc1ccc(C(=O)Nc2ccc(C(F)(F)F)cc2)cc1Nc1ncnc2c(N)nc(N3CCNCC3)nc12 CHEMBL3689903 IC50 7.0 nM
Cc1ccc(C(=O)Nc2ccc(C#N)c(C(F)(F)F)c2)cc1Nc1ncnc2c(N)nc(N3CCN(C)CC3)nc12 CHEMBL3694028 IC50 7.0 nM
Cc1ccc(C(=O)Nc2cc(C(C)(C)C)nn2C)cc1Nc1ncnc2c(N)nc(N3CCN4CCCC4C3)nc12 CHEMBL3694042 IC50 7.0 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1Nc1ncnc2c(N)nc(N3CCCN(c4ccncc4)CC3)nc12 CHEMBL3694057 IC50 7.0 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1Nc1ncnc2c(N)nc(N3C[C@H](C)NC[C@H]3C)nc12 CHEMBL3694058 IC50 7.0 nM
COc1ccc(NC(=O)c2ccc(Cl)c(Nc3ncnc4cnc(N5CCCCCC5)nc34)c2)cc1C(F)(F)F CHEMBL3694069 IC50 7.0 nM
COc1ccc(NC(=O)c2ccc(Cl)c(Nc3ncnc4cnc(N5CCN(C)CC5)nc34)c2)cc1C(F)(F)F CHEMBL3694072 IC50 7.0 nM
COc1ccc(C(=O)Nc2ccc(OC)c(C(F)(F)F)c2)cc1Nc1ncnc2cnc(N3CCCCC3)nc12 CHEMBL3694086 IC50 7.0 nM
CC(C)(C)c1cc(NC(=O)c2ccc(F)c(Nc3ncnc4cnc(N5CCCCCC5)nc34)c2)no1 CHEMBL3694148 IC50 7.0 nM
Cc1ccc(C(=O)Nc2cc(N(C)CCN(C)C)cc(C(F)(F)F)c2)cc1Nc1ncnc2cnc(N3CCCCCC3)nc12 CHEMBL3694220 IC50 7.0 nM
Cc1ccc(C(=O)Nc2cccc(S(=O)(=O)N(C)C)c2)cc1Nc1ncnc2cnc(N3CC[C@H](F)C3)nc12 CHEMBL3697838 IC50 7.0 nM
Cc1ccc(C(=O)Nc2cccc(S(=O)(=O)N(C)C)c2)cc1Nc1ncnc2cnc(N3CCN(C)CC3)nc12 CHEMBL3697848 IC50 7.0 nM
Cc1ccc(C(=O)Nc2cccc(S(=O)(=O)N(C)C)c2)cc1Nc1ncnc2cnc(N3CCNCC3)nc12 CHEMBL3697888 IC50 7.0 nM
Cn1nc(C(C)(C)C)cc1NC(=O)c1cc(Cl)cc(Nc2ncnc3cnc(N4CCOCC4)nc23)c1 CHEMBL3697917 IC50 7.0 nM
Cc1ccc(C(=O)Nc2cc(C(C)(C)C)nn2C)cc1Nc1ncnc2cnc(N3CCN(CC4CCN(C)CC4)CC3)nc12 CHEMBL3641041 IC50 7.0 nM
COCCN1CCN(c2ncc3ncnc(Nc4cc(C(=O)Nc5cc(C(C)(C)C)n[nH]5)ccc4C)c3n2)CC1 CHEMBL3641052 IC50 7.0 nM
Cc1ccc(C(=O)Nc2cccc(C(C)(C)C#N)c2)cc1Nc1ncnc2cnc(NCc3ccccc3)nc12 CHEMBL3641057 IC50 7.0 nM
COc1ccc(NC(=O)c2ccc(C)c(Nc3ncnc4cnc(N5CCN(C6CC6)CC5)nc34)c2)cc1C(F)(F)F CHEMBL3641060 IC50 7.0 nM
COc1ccc(NC(=O)c2ccc(C)c(Nc3ncnc4cnc(N5CCC(N6CCCCC6)CC5)nc34)c2)cc1C(F)(F)F CHEMBL3641171 IC50 7.0 nM
COc1ccc(NC(=O)c2ccc(C)c(Nc3ncnc4cnc(N5CCC(N6CCCC6)CC5)nc34)c2)cc1C(F)(F)F CHEMBL3641175 IC50 7.0 nM
COCCN1CCN(c2ncc3ncnc(Nc4cc(C(=O)Nc5ccc6c(c5)OC(F)(F)OC6(F)F)ccc4C)c3n2)CC1 CHEMBL3641212 IC50 7.0 nM
CCCS(=O)(=O)Nc1ccc(F)c(-n2cc(-c3cncc(OC)c3)c3nc(N(C)C4CCN(C)CC4)ncc32)c1F CHEMBL3702560 IC50 7.0 nM
Cc1ccc2c(Nc3ccc(Cl)c(CN(C)C)c3)nccc2c1NC(=O)c1csc2c(N)ncnc12 CHEMBL3982491 IC50 7.0 nM
Cc1ccc2c(Nc3cccc(Cl)c3F)nccc2c1NC(=O)c1csc2c(N)ncnc12 CHEMBL3977543 IC50 7.0 nM
O=S(=O)(Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F)c1ccsc1 CHEMBL3982836 IC50 7.0 nM
Cc1ccc(C(=O)Nc2cc(C(C)(C)C)on2)cc1-n1cc(-c2cncc(N(C)CCN(C)C)c2)nn1 CHEMBL3973582 IC50 7.0 nM
Cc1ccc(C(=O)Nc2cc(C(C)(C)C)on2)cc1-n1cc(-c2cncc(N(C)C3CCOCC3)c2)nn1 CHEMBL3921755 IC50 7.0 nM
Cc1ccc(C(=O)Nc2cc(C(C)(C)C)on2)cc1-n1cc(-c2cncc(NCCN(C)C)c2)nn1 CHEMBL3973303 IC50 7.0 nM
Cc1ccc(C(=O)Nc2cc(C(F)(F)F)ccn2)cc1-n1cc(-c2cncc(N(C)C3CCOC3)c2)nn1 CHEMBL3891259 IC50 7.0 nM
Cc1ccc(C(=O)Nc2cc(C(F)(F)F)ccn2)cc1-n1cc(-c2cncc(N3CCC(N(C)C)C3)c2)nn1 CHEMBL3911586 IC50 7.0 nM
Cc1ccc(C(=O)Nc2cc(C(F)(F)F)ccn2)cc1-n1cc(-c2cncc(N3CCN(C)CC3)c2)nn1 CHEMBL3924110 IC50 7.0 nM
Cc1ccc(C(=O)Nc2cc(C(F)(F)F)ccn2)cc1-n1cc(-c2cncc(N3CCCC3)c2)nn1 CHEMBL3906033 IC50 7.0 nM
CCN1CCN(c2cncc(-c3cn(-c4cc(C(=O)Nc5cc(C(F)(F)F)ccn5)ccc4C)nn3)c2)CC1 CHEMBL3938547 IC50 7.0 nM
CCOCCN1CCN(c2cncc(-c3cn(-c4cc(NC(=O)c5ccc(C(C)(C)C)o5)ccc4C)nn3)c2)CC1 CHEMBL3929800 IC50 7.0 nM
COCCCN1CCN(c2cncc(-c3cn(-c4cc(NC(=O)c5ccc(C(C)(C)C)s5)ccc4C)nn3)c2)CC1 CHEMBL3931777 IC50 7.0 nM
N#Cc1ccc(NC(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)c(F)c2)cc1C(F)(F)F CHEMBL3940692 IC50 7.0 nM
Nc1cc(NC(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)c(F)c2)cc(C(F)(F)F)c1 CHEMBL3932357 IC50 7.0 nM
CNS(=O)(=O)Nc1nccc(Cc2c(C)c3ccc(Oc4ncccn4)cc3oc2=O)c1F CHEMBL3264002 Kd apparent 7.0 nM
COc1cc2c(cnc3[nH]nc(C4CC4)c32)cc1-c1c(F)ccc(NS(=O)(=O)CCCF)c1F CHEMBL4294276 IC50 7.0 nM
O=C(Nc1cccc(-n2cc(-c3ccncc3)c(-c3cc(O)cc(Cl)c3)n2)c1)Nc1ccc(Cl)c(C(F)(F)F)c1 CHEMBL4440394 IC50 7.0 nM
CC(F)(F)c1cc(NC(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)cc2F)ccc1F CHEMBL3954891 IC50 7.1 nM
Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)c(=O)n(CCS(C)(=O)=O)c1 CHEMBL3944515 IC50 7.186 nM
O/N=C1\CCc2cc(-c3cc(CN4CCOCC4)oc3-c3ccncc3)ccc21 CHEMBL476732 Kd 7.2 nM
O=C1CCc2c(Oc3ccc4c(c3)C3C(O4)C3c3nc4ccc(C(F)(F)F)cc4[nH]3)ccnc2N1 CHEMBL3901590 IC50 7.2 nM
O=C1CCc2c(Oc3ccc4c(c3)C3C(O4)C3c3nc4ccc(Br)cc4[nH]3)ccnc2N1 CHEMBL3916469 IC50 7.2 nM
Cc1cc(Oc2ccnc(NC(=O)C3CC3)c2)ncc1NC(=O)Nc1cc(C(F)(F)F)ccc1F CHEMBL3948208 IC50 7.2 nM
O=S1(=O)N(CCNc2nccc(-c3c(-c4cccc(O)c4)nc4sccn34)n2)CCN1Cc1ccccc1 CHEMBL5092329 IC50 7.25 nM
Cc1ccc(NC(=O)c2ccnc(C(F)F)c2)cc1-c1cc(N2CCOCC2)c(=O)n(C)c1 CHEMBL3960706 IC50 7.267 nM
CN(C)c1cc(N2C[C@@H]3C[C@H]2CN3C)ccc1-c1ccnc2c(-c3cccc4[nH]ncc34)c(-c3ccncc3)nn12 CHEMBL1276173 IC50 7.3 nM
O=C(Nc1ccc(Cl)c(C(F)(F)F)c1)Nc1ccc(Oc2ccnc(NC(=O)C3CC3)c2)cc1F CHEMBL3894725 IC50 7.3 nM
Cc1ccc(C(=O)Nc2ccc(OCCCN3CCOCC3)c(C(F)(F)F)c2)cc1NC(=O)C1(c2ncnc3[nH]ccc23)CC1 CHEMBL4439157 IC50 7.4 nM
Cc1ccc(C(=O)Nc2cccc(C(C)C)c2)cc1Nc1ncccc1-c1ncnc2c1ncn2C CHEMBL3354841 IC50 7.44 nM
CCCS(=O)(=O)Nc1cc(F)cc(C(=O)Nc2cnc3[nH]nc(OC)c3c2)c1F CHEMBL1822073 IC50 7.5 nM
CNc1ncc2cc(-c3ccc(F)c(NC(=O)NCCC(C)(C)C)c3)c(C)nc2n1 CHEMBL3577119 IC50 7.6 nM
CC(=O)Nc1nccc(-c2sc(CCCN)nc2-c2cccc(NS(=O)(=O)c3cc(F)ccc3F)c2F)n1 CHEMBL5197265 IC50 7.6 nM
Cc1ncc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cc(N2CCOCC2)n(C)c(=O)c1 CHEMBL3929643 IC50 7.69 nM
CNc1cc2nc(C)c(-c3cc(NC(=O)NC[C@@H](O)C(C)(C)C)c(F)cc3C)cc2cn1 CHEMBL3577117 IC50 7.7 nM
CC(F)(F)c1ccc(F)c(NC(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)cc2F)c1 CHEMBL3913137 IC50 7.8 nM
COc1ccc(S(=O)(=O)NCCCNc2nccc(-c3[nH]c(-c4ccccc4)nc3-c3ccc(Cl)c(O)c3)n2)cc1 CHEMBL4741154 IC50 7.81 nM
O=C(c1ccc(Br)o1)N1N=C(c2cccnc2)CC1c1ccccc1O CHEMBL1782185 IC50 7.9 nM
Cc1cc(F)c(NC(=O)NCCC(C)(C)C)cc1-c1cc2cnc(N)nc2nc1C CHEMBL3577122 IC50 7.9 nM
CN1CCC(Nc2cc(NC(=O)Nc3ccc(Oc4ccnc(NC(=O)C5CC5)c4)c(F)c3)cc(C(F)(F)F)c2)CC1 CHEMBL3893285 IC50 7.9 nM
CN1CCC(Nc2ccc(NC(=O)Nc3ccc(Oc4ccnc(NC(=O)C5CC5)c4)c(F)c3)cc2C(F)(F)F)CC1 CHEMBL3964493 IC50 7.9 nM
Oc1cccc(-c2nc(-c3ccccc3)[nH]c2-c2ccncc2)c1 CHEMBL304624 Kd 8.0 nM
CNC(=O)c1cc(Oc2ccc3c(c2)nc(Nc2cccc(C(F)(F)F)c2)n3C)ccn1 CHEMBL513562 IC50 8.0 nM
O=C(Nc1ccc(Cl)c(C(F)(F)F)c1)Nc1ccc(Oc2ccnc3[nH]c(=O)[nH]c23)cc1F CHEMBL496020 IC50 8.0 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)cnc34)c3ccccc23)n(-c2ccccc2)n1 CHEMBL1214131 IC50 8.0 nM
Cc1nc2c(Oc3ccc(NC(=O)Nc4cc(C(C)(C)C)nn4-c4ccccc4)c4ccccc34)ccnc2[nH]c1=O CHEMBL1214132 IC50 8.0 nM
NCc1cc(NC(=O)C2CCc3ccc(Oc4ccnc(NC(=O)C5CC5)c4)cc3C2)cc(C(F)(F)F)c1 CHEMBL1688868 IC50 8.0 nM
CN1CCC(n2cc(-c3ccc4c(c3)Cc3c[nH]nc3-4)c(-c3ccncc3)n2)CC1 CHEMBL1780166 IC50 8.0 nM
O=C(c1ccc(-c2cccc(CN3CCCC3)c2)s1)N1N=C(c2cccnc2)CC1c1c(O)cccc1F CHEMBL1778665 IC50 8.0 nM
O=C(c1cc(-c2ccccc2)on1)N1N=C(c2cccnc2)CC1c1ccccc1O CHEMBL1782336 IC50 8.0 nM
O=C(c1cc(-c2ccccc2)no1)N1N=C(c2cccnc2)CC1c1ccccc1O CHEMBL1782335 IC50 8.0 nM
O=C(Nc1cccc(Nc2cc3c(cc2Cl)C(=O)NC3=O)c1)c1cccc(I)c1 CHEMBL1922475 IC50 8.0 nM
O=C(Nc1cccc(Nc2cc3c(=O)[nH][nH]c(=O)c3cc2Cl)c1)c1cccc(I)c1 CHEMBL1922596 IC50 8.0 nM
C[C@@H](NC1=CC(=O)NCC1)c1ccc(Nc2ncc3cc(-c4ccncc4)ccc3n2)cc1 CHEMBL2335905 IC50 8.0 nM
CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]c(-c4ccccc4F)nc3c2)c1F CHEMBL2436799 IC50 8.0 nM
CCCS(=O)(=O)Nc1ccc(F)c(N(C)c2ccc3ncn(C)c(=O)c3c2)c1Cl CHEMBL3236467 IC50 8.0 nM
CNc1ncc2cc(-c3c(C)ccc(C(=O)Nc4ccc(OC)c(C(F)(F)F)c4)c3N)ccc2n1 CHEMBL3407847 IC50 8.0 nM
CNc1ncc2ccc(Oc3cc(C(=O)c4c(-c5ccccc5)n(C)n(-c5ccccc5)c4=O)ccc3C)cc2n1 CHEMBL3407849 IC50 8.0 nM
CNS(=O)(=O)c1ccc(N2CCOCC2)c(Nc2ncnc3[nH]ccc23)c1 CHEMBL3613196 IC50 8.0 nM
CNS(=O)(=O)c1ccc(N2CCOCC2)c(Nc2ncnc3[nH]c(Br)cc23)c1 CHEMBL3613308 IC50 8.0 nM
Cn1cc(S(=O)(=O)Nc2ccc(F)c(Nc3ncccc3-c3ncnc4[nH]cnc34)c2F)cn1 CHEMBL3799568 IC50 8.0 nM
O=S(=O)(CC1CC1)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F CHEMBL3798570 IC50 8.0 nM
CN(C)S(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F CHEMBL3798256 IC50 8.0 nM
CNc1nccc(-c2cn(C(C)C)nc2-c2cc(Cl)cc(NS(C)(=O)=O)c2F)n1 CHEMBL3927112 IC50 8.0 nM
COC(=O)N[C@@H](C)CNc1nccc(-c2nc(C3CC3)[nH]c2-c2cccc(NS(C)(=O)=O)c2)n1 CHEMBL3651705 IC50 8.0 nM
Cc1ccc(NC(=O)c2cccc(C(C)(C)C#N)c2)cc1Nc1ncnc2ccc(N3CCN(C)CC3)nc12 CHEMBL3659964 IC50 8.0 nM
Cc1ccc(C(=O)Nc2cc(N(C)CCN(C)C)cc(C(F)(F)F)c2)cc1Nc1ncnc2c(N)nc(N(C)C)nc12 CHEMBL3694035 IC50 8.0 nM
COc1ccc(C(=O)Nc2ccc(OC)c(C(F)(F)F)c2)cc1Nc1ncnc2cnc(NCCN(C)C)nc12 CHEMBL3694090 IC50 8.0 nM
CC(C)(C)c1cc(NC(=O)c2ccc(Cl)c(Nc3ncnc4cnc(N5CCCCCC5)nc34)c2)no1 CHEMBL3694131 IC50 8.0 nM
COc1ccc(C(=O)Nc2cc(C(C)(C)C)on2)cc1Nc1ncnc2cnc(N(C)C)nc12 CHEMBL3694146 IC50 8.0 nM
COc1ccc(C(F)(F)F)cc1NC(=O)c1ccc(C)c(Nc2ncnc3cnc(N4CCCN(C)CC4)nc23)c1 CHEMBL3697765 IC50 8.0 nM
Cc1ccc(C(=O)Nc2ccc3c(c2)C(C)(C)C(=O)N3CCN2CCCC2)cc1Nc1ncnc2cnc(N3CCCN(C)CC3)nc12 CHEMBL3697798 IC50 8.0 nM
Cc1ccc(C(=O)Nc2cc(C(F)(F)F)ccn2)cc1Nc1ncnc2cnc(N3CCCCC3)nc12 CHEMBL3697879 IC50 8.0 nM
Cc1cc(C(=O)Nc2cc(C(C)(C)C)nn2C)cc(Nc2ncnc3cnc(N4CCN(C)CC4)nc23)c1C CHEMBL3697914 IC50 8.0 nM
CN1CCN(c2ncc3ncnc(Nc4cc(Cl)cc(C(=O)Nc5cc(C(C)(C)C)nn5C)c4)c3n2)CC1 CHEMBL3697919 IC50 8.0 nM
Cc1ccc(C(=O)Nc2cc(C(C)(C)C)n[nH]2)cc1Nc1ncnc2cnc(N3CCN(C)CC3)nc12 CHEMBL3641074 IC50 8.0 nM
Cc1ccc(C(=O)Nc2cc(N3CCN(CC(C)C)CC3)cc(C(F)(F)F)c2)cc1Nc1ncnc2cnc(N3CC[C@H](F)C3)nc12 CHEMBL3641078 IC50 8.0 nM
COCCN1CCN(c2ncc3ncnc(Nc4cc(C(=O)Nc5cc(-n6cnc(C)c6)cc(C(F)(F)F)c5)ccc4C)c3n2)CC1 CHEMBL3641117 IC50 8.0 nM
COc1ccc(NC(=O)c2ccc(C)c(Nc3ncnc4cnc(-n5cnc(C)c5)nc34)c2)cc1C(F)(F)F CHEMBL3641164 IC50 8.0 nM
Cc1ccc(C(=O)Nc2cc(C(C)(C)C)on2)cc1-n1cc(-c2cncc(N3CCN(C)CC3)c2)nn1 CHEMBL3893769 IC50 8.0 nM
Cc1ccc(C(=O)Nc2cc(C(C)(C)C)on2)cc1-n1cc(-c2cncc(N(C)C3CCOC3)c2)nn1 CHEMBL3969597 IC50 8.0 nM
CCCN1CCN(c2cncc(-c3cn(-c4cc(C(=O)Nc5cc(C(C)(C)C)on5)ccc4C)nn3)c2)CC1 CHEMBL3974879 IC50 8.0 nM
Cc1ccc(C(=O)Nc2cc(C(F)(F)F)ccn2)cc1-n1cc(-c2cncc(N3CCC(N(C)C)CC3)c2)nn1 CHEMBL3901325 IC50 8.0 nM
Cc1ccc(C(=O)Nc2cc(C(F)(F)F)ccn2)cc1-n1cc(-c2cncc(N3CCN(C(C)C)CC3)c2)nn1 CHEMBL3927531 IC50 8.0 nM
Cc1ccc(C(=O)Nc2cc(C(C)(C)C)on2)cc1-n1cc(-c2cncc(N3CCCN(C)CC3)c2)nn1 CHEMBL3919327 IC50 8.0 nM
Cc1ccc(C(=O)Nc2cc(C(C)(C)C)on2)cc1-n1cc(-c2cncc(N3CCC(N4CCN(C(C)C)CC4)C3)c2)nn1 CHEMBL3903762 IC50 8.0 nM
Cc1ccc(C(=O)Nc2cc(C(C)(C)C)on2)cc1-n1cc(-c2cncc(N3CC(N4CCN(C)CC4)C3)c2)nn1 CHEMBL3928229 IC50 8.0 nM
Cc1ccc(NC(=O)c2cc(C(C)(C)C)on2)cc1-n1cc(-c2cncc(N3CCOCC3)c2)nn1 CHEMBL3890824 IC50 8.0 nM
Cc1ccc(NC(=O)c2cc(C(C)(C)C)nn2C)cc1-n1cc(-c2cncc(N3CCN(C)CC3)c2)nn1 CHEMBL3969226 IC50 8.0 nM
CCN1CCN(c2cncc(-c3cn(-c4cc(NC(=O)c5ccc(C(C)(C)C)s5)ccc4C)nn3)c2)CC1 CHEMBL3975908 IC50 8.0 nM
Cc1ccc(NC(=O)c2ccc(C(C)(C)C)s2)cc1-n1cc(-c2cncc(N3CCN(CC4CC4)CC3)c2)nn1 CHEMBL3952224 IC50 8.0 nM
CCn1nc(C#Cc2c(C)ccc3c(Nc4ccc(Cl)cc4)nccc23)c2c(N)ncnc21 CHEMBL4593051 IC50 8.0 nM
Cc1ccc(S(=O)(=O)NCCCNc2nccc(-c3[nH]c(-c4ccccc4)nc3-c3ccc(Cl)c(O)c3)n2)cc1 CHEMBL4763666 IC50 8.04 nM
CC(C)c1cccc(NC(=O)c2ccc(Cl)c(Nc3ncccc3-c3ncnc4[nH]cnc34)c2)c1 CHEMBL3354390 IC50 8.07 nM
Cc1nc(-c2cccnc2)sc1C(=O)N1N=C(c2cccnc2)CC1c1ccccc1O CHEMBL1782343 IC50 8.1 nM
CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]cc(N(C)C)c3c2)c1F CHEMBL4286375 pIC50 8.128 nM
COc1cccc(-c2c(-c3ccncc3)nn3c(-c4ccc(N5C[C@@H]6C[C@H]5CN6C)cc4)ccnc23)c1 CHEMBL1080615 IC50 8.2 nM
CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]nc(N(C)C)c3c2)c1F CHEMBL1945164 IC50 8.2 nM
CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3cc(-c4ccc(Cl)cc4)nn3c2)c1F CHEMBL2436810 IC50 8.2 nM
CCCS(=O)(=O)Nc1ccc(Cl)c(C(=O)Nc2cnc3[nH]ccc3c2)c1Cl CHEMBL1822080 IC50 8.3 nM
CC(F)(F)c1cc(NC(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)cc2F)ccc1Cl CHEMBL3909831 IC50 8.3 nM
COc1cccc(-c2nc3sccn3c2-c2ccnc(NCCN3CCN(Cc4ccccc4)S3(=O)=O)n2)c1 CHEMBL5088157 IC50 8.36 nM
CCn1cc(-c2cc(NC(=O)c3ccnc(C(F)(F)F)c3)ccc2C)cc(N2CCOCC2)c1=O CHEMBL3955962 IC50 8.383 nM
CCOC(=O)N1C2CCC1CC(c1c(C)cnc3c(-c4cccc5[nH]ncc45)c(-c4ccncc4)nn13)C2 CHEMBL585335 IC50 8.4 nM
CNc1cc(C2(C(=O)Nc3cc(C(=O)Nc4ccc(Cl)cc4)ccc3C)CC2)ncn1 CHEMBL4071785 IC50 8.4 nM
COC(=O)NC[C@@H]1CN(c2cc(-c3cc(NC(=O)c4cccc(C(F)(F)F)c4)cnc3C)ccn2)CCO1 CHEMBL4111858 IC50 8.43 nM
COc1cc(-c2c(-c3ccncc3)nn3c(C4CC5CCC(C4)N5)ccnc23)ccc1Cl CHEMBL583678 IC50 8.5 nM
CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(-c4ccc(C(=O)NCCOCCOCC(=O)N[C@H](C(=O)N5C[C@H](O)C[C@H]5C(=O)NCc5ccc(-c6scnc6C)cc5)C(C)(C)C)cc4)cc23)c1F CHEMBL5175716 IC50 8.5 nM
O=C(c1cc(-c2ccc3c(c2)OCO3)on1)N1N=C(c2cccnc2)CC1c1ccccc1O CHEMBL1782340 IC50 8.6 nM
COc1n[nH]c2ncc(NC(=O)c3c(F)ccc(NS(=O)(=O)N4CCCC4)c3F)cc12 CHEMBL1822099 IC50 8.6 nM
COc1ccc(NC(=O)Nc2cnc(Oc3ccnc(NC(=O)C4CC4)c3)c(C)c2)cc1C(F)(F)F CHEMBL3964796 IC50 8.6 nM
COc1cccc(-c2nc3sccn3c2-c2ccnc(NCCN3CC(C)(C)NS3(=O)=O)n2)c1 CHEMBL5092112 IC50 8.65 nM
Cc1ccc(S(=O)(=O)NCCCNc2nccc(-c3[nH]c(-c4ccccc4)nc3-c3ccc(F)c(O)c3)n2)cc1 CHEMBL4779919 IC50 8.68 nM
COc1cc(-c2c(-c3ccncc3)nn3c(-c4ccc(N5C[C@@H]6C[C@H]5CN6)cc4)ccnc23)ccc1F CHEMBL1079785 IC50 8.7 nM
CCCS(=O)(=O)Nc1ccc(F)c(-c2ccc3cc(N)ncc3c2)c1F CHEMBL2023335 IC50 8.7 nM
Cc1ncc(NC(=O)c2cccc(C(F)(F)F)c2)cc1-c1cnnc(N2CCOCC2)c1 CHEMBL3925869 IC50 8.715 nM
O=S(=O)(Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F)c1cccc(C(F)(F)F)c1 CHEMBL3964313 IC50 8.8 nM
Cc1cc(Oc2ccnc(NC(=O)C3CC3)c2)ccc1NC(=O)Nc1cccc(OC(F)(F)F)c1 CHEMBL3985123 IC50 8.8 nM
Oc1cc(Nc2ncnc3ccc(-c4ccc(Cl)cc4)cc23)c(F)cc1F CHEMBL3665861 IC50 8.9 nM
CC(F)(F)c1cc(F)cc(NC(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)cc2F)c1 CHEMBL3984219 IC50 8.9 nM
CC(F)(F)c1cccc(NC(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)cc2F)c1 CHEMBL3980939 IC50 8.9 nM
CCCS(=O)(=O)Nc1ccc(F)c(-c2cc3cnc(NC)nc3n(C)c2=O)c1F CHEMBL2023341 pIC50 8.913 nM
Cc1ccc(NC(=O)c2ccc(Cl)c(C(F)(F)F)c2)cc1C(=O)Nc1cccnc1 CHEMBL475865 IC50 9.0 nM
Cn1cc(-c2ccc(C(=O)N3N=C(c4cccnc4)CC3c3ccccc3O)s2)cn1 CHEMBL1779286 IC50 9.0 nM
CC(=O)N1CCN(c2ccc(Nc3nccc(-c4sc(C(C)C)nc4-c4cccc(NS(=O)(=O)c5ccc(F)cc5)c4)n3)cn2)CC1 CHEMBL1808257 EC50 9.0 nM
CN1CCc2ccc(Nc3nccc(-c4c(-c5cccc(NC(=O)c6c(F)cccc6F)c5)nc5ccccn45)n3)cc2C1 CHEMBL1807707 IC50 9.0 nM
CN(C)CCOc1ccc(-c2nc(-c3ccc4c(O)cccc4c3)c(-c3ccncc3)[nH]2)cc1 CHEMBL2336826 IC50 9.0 nM
CC(=O)Nc1cc(Oc2ccc3c(c2)nc(Nc2ccc(C(C)(C)C)cc2)n3C)ccn1 CHEMBL3335376 IC50 9.0 nM
CCCS(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F CHEMBL3798357 IC50 9.0 nM
O=S(=O)(Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F)N1CC[C@H](O)C1 CHEMBL3800002 IC50 9.0 nM
Cc1ccc(C(=O)Nc2cc(C(C)(C)C)on2)cc1Nc1ncnc2ccc(N(C)C)nc12 CHEMBL3659924 IC50 9.0 nM
Cc1ccc(C(=O)Nc2cc(Br)cc(C(F)(F)F)c2)cc1Nc1ncnc2c(N)nc(N3CCN(C)CC3)nc12 CHEMBL3689902 IC50 9.0 nM
Cc1ccc(C(=O)Nc2ccc(C(F)(F)F)cc2)cc1Nc1ncnc2c(N)nc(N3CCCN(C)CC3)nc12 CHEMBL3639887 IC50 9.0 nM
CN1CCCN(c2nc(N)c3ncnc(Nc4cc(C(=O)Nc5cccc(C(F)(F)F)c5)ccc4Cl)c3n2)CC1 CHEMBL3689923 IC50 9.0 nM
Cc1ccc(C(=O)Nc2cc(C(C)(C)C)n[nH]2)cc1Nc1ncnc2c(N)nc(N3CCN(C4CC4)CC3)nc12 CHEMBL3689941 IC50 9.0 nM
CCN1CCN(c2cc(NC(=O)c3ccc(C)c(Nc4ncnc5c(N)nc(N6CCCC6)nc45)c3)cc(C(F)(F)F)c2)CC1 CHEMBL3694044 IC50 9.0 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1Nc1ncnc2c(N)nc(N3CC4CC3CN4C)nc12 CHEMBL3694062 IC50 9.0 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1Nc1ncnc2c(N)nc(N3CCNCC3)nc12 CHEMBL3694063 IC50 9.0 nM
COc1ccc(NC(=O)c2ccc(Cl)c(Nc3ncnc4cnc(N5CCCC5)nc34)c2)cc1C(F)(F)F CHEMBL3694076 IC50 9.0 nM
Cc1ccc(C(=O)Nc2cc(N(C)CCN(C)C)cc(C(F)(F)F)c2)cc1Nc1ncnc2cnc(N3CCC(F)(F)CC3)nc12 CHEMBL3694225 IC50 9.0 nM
COc1ccc(C(F)(F)F)cc1NC(=O)c1ccc(C)c(Nc2ncnc3cnc(N4CCCCC4)nc23)c1 CHEMBL3697808 IC50 9.0 nM
Cc1ccc(C(=O)Nc2ccc(F)c(C(F)(F)F)c2)cc1Nc1ncnc2cnc(N3CCOCC3)nc12 CHEMBL3697859 IC50 9.0 nM
COc1ccc(NC(=O)c2ccc(C)c(Nc3ncnc4cnc(N(C)CC5CCCCO5)nc34)c2)cc1C(F)(F)F CHEMBL3641036 IC50 9.0 nM
CCN1CCN(c2ncc3ncnc(Nc4cc(C(=O)Nc5ccc(OC)c(C(F)(F)F)c5)ccc4C)c3n2)CC1 CHEMBL3641176 IC50 9.0 nM
Cc1ccc(C(=O)Nc2cc(C(C)(C)C)n[nH]2)cc1Nc1ncnc2cnc(N3CCN(CC4CCOC4)CC3)nc12 CHEMBL3641206 IC50 9.0 nM
Cc1ccc(NC(=O)c2cc(N3CCN(C)CC3)cc(C(F)(F)F)c2)cc1Nc1ncnc2cnc(N(C)CCN(C)C)nc12 CHEMBL3641223 IC50 9.0 nM
Cc1ccc2c(Nc3cccc(Cl)c3)nccc2c1NC(=O)c1csc2c(N)ncnc12 CHEMBL3954810 IC50 9.0 nM
CCN1CCC2(CCN(c3cncc(-c4cn(-c5cc(C(=O)Nc6cc(C(C)(C)C)on6)ccc5C)nn4)c3)C2)C1 CHEMBL3980523 IC50 9.0 nM
Cc1ccc(C(=O)Nc2cc(C(C)(C)C)on2)cc1-n1cc(-c2cncc(N3CC(C)NC(C)C3)c2)nn1 CHEMBL3971786 IC50 9.0 nM
Cc1ccc(C(=O)Nc2cc(C(C)(C)C)on2)cc1-n1cc(-c2cncc(NCC3CCCO3)c2)nn1 CHEMBL3960659 IC50 9.0 nM
Cc1ccc(C(=O)Nc2cc(C(F)(F)F)ccn2)cc1-n1cc(-c2cncc(N(C)CCN3CCCC3)c2)nn1 CHEMBL3956709 IC50 9.0 nM
Cc1ccc(C(=O)Nc2cc(C(F)(F)F)ccn2)cc1-n1cc(-c2cncc(N3CC[C@H](N(C)C)C3)c2)nn1 CHEMBL3960521 IC50 9.0 nM
Cc1ccc(NC(=O)c2cc(C(F)(F)F)ccn2)cc1-n1cc(-c2cncc(N3CCOCC3)c2)nn1 CHEMBL3918381 IC50 9.0 nM
Cc1ccc(NC(=O)c2ccc(C(C)(C)C)o2)cc1-n1cc(-c2cncc(N3CCOCC3)c2)nn1 CHEMBL3906046 IC50 9.0 nM
CCCN1CCN(c2cncc(-c3cn(-c4cc(NC(=O)c5ccc(C(C)(C)C)s5)ccc4C)nn3)c2)CC1 CHEMBL3970814 IC50 9.0 nM
Cc1ccc(NC(=O)c2cc(C)n(C(C)(C)C)n2)cc1-n1cc(-c2cncc(N3CCCN(C)CC3)c2)nn1 CHEMBL3894425 IC50 9.0 nM
O=C(Nc1ccc(Oc2ccnc(NC(=O)C3CC3)c2)cc1F)Nc1cc(C(F)(F)F)ccc1F CHEMBL3908336 IC50 9.0 nM
COc1n[nH]c2ncc(NC(=O)c3c(F)ccc(/N=N\c4ccc(C)cc4)c3F)cc12 CHEMBL4547542 IC50 9.0 nM
Cc1ccc(S(=O)(=O)NCCCNc2nccc(-c3c(-c4cccc(O)c4)nc4sccn34)n2)cc1 CHEMBL5077391 IC50 9.0 nM
COc1ccc(C(=O)Nc2cnc(C)c(-c3ccnc(N4CCOCC4)c3)c2)cc1C(F)(F)F CHEMBL3964522 IC50 9.087 nM
CC(=O)N1C2CCC1CC(c1ccnc3c(-c4cccc5[nH]ncc45)c(-c4ccncc4)nn13)C2 CHEMBL570458 IC50 9.1 nM
O=C(c1cn2c(n1)sc1ccccc12)N1N=C(c2cccnc2)CC1c1ccccc1O CHEMBL1782348 IC50 9.1 nM
O=C(Nc1cnc(Oc2ccnc(NC(=O)C3CC3)c2)c(F)c1)Nc1ccc(Cl)c(C(F)(F)F)c1 CHEMBL3972376 IC50 9.1 nM
CN1CC(Oc2cc(NC(=O)Nc3ccc(Oc4ccnc(NC(=O)C5CC5)c4)cc3)cc(C(F)(F)F)c2)C1 CHEMBL3971428 IC50 9.1 nM
CCCS(=O)(=O)Nc1ccc(F)c(C(=O)Nc2cnc3[nH]nc(CC)c3c2)c1F CHEMBL1822244 IC50 9.2 nM
Cc1ccc(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1-c1cc2[nH]cnc2c(N2CCOCC2)n1 CHEMBL3971983 IC50 9.218 nM
O=S(=O)(NCCCNc1nccc(-c2c(-c3cccc(F)c3)nc3sccn23)n1)c1ccc(Br)cc1 CHEMBL4757872 IC50 9.3 nM
O=C(Nc1cccc(OC(F)(F)F)c1)Nc1ccc(Oc2ccnc(NC(=O)C3CC3)c2)cc1F CHEMBL3910983 IC50 9.4 nM
N#Cc1c(Oc2cccc(NC(=O)Cc3ccc(C(F)(F)F)cc3)c2)ccc2nc(NC(=O)C3CC3)sc12 CHEMBL3125889 IC50 9.5 nM
O=C1CCc2c(Oc3ccc4c(c3)C[C@H](NC(=O)c3cc(-c5cc[nH]n5)cc(C(F)(F)F)c3)CC4)ccnc2N1 CHEMBL3765074 IC50 9.5 nM
CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(-c4ccc(CNC(=O)CCCCNc5ccc6c(c5)C(=O)N(C5CCC(=O)NC5=O)C6=O)cc4)cc23)c1F CHEMBL4541406 Kd 9.5 nM
Cc1ccc(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1-c1cc(N2CCOCC2)c(=O)n(C)n1 CHEMBL3942212 IC50 9.525 nM
CC(C)(C)OC(=O)N1CCCN(CCNc2nccc(-c3c(-c4cccc(O)c4)nc4sccn34)n2)S1(=O)=O CHEMBL5077895 IC50 9.57 nM
CN1C[C@@H]2C[C@H]1CN2c1c(F)cc(-c2ccnc3c(-c4cccc5[nH]ncc45)c(-c4ccncc4)nn23)cc1F CHEMBL1276180 IC50 9.6 nM
COc1cccc(NC(=O)Nc2cccc(-c3csc4c(-c5cccnc5)cnc(N)c34)c2)c1 CHEMBL2315077 IC50 9.6 nM
CC(C)CC1(C)OC(c2ccnc(NCCC#N)n2)=C(c2cccc(NS(=O)(=O)c3c(F)cccc3F)c2F)C1=O CHEMBL3899076 IC50 9.6 nM
COc1cc(-c2c(-c3ccncc3)nn3c(-c4ccc(N5CC6CCC(C5)N6C)cc4)ccnc23)ccc1Cl CHEMBL1088288 IC50 9.7 nM
CCn1cc(-c2cc(NC(=O)c3ccnc(C(C)(C)C#N)c3)ccc2C)cc(N2CCOCC2)c1=O CHEMBL3942103 IC50 9.738 nM
O=C(Nc1cccc(OC(F)(F)F)c1)Nc1ccc(Oc2ccnc(NC(=O)C3CC3)c2)c(F)c1 CHEMBL3959341 IC50 9.8 nM
COc1cccc(-c2nc3sccn3c2-c2ccnc(NCCN3CCCNS3(=O)=O)n2)c1 CHEMBL5089022 IC50 9.96 nM
Cc1ccc(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1-c1cc(N2CCOCC2)c(=O)n(CCO)c1 CHEMBL3925508 IC50 9.98 nM