Cn1ncc(Nc2ccc(CCN)cc2)c(Br)c1=O CHEMBL4861491 Kd 0.24 nM
Cn1ncc(Nc2ccc(CCN)cc2)c(Cl)c1=O CHEMBL4872300 Kd 0.47 nM
COc1cc(-c2cn(C)c(=O)c3cnccc23)cc(OC)c1CN(C)C CHEMBL3823478 Kd 0.75 nM
COc1cc(-c2cn(C)c(=O)c3cnccc23)cc(OC)c1CN1CCN(CCCCCOc2cc(-c3scnc3C)ccc2CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C2(F)CC2)C(C)(C)C)CC1 CHEMBL5182441 DC50 1.76 nM
CCn1cc(-c2cccc(C(F)(F)F)c2)c2sc(C(=N)NC3CCS(=O)(=O)CC3)cc2c1=O CHEMBL3769507 pKd 1.995 nM
C/C=C/Cn1cc(-c2cc(OC)c(C(=O)N3CCOCC3)cc2OC)c2cc[nH]c2c1=O CHEMBL4635496 pKd 1.995 nM
C/C=C/Cn1cc(-c2cc(OC)c(C(=O)N3CCOCC3)cc2OC)c2cc(C)[nH]c2c1=O CHEMBL5268484 Kd 2.0 nM
COc1ccc(S(=O)(=O)N2CC3(COC3)C2)cc1NC(=O)c1[nH]c(C)c2c1CCCCC2=O CHEMBL4776447 Kd 4.3 nM
Cn1c(=O)ccc2ccccc21 CHEMBL216146 Kd 5.0 nM
C/C=C/Cn1cc(-c2cc(OC)c(C(C)(C)O)cc2OC)c2cc(C)[nH]c2c1=O CHEMBL5289762 Kd 5.0 nM
COc1cc(-c2cn(C)c(=O)c3cnccc23)c(OC)cc1CN(C)C CHEMBL3823101 Kd 5.9 nM
C/C=C/Cn1cc(-c2ccc(C(=O)N3CCOCC3)c(OC)c2)c2cc(C)[nH]c2c1=O CHEMBL5279182 IC50 6.0 nM
C/C=C/Cn1cc(-c2ccc(C(=O)N3CCOCC3)c(Cl)c2)c2cc(C)[nH]c2c1=O CHEMBL5285110 IC50 7.0 nM
COc1ccc(-c2cn(C)c(=O)c3cc(C(=N)NC4CCS(=O)(=O)CC4)sc23)cc1OC CHEMBL3770188 pIC50 7.943 nM
C/C=C/Cn1cc(-c2ccc(C(=O)N3CCOCC3)c(C#N)c2)c2cc(C)[nH]c2c1=O CHEMBL5268936 IC50 8.0 nM
COc1cc(-c2cc(C)c(=O)n(C)c2)cc(OC)c1CN1CC(N)C1 CHEMBL3823177 IC50 9.0 nM
C/C=C/Cn1cc(-c2ccc(C(=O)N3CCOCC3)c(C)c2)c2cc(C)[nH]c2c1=O CHEMBL5280605 IC50 9.0 nM
CN(C)c1cccc(-c2cn(C)c(=O)c3cc(C(=N)NC4CCS(=O)(=O)CC4)sc23)c1 CHEMBL3769944 pIC50 10.0 nM
CCCCn1cc(-c2cccc(C(F)(F)F)c2)c2sc(C(=N)NC3CCS(=O)(=O)CC3)cc2c1=O CHEMBL4642341 pKi 10.0 nM
C/C=C/Cn1cc(-c2ccc(C(=O)N3CCOCC3)cc2)c2cc(C)[nH]c2c1=O CHEMBL5284261 IC50 12.0 nM
COc1ccc(-c2cn(C)c(=O)c3cc(C(=O)NC4CCS(=O)(=O)CC4)sc23)cc1OC CHEMBL3769688 pIC50 12.59 nM
COc1cccc(-c2cn(C)c(=O)c3cc(C(=N)NC4CCS(=O)(=O)CC4)sc23)c1 CHEMBL3769855 pIC50 12.59 nM
COc1cc(-c2cn(C)c(=O)c3cnccc23)cc(OC)c1CN1CCN(CCOCCOCC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)NCc2ccc(-c3scnc3C)cc2)C(C)(C)C)CC1 CHEMBL5274606 Kd 15.0 nM
Cn1cc(-c2cccc(C(F)(F)F)c2)c2sc(C(=N)NC3CCS(=O)(=O)CC3)cc2c1=O CHEMBL3770949 pIC50 15.85 nM
COc1cc(-c2cc(C)c(=O)n(C)c2)cc(OC)c1CN1CC(O)C1 CHEMBL3823369 IC50 21.0 nM
C/C=C/Cn1cc(-c2ccc(C(=O)N3CCOCC3)cc2)c2cc[nH]c2c1=O CHEMBL5270178 Kd 21.0 nM
C/C=C/Cn1cc(-c2ccc(C(C)(C)O)cc2OC)c2cc[nH]c2c1=O CHEMBL5282240 Kd 25.0 nM
COc1cc(-c2cn(C)c(=O)c3ccccc23)cc(OC)c1CN(C)C CHEMBL3824146 IC50 30.0 nM
CC(=O)c1cc(-c2cc(C(=O)NC3CC3)ccc2C)c2ncccn12 CHEMBL4065619 pKd 31.62 nM
C/C=C/Cn1cc(-c2ccc(C(=O)N3CCNCC3)c(Cl)c2)n2cncc2c1=O CHEMBL4557699 IC50 35.0 nM
COc1cc(-c2cn(C)c(=O)c3cncnc23)cc(OC)c1CN(C)C CHEMBL3824312 IC50 37.0 nM
COc1cc(-c2cn(C)c(=O)c(C)c2C)cc(OC)c1CN(C)C CHEMBL3823599 IC50 37.0 nM
Cn1cc(-c2ccccc2)c2sc(C(=N)NC3CCS(=O)(=O)CC3)cc2c1=O CHEMBL3769509 pIC50 39.81 nM
Cn1cc(-c2cccc(C#N)c2)c2sc(C(=N)NC3CCS(=O)(=O)CC3)cc2c1=O CHEMBL3769628 pIC50 39.81 nM
Cc1c(NCc2ccccc2N2CCN(C)CC2)cnn(C)c1=O CHEMBL4648548 pKi 39.81 nM
C/C=C/Cc1c(NCc2ccccc2N2CCN(C)CC2)cnn(C)c1=O CHEMBL4645418 pKi 39.81 nM
Cc1cc2c(C3=CCOCC3)cnc(NC3CCN(C(=O)C(F)(F)CN)CC3)c2[nH]c1=O CHEMBL4864027 pKi 39.81 nM
CCOC(=O)Nc1cc(-c2ccc(C)c(NS(C)(=O)=O)c2)nn2c(C)nnc12 CHEMBL3133807 Kd 41.7 nM
C/C=C/Cn1cc(-c2ccc(C(C)(C)O)cc2)c2cc[nH]c2c1=O CHEMBL5286608 IC50 53.0 nM
COc1cc(-c2cc(C)c(=O)n(C)c2)cc(OC)c1CN(C)C CHEMBL3822990 IC50 54.0 nM
COc1cc(-c2cc(C)c(=O)n(C)c2C)cc(OC)c1CN(C)C CHEMBL3823697 IC50 57.0 nM
Cc1c(NCc2ccccc2N2CCN(CCCN)CC2)cnn(C)c1=O CHEMBL4644816 pIC50 63.1 nM
CCCCc1c(NCc2ccccc2N2CCN(C)CC2)cnn(C)c1=O CHEMBL4639574 pKi 63.1 nM
COc1ccc(S(=O)(=O)N2CCOCC2)cc1NC(=O)c1[nH]c(C)c2c1CCCCC2=O CHEMBL4762147 Kd 67.0 nM
Cc1[nH]c(-c2cc(N)ccc2Cl)c2c1C(=O)CCCC2 CHEMBL5439294 Kd 67.0 nM
CC(=O)c1cc(-c2cccc3nccn23)c2cc(N3CCOCC3)ccn12 CHEMBL3740819 Kd 68.0 nM
COc1ccc(S(=O)(=O)N2CCN(C)CC2)cc1NC(=O)c1[nH]c(C)c2c1CCCCC2=O CHEMBL4762202 Kd 68.0 nM
CNC(=N)c1cc2c(=O)n(C)cc(-c3ccc(OC)c(OC)c3)c2s1 CHEMBL3770367 pIC50 79.43 nM
CCc1c(NCc2ccccc2N2CCN(C)CC2)cnn(C)c1=O CHEMBL4635895 pKi 79.43 nM
CCCCc1c(Nc2cccc3c2CCN(C)C3)cnn(C)c1=O CHEMBL4643740 pKi 79.43 nM
Cc1cc(=O)n(C)c2cc(N3C(=O)CC[C@H](NS(=O)(=O)CC(C)C)[C@H]3c3ccc(Cl)cc3)ccc12 CHEMBL3753082 Kd 99.0 nM
Cc1c(NCc2ccccc2-c2ccccc2)cnn(C)c1=O CHEMBL4633192 pIC50 100.0 nM
Cc1c(NCc2ccccc2N2CCOCC2)cnn(C)c1=O CHEMBL4645392 pIC50 100.0 nM
Cc1c(NCc2ccccc2N2CCCOCC2)cnn(C)c1=O CHEMBL4643455 pIC50 100.0 nM
C=CCc1c(NCc2ccccc2N2CCN(C)CC2)cnn(C)c1=O CHEMBL4642886 pKi 100.0 nM
C/C=C/Cn1cc(-c2ccc(C(=O)N3CCN(S(C)(=O)=O)CC3)c(Cl)c2)n2cncc2c1=O CHEMBL4559707 IC50 103.0 nM
CNC(=O)c1cc2c(=O)n(C)cc(-c3ccc(OC)c(OC)c3)c2s1 CHEMBL3770039 pIC50 125.89 nM
CCCc1c(NCc2ccccc2N2CCN(C)CC2)cnn(C)c1=O CHEMBL4644517 pKi 125.89 nM
COc1cc(-c2cn(C)c(=O)c3ccncc23)cc(OC)c1CN(C)C CHEMBL3823859 IC50 128.0 nM
COc1ccc(-c2cn(C)c(=O)c3ccccc23)c(OC)n1 CHEMBL5434122 Ki 130.0 nM
COc1cc(-c2cn(C)c(=O)c3ccccc23)c(OC)cc1CN(C)C CHEMBL3824133 IC50 134.0 nM
COc1cc(-c2cc(C)c(=O)n(C)c2C)c(OC)cc1CN(C)C CHEMBL3824351 IC50 134.0 nM
COc1cc(-c2cn(C)c(=O)c3cccnc23)cc(OC)c1CN(C)C CHEMBL3822539 IC50 134.0 nM
CCc1nn(C)c(=O)n1-c1ccc2c(c1)OCO2 CHEMBL5414611 IC50 140.0 nM
CCCc1[nH]c(-c2cc(N)ccc2Cl)c2c1C(=O)CCCC2 CHEMBL5398641 Kd 150.0 nM
CCCCCc1c(NCc2ccccc2N2CCN(C)CC2)cnn(C)c1=O CHEMBL4634319 pKi 158.49 nM
Cc1c(Nc2cccc3c2CCN(C)C3)cnn(C)c1=O CHEMBL4645137 pKi 158.49 nM
C/C=C/Cn1cc(-c2cccc(C(=O)N(C)C)c2)c2cc[nH]c2c1=O CHEMBL4519632 IC50 160.0 nM
CCN(CC)S(=O)(=O)c1ccc(OC)c(NC(=O)c2[nH]c(C)c3c2CCCCC3=O)c1 CHEMBL4780011 Kd 160.0 nM
COc1cc2c(cc1NS(=O)(=O)c1ccc(C#N)cc1OC)cc(C)c(=O)n2C CHEMBL4103077 IC50 170.0 nM
Cc1cc(=O)n(C)c2cc(N3C(=O)CC[C@@H](NS(=O)(=O)CC(C)C)[C@@H]3c3ccc(Cl)cc3)ccc12 CHEMBL4650212 IC50 189.0 nM
CCc1cc(-c2cc(C)c(=O)n(C)c2)cc(OC)c1CN(C)C CHEMBL3824289 IC50 195.0 nM
Cc1nnc2c3ccccc3c(-c3ccc(N4CCOCC4)c(NS(=O)(=O)c4ccccc4Cl)c3)nn12 CHEMBL3108801 pIC50 199.53 nM
COc1ccc(-c2cn(C)c(=O)c3cc(C(=O)N4CCN(S(C)(=O)=O)CC4)sc23)cc1OC CHEMBL3769979 pIC50 199.53 nM
Cc1c(NCc2ccccc2N2CCNCC2)cnn(C)c1=O CHEMBL4646728 pIC50 199.53 nM
Cn1c(=O)ccc2cc(NS(=O)(=O)c3ccccc3)ccc21 CHEMBL4067436 IC50 220.0 nM
CN(C)C(=O)c1cccc(-c2cn(C)c(=O)c3[nH]ccc23)c1 CHEMBL4436408 IC50 230.0 nM
CN(C)CCCc1ccc(Nc2cnn(C)c(=O)c2Cl)cc1 CHEMBL4848701 Kd 230.0 nM
COc1ccc(-c2ccc3c(C)cc(=O)n(C)c3c2)c(C)n1 CHEMBL5413197 Ki 230.0 nM
COc1cc(-c2cn(C)c(=O)c3ncccc23)cc(OC)c1CN(C)C CHEMBL3822909 IC50 250.0 nM
C/C=C\Cc1c(NCc2ccccc2N2CCN(C)CC2)cnn(C)c1=O CHEMBL4636297 pKi 251.19 nM
C=C[C@@H](C)c1c(NCc2ccccc2N2CCN(C)CC2)cnn(C)c1=O CHEMBL4642556 pKi 251.19 nM
C/C=C/Cn1cc(-c2ccc(C(=O)N3CCC(C(N)=O)CC3)c(Cl)c2)n2cncc2c1=O CHEMBL4526986 IC50 262.0 nM
C=CCn1cc(-c2cccc(C(=O)N(C)C)c2)c2cc[nH]c2c1=O CHEMBL4460783 IC50 290.0 nM
COc1ccc(S(=O)(=O)N2CCCCC2)cc1NC(=O)c1[nH]c(C)c2c1CCCCC2=O CHEMBL4787841 Kd 300.0 nM
Cc1cc2cc(NS(=O)(=O)c3ccc(C#N)cc3)ccc2n(C)c1=O CHEMBL4102050 IC50 310.0 nM
Cc1nnc2c3ccccc3c(-c3ccc(N4CCOCC4)c(NS(C)(=O)=O)c3)nn12 CHEMBL3108800 pIC50 316.23 nM
C=C[C@H](C)c1c(NCc2ccccc2N2CCN(C)CC2)cnn(C)c1=O CHEMBL4646338 pKi 316.23 nM
CC(C)c1c(NCc2ccccc2N2CCN(C)CC2)cnn(C)c1=O CHEMBL4632508 pKi 316.23 nM
Cc1cc(C)cc(-c2cn(C)c(=O)c3ccccc23)c1 CHEMBL5407972 Ki 340.0 nM
COc1ccc(-n2c(C)nn(C)c2=O)cc1OC CHEMBL5410955 IC50 350.0 nM
Cc1ccccc1CNc1cnn(C)c(=O)c1C CHEMBL4645268 pIC50 398.11 nM
C=CCCc1c(NCc2ccccc2N2CCN(C)CC2)cnn(C)c1=O CHEMBL4635826 pKi 398.11 nM
COc1ccccc1C(=O)Nc1cc2cc(C)c(=O)n(C)c2cc1N1CCCC1 CHEMBL4078047 IC50 420.0 nM
C/C=C/Cn1cc(-c2ccc(C(=O)N3CCCC3)c(Cl)c2)n2cncc2c1=O CHEMBL4527001 IC50 438.0 nM
C/C=C/Cn1cc(-c2ccc(C(=O)N3CCOCC3)c(Cl)c2)n2cncc2c1=O CHEMBL4522325 IC50 465.0 nM
COc1cc(-c2cc(C)c(=O)n(C)c2)c(OC)cc1CN(C)C CHEMBL3823906 IC50 468.0 nM
COc1cc(-c2cc(C)c(=O)n(C)c2)ccc1CN(C)C CHEMBL3822988 IC50 470.0 nM
C/C=C/Cn1cc(-c2ccc(C(=O)NC3CCS(=O)(=O)CC3)c(Cl)c2)n2cncc2c1=O CHEMBL4483320 IC50 480.0 nM
Cc1cc(=O)n(C)c2cc(N3C(=O)CC[C@H](NC(=O)OC(C)(C)C)[C@H]3c3ccccc3)ccc12 CHEMBL3785162 Kd 493.0 nM
Cc1ccc(-c2nn3c(C)nnc3c3ccccc23)cc1NS(C)(=O)=O CHEMBL3110357 pIC50 501.19 nM
CC(=O)c1cc(-c2ccccn2)c2cc(N3CCOCC3)ccn12 CHEMBL3739482 pIC50 501.19 nM
CC(=O)c1cc(-c2cccc(C)n2)c2cc(N3CCOCC3)ccn12 CHEMBL3741195 pIC50 501.19 nM
COc1cc(-c2cn(C)c(=O)c(C)c2C)c(OC)cc1CN(C)C CHEMBL3823551 IC50 507.0 nM
COc1cc(C#N)ccc1S(=O)(=O)Nc1ccc2c(c1)cc(C)c(=O)n2C CHEMBL3752151 IC50 520.0 nM
COc1ccc(S(=O)(=O)N2CCCCCC2)cc1NC(=O)c1[nH]c(C)c2c1CCCCC2=O CHEMBL4778822 Kd 530.0 nM
C/C=C/Cn1cc(-c2ccc(C(=O)N3CCN(C)CC3)c(Cl)c2)n2cncc2c1=O CHEMBL4520599 IC50 557.0 nM
Cc1cc(=O)n(C)c2cc(N3CCCCC3=O)ccc12 CHEMBL5267719 Kd 612.0 nM
C=CCCn1cc(-c2cc(C(=O)N3CCOCC3)c3ncn(CC)c3c2)c2cc[nH]c2c1=O CHEMBL4453202 IC50 620.0 nM
COc1ccc(S(=O)(=O)Nc2cc(-c3nn4c(C)nnc4c4ccccc34)ccc2N2CCN(C)CC2)cc1 CHEMBL3110353 pIC50 630.96 nM
C/C=C/Cn1cc(-c2ccc(C(=O)N3CCN(S(C)(=O)=O)CC3)c(F)c2)n2cncc2c1=O CHEMBL4549494 IC50 652.0 nM
COc1ccc(-c2ccc3c(C)cc(=O)n(C)c3c2)c(OC)n1 CHEMBL5412877 Kd 655.0 nM
COc1cc(-c2cc(C)c(=O)n(C)c2)cc(C)c1CN(C)C CHEMBL3822501 IC50 656.0 nM
C[C@@H]1CC(=O)Nc2cccc(-c3ccc4c(c3)c(-c3cnn(C)c3)nn4C)c2N1 CHEMBL3814752 IC50 730.0 nM
CCCCn1cc(-c2ccc(C(=O)N3CCNCC3)c(Cl)c2)n2cncc2c1=O CHEMBL4543384 IC50 730.0 nM
C=CCCn1cc(-c2cc(C(=O)N3CCOCC3)c3ncn(C)c3c2)c2cc[nH]c2c1=O CHEMBL4513694 IC50 750.0 nM
C/C=C/Cn1cc(-c2ccc(C(=O)N3CCOCC3)cc2Cl)n2cncc2c1=O CHEMBL4535661 IC50 763.0 nM
Cc1ccc(CNc2cnn(C)c(=O)c2Cl)cc1 CHEMBL4639281 pIC50 794.33 nM
CCCCc1[nH]c(-c2cc(N)ccc2Cl)c2c1C(=O)CCCC2 CHEMBL5433870 Kd 800.0 nM
CCn1cc(-c2ccc(C(=O)N3CCNCC3)c(Cl)c2)n2cncc2c1=O CHEMBL4542104 IC50 802.0 nM
CCCCn1cc(-c2ccc(C(=O)N3CCOCC3)c(Cl)c2)n2cncc2c1=O CHEMBL4529127 IC50 827.0 nM
C/C=C/Cn1cc(-c2ccc(C(=O)N3CCN(S(C)(=O)=O)CC3)cc2Cl)n2cncc2c1=O CHEMBL4583337 IC50 840.0 nM
C=CCCn1cc(-c2ccc(Cl)c(C(=O)N3CCOCC3)c2)c2cc[nH]c2c1=O CHEMBL4441257 IC50 860.0 nM
C=CCCn1cc(-c2cc(N)cc(C(=O)N3CCOCC3)c2)c2cc[nH]c2c1=O CHEMBL4448345 IC50 880.0 nM
COc1cc2c(cc1NS(=O)(=O)c1ccc(C#N)cc1)c(C)cc(=O)n2C CHEMBL4096095 IC50 890.0 nM
C=CCCn1cc(-c2cccc(C(=O)N3CCN(CCO)CC3)c2)c2cc[nH]c2c1=O CHEMBL4470836 IC50 890.0 nM
C=CCCn1cc(-c2cccc(C(=O)N3CCN(C)CC3)c2)c2cc[nH]c2c1=O CHEMBL4572531 IC50 900.0 nM
Cn1c(=O)ccc2cc(NS(=O)(=O)c3ccc(C#N)cc3)ccc21 CHEMBL4076056 IC50 910.0 nM
CCCn1cc(-c2ccc(C(=O)N3CCNCC3)c(Cl)c2)n2cncc2c1=O CHEMBL4582127 IC50 930.0 nM
C=CCCn1cc(-c2cc(OC(F)F)cc(C(=O)N3CCOCC3)c2)c2cc[nH]c2c1=O CHEMBL4586175 IC50 960.0 nM
C/C=C/Cn1cc(-c2ccc(C(=O)N3CCOCC3)c(F)c2)n2cncc2c1=O CHEMBL4524188 IC50 967.0 nM
Cc1nnc2c3ccccc3c(-c3ccc(N4CCOCC4)c(NS(=O)(=O)c4ccc(Cl)cc4)c3)nn12 CHEMBL3108803 pIC50 1000.0 nM
C=CCCn1cc(-c2cccc(C(=O)N3CCCC3)c2)c2cc[nH]c2c1=O CHEMBL4483624 IC50 1000.0 nM
C=CCCn1cc(-c2ccc(C)c(C(=O)N3CCOCC3)c2)c2cc[nH]c2c1=O CHEMBL4465624 IC50 1000.0 nM
COc1ccccc1C(=O)Nc1cc2c(cc1N1CCCC1)n(C)c(=O)n2C CHEMBL3356143 Kd 1000.0 nM