COc1ccccc1C(=O)Nc1cc2c(cc1N1CCNC[C@H]1C)n(C)c(=O)n2C CHEMBL3828191 pKd 0.3162 nM
COc1ccccc1C(=O)Nc1cc2c(cc1N1CCCC1)n(C)c(=O)n2C CHEMBL3356143 Kd 0.32 nM
CCCOc1cc(OCCCCN(C)C)cc(Oc2cc3c(cc2NS(=O)(=O)c2ccc(OC)c(OC)c2)n(C)c(=O)n3C)c1 CHEMBL3774575 Kd 2.1 nM
COc1cc(C#N)ccc1S(=O)(=O)Nc1ccc2c(c1)cc(C)c(=O)n2C CHEMBL3752151 IC50 3.1 nM
COc1ccccc1C(=O)Nc1cc2c(cc1N1CCC[C@H]1C)n(C)c(=O)n2C CHEMBL3828311 pIC50 5.012 nM
Cc1cc2cc(NS(=O)(=O)c3ccc(C#N)cc3)ccc2n(C)c1=O CHEMBL4102050 IC50 7.9 nM
COc1ccccc1S(=O)(=O)Nc1ccc2c(c1)cc(C)c(=O)n2C CHEMBL4069814 IC50 9.0 nM
COc1cc(C#N)ccc1S(=O)(=O)Nc1cc(F)c2c(c1)cc(C)c(=O)n2C CHEMBL4105505 IC50 12.0 nM
COc1cc2c(cc1NS(=O)(=O)c1ccc(C#N)cc1OC)cc(C)c(=O)n2C CHEMBL4103077 IC50 12.0 nM
COc1cc2c(cc1NS(=O)(=O)c1ccc(C#N)cc1)cc(C)c(=O)n2C CHEMBL4059962 IC50 15.0 nM
CCn1c(=O)c(C)cc2cc(NS(=O)(=O)c3ccc(C#N)cc3)ccc21 CHEMBL4097011 IC50 15.0 nM
COc1ccccc1C(=O)Nc1cc2c(cc1N1CCC[C@@H]1C)n(C)c(=O)n2C CHEMBL3828008 pIC50 15.85 nM
COc1cc2c(cc1NS(=O)(=O)c1ccccc1)cc(C)c(=O)n2C CHEMBL4087315 IC50 17.0 nM
Cc1cc(=O)n(C)c2ccc(NS(=O)(=O)c3ccc(C#N)cc3)cc12 CHEMBL4061727 IC50 24.0 nM
COc1cc2c(ccc(=O)n2C)cc1NS(=O)(=O)c1ccccc1 CHEMBL4084805 IC50 29.0 nM
COc1ccccc1C(=O)Nc1cc2c(cc1OC(C)C)n(C)c(=O)n2C CHEMBL3828684 pIC50 31.62 nM
COc1ncccc1C(=O)Nc1cc2c(cc1OC(C)C)n(C)c(=O)n2C CHEMBL3827767 pIC50 31.62 nM
CC(C)Oc1cc2c(ccc(=O)n2C)cc1NS(=O)(=O)c1ccc(C#N)cc1 CHEMBL4079434 IC50 39.0 nM
Cn1c(=O)ccc2cc(NS(=O)(=O)c3ccc(C#N)cc3)ccc21 CHEMBL4076056 IC50 43.0 nM
Cn1c(=O)ccc2cc(NS(=O)(=O)c3ccc(Cl)c(Cl)c3)ccc21 CHEMBL4099455 IC50 44.0 nM
COc1ccccc1C(=O)Nc1cc2c(cc1N(C)C)n(C)c(=O)n2C CHEMBL3828194 pIC50 50.12 nM
COc1cc(C#N)ccc1S(=O)(=O)N(C)c1ccc2c(c1)cc(C)c(=O)n2C CHEMBL4068981 IC50 52.0 nM
COc1cc2c(ccc(=O)n2C)cc1NS(=O)(=O)c1ccc(C#N)cc1 CHEMBL4102751 IC50 53.0 nM
CCOc1cc2c(ccc(=O)n2C)cc1NS(=O)(=O)c1ccc(C#N)cc1 CHEMBL4103693 IC50 55.0 nM
Cn1c(=O)ccc2cc(NS(=O)(=O)c3cccc(C#N)c3)ccc21 CHEMBL4103432 IC50 56.0 nM
COc1cc2c(cc1NS(=O)(=O)c1ccc(C#N)cc1)c(C)cc(=O)n2C CHEMBL4096095 IC50 60.0 nM
Cn1c(=O)ccc2cc(NS(=O)(=O)c3ccc(C#N)c(Cl)c3)ccc21 CHEMBL4081438 IC50 62.0 nM
CC(C)Oc1cc2c(cc1NC(=O)c1ccccn1)n(C)c(=O)n2C CHEMBL3827114 pIC50 63.1 nM
Cn1c(=O)ccc2cc(NS(=O)(=O)c3ccccc3)ccc21 CHEMBL4067436 IC50 65.0 nM
COc1ccc(C(=O)NO)cc1S(=O)(=O)Nc1ccc2c(c1)cc(C)c(=O)n2C CHEMBL4786813 Kd 67.0 nM
COc1ccccc1C(=O)Nc1cc2c(cc1N1CCCCC1)n(C)c(=O)n2C CHEMBL1522313 pIC50 79.43 nM
COc1ccccc1C(=O)Nc1cc2c(cc1N1CCNCC1)n(C)c(=O)n2C CHEMBL3827560 pIC50 79.43 nM
COc1ccccc1C(=O)Nc1cc2c(cc1N1CCN[C@@H](C)C1)n(C)c(=O)n2C CHEMBL3828354 pIC50 79.43 nM
COc1cc2c(cc1NS(=O)(=O)c1ccc(Br)cc1C)n(C)c(=O)n2C CHEMBL3770173 IC50 80.0 nM
CCc1cc2cc(NS(=O)(=O)c3ccc(C#N)cc3OC)ccc2n(C)c1=O CHEMBL4073708 IC50 93.0 nM
COc1cccc(C(=O)Nc2cc3c(cc2N2CCCCC2)n(C)c(=O)n3C)c1 CHEMBL3356140 pIC50 100.0 nM
Cn1c(=O)n(C)c2cc(N3CCCCC3)c(NC(=O)c3ccccc3)cc21 CHEMBL1724375 pIC50 100.0 nM
CC(C)Oc1cc2c(cc1NC(=O)c1ccccc1OCC(N)=O)n(C)c(=O)n2C CHEMBL3827996 pIC50 100.0 nM
COCCOc1ccccc1C(=O)Nc1cc2c(cc1OC(C)C)n(C)c(=O)n2C CHEMBL3828500 pIC50 100.0 nM
CC(C)Oc1cc2c(cc1NC(=O)c1ccccc1OCC(=O)N(C)C)n(C)c(=O)n2C CHEMBL3828146 pIC50 100.0 nM
COc1cccnc1C(=O)Nc1cc2c(cc1OC(C)C)n(C)c(=O)n2C CHEMBL3828061 pIC50 100.0 nM
Cn1c(=O)ccc2cc(S(=O)(=O)Nc3ccc(C#N)cc3)ccc21 CHEMBL4064071 IC50 100.0 nM
CCN(c1ccc2c(c1)cc(C)c(=O)n2C)S(=O)(=O)c1ccc(C#N)cc1OC CHEMBL4064386 IC50 110.0 nM
COc1ccccc1C(=O)Nc1cc2c(cc1N1CCOCC1)n(C)c(=O)n2C CHEMBL1396002 pIC50 125.89 nM
COc1cc2c(cc1NC(=O)c1ccccc1OC)n(C)c(=O)n2C CHEMBL3356145 pIC50 125.89 nM
CC(C)Oc1cc2c(cc1NC(=O)c1ccccc1OCCO)n(C)c(=O)n2C CHEMBL3828449 pIC50 125.89 nM
CC(C)Oc1cc2c(cc1NC(=O)c1ccncn1)n(C)c(=O)n2C CHEMBL3827276 pIC50 125.89 nM
COc1ccccc1C(=O)Nc1cc2c(cc1N1CCNC[C@@H]1C)n(C)c(=O)n2C CHEMBL3828026 pIC50 125.89 nM
COc1ccccc1C(=O)Nc1cc2c(cc1N1CCN[C@H](C)C1)n(C)c(=O)n2C CHEMBL3827280 pIC50 125.89 nM
COc1ccc(Oc2cc3c(cc2NS(=O)(=O)c2ccc(OC)c(OC)c2)n(C)c(=O)n3C)cc1 CHEMBL3769965 Kd 137.0 nM
CN1C[C@H](Nc2cnn(C)c(=O)c2Br)C[C@H](c2ccccc2)C1 CHEMBL4069412 Ki 140.0 nM
CCOC(=O)Nc1cc(-c2ccc(C)c(NS(C)(=O)=O)c2)nn2c(C)nnc12 CHEMBL3133807 IC50 140.7 nM
CC(C)Oc1cc2c(cc1NC(=O)c1ccccc1OCC#N)n(C)c(=O)n2C CHEMBL3828399 pIC50 158.49 nM
COc1cc(C#N)ccc1S(=O)(=O)N(c1ccc2c(c1)cc(C)c(=O)n2C)C(C)C CHEMBL4085921 IC50 160.0 nM
COc1cc(C#N)ccc1S(=O)(=O)Nc1ccc2c(c1)cc(C(C)C)c(=O)n2C CHEMBL4065116 IC50 170.0 nM
Cc1cc2cc(NS(=O)(=O)c3ccc(C(=O)NO)cc3)ccc2n(C)c1=O CHEMBL4789481 Kd 175.2 nM
CCc1cc2cc(NS(=O)(=O)c3ccc(C#N)cc3)ccc2n(C)c1=O CHEMBL4080511 IC50 180.0 nM
Cc1cc2c(cc1N1C(=O)c3cccc4cc([N+](=O)[O-])cc(c34)C1=O)n(C)c(=O)n2C CHEMBL4068180 IC50 185.0 nM
Cc1cc2cc(N)ccc2n(C)c1=O CHEMBL4079041 IC50 190.0 nM
Cc1ccc(S(=O)(=O)Nc2ccc3c(c2)n(C)c(=O)n3C)c(C)c1 CHEMBL1444120 pIC50 199.53 nM
COc1ccccc1C(=O)Nc1cc2c(cc1N1CCN(C)CC1)n(C)c(=O)n2C CHEMBL3828504 pIC50 199.53 nM
COc1ccccc1C(=O)Nc1cc2cc(C)c(=O)n(C)c2cc1N1CCCC1 CHEMBL4078047 IC50 220.0 nM
Cc1cc2cc(NS(=O)(=O)c3cc(C(=O)NO)ccc3Cl)ccc2n(C)c1=O CHEMBL4782406 Kd 234.0 nM
CCc1cc2cc(NS(=O)(=O)c3ccc(C#N)cc3OC)ccc2n(CC)c1=O CHEMBL4067917 IC50 250.0 nM
Cc1c(NCc2ccccc2N2CCN(C)CC2)cnn(C)c1=O CHEMBL4648548 pKi 251.19 nM
Cn1c(=O)n(C)c2cc(NS(=O)(=O)c3ccc4c(c3)CCCO4)ccc21 CHEMBL3770971 IC50 270.0 nM
Cn1c(=O)n(C)c2cc(Oc3ccccc3)c(NS(=O)(=O)c3ccc(Cl)cc3)cc21 CHEMBL3770004 IC50 270.0 nM
CCOC(=O)Nc1cc(-c2ccc(C)cc2NS(C)(=O)=O)nn2c(C)nnc12 CHEMBL3818270 Kd 270.0 nM
Cn1c(=O)n(C)c2cc(NS(=O)(=O)c3ccc4c(c3)CCC4)ccc21 CHEMBL3771151 IC50 290.0 nM
COc1ccc(S(=O)(=O)Nc2cc3c(cc2Oc2ccccc2)n(C)c(=O)n3C)cc1OC CHEMBL3769887 IC50 290.0 nM
Cn1c(=O)n(C)c2cc(NS(=O)(=O)c3ccc4c(c3)CCC(C)(C)O4)ccc21 CHEMBL3771106 IC50 310.0 nM
Cc1ccccc1C(=O)Nc1cc2c(cc1N1CCCCC1)n(C)c(=O)n2C CHEMBL1357836 pIC50 316.23 nM
COc1cccc(C(=O)Nc2cc3c(cc2N2CCCC2)n(C)c(=O)n3C)c1 CHEMBL1701516 pIC50 316.23 nM
CC(C)Oc1cc2c(cc1NC(=O)c1ccccc1OCCN(C)C)n(C)c(=O)n2C CHEMBL3827554 pIC50 316.23 nM
CC(C)Oc1cc2c(cc1NC(=O)c1ccccc1OC1CCN(C)C1)n(C)c(=O)n2C CHEMBL3827750 pIC50 316.23 nM
Cn1c(=O)n(C)c2cc(NS(=O)(=O)c3ccc4c(c3)CCCC4)ccc21 CHEMBL1346130 IC50 330.0 nM
COc1ccc(S(=O)(=O)Nc2cc3c(cc2Oc2ccccc2)n(C)c(=O)n3C)cc1 CHEMBL3771002 IC50 340.0 nM
CCS(=O)(=O)Nc1cc(-c2cn(C)c3c(=O)[nH]ccc23)cc2c1ccn2C(C)(c1ccccn1)c1ccccn1 CHEMBL4648912 Kd 360.0 nM
Cn1c(=O)ccc2cc(NS(=O)(=O)C3CCCCC3)ccc21 CHEMBL4094867 IC50 380.0 nM
Cn1c(=O)n(C)c2cc(N3CCCCC3)c(NC(=O)Cc3ccccc3)cc21 CHEMBL3356142 pIC50 398.11 nM
CC(C)c1ccc(S(=O)(=O)Nc2ccc3c(c2)n(C)c(=O)n3C)cc1 CHEMBL3770886 IC50 420.0 nM
Cc1ccccc1S(=O)(=O)Nc1cc2c(cc1Oc1ccccc1)n(C)c(=O)n2C CHEMBL3770465 IC50 430.0 nM
COc1cccc(S(=O)(=O)Nc2cc3c(cc2Oc2ccccc2)n(C)c(=O)n3C)c1 CHEMBL3770391 IC50 430.0 nM
Cn1c(=O)ccc2cc(NS(=O)(=O)c3ccccc3C#N)ccc21 CHEMBL4070377 IC50 430.0 nM
CC(C)Oc1cc2c(cc1NC(=O)c1ccccc1)n(C)c(=O)n2C CHEMBL3827629 pIC50 501.19 nM
Cc1ccc(S(=O)(=O)Nc2cc3c(cc2Oc2ccccc2)n(C)c(=O)n3C)cc1 CHEMBL3771226 IC50 510.0 nM
Cn1c(=O)ccc2cc(NS(=O)(=O)C3CC3)ccc21 CHEMBL4078346 IC50 520.0 nM
Cc1cc2c(cc1N1C(=O)c3cccc4c(Cl)ccc(c34)C1=O)n(C)c(=O)n2C CHEMBL4075478 IC50 547.0 nM
COc1ccccc1S(=O)(=O)Nc1ccc2c3c(cc(-n4cnc(C)c4)nc13)C(=O)N2C CHEMBL4446421 IC50 567.5 nM
CN1CCN(c2cc3c(cc2N2C(=O)c4cccc5cccc(c45)C2=O)n(C)c(=O)n3C)CC1 CHEMBL4064184 IC50 578.0 nM
Cc1ccc(S(=O)(=O)Nc2ccc3c(c2)n(C)c(=O)n3C)cc1F CHEMBL3770652 IC50 590.0 nM
Cc1cc2c(cc1N1C(=O)c3cccc4c(Br)ccc(c34)C1=O)n(C)c(=O)n2C CHEMBL4086958 IC50 591.0 nM
CN(C)c1cc2c(cc1N1C(=O)c3cccc4cccc(c34)C1=O)n(C)c(=O)n2C CHEMBL4064292 IC50 630.0 nM
COc1ccccc1C(=O)Nc1cc2[nH]c(=O)n(C)c2cc1N1CCCCC1 CHEMBL3356138 pIC50 630.96 nM
Cn1c(=O)n(C)c2cc(N3CCCCC3)c(NC(=O)C(C)(C)C)cc21 CHEMBL3356141 pIC50 630.96 nM
COc1cccc(C(=O)Nc2cc3c(cc2N2CCOCC2)n(C)c(=O)n3C)c1 CHEMBL1361770 pIC50 630.96 nM
COc1ccc(Oc2cc3c(cc2NS(=O)(=O)c2ccccc2)n(C)c(=O)n3C)cc1 CHEMBL3770259 IC50 660.0 nM
COc1ccc(Oc2cc3c(cc2NS(=O)(=O)c2ccc(OC)cc2)n(C)c(=O)n3C)cc1 CHEMBL3770456 IC50 660.0 nM
COc1ccc(Oc2cc3c(cc2NS(=O)(=O)c2ccccc2C)n(C)c(=O)n3C)cc1 CHEMBL3771005 IC50 680.0 nM
CCN(CC)c1cc2c(cc1NC(=O)c1ccccc1OC)n(C)c(=O)c(=O)n2C CHEMBL4289527 IC50 770.0 nM
Cc1ccc(F)cc1S(=O)(=O)Nc1cc2c(cc1Oc1ccccc1)n(C)c(=O)n2C CHEMBL3770048 IC50 790.0 nM
Cn1c(=O)n(C)c2cc(N3CCCC3)c(NC(=O)Cc3ccccc3)cc21 CHEMBL3356144 pIC50 794.33 nM
CC(C)Oc1cc2c(cc1NC(=O)C1CCNC1)n(C)c(=O)n2C CHEMBL3828186 pIC50 794.33 nM
CC(C)Oc1cc2c(cc1NC(=O)c1ccncc1)n(C)c(=O)n2C CHEMBL3828546 pIC50 794.33 nM
Cn1c(=O)n(C)c2cc(N3C(=O)c4cccc5cccc(c45)C3=O)c(Br)cc21 CHEMBL4075962 IC50 855.0 nM
COc1ccc(C(=O)NO)cc1C(=O)Nc1ccc2c(c1)cc(C)c(=O)n2C CHEMBL4789607 Kd 857.0 nM
CC(C)c1cc2cc(NS(=O)(=O)c3ccc(C#N)cc3)ccc2n(C)c1=O CHEMBL4086558 IC50 870.0 nM
CN(c1ccc2c(ccc(=O)n2C)c1)S(=O)(=O)c1ccc(C#N)cc1 CHEMBL4095325 IC50 910.0 nM
CC(=O)Nc1cc2c(cc1OC(C)C)n(C)c(=O)n2C CHEMBL3828426 pIC50 1000.0 nM
CCN(C(=O)c1ccccc1OC)c1cc2c(cc1N1CCNC[C@H]1C)n(C)c(=O)n2C CHEMBL3827932 pIC50 1000.0 nM
COc1cc2c(ccc(=O)n2C)cc1N(C)S(=O)(=O)c1ccc(C#N)cc1 CHEMBL4090059 IC50 1000.0 nM
Cn1c(=O)ccc2cc(S(=O)(=O)Nc3ccccc3)ccc21 CHEMBL4072276 IC50 1000.0 nM