Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)NCc1ccon1)c1nnc(C)n1-2 CHEMBL5440537 IC50 0.1 nM
Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)NCc1ncco1)c1nnc(C)n1-2 CHEMBL5440963 IC50 0.1 nM
COC(=O)CNC(=O)C[C@@H]1N=C(c2ccc(Cl)cc2)c2c(sc(C)c2C)-n2c(C)nnc21 CHEMBL5424952 IC50 0.1 nM
Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)Nc1nncs1)c1nnc(C)n1-2 CHEMBL5432745 IC50 0.1 nM
[2H]C([2H])([2H])c1nnn(C)c1-c1cnc2c3cc(F)c(C(C)(C)O)cc3n([C@H](c3ccccc3)C3CCOCC3)c2c1 CHEMBL4859923 IC50 0.2 nM
Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)NCc1ccccc1)c1nnc(C)n1-2 CHEMBL5401253 IC50 0.2 nM
CCn1nc(C2CC2)cc1Nc1nc(C(=O)NC)nc2[nH]c3cc(-c4c(C)noc4C)c(OC)cc3c12 CHEMBL4228445 Ki 0.27 nM
CCS(=O)(=O)Nc1cc(-c2cn(C)c3c(=O)[nH]ccc23)cc2c1ccn2C(C)(c1ccccn1)c1ccccn1 CHEMBL4648912 Kd 0.27 nM
Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)NCc1ccccn1)c1nnc(C)n1-2 CHEMBL5436475 IC50 0.3 nM
Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)NCC(=O)O)c1nnc(C)n1-2 CHEMBL5422881 IC50 0.3 nM
Cn1cc2c3c(c[nH]c3c1=O)CN(c1ccccn1)c1ccc(CS(C)(=O)=O)cc1-2 CHEMBL4208129 Ki 0.48 nM
Cc1ccc2ncccc2c1-c1cc(-c2c(C)noc2C)cc2nc(C3CC3)[nH]c12 CHEMBL3926851 Kd 0.59 nM
COc1cc2c(cc1-c1c(C)noc1C)[nH]c1nc(C)nc(Nc3cc(C4CC4)nn3C)c12 CHEMBL4173488 Kd 0.6 nM
Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@H](CC(=O)OC(C)(C)C)c1nnc(C)n1-2 CHEMBL3220211 K 0.89 nM
COc1cc2c(cc1-c1c(C)noc1C)[nH]c1nc(C)nc(-c3ccnc4ccccc34)c12 CHEMBL4171228 Kd 0.9 nM
CCNC(=O)c1cc2c(-c3cc(C(C)(C)O)ccc3Oc3c(C)cc(F)cc3C)cn(C)c(=O)c2[nH]1 CHEMBL4297454 IC50 0.92 nM
CCS(=O)(=O)Nc1ccc(Oc2ccc(F)cc2F)c(-c2cn(C)c(=O)c3[nH]ccc23)c1 CHEMBL3987016 Ki 1.0 nM
Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)NCc1c[nH]nn1)c1nnc(C)n1-2 CHEMBL5422163 IC50 1.0 nM
Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)OCC(C)(COCCOCCOCCNC(=O)C[C@@H]2N=C(c3ccc(Cl)cc3)c3c(sc(C)c3C)-n3c(C)nnc32)COCCOCCOCCNC(=O)C[C@@H]2N=C(c3ccc(Cl)cc3)c3c(sc(C)c3C)-n3c(C)nnc32)C(C)(C)C)cc1 CHEMBL5279987 DC50 1.1 nM
Cc1nnc2n1-c1ccc(-c3cnn(C)c3)cc1[C@H](Nc1ccc(Cl)cc1)CC2 CHEMBL4528047 Kd 1.2 nM
CCS(=O)(=O)Cc1cnc(Oc2ccc(F)cc2F)c(-c2cc(C)c3c(=O)[nH]ccn23)c1 CHEMBL4440098 Kd 1.3 nM
Cc1nnn(C)c1-c1cnc2c3ccc(C(C)(C)O)cc3n([C@H](c3ccccc3)C3CCOCC3)c2c1 CHEMBL4297458 IC50 1.4 nM
Cc1noc(C)c1-c1ccc2c(n1)c(-c1ccc(C(=O)O)cc1)cn2[C@H](C)c1ccccn1 CHEMBL5273240 Kd 1.6 nM
Cc1nnc2n1-c1sc(C#Cc3cnn(C)c3)c(Cc3ccccc3)c1COC2 CHEMBL4555209 Ki 1.7 nM
Cc1noc(C)c1-c1cnc2c3ccc(C(C)(C)O)cc3n([C@H](c3ccccc3)C3CCOCC3)c2c1 CHEMBL5087175 IC50 1.7 nM
Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)NCCO)c1nnc(C)n1-2 CHEMBL5400310 IC50 2.0 nM
Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)Nc1nccs1)c1nnc(C)n1-2 CHEMBL5439607 IC50 2.0 nM
Cn1cc2c3c(c[nH]c3c1=O)CN(c1ccc(F)cc1F)c1ccc(CS(C)(=O)=O)cc1-2 CHEMBL4217457 Ki 2.5 nM
CNC(=O)c1cc(C(=O)N[C@H]2[C@@H]3C[C@@H](O)C[C@@H]32)cc2c1OC[C@@]2(C)c1ccccc1 CHEMBL4869149 pIC50 2.512 nM
Cn1cc2c3c(c[nH]c(=O)c31)-c1cc(CS(C)(=O)=O)ccc1N(c1ccc(F)cc1)C2 CHEMBL4215988 Ki 2.6 nM
Cc1nnn2c1-c1ccc(C(=O)N[C@@H](C)c3ccccc3)cc1N(c1ccc(Cl)cc1)CC2 CHEMBL4162832 IC50 3.0 nM
Cc1nnc2n1-c1ccc(-c3ccc(N)nc3)cc1N(c1ccc(Cl)cc1)C[C@H]2C CHEMBL4780530 IC50 3.0 nM
Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)Nc1ccc(O)cc1)c1nnc(C)n1-2 CHEMBL3581647 IC50 3.0 nM
Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)NCc1cn(C)cn1)c1nnc(C)n1-2 CHEMBL5403848 IC50 3.0 nM
CC(=O)N1c2ccc(-c3ccc(C(=O)O)cc3)cc2[C@H](Nc2ccc(Cl)cc2)C[C@@H]1C CHEMBL2177300 pIC50 3.162 nM
Cc1cc(-c2nc3ccccc3n2C[C@@H]2CCCN(C(=O)C3CCN(C(C)C)CC3)C2)cn(C)c1=O CHEMBL5405343 pKd 3.162 nM
Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)OC(C)(C)C)c1nnc(C)n1-2 CHEMBL1957266 IC50 3.93 nM
Cc1cc2c(-c3ccco3)cnc(N[C@@H]3CCN(C)C[C@H]3C(=O)NC3CCCCC3)c2[nH]c1=O CHEMBL4648362 pKd 3.981 nM
Cc1nnn2c1-c1ccc(C(=O)N[C@@H](C)c3ccc(F)cc3)cc1N(c1ccc(Cl)cc1)CC2 CHEMBL4173537 IC50 4.0 nM
Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCCOCCNC(=O)C[C@@H]2N=C(c3ccc(Cl)cc3)c3c(sc(C)c3C)-n3c(C)nnc32)C(C)(C)C)cc1 CHEMBL4215078 Kd 4.7 nM
CNC(=O)c1cc(C(=O)N[C@H]2[C@@H]3COC[C@@H]32)cc2c1O[C@H](CF)[C@H]2c1ccccc1 CHEMBL4637208 pKd 5.012 nM
Cc1cc(F)cc(C)c1Oc1ccc(C(C)(C)O)cc1-c1cn(C)c(=O)c2cc(-c3cnc(C4CCCC4)[nH]3)oc12 CHEMBL5206088 IC50 5.09 nM
CN1CCC(NC(=O)c2cccc(CN3c4ccccc4C=C4c5c(cccc53)C(=O)N4C)c2)CC1 CHEMBL5393744 IC50 5.9 nM
Cc1nnn2c1-c1ccc(-c3nn[nH]n3)cc1N(c1ccc(Cl)cc1)CC2 CHEMBL4165389 IC50 6.0 nM
CC(=O)N1c2ccc(-c3cc[nH]n3)cc2[C@H](Nc2ccc(C#N)cc2)C[C@@H]1C CHEMBL5205867 Kd 6.0 nM
Cc1noc(C)c1-c1ccc2c(c1)C(c1ccccc1)(N1CCC[C@H](N)C1)C(=O)N2 CHEMBL3895413 IC50 6.6 nM
CC(=O)N1c2ccc(C(N)=O)cc2[C@H](Nc2ncc(Cl)cn2)C[C@@H]1C CHEMBL5195288 pKd 7.943 nM
Cc1nnc2n1-c1sc(C#Cc3cnn(C4CN(c5ccc6c(c5)C(=O)N(C5CCC(=O)NC5=O)C6=O)C4)c3)c(Cc3ccccc3)c1COC2 CHEMBL5406183 Kd 8.3 nM
CCn1cc(-c2ccc3c(c2)C(Nc2ccc(Cl)cc2)CCc2nnc(C)n2-3)cn1 CHEMBL4438006 Ki 8.9 nM
COc1cc2c(cc1-c1c(C)noc1C)ncc1[nH]c(=O)n([C@H](C)c3ccccn3)c12 CHEMBL2017291 Ki 9.0 nM
Cc1cc(-c2ccc3nc(C4CCOCC4)n(CCOC(F)(F)F)c3c2)cn(C)c1=O CHEMBL5274024 Kd 9.0 nM
COC(=O)C(Cc1c[nH]cn1)NC(=O)C[C@@H]1N=C(c2ccc(Cl)cc2)c2c(sc(C)c2C)-n2c(C)nnc21 CHEMBL5399489 IC50 9.0 nM
Cc1nnc2n1-c1ccc(-c3cnn(C)c3)cc1C(Nc1ccc(Cl)cc1)CC2 CHEMBL4471776 Ki 9.1 nM
Cc1noc(C)c1-c1ccc2c(c1)C(c1ccccc1)(N1CCC[C@H](O)C1)C(=O)N2 CHEMBL3903717 IC50 9.6 nM
CNC(=O)c1cc(C(=O)N[C@H]2C[C@@H]2C)cc(C(O)c2ccccc2)n1 CHEMBL4862372 pKd 10.0 nM
Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)Nc1ccc(C(=O)NO)cc1)c1nnc(C)n1-2 CHEMBL4850926 IC50 11.0 nM
Cc1cc(F)cc(C)c1Oc1ccc(C(C)(C)O)cc1-c1cn(C)c(=O)c2cc(-c3cnc(C4CCCCC4)[nH]3)oc12 CHEMBL5204783 IC50 11.07 nM
COc1cc2c(cc1-c1c(C)noc1C)[nH]c1ccnc(-c3c(C4CC4)n[nH]c3C)c12 CHEMBL3581661 Ki 11.1 nM
Cc1nn(C2CC2)c2c1[C@@H](c1ccc(Cl)cc1)N(c1cc(C)c3nnc(C)n3n1)C2=O CHEMBL3650967 IC50 12.0 nM
CCc1[nH]nc(-c2ccccc2)c1-c1nccc2[nH]c3cc(-c4c(C)noc4C)c(OC)cc3c12 CHEMBL3581662 Ki 12.2 nM
COCc1nc2cnc3cc(-c4c(C)noc4C)c(OC)cc3c2n1[C@H](C)c1ccccc1 CHEMBL4635329 pIC50 12.59 nM
COCc1nc2cnc3cc(-c4c(C)noc4C)c(OC[C@H]4CCNC4)cc3c2n1[C@H](C)c1ccccc1 CHEMBL4639128 Kd 13.0 nM
Cc1nn(C(C)C)c2c1[C@@H](c1ccc(Cl)cc1)N(c1cc(C)c(=O)n(C)c1)C2=O CHEMBL3650949 IC50 14.0 nM
CCc1nn(C2CC2)c2c1[C@@H](c1ccc(Cl)cc1)N(c1cc(C)c3nnc(C)n3c1)C2=O CHEMBL3650952 IC50 14.0 nM
Cc1[nH]c(-c2cc(NS(C)(=O)=O)ccc2Oc2ccccc2)c2c1C(=O)CCC2 CHEMBL4063051 Ki 14.0 nM
COC(=O)c1ccc(N[C@@H]2C[C@H](C)N(C(C)=O)c3ccc(-c4cccc(NC(C)=O)c4)cc32)cc1 CHEMBL5269983 Kd 14.0 nM
Cc1nn(C2CC2)c2c1[C@@H](c1ccc(Cl)cc1)N(c1cc(C)c(=O)n(C)c1)C2=O CHEMBL3650899 IC50 15.0 nM
CCc1n[nH]c(CC)c1-c1nccc2[nH]c3cc(-c4c(C)noc4C)c(OC)cc3c12 CHEMBL3581660 Ki 15.4 nM
CNC(=O)c1cc(C(=O)NC2CC2)cn(Cc2ccccc2)c1=O CHEMBL4635134 pKd 15.85 nM
Cc1cc(N2C(=O)c3c(c(CO)nn3C3CC3)[C@H]2c2ccc(Cl)cc2)cn2c(C)nnc12 CHEMBL3654324 IC50 16.0 nM
CCn1nc(C)c2c1C(=O)N(c1cc(C)c(=O)n(C)c1)C2c1ccc(Cl)cc1F CHEMBL3654293 IC50 16.0 nM
Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=NC(CC(=O)OC(C)(C)C)c1nnc(C)n1-2 CHEMBL2132936 IC50 16.0 nM
Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)NCCOCCOCCN)c1nnc(C)n1-2 CHEMBL4577491 IC50 16.0 nM
Cc1n[nH]c2c1[C@@H](c1ccc(Cl)cc1)N(c1cc(C)c3nnc(C)n3c1)C2=O CHEMBL3654323 IC50 17.0 nM
Cc1nn(C2CC2)c2c1[C@@H](c1ccc(Cl)cc1)N(c1cc(Cl)c(=O)n(C)c1)C2=O CHEMBL3650901 IC50 17.0 nM
COC(=O)[C@H](C)[C@@H]1N=C(c2ccc(Cl)cc2)c2cc(OC)ccc2-n2c(C)nnc21 CHEMBL3769729 Kd 17.0 nM
Cc1nnn2c1-c1ccc(C(N)=O)cc1N(c1ccc(Cl)cc1)CC2 CHEMBL4161767 IC50 17.0 nM
CC(=O)N1c2ccc(-c3ccsc3)cc2[C@H](NC(=O)OC(C)C)C[C@@H]1C CHEMBL4210405 Kd 17.12 nM
Cc1nn(C2CC2)c2c1C(c1ccc(Cl)cc1)N(c1cc(C)c3nnn(C)c3n1)C2=O CHEMBL3650955 IC50 18.0 nM
Cc1noc(C)c1-c1ccc2c(c1)C(O)(c1ccsc1)C(=O)N2 CHEMBL3895277 IC50 18.0 nM
Cc1nnn2c1-c1ccc(C(=O)Nc3ccccc3)cc1N(c1ccc(Cl)cc1)CC2 CHEMBL4169698 IC50 18.0 nM
COc1ccccc1S(=O)(=O)Nc1ccc2c(c1)C(=C(C)C)C(=O)N2 CHEMBL4752543 IC50 18.0 nM
Cc1nnc2n1-c1ccccc1C(c1ccccc1)=NC2NC(=O)OCc1ccccc1 CHEMBL2153434 Kd 19.0 nM
Cc1nn(C2CC2)c2c1[C@@H](c1ccc(Cl)cc1)N(c1cc(C)c3nnc(C)n3c1)C2=O CHEMBL3650964 IC50 19.0 nM
Cc1cc(-c2cc3c4c(c2)n(Cc2ccccc2)c(=O)n4CCO3)cn(C)c1=O CHEMBL5395771 IC50 19.0 nM
Cc1nnc2n1-c1ccc(-c3cn[nH]c3)cc1C(Nc1ccc(Cl)cc1)CC2 CHEMBL4533303 Ki 19.1 nM
CC(=O)N1c2ccc(-c3cc[nH]c3)cc2[C@H](NC(=O)OC(C)C)C[C@@H]1C CHEMBL4206677 Kd 19.94 nM
Cc1cc(N2C(=O)c3c(c(C4CC4)nn3C)[C@H]2c2ccc(Cl)cc2)cn2c(C)nnc12 CHEMBL3654322 IC50 20.0 nM
Cc1nn(C2CC2)c2c1C(c1ccc(Cl)cc1)N(c1cc(C)c3nnc(C(F)F)n3n1)C2=O CHEMBL3654318 IC50 20.0 nM
Cc1nnn2c1-c1ccc(C(=O)N[C@H](C)c3ccccc3)cc1N(c1ccc(Cl)cc1)CC2 CHEMBL4176902 IC50 20.0 nM
CC(=O)N1c2ccc(-c3cccs3)cc2[C@H](NC(=O)OC(C)C)C[C@@H]1C CHEMBL4205876 Kd 20.87 nM
Cc1nnn2c1-c1ccc(-c3ccc(N)nc3)cc1N(c1ccc(Cl)cc1)CC2 CHEMBL4168815 IC50 21.0 nM
COc1ccc(Br)cc1S(=O)(=O)Nc1ccc2c(c1)C(=C(C)C)C(=O)N2 CHEMBL4743540 IC50 22.0 nM
Cc1cc(C)cc(Oc2cccc(-c3c(C)nnn3C3CCN(CCN(C)C)CC3)n2)c1 CHEMBL5083660 Kd 22.0 nM
COCc1nn(C2CC2)c2c1[C@@H](c1ccc(Cl)cc1)N(c1cc(N)c3nnc(C)n3c1)C2=O CHEMBL3654321 IC50 23.0 nM
Cc1nn(C2CC2)c2c1C(c1ccc(Cl)cc1)N(c1cc(C)c3nnn(C)c3c1)C2=O CHEMBL3650933 IC50 24.0 nM
Cc1noc(C)c1-c1ccc2c(c1)C(N[C@H](C)CO)(c1ccccc1)C(=O)N2 CHEMBL3910920 IC50 24.0 nM
Cc1nnn2c1-c1ccc(C#N)cc1N(c1ccc(Cl)cc1)CC2 CHEMBL4173105 IC50 24.0 nM
CN(C)CCN1CCN(c2nc(NCc3cccc(Cl)c3)c3cc(-c4ccc(=O)n(C)c4)ccc3n2)CC1 CHEMBL4288569 Kd 24.0 nM
Cc1nn(C2CCC2)c2c1C(c1ccc(Cl)cc1)N(c1cc(C)c(=O)n(C)c1)C2=O CHEMBL3650940 IC50 25.0 nM
Cc1nnn2c1-c1ccc(-c3cc[nH]n3)cc1N(c1ccc(Cl)cc1)CC2 CHEMBL4177080 IC50 25.0 nM
Cc1nnn2c1-c1ccc(C(=O)NS(=O)(=O)c3ccccc3)cc1N(c1ccc(Cl)cc1)CC2 CHEMBL4174587 IC50 25.0 nM
Cc1nnn2c1-c1ccc(C(=O)NS(C)(=O)=O)cc1N(c1ccc(Cl)cc1)CC2 CHEMBL4167362 IC50 25.0 nM
Cc1nnn2c1-c1ccccc1N(c1ccc(Cl)cc1)C[C@H]2C CHEMBL4170756 IC50 25.0 nM
CC(C)=C1C(=O)Nc2ccc(NS(=O)(=O)c3ccccc3Br)cc21 CHEMBL4798353 IC50 25.0 nM
CCNC(=O)C[C@@H]1N=C(c2ccc(Cl)cc2)c2cc(OC)ccc2-n2c(C)nnc21 CHEMBL1232461 Kd 25.0 nM
CCc1nn(C2CC2)c2c1C(c1ccc(Cl)cc1)N(c1cc(C)c(=O)n(C)c1)C2=O CHEMBL3650918 IC50 26.0 nM
COc1ncccc1-n1nc(C)c2c1C(=O)N(c1cc(C)c3nnn(C)c3n1)C2c1ccc(Cl)cc1 CHEMBL3650954 IC50 27.0 nM
Cc1[nH]c(-c2cc(S(C)(=O)=O)ccc2Oc2ccc(F)cc2F)c2c1C(=O)NCC2 CHEMBL3786012 Ki 27.0 nM
Cc1[nH]c(C(=O)Nc2cc(S(=O)(=O)N3CCOCC3)ccc2OCCCCCCCC(=O)NO)c2c1C(=O)CCCC2 CHEMBL5083849 Kd 27.0 nM
Cc1cc2n3c(c[nH]c(=O)c13)CN(C(=O)c1ccc3ccccc3c1)c1ccc(CS(C)(=O)=O)cc1-2 CHEMBL5437856 IC50 27.5 nM
Cc1nn(C2CC2)c2c1[C@@H](c1ccc(Cl)cc1F)N(c1cc(C)c3nnc(C)n3c1)C2=O CHEMBL3654313 IC50 28.0 nM
COc1ncc(-n2nc(C)c3c2C(=O)N(c2cc(C)c(=O)n(C)c2)[C@@H]3c2ccc(Cl)cc2)c(OC)n1 CHEMBL3650945 IC50 28.0 nM
Cc1nn(-c2ccnn2C)c2c1C(c1ccc(Cl)cc1)N(c1cc(C)c3nnc(C)n3c1)C2=O CHEMBL3650937 IC50 28.0 nM
Cc1ccc(-c2ccc3c(c2)N(c2ccc(Cl)cc2)CCn2nnc(C)c2-3)cn1 CHEMBL4173305 IC50 28.0 nM
Cc1nn(C2CC2)c2c1C(c1ccc(Cl)cc1)N(c1cc(C)c3nnc(C)n3c1)C2=O CHEMBL3650938 IC50 29.0 nM
Cc1nnc2n1-c1ccccc1C(c1ccccc1)=N[C@H]2NC(=O)OCc1ccccc1 CHEMBL1738926 IC50 29.9 nM
COc1ncccc1-n1nc(C)c2c1C(=O)N(c1cc(C)c(=O)n(C)c1)[C@@H]2c1ccc(Cl)cc1 CHEMBL3650973 IC50 30.0 nM
CCc1nn(C2CC2)c2c1C(c1ccc(Cl)cc1)N(c1cc(C)c3nnc(C)n3c1)C2=O CHEMBL3650919 IC50 31.0 nM
CCC(C)n1ccc2c(C(=O)NCc3c(C)cc(C)[nH]c3=O)cc(-c3cn(C)c(=O)c4[nH]ccc34)cc21 CHEMBL5434556 IC50 31.0 nM
CC(=O)N1c2ccc(-c3ccc(NC(=O)CCCCCCC(=O)NO)cc3)cc2[C@H](NC(=O)OC(C)C)C[C@@H]1C CHEMBL3220922 Kd(app) 32.0 nM
Cc1nn(-c2ccnn2C)c2c1[C@@H](c1ccc(Cl)cc1)N(c1cc(C)c3nnc(C)n3c1)C2=O CHEMBL3650970 IC50 32.0 nM
COc1ncccc1-n1nc(C)c2c1C(=O)N(c1cc(C)c3nnc(C)n3n1)C2c1ccc(Cl)cc1 CHEMBL3650956 IC50 32.0 nM
Cc1noc(C)c1-c1ccc2c(c1)C(NC[C@@H](C)O)(C1CCCCC1)C(=O)N2 CHEMBL3910409 IC50 32.0 nM
CC(=O)N1c2ccc(C3=CCNCC3)cc2N(Cc2ccccc2CO)C[C@@H]1C1CC1 CHEMBL4218735 pKd 32.36 nM
CNc1cc(N2C(=O)c3c(c(C)nn3C3CC3)[C@H]2c2ccc(Cl)cc2)nn2c(C)nnc12 CHEMBL3654320 IC50 33.0 nM
Cc1cc(N2C(=O)c3c(c(C4CC4)nn3-c3ccnn3C)C2c2ccc(Cl)cc2)cn2c(C)nnc12 CHEMBL3650962 IC50 34.0 nM
Cc1nnn2c1-c1ccccc1N(c1ccc(Cl)cc1)C[C@@H]2C CHEMBL4159455 IC50 34.0 nM
Cc1nn(-c2ccnn2C)c2c1C(c1ccc(Cl)cc1)N(c1cc(C)c3nnc(C)n3n1)C2=O CHEMBL3650959 IC50 35.0 nM
Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)NCCOCCOCCNC(=O)OC(C)(C)C)c1nnc(C)n1-2 CHEMBL4436481 IC50 35.0 nM
CC(=O)Nc1c(F)cc(C(=O)N[C@H]2CC[C@H](O)CC2)cc1O[C@@H](C)c1ccccc1 CHEMBL4636881 Kd 35.0 nM
CC(=O)N1c2ccc(-c3ccc[nH]3)cc2[C@H](NC(=O)OC(C)C)C[C@@H]1C CHEMBL4202664 Kd 35.86 nM
Cc1nn(C(=O)N(C)C)c2c1C(c1ccc(Cl)cc1)N(c1cc(C)c3nnc(C)n3c1)C2=O CHEMBL3654326 IC50 36.0 nM
CCn1nc(C)c2c1C(=O)N(c1cc(C)c3nnc(C)n3c1)C2c1ccc(Cl)cc1 CHEMBL3650961 IC50 36.0 nM
CCc1nn(C2CC2)c2c1C(c1ccc(Cl)cc1)N(c1cc(OC)c3nnc(C)n3c1)C2=O CHEMBL3650932 IC50 37.0 nM
CCc1c2c(nn1C1CC1)C(=O)N(c1cc(C)c(=O)n(C)c1)C2c1ccc(Cl)cc1 CHEMBL3650917 IC50 37.0 nM
Cc1nnn2c1-c1ccc(C(=O)NCc3ccccc3)cc1N(c1ccc(Cl)cc1)CC2 CHEMBL4166286 IC50 37.0 nM
Cc1nnn2c1-c1ccc(-c3cnc(N)nc3)cc1N(c1ccc(Cl)cc1)CC2 CHEMBL4176672 IC50 38.0 nM
COCc1nn(C2CC2)c2c1[C@@H](c1ccc(Cl)cc1)N(c1cc(C)c(=O)n(C)c1)C2=O CHEMBL3654290 IC50 39.0 nM
Cc1nnn2c1-c1ccccc1N(c1ccccc1)CC2 CHEMBL4164698 IC50 39.0 nM
COc1cc2c(cc1-c1c(C)noc1C)ncc1[nH]c(=O)n(C(C)c3ccccc3)c12 CHEMBL2017287 Kd 39.0 nM
Cc1nnc2n1-c1sc(C#Cc3cnn(C4CN(c5cccc6c5C(=O)N(C5CCC(=O)NC5=O)C6=O)C4)c3)c(Cc3ccccc3)c1COC2 CHEMBL5409305 Kd 39.0 nM
Cc1nn(C(C)C)c2c1[C@@H](c1ccc(Cl)cc1F)N(c1cc(C)c3nnc(C)n3c1)C2=O CHEMBL3654312 IC50 40.0 nM
Cc1cc(N2C(=O)c3c(c(C4CC4)nn3C)C2c2ccc(Cl)cc2)cn2c(C)nnc12 CHEMBL3650974 IC50 40.0 nM
Cc1nnn2c1-c1ccc(CO)cc1N(c1ccc(Cl)cc1)CC2 CHEMBL4166455 IC50 40.0 nM
COc1ncccc1-n1nc(C)c2c1C(=O)N(c1cc(C)c(=O)n(C)c1)C2c1ccc(Cl)cc1 CHEMBL3650920 IC50 41.0 nM
Cc1nn(C2CC2)c2c1[C@@H](c1ccc(F)cc1F)N(c1cc(C)c3nnc(C)n3c1)C2=O CHEMBL3654311 IC50 41.0 nM
Cc1nn(C[C@H](O)C(F)(F)F)c2c1[C@@H](c1ccc(Cl)cc1)N(c1cc(C)c3nnc(C)n3c1)C2=O CHEMBL3654325 IC50 42.0 nM
COc1ncc(-n2nc3c(c2C(C)C)C(c2ccc(Cl)cc2)N(c2cc(C)c4nnc(C)n4c2)C3=O)c(OC)n1 CHEMBL3650916 IC50 43.0 nM
COc1ncccc1-n1nc(C)c2c1C(=O)N(c1cc(C)c3nnc(C)n3c1)C2c1ccc(Cl)cc1 CHEMBL3650946 IC50 43.0 nM
Cc1nnn2c1-c1ccccc1N(c1ccc(Cl)cc1)CC2 CHEMBL4169877 IC50 43.0 nM
Cc1nnn2c1-c1ccccc1N(Cc1cccc(Br)c1)CC2 CHEMBL4174918 IC50 44.0 nM
Cc1nnn2c1-c1ccc(C(=O)NC(c3ccccc3)c3ccccc3)cc1N(c1ccc(Cl)cc1)CC2 CHEMBL4166671 IC50 44.0 nM
Cc1cc(N2C(=O)c3nn(C4CC4)c(C)c3C2c2ccc(Cl)cc2)cn2c(C)nnc12 CHEMBL3650939 IC50 45.0 nM
COC(=O)CC1N=C(c2cccc3[nH]ccc23)c2cc(OC)ccc2-n2c(C)nnc21 CHEMBL3770576 Kd 45.0 nM
Cc1nnn2c1-c1ccccc1N(c1ccc(Cl)cc1)CC2CCO CHEMBL4162818 IC50 45.0 nM
Cc1noc(C)c1-c1ccc2nc(-c3cnn(CC(C)(C)O)c3)nc(N3CCOC[C@@H]3c3ccccc3)c2c1 CHEMBL4749664 Kd 45.0 nM
Cc1cc(N2C(=O)c3c(c(CO)nn3C3CC3)C2c2ccc(Cl)cc2)cn2c(C)nnc12 CHEMBL3650976 IC50 46.0 nM
COc1ncccc1-n1nc(C)c2c1C(=O)N(c1cc(C)c3nnc(C)n3c1)C2c1ccc(Cl)cc1F CHEMBL3654307 IC50 47.0 nM
CC(=O)N1c2ccc(-c3ccco3)cc2[C@H](NC(=O)OC(C)C)C[C@@H]1C CHEMBL4209110 Kd 47.0 nM
Cc1cc(N2C(=O)c3nn(C4CC4)c(C)c3[C@H]2c2ccc(Cl)cc2)cn(C)c1=O CHEMBL3650874 IC50 48.0 nM
CCn1nc2c(c1C)C(c1ccc(Cl)cc1)N(c1cc(C)c3nnc(C)n3c1)C2=O CHEMBL3650960 IC50 48.0 nM
CC(C)n1ncc2c1C(=O)N(c1cc(Cl)c(=O)n(C)c1)C2c1ccc(Cl)cc1 CHEMBL3650890 IC50 49.0 nM
Cc1nnn2c1-c1ccc(C(=O)O)cc1N(c1ccc(Cl)cc1)CC2 CHEMBL4166861 IC50 50.0 nM
Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)NCCc1c[nH]c3ccccc13)c1nnc(C)n1-2 CHEMBL5398000 IC50 50.0 nM
CCNC(=O)c1cc(Cc2cccc3[nH]ccc23)nc(-c2cn(C)nn2)c1 CHEMBL4856853 pIC50 50.12 nM
CNC(=O)c1cc(C(=O)N[C@H]2CC[C@H](O)CC2)c([C@@H](C)c2ccccc2)o1 CHEMBL4865767 pIC50 50.12 nM
CCOC(=O)Nc1cc(-c2ccc(C)c(NS(C)(=O)=O)c2)nn2c(C)nnc12 CHEMBL3133807 Kd 50.3 nM
CCc1nn(CCOC)c2c1C(c1ccc(Cl)cc1)N(c1cc(C)c(=O)n(C)c1)C2=O CHEMBL3650934 IC50 52.0 nM
Cc1noc(C)c1-c1ccc2c(c1)C(O)(C1CCCCC1=O)C(=O)N2 CHEMBL3929288 IC50 52.0 nM
COC(=O)c1ccc2c(c1)N(c1ccc(Cl)cc1)CCn1nnc(C)c1-2 CHEMBL4174764 IC50 52.0 nM
COCc1nn(C2CC2)c2c1C(c1ccc(Cl)cc1)N(c1cc(C)c3nnc(C)n3c1)C2=O CHEMBL3650975 IC50 53.0 nM
CCn1nc(C)c2c1C(=O)N(c1cc(C)c3nnc(C)n3c1)[C@@H]2c1ccc(Cl)cc1F CHEMBL3654315 IC50 53.0 nM
Cc1noc(C)c1-c1ccc2c(c1)C(N)(c1ccccc1)C(=O)N2 CHEMBL3955162 IC50 55.0 nM
Cc1cc(N2C(=O)c3c(cnn3C(C)C)C2c2ccc(Cl)cc2)cn(C)c1=O CHEMBL3650888 IC50 57.0 nM
CNC(=O)c1ncc2c(n1)[nH]c1cc(-c3c(C)noc3C)c(OC)cc12 CHEMBL4228904 Ki 57.3 nM
CCOC(=O)N1CC(n2nc(C)c3c2C(=O)N(c2cc(C)c4nnc(C)n4c2)C3c2ccc(Cl)cc2)C1 CHEMBL3654285 IC50 59.0 nM
CCc1c2c(nn1CCO)C(=O)N(c1cc(C)c3onc(C)c3c1)C2c1ccc(Cl)cc1 CHEMBL3650928 IC50 59.0 nM
Cc1cc(N2C(=O)c3c(c(C(F)(F)F)nn3C3CC3)C2c2ccc(Cl)cc2)cn(C)c1=O CHEMBL3650896 IC50 60.0 nM
COc1ncccc1-n1nc(C)c2c1C(=O)N(c1cc(Cl)c(=O)n(C)c1)C2c1ccc(Cl)cc1 CHEMBL3650921 IC50 60.0 nM
CCc1nn(-c2ccnn2C)c2c1C(c1ccc(Cl)cc1)N(c1cc(C)c(=O)n(C)c1)C2=O CHEMBL3650936 IC50 60.0 nM
COc1ncc(-n2nc3c(c2C(C)C)[C@@H](c2ccc(Cl)cc2)N(c2cc(C)c4onc(C)c4c2)C3=O)c(OC)n1 CHEMBL3650911 IC50 60.0 nM
CCn1nc(C)c2c1C(=O)N(c1cc(C)c3nnc(C)n3c1)C2c1ccc(F)cc1F CHEMBL3654304 IC50 62.0 nM
Cc1nn(C2CC2)c2c1C(c1ccc(OC(F)(F)F)cc1)N(c1cc(C)c(=O)n(C)c1)C2=O CHEMBL3650941 IC50 63.0 nM
COc1ncc(-n2nc(C)c3c2C(=O)N(c2cc(C)c(=O)n(C)c2)C3c2ccc(Cl)cc2)c(OC)n1 CHEMBL3650902 IC50 63.0 nM
CNC(=O)c1cc(C(=O)NC2CC2)cn(Cc2cccc3[nH]ccc23)c1=O CHEMBL4648431 pIC50 63.1 nM
Cc1nn(C2CC2)c2c1C(c1ccc(Cl)cc1F)N(c1cc(C)c3nnc(C)n3c1)C2=O CHEMBL3654301 IC50 68.0 nM
CCn1nc(C)c2c1C(=O)N(c1cc(C)c3nnc(C)n3c1)[C@@H]2c1ccc(F)cc1F CHEMBL3654314 IC50 69.0 nM
COc1ncc(-n2nc3c(c2C)C(c2ccc(Cl)cc2)N(c2cc(Cl)c(=O)n(C)c2)C3=O)c(OC)n1 CHEMBL3650905 IC50 69.0 nM
Cc1nn(-c2ccnn2C)c2c1C(c1ccc(Cl)cc1)N(c1cc(C)c(=O)n(C)c1)C2=O CHEMBL3650923 IC50 71.0 nM
Cc1nn(C(C)C)c2c1C(c1ccc(Cl)cc1F)N(c1cc(C)c3nnc(C)n3c1)C2=O CHEMBL3654291 IC50 71.0 nM
CCn1nc(C)c2c1C(=O)N(c1cc(C)c3nnc(C)n3c1)C2c1ccc(Cl)cc1F CHEMBL3654308 IC50 71.0 nM
CN1C(=O)c2c(F)cccc2Oc2cc(N[C@H]3CC[C@H](O)CC3)ncc21 CHEMBL4763016 Kd 71.0 nM
CC(=O)N1CCc2c(sc3nc(SCC(=O)Nc4cccnc4C)n(Cc4ccco4)c(=O)c23)C1 CHEMBL5082786 IC50 71.0 nM
Cc1cc(N2C(=O)c3nn(C(C)C)c(C)c3C2c2ccc(F)cc2F)cn2c(C)nnc12 CHEMBL3654298 IC50 72.0 nM
CCc1nn(CCOC)c2c1C(c1ccc(Cl)cc1)N(c1cc(C)c3nnc(C)n3c1)C2=O CHEMBL3650935 IC50 72.0 nM
Cc1nn(C2CC2)c2c1C(c1ccc(Cl)cc1)N(c1ccc3nnn(C)c3n1)C2=O CHEMBL3650947 IC50 72.0 nM
Cc1cc(N2C(=O)c3nn(C(C)C)cc3C2c2ccc(Cl)cc2)cn(C)c1=O CHEMBL3650892 IC50 75.0 nM
Cc1nn(C2CN(C)C2)c2c1C(c1ccc(Cl)cc1)N(c1cc(C)c3nnc(C)n3c1)C2=O CHEMBL3654286 IC50 77.0 nM
Cc1nn(-c2ccnn2C)c2c1[C@@H](c1ccc(Cl)cc1)N(c1cc(C)c(=O)n(C)c1)C2=O CHEMBL3650965 IC50 78.0 nM
Cn1cc(N2C(=O)c3nn(C4CC4)cc3C2c2ccc(Cl)cc2)cc(Cl)c1=O CHEMBL3650889 IC50 78.0 nM
Cc1c2c(nn1C1CC1)C(=O)N(c1cc(Cl)c(=O)n(C)c1)[C@@H]2c1ccc(Cl)cc1 CHEMBL3650872 IC50 78.0 nM
Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)NCCOCCOCCNC(=O)CS(=O)(=O)O)c1nnc(C)n1-2 CHEMBL4576135 IC50 78.0 nM
COc1ncccc1-n1nc(C)c2c1C(=O)N(c1cc(C)c3nnc(C)n3c1)C2c1ccc(F)cc1F CHEMBL3654296 IC50 79.0 nM
CCc1nn(CCO)c2c1C(c1ccc(Cl)cc1)N(c1cc(C)c(=O)n(C)c1)C2=O CHEMBL3650926 IC50 79.0 nM
CCOC(=O)N1CC(n2nc(C)c3c2C(=O)N(c2cc(C)c(=O)n(C)c2)C3c2ccc(Cl)cc2)C1 CHEMBL3654284 IC50 80.0 nM
COCc1nn(C2CC2)c2c1C(c1ccc(Cl)cc1)N(c1cc(C)c(=O)n(C)c1)C2=O CHEMBL3654263 IC50 81.0 nM
CNc1cc(N2C(=O)c3c(c(C)nn3C3CC3)C2c2ccc(Cl)cc2)nn2c(C)nnc12 CHEMBL3650958 IC50 86.0 nM
Cc1nn(C2CC2)c2c1C(c1ccc(C(F)(F)F)cc1)N(c1cc(C)c(=O)n(C)c1)C2=O CHEMBL3650943 IC50 88.0 nM
Cc1nn(C(C)C)c2c1C(c1ccc(Cl)cc1F)N(c1cc(C)c(=O)n(C)c1)C2=O CHEMBL3654303 IC50 89.0 nM
COc1ncccc1-n1nc2c(c1C)C(c1ccc(Cl)cc1F)N(c1cc(C)c3nnc(C)n3c1)C2=O CHEMBL3654317 IC50 90.0 nM
CC(C)n1cc2c(n1)C(=O)N(c1cc(Cl)c(=O)n(C)c1)C2c1ccc(Cl)cc1 CHEMBL3650893 IC50 91.0 nM
Cc1nn(C2COC2)c2c1C(c1ccc(Cl)cc1)N(c1cc(C)c3nnc(C)n3c1)C2=O CHEMBL3654268 IC50 92.0 nM
Cc1nn(C2CC2)c2c1C(c1ccc(Cl)cc1F)N(c1cc(C)c(=O)n(C)c1)C2=O CHEMBL3654302 IC50 92.0 nM
CC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(-c2scnc2C)cc1)C(C)(C)SCCCCCNC(=O)C[C@@H]1N=C(c2ccc(Cl)cc2)c2c(sc(C)c2C)-n2c(C)nnc21 CHEMBL5281933 Kd 94.0 nM
Cc1cc(N2C(=O)c3c(cnn3C3CC3)C2c2ccc(Cl)cc2)cn(C)c1=O CHEMBL3650886 IC50 95.0 nM
Cc1ncccc1-n1nc(C)c2c1C(=O)N(c1cc(C)c(=O)n(C)c1)C2c1ccc(Cl)cc1 CHEMBL3650930 IC50 97.0 nM
COc1ncc(-n2nc(C)c3c2C(=O)N(c2cc(Cl)c(=O)n(C)c2)C3c2ccc(Cl)cc2)c(OC)n1 CHEMBL3650903 IC50 98.0 nM
Cc1cc(N2C(=O)c3nn(C4CN(C)C4)c(C)c3C2c2ccc(Cl)cc2)cn2c(C)nnc12 CHEMBL3654287 IC50 98.0 nM
Cc1[nH][n+](C2CC2)c2c1C(c1ccc(Cl)cc1)N(c1cc(C)c(=O)n(C)c1)C2=O CHEMBL4110697 IC50 99.0 nM
Cc1c2c(nn1C)C(=O)N(c1cc(Cl)c(=O)n(C)c1)[C@@H]2c1ccc(Cl)cc1 CHEMBL3650860 IC50 100.0 nM
Cc1cc(N2C(=O)c3nn(C)cc3[C@H]2c2ccc(Cl)cc2)cn(C)c1=O CHEMBL3650869 IC50 100.0 nM
Cc1cc(N2C(=O)c3nn(C4CC4)c(C(F)(F)F)c3C2c2ccc(Cl)cc2)cn(C)c1=O CHEMBL3650894 IC50 100.0 nM
Cc1cc(N2C(=O)c3nn(C4CNC4)c(C)c3C2c2ccc(Cl)cc2)cn2c(C)nnc12 CHEMBL3654281 IC50 100.0 nM
CCOc1c2c(nn1C)C(=O)N(c1cc(C)c(=O)n(C)c1)C2c1ccc(Cl)cc1 CHEMBL3650924 IC50 100.0 nM
CC(=O)N1c2ccc(-c3cnc(C(N)=O)nc3)cc2N(Cc2ccccc2CO)C[C@@H]1C1CC1 CHEMBL4213809 pIC50 100.0 nM
COc1nnc2ccc(N3CCC(c4ccc(OCCN5CCN(C)C(=O)[C@H]5C)cc4)CC3)nn12 CHEMBL4078100 pKi 100.0 nM
CC(=O)OC[C@]12CC[C@H]3[C@@H](C[C@H]4O[C@]45CC=CC(=O)[C@]35C)[C@]1(O)CC[C@@]2(O)[C@@](C)(O)[C@H]1CC(C)=C(C)C(=O)O1 CHEMBL3605565 IC50 103.0 nM
CCc1nn(CCO)c2c1C(c1ccc(Cl)cc1)N(c1cc(C)c3onc(C)c3c1)C2=O CHEMBL3650927 IC50 110.0 nM
Cc1nn(C(C)C)c2c1C(c1ccc(F)cc1F)N(c1cc(C)c3nnc(C)n3c1)C2=O CHEMBL3654297 IC50 110.0 nM
Cc1cc2n3c(c[nH]c(=O)c13)CN(C(=O)c1cccc3ccccc13)c1ccc(CS(C)(=O)=O)cc1-2 CHEMBL5440806 IC50 111.0 nM
Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCOCCOCCNC(=O)C[C@@H]2N=C(c3ccc(Cl)cc3)c3c(sc(C)c3C)-n3c(C)nnc32)C(C)(C)C)cc1 CHEMBL4226570 Kd 115.0 nM
CCn1nc2c(c1C)C(c1ccc(F)cc1F)N(c1cc(C)c3nnc(C)n3c1)C2=O CHEMBL3654305 IC50 120.0 nM
Cc1nn(-c2cncn2C)c2c1C(c1ccc(Cl)cc1)N(c1cc(C)c(=O)n(C)c1)C2=O CHEMBL3650931 IC50 120.0 nM
CC(=O)N1CC(n2nc(C)c3c2C(=O)N(c2cc(C)c4nnc(C)n4c2)C3c2ccc(Cl)cc2)C1 CHEMBL3654283 IC50 120.0 nM
Cc1nn(C2CC2)c2c1C(c1ccc(F)cc1F)N(c1cc(C)c3nnc(C)n3c1)C2=O CHEMBL3654299 IC50 120.0 nM
COc1c2c(nn1C)C(=O)N(c1cc(C)c(=O)n(C)c1)C2c1ccc(Cl)cc1 CHEMBL3650925 IC50 120.0 nM
Cc1cc(N2C(=O)c3nn(C(C)C)c(C)c3C2c2ccc(Cl)cc2F)cn2c(C)nnc12 CHEMBL3654292 IC50 120.0 nM
Cc1ncccc1-n1nc2c(c1C)C(c1ccc(Cl)cc1)N(c1cc(C)c(=O)n(C)c1)C2=O CHEMBL3650929 IC50 120.0 nM
CC(=O)N1CCc2c(sc3nc(SCC(=O)Nc4cc(Cl)ccc4C)n(Cc4ccco4)c(=O)c23)C1 CHEMBL5080392 IC50 120.0 nM
Cc1nnc2c(NC3CCN(CC(C)(C)F)CC3)cc(C(=O)N3[C@@H]4c5ccccc5C[C@H]3C(=O)N[C@@H]4C(C)C)nn12 CHEMBL5079885 pKd 125.89 nM
CCc1nn(C)c2c1C(c1ccc(Cl)cc1)N(c1cc(OC)c3nnc(C)n3c1)C2=O CHEMBL3650950 IC50 130.0 nM
Cc1nn(C(C)C)c2c1C(c1ccc(Cl)cc1)N(c1cc(C)c(=O)n(C)c1)C2=O CHEMBL3650912 IC50 130.0 nM
COc1ncc(-n2nc3c(c2C(C)C)C(c2ccc(Cl)cc2)N(c2cc(C)c4onc(C)c4c2)C3=O)c(OC)n1 CHEMBL3639497 IC50 130.0 nM
COc1ncccc1-n1nc2c(c1C)C(c1ccc(F)cc1F)N(c1cc(C)c3nnc(C)n3c1)C2=O CHEMBL3654316 IC50 130.0 nM
Cc1cc(N2C(=O)c3nn(C4CC4)c(C)c3C2c2ccc(Cl)cc2)cn(C)c1=O CHEMBL3650873 IC50 130.0 nM
Cn1cc2c(n1)C(=O)N(c1cc(Cl)c(=O)n(C)c1)[C@@H]2c1ccc(Cl)cc1 CHEMBL3650864 IC50 140.0 nM
CCc1nn(C(=O)N(C)C)c2c1C(c1ccc(Cl)cc1)N(c1cc(C)c(=O)n(C)c1)C2=O CHEMBL3654278 IC50 140.0 nM
Cc1cc(N2C(=O)c3nn(C4COC4)c(C)c3C2c2ccc(Cl)cc2)cn2c(C)nnc12 CHEMBL3654267 IC50 140.0 nM
CCn1nc2c(c1C)C(c1ccc(Cl)cc1F)N(c1cc(C)c3nnc(C)n3c1)C2=O CHEMBL3654309 IC50 140.0 nM
CCn1nc2c(c1C)C(c1ccc(Cl)cc1F)N(c1cc(C)c(=O)n(C)c1)C2=O CHEMBL3654294 IC50 140.0 nM
Cn1cc(N2C(=O)c3c(cnn3C3CC3)C2c2ccc(Cl)cc2)cc(Cl)c1=O CHEMBL3650887 IC50 140.0 nM
Cc1cc(N2C(=O)c3nn(C(=O)N(C)C)c(C)c3[C@H]2c2ccc(Cl)cc2)cn2c(C)nnc12 CHEMBL3654327 IC50 140.0 nM
Cc1nnc2n1-c1sc(C#Cc3cnn(CCNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)c3)c(Cc3ccccc3)c1COC2 CHEMBL5421103 Kd 140.0 nM
Cc1nnn2c1-c1ccc(Cn3cccn3)cc1N(c1ccc(Cl)cc1)CC2 CHEMBL4161952 IC50 147.0 nM
CC(=O)N1c2ccc(-c3ccoc3)cc2[C@H](NC(=O)OC(C)C)C[C@@H]1C CHEMBL4207106 Kd 148.0 nM
Cn1cc2c(n1)C(=O)N(c1cc(Cl)c(=O)n(C)c1)C2c1ccc(Cl)cc1 CHEMBL3650863 IC50 150.0 nM
Cc1nn(C2CNC2)c2c1C(c1ccc(Cl)cc1)N(c1cc(C)c3nnc(C)n3c1)C2=O CHEMBL3654280 IC50 150.0 nM
Cc1nn(C2COC2)c2c1C(c1ccc(Cl)cc1)N(c1cc(C)c(=O)n(C)c1)C2=O CHEMBL3654266 IC50 150.0 nM
Cn1cc(N2C(=O)c3nn(C4CC4)c(C(F)(F)F)c3C2c2ccc(Cl)cc2)cc(Cl)c1=O CHEMBL3650891 IC50 160.0 nM
Cc1cc(N2C(=O)c3nn(C4CN(C)C4)c(C)c3C2c2ccc(Cl)cc2)cn(C)c1=O CHEMBL3654270 IC50 160.0 nM
CC(=O)N1CC(n2nc(C)c3c2C(=O)N(c2cc(C)c(=O)n(C)c2)C3c2ccc(Cl)cc2)C1 CHEMBL3654282 IC50 160.0 nM
CNC(=O)n1nc2c(c1C)C(c1ccc(Cl)cc1)N(c1cc(C)c(=O)n(C)c1)C2=O CHEMBL3654275 IC50 160.0 nM
CCc1nn(-c2cnc(OC)nc2OC)c2c1C(c1ccc(Cl)cc1)N(c1cc(C)c(=O)n(C)c1)C2=O CHEMBL3650909 IC50 160.0 nM
Cc1nn(C(C)C)c2c1C(c1ccc(Cl)cc1)N(c1cc(Cl)c(=O)n(C)c1)C2=O CHEMBL3650915 IC50 160.0 nM
Cn1cc(-c2cc(S(C)(=O)=O)ccc2Oc2ccc(F)cc2F)c2cc[nH]c(=O)c21 CHEMBL4088466 Ki 160.0 nM
Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)NCc1cn(C)nn1)c1nnc(C)n1-2 CHEMBL5420752 IC50 161.0 nM
CC[C@@H]1C(=O)N(C)c2cnc(N(C)c3ccc(-c4nc5c(C(N)=O)cccc5[nH]4)cc3OC)nc2N1C1CCCC1 CHEMBL5084388 IC50 168.0 nM
Cn1cc(N2C(=O)c3c(c(C(F)(F)F)nn3C3CC3)C2c2ccc(Cl)cc2)cc(Cl)c1=O CHEMBL3650895 IC50 170.0 nM
CCc1c(C(=O)Nc2cc(S(=O)(=O)N(CC)CC)ccc2O)[nH]c(C)c1C(C)=O CHEMBL3787231 Kd 170.0 nM
COc1cc2c(cc1-c1c(C)noc1C)[nH]c1ncnc(NCCCCCCC(=O)NO)c12 CHEMBL5405779 IC50 174.0 nM
CNC(=O)n1nc(C)c2c1C(=O)N(c1cc(C)c3nnc(C)n3c1)C2c1ccc(Cl)cc1 CHEMBL3654276 IC50 180.0 nM
Cc1c2c(nn1C1CC1)C(=O)N(c1cc(Cl)c(=O)n(C)c1)C2c1ccc(Cl)cc1 CHEMBL3650870 IC50 180.0 nM
Cc1cc(N2C(=O)c3nn(C)cc3C2c2ccc(Cl)cc2)cn(C)c1=O CHEMBL3650866 IC50 180.0 nM
Cc1nn(C(=O)N(C)C)c2c1C(c1ccc(Cl)cc1)N(c1cc(C)c(=O)n(C)c1)C2=O CHEMBL3654273 IC50 180.0 nM
Cc1cc(N2C(=O)c3nn(C(C)C)c(C)c3C2c2ccc(Cl)cc2)cn(C)c1=O CHEMBL3650913 IC50 180.0 nM
Cc1cc(N2C(=O)c3nn(C(=O)N(C)C)c(C)c3C2c2ccc(Cl)cc2)cn(C)c1=O CHEMBL3654272 IC50 180.0 nM
Cc1ncsc1-c1ccc2c(c1)OCCOCCOC[C@@H](NC(=O)C[C@H]1N=C(c3ccc(Cl)cc3)c3c(sc(C)c3C)-n3c(C)nnc31)COCCOCCOCC(=O)N[C@@H](C(C)(C)C)C(=O)N1C[C@H](O)C[C@H]1C(=O)NC2 CHEMBL5283149 Kd 180.0 nM
Cc1cc(N2C(=O)c3nn(C4COC4)c(C)c3C2c2ccc(Cl)cc2)cn(C)c1=O CHEMBL3654265 IC50 190.0 nM
CNC(=O)n1nc2c(c1C)C(c1ccc(Cl)cc1)N(c1cc(C)c3nnc(C)n3c1)C2=O CHEMBL3654277 IC50 190.0 nM
CC(=O)N1c2ccc(-c3ccc(C(=O)O)cc3)cc2[C@H](Nc2ccc(C)cc2)C[C@@H]1C CHEMBL3353999 pIC50 199.53 nM
Cc1cc(N2C(=O)c3nn(C)c(O)c3C2c2ccc(Cl)cc2)cn(C)c1=O CHEMBL3650922 IC50 200.0 nM
Cc1nnn2c1-c1ccc(C(O)C(F)(F)F)cc1N(c1ccc(Cl)cc1)CC2 CHEMBL4165200 IC50 204.0 nM
COc1cc(OC)c2c(=O)[nH]c(-c3cc(C)c(OCCO)c(C)c3)nc2c1 CHEMBL2393130 Kd 206.0 nM
Cc1[nH]nc2c1C(c1ccc(Cl)cc1)N(c1cc(C)c(=O)n(C)c1)C2=O CHEMBL3650879 IC50 210.0 nM
CCc1nn(CCOCC(F)(F)F)c2c1C(c1ccc(Cl)cc1)N(c1cc(OC)c3nnc(C)n3c1)C2=O CHEMBL3650953 IC50 210.0 nM
COc1ncc(-n2nc3c(c2C(F)(F)F)C(c2ccc(Cl)cc2)N(c2cc(Cl)c(=O)n(C)c2)C3=O)c(OC)n1 CHEMBL3650897 IC50 210.0 nM
Cn1cc(N2C(=O)c3n[nH]cc3C2c2ccc(Cl)cc2)cc(Cl)c1=O CHEMBL3650862 IC50 210.0 nM
Cc1n[nH]c2c1C(c1ccc(F)cc1F)N(c1cc(C)c3nnc(C)n3c1)C2=O CHEMBL3654295 IC50 220.0 nM
CCc1c2c(nn1C(=O)N(C)C)C(=O)N(c1cc(C)c(=O)n(C)c1)C2c1ccc(Cl)cc1 CHEMBL3654279 IC50 220.0 nM
Cc1nn(C2CC2)c2c1C(c1ccc(Cl)cc1)N(c1cc(Cl)c(=O)n(C)c1)C2=O CHEMBL3650877 IC50 230.0 nM
COc1ccc(S(=O)(=O)n2ccc(/C=C/C(=O)NO)c2)cc1NC(=O)c1[nH]c(C)c2c1CCCCC2=O CHEMBL5080049 Kd 230.0 nM
Cc1c2c(nn1C(C)C)C(=O)N(c1cc(Cl)c(=O)n(C)c1)C2c1ccc(Cl)cc1 CHEMBL3650914 IC50 240.0 nM
C[C@H](Oc1ccc(C(=O)NC2CC2)cc1-c1cn(C)nn1)c1ccccn1 CHEMBL4867703 pIC50 251.19 nM
CNC(=O)c1cc(C(=O)N[C@H]2CC[C@H](O)CC2)n([C@@H](C)c2ccccc2)n1 CHEMBL4854042 pIC50 251.19 nM
Cc1nn(C)c2c1C(c1ccc(Cl)cc1)N(c1cc(C)c(=O)n(C)c1)C2=O CHEMBL3650906 IC50 270.0 nM
Cc1c2c(nn1C)C(=O)N(c1ccc3nnc(C)n3c1)C2c1ccc(Cl)cc1 CHEMBL3650878 IC50 270.0 nM
Cc1[nH]nc2c1C(c1ccc(Cl)cc1F)N(c1cc(C)c(=O)n(C)c1)C2=O CHEMBL3654319 IC50 270.0 nM
Cc1ccc(C(C)C)cc1Oc1nccc(-c2c(-c3ccc(C(F)(F)F)cc3)ncn2C2CCNCC2)n1 CHEMBL5084290 IC50 280.0 nM
Cc1cc(N2C(=O)c3nn(C)c(C)c3C2c2ccc(Cl)cc2)cn(C)c1=O CHEMBL3650880 IC50 320.0 nM
CNC(=O)n1nc(C)c2c1C(=O)N(c1cc(C)c(=O)n(C)c1)C2c1ccc(Cl)cc1 CHEMBL3654274 IC50 330.0 nM
Cc1c2c(nn1C)C(=O)N(c1cc(Cl)c(=O)n(C)c1)C2c1ccc(Cl)cc1 CHEMBL3650859 IC50 350.0 nM
COc1cc(OC)c2c(=O)[nH]c(-c3ccc(OCCOc4ccccc4C(N)=O)cc3)nc2c1 CHEMBL5205994 IC50 379.0 nM
Cc1noc(C)c1-c1ccc2c(c1)C(O)(C1CCOCC1)C(=O)N2 CHEMBL3963603 IC50 380.0 nM
CO[C@H]1CC[C@H](n2c([C@@H]3CCCC(=O)N3c3ccc(F)c(F)c3)nc3cc(-c4c(C)noc4C)ccc32)CC1 CHEMBL4785363 Kd 390.0 nM
COc1cc2c(cc1-c1c(C)noc1C)ncc1[nH]c(=O)n([C@H](C)c3ccccc3)c12 CHEMBL2017288 pIC50 398.11 nM
CNC(=O)CN(CC(c1ccccc1)c1ccccc1)C(=O)c1cc(C)c(OC)c(C)c1 CHEMBL4878540 pIC50 398.11 nM
Cc1nn(C2CN(C)C2)c2c1C(c1ccc(Cl)cc1)N(c1cc(C)c(=O)n(C)c1)C2=O CHEMBL3654271 IC50 420.0 nM
COc1ncc(-n2nc3c(c2C(C)C)C(c2ccc(Cl)cc2)N(c2ccc4onc(C)c4c2)C3=O)c(OC)n1 CHEMBL3650904 IC50 480.0 nM
Cc1ccc(-c2c(C)noc2C)cc1S(=O)(=O)NC1CCCC1 CHEMBL2181721 IC50 500.0 nM
COc1cc2c(cc1-c1c(C)noc1C)ncc1[nH]c(=O)n(Cc3ccccc3)c12 CHEMBL2017285 pIC50 501.19 nM
COc1cc2c(cc1-c1c(C)noc1C)ncc1[nH]c(=O)n(-c3ccccc3C(C)(C)C)c12 CHEMBL2017283 pIC50 501.19 nM
COc1cc2c(Nc3ccccc3F)c(C(N)=O)cnc2cc1-c1c(C)noc1C CHEMBL2017273 pIC50 501.19 nM
CC(=O)N1c2ccc(-c3ccc(CN4CCCCC4)cc3)cc2[C@H](Nc2ccccc2)C[C@@H]1C CHEMBL3353992 pIC50 501.19 nM
COC(=O)c1ccc(-c2ccc3c(c2)[C@H](Nc2ccc(C(C)(C)C)cc2)C[C@H](C)N3C(C)=O)cc1 CHEMBL3353996 pIC50 501.19 nM
Cc1nn(C)c2c1C(c1ccc(Cl)cc1)N(c1cc(Cl)c(=O)n(C)c1)C2=O CHEMBL3650907 IC50 560.0 nM
Cc1c2c(nn1C)C(=O)N(c1ccc(=O)n(C)c1)C2c1ccc(Cl)cc1 CHEMBL3650856 IC50 580.0 nM
COc1nccc(-n2nc(C)c3c2C(=O)N(c2cc(C)c(=O)n(C)c2)C3c2ccc(Cl)cc2)n1 CHEMBL3650908 IC50 610.0 nM
CC(=O)N1c2ccc(-c3ccc(C(=O)O)cc3)cc2[C@H](Nc2ccccc2)C[C@@H]1C CHEMBL3352833 pIC50 630.96 nM
COc1cccc(N[C@@H]2C[C@H](C)N(C(C)=O)c3ccc(-c4ccc(C(=O)O)cc4)cc32)c1 CHEMBL3354003 pIC50 630.96 nM
COc1ccccc1N[C@@H]1C[C@H](C)N(C(C)=O)c2ccc(-c3ccc(C(=O)O)cc3)cc21 CHEMBL3354004 pIC50 630.96 nM
Cc1cncc(-c2ccc(N[C@@H]3CCNC[C@H]3OCC3CCS(=O)(=O)CC3)c3[nH]c(=O)c(C)cc23)c1 CHEMBL3590405 pKd 630.96 nM
Cc1nn(C2CC2)c2c1C(c1cccc(C(F)(F)F)c1)N(c1cc(C)c(=O)n(C)c1)C2=O CHEMBL3650942 IC50 660.0 nM
Cc1c2c(nn1C)C(=O)N(c1cc(F)c(=O)n(C)c1)C2c1ccc(Cl)cc1 CHEMBL3650883 IC50 690.0 nM
CN1C=C(c2ccc3ccn(Cc4ccccn4)c3c2)C2C=CNC2C1=O CHEMBL5205457 IC50 718.0 nM
Cc1[nH]nc2c1C(c1ccc(Cl)cc1)N(c1cc(Cl)c(=O)n(C)c1)C2=O CHEMBL3650858 IC50 730.0 nM
O=C(Nc1ccc(C(F)(F)F)cc1)Nc1ccc(S(=O)(=O)N2CCC[C@H]2CN2CCC(O)CC2)cc1 CHEMBL5076336 IC50 742.0 nM
Cc1cc(/N=N/c2ccc(S(=O)(=O)NC3CCCC3)cc2)c(N)cc1O CHEMBL4159382 IC50 772.0 nM
COc1cc(OC)c2c(=O)cc(-c3cc(C)c(OC[C@H](O)CN4CCCCC4)c(C)c3)oc2c1 CHEMBL4455209 Kd 791.0 nM
Cc1noc(C)c1-c1ccc2c(Nc3ccccc3C(C)(C)C)c(C(=O)O)cnc2c1 CHEMBL2017269 pIC50 794.33 nM
COc1ccc2c(c1)C(c1ccccc1)=NC(NC(=O)OCc1ccccc1)c1nnc(C)n1-2 CHEMBL2430892 pIC50 794.33 nM
CC(=O)N1c2ccc(-c3ccccc3)cc2[C@H](Nc2ccccc2)C[C@@H]1C CHEMBL3353984 pIC50 794.33 nM
CC(=O)N1c2ccc(-c3ccc(CO)cc3)cc2[C@H](Nc2ccccc2)C[C@@H]1C CHEMBL3353989 pIC50 794.33 nM
CC(=O)N1c2ccc(-c3ccc(CN4CCOCC4)cc3)cc2[C@H](Nc2ccccc2)C[C@@H]1C CHEMBL3353990 pIC50 794.33 nM
CC(=O)N1c2ccc(-c3cccc(C(=O)O)c3)cc2[C@H](Nc2ccc(Cl)cc2)C[C@@H]1C CHEMBL3354006 pIC50 794.33 nM
CC(=O)N1c2ccc(-c3ccc(C(N)=O)cc3)cc2[C@H](Nc2ccc(Cl)cc2)C[C@@H]1C CHEMBL3354008 pIC50 794.33 nM
CCN(C1CCCC1)S(=O)(=O)c1cc(-c2c(C)noc2C)ccc1OC CHEMBL2181704 IC50 800.0 nM
COc1ccc(-c2c(C)noc2C)cc1S(=O)(=O)N(C)C1CCCC1 CHEMBL2181703 IC50 800.0 nM
Cc1cc(/N=N/c2ccc3c(c2)CCC(=O)N3)c(N)cc1O CHEMBL4176038 IC50 803.0 nM
O=C(Nc1ccc(C(F)(F)F)cc1)Nc1ccc(S(=O)(=O)N2CCC[C@H]2CN2CCOCC2)cc1 CHEMBL5090401 IC50 835.0 nM
COc1ccn2c(C(C)=O)cc(C(=O)Nc3cc(C(C)O)cc(-c4cnn(C5CC5)c4)c3F)c2c1 CHEMBL5179520 Kd 840.0 nM
COc1cc(OC)c2c(=O)cc(-c3cc(C)c(OC[C@H](O)CN4CCN(C)CC4)c(C)c3)oc2c1 CHEMBL4557050 Kd 886.0 nM
Cc1ccc(-c2c(C)noc2C)cc1S(=O)(=O)NC1CCCCC1 CHEMBL2181723 IC50 900.0 nM
Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)NCCOCCOCCNC(=O)C1C(C(=O)O)C(C(=O)O)C1C(=O)O)c1nnc(C)n1-2 CHEMBL4474387 IC50 997.0 nM
COc1cc2c(Nc3cccc4cccnc34)c(C(N)=O)cnc2cc1-c1c(C)noc1C CHEMBL2017281 pIC50 1000.0 nM
CC(=O)N1c2ccc(-c3ccc(C#N)cc3)cc2[C@H](Nc2ccccc2)C[C@@H]1C CHEMBL3353985 pIC50 1000.0 nM
CC(=O)N1c2ccc(-c3ccc(C(=O)O)cc3)cc2[C@H](Nc2ccc(S(C)(=O)=O)cc2)C[C@@H]1C CHEMBL3353997 pIC50 1000.0 nM
CC(=O)N1c2ccc(-c3ccc(CN4CCCCC4)cc3)cc2[C@H](Nc2ccc(Cl)cc2)C[C@@H]1C CHEMBL3354005 pIC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3cn(CC4CCS(=O)(=O)CC4)nc3C2=O)COc2ccccc21 CHEMBL4097778 pIC50 1000.0 nM