CCn1nc(C2CC2)cc1Nc1nc(C(=O)NC)nc2[nH]c3cc(-c4c(C)noc4C)c(OC)cc3c12 CHEMBL4228445 Ki 0.18 nM
CC(=O)N1c2ccc(-c3ccc(C(=O)O)cc3)cc2[C@H](Nc2ccc(Cl)cc2)C[C@@H]1C CHEMBL2177300 pIC50 0.2512 nM
CCS(=O)(=O)Nc1cc(-c2cn(C)c3c(=O)[nH]ccc23)cc2c1ccn2C(C)(c1ccccn1)c1ccccn1 CHEMBL4648912 Kd 0.27 nM
COc1cc2c(cc1-c1c(C)noc1C)[nH]c1nc(C)nc(Nc3cc(C4CC4)nn3C)c12 CHEMBL4173488 Kd 0.49 nM
Cc1ccc2ncccc2c1-c1cc(-c2c(C)noc2C)cc2nc(C3CC3)[nH]c12 CHEMBL3926851 Kd 0.65 nM
COc1cc2c(cc1-c1c(C)noc1C)[nH]c1nc(C)nc(-c3ccnc4ccccc34)c12 CHEMBL4171228 Kd 0.69 nM
CCNC(=O)c1cc2c(-c3cc(C(C)(C)O)ccc3Oc3c(C)cc(F)cc3C)cn(C)c(=O)c2[nH]1 CHEMBL4297454 IC50 0.88 nM
CCS(=O)(=O)Cc1cnc(Oc2ccc(F)cc2F)c(-c2cc(C)c3c(=O)[nH]ccn23)c1 CHEMBL4440098 Kd 1.0 nM
Cc1nnn(C)c1-c1cnc2c3ccc(C(C)(C)O)cc3n([C@H](c3ccccc3)C3CCOCC3)c2c1 CHEMBL4297458 IC50 1.1 nM
CNC(=O)c1cc(C(=O)N[C@H]2[C@@H]3C[C@@H](O)C[C@@H]32)cc2c1OC[C@@]2(C)c1ccccc1 CHEMBL4869149 pIC50 1.259 nM
[2H]C([2H])([2H])c1nnn(C)c1-c1cnc2c3cc(F)c(C(C)(C)O)cc3n([C@H](c3ccccc3)C3CCOCC3)c2c1 CHEMBL4859923 IC50 1.6 nM
Cc1noc(C)c1-c1cnc2c3ccc(C(C)(C)O)cc3n([C@H](c3ccccc3)C3CCOCC3)c2c1 CHEMBL5087175 IC50 1.9 nM
Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@H](CC(=O)OC(C)(C)C)c1nnc(C)n1-2 CHEMBL3220211 K 1.95 nM
Cc1nnc2n1-c1ccc(-c3ccc(CNCCCCCCc4cccc5c4CN(C4CCC(=O)NC4=O)C5=O)cc3)cc1C(Nc1ccc(Cl)cc1)CC2 CHEMBL5394107 Ki 2.16 nM
Cc1nnc2n1-c1ccc(-c3ccc(CNCCCCc4cccc5c4CN(C4CCC(=O)N(C)C4=O)C5=O)cc3)cc1C(Nc1ccc(Cl)cc1)CC2 CHEMBL5435922 Ki 2.24 nM
Cc1nnc2n1-c1ccc(-c3ccc(CNCCCCCCCc4cccc5c4CN(C4CCC(=O)NC4=O)C5=O)cc3)cc1C(Nc1ccc(Cl)cc1)CC2 CHEMBL5423636 Ki 2.26 nM
Cc1nnc2n1-c1ccc(-c3ccc(CNCCCCc4cccc5c4CN(C4CCC(=O)NC4=O)C5=O)cc3)cc1C(Nc1ccc(Cl)cc1)CC2 CHEMBL5418787 Ki 2.45 nM
Cc1nnc2n1-c1ccc(-c3ccc(CNCCCc4cccc5c4CN(C4CCC(=O)NC4=O)C5=O)cc3)cc1C(Nc1ccc(Cl)cc1)CC2 CHEMBL5437043 Ki 2.46 nM
Cc1nnc2n1-c1sc(C#Cc3cnn(C)c3)c(Cc3ccccc3)c1COC2 CHEMBL4555209 Ki 2.5 nM
Cc1nnc2n1-c1ccc(-c3cnn(C)c3)cc1[C@H](Nc1ccc(Cl)cc1)CC2 CHEMBL4528047 Kd 2.6 nM
Cc1nnc2n1-c1ccc(-c3ccc(CN(C)CCCCc4cccc5c4CN(C4CCC(=O)NC4=O)C5=O)cc3)cc1C(Nc1ccc(Cl)cc1)CC2 CHEMBL5432216 Ki 2.8 nM
Cc1nnc2n1-c1ccc(-c3ccc(N)nc3)cc1N(c1ccc(Cl)cc1)C[C@H]2C CHEMBL4780530 IC50 3.0 nM
CNC(=O)c1cc(C(=O)N[C@H]2[C@@H]3COC[C@@H]32)cc2c1O[C@H](CF)[C@H]2c1ccccc1 CHEMBL4637208 pKd 3.162 nM
COc1cc2c(cc1-c1c(C)noc1C)[nH]c1ccnc(-c3c(C4CC4)n[nH]c3C)c12 CHEMBL3581661 Ki 3.2 nM
Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)OCC(C)(COCCOCCOCCNC(=O)C[C@@H]2N=C(c3ccc(Cl)cc3)c3c(sc(C)c3C)-n3c(C)nnc32)COCCOCCOCCNC(=O)C[C@@H]2N=C(c3ccc(Cl)cc3)c3c(sc(C)c3C)-n3c(C)nnc32)C(C)(C)C)cc1 CHEMBL5279987 DC50 3.3 nM
Cc1cc(-c2ccc3nc(C4CCOCC4)n(CCOC(F)(F)F)c3c2)cn(C)c1=O CHEMBL5274024 Kd 3.5 nM
Cc1cc2c(-c3ccco3)cnc(N[C@@H]3CCN(C)C[C@H]3C(=O)NC3CCCCC3)c2[nH]c1=O CHEMBL4648362 pKd 3.981 nM
Cc1cc(-c2nc3ccccc3n2C[C@@H]2CCCN(C(=O)C3CCN(C(C)C)CC3)C2)cn(C)c1=O CHEMBL5405343 pKd 3.981 nM
Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)Nc1ccc(O)cc1)c1nnc(C)n1-2 CHEMBL3581647 Ki 4.0 nM
Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)OC(C)(C)C)c1nnc(C)n1-2 CHEMBL1957266 IC50 4.0 nM
CCc1n[nH]c(CC)c1-c1nccc2[nH]c3cc(-c4c(C)noc4C)c(OC)cc3c12 CHEMBL3581660 Ki 4.2 nM
Cc1nnc2n1-c1ccc(-c3ccc(CNCCCCC#Cc4cccc5c4CN(C4CCC(=O)NC4=O)C5=O)cc3)cc1C(Nc1ccc(Cl)cc1)CC2 CHEMBL5430924 Ki 4.73 nM
Cc1nnc2n1-c1ccc(-c3ccc(CNCC#Cc4cccc5c4CN(C4CCC(=O)NC4=O)C5=O)cc3)cc1C(Nc1ccc(Cl)cc1)CC2 CHEMBL5417801 Ki 4.81 nM
Cc1nnc2n1-c1ccc(-c3cnn(CC(=O)NCCCC#Cc4cccc5c4CN(C4CCC(=O)NC4=O)C5=O)c3)cc1C(Nc1ccc(Cl)cc1)CC2 CHEMBL5436817 Ki 4.96 nM
COCc1nc2cnc3cc(-c4c(C)noc4C)c(OC[C@H]4CCNC4)cc3c2n1[C@H](C)c1ccccc1 CHEMBL4639128 Kd 5.0 nM
CNC(=O)c1cc(C(=O)N[C@H]2C[C@@H]2C)cc(C(O)c2ccccc2)n1 CHEMBL4862372 pKd 5.012 nM
Cc1nnc2n1-c1ccc(-c3ccc(CNCCCC#Cc4cccc5c4CN(C4CCC(=O)NC4=O)C5=O)cc3)cc1C(Nc1ccc(Cl)cc1)CC2 CHEMBL5422958 Ki 5.04 nM
Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)NCCCCNC(=O)COc1cccc3c1C(=O)N(C1CCC(=O)NC1=O)C3=O)c1nnc(C)n1-2 CHEMBL4094346 Ki 5.26 nM
Cc1noc(C)c1-c1ccc2c(c1)C(c1ccccc1)(N1CCC[C@H](N)C1)C(=O)N2 CHEMBL3895413 IC50 5.3 nM
Cc1cc(F)cc(C)c1Oc1ccc(C(C)(C)O)cc1-c1cn(C)c(=O)c2cc(-c3cnc(C4CCCC4)[nH]3)oc12 CHEMBL5206088 IC50 5.31 nM
Cc1nnc2n1-c1ccc(-c3ccc(CNCCCCCc4cccc5c4CN(C4CCC(=O)NC4=O)C5=O)cc3)cc1C(Nc1ccc(Cl)cc1)CC2 CHEMBL5393972 Ki 5.42 nM
Cc1nnc2n1-c1ccc(-c3ccc(CNCCC#Cc4cccc5c4CN(C4CCC(=O)NC4=O)C5=O)cc3)cc1C(Nc1ccc(Cl)cc1)CC2 CHEMBL5438712 Ki 5.72 nM
Cc1nnc2n1-c1ccc(-c3ccc(CNCCCCCC#Cc4cccc5c4CN(C4CCC(=O)NC4=O)C5=O)cc3)cc1C(Nc1ccc(Cl)cc1)CC2 CHEMBL5414218 Ki 5.89 nM
CN1CCC(NC(=O)c2cccc(CN3c4ccccc4C=C4c5c(cccc53)C(=O)N4C)c2)CC1 CHEMBL5393744 IC50 6.0 nM
Cc1nnc2n1-c1ccc(-c3cnn(CC(=O)NCCCCCC#Cc4cccc5c4CN(C4CCC(=O)NC4=O)C5=O)c3)cc1C(Nc1ccc(Cl)cc1)CC2 CHEMBL5429493 Ki 6.29 nM
CC(=O)N1c2ccc(C(N)=O)cc2[C@H](Nc2ncc(Cl)cn2)C[C@@H]1C CHEMBL5195288 pKd 6.31 nM
Cc1nnc2n1-c1ccc(-c3cnn(CC(=O)NCCCCC#Cc4cccc5c4CN(C4CCC(=O)NC4=O)C5=O)c3)cc1C(Nc1ccc(Cl)cc1)CC2 CHEMBL5411981 Ki 6.62 nM
Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)NCCOCCOCCN)c1nnc(C)n1-2 CHEMBL4577491 IC50 7.0 nM
CC(=O)OC[C@]12CC[C@H]3[C@@H](C[C@H]4O[C@]45CC=CC(=O)[C@]35C)[C@]1(O)CC[C@@]2(O)[C@@](C)(O)[C@H]1CC(C)=C(C)C(=O)O1 CHEMBL3605565 IC50 7.11 nM
COc1cc2c(cc1-c1c(C)noc1C)ncc1[nH]c(=O)n([C@H](C)c3ccccn3)c12 CHEMBL2017291 Ki 7.2 nM
Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCCOCCNC(=O)C[C@@H]2N=C(c3ccc(Cl)cc3)c3c(sc(C)c3C)-n3c(C)nnc32)C(C)(C)C)cc1 CHEMBL4215078 Kd 7.6 nM
CCn1cc(-c2ccc3c(c2)C(Nc2ccc(Cl)cc2)CCc2nnc(C)n2-3)cn1 CHEMBL4438006 Ki 8.2 nM
Cc1nnn2c1-c1ccc(-c3ccc(N)nc3)cc1N(c1ccc(Cl)cc1)CC2 CHEMBL4168815 IC50 9.0 nM
CCc1[nH]nc(-c2ccccc2)c1-c1nccc2[nH]c3cc(-c4c(C)noc4C)c(OC)cc3c12 CHEMBL3581662 Ki 9.4 nM
Cc1noc(C)c1-c1ccc2c(c1)C(c1ccccc1)(N1CCC[C@H](O)C1)C(=O)N2 CHEMBL3903717 IC50 9.9 nM
Cc1nnn2c1-c1ccc(-c3cc[nH]n3)cc1N(c1ccc(Cl)cc1)CC2 CHEMBL4177080 IC50 10.0 nM
Cc1ccc(-c2ccc3c(c2)N(c2ccc(Cl)cc2)CCn2nnc(C)c2-3)cn1 CHEMBL4173305 IC50 10.0 nM
Cn1cc2c3c(c[nH]c3c1=O)CN(c1ccc(F)cc1F)c1ccc(CS(C)(=O)=O)cc1-2 CHEMBL4217457 Ki 10.0 nM
Cn1cc2c3c(c[nH]c3c1=O)CN(c1ccccn1)c1ccc(CS(C)(=O)=O)cc1-2 CHEMBL4208129 Ki 10.0 nM
COCc1nc2cnc3cc(-c4c(C)noc4C)c(OC)cc3c2n1[C@H](C)c1ccccc1 CHEMBL4635329 pIC50 10.0 nM
Cc1nnn2c1-c1ccccc1N(c1ccc(Cl)cc1)C[C@H]2C CHEMBL4170756 IC50 11.0 nM
Cc1noc(C)c1-c1ccc2nc(-c3cnn(CC(C)(C)O)c3)nc(N3CCOC[C@@H]3c3ccccc3)c2c1 CHEMBL4749664 Kd 11.0 nM
Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)Nc1ccc(C(=O)NO)cc1)c1nnc(C)n1-2 CHEMBL4850926 IC50 11.0 nM
Cc1nnc2n1-c1ccc(-c3cnn(C)c3)cc1C(Nc1ccc(Cl)cc1)CC2 CHEMBL4471776 Ki 11.1 nM
Cc1nnn2c1-c1ccc(C(=O)N[C@@H](C)c3ccccc3)cc1N(c1ccc(Cl)cc1)CC2 CHEMBL4162832 IC50 12.0 nM
CCS(=O)(=O)Nc1ccc(Oc2ccc(F)cc2F)c(-c2cn(C)c(=O)c3[nH]ccc23)c1 CHEMBL3987016 Ki 12.2 nM
CNC(=O)c1cc(C(=O)NC2CC2)cn(Cc2ccccc2)c1=O CHEMBL4635134 pKd 12.59 nM
Cc1cc(F)cc(C)c1Oc1ccc(C(C)(C)O)cc1-c1cn(C)c(=O)c2cc(-c3cnc(C4CCCCC4)[nH]3)oc12 CHEMBL5204783 IC50 12.81 nM
CCn1nc(C)c2c1C(=O)N(c1cc(C)c(=O)n(C)c1)C2c1ccc(Cl)cc1F CHEMBL3654293 IC50 13.0 nM
Cc1cc(N2C(=O)c3c(c(C4CC4)nn3C)[C@H]2c2ccc(Cl)cc2)cn2c(C)nnc12 CHEMBL3654322 IC50 13.0 nM
CCc1nn(C2CC2)c2c1[C@@H](c1ccc(Cl)cc1)N(c1cc(C)c3nnc(C)n3c1)C2=O CHEMBL3650952 IC50 13.0 nM
Cc1cc(N2C(=O)c3c(c(CO)nn3C3CC3)[C@H]2c2ccc(Cl)cc2)cn2c(C)nnc12 CHEMBL3654324 IC50 13.0 nM
Cc1nnn2c1-c1ccc(C(=O)N[C@H](C)c3ccccc3)cc1N(c1ccc(Cl)cc1)CC2 CHEMBL4176902 IC50 13.0 nM
Cc1nnn2c1-c1ccccc1N(c1ccc(Cl)cc1)C[C@@H]2C CHEMBL4159455 IC50 13.0 nM
Cc1nnc2n1-c1ccc(-c3cn[nH]c3)cc1C(Nc1ccc(Cl)cc1)CC2 CHEMBL4533303 Ki 13.9 nM
Cc1nn(C2CC2)c2c1C(c1ccc(Cl)cc1)N(c1cc(C)c3nnn(C)c3n1)C2=O CHEMBL3650955 IC50 14.0 nM
Cc1noc(C)c1-c1ccc2c(c1)C(O)(c1ccsc1)C(=O)N2 CHEMBL3895277 IC50 14.0 nM
Cc1nnn2c1-c1ccc(-c3cnc(N)nc3)cc1N(c1ccc(Cl)cc1)CC2 CHEMBL4176672 IC50 14.0 nM
Cc1nnn2c1-c1ccc(C(=O)Nc3ccccc3)cc1N(c1ccc(Cl)cc1)CC2 CHEMBL4169698 IC50 14.0 nM
Cc1nnc2n1-c1sc(C#Cc3cnn(C4CN(c5ccc6c(c5)C(=O)N(C5CCC(=O)NC5=O)C6=O)C4)c3)c(Cc3ccccc3)c1COC2 CHEMBL5406183 Kd 14.0 nM
Cc1nn(C(C)C)c2c1[C@@H](c1ccc(Cl)cc1)N(c1cc(C)c(=O)n(C)c1)C2=O CHEMBL3650949 IC50 15.0 nM
CNC(=O)c1cc(C(=O)NC2CC2)cn(Cc2cccc3[nH]ccc23)c1=O CHEMBL4648431 pIC50 15.85 nM
Cc1nn(C2CC2)c2c1C(c1ccc(Cl)cc1)N(c1cc(C)c3nnc(C(F)F)n3n1)C2=O CHEMBL3654318 IC50 16.0 nM
Cc1nn(C2CC2)c2c1C(c1ccc(Cl)cc1)N(c1cc(C)c3nnn(C)c3c1)C2=O CHEMBL3650933 IC50 16.0 nM
Cc1nnn2c1-c1ccc(C(=O)O)cc1N(c1ccc(Cl)cc1)CC2 CHEMBL4166861 IC50 16.0 nM
Cc1nn(C2CC2)c2c1[C@@H](c1ccc(Cl)cc1)N(c1cc(C)c3nnc(C)n3c1)C2=O CHEMBL3650964 IC50 17.0 nM
Cn1cc2c3c(c[nH]c(=O)c31)-c1cc(CS(C)(=O)=O)ccc1N(c1ccc(F)cc1)C2 CHEMBL4215988 Ki 17.0 nM
COC(=O)c1ccc2c(c1)N(c1ccc(Cl)cc1)CCn1nnc(C)c1-2 CHEMBL4174764 IC50 18.0 nM
CC(=O)OC[C@]12CC[C@H]3[C@@H](CC=C4CC=CC(=O)[C@@]43C)[C@]1(O)CC[C@@]2(O)[C@@](C)(O)[C@H]1CC(C)=C(C)C(=O)O1 CHEMBL3605564 IC50 18.0 nM
Cc1cc2n3c(c[nH]c(=O)c13)CN(C(=O)c1ccc3ccccc3c1)c1ccc(CS(C)(=O)=O)cc1-2 CHEMBL5437856 IC50 18.9 nM
Cc1nnc2n1-c1ccccc1C(c1ccccc1)=NC2NC(=O)OCc1ccccc1 CHEMBL2153434 Kd 19.0 nM
Cc1nnc2n1-c1ccccc1C(c1ccccc1)=N[C@H]2NC(=O)OCc1ccccc1 CHEMBL1738926 Kd 19.0 nM
Cc1nn(C2CC2)c2c1[C@@H](c1ccc(Cl)cc1)N(c1cc(C)c(=O)n(C)c1)C2=O CHEMBL3650899 IC50 19.0 nM
Cc1nnn2c1-c1ccccc1N(c1ccccc1)CC2 CHEMBL4164698 IC50 19.0 nM
Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=NC(CC(=O)OC(C)(C)C)c1nnc(C)n1-2 CHEMBL2132936 IC50 19.1 nM
CC(=O)N1c2ccc(C3=CCNCC3)cc2N(Cc2ccccc2CO)C[C@@H]1C1CC1 CHEMBL4218735 pKd 19.5 nM
COCc1nn(C2CC2)c2c1[C@@H](c1ccc(Cl)cc1)N(c1cc(N)c3nnc(C)n3c1)C2=O CHEMBL3654321 IC50 20.0 nM
CN(C)CCN1CCN(c2nc(NCc3cccc(Cl)c3)c3cc(-c4ccc(=O)n(C)c4)ccc3n2)CC1 CHEMBL4288569 Kd 20.0 nM
Cc1cc(C)cc(Oc2cccc(-c3c(C)nnn3C3CCN(CCN(C)C)CC3)n2)c1 CHEMBL5083660 Kd 20.0 nM
CC(=O)N1CCc2c(sc3nc(SCC(=O)Nc4cccnc4C)n(Cc4ccco4)c(=O)c23)C1 CHEMBL5082786 IC50 20.0 nM
Cc1nn(C2CC2)c2c1[C@@H](c1ccc(Cl)cc1)N(c1cc(Cl)c(=O)n(C)c1)C2=O CHEMBL3650901 IC50 21.0 nM
Cc1nnn2c1-c1ccccc1N(Cc1cccc(Br)c1)CC2 CHEMBL4174918 IC50 21.0 nM
Cc1nnn2c1-c1ccc(C(=O)NCc3ccccc3)cc1N(c1ccc(Cl)cc1)CC2 CHEMBL4166286 IC50 21.0 nM
Cc1nnn2c1-c1ccc(C(=O)NS(=O)(=O)c3ccccc3)cc1N(c1ccc(Cl)cc1)CC2 CHEMBL4174587 IC50 21.0 nM
CCNC(=O)C[C@@H]1N=C(c2ccc(Cl)cc2)c2cc(OC)ccc2-n2c(C)nnc21 CHEMBL1232461 Kd 22.0 nM
Cc1n[nH]c2c1[C@@H](c1ccc(Cl)cc1)N(c1cc(C)c3nnc(C)n3c1)C2=O CHEMBL3654323 IC50 23.0 nM
Cc1noc(C)c1-c1ccc2c(c1)C(N[C@H](C)CO)(c1ccccc1)C(=O)N2 CHEMBL3910920 IC50 23.0 nM
Cc1noc(C)c1-c1ccc2c(c1)C(NC[C@@H](C)O)(C1CCCCC1)C(=O)N2 CHEMBL3910409 IC50 23.0 nM
Cc1nnn2c1-c1ccc(C(=O)N[C@@H](C)c3ccc(F)cc3)cc1N(c1ccc(Cl)cc1)CC2 CHEMBL4173537 IC50 23.0 nM
COc1ncccc1-n1nc(C)c2c1C(=O)N(c1cc(C)c3nnc(C)n3n1)C2c1ccc(Cl)cc1 CHEMBL3650956 IC50 24.0 nM
CNc1cc(N2C(=O)c3c(c(C)nn3C3CC3)[C@H]2c2ccc(Cl)cc2)nn2c(C)nnc12 CHEMBL3654320 IC50 24.0 nM
Cc1nn(C2CC2)c2c1[C@@H](c1ccc(Cl)cc1F)N(c1cc(C)c3nnc(C)n3c1)C2=O CHEMBL3654313 IC50 25.0 nM
Cc1noc(C)c1-c1ccc2c(c1)C(O)(C1CCCCC1=O)C(=O)N2 CHEMBL3929288 IC50 25.0 nM
Cc1nnn2c1-c1ccccc1N(c1ccc(Cl)cc1)CC2 CHEMBL4169877 IC50 25.0 nM
Cc1ncsc1-c1ccc2c(c1)OCCOCCOC[C@@H](NC(=O)C[C@H]1N=C(c3ccc(Cl)cc3)c3c(sc(C)c3C)-n3c(C)nnc31)COCCOCCOCC(=O)N[C@@H](C(C)(C)C)C(=O)N1C[C@H](O)C[C@H]1C(=O)NC2 CHEMBL5283149 DC50 25.0 nM
Cc1cc(-c2cc3c4c(c2)n(Cc2ccccc2)c(=O)n4CCO3)cn(C)c1=O CHEMBL5395771 IC50 25.0 nM
Cc1nnc2n1-c1sc(C#Cc3cnn(C4CN(c5cccc6c5C(=O)N(C5CCC(=O)NC5=O)C6=O)C4)c3)c(Cc3ccccc3)c1COC2 CHEMBL5409305 Kd 26.0 nM
COc1ncc(-n2nc(C)c3c2C(=O)N(c2cc(C)c(=O)n(C)c2)[C@@H]3c2ccc(Cl)cc2)c(OC)n1 CHEMBL3650945 IC50 27.0 nM
COc1ncccc1-n1nc(C)c2c1C(=O)N(c1cc(C)c3nnn(C)c3n1)C2c1ccc(Cl)cc1 CHEMBL3650954 IC50 27.0 nM
Cc1nn(C2CC2)c2c1C(c1ccc(Cl)cc1)N(c1cc(C)c3nnc(C)n3c1)C2=O CHEMBL3650938 IC50 27.0 nM
Cc1nn(C2CCC2)c2c1C(c1ccc(Cl)cc1)N(c1cc(C)c(=O)n(C)c1)C2=O CHEMBL3650940 IC50 28.0 nM
Cc1nn(-c2ccnn2C)c2c1C(c1ccc(Cl)cc1)N(c1cc(C)c3nnc(C)n3c1)C2=O CHEMBL3650937 IC50 28.0 nM
CCc1nn(C2CC2)c2c1C(c1ccc(Cl)cc1)N(c1cc(C)c(=O)n(C)c1)C2=O CHEMBL3650918 IC50 28.0 nM
COc1ncc(-n2nc3c(c2C(C)C)C(c2ccc(Cl)cc2)N(c2cc(C)c4nnc(C)n4c2)C3=O)c(OC)n1 CHEMBL3650916 IC50 28.0 nM
CCc1nn(C2CC2)c2c1C(c1ccc(Cl)cc1)N(c1cc(C)c3nnc(C)n3c1)C2=O CHEMBL3650919 IC50 29.0 nM
Cc1nn(C(C)C)c2c1C(c1ccc(Cl)cc1F)N(c1cc(C)c3nnc(C)n3c1)C2=O CHEMBL3654291 IC50 30.0 nM
COc1ccccc1-n1nc(C)c2c1C(=O)N(c1cc(C)c3nnc(C)n3c1)C2c1ccc(F)cc1F CHEMBL3654300 IC50 30.0 nM
Cc1cc(N2C(=O)c3nn(C4CC4)c(C)c3C2c2ccc(Cl)cc2)cn2c(C)nnc12 CHEMBL3650939 IC50 31.0 nM
CCn1nc(C)c2c1C(=O)N(c1cc(C)c3nnc(C)n3c1)[C@@H]2c1ccc(F)cc1F CHEMBL3654314 IC50 31.0 nM
CC(=O)N1c2ccc(-c3cnc(C(N)=O)nc3)cc2N(Cc2ccccc2CO)C[C@@H]1C1CC1 CHEMBL4213809 pIC50 31.62 nM
CCNC(=O)c1cc(Cc2cccc3[nH]ccc23)nc(-c2cn(C)nn2)c1 CHEMBL4856853 pIC50 31.62 nM
CNC(=O)c1cc(C(=O)N[C@H]2CC[C@H](O)CC2)c([C@@H](C)c2ccccc2)o1 CHEMBL4865767 pIC50 31.62 nM
Cc1nn(-c2ccnn2C)c2c1[C@@H](c1ccc(Cl)cc1)N(c1cc(C)c3nnc(C)n3c1)C2=O CHEMBL3650970 IC50 32.0 nM
CCn1nc(C)c2c1C(=O)N(c1cc(C)c3nnc(C)n3c1)C2c1ccc(Cl)cc1 CHEMBL3650961 IC50 32.0 nM
CC(=O)Nc1c(F)cc(C(=O)N[C@H]2CC[C@H](O)CC2)cc1O[C@@H](C)c1ccccc1 CHEMBL4636881 Kd 32.0 nM
COc1cc2c(cc1-c1c(C)noc1C)ncc1[nH]c(=O)n(C(C)c3ccccc3)c12 CHEMBL2017287 Kd 32.0 nM
CCC(C)n1ccc2c(C(=O)NCc3c(C)cc(C)[nH]c3=O)cc(-c3cn(C)c(=O)c4[nH]ccc34)cc21 CHEMBL5434556 IC50 32.0 nM
Cc1nn(C(C)C)c2c1[C@@H](c1ccc(Cl)cc1F)N(c1cc(C)c3nnc(C)n3c1)C2=O CHEMBL3654312 IC50 33.0 nM
Cc1cc(N2C(=O)c3c(c(C4CC4)nn3C)C2c2ccc(Cl)cc2)cn2c(C)nnc12 CHEMBL3650974 IC50 33.0 nM
Cc1noc(C)c1-c1ccc2c(c1)C(N)(c1ccccc1)C(=O)N2 CHEMBL3955162 IC50 35.0 nM
Cc1[nH]c(-c2cc(NS(C)(=O)=O)ccc2Oc2ccccc2)c2c1C(=O)CCC2 CHEMBL4063051 Ki 35.0 nM
CC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(-c2scnc2C)cc1)C(C)(C)SCCCCCNC(=O)C[C@@H]1N=C(c2ccc(Cl)cc2)c2c(sc(C)c2C)-n2c(C)nnc21 CHEMBL5281933 Kd 35.0 nM
CCn1nc(C)c2c1C(=O)N(c1cc(C)c3nnc(C)n3c1)C2c1ccc(Cl)cc1F CHEMBL3654308 IC50 36.0 nM
COc1ncccc1-n1nc(C)c2c1C(=O)N(c1cc(C)c3nnc(C)n3c1)C2c1ccc(Cl)cc1 CHEMBL3650946 IC50 36.0 nM
CCc1c2c(nn1CCO)C(=O)N(c1cc(C)c3onc(C)c3c1)C2c1ccc(Cl)cc1 CHEMBL3650928 IC50 36.0 nM
COc1ncccc1-n1nc(C)c2c1C(=O)N(c1cc(C)c3nnc(C)n3c1)C2c1ccc(Cl)cc1F CHEMBL3654307 IC50 36.0 nM
Cc1nnn2c1-c1ccc(CO)cc1N(c1ccc(Cl)cc1)CC2 CHEMBL4166455 IC50 36.0 nM
Cc1cc(N2C(=O)c3nn(C(C)C)c(C)c3C2c2ccc(F)cc2F)cn2c(C)nnc12 CHEMBL3654298 IC50 37.0 nM
COc1ncccc1-n1nc(C)c2c1C(=O)N(c1cc(C)c(=O)n(C)c1)[C@@H]2c1ccc(Cl)cc1 CHEMBL3650973 IC50 37.0 nM
Cc1nn(-c2ccnn2C)c2c1C(c1ccc(Cl)cc1)N(c1cc(C)c3nnc(C)n3n1)C2=O CHEMBL3650959 IC50 37.0 nM
Cc1[nH]c(C(=O)Nc2cc(S(=O)(=O)N3CCOCC3)ccc2OCCCCCCCC(=O)NO)c2c1C(=O)CCCC2 CHEMBL5083849 Kd 37.0 nM
Cc1cc(N2C(=O)c3c(c(C4CC4)nn3-c3ccnn3C)C2c2ccc(Cl)cc2)cn2c(C)nnc12 CHEMBL3650962 IC50 38.0 nM
Cc1nn(C(=O)N(C)C)c2c1C(c1ccc(Cl)cc1)N(c1cc(C)c3nnc(C)n3c1)C2=O CHEMBL3654326 IC50 39.0 nM
Cc1nnn2c1-c1ccc(C(=O)NC(c3ccccc3)c3ccccc3)cc1N(c1ccc(Cl)cc1)CC2 CHEMBL4166671 IC50 39.0 nM
CCn1nc(C)c2c1C(=O)N(c1cc(C)c3nnc(C)n3c1)C2c1ccc(F)cc1F CHEMBL3654304 IC50 40.0 nM
CCc1c2c(nn1C1CC1)C(=O)N(c1cc(C)c(=O)n(C)c1)C2c1ccc(Cl)cc1 CHEMBL3650917 IC50 40.0 nM
Cc1nn(C2CC2)c2c1[C@@H](c1ccc(F)cc1F)N(c1cc(C)c3nnc(C)n3c1)C2=O CHEMBL3654311 IC50 40.0 nM
COCc1nn(C2CC2)c2c1[C@@H](c1ccc(Cl)cc1)N(c1cc(C)c(=O)n(C)c1)C2=O CHEMBL3654290 IC50 42.0 nM
COc1ccccc1-n1nc(C)c2c1C(=O)N(c1cc(C)c3nnc(C)n3c1)C2c1ccc(Cl)cc1F CHEMBL3654310 IC50 42.0 nM
Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)NCCOCCOCCNC(=O)OC(C)(C)C)c1nnc(C)n1-2 CHEMBL4436481 IC50 42.0 nM
CNC(=O)c1ncc2c(n1)[nH]c1cc(-c3c(C)noc3C)c(OC)cc12 CHEMBL4228904 Ki 42.4 nM
Cc1cc(N2C(=O)c3nn(C4CC4)c(C)c3[C@H]2c2ccc(Cl)cc2)cn(C)c1=O CHEMBL3650874 IC50 43.0 nM
CCc1nn(CCOC)c2c1C(c1ccc(Cl)cc1)N(c1cc(C)c(=O)n(C)c1)C2=O CHEMBL3650934 IC50 44.0 nM
CCn1nc(C)c2c1C(=O)N(c1cc(C)c3nnc(C)n3c1)[C@@H]2c1ccc(Cl)cc1F CHEMBL3654315 IC50 44.0 nM
Cc1nnn2c1-c1ccccc1N(c1ccc(Cl)cc1)CC2CCO CHEMBL4162818 IC50 44.0 nM
Cc1nn(C[C@H](O)C(F)(F)F)c2c1[C@@H](c1ccc(Cl)cc1)N(c1cc(C)c3nnc(C)n3c1)C2=O CHEMBL3654325 IC50 45.0 nM
CCn1nc2c(c1C)C(c1ccc(Cl)cc1)N(c1cc(C)c3nnc(C)n3c1)C2=O CHEMBL3650960 IC50 46.0 nM
CNCc1ccc(-c2ccc3c(c2)C(Nc2ccc(Cl)cc2)CCc2nnc(C)n2-3)cc1 CHEMBL5436394 Ki 47.24 nM
Cc1cc(N2C(=O)c3c(c(CF)nn3C3CC3)C2c2ccc(Cl)cc2)cn2c(C)nnc12 CHEMBL3654288 IC50 50.0 nM
Cc1cc2n3c(c[nH]c(=O)c13)CN(C(=O)c1cccc3ccccc13)c1ccc(CS(C)(=O)=O)cc1-2 CHEMBL5440806 IC50 50.3 nM
CCn1nc2c(c1C)C(c1ccc(F)cc1F)N(c1cc(C)c3nnc(C)n3c1)C2=O CHEMBL3654305 IC50 51.0 nM
Cc1cc(N2C(=O)c3c(c(CO)nn3C3CC3)C2c2ccc(Cl)cc2)cn2c(C)nnc12 CHEMBL3650976 IC50 52.0 nM
Cc1nn(C2CC2)c2c1C(c1ccc(Cl)cc1)N(c1cn(C)c(=O)c3[nH]ccc13)C2=O CHEMBL3654289 IC50 52.0 nM
Cc1nnn2c1-c1ccc(Cn3cccn3)cc1N(c1ccc(Cl)cc1)CC2 CHEMBL4161952 IC50 52.0 nM
CN1C(=O)c2c(F)cccc2Oc2cc(N[C@H]3CC[C@H](O)CC3)ncc21 CHEMBL4763016 Kd 52.0 nM
COCc1nn(C2CC2)c2c1C(c1ccc(Cl)cc1)N(c1cc(C)c3nnc(C)n3c1)C2=O CHEMBL3650975 IC50 53.0 nM
Cc1nn(C2CC2)c2c1C(c1ccc(Cl)cc1)N(c1ccc3nnn(C)c3n1)C2=O CHEMBL3650947 IC50 55.0 nM
CCc1nn(CCO)c2c1C(c1ccc(Cl)cc1)N(c1cc(C)c(=O)n(C)c1)C2=O CHEMBL3650926 IC50 57.0 nM
CCc1nn(-c2ccnn2C)c2c1C(c1ccc(Cl)cc1)N(c1cc(C)c(=O)n(C)c1)C2=O CHEMBL3650936 IC50 57.0 nM
COc1ncccc1-n1nc(C)c2c1C(=O)N(c1cc(C)c(=O)n(C)c1)C2c1ccc(Cl)cc1 CHEMBL3650920 IC50 58.0 nM
Cc1cc(N2C(=O)c3c(cnn3C(C)C)C2c2ccc(Cl)cc2)cn(C)c1=O CHEMBL3650888 IC50 59.0 nM
CCc1nn(CCOC)c2c1C(c1ccc(Cl)cc1)N(c1cc(C)c3nnc(C)n3c1)C2=O CHEMBL3650935 IC50 59.0 nM
Cc1cc(N2C(=O)c3nn(C(C)C)c(C)c3C2c2ccc(Cl)cc2F)cn2c(C)nnc12 CHEMBL3654292 IC50 60.0 nM
CCn1nc2c(c1C)C(c1ccc(Cl)cc1F)N(c1cc(C)c3nnc(C)n3c1)C2=O CHEMBL3654309 IC50 61.0 nM
COc1ncc(-n2nc3c(c2C)C(c2ccc(Cl)cc2)N(c2cc(Cl)c(=O)n(C)c2)C3=O)c(OC)n1 CHEMBL3650905 IC50 61.0 nM
CCc1nn(C2CC2)c2c1C(c1ccc(Cl)cc1)N(c1cc(OC)c3nnc(C)n3c1)C2=O CHEMBL3650932 IC50 61.5 nM
Cc1nn(C2CC2)c2c1C(c1ccc(Cl)cc1F)N(c1cc(C)c3nnc(C)n3c1)C2=O CHEMBL3654301 IC50 62.0 nM
COc1nnc2ccc(N3CCC(c4ccc(OCCN5CCN(C)C(=O)[C@H]5C)cc4)CC3)nn12 CHEMBL4078100 pKi 63.1 nM
COc1ncccc1-n1nc2c(c1C)C(c1ccc(Cl)cc1F)N(c1cc(C)c3nnc(C)n3c1)C2=O CHEMBL3654317 IC50 65.0 nM
Cc1c2c(nn1C1CC1)C(=O)N(c1cc(Cl)c(=O)n(C)c1)[C@@H]2c1ccc(Cl)cc1 CHEMBL3650872 IC50 65.0 nM
Cc1cc(N2C(=O)c3nn(C)cc3[C@H]2c2ccc(Cl)cc2)cn(C)c1=O CHEMBL3650869 IC50 66.0 nM
Cc1c2c(nn1C)C(=O)N(c1cc(Cl)c(=O)n(C)c1)[C@@H]2c1ccc(Cl)cc1 CHEMBL3650860 IC50 67.0 nM
COc1ncc(-n2nc(C)c3c2C(=O)N(c2cc(C)c(=O)n(C)c2)C3c2ccc(Cl)cc2)c(OC)n1 CHEMBL3650902 IC50 69.0 nM
CC(=O)N1c2ccc(-c3ccc(NC(=O)CCCCCCC(=O)NO)cc3)cc2[C@H](NC(=O)OC(C)C)C[C@@H]1C CHEMBL3220922 Kd(app) 70.0 nM
Cc1nn(C(C)C)c2c1C(c1ccc(Cl)cc1F)N(c1cc(C)c(=O)n(C)c1)C2=O CHEMBL3654303 IC50 71.0 nM
COc1ncc(-n2nc3c(c2C(C)C)[C@@H](c2ccc(Cl)cc2)N(c2cc(C)c4onc(C)c4c2)C3=O)c(OC)n1 CHEMBL3650911 IC50 72.0 nM
Cc1nn(C(C)C)c2c1C(c1ccc(F)cc1F)N(c1cc(C)c3nnc(C)n3c1)C2=O CHEMBL3654297 IC50 72.0 nM
COc1ccccc1NC(=O)CSc1nc2sc3c(c2c(=O)n1Cc1ccco1)CCN(C(C)=O)C3 CHEMBL5081350 IC50 72.0 nM
COc1ncccc1-n1nc(C)c2c1C(=O)N(c1cc(Cl)c(=O)n(C)c1)C2c1ccc(Cl)cc1 CHEMBL3650921 IC50 73.0 nM
Cc1nn(C2CC2)c2c1C(c1ccc(OC(F)(F)F)cc1)N(c1cc(C)c(=O)n(C)c1)C2=O CHEMBL3650941 IC50 73.0 nM
Cc1[nH][n+](C2CC2)c2c1C(c1ccc(Cl)cc1)N(c1cc(C)c(=O)n(C)c1)C2=O CHEMBL4110697 IC50 74.0 nM
Cc1n[nH]c2c1C(c1ccc(Cl)cc1F)N(c1cc(C)c3nnc(C)n3c1)C2=O CHEMBL3654306 IC50 75.0 nM
CCOC(=O)N1CC(n2nc(C)c3c2C(=O)N(c2cc(C)c(=O)n(C)c2)C3c2ccc(Cl)cc2)C1 CHEMBL3654284 IC50 76.0 nM
CC(C)n1ncc2c1C(=O)N(c1cc(Cl)c(=O)n(C)c1)C2c1ccc(Cl)cc1 CHEMBL3650890 IC50 76.0 nM
CCOC(=O)N1CC(n2nc(C)c3c2C(=O)N(c2cc(C)c4nnc(C)n4c2)C3c2ccc(Cl)cc2)C1 CHEMBL3654285 IC50 77.0 nM
Cc1cc(N2C(=O)c3nn(C4CC4)c(C)c3C2c2ccc(Cl)cc2)cn(C)c1=O CHEMBL3650873 IC50 77.0 nM
Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)NCCOCCOCCNC(=O)CS(=O)(=O)O)c1nnc(C)n1-2 CHEMBL4576135 IC50 78.0 nM
C[C@H](Oc1ccc(C(=O)NC2CC2)cc1-c1cn(C)nn1)c1ccccn1 CHEMBL4867703 pIC50 79.43 nM
CNC(=O)c1cc(C(=O)N[C@H]2CC[C@H](O)CC2)n([C@@H](C)c2ccccc2)n1 CHEMBL4854042 pIC50 79.43 nM
Cc1cc(N2C(=O)c3c(c(CO)nn3C3CC3)C2c2ccc(Cl)cc2)cn(C)c1=O CHEMBL3654264 IC50 80.0 nM
COc1ncccc1-n1nc2c(c1C)C(c1ccc(F)cc1F)N(c1cc(C)c3nnc(C)n3c1)C2=O CHEMBL3654316 IC50 80.0 nM
Cc1nn(-c2ccnn2C)c2c1[C@@H](c1ccc(Cl)cc1)N(c1cc(C)c(=O)n(C)c1)C2=O CHEMBL3650965 IC50 83.0 nM
Cc1cc(N2C(=O)c3nn(C(C)C)cc3C2c2ccc(Cl)cc2)cn(C)c1=O CHEMBL3650892 IC50 85.0 nM
CC(=O)N1CCc2c(sc3nc(SCC(=O)Nc4cc(Cl)ccc4C)n(Cc4ccco4)c(=O)c23)C1 CHEMBL5080392 IC50 85.0 nM
CCc1nn(CCO)c2c1C(c1ccc(Cl)cc1)N(c1cc(C)c3onc(C)c3c1)C2=O CHEMBL3650927 IC50 86.0 nM
COc1ncccc1-n1nc(C)c2c1C(=O)N(c1cc(C)c3nnc(C)n3c1)C2c1ccc(F)cc1F CHEMBL3654296 IC50 87.0 nM
Cc1nn(C(C)C)c2c1C(c1ccc(Cl)cc1)N(c1cc(C)c(=O)n(C)c1)C2=O CHEMBL3650912 IC50 88.0 nM
CC(C)n1cc2c(n1)C(=O)N(c1cc(Cl)c(=O)n(C)c1)C2c1ccc(Cl)cc1 CHEMBL3650893 IC50 89.0 nM
COCc1nn(C2CC2)c2c1C(c1ccc(Cl)cc1)N(c1cc(C)c(=O)n(C)c1)C2=O CHEMBL3654263 IC50 89.0 nM
CC(=O)OC[C@]12CC[C@H]3[C@@H](C[C@@H]4O[C@@]45CC=CC(=O)[C@]35C)[C@]1(O)CC[C@@]2(O)[C@@](C)(O)[C@H]1CC(C)=C(C)C(=O)O1 CHEMBL3605566 IC50 89.7 nM
Cc1nn(C2CC2)c2c1C(c1ccc(Cl)cc1F)N(c1cc(C)c(=O)n(C)c1)C2=O CHEMBL3654302 IC50 90.0 nM
Cc1nn(C2CC2)c2c1C(c1ccc(F)cc1F)N(c1cc(C)c3nnc(C)n3c1)C2=O CHEMBL3654299 IC50 90.0 nM
Cn1cc(N2C(=O)c3nn(C4CC4)cc3C2c2ccc(Cl)cc2)cc(Cl)c1=O CHEMBL3650889 IC50 91.0 nM
Cc1nn(-c2ccnn2C)c2c1C(c1ccc(Cl)cc1)N(c1cc(C)c(=O)n(C)c1)C2=O CHEMBL3650923 IC50 91.0 nM
CCn1nc2c(c1C)C(c1ccc(Cl)cc1F)N(c1cc(C)c(=O)n(C)c1)C2=O CHEMBL3654294 IC50 93.0 nM
Cc1cc(N2C(=O)c3nn(C4CN(C)C4)c(C)c3C2c2ccc(Cl)cc2)cn2c(C)nnc12 CHEMBL3654287 IC50 93.0 nM
Cc1nnc2n1-c1sc(C#Cc3cnn(CCNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)c3)c(Cc3ccccc3)c1COC2 CHEMBL5421103 Kd 93.0 nM
Cc1ncccc1-n1nc(C)c2c1C(=O)N(c1cc(C)c(=O)n(C)c1)C2c1ccc(Cl)cc1 CHEMBL3650930 IC50 96.0 nM
Cc1ncccc1-n1nc2c(c1C)C(c1ccc(Cl)cc1)N(c1cc(C)c(=O)n(C)c1)C2=O CHEMBL3650929 IC50 97.0 nM
Cc1nn(-c2cncn2C)c2c1C(c1ccc(Cl)cc1)N(c1cc(C)c(=O)n(C)c1)C2=O CHEMBL3650931 IC50 97.0 nM
Cc1c2c(nn1C1CC1)C(=O)N(c1cc(Cl)c(=O)n(C)c1)C2c1ccc(Cl)cc1 CHEMBL3650870 IC50 97.0 nM
Cc1cc(/N=N/c2ccc(S(=O)(=O)Nc3ccccn3)cc2)c(N)cc1O CHEMBL3086883 Ki 100.0 nM
COc1ncc(-n2nc3c(c2C(C)C)C(c2ccc(Cl)cc2)N(c2cc(C)c4onc(C)c4c2)C3=O)c(OC)n1 CHEMBL3639497 IC50 100.0 nM
Cc1cc(N2C(=O)c3c(c(C(F)(F)F)nn3C3CC3)C2c2ccc(Cl)cc2)cn(C)c1=O CHEMBL3650896 IC50 100.0 nM
Cn1cc2c(n1)C(=O)N(c1cc(Cl)c(=O)n(C)c1)[C@@H]2c1ccc(Cl)cc1 CHEMBL3650864 IC50 100.0 nM
CCOc1c2c(nn1C)C(=O)N(c1cc(C)c(=O)n(C)c1)C2c1ccc(Cl)cc1 CHEMBL3650924 IC50 100.0 nM
Cc1nn(C2COC2)c2c1C(c1ccc(Cl)cc1)N(c1cc(C)c3nnc(C)n3c1)C2=O CHEMBL3654268 IC50 100.0 nM
CNC(=O)CN(CC(c1ccccc1)c1ccccc1)C(=O)c1cc(C)c(OC)c(C)c1 CHEMBL4878540 pIC50 100.0 nM
CC(=O)N1CCc2c(sc3nc(SCC(=O)Nc4ccccc4Cl)n(Cc4ccco4)c(=O)c23)C1 CHEMBL5077541 IC50 100.0 nM
Cc1nn(C(C)C)c2c1C(c1ccc(Cl)cc1)N(c1cc(Cl)c(=O)n(C)c1)C2=O CHEMBL3650915 IC50 110.0 nM
Cc1cc(N2C(=O)c3c(cnn3C3CC3)C2c2ccc(Cl)cc2)cn(C)c1=O CHEMBL3650886 IC50 110.0 nM
Cc1n[nH]c2c1C(c1ccc(F)cc1F)N(c1cc(C)c3nnc(C)n3c1)C2=O CHEMBL3654295 IC50 110.0 nM
Cc1cc(N2C(=O)c3nn(C(C)C)c(C)c3C2c2ccc(Cl)cc2)cn(C)c1=O CHEMBL3650913 IC50 110.0 nM
Cc1cc(N2C(=O)c3nn(C4CC4)c(C(F)(F)F)c3C2c2ccc(Cl)cc2)cn(C)c1=O CHEMBL3650894 IC50 110.0 nM
Cc1cc(N2C(=O)c3nn(C4CNC4)c(C)c3C2c2ccc(Cl)cc2)cn2c(C)nnc12 CHEMBL3654281 IC50 110.0 nM
Cc1[nH]c(-c2cc(S(C)(=O)=O)ccc2Oc2ccc(F)cc2F)c2c1C(=O)NCC2 CHEMBL3786012 Ki 110.0 nM
COc1cc2c(cc1-c1c(C)noc1C)[nH]c1ncnc(NCCCCCCC(=O)NO)c12 CHEMBL5405779 IC50 113.0 nM
Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCOCCOCCNC(=O)C[C@@H]2N=C(c3ccc(Cl)cc3)c3c(sc(C)c3C)-n3c(C)nnc32)C(C)(C)C)cc1 CHEMBL4226570 Kd 115.0 nM
CC(=O)N1CC(n2nc(C)c3c2C(=O)N(c2cc(C)c4nnc(C)n4c2)C3c2ccc(Cl)cc2)C1 CHEMBL3654283 IC50 120.0 nM
CNc1cc(N2C(=O)c3c(c(C)nn3C3CC3)C2c2ccc(Cl)cc2)nn2c(C)nnc12 CHEMBL3650958 IC50 120.0 nM
Cc1cc(N2C(=O)c3nn(C4CN(C)C4)c(C)c3C2c2ccc(Cl)cc2)cn(C)c1=O CHEMBL3654270 IC50 120.0 nM
CCc1nn(-c2cnc(OC)nc2OC)c2c1C(c1ccc(Cl)cc1)N(c1cc(C)c(=O)n(C)c1)C2=O CHEMBL3650909 IC50 120.0 nM
CCc1nn(C(=O)N(C)C)c2c1C(c1ccc(Cl)cc1)N(c1cc(C)c(=O)n(C)c1)C2=O CHEMBL3654278 IC50 120.0 nM
Cc1cc(N2C(=O)c3nn(C(=O)N(C)C)c(C)c3[C@H]2c2ccc(Cl)cc2)cn2c(C)nnc12 CHEMBL3654327 IC50 120.0 nM
COc1ncc(-n2nc(C)c3c2C(=O)N(c2cc(Cl)c(=O)n(C)c2)C3c2ccc(Cl)cc2)c(OC)n1 CHEMBL3650903 IC50 120.0 nM
Cc1nn(C2CC2)c2c1C(c1ccc(C(F)(F)F)cc1)N(c1cc(C)c(=O)n(C)c1)C2=O CHEMBL3650943 IC50 120.0 nM
COc1c2c(nn1C)C(=O)N(c1cc(C)c(=O)n(C)c1)C2c1ccc(Cl)cc1 CHEMBL3650925 IC50 120.0 nM
CC[C@@H]1C(=O)N(C)c2cnc(N(C)c3ccc(-c4nc5c(C(N)=O)cccc5[nH]4)cc3OC)nc2N1C1CCCC1 CHEMBL5084388 IC50 123.0 nM
Cc1cc(N2C(=O)c3nn(C4COC4)c(C)c3C2c2ccc(Cl)cc2)cn(C)c1=O CHEMBL3654265 IC50 130.0 nM
Cc1nn(C)c2c1C(c1ccc(Cl)cc1)N(c1cc(C)c(=O)n(C)c1)C2=O CHEMBL3650906 IC50 130.0 nM
Cc1cc(N2C(=O)c3nn(C(=O)N(C)C)c(C)c3C2c2ccc(Cl)cc2)cn(C)c1=O CHEMBL3654272 IC50 130.0 nM
Cn1cc2c(n1)C(=O)N(c1cc(Cl)c(=O)n(C)c1)C2c1ccc(Cl)cc1 CHEMBL3650863 IC50 130.0 nM
Cc1cc(N2C(=O)c3nn(C4COC4)c(C)c3C2c2ccc(Cl)cc2)cn2c(C)nnc12 CHEMBL3654267 IC50 130.0 nM
Cc1c2c(nn1C(C)C)C(=O)N(c1cc(Cl)c(=O)n(C)c1)C2c1ccc(Cl)cc1 CHEMBL3650914 IC50 130.0 nM
CC(=O)N1CC(n2nc(C)c3c2C(=O)N(c2cc(C)c(=O)n(C)c2)C3c2ccc(Cl)cc2)C1 CHEMBL3654282 IC50 130.0 nM
Cc1nn(C2COC2)c2c1C(c1ccc(Cl)cc1)N(c1cc(C)c(=O)n(C)c1)C2=O CHEMBL3654266 IC50 130.0 nM
CC(=O)OC[C@]12CC[C@H]3[C@@H](CC=C4C=CCC(=O)[C@@]43C)[C@]1(O)CC[C@@]2(O)[C@@](C)(O)[C@H]1CC(C)=C(C)C(=O)O1 CHEMBL3605560 IC50 130.7 nM
COc1cc(/C=C/C(=O)Nc2ccc3c(c2)C2(C(=O)N3)C(C(=O)OC(C)(C)C)CC3CSCN32)cc(OC)c1OC CHEMBL5218870 Ki 131.0 nM
Cc1[nH]nc2c1C(c1ccc(Cl)cc1)N(c1cc(C)c(=O)n(C)c1)C2=O CHEMBL3650879 IC50 140.0 nM
CNC(=O)n1nc2c(c1C)C(c1ccc(Cl)cc1)N(c1cc(C)c(=O)n(C)c1)C2=O CHEMBL3654275 IC50 140.0 nM
Cc1noc(C)c1-c1ccc2c(c1)C(O)(C1CCOCC1)C(=O)N2 CHEMBL3963603 IC50 140.0 nM
CC(=O)N1CCc2c(sc3nc(SCC(=O)Nc4ccccc4)n(Cc4ccco4)c(=O)c23)C1 CHEMBL5069987 IC50 140.0 nM
Cn1cc(N2C(=O)c3nn(C4CC4)c(C(F)(F)F)c3C2c2ccc(Cl)cc2)cc(Cl)c1=O CHEMBL3650891 IC50 150.0 nM
Cc1nn(C2CC2)c2c1C(c1ccc(Cl)cc1)N(c1cc(Cl)c(=O)n(C)c1)C2=O CHEMBL3650877 IC50 150.0 nM
Cc1cc(N2C(=O)c3nn(C)cc3C2c2ccc(Cl)cc2)cn(C)c1=O CHEMBL3650866 IC50 150.0 nM
CCc1nn(C)c2c1C(c1ccc(Cl)cc1)N(c1cc(OC)c3nnc(C)n3c1)C2=O CHEMBL3650950 IC50 150.0 nM
Cc1nn(C(=O)N(C)C)c2c1C(c1ccc(Cl)cc1)N(c1cc(C)c(=O)n(C)c1)C2=O CHEMBL3654273 IC50 150.0 nM
CCOc1ccccc1NC(=O)CSc1nc2sc3c(c2c(=O)n1Cc1ccco1)CCN(C(C)=O)C3 CHEMBL5083228 IC50 150.0 nM
CC(=O)N1c2ccc(-c3ccc(C(=O)O)cc3)cc2[C@H](Nc2ccc(C)cc2)C[C@@H]1C CHEMBL3353999 pIC50 158.49 nM
Cn1cc(N2C(=O)c3c(cnn3C3CC3)C2c2ccc(Cl)cc2)cc(Cl)c1=O CHEMBL3650887 IC50 160.0 nM
CCc1c2c(nn1C(=O)N(C)C)C(=O)N(c1cc(C)c(=O)n(C)c1)C2c1ccc(Cl)cc1 CHEMBL3654279 IC50 160.0 nM
Cc1nn(C2CNC2)c2c1C(c1ccc(Cl)cc1)N(c1cc(C)c3nnc(C)n3c1)C2=O CHEMBL3654280 IC50 160.0 nM
Cc1cc(N2C(=O)c3nn(C)c(C)c3C2c2ccc(Cl)cc2)cn(C)c1=O CHEMBL3650880 IC50 160.0 nM
Cc1[nH]nc2c1C(c1ccc(Cl)cc1F)N(c1cc(C)c(=O)n(C)c1)C2=O CHEMBL3654319 IC50 170.0 nM
CC(=O)N1CCc2c(sc3nc(SCC(=O)Nc4cc(F)ccc4F)n(Cc4ccco4)c(=O)c23)C1 CHEMBL5074953 IC50 170.0 nM
CC(=O)c1cccc(NC(=O)CSc2nc3sc4c(c3c(=O)n2Cc2ccco2)CCN(C(C)=O)C4)c1 CHEMBL5072385 IC50 170.0 nM
Cc1c2c(nn1C)C(=O)N(c1cc(Cl)c(=O)n(C)c1)C2c1ccc(Cl)cc1 CHEMBL3650859 IC50 180.0 nM
Cn1cc(N2C(=O)c3n[nH]cc3C2c2ccc(Cl)cc2)cc(Cl)c1=O CHEMBL3650862 IC50 180.0 nM
CNC(=O)n1nc(C)c2c1C(=O)N(c1cc(C)c3nnc(C)n3c1)C2c1ccc(Cl)cc1 CHEMBL3654276 IC50 190.0 nM
COc1cc(OC)c2c(=O)[nH]c(-c3cc(C)c(OCCO)c(C)c3)nc2c1 CHEMBL2393130 Kd 190.0 nM
COc1cc2c(cc1-c1c(C)noc1C)ncc1[nH]c(=O)n([C@H](C)c3ccccc3)c12 CHEMBL2017288 pIC50 199.53 nM
Cc1nnc2c(NC3CCN(CC(C)(C)F)CC3)cc(C(=O)N3[C@@H]4c5ccccc5C[C@H]3C(=O)N[C@@H]4C(C)C)nn12 CHEMBL5079885 pKd 199.53 nM
COc1ccc(-c2c(C)noc2C)cc1S(=O)(=O)NC1CCCC1 CHEMBL2181722 IC50 200.0 nM
Cc1cc(N2C(=O)c3nn(C)c(O)c3C2c2ccc(Cl)cc2)cn(C)c1=O CHEMBL3650922 IC50 200.0 nM
CNC(=O)n1nc2c(c1C)C(c1ccc(Cl)cc1)N(c1cc(C)c3nnc(C)n3c1)C2=O CHEMBL3654277 IC50 200.0 nM
Cc1nn(C2CN(C)C2)c2c1C(c1ccc(Cl)cc1)N(c1cc(C)c3nnc(C)n3c1)C2=O CHEMBL3654286 IC50 200.0 nM
CC(=O)N1CCc2c(sc3nc(SCC(=O)Nc4ccccc4F)n(Cc4ccco4)c(=O)c23)C1 CHEMBL5089658 IC50 210.0 nM
CC(=O)N1CCc2c(sc3nc(SCC(=O)Nc4ccc(C)c(F)c4)n(Cc4ccco4)c(=O)c23)C1 CHEMBL5094390 IC50 210.0 nM
CC(=O)OC[C@]12CC[C@H]3[C@@H](C[C@H]4O[C@]45CC=CC(=O)[C@]35C)[C@]1(O)[C@@H](OC(C)=O)C[C@@]2(O)[C@@](C)(O)[C@H]1CC(C)=C(C)C(=O)O1 CHEMBL4074906 IC50 210.0 nM
Cc1cc(/N=N/c2ccc(S(=O)(=O)Nc3ccccn3)cc2)c(N)c(C)c1O CHEMBL3086884 Ki 220.0 nM
CC(=O)N1CCc2c(sc3nc(SCC(=O)Nc4ccccc4C)n(Cc4ccco4)c(=O)c23)C1 CHEMBL5077199 IC50 220.0 nM
CC(=O)OC[C@]12CC[C@H]3[C@@H](C[C@H]4O[C@]45CCCC(=O)[C@]35C)[C@]1(O)CC[C@@]2(O)[C@@](C)(O)[C@H]1CC(C)=C(C)C(=O)O1 CHEMBL4082632 IC50 235.0 nM
Cc1cc(/N=N/c2ccc(S(=O)(=O)Nc3ccccn3)cc2)c(N)c(Cl)c1O CHEMBL3086885 Ki 240.0 nM
Cc1nn(C2CNC2)c2c1C(c1ccc(Cl)cc1)N(c1cc(C)c(=O)n(C)c1)C2=O CHEMBL3654269 IC50 240.0 nM
COc1ccccc1S(=O)(=O)Nc1ccc2c3c(cc(-n4cnc(C)c4)nc13)C(=O)N2C CHEMBL4446421 IC50 246.3 nM
Cc1ccc(-c2c(C)noc2C)cc1S(=O)(=O)NC1CCCC1 CHEMBL2181721 IC50 250.0 nM
Cc1c2c(nn1C)C(=O)N(c1ccc3nnc(C)n3c1)C2c1ccc(Cl)cc1 CHEMBL3650878 IC50 250.0 nM
COc1cc2c(cc1-c1c(C)noc1C)ncc1[nH]c(=O)n(Cc3ccccc3)c12 CHEMBL2017285 pIC50 251.19 nM
CNC(=O)n1nc(C)c2c1C(=O)N(c1cc(C)c(=O)n(C)c1)C2c1ccc(Cl)cc1 CHEMBL3654274 IC50 270.0 nM
COc1ncc(-n2nc3c(c2C(F)(F)F)C(c2ccc(Cl)cc2)N(c2cc(Cl)c(=O)n(C)c2)C3=O)c(OC)n1 CHEMBL3650897 IC50 280.0 nM
CCc1nn(CCOCC(F)(F)F)c2c1C(c1ccc(Cl)cc1)N(c1cc(OC)c3nnc(C)n3c1)C2=O CHEMBL3650953 IC50 280.0 nM
Cn1cc(N2C(=O)c3c(c(C(F)(F)F)nn3C3CC3)C2c2ccc(Cl)cc2)cc(Cl)c1=O CHEMBL3650895 IC50 280.0 nM
Cc1nn(C)c2c1C(c1ccc(Cl)cc1)N(c1cc(Cl)c(=O)n(C)c1)C2=O CHEMBL3650907 IC50 290.0 nM
Cn1cc(-c2cc(S(C)(=O)=O)ccc2Oc2ccc(F)cc2F)c2cc[nH]c(=O)c21 CHEMBL4088466 Ki 290.0 nM
COc1ncc(-n2nc3c(c2C(C)C)C(c2ccc(Cl)cc2)N(c2ccc4onc(C)c4c2)C3=O)c(OC)n1 CHEMBL3650904 IC50 300.0 nM
COc1cccc(NC(=O)CSc2nc3sc4c(c3c(=O)n2Cc2ccco2)CCN(C(C)=O)C4)c1 CHEMBL5079297 IC50 300.0 nM
COc1cc2c(Nc3ccccc3F)c(C(N)=O)cnc2cc1-c1c(C)noc1C CHEMBL2017273 pIC50 316.23 nM
CC(=O)N1c2ccc(-c3ccc(CN4CCCCC4)cc3)cc2[C@H](Nc2ccccc2)C[C@@H]1C CHEMBL3353992 pIC50 316.23 nM
CC(=O)N1c2ccc(-c3ccc(C(=O)O)cc3)cc2[C@H](Nc2ccc(S(C)(=O)=O)cc2)C[C@@H]1C CHEMBL3353997 pIC50 316.23 nM
CCNC(=O)c1ccc(OCc2cccc(C)n2)c(-c2cn(C)nn2)c1 CHEMBL4856289 pIC50 316.23 nM
CC(=O)c1ccc(NC(=O)CSc2nc3sc4c(c3c(=O)n2Cc2ccco2)CCN(C(C)=O)C4)cc1 CHEMBL5086321 IC50 320.0 nM
Cc1[nH]nc2c1C(c1ccc(Cl)cc1)N(c1cc(Cl)c(=O)n(C)c1)C2=O CHEMBL3650858 IC50 370.0 nM
CC(=O)N1CCc2c(sc3nc(SCC(=O)Nc4ccc(F)cc4F)n(Cc4ccco4)c(=O)c23)C1 CHEMBL5075819 IC50 380.0 nM
CCc1c(C(=O)Nc2cc(S(=O)(=O)N(CC)CC)ccc2O)[nH]c(C)c1C(C)=O CHEMBL3787231 Kd 380.0 nM
COc1cc2c(cc1-c1c(C)noc1C)ncc1[nH]c(=O)n(-c3ccccc3C(C)(C)C)c12 CHEMBL2017283 pIC50 398.11 nM
CC(=O)N1c2ccc(-c3ccc(C(=O)O)cc3)cc2[C@H](Nc2ccccc2)C[C@@H]1C CHEMBL3352833 pIC50 398.11 nM
CC(=O)N1c2ccc(-c3cccc(CN4CCCCC4)c3)cc2[C@H](Nc2ccccc2)C[C@@H]1C CHEMBL3353991 pIC50 398.11 nM
CC(=O)N1c2ccc(-c3ccc(C(N)=O)cc3)cc2[C@H](Nc2ccc(Cl)cc2)C[C@@H]1C CHEMBL3354008 pIC50 398.11 nM
CC(=O)N1CCc2c(sc3nc(SCC(=O)Nc4cc(Cl)ccc4C)n(-c4ccc(C)o4)c(=O)c23)C1 CHEMBL5085041 IC50 410.0 nM
CSc1cccc(NC(=O)CSc2nc3sc4c(c3c(=O)n2Cc2ccco2)CCN(C(C)=O)C4)c1 CHEMBL5076502 IC50 410.0 nM
CC(=O)N1CCc2c(sc3nc(SCC(=O)Nc4ccc(F)cc4)n(Cc4ccco4)c(=O)c23)C1 CHEMBL5089846 IC50 420.0 nM
Cc1nn(C2CN(C)C2)c2c1C(c1ccc(Cl)cc1)N(c1cc(C)c(=O)n(C)c1)C2=O CHEMBL3654271 IC50 440.0 nM
CC(=O)N1CCc2c(sc3nc(SCC(=O)Nc4cccc(C)c4)n(Cc4ccco4)c(=O)c23)C1 CHEMBL5089257 IC50 440.0 nM
Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)NCCOCCOCCNC(=O)C1C(C(=O)O)C(C(=O)O)C1C(=O)O)c1nnc(C)n1-2 CHEMBL4474387 IC50 456.0 nM
Cc1c2c(nn1C)C(=O)N(c1cc(F)c(=O)n(C)c1)C2c1ccc(Cl)cc1 CHEMBL3650883 IC50 470.0 nM
CC(=O)N1CCc2c(sc3nc(SCC(=O)Nc4ccc(F)c(F)c4)n(Cc4ccco4)c(=O)c23)C1 CHEMBL5075514 IC50 470.0 nM
COc1nccc(-n2nc(C)c3c2C(=O)N(c2cc(C)c(=O)n(C)c2)C3c2ccc(Cl)cc2)n1 CHEMBL3650908 IC50 480.0 nM
CC(=O)N1CCc2c(sc3nc(SCC(=O)Nc4cccc(Cl)c4)n(Cc4ccco4)c(=O)c23)C1 CHEMBL5094939 IC50 490.0 nM
COc1cc2c(cc1-c1c(C)noc1C)ncc1[nH]c(=O)n(Cc3ccccn3)c12 CHEMBL2017286 pIC50 501.19 nM
COc1cc2c(NC3CCCCC3)c(C(N)=O)cnc2cc1-c1c(C)noc1C CHEMBL2017277 pIC50 501.19 nM
COc1cc2c(Nc3cccc4cccnc34)c(C(N)=O)cnc2cc1-c1c(C)noc1C CHEMBL2017281 pIC50 501.19 nM
Cc1noc(C)c1-c1ccc2c(Nc3ccccc3C(C)(C)C)c(C(=O)O)cnc2c1 CHEMBL2017269 pIC50 501.19 nM
CCOC(=O)N[C@@H]1N=C(c2ccccc2)c2ccccc2-n2c(C)nnc21 CHEMBL2430873 pIC50 501.19 nM
CC(=O)N1c2ccc(-c3ccccc3)cc2[C@H](Nc2ccccc2)C[C@@H]1C CHEMBL3353984 pIC50 501.19 nM
CC(=O)N1c2ccc(-c3ccc(CO)cc3)cc2[C@H](Nc2ccccc2)C[C@@H]1C CHEMBL3353989 pIC50 501.19 nM
COC(=O)c1ccc(-c2ccc3c(c2)[C@H](Nc2ccc(C(C)(C)C)cc2)C[C@H](C)N3C(C)=O)cc1 CHEMBL3353996 pIC50 501.19 nM
COC(=O)c1ccc(-c2ccc3c(c2)[C@H](Nc2ccc(S(C)(=O)=O)cc2)C[C@H](C)N3C(C)=O)cc1 CHEMBL3353998 pIC50 501.19 nM
COc1cccc(N[C@@H]2C[C@H](C)N(C(C)=O)c3ccc(-c4ccc(C(=O)O)cc4)cc32)c1 CHEMBL3354003 pIC50 501.19 nM
COc1ccccc1N[C@@H]1C[C@H](C)N(C(C)=O)c2ccc(-c3ccc(C(=O)O)cc3)cc21 CHEMBL3354004 pIC50 501.19 nM
CC(=O)N1c2ccc(-c3cccc(C(=O)O)c3)cc2[C@H](Nc2ccc(Cl)cc2)C[C@@H]1C CHEMBL3354006 pIC50 501.19 nM
CNC(=O)c1cccn(Cc2ccccc2)c1=O CHEMBL4633353 pIC50 501.19 nM
CN1C=C(c2ccc3ccn(Cc4ccccn4)c3c2)C2C=CNC2C1=O CHEMBL5205457 IC50 502.0 nM
Cc1c2c(nn1C)C(=O)N(c1ccc(=O)n(C)c1)C2c1ccc(Cl)cc1 CHEMBL3650856 IC50 520.0 nM
CC(=O)N1CCc2c(sc3nc(SCC(=O)Nc4ccc(Cl)cc4)n(Cc4ccco4)c(=O)c23)C1 CHEMBL5090901 IC50 530.0 nM
CO[C@H]1CC[C@H](n2c([C@@H]3CCCC(=O)N3c3ccc(F)c(F)c3)nc3cc(-c4c(C)noc4C)ccc32)CC1 CHEMBL4785363 Kd 560.0 nM
COc1ccc(NC(=O)CSc2nc3sc4c(c3c(=O)n2Cc2ccco2)CCN(C(C)=O)C4)cc1 CHEMBL5090190 IC50 570.0 nM
CC(=O)N1CCc2c(sc3nc(SCC(=O)Nc4ccc(C)cc4)n(Cc4ccco4)c(=O)c23)C1 CHEMBL5081830 IC50 630.0 nM
COc1cc2c(cc1-c1c(C)noc1C)ncc1[nH]c(=O)n([C@@H](C)c3ccccn3)c12 CHEMBL2181820 pIC50 630.96 nM
COc1cc2c(cc1-c1c(C)noc1C)ncc1[nH]c(=O)n([C@@H](C)c3ccccc3)c12 CHEMBL2017289 pIC50 630.96 nM
COc1cc2c(cc1-c1c(C)noc1C)ncc1[nH]c(=O)n(-c3ccccc3F)c12 CHEMBL2017282 pIC50 630.96 nM
Cc1noc(C)c1-c1ccc2c(Nc3ccccc3F)c(C(=O)O)cnc2c1 CHEMBL2181818 pIC50 630.96 nM
COc1ccc(-c2ccc3c(c2)[C@H](Nc2ccccc2)C[C@H](C)N3C(C)=O)cc1 CHEMBL3353988 pIC50 630.96 nM
CC(=O)N1c2ccc(-c3ccc(CN4CCOCC4)cc3)cc2[C@H](Nc2ccccc2)C[C@@H]1C CHEMBL3353990 pIC50 630.96 nM
CCN(C1CCCC1)S(=O)(=O)c1cc(-c2c(C)noc2C)ccc1OC CHEMBL2181704 IC50 700.0 nM
COc1ccc(-c2c(C)noc2C)cc1S(=O)(=O)N(C)C1CCCC1 CHEMBL2181703 IC50 700.0 nM
Cc1ccc(-c2c(C)noc2C)cc1S(=O)(=O)NC1CCCCC1 CHEMBL2181723 IC50 700.0 nM
CC1=C(C)C(=O)O[C@@H]([C@](C)(O)[C@]2(O)CC[C@@]3(O)[C@@H]4C[C@H]5O[C@]56CC=CC(=O)[C@]6(C)[C@H]4CC[C@]23C)C1 CHEMBL1097107 IC50 720.3 nM
CC1=C(CO)C[C@H]([C@](C)(O)[C@]2(O)CC[C@@]3(O)[C@@H]4C[C@H]5O[C@]56CC=CC(=O)[C@]6(C)[C@H]4CC[C@]23C)OC1=O CHEMBL5412959 IC50 736.0 nM
CC(=O)N1CCc2c(sc3nc(SCC(=O)Nc4ccc(F)c(Cl)c4)n(Cc4ccco4)c(=O)c23)C1 CHEMBL5074555 IC50 740.0 nM
CC(=O)OC[C@]12CC[C@H]3[C@@H](C[C@H]4O[C@]45CC=CC(=O)[C@]35C)[C@]1(O)CC[C@@]2(O)[C@@](C)(O)[C@H]1C[C@]2(C)O[C@]2(C)C(=O)O1 CHEMBL4075419 IC50 754.7 nM
Cc1cc(C)cc(Nc2nccc(-c3c(C)nnn3C3CCNCC3)n2)c1 CHEMBL4441390 IC50 770.0 nM
COc1ccc2c(c1)C(c1ccccc1)=NC(NC(=O)OCc1ccccc1)c1nnc(C)n1-2 CHEMBL2430892 pIC50 794.33 nM
Cc1nnc2n1-c1ccccc1C(c1ccccc1)=NC2NC(=O)NCc1ccccc1 CHEMBL2430886 pIC50 794.33 nM
CC(=O)N1c2ccc(-c3ccc(C#N)cc3)cc2[C@H](Nc2ccccc2)C[C@@H]1C CHEMBL3353985 pIC50 794.33 nM
CC(=O)N1c2ccc(-c3ccc(C#N)cc3)cc2[C@H](Nc2cccc(F)c2)C[C@@H]1C CHEMBL3354001 pIC50 794.33 nM
COc1cccc(N[C@@H]2C[C@H](C)N(C(C)=O)c3ccc(-c4ccc(C#N)cc4)cc32)c1 CHEMBL3354002 pIC50 794.33 nM
Cc1ccc(-c2c(C)noc2C)cc1S(=O)(=O)N1CCCCC1 CHEMBL2181706 IC50 800.0 nM
Cc1nn(C2CC2)c2c1C(c1cccc(C(F)(F)F)c1)N(c1cc(C)c(=O)n(C)c1)C2=O CHEMBL3650942 IC50 800.0 nM
CCOc1ccc(NC(=O)CSc2nc3sc4c(c3c(=O)n2Cc2ccco2)CCN(C(C)=O)C4)cc1 CHEMBL5076250 IC50 880.0 nM
Cc1c2c(nn1C)C(=O)N(c1ccc(=O)n(C)n1)C2c1ccc(Cl)cc1 CHEMBL3650884 IC50 890.0 nM
Cc1noc2ccc(N3C(=O)c4nn(C)c(C)c4C3c3ccc(Cl)cc3)cc12 CHEMBL3650885 IC50 920.0 nM
Cc1ccc(-c2c(C)noc2C)cc1S(=O)(=O)Nc1ccccc1 CHEMBL2181724 IC50 1000.0 nM
Cc1ccc(-c2c(C)noc2C)cc1S(=O)(=O)NC1CC1 CHEMBL2181719 IC50 1000.0 nM
CCOC(=O)NC1N=C(c2ccccc2)c2ccccc2-n2c(C)nnc21 CHEMBL2430871 pIC50 1000.0 nM
Cc1nnc2n1-c1ccccc1C(c1ccccc1)=NC2NC(=O)OCc1ccc(F)cc1 CHEMBL2430869 pIC50 1000.0 nM
Cc1ccc(C2=NC(NC(=O)OCc3ccccc3)c3nnc(C)n3-c3ccccc32)cc1 CHEMBL2430896 pIC50 1000.0 nM
COc1ccc(C2=NC(NC(=O)OCc3ccccc3)c3nnc(C)n3-c3ccccc32)cc1 CHEMBL2430895 pIC50 1000.0 nM
COc1cccc(C2=NC(NC(=O)OCc3ccccc3)c3nnc(C)n3-c3ccccc32)c1 CHEMBL2430894 pIC50 1000.0 nM
COC(=O)c1ccc(-c2ccc3c(c2)[C@H](Nc2ccccc2)C[C@H](C)N3C(C)=O)cc1 CHEMBL3353986 pIC50 1000.0 nM
COC(=O)c1ccc(-c2ccc3c(c2)[C@H](Nc2ccc(F)cc2)C[C@H](C)N3C(C)=O)cc1 CHEMBL3354000 pIC50 1000.0 nM
COC(=O)c1cccc(-c2ccc3c(c2)[C@H](Nc2ccc(Cl)cc2)C[C@H](C)N3C(C)=O)c1 CHEMBL3354007 pIC50 1000.0 nM
Cc1cncc(-c2ccc(N[C@@H]3CCNC[C@H]3OCC3CCS(=O)(=O)CC3)c3[nH]c(=O)c(C)cc23)c1 CHEMBL3590405 pKd 1000.0 nM
Cc1ccc(C(C)C)cc1Oc1nccc(-c2c(-c3ccc(C(F)(F)F)cc3)ncn2C2CCNCC2)n1 CHEMBL5084290 IC50 1000.0 nM