Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCCCCCCCNC(=O)c2cc3c(cc2CS(C)(=O)=O)C2=CC(C)C(=O)c4[nH]cc(c42)CN3c2ncc(F)cc2F)C(C)(C)C)cc1 CHEMBL5283914 DC50 0.03 nM
CCS(=O)(=O)Nc1ccc(OCCOCCOCCOCCOc2ccc(NS(=O)(=O)CC)cc2-c2cn(C)c(=O)c3ccccc23)c(-c2cn(C)c(=O)c3ccccc23)c1 CHEMBL5170488 Kd 0.095 nM
CCS(=O)(=O)Nc1cc(-c2cn(C)c3c(=O)[nH]ccc23)cc2c1ccn2C(C)(c1ccccn1)c1ccccn1 CHEMBL4648912 Kd 0.1 nM
COC(=O)CNC(=O)C[C@@H]1N=C(c2ccc(Cl)cc2)c2c(sc(C)c2C)-n2c(C)nnc21 CHEMBL5424952 IC50 0.1 nM
Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)NCCCCCNC(=O)COc1ccc(C3CCC(=O)NC3=O)cc1)c1nnc(C)n1-2 CHEMBL5281214 DC50 0.16 nM
Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)NCc1ccon1)c1nnc(C)n1-2 CHEMBL5440537 IC50 0.2 nM
Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)Nc1nncs1)c1nnc(C)n1-2 CHEMBL5432745 IC50 0.2 nM
Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)N/N=C/c1ncc[nH]1)c1nnc(C)n1-2 CHEMBL3895096 IC50 0.24 nM
CCS(=O)(=O)Nc1ccc(Oc2ccccc2)c(-c2cn(C)c(=O)c3[nH]ccc23)c1 CHEMBL3898684 Ki 0.25 nM
CC(=O)NCCCCn1c2c(c3ccccc31)C(=O)NCC2 CHEMBL3770724 Kd 0.3 nM
Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)NCc1ccccc1)c1nnc(C)n1-2 CHEMBL5401253 IC50 0.3 nM
Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)NCc1ncco1)c1nnc(C)n1-2 CHEMBL5440963 IC50 0.3 nM
C[C@H]1C(=O)N(C)C=Cc2cc(OCCCCOc3ccc4c(c3)C=CN(C)C(=O)[C@@H]4C)ccc21 CHEMBL5426022 pIC50 0.3162 nM
CCS(=O)(=O)Cc1ccc(Oc2ccc(F)cc2F)c(-c2cn(C)c(=O)c3cc(-c4cc(C)c(OCCO)c(C)c4)oc23)c1 CHEMBL5171062 IC50 0.33 nM
CCS(=O)(=O)Nc1ccc(Oc2ccc(F)cc2F)c(-c2cn(C)c(=O)c3cc(-c4cnc(C5CC5)[nH]4)oc23)c1 CHEMBL5206375 IC50 0.34 nM
Cc1cc(-c2cc3c(=O)n(C)cc(-c4cc(NS(C)(=O)=O)ccc4Oc4ccc(F)cc4F)c3o2)cc(C)c1OCCO CHEMBL5171510 IC50 0.39 nM
Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCCOCCNC(=O)C[C@@H]2N=C(c3ccc(Cl)cc3)c3c(sc(C)c3C)-n3c(C)nnc32)C(C)(C)C)cc1 CHEMBL4215078 DC50 0.39 nM
CC(=O)N1c2ccc(-c3ccc(C(=O)O)cc3)cc2[C@H](Nc2ccc(Cl)cc2)C[C@@H]1C CHEMBL2177300 pIC50 0.3981 nM
[2H]C([2H])([2H])c1nnn(C)c1-c1cc2c(cc1F)c1ncc(C(C)(C)O)cc1n2[C@H](c1ccccc1)C1CCOCC1 CHEMBL5091333 IC50 0.4 nM
COc1cc(OC)c2c(=O)[nH]c(-c3cc(C)c(OCCOc4ccccc4C(N)=O)c(C)c3)nc2c1 CHEMBL5209870 IC50 0.4 nM
Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)NCC(=O)O)c1nnc(C)n1-2 CHEMBL5422881 IC50 0.4 nM
CCS(=O)(=O)Nc1ccc(Oc2ccc(F)cc2F)c(-c2cn(C)c(=O)c3cc(-c4ccc(CCCO)cc4)oc23)c1 CHEMBL5171031 IC50 0.41 nM
COC(=O)c1ccc(N[C@@H]2C[C@H](C)N(C(C)=O)c3ccc(-c4cccc(NC(C)=O)c4)cc32)cc1 CHEMBL5269983 IC50 0.42 nM
Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)NCCc1cnc[nH]1)c1nnc(C)n1-2 CHEMBL3932024 IC50 0.427 nM
Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)OCCCCCCO)c1nnc(C)n1-2 CHEMBL4077038 Kd 0.43 nM
CCS(=O)(=O)Nc1ccc(Oc2c(F)cc(F)cc2F)c(-c2cn(C)c(=O)c3cc(-c4cc(C)c(OCCO)c(C)c4)oc23)c1 CHEMBL5176955 IC50 0.43 nM
Cc1cc(-c2cc3c(=O)n(C)cc(-c4cc(C(C)(C)O)ccc4Oc4ccc(F)cc4F)c3o2)cc(C)c1OCCO CHEMBL5177436 IC50 0.45 nM
Cn1cc(-c2cc(S(C)(=O)=O)ccc2OC2CCCCC2)c2cc[nH]c2c1=O CHEMBL3979505 Ki 0.46 nM
Cc1cc(F)cc(C)c1Oc1ccc(C(C)(C)O)cc1-c1cn(C)c(=O)c2cc(-c3cnc(C4CCOCC4)[nH]3)oc12 CHEMBL5192071 IC50 0.46 nM
CCS(=O)(=O)Nc1ccc(Oc2ccc(F)cc2F)c(-c2cn(C)c(=O)c3cc(-c4cc(C)c(CCCO)c(C)c4)oc23)c1 CHEMBL5175082 IC50 0.49 nM
Cn1cc(-c2cc(NS(=O)(=O)CC(F)(F)F)ccc2OC2CCCOC2)c2cc[nH]c2c1=O CHEMBL3926639 Ki 0.5 nM
Cn1cc(-c2cc(NS(C)(=O)=O)ccc2Oc2ccccc2)c2cc(C(N)=O)[nH]c2c1=O CHEMBL3969291 Ki 0.5 nM
COc1cc2c(cc1-c1c(C)noc1C)[nH]c1nc(C)nc(Nc3cc(C)nn3C(C)C)c12 CHEMBL4166630 Ki 0.5 nM
CCn1nc(C2CC2)cc1Nc1nc(C(=O)NC)nc2[nH]c3cc(-c4c(C)noc4C)c(OC)cc3c12 CHEMBL4228445 Ki 0.5 nM
CCNC(=O)c1cc2c(-c3cc(NC(C)=O)ccc3Oc3c(C)cccc3C)cn(C)c(=O)c2[nH]1 CHEMBL4435166 Ki 0.5 nM
Cc1cc(F)cc(C)c1Oc1ccc(C(C)(C)O)cc1-c1cn(C)c(=O)c2[nH]c(C(=O)NC3CC3)cc12 CHEMBL4555714 Ki 0.5 nM
CCNC(=O)c1cc2c(-c3cc(S(=O)(=O)CC)ccc3N3CCc4cccc(C)c43)cn(C)c(=O)c2[nH]1 CHEMBL4465299 Ki 0.5 nM
CCNC(=O)c1cc2c(-c3cc(S(=O)(=O)CC)ccc3Oc3ccccc3Cl)cn(C)c(=O)c2[nH]1 CHEMBL4548794 Ki 0.5 nM
[2H]C([2H])([2H])c1nnn(C)c1-c1cc2c(cc1F)c1ncc(C(C)(C)O)cc1n2[C@@H](CCC)c1ncccc1F CHEMBL5075294 IC50 0.5 nM
CCc1ncc(-c2cc3c(=O)n(C)cc(-c4cc(NS(=O)(=O)CC)ccc4Oc4ccc(F)cc4F)c3o2)[nH]1 CHEMBL5172345 IC50 0.5 nM
C[C@H]1C(=O)N(C)C=Cc2cc(CN3CCN(Cc4ccc5c(c4)C=CN(C)C(=O)[C@@H]5C)CC3)ccc21 CHEMBL5433432 pIC50 0.5012 nM
Cn1cc(-c2cc(CN3CCCS3(=O)=O)ccc2Oc2ccccc2)c2cc[nH]c2c1=O CHEMBL3921115 Ki 0.51 nM
CCS(=O)(=O)Nc1ccc(Oc2ccc(F)cc2F)c(-c2cn(C)c(=O)c3cc(-c4cnc[nH]4)oc23)c1 CHEMBL5209398 IC50 0.51 nM
CCS(=O)(=O)Nc1ccc(OC2CCCOC2)c(-c2cn(C)c(=O)c3[nH]ccc23)c1 CHEMBL3928904 Ki 0.52 nM
CC(=O)Nc1ccc(Oc2ccc(F)cc2F)c(-c2cn(C)c(=O)c3cc(-c4cc(C)c(OCCO)c(C)c4)oc23)c1 CHEMBL5202705 IC50 0.52 nM
Cc1cc(F)cc(C)c1Oc1ccc(C(C)(C)O)cc1-c1cn(C)c(=O)c2cc(-c3cnc(C4CCC4)[nH]3)oc12 CHEMBL5205742 IC50 0.52 nM
CCS(=O)(=O)Nc1ccc(Oc2ccc(F)cc2F)c(-c2cn(C)c(=O)c3cc(-c4cnc(C)[nH]4)oc23)c1 CHEMBL5171591 IC50 0.53 nM
CCS(=O)(=O)Nc1ccc(Oc2ccc(F)cc2F)c(-c2cn(C)c(=O)c3cc(-c4cnc(C(C)C)[nH]4)oc23)c1 CHEMBL5199360 IC50 0.54 nM
CCS(=O)(=O)Nc1ccc(Oc2ccc(F)cc2F)c(-c2cn(C)c(=O)c3cc(-c4cc(C)c(OCCO)c(C)c4)oc23)c1 CHEMBL5200542 IC50 0.56 nM
CCS(=O)(=O)Nc1ccc(Oc2ccc(F)cc2F)c(-c2cn(C)c(=O)c3cc(-c4ccc(OCCO)cc4)oc23)c1 CHEMBL5184079 IC50 0.56 nM
CCS(=O)(=O)c1ccc(OC2CCC(C)(OC)CC2)c(-c2cn(C)c(=O)c3[nH]ccc23)c1 CHEMBL3906254 Ki 0.57 nM
Cc1cc(-c2cc3c(=O)n(C)cc(-c4cc(CS(=O)(=O)C(C)C)ccc4Oc4ccc(F)cc4F)c3o2)cc(C)c1OCCO CHEMBL5191078 IC50 0.57 nM
Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)NCCN1CCN(C)CC1)c1nnc(C)n1-2 CHEMBL3900452 IC50 0.5843 nM
Cc1cc(F)cc(C)c1Oc1ccc(C(C)(C)O)cc1-c1cn(C)c(=O)c2cc(-c3cnc(C4CC4)[nH]3)oc12 CHEMBL5178480 IC50 0.59 nM
CCS(=O)(=O)Nc1ccc(Oc2ccc(F)cc2F)c(-c2cn(C)c(=O)c3[nH]c(C#CCOC)cc23)c1 CHEMBL4104956 Ki 0.6 nM
CC(=O)Nc1ccc(CNc2cccc(Oc3ccc(S(C)(=O)=O)cc3-c3cn(C)c(=O)c4[nH]ccc34)c2)cc1 CHEMBL4078267 Ki 0.6 nM
CCNC(=O)c1cc2c(-c3cc(C(C)(C)O)ccc3Oc3c(C)cccc3C)cn(C)c(=O)c2[nH]1 CHEMBL4467038 Ki 0.6 nM
CCNC(=O)c1cc2c(-c3cc(S(=O)(=O)C4CC4)ccc3Oc3c(C)cccc3C)cn(C)c(=O)c2[nH]1 CHEMBL4564879 Ki 0.6 nM
[2H]C([2H])([2H])c1nnn(C)c1-c1cnc2c3ccc(C(C)(C)O)c(F)c3n([C@H](c3ncccc3F)C3CCOCC3)c2c1 CHEMBL4846895 IC50 0.6 nM
Cc1nnn(C)c1-c1ccc2c3ncc(C(C)(C)O)cc3n([C@H](c3ccccc3)C3CCOCC3)c2c1 CHEMBL5089688 IC50 0.6 nM
[2H]C([2H])([2H])c1nnn(C)c1-c1cc2c(cc1F)c1ncc(C(C)(C)O)cc1n2[C@H](c1ncccc1F)C1CCOCC1 CHEMBL5084198 IC50 0.6 nM
[2H]C([2H])([2H])c1nnn(C)c1-c1cc2c(cc1F)c1ncc(C(C)(C)O)cc1n2[C@H](c1cc(C)on1)C1CCOCC1 CHEMBL5090513 IC50 0.6 nM
CCc1ncc(-c2cc3c(=O)n(C)cc(-c4cc(C(C)(C)O)ccc4Oc4c(C)cc(F)cc4C)c3o2)[nH]1 CHEMBL5180474 IC50 0.6 nM
Cc1cc(F)cc(C)c1Oc1ccc(C(C)(C)O)cc1-c1cn(C)c(=O)c2cc(-c3cnc(C4CCOC4)[nH]3)oc12 CHEMBL5186717 IC50 0.6 nM
Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)NCc1cn(C)cn1)c1nnc(C)n1-2 CHEMBL5403848 IC50 0.6 nM
Cn1cc2c3c(c[nH]c3c1=O)CN(c1ccccn1)c1ccc(CS(C)(=O)=O)cc1-2 CHEMBL4208129 Ki 0.62 nM
Cn1cc(-c2cc(S(N)(=O)=O)cnc2NC2CCCCC2)c2cc[nH]c2c1=O CHEMBL3910575 Ki 0.63 nM
COCc1nc2cnc3cc(-c4c(C)noc4C)c(OC[C@H]4CCNC4)cc3c2n1[C@H](C)c1ccccc1 CHEMBL4639128 Kd 0.63 nM
C[C@H]1C(=O)N(C)C=Cc2cc(OCCOc3ccc4c(c3)C=CN(C)C(=O)[C@@H]4C)ccc21 CHEMBL5422047 pIC50 0.631 nM
C[C@H]1C(=O)N(C)C=Cc2cc(OCCCCCOc3ccc4c(c3)C=CN(C)C(=O)[C@@H]4C)ccc21 CHEMBL5403564 pIC50 0.631 nM
CCS(=O)(=O)Nc1ccc(Oc2ccc(C(N)=O)cc2)c(-c2cn(C)c(=O)c3[nH]ccc23)c1 CHEMBL3890504 Ki 0.65 nM
CCCS(=O)(=O)Nc1ccc(Oc2ccc(F)cc2F)c(-c2cn(C)c(=O)c3cc(-c4cc(C)c(OCCO)c(C)c4)oc23)c1 CHEMBL5206261 IC50 0.65 nM
CCNC(=O)c1cc2c(-c3cc(C(C)(C)O)ccc3Oc3c(C)cc(F)cc3C)cn(C)c(=O)c2[nH]1 CHEMBL4297454 IC50 0.65 nM
Cn1cc(-c2cc(CO)ccc2Oc2ccccc2)c2cc[nH]c2c1=O CHEMBL3943998 Ki 0.68 nM
Cc1cc(F)cc(C)c1Oc1ccc(C(C)(C)O)cc1-c1cn(C)c(=O)c2cc(-c3cnc(C(C)C)[nH]3)oc12 CHEMBL5173426 IC50 0.68 nM
CCS(=O)(=O)c1ccc(O[C@H]2CC[C@H](O)CC2)c(-c2cn(C)c(=O)c3[nH]ccc23)c1 CHEMBL3924615 Ki 0.69 nM
Cn1cc2c3c(c[nH]c3c1=O)CN(c1ncc(F)cc1F)c1ccc(CS(C)(=O)=O)cc1-2 CHEMBL3785440 IC50 0.7 nM
COc1cc2c(cc1-c1c(C)noc1C)[nH]c1nc(C)nc(Nc3nn(C)c4ccccc34)c12 CHEMBL4174669 Ki 0.7 nM
COc1cc2c(cc1-c1c(C)noc1C)[nH]c1ncnc(-c3c(C)[nH]c4ccccc34)c12 CHEMBL4208405 Ki 0.7 nM
CCNC(=O)c1cc2c(-c3cc(S(=O)(=O)CC)ccc3Oc3ccc(F)cc3F)cn(C)c(=O)c2[nH]1 CHEMBL4454597 Ki 0.7 nM
CCNC(=O)c1cc2c(-c3cc(S(=O)(=O)CC)ccc3Oc3cc(C)cc(C)c3)cn(C)c(=O)c2[nH]1 CHEMBL4461291 Ki 0.7 nM
Cc1nnn(C)c1-c1cc(F)c2c3ncc(C(C)(C)O)cc3n([C@H](c3ccccc3)C3CCOCC3)c2c1 CHEMBL5090808 IC50 0.7 nM
Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)OCC(C)(COCCOCCOCCNC(=O)C[C@@H]2N=C(c3ccc(Cl)cc3)c3c(sc(C)c3C)-n3c(C)nnc32)COCCOCCOCCNC(=O)C[C@@H]2N=C(c3ccc(Cl)cc3)c3c(sc(C)c3C)-n3c(C)nnc32)C(C)(C)C)cc1 CHEMBL5279987 DC50 0.7 nM
CCS(=O)(=O)Nc1ccc(Oc2ccc(F)cc2F)c(-c2cn(C)c(=O)c3[nH]ccc23)c1 CHEMBL3987016 IC50 0.7 nM
Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)NCc1ccccn1)c1nnc(C)n1-2 CHEMBL5436475 IC50 0.7 nM
CCS(=O)(=O)Nc1ccc(OC2CCOCC2)c(-c2cn(C)c(=O)c3[nH]ccc23)c1 CHEMBL3904365 Ki 0.72 nM
CCC(=O)Nc1ccc(Oc2ccc(F)cc2F)c(-c2cn(C)c(=O)c3cc(-c4cc(C)c(OCCO)c(C)c4)oc23)c1 CHEMBL5190094 IC50 0.72 nM
Cn1cc2c3c(c[nH]c3c1=O)CN(c1ccc(F)cc1F)c1ccc(CS(C)(=O)=O)cc1-2 CHEMBL4217457 Ki 0.73 nM
CCS(=O)(=O)Nc1ccc(OC2CCOC2)c(-c2cn(C)c(=O)c3[nH]ccc23)c1 CHEMBL3947850 Ki 0.74 nM
Cn1cc(-c2cc(NS(C)(=O)=O)ccc2OC2CCCOC2)c2cc[nH]c2c1=O CHEMBL3942527 Ki 0.75 nM
Cn1cc(-c2cc(NS(C)(=O)=O)cnc2Oc2ccccc2)c2cc[nH]c2c1=O CHEMBL3889757 Ki 0.75 nM
Cn1cc(-c2cc(S(N)(=O)=O)ccc2NCC2CC2)c2cc[nH]c2c1=O CHEMBL3953827 Ki 0.78 nM
CCS(=O)(=O)c1ccc(OC2CCC3(CC2)OCCO3)c(-c2cn(C)c(=O)c3[nH]ccc23)c1 CHEMBL3978548 Ki 0.79 nM
Cc1cc(F)cc(C)c1Oc1ccc(C(C)(C)O)cc1-c1cn(C)c(=O)c2cc(-c3cnc(C4CCCC4)[nH]3)oc12 CHEMBL5206088 IC50 0.79 nM
CCS(=O)(=O)Nc1ccc(Oc2ccc(F)cc2F)c(-c2cn(C)c(=O)c3[nH]c(CN4CCN(C)CC4)cc23)c1 CHEMBL3939053 Ki 0.8 nM
CCS(=O)(=O)Nc1cnc2c(c1)-c1cn(C)c(=O)cc1OCCCCc1cc(F)cc(F)c1O2 CHEMBL4068431 Ki 0.8 nM
COc1cc2c(cc1-c1c(C)noc1C)[nH]c1nc(C)nc(Nc3cc(C)nn3C)c12 CHEMBL4172277 Ki 0.8 nM
COc1cc2c(cc1-c1c(C)noc1C)[nH]c1nc(C)nc(-c3c(C)[nH]c4ccccc34)c12 CHEMBL4164015 Ki 0.8 nM
COc1cc2c(cc1-c1c(C)noc1C)[nH]c1nc(C)nc(Nc3cc(C4CC4)nn3C)c12 CHEMBL4173488 Kd 0.8 nM
CCNC(=O)c1cc2c(-c3cc(S(=O)(=O)CC)ccc3Oc3ccccc3C)cn(C)c(=O)c2[nH]1 CHEMBL4470856 Ki 0.8 nM
CCNC(=O)c1cc2c(-c3cc(NS(=O)(=O)CC)ccc3Oc3c(C)cccc3C)cn(C)c(=O)c2[nH]1 CHEMBL4529861 Ki 0.8 nM
CCNC(=O)c1cc2c(-c3cc(S(=O)(=O)CC)ccc3Oc3c(C)cc(Cl)cc3C)cn(C)c(=O)c2[nH]1 CHEMBL4548127 Ki 0.8 nM
Cc1nnn(C)c1-c1cnc2c3ccc(C(C)(C)O)cc3n([C@H](c3ccccc3)C3CCOCC3)c2c1 CHEMBL4297458 IC50 0.8 nM
COc1cc2c3ncc(-c4c(C)nnn4C)cc3n([C@H](c3ccccc3)C3CCOCC3)c2cc1C(C)(C)O CHEMBL5207310 IC50 0.8 nM
CCS(=O)(=O)Nc1ccc(Oc2c(C)cc(F)cc2C)c(-c2cn(C)c(=O)c3cc(-c4cc(C)c(OCCO)c(C)c4)oc23)c1 CHEMBL5176176 IC50 0.8 nM
CCOC(=O)c1cc2c(-c3cc(NS(C)(=O)=O)ccc3Oc3ccccc3)cn(C)c(=O)c2[nH]1 CHEMBL3974497 Ki 0.81 nM
Cn1cc(-c2cc(S(N)(=O)=O)ccc2OCC2CC2)c2cc[nH]c2c1=O CHEMBL3914979 Ki 0.83 nM
Cn1cc(-c2cc(NS(C)(=O)=O)ccc2OC2CCC(F)(F)CC2)c2cc[nH]c2c1=O CHEMBL3911104 Ki 0.84 nM
CCS(=O)(=O)c1ccc(NCC2CC2)c(-c2cn(C)c(=O)c3[nH]ccc23)c1 CHEMBL3907558 Ki 0.86 nM
CCS(=O)(=O)Nc1ccc(Oc2ccc(F)cc2F)c(-c2cn(C)c(=O)c3[nH]c(C(=O)N4CCN(C)CC4)cc23)c1 CHEMBL3941894 Ki 0.86 nM
CCS(=O)(=O)c1ccc(OC2CCC(F)(F)CC2)c(-c2cn(C)c(=O)c3[nH]ccc23)c1 CHEMBL3945636 Ki 0.86 nM
Cn1cc2c3c(c[nH]c3c1=O)CN(c1ccc(F)cc1)c1ccc(CS(C)(=O)=O)cc1-2 CHEMBL4212498 Ki 0.87 nM
Cn1cc(-c2cc(NS(C)(=O)=O)ccc2OC2CCCCC2)c2cc[nH]c2c1=O CHEMBL3948433 Ki 0.88 nM
COc1cc2c(cc1-c1c(C)noc1C)[nH]c1ncnc(-c3c(C)[nH]c4ccc(F)cc34)c12 CHEMBL4214978 Ki 0.9 nM
CCNC(=O)c1cc2c(-c3cc(S(=O)(=O)CC)ccc3-c3cccc4cc[nH]c34)cn(C)c(=O)c2[nH]1 CHEMBL4560574 Ki 0.9 nM
CCNC(=O)c1cc2c(-c3cc(S(=O)(=O)CC)ccc3Oc3c(C)cccc3Cl)cn(C)c(=O)c2[nH]1 CHEMBL4469571 Ki 0.9 nM
CCNC(=O)c1cc2c(-c3cc(S(=O)(=O)CC)ccc3Oc3c(C)cccc3F)cn(C)c(=O)c2[nH]1 CHEMBL4454614 Ki 0.9 nM
[2H]C([2H])([2H])c1nnn(C)c1-c1cnc2c3cc(F)c(C(C)(C)O)cc3n([C@H](c3ccccc3)C3CCOCC3)c2c1 CHEMBL4859923 IC50 0.9 nM
[2H]C([2H])([2H])c1nnn(C)c1-c1cnc2c3ccc(C(C)(C)O)cc3n([C@H](c3ncccc3F)C3CCOCC3)c2c1 CHEMBL4848871 IC50 0.9 nM
Cc1nnn(C)c1-c1cnc2c3ccc(S(C)(=O)=O)cc3n([C@H](c3ccccc3)C3CCOCC3)c2c1 CHEMBL5204989 IC50 0.9 nM
CCS(=O)(=O)Nc1ccc(Oc2ccc(F)cc2F)c(-c2cn(C)c(=O)c3cc(-c4cnc(C5CCCC5)[nH]4)oc23)c1 CHEMBL5205435 IC50 0.91 nM
CCS(=O)(=O)Nc1ccc(Oc2ccc(F)cc2F)c(-c2cn(C)c(=O)cc2OCc2ccccc2)c1 CHEMBL5199676 IC50 0.92 nM
CCS(=O)(=O)c1ccc2c(c1)-c1cn(C)c(=O)cc1OCCCCc1cc(Cl)ccc1O2 CHEMBL4075567 IC50 0.93 nM
Cc1cc(-c2cc3c(=O)n(C)cc(-c4cc(NS(=O)(=O)C(C)C)ccc4Oc4ccc(F)cc4F)c3o2)cc(C)c1OCCO CHEMBL5196207 IC50 0.94 nM
CCS(=O)(=O)Nc1ccc(Oc2ccc(F)cc2F)c(-c2cn(C)c(=O)c3cc(-c4cnc(C5CCC5)[nH]4)oc23)c1 CHEMBL5173301 IC50 0.94 nM
Cc1cc(-c2cc3c(=O)n(C)cc(-c4cc(CO)ccc4Oc4ccc(F)cc4F)c3o2)cc(C)c1OCCO CHEMBL5189967 IC50 0.98 nM
CCNC(=O)c1cc2c(-c3cc(NS(C)(=O)=O)ccc3Oc3ccccc3)nn(C)c(=O)c2[nH]1 CHEMBL3950858 Ki 0.99 nM
Cn1cc2c3c(c[nH]c(=O)c31)CN(c1ccccn1)c1ccc(CS(C)(=O)=O)cc1-2 CHEMBL3786682 IC50 1.0 nM
CCS(=O)(=O)c1ccc(O[C@H]2CC[C@H](OC)CC2)c(-c2cn(C)c(=O)c3[nH]ccc23)c1 CHEMBL3914034 Ki 1.0 nM
CN(C)S(=O)(=O)Nc1ccc(Oc2ccccc2)c(-c2cn(C)c(=O)c3[nH]ccc23)c1 CHEMBL3898479 Ki 1.0 nM
COc1cc2c(cc1-c1c(C)noc1C)[nH]c1nc(C)nc(Nc3nn(CCO)c4ccccc34)c12 CHEMBL4164393 Ki 1.0 nM
CNC(=O)c1cc2c(-c3cc(C(C)(C)O)ccc3Oc3c(C)cc(F)cc3C)cn(C)c(=O)c2[nH]1 CHEMBL4552305 Ki 1.0 nM
CCNC(=O)c1cc2c(-c3cc(S(=O)(=O)CC)ccc3Oc3c(C)cccc3Br)cn(C)c(=O)c2[nH]1 CHEMBL4434761 Ki 1.0 nM
Cc1nnc2c(NC(C)C)nc(-c3nc4cnc(N5CCOCC5)cc4n3Cc3ccc(F)cn3)cn12 CHEMBL3930178 IC50 1.0 nM
[2H]C([2H])([2H])c1nnn(C)c1-c1cnc2c3ccc(C(C)(C)O)cc3n([C@H](c3ccc(Cl)cn3)C3CCOCC3)c2c1 CHEMBL4864173 IC50 1.0 nM
CNC(=O)c1cc(C(=O)N[C@H]2[C@@H]3C[C@@H](O)C[C@@H]32)cc2c1OC[C@@]2(C)c1ccccc1 CHEMBL4869149 pIC50 1.0 nM
Cc1noc(C)c1-c1cc(C(N)=O)c2c3ccc(C(C)(C)O)cc3n([C@H](c3ccccc3)C3CCOCC3)c2c1 CHEMBL5080354 IC50 1.0 nM
[2H]C([2H])([2H])c1nnn(C)c1-c1cnc2c3c(OC)cc(C(C)(C)O)cc3n([C@H](c3ccccc3)C3CCOCC3)c2c1 CHEMBL5209351 IC50 1.0 nM
[2H]C([2H])([2H])c1nnn(C)c1-c1cnc2c3ccc(C(C)(C)O)c(F)c3n([C@H](c3ccccc3)C3CCOCC3)c2c1 CHEMBL4077176 IC50 1.0 nM
Cc1cc(-c2cc3c(=O)n(C)cc(-c4cc(NS(=O)(=O)C5CC5)ccc4Oc4ccc(F)cc4F)c3o2)cc(C)c1OCCO CHEMBL5174374 IC50 1.0 nM
Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2[C@@H](F)[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCOCCOCCNC(=O)C[C@@H]2N=C(c3ccc(Cl)cc3)c3c(sc(C)c3C)-n3c(C)nnc32)C(C)(C)C)cc1 CHEMBL4443814 DC50 1.0 nM
Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)NCc1c[nH]nn1)c1nnc(C)n1-2 CHEMBL5422163 IC50 1.0 nM
Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)Nc1nccs1)c1nnc(C)n1-2 CHEMBL5439607 IC50 1.0 nM
C[C@H]1C(=O)N(C)C=Cc2cc(OCCCCCCCOc3ccc4c(c3)C=CN(C)C(=O)[C@@H]4C)ccc21 CHEMBL5408181 pIC50 1.0 nM
Cn1cc(-c2cc(NS(C)(=O)=O)ccc2OC2CCOCC2)c2cc[nH]c2c1=O CHEMBL3926000 Ki 1.1 nM
CCNC(=O)c1cc2c(-c3cc(NS(C)(=O)=O)ccc3Oc3ccccc3)cn(C)c(=O)c2[nH]1 CHEMBL3945077 Ki 1.1 nM
Cn1cc(-c2cc(S(N)(=O)=O)ccc2Oc2ccccc2)c2cc[nH]c2c1=O CHEMBL3980661 Ki 1.1 nM
Cn1cc(-c2cc(S(C)(=O)=O)ccc2NC2CCCCC2)c2cc[nH]c2c1=O CHEMBL3907052 Ki 1.1 nM
Cn1cc(-c2cc(S(C)(=O)=O)ccc2N[C@H]2CC[C@H](NCc3ccc4ccccc4c3)CC2)c2cc[nH]c2c1=O CHEMBL4096313 Ki 1.1 nM
COc1cc2c(cc1-c1c(C)noc1C)[nH]c1ncnc(-c3c[nH]c4ccccc34)c12 CHEMBL4209113 Ki 1.1 nM
CCNC(=O)c1cc2c(-c3cc(NS(=O)(=O)CC)ccc3Oc3c(C)cc(F)cc3C)cn(C)c(=O)c2[nH]1 CHEMBL4466931 Ki 1.1 nM
CCNC(=O)c1cc2c(-c3cc(C4(O)COC4)ccc3Oc3c(C)cc(F)cc3C)cn(C)c(=O)c2[nH]1 CHEMBL4587188 Ki 1.1 nM
CCNC(=O)c1cc2c(-c3cc(S(=O)(=O)CC)ccc3-n3ccc4cccc(C)c43)cn(C)c(=O)c2[nH]1 CHEMBL4443563 Ki 1.1 nM
CCNC(=O)c1cc2c(-c3cc(S(=O)(=O)CC)ccc3Oc3c(C)cccc3C)cn(C)c(=O)c2[nH]1 CHEMBL4462804 Ki 1.1 nM
Cc1cccc(C)c1Oc1ccc(C(C)(C)O)cc1-c1cn(C)c(=O)c2[nH]c(C(=O)NC(C)(C)C)cc12 CHEMBL4442074 Ki 1.1 nM
CCNC(=O)c1cc2c(-c3cc(NC(C)=O)ccc3Oc3c(C)cc(F)cc3C)cn(C)c(=O)c2[nH]1 CHEMBL4461289 Ki 1.1 nM
CCNC(=O)c1cc2c(-c3cc(S(N)(=O)=O)ccc3Oc3c(C)cccc3C)cn(C)c(=O)c2[nH]1 CHEMBL4471851 Ki 1.1 nM
CCNC(=O)c1cc2c(-c3cc(S(=O)(=O)CC)ccc3-c3ccccc3C)cn(C)c(=O)c2[nH]1 CHEMBL4539875 Ki 1.1 nM
[2H]C([2H])([2H])c1nnn(C)c1-c1cnc2c3ccc(C(C)(C)O)c(Cl)c3n([C@H](c3ccccc3)C3CCOCC3)c2c1 CHEMBL5206537 IC50 1.1 nM
CCS(=O)(=O)Nc1ccc(OC2CCC(F)(F)CC2)c(-c2cn(C)c(=O)c3[nH]ccc23)c1 CHEMBL3943316 Ki 1.2 nM
CCS(=O)(=O)c1ccc(OC2CCSCC2)c(-c2cn(C)c(=O)c3[nH]ccc23)c1 CHEMBL3927729 Ki 1.2 nM
CN(C)S(=O)(=O)c1ccc(OCC2CC2)c(-c2cn(C)c(=O)c3[nH]ccc23)c1 CHEMBL3939648 Ki 1.2 nM
Cn1cc(-c2cc(N3CCCS3(=O)=O)ccc2Oc2ccc(F)cc2F)c2cc[nH]c2c1=O CHEMBL3922345 Ki 1.2 nM
Cn1cc(-c2cc(S(C)(=O)=O)ccc2OC2CCCCCC2)c2cc[nH]c2c1=O CHEMBL3982329 Ki 1.2 nM
CCNC(=O)c1cc2c(-c3cc(S(C)(=O)=O)ccc3Oc3ccc(F)cc3F)cn(C)c(=O)c2[nH]1 CHEMBL3915707 Ki 1.2 nM
CCS(=O)(=O)Nc1cc(-c2cn(C)c(=O)c3[nH]ccc23)c(Oc2ccc(F)cc2F)cc1C#N CHEMBL3925425 Ki 1.2 nM
COc1cc2c(cc1-c1c(C)noc1C)[nH]c1nc(C)nc(Nc3cc(C(C)(C)C)nn3C)c12 CHEMBL4162784 Ki 1.2 nM
Cn1cc2c3c(c[nH]c(=O)c31)-c1cc(CS(C)(=O)=O)ccc1N(c1ccc(F)cc1)C2 CHEMBL4215988 Ki 1.2 nM
CCNC(=O)c1cc2c(-c3cc(C4(O)CCOCC4)ccc3Oc3c(C)cc(F)cc3C)cn(C)c(=O)c2[nH]1 CHEMBL4455576 Ki 1.2 nM
Cn1cc(-c2cc(S(C)(=O)=O)ccc2Oc2ccc(F)cc2F)c2cc(C(N)=O)[nH]c2c1=O CHEMBL3964225 Ki 1.2 nM
CCNC(=O)c1cc2c(-c3cc(S(C)(=O)=O)ccc3Oc3c(C)cccc3C)cn(C)c(=O)c2[nH]1 CHEMBL4483338 Ki 1.2 nM
CC[C@@H]1C(=O)N(C)c2cnc(Nc3ccc(C(=O)NC4CCN(C)CC4)cc3OC)nc2N1C1CCCC1 CHEMBL513909 IC50 1.2 nM
Cc1cc(F)cc(C)c1Oc1ccc(C(C)(C)O)cc1-c1cn(C)c(=O)c2[nH]c(C(=O)NCCCCCCC(=O)NO)cc12 CHEMBL4794499 IC50 1.2 nM
[2H]C([2H])([2H])c1nnn(C)c1-c1cnc2c3ccc(C(C)(C)O)cc3n([C@H](c3cc(C)on3)C3CCOCC3)c2c1 CHEMBL4863199 IC50 1.2 nM
[2H]C([2H])([2H])c1nnn(C)c1-c1cnc2c3ccc(C(C)(C)O)cc3n([C@H](c3ccccc3)C3CCOCC3)c2c1 CHEMBL5185824 IC50 1.2 nM
CNC(=O)c1cc(C(=O)N[C@H]2C[C@@H]2C)cc(C(O)c2ccccc2)n1 CHEMBL4862372 pKd 1.259 nM
CCCS(=O)(=O)Nc1ccc(OC2CCCOC2)c(-c2cn(C)c(=O)c3[nH]ccc23)c1 CHEMBL3897399 Ki 1.3 nM
CCS(=O)(=O)c1ccc(OCC2CC2)c(-c2cn(C)c(=O)c3[nH]ccc23)c1 CHEMBL3949456 Ki 1.3 nM
CCS(=O)(=O)c1ccc(Oc2ccc(F)cc2F)c(-c2cn(C)c(=O)c3[nH]ccc23)c1 CHEMBL3972074 Ki 1.3 nM
CCS(=O)(=O)c1ccc(OC2CCC(C)(O)CC2)c(-c2cn(C)c(=O)c3[nH]ccc23)c1 CHEMBL3895660 Ki 1.3 nM
CCS(=O)(=O)c1ccc(O[C@H]2CC[C@@H](OC)CC2)c(-c2cn(C)c(=O)c3[nH]ccc23)c1 CHEMBL3954497 Ki 1.3 nM
Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@H](CC(=O)OC1CCC(O)CC1)c1nnc(C)n1-2 CHEMBL4098784 Kd 1.3 nM
CCS(=O)(=O)c1ccc(OCC2CC2(F)F)c(-c2cn(C)c(=O)c3[nH]c(C#CCN(C)C)cc23)c1 CHEMBL4088597 Ki 1.3 nM
CCS(=O)(=O)c1ccc2c(c1)-c1cn(C)c(=O)cc1OCCCCc1cc(F)cc(F)c1O2 CHEMBL4105618 IC50 1.3 nM
Cc1ccc2ncccc2c1-c1cc(-c2c(C)noc2C)cc2nc(C3CC3)[nH]c12 CHEMBL3926851 Kd 1.3 nM
CCNC(=O)c1cc2c(-c3cc(S(=O)(=O)CC)ccc3Oc3c(C)cc(F)cc3C)cn(C)c(=O)c2[nH]1 CHEMBL4589568 Ki 1.3 nM
Cc1cc(F)cc(C)c1Oc1ccc(C(C)(C)O)cc1-c1cn(C)c(=O)c2[nH]c(C(=O)NC34CC(C3)C4)cc12 CHEMBL4452278 Ki 1.3 nM
Cc1cc(F)cc(C)c1Oc1ccc(C(C)(C)O)cc1-c1cn(C)c(=O)c2[nH]c(C(=O)NC(C)(C)C)cc12 CHEMBL4455214 Ki 1.3 nM
CCS(=O)(=O)Nc1ccc(Oc2ccc(F)cc2F)c(-c2cn(C)c(=O)c3[nH]c(C#CCN(C)C)cc23)c1 CHEMBL4443056 Ki 1.3 nM
CCN1C(=O)C(C)(C)c2cc3nc(-c4cc(C)c(=O)n(C)c4)n([C@@H](C)c4ccccc4)c3cc21 CHEMBL4086168 IC50 1.3 nM
Cc1nnn(C)c1-c1cc2c(cc1F)c1ncc(C(C)(C)O)cc1n2[C@H](c1ccccc1)C1CCOCC1 CHEMBL5086429 IC50 1.3 nM
CCNC(=O)C1=CC2C(c3cc(S(=O)(=O)CC)ccc3Oc3c(C)cc(F)cc3C)=CN(C)C(=O)C2N1 CHEMBL5192732 Ki 1.3 nM
CCS(=O)(=O)Nc1ccc(Oc2c(C)cccc2C)c(-c2cn(C)c(=O)c3cc(-c4cc(C)c(OCCO)c(C)c4)oc23)c1 CHEMBL5204275 IC50 1.3 nM
Cn1cc(-c2cc(NS(C)(=O)=O)ccc2Oc2ccccc2)c2cc[nH]c2c1=O CHEMBL3970220 Ki 1.4 nM
Cn1cc(-c2cc(NS(=O)(=O)CC(F)(F)F)ccc2OC2CCOCC2)c2cc[nH]c2c1=O CHEMBL3906371 Ki 1.4 nM
CNS(=O)(=O)Nc1ccc(OC2CCCOC2)c(-c2cn(C)c(=O)c3[nH]ccc23)c1 CHEMBL3898595 Ki 1.4 nM
CCS(=O)(=O)c1ccc(O[C@H]2CC[C@@H](O)CC2)c(-c2cn(C)c(=O)c3[nH]ccc23)c1 CHEMBL3964534 Ki 1.4 nM
COc1cc2c(cc1-c1c(C)noc1C)[nH]c1nc(C)nc(-c3ccnc4ccccc34)c12 CHEMBL4171228 Ki 1.4 nM
COc1ccc2c([nH]c3nc(C)nc(-c4ccnc5ccccc45)c32)c1-c1c(C)noc1C CHEMBL4581411 Ki 1.4 nM
[2H]C([2H])([2H])c1nnn(C)c1-c1cnc2c3cc(F)c(C(C)(C)O)cc3n([C@H](c3cc(C)on3)C3CCOCC3)c2c1 CHEMBL4869203 IC50 1.4 nM
COC(C)(C)c1ccc2c3ncc(-c4c(C)nnn4C)cc3n([C@H](c3ccccc3)C3CCOCC3)c2c1 CHEMBL5189057 IC50 1.4 nM
Cc1cc(-c2cc3c(=O)n(C)cc(-c4cc(CS(=O)(=O)C(C)(C)C)ccc4Oc4ccc(F)cc4F)c3o2)cc(C)c1OCCO CHEMBL5183265 IC50 1.4 nM
CCc1cccc(C)c1Oc1ccc(NS(=O)(=O)CC)cc1-c1cn(C)c(=O)c2cc(-c3cc(C)c(OCCO)c(C)c3)oc12 CHEMBL5169842 IC50 1.4 nM
Cc1cc(-c2cc3c(=O)n(C)cc(-c4cc(C(C)(C)O)ccc4Oc4c(C)cc(F)cc4C)c3o2)cc(C)c1OCCCO CHEMBL5179959 IC50 1.4 nM
CN1CCN(CCNC(=O)c2cccc(CN3c4ccccc4C=C4c5c(cccc53)C(=O)N4C)c2)CC1 CHEMBL5420470 IC50 1.4 nM
Cc1cc(F)cc(C)c1Oc1ccc(C(C)(C)O)cc1-c1cn(C)c(=O)c2cc(-c3cnc(C4CCCCC4)[nH]3)oc12 CHEMBL5204783 IC50 1.44 nM
CNS(=O)(=O)c1ccc(OCC2CC2)c(-c2cn(C)c(=O)c3[nH]ccc23)c1 CHEMBL3907322 Ki 1.5 nM
CC(C)S(=O)(=O)c1ccc(NCC2CC2)c(-c2cn(C)c(=O)c3[nH]ccc23)c1 CHEMBL3943834 Ki 1.5 nM
Cn1cc(-c2cc(NS(C)(=O)=O)ccc2Oc2c(F)cc(F)cc2F)c2cc[nH]c2c1=O CHEMBL3940880 Ki 1.5 nM
Cn1cc(-c2cc(S(C)(=O)=O)ccc2OCC2C[C@@H]3CC[C@H]2C3)c2cc[nH]c2c1=O CHEMBL4109883 Ki 1.5 nM
CC1CCC(Oc2ccc(S(C)(=O)=O)cc2-c2cn(C)c(=O)c3[nH]ccc23)CC1 CHEMBL3906773 Ki 1.5 nM
CCS(=O)(=O)Nc1ccc2c(c1)-c1cn(C)c(=O)cc1OCCCCc1cc(Cl)ccc1O2 CHEMBL4073279 Ki 1.5 nM
CCS(=O)(=O)Nc1ccc2c(c1)-c1cn(C)c(=O)cc1OCCCCc1cc(F)cc(F)c1O2 CHEMBL4099010 Ki 1.5 nM
CCNC(=O)c1cc2c(-c3cc(C4(O)CCC4)ccc3Oc3c(C)cc(F)cc3C)cn(C)c(=O)c2[nH]1 CHEMBL4464739 Ki 1.5 nM
Cn1cc(-c2cc(C(C)(C)O)ccc2Oc2ccc(F)cc2F)c2cc(C(=O)NCc3ccc(C(=O)Nc4ccccc4N)cc3)[nH]c2c1=O CHEMBL4776819 IC50 1.5 nM
Cc1cc(F)cc(C)c1Oc1ccc(C(C)(C)O)cc1-c1cn(C)c(=O)c2[nH]c(C(=O)NCc3ccc(C(=O)NO)cc3)cc12 CHEMBL4753842 IC50 1.5 nM
Cc1noc(C)c1-c1cc(C(N)=O)c2c3ccc(C(C)(C)O)cc3n(C(c3ccccc3)c3ccccc3)c2c1 CHEMBL5093440 IC50 1.5 nM
Cc1cnc(Nc2ccc(C(=O)NC3CCN(C(=O)CCOCCOCCOCCOCCOCCC(=O)N4CCC(NC(=O)c5ccc(Nc6ncc(C)c(Nc7ccc(Cl)c(NS(=O)(=O)C(C)(C)C)c7)n6)cc5F)CC4)CC3)c(F)c2)nc1Nc1ccc(Cl)c(NS(=O)(=O)C(C)(C)C)c1 CHEMBL5206426 Kd 1.5 nM
CCS(=O)(=O)Nc1ccc(Oc2ccc(F)cc2F)c(-c2cn(C)c(=O)c3cc(-c4ccccc4)oc23)c1 CHEMBL5200884 IC50 1.5 nM
COc1nnc2ccc(N3CCC(c4ccc(OCCN5[C@H](C)CN(C(C)=O)C[C@@H]5C)cc4)CC3)nn12 CHEMBL4591500 pKi 1.585 nM
Cn1cc(-c2cc(NS(C)(=O)=O)ccc2Oc2ccccc2)c2cc(CO)[nH]c2c1=O CHEMBL3909486 Ki 1.6 nM
COc1cc2c(cc1-c1c(C)noc1C)[nH]c1nc(C)nc(-c3cc(C)nc4ccccc34)c12 CHEMBL4203276 Ki 1.6 nM
CCS(=O)(=O)Cc1cnc(Oc2ccc(F)cc2F)c(-c2cc(C)c3c(=O)[nH]ccn23)c1 CHEMBL4440098 Kd 1.6 nM
Cc1cc([C@H](C2CCOCC2)n2c3cc(C(C)(C)O)ccc3c3ncc(-c4c(C)nnn4C)cc32)no1 CHEMBL4857742 IC50 1.6 nM
COc1nnc2ccc(N3CCC(c4ccc(OCCN5CCN(C)C(=O)[C@H]5C)cc4)CC3)nn12 CHEMBL4078100 IC50 1.6 nM
CN1CCC(NC(=O)c2cccc(CN3c4ccccc4C=C4c5c(cccc53)C(=O)N4C)c2)CC1 CHEMBL5393744 IC50 1.6 nM
Cc1cc2n3c(c[nH]c(=O)c13)CN(C(=O)c1ccc3ccccc3c1)c1ccc(CS(C)(=O)=O)cc1-2 CHEMBL5437856 IC50 1.6 nM
Cn1cc(-c2cc(NS(C)(=O)=O)cc(Cl)c2Oc2ccccc2)c2cc[nH]c2c1=O CHEMBL3899772 Ki 1.7 nM
Cn1cc(-c2cc(S(C)(=O)=O)ccc2Oc2ccccc2)c2cc[nH]c2c1=O CHEMBL3973984 Ki 1.7 nM
Cn1cc(-c2cc(S(C)(=O)=O)ccc2OCC2CCCC2)c2cc[nH]c2c1=O CHEMBL3955835 Ki 1.7 nM
CCS(=O)(=O)Nc1cc(-c2cn(C)c(=O)c3[nH]ccc23)c(Oc2ccc(F)cc2F)cc1CN1CCOCC1 CHEMBL4067346 Ki 1.7 nM
COc1cc2c(cc1-c1c(C)noc1C)[nH]c1nc(C)nc(Nc3n[nH]c4ccccc34)c12 CHEMBL4168913 Ki 1.7 nM
COc1nnc2ccc(N3CCC(c4ccc(OCCN5CCN(C)C(=O)C5C)cc4)CC3)nn12 CHEMBL4593553 IC50 1.7 nM
CCNC(=O)c1cc2c(-c3cc(CO)ccc3Oc3c(C)cccc3C)cn(C)c(=O)c2[nH]1 CHEMBL4554545 Ki 1.7 nM
Cc1noc(C)c1-c1cnc2c(-c3ccc(C(=O)O)cc3)cn([C@@H](C)c3ccccn3)c2c1 CHEMBL4521078 Kd 1.7 nM
[2H]C([2H])([2H])c1nnn(C)c1-c1cnc2c3ccc(S(C)(=O)=O)cc3n([C@H](c3ccccc3)C3CCOCC3)c2c1 CHEMBL5179686 IC50 1.7 nM
Cc1cnc(Nc2ccc(C(=O)NC3CCNCC3)c(F)c2)nc1Nc1cc(NS(=O)(=O)C(C)(C)C)cc(C(=O)NCCOCCOCCOCCC(=O)N2CCC(NC(=O)c3ccc(Nc4ncc(C)c(Nc5ccc(Cl)c(NS(=O)(=O)C(C)(C)C)c5)n4)cc3F)CC2)c1 CHEMBL5188470 Kd 1.7 nM
Cn1cc(-c2cc(NS(C)(=O)=O)ccc2Oc2cccnc2)c2cc[nH]c2c1=O CHEMBL3942897 Ki 1.8 nM
Cn1cc(-c2cc(NS(C)(=O)=O)ccc2OC2CCOC2)c2cc[nH]c2c1=O CHEMBL3902857 Ki 1.8 nM
Cn1cc(-c2cc(S(C)(=O)=O)ccc2OC2CCCC2)c2cc[nH]c2c1=O CHEMBL3950512 Ki 1.8 nM
CN1CCN(Cc2cc3c(-c4cc(S(C)(=O)=O)ccc4Oc4ccc(F)cc4F)cn(C)c(=O)c3[nH]2)CC1 CHEMBL3894401 Ki 1.8 nM
Cn1nc(-c2cc(NS(C)(=O)=O)ccc2Oc2ccccc2)c2cc(C(N)=O)[nH]c2c1=O CHEMBL3921789 Ki 1.8 nM
CN1CCN(CCNC(=O)c2cc3c(-c4cc(NS(C)(=O)=O)ccc4Oc4ccccc4)nn(C)c(=O)c3[nH]2)CC1 CHEMBL3945583 Ki 1.8 nM
Cn1cc(-c2cc(S(N)(=O)=O)cnc2OCC2CC2)c2cc[nH]c2c1=O CHEMBL3891129 Ki 1.8 nM
CCNC(=O)c1ccc(Oc2c(C)cccc2C)c(-c2cn(C)c(=O)c3[nH]c(C(=O)NCC)cc23)c1 CHEMBL4449740 Ki 1.8 nM
CCNC(=O)c1cc2c(-c3cc(S(=O)(=O)CC)ccc3-n3ccc4ccccc43)cn(C)c(=O)c2[nH]1 CHEMBL4590365 Ki 1.8 nM
Cn1cc2c3c(c[nH]c(=O)c31)CN(c1ccc(F)cc1F)c1ccc(CS(C)(=O)=O)cc1-2 CHEMBL4444009 IC50 1.8 nM
Cn1cc(-c2cc(NS(=O)(=O)CC(F)(F)F)ccc2OC2CCC(F)(F)CC2)c2cc[nH]c2c1=O CHEMBL3920004 Ki 1.9 nM
CCS(=O)(=O)c1ccc(OC2CCC(=O)CC2)c(-c2cn(C)c(=O)c3[nH]ccc23)c1 CHEMBL3955367 Ki 1.9 nM
CCS(=O)(=O)Nc1ccc(Oc2c(F)cc(F)cc2F)c(-c2cn(C)c(=O)c3[nH]ccc23)c1 CHEMBL3933555 Ki 1.9 nM
Cn1cc(-c2cc(S(N)(=O)=O)ccc2Oc2ccc(F)cc2F)c2cc[nH]c2c1=O CHEMBL3927275 Ki 1.9 nM
CC(C)S(=O)(=O)c1ccc(Oc2ccc(F)cc2F)c(-c2cn(C)c(=O)c3[nH]ccc23)c1 CHEMBL3940538 Ki 1.9 nM
Cn1cc(-c2cc(S(=O)(=O)C3CC3)ccc2Oc2ccc(F)cc2F)c2cc[nH]c2c1=O CHEMBL3949335 Ki 1.9 nM
CCS(=O)(=O)c1ccc2c(c1)-c1cn(C)c(=O)cc1OCCCCc1ccccc1O2 CHEMBL4090068 Ki 1.9 nM
Cc1noc(C)c1-c1cc(C(N)=O)c2c3ccc(C(C)(C)O)cc3n([C@H](c3ccc(F)cc3)C3CCOCC3)c2c1 CHEMBL5082474 IC50 1.9 nM
Cc1noc(C)c1-c1cnc2c3ccc(C(C)(C)O)cc3n([C@H](c3ccccc3)C3CCOCC3)c2c1 CHEMBL5087175 IC50 1.9 nM
Cc1cc(-c2cc3c(=O)n(C)cc(-c4cc(NC(=O)C(C)C)ccc4Oc4ccc(F)cc4F)c3o2)cc(C)c1OCCO CHEMBL5181765 IC50 1.9 nM
CNC(=O)c1cc(C(=O)N[C@H]2[C@@H]3COC[C@@H]32)cc2c1O[C@H](CF)[C@H]2c1ccccc1 CHEMBL4637208 pKd 1.995 nM
CCS(=O)(=O)c1ccc2c(c1)-c1cn(C)c(=O)cc1OCCCCc1cc(F)ccc1O2 CHEMBL3786559 IC50 2.0 nM
CCS(=O)(=O)c1ccc(OCC2CC2(F)F)c(-c2cn(C)c(=O)c3[nH]ccc23)c1 CHEMBL3891849 Ki 2.0 nM
Cc1noc(C)c1-c1cc(C(O)(c2cccnn2)C2CCCO2)c2nc(C3CC3)[nH]c2c1 CHEMBL3921106 IC50 2.0 nM
CCNC(=O)CC1N=C(C2CCCCC2)c2cc(OC)ccc2-c2cn(C)c(=O)cc21 CHEMBL4095826 IC50 2.0 nM
Cc1nnn2c1-c1ccc(-c3nn[nH]n3)cc1N(c1ccc(Cl)cc1)CC2 CHEMBL4165389 IC50 2.0 nM
Cc1nnn2c1-c1ccc(C(N)=O)cc1N(c1ccc(Cl)cc1)CC2 CHEMBL4161767 IC50 2.0 nM
COc1cc2c(cc1-c1c(C)noc1C)[nH]c1nc(C)nc(Nc3cc(C4CCC4)nn3C)c12 CHEMBL4159422 Ki 2.0 nM
CCOc1ccc(S(=O)(=O)CC)cc1-c1cn(C)c(=O)c2ccc(-c3cnn(C)c3)cc12 CHEMBL3787482 IC50 2.0 nM
CCCOc1ccc(S(=O)(=O)CC)cc1-c1cn(C)c(=O)c2ccc(-c3cnn(C)c3)cc12 CHEMBL4227923 IC50 2.0 nM
Cc1nnn2c1-c1ccc(-c3cc[nH]n3)cc1C(c1ccc(Cl)cc1)=NC2 CHEMBL4293904 IC50 2.0 nM
Cc1cc(F)cc(C)c1Oc1ccc(C(C)(C)O)cc1-c1cn(C)c(=O)c2[nH]c(C(=O)NC3(C)CC3(F)F)cc12 CHEMBL4521111 Ki 2.0 nM
[2H]C([2H])([2H])c1nnn(C)c1-c1cnc2c3ccc(C(C)(C)O)c(F)c3n([C@H](c3cc(C)on3)C3CCOCC3)c2c1 CHEMBL4875203 IC50 2.0 nM
CC(=O)N1c2ccc(-c3cc[nH]n3)cc2[C@H](Nc2ccc(C#N)cc2)C[C@@H]1C CHEMBL5205867 Kd 2.0 nM
CCS(=O)(=O)Nc1ccc(Oc2c(OC)cccc2OC)c(-c2cn(C)c(=O)c3cc(-c4cc(C)c(OCCO)c(C)c4)oc23)c1 CHEMBL5207143 IC50 2.0 nM
Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCOCCOCCNC(=O)C[C@@H]2N=C(c3ccc(Cl)cc3)c3c(sc(C)c3C)-n3c(C)nnc32)C(C)(C)C)cc1 CHEMBL4226570 DC50 2.0 nM
Cn1cc(-c2cc(NS(C)(=O)=O)ccc2Oc2ccc(F)cc2)c2cc[nH]c2c1=O CHEMBL3912330 Ki 2.1 nM
Cn1cc(-c2cc(NS(C)(=O)=O)ccc2OC2CCCC2)c2cc[nH]c2c1=O CHEMBL3920634 Ki 2.1 nM
Cn1cc(-c2cc(NS(C)(=O)=O)cc(F)c2Oc2ccccc2)c2cc[nH]c2c1=O CHEMBL3921276 Ki 2.1 nM
Cn1cc(-c2cc(NS(C)(=O)=O)ccc2Oc2ccc(F)cc2Cl)c2cc[nH]c2c1=O CHEMBL3901761 Ki 2.1 nM
COc1ccc(S(=O)(=O)Nc2cccc(Oc3ccc(S(C)(=O)=O)cc3-c3cn(C)c(=O)c4[nH]ccc34)c2)cc1 CHEMBL4075943 Ki 2.1 nM
CCNC(=O)c1cc2c(-c3cc(S(=O)(=O)CC)ccc3Oc3c(C)cccc3C(F)F)cn(C)c(=O)c2[nH]1 CHEMBL4586647 Ki 2.1 nM
CCNC(=O)c1cc2c(-c3cc(S(=O)(=O)CC)ccc3Oc3ccccc3C(C)(C)C)cn(C)c(=O)c2[nH]1 CHEMBL4555653 Ki 2.1 nM
Cc1nnc2n1-c1sc(C#Cc3cccnc3)c(Cc3ccccc3)c1COC2 CHEMBL4544682 Ki 2.1 nM
CC(C)Oc1ccc(C(C)(C)O)cc1-c1cn(C)c(=O)c2[nH]c(C(=O)NCc3ccc(C(=O)Nc4ccccc4N)cc3)cc12 CHEMBL4747126 IC50 2.1 nM
Cn1cc(-c2cc(C(C)(C)O)ccc2OC2CC2)c2cc(C(=O)NCc3ccc(C(=O)Nc4ccccc4N)cc3)[nH]c2c1=O CHEMBL4758435 IC50 2.1 nM
CCNC(=O)C1=CC2C(c3cc(C(C)(C)O)ccc3Oc3c(C)cc(F)cc3C)=CN(C)C(=O)C2N1 CHEMBL5265827 Kd 2.1 nM
Cn1cc(-c2cc(NS(C)(=O)=O)ccc2Oc2ccc(F)cc2F)c2cc[nH]c2c1=O CHEMBL3974260 Ki 2.2 nM
Cn1cc(-c2cc(S(C)(=O)=O)ccc2Oc2ccc(CC(N)=O)cc2)c2cc[nH]c2c1=O CHEMBL3917690 Ki 2.2 nM
COc1cc2c(cc1-c1c(C)noc1C)[nH]c1ncnc(-c3c[nH]c4ccc(F)cc34)c12 CHEMBL4211497 IC50 2.2 nM
[2H]C([2H])([2H])c1nnn(C)c1-c1cnc2c3cc(Cl)c(C(C)(C)O)cc3n([C@H](c3ccccc3)C3CCOCC3)c2c1 CHEMBL5209210 IC50 2.2 nM
CCOc1cc(=O)n(C)cc1-c1cc(N(CC2CC2)S(=O)(=O)CC)ccc1Oc1ccc(F)cc1F CHEMBL3906306 Ki 2.28 nM
Cn1cc(-c2cc(NS(C)(=O)=O)ccc2Oc2ccc(F)c(F)c2)c2cc[nH]c2c1=O CHEMBL3963683 Ki 2.3 nM
CNS(=O)(=O)c1cnc(NC2CCCCC2)c(-c2cn(C)c(=O)c3[nH]ccc23)c1 CHEMBL3972632 Ki 2.3 nM
Cn1cc2c3c(c[nH]c(=O)c31)-c1cc(CS(C)(=O)=O)ccc1N(c1ccccn1)C2 CHEMBL4213481 IC50 2.3 nM
Cc1nnc2n1-c1sc(C#Cc3cnn(C)c3)c(Cc3ccccc3)c1COC2 CHEMBL4555209 Ki 2.3 nM
Cc1cc([C@H](C2CCOCC2)n2c3cc(C(C)(C)O)ccc3c3ncc(-c4c(C)nnn4C)cc32)n(C)n1 CHEMBL4871769 IC50 2.3 nM
CCS(=O)(=O)Nc1ccc(Oc2ccc(Cl)cc2)c(-c2cn(C)c(=O)c3ccccc23)c1 CHEMBL5184876 Kd 2.3 nM
CC1CC1COc1ccc(S(C)(=O)=O)cc1-c1cn(C)c(=O)c2[nH]ccc12 CHEMBL3960784 Ki 2.4 nM
Cn1cc(-c2cc(S(=O)(=O)N3CCCC3)ccc2OCC2CC2(F)F)c2cc[nH]c2c1=O CHEMBL3953353 Ki 2.4 nM
Cn1cc(-c2cc(C(=O)N3CCOCC3)ccc2Oc2ccc(F)cc2F)c2cc[nH]c2c1=O CHEMBL3911704 Ki 2.4 nM
Cn1cc(-c2cc(S(N)(=O)=O)cnc2OC2CCOC2)c2cc[nH]c2c1=O CHEMBL3901199 Ki 2.4 nM
CNS(=O)(=O)c1ccc(NCC2CC2)c(-c2cn(C)c(=O)c3[nH]ccc23)c1 CHEMBL3986256 Ki 2.4 nM
COc1cc2c(cc1-c1c(C)noc1C)[nH]c1nc(C)nc(Nc3cc(C(C)(C)C(F)(F)F)nn3C)c12 CHEMBL4170044 Ki 2.4 nM
CCCS(=O)(=O)Nc1ccc(OC2CCOC2)c(-c2cn(C)c(=O)c3[nH]ccc23)c1 CHEMBL3924952 Ki 2.5 nM
CN(C)S(=O)(=O)c1cnc(NCC2CC2)c(-c2cn(C)c(=O)c3[nH]ccc23)c1 CHEMBL3968444 Ki 2.5 nM
Cc1cc2n3c(c[nH]c(=O)c13)CN(C(=O)c1cccc3ccccc13)c1ccc(CS(C)(=O)=O)cc1-2 CHEMBL5440806 IC50 2.5 nM
C[C@H]1C(=O)N(C)C=Cc2cc(OCCCOc3ccc4c(c3)C=CN(C)C(=O)[C@@H]4C)ccc21 CHEMBL5426762 pEC50 2.512 nM
CN(c1ccc(Oc2ccccc2)c(-c2cn(C)c(=O)c3[nH]ccc23)c1)S(C)(=O)=O CHEMBL3941303 Ki 2.6 nM
Cn1cc(-c2cc(NS(C)(=O)=O)ccc2Oc2ccc(C#N)cc2)c2cc[nH]c2c1=O CHEMBL3926269 Ki 2.6 nM
CCOc1cc(=O)n(C)cc1-c1cc(NS(=O)(=O)CC)ccc1Oc1ccc(Cl)cc1 CHEMBL4091597 Ki 2.6 nM
COc1cc2c(cc1-c1c(C)noc1C)[nH]c1nc(C)nc(Nc3cc(C)nn3C3CCC3)c12 CHEMBL4163185 Ki 2.6 nM
CCS(=O)(=O)Nc1ccc(OCC2CC2)c(-c2cn(C)c(=O)c3[nH]ccc23)c1 CHEMBL3951504 Ki 2.7 nM
CNS(=O)(=O)Nc1ccc(Oc2c(F)cc(F)cc2F)c(-c2cn(C)c(=O)c3[nH]ccc23)c1 CHEMBL3897979 Ki 2.7 nM
Cc1cccc(C(O)(c2cc(-c3c(C)noc3C)cc3[nH]c(C4CC4)nc23)C2CCCO2)n1 CHEMBL3895799 IC50 2.7 nM
Cc1noc(C)c1-c1cc(C(O)(c2cnccn2)c2c(F)cccc2F)c2[nH]c(=O)[nH]c2c1 CHEMBL4062849 K 2.7 nM
COc1cc2c(cc1-c1c(C)noc1C)[nH]c1ncnc(-c3c(C4CC4)n[nH]c3C)c12 CHEMBL4215403 Ki 2.7 nM
CCS(=O)(=O)Nc1ccc2c(c1)-c1c[nH]c(=O)c3c1c(cn3C)CN2c1ccccn1 CHEMBL4214501 Ki 2.7 nM
Cn1cc2c3c(c[nH]c(=O)c31)-c1cc(CS(C)(=O)=O)ccc1N(c1ccc(F)cc1F)C2 CHEMBL4204316 Ki 2.7 nM
Cc1nnc2n1-c1sc(C#Cc3ccccn3)c(Cc3ccccc3)c1COC2 CHEMBL4463778 Ki 2.7 nM
CCS(=O)(=O)Nc1ccc2c(c1)-c1cn(C)c(=O)cc1OCCCCCc1cc(Cl)ccc1O2 CHEMBL4094644 Ki 2.8 nM
COc1cc2c(cc1-c1c(C)noc1C)[nH]c1ncnc(-c3c(C)oc4ccccc34)c12 CHEMBL4207609 Ki 2.8 nM
COc1cc2c(cc1-c1c(C)noc1C)[nH]c1ncnc(-n3cnc4ccccc43)c12 CHEMBL4212515 Ki 2.8 nM
CCNC(=O)c1cc2c(-c3cc(C(=O)O)ccc3Oc3c(C)cccc3C)cn(C)c(=O)c2[nH]1 CHEMBL4579396 Ki 2.8 nM
[2H]C([2H])([2H])c1nnn(C)c1-c1cnc2c3c(F)cc(C(C)(C)O)cc3n([C@H](c3cc(C)on3)C3CCOCC3)c2c1 CHEMBL4855116 IC50 2.8 nM
Cc1cnc(Nc2ccc(C(=O)NC3CCN(C(=O)CCOCCOCCOCCOCCC(=O)N4CCC(NC(=O)c5ccc(Nc6ncc(C)c(Nc7ccc(Cl)c(NS(=O)(=O)C(C)(C)C)c7)n6)cc5F)CC4)CC3)c(F)c2)nc1Nc1ccc(Cl)c(NS(=O)(=O)C(C)(C)C)c1 CHEMBL5178175 Kd 2.8 nM
CCS(=O)(=O)C(C)(C)c1ccc(Oc2ccc(F)cc2F)c(-c2cn(C)c(=O)c3[nH]ccc23)c1 CHEMBL3941742 Ki 2.9 nM
Cn1cc(-c2cc(S(C)(=O)=O)ccc2OCCC2CC2)c2cc[nH]c2c1=O CHEMBL3923757 Ki 2.9 nM
CCNC(=O)c1cc2c(-c3cc(NC(=O)OC)ccc3Oc3c(C)cc(F)cc3C)cn(C)c(=O)c2[nH]1 CHEMBL4533567 Ki 2.9 nM
CCS(=O)(=O)c1ccc(OC2CCCCC2)c(-c2cn(C)c(=O)c3[nH]c(-c4cnn(C5CCNCC5)c4)cc23)c1 CHEMBL3787680 IC50 3.0 nM
Cn1cc(-c2cc(NS(C)(=O)=O)ccc2Oc2ccccc2C#N)c2cc[nH]c2c1=O CHEMBL3982262 Ki 3.0 nM
Cn1cc(-c2cc(S(C)(=O)=O)ccc2OCC2CCC2)c2cc[nH]c2c1=O CHEMBL3977412 Ki 3.0 nM
Cn1cc(-c2cc(NS(C)(=O)=O)ccc2OC2C3CC4CC(C3)CC2C4)c2cc[nH]c2c1=O CHEMBL3982526 Ki 3.0 nM
CCS(=O)(=O)Nc1ccc(Oc2ccc(F)cc2F)c(-c2cn(C)c(=O)c3[nH]ncc23)c1 CHEMBL3939106 Ki 3.0 nM
Cn1cc(-c2cc(S(C)(=O)=O)ccc2Oc2ccccc2F)c2cc[nH]c2c1=O CHEMBL3951463 Ki 3.0 nM
Cn1cc(-c2cc(S(C)(=O)=O)ccc2Oc2ccc(F)cc2F)c2cc(C(=O)Nc3nccs3)[nH]c2c1=O CHEMBL3955072 Ki 3.0 nM
Cc1nnc2c(NC3CCN(C)CC3)cc(N(C)Cc3ccccc3)nn12 CHEMBL3983439 IC50 3.0 nM
Cc1nnc2c(NC3CCN(C)CC3)cc(-c3[nH]c4ccccc4c3Cc3ccccc3)nn12 CHEMBL3977798 IC50 3.0 nM
Cc1nnc2c(NC3CCN(C)CC3)cc(-c3cn(C)nc3Cc3ccccc3)nn12 CHEMBL3943040 IC50 3.0 nM
CCN1CCC(Nc2cc(N(C)Cc3ccccc3)nn3c(C)nnc23)CC1 CHEMBL3960956 IC50 3.0 nM
COCCN1CCC(Nc2cc(N(C)Cc3ccccc3)nn3c(C)nnc23)CC1 CHEMBL3984289 IC50 3.0 nM
Cc1noc(C)c1-c1cc(-c2c(C3CC3)n[nH]c2C2CC2)c2[nH]c(=O)[nH]c2c1 CHEMBL4096882 K 3.0 nM
CCOC(=O)CC1N=C(c2ccc(Cl)cc2)c2cc(OC)ccc2-c2cn(C)c(=O)cc21 CHEMBL4088097 IC50 3.0 nM
CC(=O)N1c2ccc(-c3ccc(C(=O)NCCOCCOCC(=O)N[C@H](C(=O)N4C[C@H](O)C[C@H]4C(=O)NCc4ccc(-c5scnc5C)cc4)C(C)(C)C)cc3)cc2[C@H](Nc2ccc(Cl)cc2)C[C@@H]1C CHEMBL4227834 Kd 3.0 nM
Cc1nnc2n1-c1ccc(-c3ccc(N)nc3)cc1N(c1ccc(Cl)cc1)C[C@H]2C CHEMBL4780530 IC50 3.0 nM
Cn1cc(-c2cc(C(C)(C)O)ccc2Oc2ccccc2)c2cc(C(=O)NCc3ccc(C(=O)Nc4ccccc4N)cc3)[nH]c2c1=O CHEMBL4761044 IC50 3.0 nM
Cc1noc(C)c1-c1ccc2c(c1)C(c1ccccc1)N(CCCCN1CCN(c3ccc4nnc(Cl)n4n3)CC1)C(=O)N2C CHEMBL4850099 IC50 3.0 nM
Cc1noc2c1-c1ccccc1C(c1ccc(Cl)cc1)=N[C@H]2CC(N)=O CHEMBL4303404 IC50 3.0 nM
Cc1nnn(C)c1-c1cnc2c3ccc(C(C)(O)C(F)(F)F)c(F)c3n([C@H](c3ccccc3)C3CCOCC3)c2c1 CHEMBL5201345 IC50 3.0 nM
Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)NCCO)c1nnc(C)n1-2 CHEMBL5400310 IC50 3.0 nM
CN(C)S(=O)(=O)c1cnc(OC2CCOC2)c(-c2cn(C)c(=O)c3[nH]ccc23)c1 CHEMBL3962043 Ki 3.1 nM
CCS(=O)(=O)Nc1ccc(Oc2ccc(F)cc2F)c(-c2cn(C)c(=O)c3[nH]cc(C=O)c23)c1 CHEMBL3917193 Ki 3.1 nM
CC1=C(C)C2C(c3ccc(Cl)cc3)=N[C@@H](CC(=O)NCCOCCOCCOCCOCCOCCOCCOCCNC(=O)C[C@@H]3N=C(c4ccc(Cl)cc4)c4c(sc(C)c4C)-n4c(C)nnc43)c3nnc(C)n3C2S1 CHEMBL4077359 IC50 3.1 nM
COc1cc2c(cc1-c1c(C)noc1C)[nH]c1nc(C)nc(Nc3cc(C(F)(F)F)nn3C)c12 CHEMBL4166235 Ki 3.1 nM
COc1cc2c(cc1-c1c(C)noc1C)[nH]c1nc(C)nc(-c3cccc4ncccc34)c12 CHEMBL4208561 Ki 3.1 nM
Cc1noc(C)c1-c1ccc2c(c1)C(c1ccccc1)N(CCCCCCN1CCN(c3ccc4nnc(Cl)n4n3)CC1)C(=O)N2C CHEMBL4873148 IC50 3.1 nM
Cc1cnc(Nc2ccc(C(=O)NC3CCN(C(=O)COCCOCC(=O)N4CCC(NC(=O)c5ccc(Nc6ncc(C)c(Nc7ccc(Cl)c(NS(=O)(=O)C(C)(C)C)c7)n6)cc5F)CC4)CC3)c(F)c2)nc1Nc1ccc(Cl)c(NS(=O)(=O)C(C)(C)C)c1 CHEMBL5201173 Kd 3.1 nM
CC1=C(C)C2C(c3ccc(Cl)cc3)=N[C@@H](CC(=O)NCCOCCOCCOCCOCCOCCOCCOCCNC(=O)C[C@@H]3N=C(c4ccc(Cl)cc4)C4C(C)=C(C)SC4n4c(C)nnc43)c3nnc(C)n3C2S1 CHEMBL5274937 IC50 3.1 nM
COc1nnc2ccc(N3CCC(c4ccc(CCN5CCN(C)C(=O)[C@H]5C)cc4)CC3)nn12 CHEMBL4447492 pKi 3.162 nM
COc1nnc2ccc(N3CCC(c4ccc(OCCCN5CCN(C)C(=O)[C@H]5C)cc4)CC3)nn12 CHEMBL4466676 pIC50 3.162 nM
Cn1cc(-c2cc(S(C)(=O)=O)ccc2OC2CCC2)c2cc[nH]c2c1=O CHEMBL3893858 Ki 3.2 nM
COc1ccccc1Oc1ccc(S(C)(=O)=O)cc1-c1cn(C)c(=O)c2[nH]ccc12 CHEMBL3957020 Ki 3.2 nM
CCNC(=O)c1cc2c(-c3cc(S(=O)(=O)CC)ccc3Oc3c(C)cccc3C#N)cn(C)c(=O)c2[nH]1 CHEMBL4440089 Ki 3.2 nM
Cc1cc(-c2cc3c(=O)n(C)cc(-c4cc(NC(=O)C5CC5)ccc4Oc4ccc(F)cc4F)c3o2)cc(C)c1OCCO CHEMBL5204795 IC50 3.2 nM
Cn1cc(-c2cc(S(C)(=O)=O)ccc2OCC2CCOC2)c2cc[nH]c2c1=O CHEMBL3967866 Ki 3.3 nM
Cc1ccc(F)c(Oc2ccc(S(C)(=O)=O)cc2-c2cn(C)c(=O)c3[nH]ccc23)c1 CHEMBL3914223 Ki 3.3 nM
COC(=O)c1cc2c(cc1CS(C)(=O)=O)-c1cn(C)c(=O)c3[nH]cc(c13)CN2c1ncc(C#CCN)cc1F CHEMBL4787589 IC50 3.3 nM
CCCS(=O)(=O)Nc1ccc(OC2CCC(F)(F)CC2)c(-c2cn(C)c(=O)c3[nH]ccc23)c1 CHEMBL3918915 Ki 3.4 nM
CCNC(=O)c1ccc(Oc2ccccc2)c(-c2cn(C)c(=O)c3[nH]ccc23)c1 CHEMBL3919590 Ki 3.4 nM
CCS(=O)(=O)Nc1ccc(Oc2ccc(Cl)cc2)c(-c2cn(C)c(=O)c3[nH]ccc23)c1 CHEMBL4098055 Ki 3.4 nM
CCS(=O)(=O)Nc1cnc2c(c1)-c1cn(C)c(=O)cc1OCCCCc1cc(Cl)ccc1O2 CHEMBL4075776 Ki 3.4 nM
CCn1nc(C)cc1Nc1nc(C)nc2[nH]c3cc(-c4c(C)noc4C)c(OC)cc3c12 CHEMBL4174543 Ki 3.4 nM
CCCS(=O)(=O)Nc1ccc(OC2CCOCC2)c(-c2cn(C)c(=O)c3[nH]ccc23)c1 CHEMBL3934348 Ki 3.5 nM
Cn1cc(-c2cc(S(=O)(=O)N3CCCC3)ccc2OCC2CC2)c2cc[nH]c2c1=O CHEMBL3950014 Ki 3.5 nM
Cc1nnc2n1-c1ccc(-c3cnn(C)c3)cc1[C@H](Nc1ccc(Cl)cc1)CC2 CHEMBL4528047 Kd 3.5 nM
Cc1cc(-c2cc(CS(C)(=O)=O)cnc2Oc2ccc(F)cc2F)n2cc[nH]c(=O)c12 CHEMBL4543167 IC50 3.5 nM
Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)Nc1ccc(O)cc1)c1nnc(C)n1-2 CHEMBL3581647 Kd 3.5 nM
Cn1cc(-c2cc(S(C)(=O)=O)ccc2Oc2cccc(N)c2)c2cc[nH]c2c1=O CHEMBL3889688 Ki 3.6 nM
Cn1cc(-c2cc(S(N)(=O)=O)cnc2NCC2CC2)c2cc[nH]c2c1=O CHEMBL3964678 Ki 3.6 nM
CCS(=O)(=O)c1ccc(Oc2cccc(CO)c2)c(-c2cn(C)c(=O)c3[nH]ccc23)c1 CHEMBL3975757 Ki 3.6 nM
Cc1noc(C)c1-c1cc(C(O)(c2cccnn2)C2CCC(C)(C)O2)c2nc(C3CC3)[nH]c2c1 CHEMBL3982102 IC50 3.6 nM
CN1C(=O)c2cccc3c2C1=Cc1ccccc1N3Cc1cccc(C(N)=O)c1 CHEMBL5409463 IC50 3.6 nM
Cn1cc(-c2cc(S(C)(=O)=O)ccc2OCC2(C)CC2)c2cc[nH]c2c1=O CHEMBL3901319 Ki 3.7 nM
Cn1cc2c3c(c[nH]c3c1=O)CN(C1CCC(F)(F)CC1)c1ccc(CS(C)(=O)=O)cc1-2 CHEMBL4208136 IC50 3.7 nM
Cc1nnc2n1-c1sc(C#CC3CC3)c(Cc3ccccc3)c1COC2 CHEMBL4452894 Ki 3.7 nM
CCS(=O)(=O)Nc1ccc(Oc2ccc(F)cc2F)c(-c2cn(C)c(=O)c3cc(-c4cc(C)cc(C)c4)oc23)c1 CHEMBL5176332 IC50 3.7 nM
Cn1cc2c(cc1=O)OCCCCc1cc(Cl)ccc1Oc1ccc(CS(C)(=O)=O)cc1-2 CHEMBL4089651 Ki 3.8 nM
COc1cc2c(cc1-c1c(C)noc1C)[nH]c1nc(C)nc(-c3cncc4ccccc34)c12 CHEMBL4210754 Ki 3.8 nM
Cn1cc(-c2ccccc2Oc2ccccc2)c2cc(C(=O)NCCCCCC(=O)NO)[nH]c2c1=O CHEMBL4777392 IC50 3.8 nM
Cn1cc(-c2cc(C(C)(C)O)ccc2Oc2ccccc2)c2cc(C(=O)NCc3ccc(C(=O)NCCCCNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)cc3)[nH]c2c1=O CHEMBL5172487 IC50 3.82 nM
CCS(=O)(=O)c1ccc(OC2CCN(C(C)=O)CC2)c(-c2cn(C)c(=O)c3[nH]ccc23)c1 CHEMBL3932180 Ki 3.9 nM
Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)OC(C)(C)C)c1nnc(C)n1-2 CHEMBL1957266 IC50 3.9 nM
COc1ccc(C(C)(C)O)cc1-c1cn(C)c(=O)c2[nH]c(C(=O)NCc3ccc(C(=O)Nc4ccccc4N)cc3)cc12 CHEMBL4763504 IC50 3.9 nM
COc1nnc2ccc(N3CCC(c4ccc(N5CC(CN6CCN(C)C(=O)[C@H]6C)C5)cc4)CC3)nn12 CHEMBL4453435 pIC50 3.981 nM
CCOc1ccc2c(c1)C(c1cn[nH]c1)=CN(C)C(=O)[C@@H]2C CHEMBL5218813 pIC50 3.981 nM
CCS(=O)(=O)Nc1ccc(Oc2ccc(C#N)cc2)c(-c2cn(C)c(=O)c3[nH]ccc23)c1 CHEMBL3933860 Ki 4.0 nM
Cn1cc(-c2cc(S(=O)(=O)Nc3ccc(F)cc3)ccc2OCC2CC2)c2cc[nH]c2c1=O CHEMBL3903136 Ki 4.0 nM
COCCN1CCC(Nc2cc(-c3cn(C)nc3Cc3ccccc3)nn3c(C)nnc23)CC1 CHEMBL3967321 IC50 4.0 nM
Cc1noc(C)c1-c1cc(C(O)(c2nccs2)c2nccs2)c2nc(C3CC3)[nH]c2c1 CHEMBL3945286 IC50 4.0 nM
COc1cc2c(cc1-c1c(C)noc1C)[nH]c1nc(C)nc(Nc3cc(C)nn3C3CCCC3)c12 CHEMBL4167996 IC50 4.0 nM
CC(=O)N1c2ccc(-c3ccc(C(=O)NCCOCCOCCOCC(=O)N[C@H](C(=O)N4C[C@H](O)C[C@H]4C(=O)NCc4ccc(-c5scnc5C)cc4)C(C)(C)C)cc3)cc2[C@H](Nc2ccc(Cl)cc2)C[C@@H]1C CHEMBL4229193 Kd 4.0 nM
Cc1nnn(C)c1-c1ccc2c3ncc(C(C)(C)O)cc3n([C@H](c3ccccc3)C3CCOCC3)c2c1F CHEMBL5084636 IC50 4.0 nM
Cc1nnn(C)c1-c1cnc2c3ccc(C(C)C)cc3n([C@H](c3ccccc3)C3CCOCC3)c2c1 CHEMBL5172933 IC50 4.0 nM
Cn1cc(-c2cc(S(C)(=O)=O)ccc2OCC2CC2)c2cc[nH]c2c1=O CHEMBL3908231 Ki 4.1 nM
CCS(=O)(=O)Nc1cnc2c(c1)-c1cn(C)c(=O)c3[nH]cc(c13)CN2c1ccc(F)cc1F CHEMBL4213045 IC50 4.1 nM
Cc1cc2n3c(c[nH]c(=O)c13)CN(C(=O)c1ccc3sccc3c1)c1ccc(CS(C)(=O)=O)cc1-2 CHEMBL5424066 IC50 4.1 nM
Cn1cc(-c2cc(C(=O)NC3CCCC3)ccc2Oc2ccccc2)c2cc[nH]c2c1=O CHEMBL3928495 Ki 4.2 nM
Cn1cc(-c2cc(C(N)=O)ccc2Oc2ccccc2)c2cc[nH]c2c1=O CHEMBL3914893 Ki 4.2 nM
Cn1cc(-c2cc(S(C)(=O)=O)ccc2Oc2cccc(F)c2)c2cc[nH]c2c1=O CHEMBL3900464 Ki 4.2 nM
CCS(=O)(=O)c1ccc(NC2CC2)c(-c2cn(C)c(=O)c3[nH]ccc23)c1 CHEMBL3976953 Ki 4.2 nM
CCS(=O)(=O)c1ccc(OCC2CC2(F)F)c(-c2cn(C)c(=O)c3[nH]c(C(=O)NCC(F)(F)F)cc23)c1 CHEMBL3931182 Ki 4.2 nM
CCS(=O)(=O)Nc1ccc(Oc2ccc(F)cc2F)c(-c2cn(C)c(=O)c3[nH]c(CO)cc23)c1 CHEMBL3913918 Ki 4.2 nM
COc1cc2c(cc1-c1c(C)noc1C)[nH]c1ncnc(-c3c(C)[nH]c4cnccc34)c12 CHEMBL4210062 Ki 4.2 nM
COc1cc(-c2nc(C)nc3[nH]c4cc(-c5c(C)noc5C)c(OC)cc4c23)c2ccccc2n1 CHEMBL4218757 Ki 4.2 nM
Cc1nnc2n1-c1sc(C#Cc3ccncc3)c(Cc3ccccc3)c1COC2 CHEMBL4532913 Ki 4.2 nM
Cc1cc(-c2cc(CS(C)(=O)=O)ccc2Oc2ccc(F)cc2F)n2cc[nH]c(=O)c12 CHEMBL4461077 IC50 4.2 nM
Cc1ccc(-n2nc(C(=O)N3CCN(C)CC3)nc2-c2ccc3c(c2)N(C2CCCC2)[C@H](C)C(=O)N3C)cc1F CHEMBL4550548 IC50 4.2 nM
Cc1noc(C)c1-c1ccc2c(c1)C(c1ccccc1)N(Cc1cn(CCOCCn3cc(CN4C(=O)N(C)c5ccc(-c6c(C)noc6C)cc5C4c4ccccc4)nn3)nn1)C(=O)N2C CHEMBL4793308 IC50 4.2 nM
Cc1noc(C)c1-c1cc(C(N)=O)c2c3cc(C(=O)N4C[C@@H](C)O[C@@H](C)C4)ccc3n(Cc3ccccc3)c2c1 CHEMBL5074438 IC50 4.2 nM
CCS(=O)(=O)Cc1cc(-c2cc(C)c(=O)n(C)c2)cc2c1[nH]c(=O)n2Cc1ccccc1 CHEMBL5406585 IC50 4.2 nM
Cn1cc(-c2cc(C(=O)NCC(F)F)ccc2Oc2ccccc2)c2cc[nH]c2c1=O CHEMBL3896993 Ki 4.3 nM
CCS(=O)(=O)Nc1ccc2c(c1)-c1c[nH]c(=O)c3c1c(cn3C)CN2c1ccc(F)cc1 CHEMBL4218411 IC50 4.3 nM
CCNC(=O)c1cc2c(-c3cc(S(C)(=O)=O)ccc3Nc3c(C)cccc3C)cn(C)c(=O)c2[nH]1 CHEMBL4568610 Ki 4.3 nM
CNS(=O)(=O)Nc1ccc(OC2CCC(F)(F)CC2)c(-c2cn(C)c(=O)c3[nH]ccc23)c1 CHEMBL3891958 Ki 4.4 nM
Cc1ccc(Oc2ccc(S(C)(=O)=O)cc2-c2cn(C)c(=O)c3[nH]ccc23)cc1 CHEMBL3982212 Ki 4.4 nM
Cn1cc(-c2cc(NS(=O)(=O)CC(F)(F)F)ccc2Oc2ccccc2)c2cc[nH]c2c1=O CHEMBL3904317 Ki 4.4 nM
CCOc1cc(=O)n(C)cc1-c1cc(NS(=O)(=O)CC)ccc1Oc1ccccc1 CHEMBL4078875 Ki 4.4 nM
COc1cc2c(cc1-c1c(C)noc1C)[nH]c1nc(C)nc(Nc3cc(C)nn3C(C)(C)C)c12 CHEMBL4171109 IC50 4.4 nM
CCS(=O)(=O)Nc1cnc2c(c1)-c1c[nH]c(=O)c3c1c(cn3C)CN2c1ccc(F)cc1F CHEMBL4206058 Ki 4.4 nM
Cc1noc(C)c1-c1cc(C(N)=O)c2c3ccc(C(C)(C)O)cc3n(Cc3ccccc3)c2c1 CHEMBL3786449 IC50 4.4 nM
CNS(=O)(=O)c1cnc(NCC2CC2)c(-c2cn(C)c(=O)c3[nH]ccc23)c1 CHEMBL3978601 Ki 4.5 nM
Cn1cc(-c2cc(S(C)(=O)=O)ccc2Oc2cccc(Cl)c2F)c2cc[nH]c2c1=O CHEMBL3908833 Ki 4.5 nM
Cn1cc(-c2cc(CS(C)(=O)=O)cnc2Oc2ccc(F)cc2F)c2cc[nH]c2c1=O CHEMBL3907464 Ki 4.5 nM
Cc1ccc(-n2nc(C(=O)N3CCN(C)CC3)nc2-c2ccc3c(c2)N(C2CCCC2)[C@H](C)C(=O)N3C)c(C)c1 CHEMBL4587000 IC50 4.5 nM
Cc1noc(C)c1-c1cc(C(N)=O)c2c3cc(C(C)(C)O)ccc3n(Cc3ccccc3)c2c1 CHEMBL5074708 IC50 4.5 nM
CCOc1cc(=O)n(C)cc1-c1cc(N(Cc2nccs2)S(=O)(=O)CC)ccc1Oc1ccc(F)cc1F CHEMBL3964415 Ki 4.58 nM
Cn1cc(-c2cc(S(C)(=O)=O)ccc2Oc2ccc3ncccc3c2)c2cc[nH]c2c1=O CHEMBL3974181 Ki 4.6 nM
CNS(=O)(=O)c1cnc(Oc2ccc(F)cc2F)c(-c2cn(C)c(=O)c3[nH]ccc23)c1 CHEMBL3897307 Ki 4.6 nM
CCS(=O)(=O)c1ccc(N2CCCC2)c(-c2cn(C)c(=O)c3[nH]ccc23)c1 CHEMBL3908414 Ki 4.6 nM
Cn1cc2c3c(c[nH]c3c1=O)CN(CC1CC1)c1ccc(CS(C)(=O)=O)cc1-2 CHEMBL4212062 IC50 4.6 nM
Cc1ccc(-n2nc(C(=O)N3CCCN(C)CC3)nc2-c2ccc3c(c2)N(C2CCCC2)[C@H](C)C(=O)N3C)cc1 CHEMBL4449874 IC50 4.6 nM
Cc1ccc(-n2nc(C(=O)N3CC4CCC(C3)N4C)nc2-c2ccc3c(c2)N(C2CCCC2)[C@H](C)C(=O)N3C)cc1 CHEMBL4583525 IC50 4.6 nM
Cc1noc(C)c1-c1cc(C(O)(c2ncccn2)c2ccc(F)cc2F)c2nc(C3CC3)[nH]c2c1 CHEMBL3893098 IC50 4.7 nM
CCS(=O)(=O)Cc1ccc(Oc2ccc(F)cc2F)c(-c2cc(C)c3c(=O)[nH]ccn23)c1 CHEMBL4522212 IC50 4.7 nM
Cn1cc(-c2cc(S(C)(=O)=O)ccc2Oc2ccccc2Cl)c2cc[nH]c2c1=O CHEMBL3979562 Ki 4.8 nM
CCS(=O)(=O)N(CC1CC1)c1ccc(Oc2ccc(F)cc2F)c(-c2cn(C)c(=O)c3[nH]ccc23)c1 CHEMBL3924634 Ki 4.8 nM
Cc1ccc(-n2nc(C(=O)N3CCN(C(C)C)CC3)nc2-c2ccc3c(c2)N(C2CCCC2)[C@H](C)C(=O)N3C)cc1 CHEMBL4518804 IC50 4.8 nM
Cn1cc(-c2ccccc2Oc2ccccc2)c2cc(C(=O)NCCCCC(=O)NO)[nH]c2c1=O CHEMBL4800001 IC50 4.8 nM
Cc1cnc(Nc2ccc(C(=O)NC3CCN(C(=O)COCCOCCOCC(=O)N4CCC(NC(=O)c5ccc(Nc6ncc(C)c(Nc7ccc(Cl)c(NS(=O)(=O)C(C)(C)C)c7)n6)cc5F)CC4)CC3)c(F)c2)nc1Nc1ccc(Cl)c(NS(=O)(=O)C(C)(C)C)c1 CHEMBL5204093 Kd 4.8 nM
CCS(=O)(=O)Cc1cc(-c2cc(C)c(=O)n(C)c2)cc2c1n(C)c(=O)n2Cc1ccccc1 CHEMBL5404986 IC50 4.8 nM
CNS(=O)(=O)Nc1ccc(Oc2ccc(F)cc2F)c(-c2cn(C)c(=O)c3[nH]ccc23)c1 CHEMBL3920048 Ki 4.9 nM
COc1cc2c(cc1-c1c(C)noc1C)[nH]c1nc(C)nc(Nc3nn(C)c4ncccc34)c12 CHEMBL4177214 Ki 4.9 nM
COc1cc2c(cc1-c1c(C)noc1C)[nH]c1nc(C)nc(Nc3c4c(nn3C)CCCC4)c12 CHEMBL4161145 IC50 4.9 nM
CC(C)COc1ccc(S(C)(=O)=O)cc1-c1cn(C)c(=O)c2[nH]ccc12 CHEMBL3947757 Ki 5.0 nM
Cn1cc(-c2cc(S(=O)(=O)N3CCCC3)ccc2Oc2ccc(F)cc2F)c2cc[nH]c2c1=O CHEMBL3889659 Ki 5.0 nM
Cc1cc(-c2nc3cc4c(C)nn(C)c4cc3n2[C@@H](C)c2ccccc2)cn(C)c1=O CHEMBL4082119 IC50 5.0 nM
Cc1[nH]c2ccccc2c1CCNCc1ccc(/C=C/C(=O)NO)cc1 CHEMBL483254 IC50 5.0 nM
COc1cc2c(cc1-c1c(C)noc1C)[nH]c1nc(C)nc(Nc3nn(C)c4c3CCCC4)c12 CHEMBL4169068 IC50 5.0 nM
CCCOc1ccc(S(C)(=O)=O)cc1-c1cn(C)c(=O)c2ccc(-c3cnn(C)c3)cc12 CHEMBL4227387 IC50 5.0 nM
Cc1nnc2c(NC(C)C)nc(-c3nc4ccc(N5CCOCC5)cc4n3Cc3ccccn3)cn12 CHEMBL3939182 IC50 5.0 nM
Cc1c(C(=O)NCCCCCNc2cccc3c2C(=O)N(C2CCC(=O)NC2=O)C3=O)sc2c1C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)OC(C)(C)C)c1nnc(C)n1-2 CHEMBL5275867 DC50 5.0 nM
CCn1nc(C2CC2)cc1Nc1nc(C(=O)NCCCOCCOCCOCCCNc2cccc3c2C(=O)N(C2CCC(=O)NC2=O)C3=O)nc2[nH]c3cc(-c4c(C)noc4C)c(OC)cc3c12 CHEMBL5266070 DC50 5.0 nM
Cc1noc(C)c1-c1ccc2c(c1)c(Cc1ccc(F)cc1)cn2CCCCCCC(=O)NO CHEMBL4454646 IC50 5.0 nM
COCC(COC)n1c(-c2cc(C)c(=O)n(C)c2)nc2cc(N3CCOCC3)ccc21 CHEMBL4438171 pKd 5.012 nM
COc1nnc2ccc(N3CCC(c4ccc(OCCN5C[C@@H](C)N(C(C)=O)[C@@H](C)C5)cc4)CC3)nn12 CHEMBL4460682 pKi 5.012 nM
CCN(CC(c1ccccc1)c1ccccc1)C(=O)c1cc(C)c(=O)n(C)c1 CHEMBL4854203 pIC50 5.012 nM
CNC(=O)[C@H](C1CCOCC1)N(CC(c1ccccc1)c1ccccn1)C(=O)c1cc(C)c(=O)n(C)c1 CHEMBL4852928 pIC50 5.012 nM
CNC(=O)c1cc(C(=O)Nc2cnn(C)c2)cc2c1OC[C@H]2c1ccccc1 CHEMBL4853098 pIC50 5.012 nM
CC(=O)N1c2ccc(C(N)=O)cc2[C@H](Nc2ncc(Cl)cn2)C[C@@H]1C CHEMBL5195288 pKd 5.012 nM
COCCS(=O)(=O)Nc1ccc(Oc2ccc(F)cc2F)c(-c2cn(C)c(=O)c3[nH]ccc23)c1 CHEMBL3891226 Ki 5.1 nM
CCOc1cc(=O)n(C)cc1-c1cc(NS(=O)(=O)CC)ccc1Oc1ccc(F)cc1F CHEMBL4082889 Ki 5.1 nM
Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)NCCCCCCCCNC(=O)COc1cccc3c1C(=O)N(C1CCC(=O)NC1=O)C3=O)c1nnc(C)n1-2 CHEMBL4303781 DC50 5.1 nM
CCS(=O)(=O)Cc1ccc(Oc2ccc(F)cc2F)c(-c2cn(C)c(=O)c3[nH]ccc23)c1 CHEMBL3937631 Ki 5.2 nM
Cc1ccc(-n2c(C)nnc2-c2ccc3c(c2)N(C2CCCC2)[C@H](C)C(=O)N3C)cc1 CHEMBL4463165 IC50 5.2 nM
CC(=O)Nc1ccc(Oc2ccccc2)c(-c2cn(C)c(=O)c3[nH]ccc23)c1 CHEMBL3928793 Ki 5.3 nM
Cc1ccc(-n2nc(C(=O)N3C[C@@H](C)N[C@@H](C)C3)nc2-c2ccc3c(c2)N(C2CCCC2)[C@H](C)C(=O)N3C)cc1 CHEMBL4451357 IC50 5.3 nM
Cn1cc(-c2ccccc2Oc2ccccc2)c2cc(C(=O)NCCCCCCC(=O)NO)[nH]c2c1=O CHEMBL4798212 IC50 5.3 nM
CCS(=O)(=O)Nc1ccc(Oc2cncnc2)c(-c2cn(C)c(=O)c3[nH]ccc23)c1 CHEMBL3967185 Ki 5.4 nM
CN1CCC(NC(=O)c2ccc(Oc3ccc(F)cc3F)c(-c3cn(C)c(=O)c4[nH]ccc34)c2)C1=O CHEMBL3954903 Ki 5.4 nM
Cn1cc(-c2cc(S(=O)(=O)N3CCOCC3)ccc2OCC2CC2)c2cc[nH]c2c1=O CHEMBL3907963 Ki 5.4 nM
Cc1ccc(-n2nc(C(=O)N3CCN(C)CC3)nc2-c2ccc3c(c2)N(C2CCCC2)[C@H](C)C(=O)N3C)cc1 CHEMBL4573400 IC50 5.4 nM
Cc1noc(C)c1-c1cc(C(N)=O)c2c3ccc(C(C)(C)O)cc3n([C@@H](c3ccccc3)C3CCOCC3)c2c1 CHEMBL5075046 IC50 5.4 nM
Cn1cc(-c2cc(C(=O)NCC3CCCO3)ccc2Oc2ccccc2)c2cc[nH]c2c1=O CHEMBL3891527 Ki 5.5 nM
Cn1cc(-c2cc(S(C)(=O)=O)ccc2Oc2cccc3cnccc23)c2cc[nH]c2c1=O CHEMBL3903237 Ki 5.5 nM
CCS(=O)(=O)Nc1ccc(Oc2ccc(F)cc2)c(-c2cn(C)c3c(=O)[nH]ccc23)c1 CHEMBL4064089 Ki 5.5 nM
CCOc1cc(=O)n(C)cc1-c1cc(NS(=O)(=O)CC)ccc1Oc1ccc(OC(F)(F)F)cc1 CHEMBL4083819 Ki 5.5 nM
COc1cc2c(cc1-c1c(C)noc1C)[nH]c1nc(C)nc(Nc3c4c(nn3C)CCC4)c12 CHEMBL4172447 IC50 5.5 nM
CC(=O)Nc1cccc(CN2c3ccccc3C=C3c4c(cccc42)C(=O)N3C)c1 CHEMBL5414323 IC50 5.5 nM
CNS(=O)(=O)c1cnc(OC2CCOC2)c(-c2cn(C)c(=O)c3[nH]ccc23)c1 CHEMBL3979883 Ki 5.6 nM
CNS(=O)(=O)c1cnc(OCC2CC2)c(-c2cn(C)c(=O)c3[nH]ccc23)c1 CHEMBL3927745 Ki 5.6 nM
CCOc1cc(=O)n(C)cc1-c1cc(NS(=O)(=O)CC)ccc1Oc1ccc(F)cc1 CHEMBL4063808 Ki 5.6 nM
Cc1noc(C)c1-c1ccc2c(c1)C(c1ccccc1)N(CC(=O)N1CCN(c3ccc4nnc(Cl)n4n3)CC1)C(=O)N2C CHEMBL4867171 IC50 5.6 nM
Cc1ccc(-n2c(C)nnc2-c2ccc3c(c2)N(C2CC2)C(C)C(=O)N3C)cc1 CHEMBL4578490 IC50 5.7 nM
Cn1cc(-c2cc(S(N)(=O)=O)cnc2Oc2ccc(F)cc2F)c2cc[nH]c2c1=O CHEMBL3911074 Ki 5.8 nM
CCNC(=O)c1cc2c(-c3cc(S(=O)(=O)CC)ccc3Oc3c(C)cccc3C(F)(F)F)cn(C)c(=O)c2[nH]1 CHEMBL4547415 Ki 5.8 nM
CCN1CCN(C(=O)c2nc(-c3ccc4c(c3)N(C3CCCC3)[C@H](C)C(=O)N4C)n(-c3ccc(C)cc3)n2)CC1 CHEMBL4561468 IC50 5.8 nM
Cn1cc(-c2cc(C(C)(C)O)ccc2OC2CC2)c2cc(C(=O)NCCCCCCC(=O)NO)[nH]c2c1=O CHEMBL4784336 IC50 5.8 nM
COCCNC(=O)c1cccc(CN2c3ccccc3C=C3c4c(cccc42)C(=O)N3C)c1 CHEMBL5421082 IC50 5.8 nM
CCOC(=O)N1CCC(Oc2ccc(S(C)(=O)=O)cc2-c2cn(C)c(=O)c3[nH]ccc23)CC1 CHEMBL3923948 Ki 5.9 nM
Cn1cc(-c2cc(S(C)(=O)=O)ccc2Oc2ccc3ccncc3c2)c2cc[nH]c2c1=O CHEMBL3982460 Ki 5.9 nM
Cc1noc(C)c1-c1cc(C(O)(c2ccccn2)c2ncccn2)c2nc(C3CC3)[nH]c2c1 CHEMBL3930041 IC50 5.9 nM
Cc1ccc(-n2nc(C(=O)N3CCN(C4CC4)CC3)nc2-c2ccc3c(c2)N(C2CCCC2)[C@H](C)C(=O)N3C)cc1 CHEMBL4445973 IC50 5.9 nM
COCCNC(=O)c1cccc(CN2c3cccc4c3C(=Cc3cccnc32)N(C)C4=O)c1 CHEMBL5430174 IC50 5.9 nM
Cn1cc(-c2cc(S(C)(=O)=O)ccc2Oc2cc(F)cc(F)c2)c2cc[nH]c2c1=O CHEMBL3969220 Ki 6.0 nM
Cc1nnn2c1-c1ccc(-c3ccc(N)nc3)cc1N(c1ccc(Cl)cc1)CC2 CHEMBL4168815 IC50 6.0 nM
Cc1nnn2c1-c1ccc(C(=O)N[C@@H](C)c3ccccc3)cc1N(c1ccc(Cl)cc1)CC2 CHEMBL4162832 IC50 6.0 nM
Cc1nnn2c1-c1ccc(-c3ccc(N)nc3)cc1C(c1ccc(Cl)cc1)=NC2 CHEMBL4279393 IC50 6.0 nM
Cc1cc(-c2ccc3nc(-c4cnn(CC(C)(C)O)c4)nc(N4CCOC[C@@H]4c4ccc(F)cc4)c3c2)cn(C)c1=O CHEMBL4761474 IC50 6.0 nM
CC(C)Oc1ccc(C(C)(C)O)cc1-c1cn(C)c(=O)c2[nH]c(C(=O)NCCCCCCC(=O)NO)cc12 CHEMBL4755061 IC50 6.0 nM
COC(=O)C(Cc1c[nH]cn1)NC(=O)C[C@@H]1N=C(c2ccc(Cl)cc2)c2c(sc(C)c2C)-n2c(C)nnc21 CHEMBL5399489 IC50 6.0 nM
CN1CCN(C(=O)c2cc3c(-c4cc(S(C)(=O)=O)ccc4Oc4ccc(F)cc4F)cn(C)c(=O)c3[nH]2)CC1 CHEMBL3965455 Ki 6.1 nM
Cn1nc(-c2cc(NS(C)(=O)=O)ccc2Oc2ccccc2)c2cc[nH]c2c1=O CHEMBL3974976 Ki 6.1 nM
Cn1cc(-c2cc(S(=O)(=O)Nc3ccccc3)ccc2OCC2CC2)c2cc[nH]c2c1=O CHEMBL3906205 Ki 6.1 nM
COc1cc2c(cc1-c1c(C)noc1C)[nH]c1nc(C)nc(Nc3cc(C(C)C)nn3C)c12 CHEMBL4176849 IC50 6.1 nM
Cc1ccc(-n2nc(C(=O)N3C[C@@H](N)C4(CC4)C3)nc2-c2ccc3c(c2)N(C2CCCC2)[C@H](C)C(=O)N3C)cc1 CHEMBL4582401 IC50 6.1 nM
Cc1cc2n3c(c[nH]c(=O)c13)CN(C(=O)c1cccc3sccc13)c1ccc(CS(C)(=O)=O)cc1-2 CHEMBL5422361 IC50 6.1 nM
Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=NC(CC(=O)NCCCN1CCN(C)CC1)c1nnc(C)n1-2 CHEMBL3979024 IC50 6.13 nM
Cn1cc(-c2cc(S(C)(=O)=O)ccc2OC2CCOC2)c2cc[nH]c2c1=O CHEMBL3958767 Ki 6.2 nM
Cc1ccc(-n2nc(C(=O)N3CCN(C(=O)c4nc(-c5ccc6c(c5)N(C5CCCC5)[C@H](C)C(=O)N6C)n(-c5ccc(C)cc5)n4)CC3)nc2-c2ccc3c(c2)N(C2CCCC2)[C@H](C)C(=O)N3C)cc1 CHEMBL5416632 IC50 6.2 nM
Cn1cc(-c2cc(S(C)(=O)=O)ccc2OC2Cc3ccccc3C2)c2cc[nH]c2c1=O CHEMBL3946189 Ki 6.3 nM
COc1cc2c(cc1-c1c(C)noc1C)[nH]c1nc(C)nc(Nc3cc(C)n(C)n3)c12 CHEMBL4175855 Ki 6.3 nM
COc1nnc2ccc(N3CCC(c4ccc(OCCCCN5CCN(C)C(=O)[C@H]5C)cc4)CC3)nn12 CHEMBL4593653 pKi 6.31 nM
Cc1cc2c(-c3ccco3)cnc(N[C@@H]3CCN(C)C[C@H]3C(=O)NC3CCCCC3)c2[nH]c1=O CHEMBL4648362 pKd 6.31 nM
CNC(=O)c1cc(C(=O)N[C@H]2[C@@H]3COC[C@@H]32)cc2c1OC[C@H]2c1cccc2[nH]ccc12 CHEMBL4874566 pIC50 6.31 nM
CNC(=O)c1cc(C(=O)NC2CC2)cn(Cc2ccccc2)c1=O CHEMBL4635134 pKd 6.31 nM
Cn1cc(-c2cc(NS(C)(=O)=O)ccc2Oc2ccccc2C(F)(F)F)c2cc[nH]c2c1=O CHEMBL4060619 Ki 6.4 nM
Cc1nnn(C2CCN(CCN(C)C)CC2)c1-c1cccc(Oc2cc(Br)ccc2Br)n1 CHEMBL5080584 Kd 6.4 nM
Cc1cccc(C(=O)N2Cc3c[nH]c(=O)c4c(C)cc(n34)-c3cc(CS(C)(=O)=O)ccc32)c1C CHEMBL5429506 IC50 6.4 nM
COC(=O)c1cccc(C(=O)N2Cc3c[nH]c(=O)c4c(C)cc(n34)-c3cc(CS(C)(=O)=O)ccc32)c1 CHEMBL5425218 IC50 6.4 nM
CCS(=O)(=O)Nc1ccc(OCc2ccnn2C)c(-c2cn(C)c(=O)c3[nH]ccc23)c1 CHEMBL3960737 Ki 6.5 nM
Cn1cc(-c2cc(S(C)(=O)=O)ccc2NC2CCOC2)c2cc[nH]c2c1=O CHEMBL3904424 Ki 6.5 nM
CCS(=O)(=O)Nc1ccc(Oc2ccc(F)cc2F)c(-c2nn(C)c(=O)c3[nH]ccc23)c1 CHEMBL3979084 Ki 6.5 nM
Cn1cc(-c2cc(S(=O)(=O)N3CC(F)(F)C3)ccc2OCC2CC2)c2cc[nH]c2c1=O CHEMBL3922190 Ki 6.5 nM
COc1cc2c(cc1-c1c(C)noc1C)[nH]c1ncnc(-c3cnn4ccccc34)c12 CHEMBL4211972 Ki 6.5 nM
Cn1cc(-c2cc(S(C)(=O)=O)ccc2Oc2cc(F)ccc2F)c2cc[nH]c2c1=O CHEMBL3952841 Ki 6.6 nM
Cc1ccc(-n2nc(C(=O)N3C4CCC3CN(C)C4)nc2-c2ccc3c(c2)N(C2CCCC2)[C@H](C)C(=O)N3C)cc1 CHEMBL4553774 IC50 6.6 nM
CC(=O)NCC#Cc1ccc(C2=N[C@@H](CC(=O)OC(C)(C)C)c3nnc(C)n3-c3sc(C)c(C)c32)cc1 CHEMBL4798393 IC50 6.6 nM
CC(=O)N1c2ccc(C3=CCNCC3)cc2N(Cc2ccccc2CO)C[C@@H]1C1CC1 CHEMBL4218735 pKd 6.607 nM
CC[C@@H]1c2nnc(C)n2-c2cnc(Nc3ccc(C(=O)NC4CCN(C)CC4)cc3OC)nc2N1C1CCCC1 CHEMBL4776770 IC50 6.7 nM
Cc1cnc(Nc2ccc(C(=O)NC3CCN(C)CC3)c(F)c2)nc1Nc1ccc(Cl)c(NS(=O)(=O)C(C)(C)C)c1 CHEMBL4760892 Kd 6.7 nM
C[C@@H]1C(=O)N(C)c2ccc(-c3nc(C(=O)N4CCN(C)CC4)nn3-c3ccc(Cl)cc3)cc2N1C1CCCC1 CHEMBL4441607 IC50 6.8 nM
Cn1cc(-c2cc(S(C)(=O)=O)ccc2OCC2CCCCC2)c2cc[nH]c2c1=O CHEMBL3985085 Ki 6.9 nM
Cc1cc(F)cc(C)c1Oc1ccc(C(C)(C)O)cc1-c1cn(C)c(=O)c2[nH]c(C(=O)NC(C)(C)C(F)(F)F)cc12 CHEMBL4584480 Ki 6.9 nM
CC[C@@H]1c2nncn2-c2cnc(Nc3ccc(C(=O)NC4CCN(C)CC4)cc3OC)nc2N1Cc1ccsc1 CHEMBL4755706 IC50 6.9 nM
Cn1cc(-c2cc(C(C)(C)O)ccc2OC2CC2)c2cc(C(=O)NCc3ccc(C(=O)NO)cc3)[nH]c2c1=O CHEMBL4781215 IC50 6.9 nM
Cn1cc(-c2cc(NS(=O)(=O)C3CC3)ccc2Oc2ccc(F)cc2F)c2cc[nH]c2c1=O CHEMBL3915758 Ki 7.0 nM
CCS(=O)(=O)Nc1ccc(Oc2ccc(F)cc2F)c(-c2cn(C)c(=O)cc2OCC(C)C)c1 CHEMBL4102713 Ki 7.0 nM
Cc1nnn2c1-c1ccc(-c3cc[nH]n3)cc1N(c1ccc(Cl)cc1)CC2 CHEMBL4177080 IC50 7.0 nM
Cc1ccc(-c2ccc3c(c2)N(c2ccc(Cl)cc2)CCn2nnc(C)c2-3)cn1 CHEMBL4173305 IC50 7.0 nM
Cc1nnn2c1-c1ccc(C(=O)NS(C)(=O)=O)cc1N(c1ccc(Cl)cc1)CC2 CHEMBL4167362 IC50 7.0 nM
Cc1nnn2c1-c1ccccc1N(c1ccc(Cl)cc1)C[C@H]2C CHEMBL4170756 IC50 7.0 nM
COc1cc2c(cc1-c1c(C)noc1C)[nH]c1ncnc(-c3c[nH]c4cnccc34)c12 CHEMBL4218866 Ki 7.0 nM
Cc1ccc(-n2nc(C(=O)N(C)CCN(C)C)nc2-c2ccc3c(c2)N(C2CCCC2)[C@H](C)C(=O)N3C)cc1 CHEMBL4577433 IC50 7.0 nM
Cc1noc2c1-c1ccc(-c3ccc(N)nc3)cc1C(c1ccc(Cl)cc1)=N[C@H]2CC(N)=O CHEMBL5271336 IC50 7.0 nM
CN(C)c1cccc(Oc2ccc(S(C)(=O)=O)cc2-c2cn(C)c(=O)c3[nH]ccc23)c1 CHEMBL3923219 Ki 7.1 nM
Cn1cc2c3c(c[nH]c3c1=O)CN(C(=O)C1CC1)c1ccc(CS(C)(=O)=O)cc1-2 CHEMBL4202833 Ki 7.1 nM
C[C@@H]1C(=O)N(C)c2ccc(-c3nc(C(=O)N4CCN(C)CC4)nn3-c3ccccc3)cc2N1C1CCCC1 CHEMBL4452579 IC50 7.1 nM
Cc1cc(-c2ccc3nc(C4CCOCC4)n(CCOC(F)(F)F)c3c2)cn(C)c1=O CHEMBL5274024 Kd 7.1 nM
Cc1noc(C)c1-c1cc(C(O)(c2ccccn2)c2ccccn2)c2nc(C3CC3)[nH]c2c1 CHEMBL3982690 IC50 7.2 nM
Cc1sc2c(c1C)C(c1ccc(C#CCNC(=N)N)cc1)=N[C@@H](CC(=O)OC(C)(C)C)c1nnc(C)n1-2 CHEMBL4751308 IC50 7.2 nM
Cn1cc(-c2cc(C(C)(C)O)ccc2Oc2ccc(F)cc2F)c2cc(C(=O)NCCCCCCC(=O)NO)[nH]c2c1=O CHEMBL4749756 IC50 7.2 nM
Cn1cc(-c2cc(C(=O)N3CCN(C(=O)c4ccco4)CC3)ccc2Oc2ccc(F)cc2F)c2cc[nH]c2c1=O CHEMBL3976575 Ki 7.3 nM
CCS(=O)(=O)c1ccc2c(c1)-c1cn(C)c(=O)cc1OCCCc1ccccc1O2 CHEMBL4068991 Ki 7.3 nM
CCC(=O)N1Cc2c[nH]c3c(=O)n(C)cc(c23)-c2cc(CS(C)(=O)=O)ccc21 CHEMBL4217818 Ki 7.3 nM
Cn1cc(-c2cc(CN[SH](=O)=O)ccc2Oc2ccccc2C(F)(F)F)c2cc[nH]c2c1=O CHEMBL3973801 Ki 7.5 nM
Cn1cc(-c2cc(S(=O)(=O)c3ccccc3)ccc2OCC2CC2)c2cc[nH]c2c1=O CHEMBL3978444 Ki 7.5 nM
CCCS(=O)(=O)Nc1ccc(Oc2ccc(C#N)cc2)c(-c2cn(C)c(=O)c3[nH]ccc23)c1 CHEMBL3985704 Ki 7.6 nM
Cn1cc2c3c(c[nH]c(=O)c31)-c1cc(CS(C)(=O)=O)ccc1N(C(=O)C1CC1)C2 CHEMBL4203764 Ki 7.7 nM
Cc1noc(C)c1-c1ccc2c(c1)C(c1ccccc1)N(Cc1cn(CCOCCOCCOCCn3cc(CN4C(=O)N(C)c5ccc(-c6c(C)noc6C)cc5C4c4ccccc4)nn3)nn1)C(=O)N2C CHEMBL4778807 IC50 7.7 nM
Cc1noc(C)c1-c1ccc2c(c1)C(c1ccccc1)N(Cc1cn(CCOCCOCCOCCn3cc(CC4C(=O)N(C)c5ccc(-c6c(C)noc6C)cc5N4c4ccccc4)nn3)nn1)C(=O)N2C CHEMBL5196787 IC50 7.7 nM
Cn1cc(-c2cc(C(C)(C)O)ccc2OC2CC2)c2cc(C(=O)NCc3ccc(C(=O)NCCCCNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)cc3)[nH]c2c1=O CHEMBL5169455 IC50 7.79 nM
CN(C)S(=O)(=O)c1cnc(Oc2ccc(F)cc2F)c(-c2cn(C)c(=O)c3[nH]ccc23)c1 CHEMBL3906617 Ki 7.8 nM
Cc1ccc(-n2nc(C(=O)N3CCC4(CCOC4)CC3)nc2-c2ccc3c(c2)N(C2CCCC2)[C@H](C)C(=O)N3C)cc1 CHEMBL4584184 IC50 7.9 nM
C[C@@H]1C(=O)N(C)CCN1CCOc1ccc(C2CCN(c3ccc4nnc(C(F)(F)F)n4n3)CC2)cc1 CHEMBL4448398 pKi 7.943 nM
COc1nnc2ccc(N3CCC(c4ccc(OCCN5[C@H](C)CN(C)C(=O)[C@H]5C)cc4)CC3)nn12 CHEMBL4457035 pKi 7.943 nM
CNC(=O)CN(CC(c1ccccc1)c1ccccc1)C(=O)c1cc(C)c(=O)n(C)c1 CHEMBL4857388 pIC50 7.943 nM
Cc1cc(C(=O)N(CC(N)=O)CC(c2ccccc2)c2ccccc2)cn(C)c1=O CHEMBL4863889 pIC50 7.943 nM
COCC(COC)N(CC(c1ccccc1)c1ccccc1)C(=O)c1cc(C)c(=O)n(C)c1 CHEMBL4878095 pIC50 7.943 nM
CNC(=O)[C@@H](C1CCOCC1)N(CC(c1ccccc1)c1ccccn1)C(=O)c1cc(C)c(=O)n(C)c1 CHEMBL4869314 pIC50 7.943 nM
CNC(=O)c1cc(C(=O)NC2CC2)cc2c1OC[C@H]2c1cccc2[nH]ccc12 CHEMBL4869239 pIC50 7.943 nM
CCOc1ccc2c(c1)C(c1cnn(C)c1)=CN(C)C(=O)[C@@H]2C CHEMBL5219991 pIC50 7.943 nM
Cc1cc(-c2nc3ccccc3n2C[C@@H]2CCCN(C(=O)C3CCN(C(C)C)CC3)C2)cn(C)c1=O CHEMBL5405343 pKd 7.943 nM
Cc1cc(-c2nc3cnc(C4CCOCC4)cc3n2[C@@H](C)c2ccccc2)nn(C)c1=O CHEMBL3787279 IC50 8.0 nM
Cc1noc(C)c1-c1ccc2c(c1)C(c1ccsc1)(N1CCC[C@H](N)C1)C(=O)N2 CHEMBL3787210 IC50 8.0 nM
COCCN1CCC(Nc2cc(-c3cnn(C)c3Oc3ccccc3)nn3c(C)nnc23)CC1 CHEMBL3912279 IC50 8.0 nM
Cc1nnc2c(NC3CCN(C)CC3)cc(-c3cnn(C)c3Oc3ccccc3)nn12 CHEMBL3937670 IC50 8.0 nM
CC(=O)N1c2ccc(-c3ccc(C(=O)NCCOCCOCCOCCOCC(=O)N[C@H](C(=O)N4C[C@H](O)C[C@H]4C(=O)NCc4ccc(-c5scnc5C)cc4)C(C)(C)C)cc3)cc2[C@H](Nc2ccc(Cl)cc2)C[C@@H]1C CHEMBL4226376 Kd 8.0 nM
Cc1noc(C)c1-c1cc(N)c2ncn(Cc3ccccc3)c2c1 CHEMBL4244412 IC50 8.0 nM
Cc1noc(C)c1-c1ccc2c(c1)C(C1CCCC1)(N1CCC[C@H](N)C1)C(=O)N2 CHEMBL4442201 IC50 8.0 nM
CNc1nc(-c2nn(C)c(C)c2Oc2ccccc2)cn2c(C)nnc12 CHEMBL3929450 IC50 8.0 nM
CC[C@@H]1c2nncn2-c2cnc(Nc3ccccc3OC)nc2N1C1CCCC1 CHEMBL4796137 IC50 8.0 nM
[2H]C([2H])([2H])c1nnn(C)c1-c1cnc2c3c(F)cc(C(C)(C)O)cc3n([C@H](c3ccccc3)C3CCOCC3)c2c1 CHEMBL5171108 IC50 8.0 nM
CCNC(=O)c1cccc(CN2c3cccc4c3C(=Cc3cccnc32)N(C)C4=O)c1 CHEMBL5438020 IC50 8.0 nM
Cn1cc(-c2cc(C(N)=O)ccc2Oc2ccc(F)cc2F)c2cc[nH]c2c1=O CHEMBL3912882 Ki 8.1 nM
Cn1cc(-c2cc(S(C)(=O)=O)ccc2Oc2ccc(F)cc2)c2cc[nH]c2c1=O CHEMBL3954042 Ki 8.1 nM
Cc1sc2c(c1C)C(c1ccc(C#CC(C)(C)N)cc1)=N[C@@H](CC(=O)OC(C)(C)C)c1nnc(C)n1-2 CHEMBL4745517 IC50 8.1 nM
Cn1cc(-c2cc(S(C)(=O)=O)ccc2Oc2cccc(Cl)c2)c2cc[nH]c2c1=O CHEMBL3955197 Ki 8.2 nM
Cc1ccc(F)cc1Oc1ccc(S(C)(=O)=O)cc1-c1cn(C)c(=O)c2[nH]ccc12 CHEMBL3917701 Ki 8.2 nM
CCS(=O)(=O)Nc1ccc(Oc2ccccc2)c(-c2cn(C)c(=O)cc2OC)c1 CHEMBL4103153 Ki 8.2 nM
CC(=O)Nc1cc(-c2cn(C)c3c(=O)[nH]ccc23)cc2c1ccn2C(C)(c1ccccn1)c1ccccn1 CHEMBL4640025 IC50 8.3 nM
Cn1cc(-c2ccccc2Oc2ccccc2)c2cc(C(=O)NCCCCCC(=O)Nc3ccccc3N)[nH]c2c1=O CHEMBL4750537 IC50 8.4 nM
Cn1cc(-c2cc(C(=O)O)ccc2Oc2ccccc2)c2cc[nH]c2c1=O CHEMBL3905932 Ki 8.6 nM
Cc1ccc(-n2cnnc2-c2ccc3c(c2)N(C2CC2)C(C)C(=O)N3C)cc1 CHEMBL4585487 IC50 8.6 nM
CC[C@@H]1C(=O)N(C)c2cnc(Nc3ccc(C(=O)NC4CCN(C)CC4)cc3OC)nc2N1Cc1cccc(Br)c1 CHEMBL3609308 Ki 8.7 nM
Cn1cc(-c2cc(S(N)(=O)=O)cnc2Nc2ccccc2)c2cc[nH]c2c1=O CHEMBL3895136 Ki 8.7 nM
Cn1cc(-c2cc(S(C)(=O)=O)ccc2Oc2ccc(F)cc2F)c2cc(C(=O)NCC(F)(F)F)[nH]c2c1=O CHEMBL3909584 Ki 8.7 nM
CCOc1cc(=O)n(C)cc1-c1cc(NS(=O)(=O)CC)cnc1Oc1ccc(F)cc1F CHEMBL4059680 Ki 8.7 nM
Cc1ccc(-n2nc(C(=O)N3CCN4CCCC4C3)nc2-c2ccc3c(c2)N(C2CCCC2)[C@H](C)C(=O)N3C)cc1 CHEMBL4454674 IC50 8.7 nM
Cc1cc(OCC2CC2)c(-c2cn(C)c(=O)c3[nH]ccc23)cc1NS(C)(=O)=O CHEMBL3899717 Ki 8.8 nM
Cn1cc(-c2cc(S(C)(=O)=O)ccc2Oc2ccc3c(c2)CCC3)c2cc[nH]c2c1=O CHEMBL3950445 Ki 8.8 nM
Cc1noc(C)c1-c1ccc2c(c1)C(c1ccccc1)N(CCCCCN1CCN(c3ccc4nnc(Cl)n4n3)CC1)C(=O)N2C CHEMBL4865930 IC50 8.8 nM
Cn1cc(-c2cc(CS(C)(=O)=O)ccc2Oc2ccc(F)cc2F)c2cc[nH]c2c1=O CHEMBL3970135 Ki 8.9 nM
Cn1cc(-c2cc(S(C)(=O)=O)ccc2NCC2CC2)c2cc[nH]c2c1=O CHEMBL3978817 Ki 8.9 nM
CCS(=O)(=O)N1CCN(C(=O)c2ccc(Oc3ccc(F)cc3F)c(-c3cn(C)c(=O)c4[nH]ccc34)c2)CC1 CHEMBL3953396 Ki 8.9 nM
CCS(=O)(=O)c1cnc2c(c1)-c1cn(C)c(=O)cc1OCCCCc1cc(Cl)ccc1O2 CHEMBL4075757 Ki 8.9 nM
CC[C@@H]1c2nncn2-c2cnc(Nc3ccc(C(=O)NN4CCN(C)CC4)cc3OC)nc2N1CC1CCCCC1 CHEMBL4750219 IC50 8.9 nM
COc1cc2c(cc1-c1c(C)noc1C)ncc1[nH]c(=O)n([C@H](C)c3ccccn3)c12 CHEMBL2017291 Ki 9.0 nM
Cc1nnc2c(NC(C)C)nc(-c3nc4cnc(N5CCOC[C@@H]5C)cc4n3C(C)CC3CC3)cn12 CHEMBL3785917 IC50 9.0 nM
CCS(=O)(=O)c1ccc(OC2CCS(=O)(=O)CC2)c(-c2cn(C)c(=O)c3[nH]ccc23)c1 CHEMBL3923025 Ki 9.0 nM
CCS(=O)(=O)c1ccc(Oc2ccc(C#N)cc2)c(-c2cn(C)c(=O)c3[nH]ccc23)c1 CHEMBL3907725 Ki 9.0 nM
CCS(=O)(=O)Nc1ccc(Oc2ccc(C(F)(F)F)cc2)c(-c2cn(C)c(=O)c3[nH]ccc23)c1 CHEMBL4059602 Ki 9.0 nM
Cc1nnc2c(NC(C)C)nc(-c3nc4cnc(N5CCOC[C@H]5C)cc4n3C(C)CC3CC3)cn12 CHEMBL4097251 IC50 9.0 nM
Cc1nnc2c(Nc3cccc(CNC(=O)C(C)C)c3)nc3ccccc3n12 CHEMBL4083840 Kd 9.0 nM
CCS(=O)(=O)Nc1ccc(Oc2ccc(F)cc2F)c(-c2cn(C)c(=O)cc2OC2COC2)c1 CHEMBL4083186 Ki 9.0 nM
CCOc1ccc(S(C)(=O)=O)cc1-c1cn(C)c(=O)c2ccc(-c3cnn(C)c3)cc12 CHEMBL4226540 IC50 9.0 nM
CNc1nc(-c2nc3ccc(N4CCN(C)CC4)cc3n2Cc2ccccc2)cn2c(C)nnc12 CHEMBL3919831 IC50 9.0 nM
CC(=O)Nc1c(F)cc(C(=O)N[C@H]2CC[C@H](O)CC2)cc1O[C@@H](C)c1ccccc1 CHEMBL4636881 Kd 9.0 nM
CCS(=O)(=O)Nc1cc(-c2c(C)nn(C)c2C)c(F)c(-c2ccnc3nc[nH]c23)c1 CHEMBL5399435 Ki 9.0 nM
Cc1noc(C)c1-c1ccc2c(c1)C(c1ccccc1)N(CCCCCC(=O)N1CCN(c3ccc4nnc(Cl)n4n3)CC1)C(=O)N2C CHEMBL4863343 IC50 9.2 nM
CCOc1cc(=O)n(C)cc1-c1cc(NC(=O)COCc2ccccc2)ccc1Oc1ccc(F)cc1F CHEMBL3950632 Ki 9.36 nM
Cc1ccc(-n2nc(C(=O)N3CCN(C)CC3)nc2-c2ccc3c(c2)N(C2CC2)C(C)C(=O)N3C)cc1 CHEMBL4556261 IC50 9.4 nM
CCC(c1ccccn1)(c1ccccn1)n1ccc2c(NS(=O)(=O)CC)cc(-c3cn(C)c4c(=O)[nH]ccc34)cc21 CHEMBL4647718 IC50 9.4 nM
Cn1cc(-c2cc(S(C)(=O)=O)ccc2Oc2ccc(F)cc2F)c2cc[nH]c2c1=O CHEMBL3948752 Ki 9.5 nM
Cc1nnc2n1-c1sc(C#CC3CCC3)c(Cc3ccccc3)c1COC2 CHEMBL4458148 Ki 9.5 nM
Cc1cc(-c2cc(NS(C)(=O)=O)ccc2OC2CCCCC2)n2cc[nH]c(=O)c12 CHEMBL4539863 IC50 9.5 nM
Cc1ccc(-n2nnnc2-c2ccc3c(c2)N(C2CCCC2)C(C)C(=O)N3C)cc1 CHEMBL4537909 IC50 9.5 nM
Cc1noc(C)c1-c1cc(C(N)=O)c2c3ccc(C(C)(C)O)cc3n(CC3CCOCC3)c2c1 CHEMBL5075119 IC50 9.5 nM
CC(C)c1ccc(Oc2ccc(S(C)(=O)=O)cc2-c2cn(C)c(=O)c3[nH]ccc23)cc1 CHEMBL3926264 Ki 9.6 nM
Cc1nnc2n1-c1sc(C#CC3CCOCC3)c(Cc3ccccc3)c1COC2 CHEMBL4441402 Ki 9.6 nM
Cc1ccc(-n2nc(C(=O)N3C[C@@H](NC(=O)OC(C)(C)C)C4(CC4)C3)nc2-c2ccc3c(c2)N(C2CCCC2)[C@H](C)C(=O)N3C)cc1 CHEMBL4445310 IC50 9.6 nM
CCOc1cc(=O)n(C)cc1-c1cc(N(Cc2ccccc2)S(=O)(=O)CC)ccc1Oc1ccc(F)cc1F CHEMBL3930821 Ki 9.66 nM
Cn1cc(-c2cc(C(=O)NC3CCOC3)ccc2Oc2ccc(F)cc2F)c2cc[nH]c2c1=O CHEMBL3949648 Ki 9.7 nM
Cn1cc(-c2cc(S(C)(=O)=O)ccc2Oc2ccc3c(c2)C(=O)CC3)c2cc[nH]c2c1=O CHEMBL3965721 Ki 9.7 nM
COc1cc(OC)c2c(=O)[nH]c(-c3cc(OC)c(OC(=O)C(C)(C)Oc4ccc(Cl)cc4)c(OC)c3)nc2c1 CHEMBL4473057 IC50 9.7 nM
CCc1cccc(CC)c1Oc1ccc(NS(=O)(=O)CC)cc1-c1cn(C)c(=O)c2cc(-c3cc(C)c(OCCO)c(C)c3)oc12 CHEMBL5200030 IC50 9.7 nM
CC[C@@H]1c2nncn2-c2cnc(Nc3ccc(C(=O)NC4CCN(C)CC4)cc3OC)nc2N1CC1CCCCC1 CHEMBL4758859 IC50 9.8 nM
Cn1cc(-c2cc(S(=O)(=O)N3CCc4ccccc43)ccc2Oc2ccc(F)cc2F)c2cc[nH]c2c1=O CHEMBL3968656 Ki 9.9 nM
CNC(=O)N1N=C(c2ccc(N3CCN(C(=O)COCCOCC(=O)Nc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)cc2)c2cc(OC)c(OC)cc2C[C@@H]1C CHEMBL4854720 IC50 9.9 nM