CC(C)(N)/C=C(/C#N)C(=O)N1CCC[C@@H]1Cn1nc(-c2ccc(Oc3ccccc3)cc2F)c2c(N)ncnc21 CHEMBL5174021 IC50 0.0 nM
C=CC(=O)N(C)Cc1c[nH]c2ncnc(-c3cccc(NC(=O)c4ccc(C(C)(C)C)cc4)c3C)c12 CHEMBL4762397 IC50 0.014 nM
C[C@@H]1CC(=O)N2C[C@H](c3nc(-c4ccc(C(=O)Nc5cc(C(F)(F)F)ccn5)cc4)c4c(N)nccn34)CC[C@H]12 CHEMBL4113670 IC50 0.058 nM
C=CS(=O)(=O)N(C)c1cccc(-c2ccc(C(N)=O)c3[nH]c(C)c(C)c23)c1 CHEMBL4237999 IC50 0.068 nM
C#CC(=O)N[C@H]1CCCN(c2c(F)cc(C(N)=O)c3[nH]c(C)c(C)c23)C1 CHEMBL4648442 IC50 0.07 nM
Cn1cc(Nc2nccc(-c3ccc4c(c3)CN(C3COC3)CC[C@H]4NC(=O)c3cn(C(C)(C)C)nn3)n2)cn1 CHEMBL5083772 Kd 0.07 nM
Nc1nccn2c([C@@H]3CC[C@H]4CCOC(=O)N4C3)nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3)c12 CHEMBL4113445 IC50 0.075 nM
C=CS(=O)(=O)Nc1cccc(-c2ccc(C(N)=O)c3[nH]c(C)c(C)c23)c1 CHEMBL4242527 IC50 0.077 nM
C=CS(=O)(=O)Nc1cccc(-c2ccc(C(N)=O)c3[nH]c4c(c23)CCC(C(C)(C)O)C4)c1C CHEMBL4240879 IC50 0.079 nM
C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1 CHEMBL1873475 IC50 0.08 nM
Nc1nccn2c([C@@H]3CC[C@H]4C[C@H](O)C(=O)N4C3)nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3)c12 CHEMBL4109744 IC50 0.081 nM
Nc1nccn2c([C@@H]3CC[C@H]4COC(=O)N4C3)nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3F)c12 CHEMBL4109282 IC50 0.083 nM
Nc1nccn2c([C@@H]3CC[C@H]4COC(=O)N4C3)nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3)c12 CHEMBL4749037 IC50 0.083 nM
C[C@H]1CC(=O)N2C[C@H](c3nc(-c4ccc(C(=O)Nc5cc(C(F)(F)F)ccn5)cc4)c4c(N)nccn34)CC[C@@H]12 CHEMBL3938520 IC50 0.085 nM
CN1CCn2nc(Nc3nn(-c4cccc(-n5ncc6cc(C(C)(C)C)cc(F)c6c5=O)c4CO)cc3C(N)=O)cc2C1 CHEMBL3652654 IC50 0.09 nM
CC(C)(C)c1cc(F)c2c(=O)n(-c3cccc(-n4cc(C(N)=O)c(Nc5ccc(S(C)(=O)=O)cc5)n4)c3CO)ncc2c1 CHEMBL3652656 IC50 0.09 nM
C=CC(=O)N[C@@H]1CN(c2ccc(C(N)=O)c(Nc3ccc(CCN4CCCC4)cc3)n2)CC12CC2 CHEMBL4279353 IC50 0.09 nM
CN1CC[C@@H]2CC[C@@H](c3nc(-c4ccc(C(=O)Nc5cc(C(F)(F)F)ccn5)cc4)c4c(N)nccn34)CN2C1=O CHEMBL4109792 IC50 0.092 nM
Nc1nccn2c([C@H]3CC[C@@H]4CCCC(=O)N4C3)nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3F)c12 CHEMBL3924979 IC50 0.095 nM
C[C@H]1OC(=O)N2C[C@H](c3nc(-c4ccc(C(=O)Nc5cc(C(F)(F)F)ccn5)cc4F)c4c(N)nccn34)CC[C@@H]12 CHEMBL4108545 IC50 0.096 nM
Nc1nccn2c([C@@H]3CC[C@H]4CCC(=O)N4C3)nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3)c12 CHEMBL4106978 IC50 0.1 nM
Nc1nccn2c([C@H]3C[C@@H]4[C@H](C3)[C@H]4C(=O)O)nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3)c12 CHEMBL4097957 IC50 0.1 nM
Nc1nccn2c(C34C5C6C3C3C4C5C63C(=O)O)nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3F)c12 CHEMBL4079005 IC50 0.1 nM
C[C@]1(C(=O)O)CCC[C@@](C)(c2nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3)c3c(N)nccn23)C1 CHEMBL4074833 IC50 0.1 nM
CC(=O)N1CCC[C@@H](c2nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3F)c3c(N)nccn23)C1 CHEMBL4079820 IC50 0.1 nM
C=CC(=O)N1C[C@H]2C[C@@H]1CN2c1ccc(C(N)=O)c(Nc2ccc(C)nc2)n1 CHEMBL4276669 IC50 0.1 nM
CC#CC(=O)N[C@H]1CCCN(c2c(F)cc(C(N)=O)c3[nH]c(C)c(C)c23)C1 CHEMBL4297674 IC50 0.1 nM
Nc1nccn2c([C@@H]3CC[C@H]4COCC(=O)N4C3)nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3F)c12 CHEMBL4108825 IC50 0.1 nM
CC1CN(C2COC2)CCN1c1ccc(Nc2cc(-c3cccc(N4CCn5c(cc6c5CC(C)(C)C6)C4=O)c3CO)cn(C)c2=O)nc1 CHEMBL5271975 IC50 0.1 nM
Nc1nccn2c([C@@H]3CC[C@H]4CCC(=O)N4C3)nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3F)c12 CHEMBL4108563 IC50 0.11 nM
C[C@H]1OC(=O)N2C[C@H](c3nc(-c4ccc(C(=O)Nc5cc(C(F)(F)F)ccn5)cc4)c4c(N)nccn34)CC[C@@H]12 CHEMBL4110644 IC50 0.11 nM
C=CS(=O)(=O)N(C)c1cccc(-c2ccc(C(N)=O)c3[nH]c(C)c(C)c23)c1C CHEMBL4246324 IC50 0.11 nM
CC(=O)c1ccc(Nc2nn(-c3cccc(-n4ncc5cc(C(C)(C)C)ccc5c4=O)c3CO)cc2C(N)=O)cc1 CHEMBL3652680 IC50 0.12 nM
Nc1nccn2c([C@@H]3CC[C@H]4CCC(=O)N4C3)nc(-c3ccc(C(=O)Nc4cc(C(F)F)ccn4)cc3F)c12 CHEMBL4112025 IC50 0.12 nM
CC1(C)OC(=O)N2C[C@H](c3nc(-c4ccc(C(=O)Nc5cc(C(F)(F)F)ccn5)cc4)c4c(N)nccn34)CC[C@H]21 CHEMBL4108687 IC50 0.12 nM
C=CC(=O)N1CCC(c2c[nH]c3c(C(N)=O)c(-c4ccc(Oc5ccccc5)cc4)nn23)CC1 CHEMBL3925102 IC50 0.13 nM
Nc1nccn2c([C@@H]3CC[C@H]4CCC(=O)N4C3)nc(-c3ccc(C(=O)Nc4cc(OC5CC5)ccn4)cc3F)c12 CHEMBL4109294 IC50 0.13 nM
Nc1nccn2c([C@@H]3CC[C@H]4C[C@@H](O)C(=O)N4C3)nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3)c12 CHEMBL4108593 IC50 0.13 nM
Nc1nccn2c([C@@H]3CC[C@H]4CN(CCO)CC(=O)N4C3)nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3)c12 CHEMBL4108579 IC50 0.13 nM
C[C@H]1OC[C@@H]2CC[C@@H](c3nc(-c4ccc(C(=O)Nc5cc(C(F)(F)F)ccn5)cc4)c4c(N)nccn34)CN2C1=O CHEMBL4108295 IC50 0.13 nM
COc1cc(C(=O)Nc2cc(C(F)(F)F)ccn2)ccc1-c1nc([C@@H]2CC[C@H]3[C@@H](C)OC(=O)N3C2)n2ccnc(N)c12 CHEMBL4107482 IC50 0.13 nM
C=CC(=O)N1CCc2c([nH]c3c(C(N)=O)c(-c4ccc(Oc5ccccc5)cc4)nn23)C1 CHEMBL3962133 IC50 0.13 nM
C[C@@H]1OC(=O)N2C[C@H](c3nc(-c4ccc(C(=O)Nc5cc(C(F)(F)F)ccn5)cc4)c4c(N)nccn34)CC[C@@H]12 CHEMBL3942777 IC50 0.13 nM
Cn1cc(Nc2nccc(-c3ccc4c(c3)CCCCC4NC(=O)N3CC[C@@H](C(C)(C)C)C3)n2)cn1 CHEMBL5088454 IC50 0.13 nM
C=CC(=O)N1CCc2[nH]c3c(C(N)=O)c(-c4ccc(Oc5ccccc5)cc4)nn3c2C1 CHEMBL3968222 IC50 0.14 nM
CC1(C)C[C@H]2CC[C@H](c3nc(-c4ccc(C(=O)Nc5cc(C(F)(F)F)ccn5)cc4)c4c(N)nccn34)CN2C1=O CHEMBL3916919 IC50 0.14 nM
C=CS(=O)(=O)Nc1cccc(-c2ccc(C(N)=O)c3[nH]c(C)c(C)c23)c1C CHEMBL4248386 IC50 0.14 nM
C#CC(=O)N[C@H]1CCCN(c2ccc(C(N)=O)c3[nH]c(C)c(C)c23)C1 CHEMBL4634162 IC50 0.14 nM
Nc1nc(-c2cccc(-n3ccc4cc(C5CC5)cc(F)c4c3=O)c2CO)c2cc(-c3ccncc3)[nH]c2n1 CHEMBL5094211 IC50 0.14 nM
C=CC(=O)N(C)CCOc1cccc(Nc2cc(-c3cc(F)cc(-n4ncc5c6c(sc5c4=O)CCCC6)c3CO)cn(C)c2=O)n1 CHEMBL3981261 Ki 0.146 nM
C=CC(=O)N1CCCc2[nH]c3c(C(N)=O)c(-c4ccc(Oc5ccccc5)cc4)nn3c2C1 CHEMBL3922120 IC50 0.15 nM
C=CC(=O)Nc1ccccc1C1CCNc2c(C(N)=O)c(-c3cc(Cl)c(OC)c(Cl)c3)nn21 CHEMBL3954730 IC50 0.15 nM
C[C@H](O)C(=O)N1C[C@H](c2nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3F)c3c(N)nccn23)CC[C@@H]1C CHEMBL4784814 IC50 0.15 nM
COCC#CC(=O)Nc1ccc2nccc(Oc3ccc(C(=O)Nc4ccccn4)cc3)c2c1 CHEMBL4744536 IC50 0.15 nM
CCc1ccnc(NC(=O)c2ccc(-c3nc([C@@H]4CC[C@H]5CCC(=O)N5C4)n4ccnc(N)c34)cc2)c1 CHEMBL4111650 IC50 0.16 nM
CCOc1cc(C(=O)Nc2cc(C(F)(F)F)ccn2)ccc1-c1nc([C@@H]2CC[C@H]3CCC(=O)N3C2)n2ccnc(N)c12 CHEMBL4110388 IC50 0.16 nM
Nc1ncc(Cl)n2c([C@@H]3CC[C@H]4CCC(=O)N4C3)nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3)c12 CHEMBL4106573 IC50 0.16 nM
C=CC(=O)N(C)c1cccc(-c2ccc(C(N)=O)c3[nH]c4cc(C(C)(C)O)ccc4c23)c1 CHEMBL4248271 IC50 0.16 nM
CC(C)(C)c1cc(F)c2c(=O)n(-c3cccc(-n4cc(C(N)=O)c(Nc5ccc(S(C)(=O)=O)cn5)n4)c3CO)ncc2c1 CHEMBL3652667 IC50 0.17 nM
CN(C)C/C=C/C(=O)N1CCc2c([nH]c3c(C(N)=O)c(-c4ccc(Oc5ccccc5)cc4)nn23)C1 CHEMBL3905984 IC50 0.17 nM
C[C@@H]1OC(=O)N2C[C@H](c3nc(-c4ccc(C(=O)Nc5cc(C(F)(F)F)ccn5)cc4F)c4c(N)nccn34)CC[C@@H]12 CHEMBL3922148 IC50 0.17 nM
C[C@H]1OC(=O)N2C[C@H](c3nc(-c4ccc(C(=O)Nc5cc(C6CC6)ccn5)cc4)c4c(N)nccn34)CC[C@@H]12 CHEMBL4110653 IC50 0.17 nM
COc1cc(C(=O)Nc2cc(C(F)(F)F)ccn2)cc(F)c1-c1nc([C@@H]2CC[C@H]3CCC(=O)N3C2)n2c(Cl)cnc(N)c12 CHEMBL4111363 IC50 0.17 nM
C=CC(=O)Nc1cccc(-c2ccc(C(N)=O)c3[nH]c4c(c23)CCC(C(C)(C)O)C4)c1 CHEMBL4248719 IC50 0.17 nM
C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c(C(N)=O)c2N)C1 CHEMBL4447328 IC50 0.17 nM
CC(=O)N1C[C@H](c2nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3F)c3c(N)nccn23)CC[C@@H]1C CHEMBL4752314 IC50 0.17 nM
C[C@H]1CC[C@@H](c2nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3F)c3c(N)nccn23)CN1C(=O)C1(C)COC1 CHEMBL4744759 IC50 0.17 nM
CC(C)(CN1CCC1)Oc1ccc(Nc2nn(-c3cccc(-n4ncc5cc(C(C)(C)C)cc(F)c5c4=O)c3CO)cc2C(N)=O)nc1 CHEMBL3652653 IC50 0.18 nM
CC(C)(C)c1cc(F)c2c(=O)n(-c3cccc(-n4cc(C(N)=O)c(Nc5ccc(C#N)cn5)n4)c3CO)ncc2c1 CHEMBL3652668 IC50 0.18 nM
Cn1c(=O)n(-c2cccc(-c3c(F)cc(C(N)=O)c4[nH]c5cc(C(C)(C)O)ccc5c34)c2Cl)c(=O)c2cccc(F)c21 CHEMBL3912426 IC50 0.18 nM
Nc1nccn2c([C@@H]3CC[C@H]4CCC(=O)N4C3)nc(-c3ccc(C(=O)Nc4cc(C5CC5)ccn4)cc3)c12 CHEMBL4113354 IC50 0.18 nM
COc1cc(C(=O)Nc2cc(C(F)(F)F)ccn2)ccc1-c1nc([C@@H]2CC[C@@H]3N(C2)C(=O)OC3(C)C)n2ccnc(N)c12 CHEMBL4113263 IC50 0.18 nM
C=CS(=O)(=O)N(C)c1cccc(-c2ccc(C(N)=O)c3[nH]c4c(c23)CCC(C(C)(C)O)C4)c1 CHEMBL4248550 IC50 0.18 nM
C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccc(Cl)cc4)cc3)c(C(N)=O)c2N)C1 CHEMBL4520801 IC50 0.18 nM
Cc1c(-c2c(F)cc(C(N)=O)c3[nH]c4cc(C(C)(C)O)ccc4c23)cccc1-n1c(=O)cc2c(Cl)cccn2c1=O CHEMBL3891545 IC50 0.19 nM
CN(C)C/C=C/C(=O)N1CCc2[nH]c3c(C(N)=O)c(-c4ccc(Oc5ccccc5)cc4)nn3c2C1 CHEMBL3973566 IC50 0.19 nM
COC(=O)CN1CC(=O)N2C[C@H](c3nc(-c4ccc(C(=O)Nc5cc(C(F)(F)F)ccn5)cc4)c4c(N)nccn34)CC[C@H]2C1 CHEMBL4109144 IC50 0.19 nM
COc1cc(C(=O)Nc2cc(C(F)(F)F)ccn2)ccc1-c1nc([C@@H]2CC[C@H]3CCC(=O)N3C2)n2ccnc(N)c12 CHEMBL4114929 IC50 0.19 nM
Nc1nccn2c([C@@H]3CC[C@H]4CCC(=O)N4C3)nc(-c3ccc(C(=O)Nc4cc5ccccc5cn4)cc3)c12 CHEMBL4107467 IC50 0.19 nM
C[C@@H](O)C(=O)N1C[C@H](c2nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3F)c3c(N)nccn23)CC[C@@H]1C CHEMBL4798236 IC50 0.19 nM
Cc1c(-c2c(F)cc(C(N)=O)c3[nH]c4cc(C(C)(C)O)ccc4c23)cccc1-n1c(=O)cc2c(F)cccn2c1=O CHEMBL3923822 IC50 0.2 nM
Nc1nccn2c([C@@H]3CC[C@H]4CCC(=O)N4C3)nc(-c3ccc(C(=O)Nc4cc(C5CC5)ccn4)cc3F)c12 CHEMBL4112223 IC50 0.2 nM
CCOc1cc(C(=O)Nc2cc(C(F)(F)F)ccn2)ccc1-c1nc([C@@H]2CC[C@@H]3N(C2)C(=O)CC3(C)C)n2ccnc(N)c12 CHEMBL4114097 IC50 0.2 nM
NC(=O)[C@H]1CCC[C@@H](c2nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3)c3c(N)nccn23)C1 CHEMBL4070865 IC50 0.2 nM
Nc1nccn2c(C34CCC(C(=O)O)(CC3)CC4)nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3)c12 CHEMBL4059473 IC50 0.2 nM
Nc1nccn2c1c(-c1ccc(C(=O)Nc3cc(C(F)(F)F)ccn3)cc1)nc2[C@]12CC[C@](C(=O)O)(CC1)C2 CHEMBL4068131 IC50 0.2 nM
C[C@]1(C(=O)O)CC[C@@](C)(c2nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3)c3c(N)nccn23)C1 CHEMBL4068919 IC50 0.2 nM
COCC(=O)N1CCC[C@@H](c2nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3F)c3c(N)nccn23)C1 CHEMBL4076024 IC50 0.2 nM
Nc1cc(-c2cccc(-n3ccc4cc(C5CC5)cc(F)c4c3=O)c2CO)nc(Nc2cnn(CC(F)F)c2)n1 CHEMBL4211960 IC50 0.2 nM
CC(C)n1cc(Nc2nc(N)cc(-c3cccc(-n4ccc5cc(C6CC6)cc(F)c5c4=O)c3CO)n2)cn1 CHEMBL4212285 IC50 0.2 nM
C#CC(=O)N1CCC(CNc2ncnc(N)c2-c2ccc(Oc3ccccc3)cc2)CC1 CHEMBL4543998 IC50 0.2 nM
C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3ccccc32)C1 CHEMBL4466205 IC50 0.2 nM
Cc1cc(-c2ccnc(Nc3cnn(C)c3)n2)ccc1CNC(=O)c1cnc(C(C)(C)C)s1 CHEMBL4754065 IC50 0.2 nM
Cc1cc(-c2ccnc(Nc3cnn(C)c3)n2)ccc1CNC(=O)N1CCC(C(C)(C)C)C1 CHEMBL4782313 IC50 0.2 nM
Cn1cc(Nc2nccc(-c3ccc4c(c3)CCCCC4NC(=O)c3cn(C(C)(C)C)nn3)n2)cn1 CHEMBL5087011 IC50 0.2 nM
COc1cc(C(=O)Nc2cc(C(F)(F)F)ccn2)ccc1-c1nc([C@@H]2CC[C@H]3CN(C(=O)c4ccncc4)CC(=O)N3C2)n2ccnc(N)c12 CHEMBL4111143 IC50 0.2 nM
Nc1nccn2c([C@@H]3CC[C@H]4CN(C(=O)c5ccccc5)CC(=O)N4C3)nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3)c12 CHEMBL4109377 IC50 0.2 nM
N#Cc1ccnc(NC(=O)c2ccc(-c3nc([C@@H]4CC[C@H]5CCC(=O)N5C4)n4ccnc(N)c34)c(F)c2)c1 CHEMBL4109557 IC50 0.21 nM
CC(F)(F)c1ccnc(NC(=O)c2ccc(-c3nc([C@@H]4CC[C@H]5CCC(=O)N5C4)n4ccnc(N)c34)c(F)c2)c1 CHEMBL4112201 IC50 0.21 nM
C[C@H]1OC(=O)N2C[C@H](c3nc(-c4ccc(C(=O)Nc5cc(C6CC6)ccn5)cc4F)c4c(N)nccn34)CC[C@@H]12 CHEMBL4111521 IC50 0.21 nM
Nc1nccn2c([C@@H]3CC[C@H]4CN(C(=O)c5ccncc5)CC(=O)N4C3)nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3)c12 CHEMBL4112274 IC50 0.21 nM
C=CC(=O)Nc1cccc(-c2ccc(C(N)=O)c3[nH]c(C)c(C)c23)c1 CHEMBL4243995 IC50 0.21 nM
C=CC(=O)Nc1cccc(-c2ccc(C(N)=O)c3[nH]c4c(c23)CCC(C(C)(C)O)C4)c1C CHEMBL4241958 IC50 0.21 nM
Cn1ccc(Nc2nn(-c3cccc(-n4ncc5cc(C(C)(C)C)cc(F)c5c4=O)c3CO)cc2C(N)=O)n1 CHEMBL3652657 IC50 0.22 nM
Nc1nccn2c([C@@H]3CC[C@H]4CNCC(=O)N4C3)nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3)c12 CHEMBL4111645 IC50 0.22 nM
Nc1nccn2c([C@@H]3CC[C@H]4CN(CC(=O)O)CC(=O)N4C3)nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3)c12 CHEMBL4111121 IC50 0.22 nM
COc1cc(C(=O)Nc2cc(C(F)(F)F)ccn2)ccc1-c1nc([C@@H]2CC[C@H]3CCC(=O)N3C2)n2c(Cl)cnc(N)c12 CHEMBL4107715 IC50 0.22 nM
C[C@H]1CC[C@@H](c2nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3F)c3c(N)nccn23)CN1C(=O)C1CCCO1 CHEMBL4751655 IC50 0.22 nM
C=CC(=O)N(C)CCOc1c(N)ncnc1-c1ccc(CN2CCN(CC(C)C)CC2=O)c(C)c1 CHEMBL5188786 IC50 0.22 nM
C=CC(=O)Nc1ccccc1[C@H]1CCNc2c(C(N)=O)c(-c3ccc(C)c(OC)c3)nn21 CHEMBL4111890 IC50 0.23 nM
CCOc1cc(C(=O)Nc2cc(C(F)(F)F)n(C)n2)ccc1-c1nc([C@@H]2CC[C@H]3CCC(=O)N3C2)n2c(Cl)cnc(N)c12 CHEMBL4110406 IC50 0.23 nM
C=CC(=O)Nc1cccc(Nc2nc(Nc3ccc(OCC(=O)OCC4CCCO4)cc3)ncc2Cl)c1 CHEMBL4060363 IC50 0.23 nM
C=CC(=O)N(C)c1cccc(-c2ccc(C(N)=O)c3[nH]c(C)c(C)c23)c1 CHEMBL4247992 IC50 0.23 nM
CC(C)n1cc(-c2nc3c(-c4ccc5c(c4)CCC[C@@H]5NC(=O)c4nc(C(C)(C)C)no4)ccnc3[nH]2)cn1 CHEMBL4868813 IC50 0.23 nM
CC(C)(C)c1cc(F)c2c(=O)n(-c3cccc(-n4cc(C(N)=O)c(Nc5ccc(F)cn5)n4)c3CO)ncc2c1 CHEMBL3652659 IC50 0.24 nM
Cc1ccc(Nc2nn(-c3cccc(-n4ncc5cc(C(C)(C)C)cc(F)c5c4=O)c3CO)cc2C(N)=O)nc1 CHEMBL3652662 IC50 0.24 nM
Nc1nccn2c([C@@H]3CC[C@H]4CCC(=O)N4C3)nc(-c3ccc(C(=O)Nc4cc(OC5CC5)ccn4)cc3)c12 CHEMBL4112085 IC50 0.24 nM
C=CC(=O)N(C)c1cccc(-c2ccc(C(N)=O)c3[nH]c4c(c23)CCC(C(C)(C)O)C4)c1 CHEMBL4237249 IC50 0.24 nM
C=CC(=O)NCC1CCNc2c(C(N)=O)c(-c3ccc(Oc4ccccc4)cc3)nn21 CHEMBL3977729 IC50 0.24 nM
C[C@@H]1CN(C2COC2)CCN1c1ccc(Nc2cc(-c3ccnc(N4CCn5c(cc6c5CC(C)(C)C6)C4=O)c3CO)cn(C)c2=O)nc1 CHEMBL4066176 Kd 0.24 nM
C=CC(=O)N(C)CCOc1c(N)ncnc1-c1cc(F)cc(NC(=O)c2ccc(C3CC3)cc2F)c1C CHEMBL4483575 Kd 0.24 nM
C=CC(=O)NCCNc1cccc(Nc2cc(-c3cc(F)cc(-n4ncc5c6c(sc5c4=O)CCCC6)c3CO)cn(C)c2=O)n1 CHEMBL3899326 Ki 0.248 nM
COC(C)(C)CCn1nc(Nc2c(C)cccc2C)c2cnc(Nc3ccc(OCCN4CCCC4)cc3)nc21 CHEMBL458333 Ki 0.25 nM
Cc1c(-c2c(Cl)cc(C(N)=O)c3[nH]c4cc(C(C)(C)O)ccc4c23)cccc1-n1c(=O)cc2c(F)cccn2c1=O CHEMBL3944101 IC50 0.25 nM
Cc1c(-c2c(Cl)cc(C(N)=O)c3[nH]c4c(c23)CC[C@H](C(C)(C)O)C4)cccc1-n1c(=O)[nH]c2c(F)cc(F)cc2c1=O CHEMBL3910427 IC50 0.25 nM
CC(C)C(=O)N1CCC[C@@H](c2nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3F)c3c(N)nccn23)C1 CHEMBL4069387 IC50 0.25 nM
C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccc(F)cc4F)cc3)c(C(N)=O)c2N)C1 CHEMBL4442732 IC50 0.25 nM
Cc1c(-c2c(Cl)cc(C(N)=O)c3[nH]c4cc(C(C)(C)O)ccc4c23)cccc1-n1c(=O)cc2c(Cl)cccn2c1=O CHEMBL3928976 IC50 0.26 nM
Cc1c(-c2c(Cl)cc(C(N)=O)c3[nH]c4c(c23)CC[C@H](C(C)(C)O)C4)cccc1-n1c(=O)[nH]c2c(F)cccc2c1=O CHEMBL3945408 IC50 0.26 nM
Cc1c(-c2c(F)cc(C(N)=O)c3[nH]c4cc(C(C)(C)O)ccc4c23)cccc1-n1c(=O)[nH]c2c(F)cc(F)cc2c1=O CHEMBL3894000 IC50 0.26 nM
CN1CC(=O)N2C[C@H](c3nc(-c4ccc(C(=O)Nc5cc(C(F)(F)F)ccn5)cc4)c4c(N)nccn34)CC[C@H]2C1 CHEMBL4113994 IC50 0.26 nM
Nc1nccn2c([C@H]3CN4C(=O)CC[C@@H]4CO3)nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3)c12 CHEMBL4114094 IC50 0.26 nM
O=C(C#CCN1CCOCC1)Nc1ccc2nccc(Oc3ccc(C(=O)Nc4ccccn4)cc3)c2c1 CHEMBL4763873 IC50 0.26 nM
CN1CC(=O)N2C[C@H](c3nc(-c4ccc(C(=O)Nc5cc(C(F)(F)F)ccn5)cc4F)c4c(N)nccn34)CC[C@H]2C1 CHEMBL4757041 IC50 0.26 nM
Cc1c(-c2c(C#N)cc(C(N)=O)c3[nH]c4cc(C(C)(C)O)ccc4c23)cccc1-n1c(=O)c2cccc(F)c2n(C)c1=O CHEMBL3899411 IC50 0.27 nM
CCN1CC(=O)N2C[C@H](c3nc(-c4ccc(C(=O)Nc5cc(C(F)(F)F)ccn5)cc4)c4c(N)nccn34)CC[C@H]2C1 CHEMBL4111825 IC50 0.27 nM
CCOc1cc(C(=O)Nc2cc(C(F)(F)F)ccn2)ccc1-c1nc([C@@H]2CC[C@H]3CCC(=O)N3C2)n2c(Cl)cnc(N)c12 CHEMBL4109533 IC50 0.27 nM
CC1(C(=O)N2CCC[C@@H](c3nc(-c4ccc(C(=O)Nc5cc(C(F)(F)F)ccn5)cc4)c4c(N)nccn34)C2)COC1 CHEMBL4094125 IC50 0.27 nM
Nc1nccn2c([C@H]3CC[C@H]4CNCC(=O)N4C3)nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3)c12 CHEMBL3901061 IC50 0.28 nM
COc1cc(C(=O)Nc2cc(C(F)(F)F)ccn2)cc(F)c1-c1nc([C@@H]2CC[C@H]3CCC(=O)N3C2)n2ccnc(N)c12 CHEMBL4114985 IC50 0.28 nM
Nc1ncc(F)n2c([C@@H]3CC[C@H]4CCC(=O)N4C3)nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3)c12 CHEMBL4112426 IC50 0.28 nM
COc1cc(C(=O)Nc2cc(C(F)(F)F)ccn2)cc(F)c1-c1nc([C@@H]2CC[C@H]3CC(C)(C)C(=O)N3C2)n2ccnc(N)c12 CHEMBL4111662 IC50 0.28 nM
CCC(=O)N1C[C@H](c2nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3F)c3c(N)nccn23)CC[C@@H]1C CHEMBL4798188 IC50 0.28 nM
CC(C)(C)c1cc(F)c2c(=O)n(-c3cccc(-n4cc(C(N)=O)c(Nc5ccc(Cl)cn5)n4)c3CO)ncc2c1 CHEMBL3652652 IC50 0.29 nM
Cc1cc(Nc2nn(-c3cccc(-n4ncc5cc(C(C)(C)C)cc(F)c5c4=O)c3CO)cc2C(N)=O)nn1C CHEMBL3652660 IC50 0.29 nM
CC(C)N1CC(=O)N2C[C@H](c3nc(-c4ccc(C(=O)Nc5cc(C(F)(F)F)ccn5)cc4)c4c(N)nccn34)CC[C@H]2C1 CHEMBL4112832 IC50 0.29 nM
CN1CCN(c2ccc(Nc3cc(-c4cccc(-n5ccc6cc(C7CC7)cc(F)c6c5=O)c4CO)cn(C)c3=O)nc2)CC1 CHEMBL2057918 IC50 0.3 nM
[C-]#[N+]/C(=C/C(C)(C)N1CCN(C)CC1)C(=O)N1CCC[C@H](n2nc(-c3ccc(Oc4ccccc4)cc3F)c3c(N)ncnc32)C1 CHEMBL3952977 IC50 0.3 nM
[C-]#[N+]/C(=C\C(C)(C)N1CCN(C)CC1)C(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3F)c3c(N)ncnc32)C1 CHEMBL3702830 IC50 0.3 nM
Cc1c(-c2c(F)cc(C(N)=O)c3[nH]c4cc(C(C)(C)O)ccc4c23)cccc1-n1c(=O)[nH]c2cc(F)ccc2c1=O CHEMBL3945518 IC50 0.3 nM
Nc1nccn2c([C@@H]3CC[C@H]4COCCN4C3)nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3)c12 CHEMBL4110169 IC50 0.3 nM
Nc1nccn2c([C@@H]3CCC[C@H](c4nnc[nH]4)C3)nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3)c12 CHEMBL4100424 IC50 0.3 nM
Cn1nnnc1[C@H]1CCC[C@@H](c2nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3)c3c(N)nccn23)C1 CHEMBL4081452 IC50 0.3 nM
Nc1nccn2c1c(-c1ccc(C(=O)Nc3cc(C(F)(F)F)ccn3)cc1)nc2[C@]12CCC[C@](C(=O)O)(CC1)CC2 CHEMBL4081444 IC50 0.3 nM
CCOc1cc(C(=O)Nc2cc(C(F)(F)F)ccn2)ccc1-c1nc(C23CCC(C(=O)O)(CC2)CC3)n2ccnc(N)c12 CHEMBL4097019 IC50 0.3 nM
C[C@H]1CC[C@@H](c2nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3F)c3c(N)nccn23)CN1C(=O)C1CC1 CHEMBL4103954 IC50 0.3 nM
CC1(C(=O)N2CCC[C@@H](c3nc(-c4ccc(C(=O)Nc5cc(C(F)(F)F)ccn5)cc4F)c4c(N)nccn34)C2)CCC1 CHEMBL4081661 IC50 0.3 nM
Nc1cc(-c2cccc(-n3ccc4cc(C5CC5)cc(F)c4c3=O)c2CO)nc(Nc2cnn(CC3CC3)c2)n1 CHEMBL4215160 IC50 0.3 nM
Nc1cc(-c2cccc(-n3ccc4cc(C5CC5)cc(F)c4c3=O)c2CO)nc(Nc2cnn(C3CC3)c2)n1 CHEMBL4213985 IC50 0.3 nM
C=CC(=O)N1CCN(c2ccc(C(N)=O)c(Nc3ccc(CCN4CCCC4)cc3)n2)CC1 CHEMBL4279430 IC50 0.3 nM
C=CC(=O)N1CCC([C@@H]2CCNc3c(C(N)=O)c(-c4ccc(Oc5ccccc5)cc4)nn32)CC1 CHEMBL3936761 IC50 0.3 nM
Cc1cc(-c2ccnc(Nc3cnn(C)c3)n2)ccc1CNC(=O)N1CC(OC(C)C)C1 CHEMBL4744041 Kd 0.3 nM
CC(C)(C)c1noc(C(=O)NCc2ccc(-c3ccnc4[nH]c(-c5cnn(CCN6CCOCC6)c5)nc34)cc2F)n1 CHEMBL4878102 IC50 0.3 nM
Cn1cc(Nc2nccc(-c3ccc4c(c3)CCCCC4NC(=O)c3cnc(C(C)(C)C)s3)n2)cn1 CHEMBL5089878 IC50 0.3 nM
Cn1cc(Nc2nccc(-c3ccc4c(c3)CCCCC4NC(=O)c3noc(C(C)(C)C)n3)n2)cn1 CHEMBL5083323 IC50 0.3 nM
Cn1cc(Nc2nccc(-c3ccc4c(c3)CCCCC4NC(=O)c3nc(C(C)(C)C)no3)n2)cn1 CHEMBL5084997 IC50 0.3 nM
CN1CCN(C(C)(C)/C=C(\C#N)C(=O)N2CCC[C@@H](n3nc(-c4ccc(Oc5ccccc5)cc4F)c4c(N)ncnc43)C2)CC1 CHEMBL5189379 IC50 0.3 nM
Cc1cc(C(N)=O)c2[nH]c3cc(C(C)(C)O)ccc3c2c1-c1cccc(-n2c(=O)[nH]c3c(F)cccc3c2=O)c1O CHEMBL5200336 IC50 0.3 nM
C=CC(=O)N1CCC(C2CCNc3c(C(N)=O)c(-c4ccc(Oc5ccccc5)cc4)nn32)CC1 CHEMBL3973435 IC50 0.3 nM
CC#CC(=O)NCCOc1cccc(Nc2cc(-c3cc(F)cc(-n4ncc5c6c(sc5c4=O)CCCC6)c3CO)cn(C)c2=O)n1 CHEMBL3967132 Ki 0.306 nM
Cc1c(-c2c(Cl)cc(C(N)=O)c3[nH]c4cc(C(C)(C)O)ccc4c23)cccc1-n1c(=O)cc2sccn2c1=O CHEMBL3917869 IC50 0.31 nM
Nc1nccn2c([C@@H]3CC[C@H]4CCC(=O)N4C3)nc(-c3ccc(C(=O)Nc4cc(C(F)F)ccn4)cc3)c12 CHEMBL4112027 IC50 0.31 nM
COC[C@H]1CC[C@@H](c2nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3)c3c(N)nccn23)CN1C(=O)C1(C)COC1 CHEMBL4746292 IC50 0.31 nM
C=CC(=O)NCCn1nc(-c2ccc(Oc3ccccc3)cc2)c2c(N)ncnc21 CHEMBL3894938 IC50 0.32 nM
C=CC(=O)Nc1ccc2[nH]c3c(C(N)=O)c(-c4ccc(Oc5ccccc5)cc4)nn3c2c1 CHEMBL3948065 IC50 0.32 nM
C[C@H]1CN(c2ccc(Nc3cc(-c4cc(F)cc(N5CCn6c(cc7c6CCCC7)C5=O)c4CO)cn(C)c3=O)nc2)CCN1C CHEMBL4102992 Ki 0.32 nM
C=CC(=O)Nc1cccc(-c2ccc(C(N)=O)c3[nH]c(C)cc23)c1C CHEMBL4238798 IC50 0.32 nM
C[C@H]1CC[C@@H](c2nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3F)c3c(N)nccn23)CN1C(=O)C(C)(C)O CHEMBL4756290 IC50 0.32 nM
CC1(C(=O)N2CCC[C@@H](c3nc(-c4ccc(C(=O)Nc5cc(C(F)(F)F)ccn5)cc4F)c4c(N)nccn34)C2)COC1 CHEMBL4799627 IC50 0.32 nM
Cc1c(-c2c(F)cc(C(N)=O)c3[nH]c4cc(C(C)(C)O)ccc4c23)cccc1-n1c(=O)[nH]c2c(F)cccc2c1=O CHEMBL3907348 IC50 0.33 nM
Cc1c(-c2c(Cl)cc(C(N)=O)c3[nH]c4cc(C(C)(C)O)ccc4c23)cccc1-n1c(=O)ccn(-c2ccc(F)cc2)c1=O CHEMBL3913962 IC50 0.33 nM
Cc1c(-c2c(Cl)cc(C(N)=O)c3[nH]c4cc(C(C)(C)O)ccc4c23)cccc1-n1c(=O)[nH]c2c(F)cc(F)cc2c1=O CHEMBL3943055 IC50 0.33 nM
Cn1ncc2c1CCC[C@@]2(O)c1nc(-c2ccc(C(=O)Nc3cc(C(F)(F)F)ccn3)cc2)c2c(N)nccn12 CHEMBL3916236 IC50 0.33 nM
C=CC(=O)N1CCC([C@H]2CCNc3c(C(N)=O)c(-c4ccc(Oc5ccccc5)cc4)nn32)CC1 CHEMBL4107402 IC50 0.33 nM
C=CC(=O)N1CC[C@]2(C1)C[C@H](n1c(NC(=O)c3ccc(-c4cc[nH]c(=O)c4)s3)nc3ccccc31)C2 CHEMBL4206765 IC50 0.33 nM
O=C(C#CCO)Nc1ccc2nccc(Oc3ccc(C(=O)Nc4ccccn4)cc3)c2c1 CHEMBL4791702 IC50 0.33 nM
C=CC(=O)Nc1ccccc1C1CCNc2c(C(N)=O)c(-c3cc(OC)c(C)c(OC)c3)nn21 CHEMBL5282956 IC50 0.33 nM
Cc1c(-c2c(F)cc(C(N)=O)c3[nH]c4c(c23)CC[C@H](C(C)(C)O)C4)cccc1-n1c(=O)cc2c(Cl)cccn2c1=O CHEMBL3984475 IC50 0.34 nM
Cc1cc(C(N)=O)c2[nH]c3cc(C(C)(C)O)ccc3c2c1-c1cccc(-n2c(=O)[nH]c3c(F)cccc3c2=O)c1Cl CHEMBL3987197 IC50 0.34 nM
Nc1ncc(F)n2c([C@@H]3CC[C@H]4CCC(=O)N4C3)nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3F)c12 CHEMBL4106893 IC50 0.34 nM
CC(C)(O)c1ccc2c(c1)[nH]c1c(C(N)=O)cc(Cl)c(-c3cccc(-n4c(=O)[nH]c5c(F)cccc5c4=O)c3Cl)c12 CHEMBL3960384 IC50 0.35 nM
Cc1c(-c2c(F)cc(C(N)=O)c3[nH]c4cc(C(C)(C)O)ccc4c23)cccc1-n1c(=O)[nH]c2c(Cl)cccc2c1=O CHEMBL3908440 IC50 0.35 nM
CN1CCN(c2ccc(Nc3cc(-c4cc(F)cc(N5CCn6c(cc7c6CCCC7)C5=O)c4CO)cn(C)c3=O)nc2)CC1 CHEMBL3670094 Ki 0.35 nM
C[C@H]1CN(C2COC2)CCN1c1ccc(Nc2cc(-c3ccnc(N4CCn5c(cc6c5CC(C)(C)C6)C4=O)c3CO)cn(C)c2=O)nc1 CHEMBL4065122 Kd 0.35 nM
CC(C)(C)c1cc(F)c2c(=O)n(-c3cccc(-n4cc(C(N)=O)c(Nc5ccccn5)n4)c3CO)ncc2c1 CHEMBL3652655 IC50 0.36 nM
C=CC(=O)N1CCc2[nH]c3c(C(N)=O)c(-c4ccc(Oc5ccccc5)cc4)nn3c2CC1 CHEMBL3913116 IC50 0.36 nM
COCCC(=O)N1C[C@H](c2nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3F)c3c(N)nccn23)CC[C@@H]1C CHEMBL4761778 IC50 0.36 nM
C[C@@H]1CN(C)CCN1c1ccc(Nc2cc(-c3cc(F)cc(N4CCn5c(cc6c5CCCC6)C4=O)c3CO)cn(C)c2=O)nc1 CHEMBL4095379 Ki 0.37 nM
COCC(=O)N1CCO[C@@H](c2nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3F)c3c(N)nccn23)C1 CHEMBL4062498 IC50 0.37 nM
N#CN1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c(C(N)=O)c2N)C1 CHEMBL4436118 IC50 0.37 nM
CC1(C(=O)N2CCC[C@@H](c3nc(-c4ccc(C(=O)Nc5cc(C#N)ccn5)cc4F)c4c(N)nccn34)C2)COC1 CHEMBL4744308 IC50 0.37 nM
C=CC(=O)N1CC(C2CCNc3c(C(N)=O)c(-c4ccc(Oc5ccccc5C#N)cc4)nn32)C1 CHEMBL3972744 IC50 0.38 nM
C=CC(=O)Nc1ccccc1C1CCNc2c(C(N)=O)c(-c3ccc(F)c(C)c3)nn21 CHEMBL3960617 IC50 0.38 nM
C=CC(=O)Nc1cccc(-c2ccc(C(N)=O)c3[nH]c(C)c(C)c23)c1C CHEMBL4237557 IC50 0.38 nM
C=CC(=O)Nc1ccccc1C1CCNc2c(C(N)=O)c(-c3ccc(Oc4ccccc4)cc3)nn21 CHEMBL3917732 IC50 0.38 nM
CN(C)Cc1ccc(Nc2nn(-c3cccc(-n4ncc5cc(C(C)(C)C)ccc5c4=O)c3CO)cc2C(N)=O)nc1 CHEMBL3652682 IC50 0.39 nM
C=CC(=O)N1CCC[C@H]1Cn1nc(-c2ccc(Oc3ccccc3)cc2)c2c(N)ncnc21 CHEMBL3910496 IC50 0.39 nM
C[C@@H]1OC(=O)N2C[C@H](c3nc(-c4ccc(C(=O)Nc5cc(C6CC6)ccn5)cc4F)c4c(N)nccn34)CC[C@@H]12 CHEMBL3903010 IC50 0.39 nM
Nc1ncc(Cl)n2c([C@@H]3CC[C@H]4CCC(=O)N4C3)nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3Cl)c12 CHEMBL4114207 IC50 0.39 nM
Cn1cc(Nc2nc(N)nc(-c3cccc(-n4ccc5cc(C6CC6)cc(F)c5c4=O)c3CO)n2)cn1 CHEMBL4209441 IC50 0.39 nM
Cn1cc(Nc2nc(N)nc(-c3cccc(-n4ccc5cc(C6CC6)cc(F)c5c4=O)c3CO)n2)cc1C#N CHEMBL4204675 IC50 0.39 nM
O=C(c1ccc(Oc2ccccc2)cc1Cl)c1c[nH]c2ncnc(N[C@@H]3CC[C@@H](CO)OC3)c12 CHEMBL4756476 IC50 0.39 nM
O=C(c1ccc(Oc2ccccc2)cc1Cl)c1c[nH]c2ncnc(N[C@H]3CC[C@H](CO)OC3)c12 CHEMBL5071372 IC50 0.39 nM
O=C(c1ccc(Oc2ccccc2)cc1Cl)c1c[nH]c2ncnc(N[C@H]3CCC[C@H](CO)O3)c12 CHEMBL5171706 IC50 0.39 nM
O=C(c1ccc(Oc2ccccc2)cc1Cl)c1c[nH]c2ncnc(NC3CC[C@@H](CO)OC3)c12 CHEMBL5280844 IC50 0.39 nM
CCN(CC)C/C=C/c1nc(O)c2c(ccc3nc(Nc4c(Cl)cccc4Cl)n(C)c32)c1C CHEMBL281957 IC50 0.4 nM
C=CC(=O)Nc1cccc(-n2cnc3cnc(Nc4ccc(OCCCN5CCOCC5)cc4)nc32)c1 CHEMBL3893465 IC50 0.4 nM
[C-]#[N+]/C(=C/C(C)(C)N1CCNCC1)C(=O)N1CCC[C@H](n2nc(-c3ccc(Oc4ccccc4)cc3F)c3c(N)ncnc32)C1 CHEMBL3985927 IC50 0.4 nM
CN(C)C(C)(C)/C=C(\C#N)C(=O)N1CCC[C@H]1Cn1nc(-c2ccc(Oc3ccccc3)cc2F)c2c(N)ncnc21 CHEMBL3902317 IC50 0.4 nM
CCNC(C)(C)/C=C(\C#N)C(=O)N1CCC[C@@H]1Cn1nc(-c2ccc(Oc3ccccc3)cc2F)c2c(N)ncnc21 CHEMBL4114726 IC50 0.4 nM
[C-]#[N+]/C(=C\C(C)(C)N1CCNCC1)C(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3F)c3c(N)ncnc32)C1 CHEMBL3702832 IC50 0.4 nM
Cc1c(-c2c(Cl)cc(C(N)=O)c3[nH]c4cc(C(C)(C)O)ccc4c23)cccc1-n1c(=O)c2cccc(F)c2n(C)c1=O CHEMBL3936249 IC50 0.4 nM
C=CC(=O)Nc1ccccc1[C@H]1CCNc2c(C(N)=O)c(-c3ccc(Oc4ccccc4)cc3)nn21 CHEMBL4112596 IC50 0.4 nM
COC(=O)c1ccnc(NC(=O)c2ccc(-c3nc([C@@H]4CC[C@H]5CCC(=O)N5C4)n4ccnc(N)c34)cc2)c1 CHEMBL4111935 IC50 0.4 nM
COc1cc(C(=O)Nc2cc(C(F)(F)F)ccn2)cc(F)c1-c1nc([C@@H]2CC[C@H]3CCC(=O)N3C2)n2c(F)cnc(N)c12 CHEMBL4110390 IC50 0.4 nM
Nc1nccn2c([C@@H]3CCC[C@H](C(=O)O)C3)nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3)c12 CHEMBL4087679 IC50 0.4 nM
CC(C)[C@H]1CC[C@@H](c2nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3)c3c(N)nccn23)C[C@H]1C(=O)O CHEMBL4070853 IC50 0.4 nM
Nc1nccn2c(C34CC(C(=O)O)(C3)C4)nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3)c12 CHEMBL4089318 IC50 0.4 nM
CC(C)[C@@]1(C(=O)O)CC[C@@](C)(c2nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3)c3c(N)nccn23)C1 CHEMBL4096195 IC50 0.4 nM
C[C@H]1CO[C@@H](c2nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3F)c3c(N)nccn23)CN1C(=O)C1CC1 CHEMBL4096669 IC50 0.4 nM
CC(C)C(=O)N1CCO[C@@H](c2nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3F)c3c(N)nccn23)C1 CHEMBL4075954 IC50 0.4 nM
CC(=O)N1CCO[C@@H](c2nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3F)c3c(N)nccn23)C1 CHEMBL4065907 IC50 0.4 nM
CCn1cc(Nc2nc(N)cc(-c3cccc(-n4ccc5cc(C6CC6)cc(F)c5c4=O)c3CO)n2)cn1 CHEMBL4204719 IC50 0.4 nM
Cn1cc(Nc2nc(N)cc(-c3cccc(-n4ccc5cc(C6CC6)cc(F)c5c4=O)c3CO)n2)cn1 CHEMBL4216609 IC50 0.4 nM
CN1CCN(c2ccc(Nc3nc(N)cc(-c4cccc(-n5ccc6cc(C7CC7)cc(F)c6c5=O)c4CO)n3)cc2)CC1 CHEMBL4218643 IC50 0.4 nM
C=C1c2c(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc3n2C[C@H]1NC(=O)C#CC CHEMBL4214532 IC50 0.4 nM
C=CC(=O)N[C@@H]1Cn2c(c(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1=C CHEMBL4211949 IC50 0.4 nM
Cc1cc(-c2ccnc(Nc3ccncc3)n2)ccc1CNC(=O)c1cnc(C(C)(C)C)s1 CHEMBL4746275 IC50 0.4 nM
Cc1cc(-c2ccnc(Nc3cnn(C)c3)n2)ccc1CNC(=O)N1CC(CC(C)C)C1 CHEMBL4796367 IC50 0.4 nM
Cn1cc(-c2nc3c(-c4ccc(CNC(=O)c5nc(C(C)(C)C)no5)c(F)c4)ccnc3[nH]2)cn1 CHEMBL4850235 IC50 0.4 nM
Cn1cc(-c2nc3c(-c4ccc(CNC(=O)c5nc(C6(C)CC6)no5)c(F)c4)ccnc3[nH]2)cn1 CHEMBL4865369 IC50 0.4 nM
Cn1cc(-c2nc3c(-c4ccc(CNC(=O)c5noc(C(C)(C)C)n5)c(F)c4)ccnc3[nH]2)cn1 CHEMBL4849220 IC50 0.4 nM
Cc1nn(C(C)C)c(C)c1-c1nc2c(-c3ccc4c(c3)CCCC[C@H]4NC(=O)c3nc(C(C)(C)C)no3)ccnc2[nH]1 CHEMBL4877846 IC50 0.4 nM
C=CC(=O)N1CCC[C@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1 CHEMBL3647964 IC50 0.4 nM
CC(C)OC1CN(C(=O)N[C@@H]2CCCCc3cc(-c4ccnc(Nc5cnn(C)c5)n4)ccc32)C1 CHEMBL5090290 IC50 0.4 nM
CC(C)(/C=C(\C#N)C(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3F)c3c(N)ncnc32)C1)N1CCNCC1 CHEMBL5169419 IC50 0.4 nM
C=CC(=O)N1CCC(CNc2ncnc3[nH]cc(C(=O)N4CC(Oc5cccc(F)c5)C4)c23)CC1 CHEMBL5180302 IC50 0.4 nM
CC(C)(C)CN1CCN(Cc2ccc(-c3ccnc(Nc4cnn(CCO)c4)n3)cc2C(F)(F)F)C(=O)C1 CHEMBL5192152 IC50 0.4 nM
Cc1cc(C(N)=O)c2[nH]c3cc(C(C)(C)O)ccc3c2c1-c1cccc(-n2c(=O)cc3c(Cl)cccn3c2=O)c1C CHEMBL3932965 IC50 0.41 nM
Cc1cc(-c2nc([C@@H]3CC[C@H]4CCC(=O)N4C3)n3ccnc(N)c23)ccc1C(=O)Nc1cc(C(F)(F)F)ccn1 CHEMBL4106497 IC50 0.41 nM
Cn1nc(NC(=O)c2ccc(-c3nc([C@@H]4CC[C@H]5CCC(=O)N5C4)n4ccnc(N)c34)cc2)cc1C(F)(F)F CHEMBL4115636 IC50 0.41 nM
COc1cc(C(=O)Nc2cc(C3CCC3)ccn2)ccc1-c1nc([C@@H]2CC[C@H]3CCC(=O)N3C2)n2c(Cl)cnc(N)c12 CHEMBL4110184 IC50 0.41 nM
C=CC(=O)N1CC[C@]2(C1)C[C@H](n1c(NC(=O)c3ccc(-c4ccnc(N)n4)s3)nc3ccccc31)C2 CHEMBL4217959 IC50 0.41 nM
Nc1nc(Nc2ccc(N3CCOCC3)cc2)nc(-c2cccc(-n3ccc4cc(C5CC5)cc(F)c4c3=O)c2CO)n1 CHEMBL4217816 IC50 0.41 nM
NC(=O)c1c(-c2ccc(Oc3ccc(F)cc3F)cc2)nn([C@@H]2CCCN(C(=O)/C=C/C(F)F)C2)c1N CHEMBL4559065 IC50 0.41 nM
Cc1c(-c2ccc(C(N)=O)c3[nH]c4cc(C(C)(C)O)ccc4c23)cccc1-n1c(=O)cc2c(Cl)cccn2c1=O CHEMBL4751952 IC50 0.41 nM
CC1(C(=O)N2CCC[C@@H](c3nc(-c4ccc(C(=O)Nc5cc(C(F)(F)F)ccn5)c(F)c4F)c4c(N)nccn34)C2)COC1 CHEMBL4787427 IC50 0.41 nM
CCOc1ccnc(NC(=O)c2ccc(-c3nc([C@@H]4CCCN(C(=O)C5(C)COC5)C4)n4ccnc(N)c34)c(F)c2)c1 CHEMBL4764215 IC50 0.41 nM
C=CC(=O)Nc1cccc(Oc2nc(Nc3ccc(NS(=O)(=O)c4ccc(OC)cc4)cc3)ncc2Cl)c1 CHEMBL4071567 IC50 0.42 nM
CC1(C(=O)N2CCC[C@@H](c3nc(-c4ccc(C(=O)Nc5cc(OC(F)(F)Cl)ccn5)cc4F)c4c(N)nccn34)C2)COC1 CHEMBL4743911 IC50 0.42 nM
C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(NC(=O)c4cc5ccccc5s4)c4c3OCO4)c3c(N)ncnc32)C1 CHEMBL5427093 IC50 0.42 nM
CC(C)(C)c1cc(F)c2c(=O)n(-c3cccc(-n4cc(C(N)=O)c(Nc5cnccn5)n4)c3CO)ncc2c1 CHEMBL3652658 IC50 0.43 nM
C=CC(=O)N1CC([C@H]2CCNc3c(C(N)=O)c(-c4ccc(Oc5ccccc5)cc4)nn32)C1 CHEMBL4114482 IC50 0.43 nM
C/C=C/C(=O)N1CCc2[nH]c3c(C(N)=O)c(-c4ccc(Oc5ccccc5)cc4)nn3c2C1 CHEMBL3914651 IC50 0.43 nM
Cn1cc(-c2ccnc(N3CCn4c(cc5c4CC(C)(C)C5)C3=O)c2CO)cc(Nc2ccc(C3CN(C4COC4)C3)cn2)c1=O CHEMBL4069790 Ki 0.43 nM
C[C@@H]1CN(c2ccc(Nc3cc(-c4cc(F)cc(N5CCn6c(cc7c6CCCC7)C5=O)c4CO)cn(C)c3=O)nc2)CCN1C CHEMBL4092794 Ki 0.43 nM
C=CC(=O)N1CC(C2CCNc3c(C(N)=O)c(-c4ccc(Oc5ccccc5)c(Cl)c4)nn32)C1 CHEMBL3985855 IC50 0.44 nM
Cn1nc(NC(=O)c2ccc(-c3nc([C@@H]4CC[C@H]5CCC(=O)N5C4)n4c(Cl)cnc(N)c34)c(OC3CC3)c2)cc1C(F)(F)F CHEMBL4109975 IC50 0.44 nM
C=CC(=O)N(C)CCOc1cnccc1-c1ccc(CN2CCN(CC(C)(C)C)CC2=O)c(C)c1 CHEMBL5188750 IC50 0.44 nM
C=CC(=O)N(C)CCOc1cncnc1-c1ccc(CN2CCN(CC(C)(C)C)CC2=O)c(F)c1 CHEMBL5173641 IC50 0.44 nM
Cc1c(-c2c(F)cc(C(N)=O)c3[nH]c4cc(C(C)(C)O)ccc4c23)cccc1-n1c(=O)c2cccc(F)c2n(C)c1=O CHEMBL3896019 IC50 0.45 nM
Cn1c(=O)n(-c2cccc(-c3c(Cl)cc(C(N)=O)c4[nH]c5cc(C(C)(C)O)ccc5c34)c2Cl)c(=O)c2cccc(F)c21 CHEMBL3903416 IC50 0.45 nM
Cc1c(-c2c(F)cc(C(N)=O)c3[nH]c4c(c23)CC[C@H](C(C)(C)O)C4)cccc1-n1c(=O)[nH]c2c(Cl)cccc2c1=O CHEMBL3955854 IC50 0.45 nM
Nc1ncnc2c1c(-c1ccc(C(=O)Nc3cc(C(F)(F)F)ccn3)cc1)nn2[C@@H]1CCCc2nn(CCO)cc21 CHEMBL4112398 IC50 0.45 nM
Nc1nccn2c([C@@H]3CC[C@H]4CCC(=O)N4C3)nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)c(F)c3)c12 CHEMBL4110290 IC50 0.45 nM
Nc1nccn2c([C@@H]3CC[C@@H]4CC(O)C(=O)N4C3)nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3)c12 CHEMBL4108773 IC50 0.45 nM
CC(C)(C(=O)O)N1CC(=O)N2C[C@H](c3nc(-c4ccc(C(=O)Nc5cc(C(F)(F)F)ccn5)cc4)c4c(N)nccn34)CC[C@H]2C1 CHEMBL4113154 IC50 0.45 nM
CCOc1cc(C(=O)Nc2ncc(C)s2)ccc1-c1nc([C@@H]2CC[C@H]3CCC(=O)N3C2)n2c(Cl)cnc(N)c12 CHEMBL4111910 IC50 0.45 nM
Cn1cc(-c2ccnc(N3CCn4c(cc5c4CC(C)(C)C5)C3=O)c2CO)cc(Nc2ccc(N3CCN(C4CCOCC4)CC3)cn2)c1=O CHEMBL4090117 Ki 0.45 nM
Cc1oncc1C(=O)N1C[C@H](c2nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3F)c3c(N)nccn23)CC[C@@H]1C CHEMBL4764139 IC50 0.45 nM
N#C/N=C1\CC[C@@H]2CC[C@@H](c3nc(-c4ccc(C(=O)Nc5cc(C(F)(F)F)ccn5)cc4)c4c(N)nccn34)CN12 CHEMBL4111520 IC50 0.46 nM
Cc1cc(C(=O)Nc2cc(C(F)(F)F)ccn2)ccc1-c1nc([C@@H]2CC[C@H]3CCC(=O)N3C2)n2ccnc(N)c12 CHEMBL4114033 IC50 0.46 nM
C=CC(=O)N1CC[C@]2(C1)C[C@H](n1c(NC(=O)c3ccc(-c4ccnc(NC)c4)s3)nc3ccccc31)C2 CHEMBL4219011 IC50 0.46 nM
C=CC(=O)Nc1cccc(-c2ccc(C(N)=O)c3[nH]c4cc(C(C)(C)O)ccc4c23)c1C CHEMBL4239747 IC50 0.46 nM
Cn1c(=O)n(-c2cccc(-c3c(Cl)cc(C(N)=O)c4[nH]c5cc(C(C)(C)O)ccc5c34)c2Cl)c(=O)c2ccccc21 CHEMBL3954590 IC50 0.47 nM
COc1cc2nccc(Oc3ccc(C(=O)Nc4ccccn4)cc3)c2cc1NC(=O)C#CCN1CCOCC1 CHEMBL4759528 IC50 0.47 nM
C=CC(=O)N1CC(C2CCNc3c(C(N)=O)c(-c4ccc(Oc5ccccc5)cc4)nn32)C1 CHEMBL3965549 IC50 0.48 nM
C=CC(=O)N1CC(C2CCNc3c(C(N)=O)c(-c4ccc(Oc5cccc(Cl)c5)cc4)nn32)C1 CHEMBL3929217 IC50 0.48 nM
Nc1nccn2c([C@@H]3CC[C@H]4CCC(=O)N4C3)nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3OC(F)F)c12 CHEMBL4111338 IC50 0.48 nM
Cc1c(-c2c(F)cc(C(N)=O)c3[nH]c4c(c23)CC[C@@H](C(C)(C)O)C4)cccc1-n1c(=O)[nH]c2c(F)cccc2c1=O CHEMBL4114536 IC50 0.49 nM
Cc1c(-c2c(C#N)cc(C(N)=O)c3[nH]c4cc(C(C)(C)O)ccc4c23)cccc1-n1c(=O)cc2c(Cl)cccn2c1=O CHEMBL3965224 IC50 0.49 nM
C=CC(=O)Nc1ccccc1C1CCNc2c(C(N)=O)c(-c3ccc(Cl)c(OC)c3)nn21 CHEMBL3959393 IC50 0.49 nM
CC(C1CC1)n1cc(Nc2nc(N)nc(-c3cccc(-n4ccc5cc(C6CC6)cc(F)c5c4=O)c3CO)n2)cn1 CHEMBL4211893 IC50 0.49 nM
Cc1c(-c2ccc(C(N)=O)c3[nH]c4cc(C(C)(C)O)ccc4c23)cccc1-n1c(=O)cc2cc(Cl)ccn2c1=O CHEMBL4741099 IC50 0.49 nM
C=CC(=O)NCCN(C)c1cccc(Nc2cc(-c3cc(F)cc(-n4ncc5c6c(sc5c4=O)CCCC6)c3CO)cn(C)c2=O)n1 CHEMBL3966856 Ki 0.494 nM
C=CC(=O)Nc1cccc(N(C)c2nc(Nc3cccc(OCCCN(C)C(=O)CCCC(=O)NCCCOCCOCCOCCCNC(=O)CCCC[C@H]4SC[C@H]5NC(=O)N[C@H]54)c3)ncc2C)c1 CHEMBL3397911 IC50(app) 0.5 nM
Cc1c(-c2c(F)cc(C(N)=O)c3[nH]c4c(c23)CC[C@H](C(C)(C)O)C4)cccc1-n1c(=O)c2cccc(F)c2n(C)c1=O CHEMBL3900554 IC50 0.5 nM
C=CC(=O)Nc1cccc(-n2cnc3cnc(Nc4ccc(N5CCN(C(C)=O)C(C)C5)cc4)nc32)c1 CHEMBL3953720 IC50 0.5 nM
C=CC(=O)Nc1cccc(-n2cnc3cnc(Nc4ccc(N5CCN(CC)CC5)cc4)nc32)c1 CHEMBL3966494 IC50 0.5 nM
COc1cc(C(=O)Nc2cc(C3CC3)ccn2)ccc1-c1nc([C@@H]2CC[C@H]3[C@@H](C)OC(=O)N3C2)n2ccnc(N)c12 CHEMBL4106896 IC50 0.5 nM
Nc1ncc(Cl)n2c([C@@H]3CC[C@H]4CCC(=O)N4C3)nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3OC3CC3)c12 CHEMBL4110893 IC50 0.5 nM
Nc1nccn2c([C@@H]3CCC[C@H](c4nn[nH]n4)C3)nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3)c12 CHEMBL4062247 IC50 0.5 nM
Nc1nccn2c([C@@H]3CCC[C@H](c4n[nH]c(=O)o4)C3)nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3)c12 CHEMBL4059483 IC50 0.5 nM
Nc1nccn2c1c(-c1ccc(C(=O)Nc3cc(C(F)(F)F)ccn3)cc1)nc2[C@H]1CC[C@@H](C(=O)O)CC1 CHEMBL4074674 IC50 0.5 nM
C=CC(=O)N[C@@H]1Cn2c(c(-c3ccc(C(=O)Nc4ccccn4)cc3)c3c(N)ncnc32)C1=C CHEMBL4206284 IC50 0.5 nM
C=CC(=O)Nc1cccc(Nc2nc(Nc3ccc(OCCCN4CCN(CC)CC4)c(Cl)c3)ncc2Cl)c1 CHEMBL4294772 IC50 0.5 nM
C=CC(=O)N[C@H]1CCN(c2ncc(C(N)=O)c(Nc3ccc(C(=O)N4CCOCC4)cc3)n2)C1 CHEMBL4290540 IC50 0.5 nM
N#CN1CCC[C@@H](n2nc(-c3ccc(Oc4ccc(F)cc4F)cc3)c(C(N)=O)c2N)C1 CHEMBL4560385 IC50 0.5 nM
Cn1cc(-c2nc3c(-c4ccc(CNC(=O)c5cc(C(C)(C)C)no5)c(F)c4)ccnc3[nH]2)cn1 CHEMBL4857263 IC50 0.5 nM
Cn1cc(-c2nc3c(-c4ccc(CNC(=O)c5cc6c(s5)CCCC6)c(F)c4)ccnc3[nH]2)cn1 CHEMBL4871425 IC50 0.5 nM
Cc1c(-c2nc3c(-c4ccc5c(c4)CCC[C@H]5NC(=O)c4nc(C(C)(C)C)no4)ccnc3[nH]2)cnn1C1CCOCC1 CHEMBL4876326 IC50 0.5 nM
CC(C)C1CCN(C(=O)NC2CCCCc3cc(-c4ccnc(Nc5cnn(C)c5)n4)ccc32)C1 CHEMBL5087183 IC50 0.5 nM
Cn1cc(Nc2nccc(-c3ccc4c(c3)CCCCC4NC(=O)c3nnc(C(C)(C)C)o3)n2)cn1 CHEMBL5090589 IC50 0.5 nM
COCCN1CC[C@@H](NC(=O)c2cn(C(C)(C)C)nn2)c2ccc(-c3ccnc(Nc4cnn(C)c4)n3)cc2C1 CHEMBL5093189 IC50 0.5 nM
C=CC(=O)N1CCC(CNc2ncnc3[nH]cc(C(=O)N4CC(Oc5cccc(C)c5)C4)c23)CC1 CHEMBL5192748 IC50 0.5 nM
C=CC(=O)N1CCC(CNc2ncnc3[nH]cc(C(=O)N4CC(Oc5cccc(Cl)c5)C4)c23)CC1 CHEMBL5195504 IC50 0.5 nM
C=CC(=O)N1CCC([C@@H]2CCNC3C(C(N)=O)C(c4ccc(Oc5ccccc5)cc4)=NN32)CC1 CHEMBL5193128 IC50 0.5 nM
CNc1ncc2cc(-c3cc(OC)cc(OC)c3Cl)c(=O)n(CCc3ccc(NC(=O)/C(C#N)=C/C(C)(C)N)cc3)c2n1 CHEMBL5279959 IC50 0.5 nM
C=CC(=O)Nc1cccc(Nc2nc(Nc3ccc(OCCOC)cc3)ncc2F)c1 CHEMBL3301625 IC50 0.5 nM
Cc1c(-c2c(F)cc(C(N)=O)c3[nH]c4c(c23)CC[C@H](C(C)(C)O)C4)cccc1N1C(=O)c2cccc(F)c2C(C)C1=O CHEMBL5290606 IC50 0.5 nM
C=CC(=O)N1CC[C@@H](Nc2ncnc(N)c2-c2ccc(Oc3ccccc3)cc2)C1 CHEMBL5275119 IC50 0.5 nM
COc1ccc(F)cc1C(=O)NCc1ccc(-c2nn(C3CCCC3)c3c(=O)[nH]nc(N)c23)cc1 CHEMBL5434427 IC50 0.5 nM
Cc1cc(Nc2nn(-c3cccc(-n4ncc5cc(C(C)(C)C)ccc5c4=O)c3CO)cc2C(N)=O)nn1C CHEMBL3652663 IC50 0.51 nM
C=CC(=O)Nc1ccccc1[C@H]1CCNc2c(C(N)=O)c(-c3ccc(OCc4ccccc4)cc3)nn21 CHEMBL4109100 IC50 0.51 nM
COc1cc(C(=O)Nc2cc(C(F)(F)F)ccn2)ccc1-c1nc([C@@H]2CC[C@H]3CC(C)(C)C(=O)N3C2)n2ccnc(N)c12 CHEMBL4112030 IC50 0.51 nM
Nc1nc(Nc2cn[nH]c2)nc(-c2cccc(-n3ccc4cc(C5CC5)cc(F)c4c3=O)c2CO)n1 CHEMBL4214343 IC50 0.51 nM
C=CS(=O)(=O)N1CCCC(n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1 CHEMBL3647968 IC50 0.52 nM
C=CS(=O)(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1 CHEMBL4107734 IC50 0.52 nM
Nc1ncnc2c1c(-c1ccc(C(=O)Nc3cc(C(F)(F)F)ccn3)cc1)nn2[C@@H]1CCCc2[nH]ncc21 CHEMBL4113933 IC50 0.52 nM
Nc1nccn2c([C@@H]3CC[C@H]4CCC(=O)N4C3)nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)c(Cl)c3)c12 CHEMBL4107273 IC50 0.52 nM
COc1cc(C(=O)Nc2cc(C(F)(F)F)ccn2)ccc1-c1nc([C@H]2CN3C(=O)CC[C@@H]3CO2)n2ccnc(N)c12 CHEMBL4114251 IC50 0.52 nM
Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)nn2C1CCCN(C(=O)/C=C/Cl)C1 CHEMBL4280795 IC50 0.52 nM
CC#CC(=O)N[C@H]1CCCN(c2ccc(C(N)=O)c3[nH]c(C)c(C)c23)C1 CHEMBL4642827 IC50 0.52 nM
COc1cccn2c(=O)n(-c3cccc(-c4ccc(C(N)=O)c5[nH]c6cc(C(C)(C)O)ccc6c45)c3C)c(=O)cc12 CHEMBL4754459 IC50 0.52 nM
C[C@H]1CC[C@@H](c2nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3F)c3c(N)nccn23)CN1C(=O)C1(O)CCC1 CHEMBL4788780 IC50 0.52 nM
CC1(C(=O)N2CCC[C@@H](c3nc(-c4ccc(C(=O)Nc5cc(OC6CC6)ccn5)cc4F)c4c(N)nccn34)C2)COC1 CHEMBL4757180 IC50 0.52 nM
C=CC(=O)Nc1ccccc1C1CCNc2c(C(N)=O)c(-c3ccc(C)c(OC)c3)nn21 CHEMBL3917828 IC50 0.53 nM
C[C@@H]1OC(=O)N2C[C@H](c3nc(-c4ccc(C(=O)Nc5cc(C6CC6)ccn5)cc4)c4c(N)nccn34)CC[C@@H]12 CHEMBL3952685 IC50 0.53 nM
C=CC(=O)N1CC[C@]2(C1)C[C@H](n1c(NC(=O)c3ccc(-c4cnco4)s3)nc3cc(CN[C@H]4CC[C@H](O)CC4)ccc31)C2 CHEMBL4216529 IC50 0.53 nM
CC(C)n1cc(Nc2nc(N)nc(-c3cccc(-n4ccc5cc(C6CC6)cc(F)c5c4=O)c3CO)n2)cc1C#N CHEMBL4208062 IC50 0.53 nM
CC1(C(=O)N2CCC[C@@H](c3nc(-c4ccc(C(=O)Nc5cc(-n6cccn6)ccn5)cc4F)c4c(N)nccn34)C2)COC1 CHEMBL4783242 IC50 0.53 nM
CC(C)N1Cc2cc(cc(F)c2Cl)O[C@@H](C)CNC(=O)c2cnn3cc1cnc23 CHEMBL4554856 IC50 0.536 nM
CC(F)(F)c1ccnc(NC(=O)c2ccc(-c3nc([C@@H]4CC[C@H]5CCC(=O)N5C4)n4ccnc(N)c34)cc2F)c1 CHEMBL4115042 IC50 0.54 nM
CCOc1cc(C(=O)Nc2cc(C(F)(F)F)ccn2)ccc1-c1nc([C@@H]2CC[C@H]3CC(C)(C)C(=O)N3C2)n2ccnc(N)c12 CHEMBL4110940 IC50 0.54 nM
COCCOCCn1cc(Nc2nc(N)nc(-c3cccc(-n4ccc5cc(C6CC6)cc(F)c5c4=O)c3CO)n2)cc1C#N CHEMBL4212436 IC50 0.54 nM
C[C@H]1CC[C@@H](c2nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3F)c3c(N)nccn23)CN1C(=O)C(C)(C)CO CHEMBL4781173 IC50 0.54 nM
CC#CC(=O)Nc1cc2c(Oc3ccc(C(=O)Nc4ccccn4)cc3)ccnc2cc1OCCN1CCOCC1 CHEMBL4782725 IC50 0.54 nM
CN(C)C(=O)N1CC=C(c2cc3c(-c4cccc(-n5ccc6cc(C7CC7)cc(F)c6c5=O)c4CO)nc(N)nc3[nH]2)CC1 CHEMBL5091956 IC50 0.54 nM
O=C1c2c(F)cc(C3CC3)cc2OCCN1c1cc(F)cc(-c2ccnc3[nH]c(-c4ccc(CN5CCOCC5)cn4)cc23)c1CO CHEMBL3967515 IC50 0.55 nM
C=CC(=O)Nc1ccccc1C1CCNc2c(C(N)=O)c(-c3ccc(Cl)c(Cl)c3)nn21 CHEMBL3891595 IC50 0.55 nM
CCOc1cc(C(=O)Nc2cc(C(F)(F)F)ccn2)c(F)cc1-c1nc([C@@H]2CC[C@H]3CCC(=O)N3C2)n2c(Cl)cnc(N)c12 CHEMBL4108221 IC50 0.55 nM
CNC(=O)[C@H]1Cc2c([nH]c3ccccc23)CN1C(=O)c1occc1CNc1ccc2nccnc2c1 CHEMBL4850816 IC50 0.55 nM
CC(C)(C)c1ccc2c(=O)n(-c3cccc(-n4cc(C(N)=O)c(Nc5ccc(F)cn5)n4)c3CO)ncc2c1 CHEMBL3652664 IC50 0.56 nM
Cc1c(-c2c(F)cc(C(N)=O)c3[nH]c4c(c23)CC[C@H](C(C)(C)O)C4)cccc1-n1c(=O)cc2c(F)cccn2c1=O CHEMBL3901137 IC50 0.56 nM
CC(C)(C)c1cc(F)c2c(=O)n(-c3cccc(-n4cc(C(N)=O)c(Nc5ccc(C(F)(F)F)cn5)n4)c3CO)ncc2c1 CHEMBL3652661 IC50 0.57 nM
Nc1nccn2c([C@@H]3CC[C@H]4CCC(=O)N4C3)nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3Cl)c12 CHEMBL4108437 IC50 0.57 nM
Nc1nc(Nc2cnn(C3CC3)c2)nc(-c2cccc(-n3ccc4cc(C5CC5)cc(F)c4c3=O)c2CO)n1 CHEMBL4216862 IC50 0.57 nM
C=CC(=O)N1CCC([C@@H]2CCNc3c(C(N)=O)c(-c4cc(OC)c(Br)c(OC)c4)nn32)CC1 CHEMBL5275348 IC50 0.57 nM
C=C(C#N)C(=O)NCCOc1cccc(Nc2cc(-c3cc(F)cc(-n4ncc5c6c(sc5c4=O)CCCC6)c3CO)cn(C)c2=O)n1 CHEMBL3967905 Ki 0.576 nM
C=CC(=O)N[C@H]1CC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)CC1 CHEMBL3647967 IC50 0.58 nM
Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)nn2C1CCCN(C(=O)CCl)C1 CHEMBL3647972 IC50 0.58 nM
C=CC(=O)N1CCC(n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)CC1 CHEMBL3647973 IC50 0.58 nM
Nc1nccn2c([C@@H]3CC[C@H]4CCC(=O)N4C3)nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3O)c12 CHEMBL4110993 IC50 0.58 nM
Nc1nccn2c([C@@H]3CC[C@H]4CCC(=O)N4C3)nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3OC3CC3)c12 CHEMBL4107779 IC50 0.58 nM
CCc1ccnc(NC(=O)c2ccc(-c3nc([C@@H]4CC[C@H]5CCC(=O)N5C4)n4c(Cl)cnc(N)c34)c(OC)c2)c1 CHEMBL4106492 IC50 0.58 nM
CC1C=C(c2ccnc(N3CCc4c(sc5c4CC(C)(C)C5)C3=O)c2CO)C=C(Nc2ccc(N3CCN(C4COC4)CC3)cc2)C1=O CHEMBL4063638 Ki 0.58 nM
CCn1cc(Nc2nc(N)nc(-c3cccc(-n4ccc5cc(C6CC6)cc(F)c5c4=O)c3CO)n2)cc1C#N CHEMBL4216339 IC50 0.58 nM
CN1CCN(C(=O)N2CC=C(c3cc4c(-c5cccc(-n6ccc7cc(C8CC8)cc(F)c7c6=O)c5CO)nc(N)nc4[nH]3)CC2)CC1 CHEMBL5074640 IC50 0.58 nM
Cc1c(-c2c(F)cc(C(N)=O)c3[nH]c4cc(CCO)ccc4c23)cccc1-n1c(=O)cc2c(F)cccn2c1=O CHEMBL3959154 IC50 0.59 nM
Cn1nc(NC(=O)c2ccc(-c3nc([C@@H]4CC[C@H]5CCC(=O)N5C4)n4ccnc(N)c34)c(OC3CC3)c2)cc1C(F)(F)F CHEMBL4110307 IC50 0.59 nM
Nc1nccn2c([C@H]3CN(C4CCOCC4)CCO3)nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3F)c12 CHEMBL4060757 IC50 0.59 nM
C=CC(=O)N(C)c1cccc(-c2ccc(C(N)=O)c3[nH]c(C)c(C)c23)c1C CHEMBL4242058 IC50 0.59 nM
CN(C1COC1)C(C)(C)/C=C(\C#N)C(=O)N1CCC[C@H](n2nc(-c3ccc(Oc4ccccc4)cc3F)c3c(N)ncnc32)C1 CHEMBL3941568 IC50 0.6 nM
CC(C)(C)N1CCN(C(C)(C)/C=C(\C#N)C(=O)N2CCC[C@H](n3nc(-c4ccc(Oc5ccccc5)cc4F)c4c(N)ncnc43)C2)CC1 CHEMBL3890663 IC50 0.6 nM
N#C/C(=C\C1CC1)C(=O)N1CCC[C@H]1Cn1nc(-c2ccc(Oc3ccccc3)cc2F)c2c(N)ncnc21 CHEMBL4114690 IC50 0.6 nM
CN(C1COC1)C(C)(C)/C=C(\C#N)C(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3F)c3c(N)ncnc32)C1 CHEMBL3702839 IC50 0.6 nM
CC(C)(C)N1CCN(C(C)(C)/C=C(\C#N)C(=O)N2CCC[C@@H](n3nc(-c4ccc(Oc5ccccc5)cc4F)c4c(N)ncnc43)C2)CC1 CHEMBL3702849 IC50 0.6 nM
C=CC(=O)NC[C@H]1CCNc2c(C(N)=O)c(-c3ccc(Oc4ccccc4)cc3)nn21 CHEMBL4109830 IC50 0.6 nM
Cn1nnc([C@H]2CCC[C@@H](c3nc(-c4ccc(C(=O)Nc5cc(C(F)(F)F)ccn5)cc4)c4c(N)nccn34)C2)n1 CHEMBL4082411 IC50 0.6 nM
Nc1cc(-c2cccc(-n3ccc4cc(C5CC5)cc(F)c4c3=O)c2CO)nc(Nc2cnn(C3(CO)CC3)c2)n1 CHEMBL4210972 IC50 0.6 nM
CC(C)(C)n1cc(Nc2nc(N)cc(-c3cccc(-n4ccc5cc(C6CC6)cc(F)c5c4=O)c3CO)n2)cn1 CHEMBL4208439 IC50 0.6 nM
Nc1cc(-c2cccc(-n3ccc4cc(C5CC5)cc(F)c4c3=O)c2CO)nc(Nc2cn[nH]c2)n1 CHEMBL4214732 IC50 0.6 nM
Nc1cc(-c2cccc(-n3ccc4cc(C5CC5)cc(F)c4c3=O)c2CO)nc(Nc2ccc(N3CCOCC3)cc2)n1 CHEMBL4206900 IC50 0.6 nM
C=CC(=O)Nc1cccc(Nc2nc(Nc3ccc(OCCCN4CCOCC4)cc3)ncc2Cl)c1 CHEMBL4290692 IC50 0.6 nM
C=CC(=O)N[C@H]1CCN(c2ccc(C(N)=O)c(Nc3ccc(N4C[C@@H](C)O[C@@H](C)C4)cc3)n2)C1 CHEMBL4281335 IC50 0.6 nM
Nc1ncnc(NCC2CCN(C(=O)CCl)CC2)c1-c1ccc(Oc2ccccc2)cc1 CHEMBL4532368 IC50 0.6 nM
C=CC(=O)Nc1cccc(Nc2nc(Nc3ccc4c(c3)COB4O)ncc2C(F)(F)F)c1 CHEMBL4642642 IC50 0.6 nM
C=CS(=O)(=O)N[C@H]1CCCN(c2ccc(C(N)=O)c3[nH]c(C)c(C)c23)C1 CHEMBL4645440 IC50 0.6 nM
Cc1c(NC(=O)c2ccc(C3CC3)cc2)cc(F)cc1-c1ncnc2[nH]cc(C3=CCN(C(=O)/C=C/CN4CCCC4)CC3)c12 CHEMBL4749522 IC50 0.6 nM
Cc1nn(C(C)C)c(C)c1-c1nc2c(-c3ccc4c(c3)CCC[C@H]4NC(=O)c3nc(C(C)(C)C)no3)ccnc2[nH]1 CHEMBL4862532 IC50 0.6 nM
CC(C)(/C=C(\C#N)C(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3F)c3c(N)ncnc32)C1)N1CCOCC1 CHEMBL5191633 IC50 0.6 nM
C=CC(=O)N1CCC(CNc2ncnc3[nH]cc(C(=O)N4CC(Oc5ccccc5)C4)c23)CC1 CHEMBL5208265 IC50 0.6 nM
Cc1c(NC(=O)c2ccc(C(C)(C)C)cc2)cccc1-c1cn(C)c(=O)c(Nc2ccc(C(=O)N3CCN(C(=S)Nc4ccc(-c5c6ccc(=O)cc-6oc6cc(O)ccc56)c(C(=O)O)c4)CC3)cc2)n1 CHEMBL3402355 IC50 0.61 nM
Cc1c(NC(=O)c2ccc(C(C)(C)C)cc2)cccc1-c1cn(C)c(=O)c(Nc2ccc(C(=O)N3CCOCC3)cc2)n1 CHEMBL1230541 IC50 0.61 nM
C=CC(=O)N[C@@H](C)COc1cccc(Nc2cc(-c3ccnc(N4CCn5c(cc6c5CC(C)(C)C6)C4=O)c3CO)cn(C)c2=O)n1 CHEMBL3890374 Ki 0.612 nM
Cc1c(-c2c(Cl)cc(C(N)=O)c3[nH]c4cc(C(C)(C)O)ccc4c23)cccc1-n1c(=O)c2ccc(F)cc2n(C)c1=O CHEMBL3946439 IC50 0.62 nM
CN(C)C/C=C/C(=O)N1CCCc2[nH]c3c(C(N)=O)c(-c4ccc(Oc5ccccc5)cc4)nn3c2C1 CHEMBL3959966 IC50 0.62 nM
C=CC(=O)N1CC[C@]2(C1)C[C@H](n1c(NC(=O)c3ccc(-c4cnco4)s3)nc3cc(NC)ccc31)C2 CHEMBL4216187 IC50 0.62 nM
CC1(C)Cc2cc3n(c2C1)CCN(c1cccc(-c2nc(N)nc(Nc4ccc(N5CCOCC5)cc4)n2)c1CO)C3=O CHEMBL4212860 IC50 0.62 nM
CCOc1cc(C(=O)Nc2ncc(C)s2)ccc1-c1nc([C@@H]2CC[C@H]3CCC(=O)N3C2)n2ccnc(N)c12 CHEMBL4109249 IC50 0.63 nM
Cc1cnc(NC(=O)c2ccc(-c3nc([C@@H]4CC[C@H]5CCC(=O)N5C4)n4ccnc(N)c34)c(Cl)c2)s1 CHEMBL4108011 IC50 0.63 nM
C=CC(=O)N1CC[C@]2(C1)C[C@H](n1c(NC(=O)c3ccc(-c4ccnc(N)c4)s3)nc3ccccc31)C2 CHEMBL4207292 IC50 0.63 nM
COc1ccn2c(=O)n(-c3cccc(-c4ccc(C(N)=O)c5[nH]c6cc(C(C)(C)O)ccc6c45)c3C)c(=O)cc2c1 CHEMBL4789404 IC50 0.63 nM
C=CC(=O)Nc1ccccc1[C@H]1CCNc2c(C(N)=O)c(-c3ccc(Cl)cc3)nn21 CHEMBL4112625 IC50 0.64 nM
Cc1cc(-c2nc([C@@H]3CC[C@H]4CCC(=O)N4C3)n3ccnc(N)c23)ccc1C(=O)Nc1cc(C2CC2)ccn1 CHEMBL4112420 IC50 0.64 nM
Cn1nc(NC(=O)c2ccc(-c3nc([C@@H]4CC[C@H]5CCC(=O)N5C4)n4c(Cl)cnc(N)c34)cc2)cc1C(F)(F)F CHEMBL4110832 IC50 0.64 nM
C=CC(=O)N1CC[C@]2(C1)C[C@H](n1c(NC(=O)c3ccc(-c4cnco4)s3)nc3cc(CN[C@@H](C)C(C)(C)C)ccc31)C2 CHEMBL4203077 IC50 0.64 nM
N#CN1CCC[C@@H](n2nc(-c3ccc(Oc4ccc(Cl)cc4)cc3)c(C(N)=O)c2N)C1 CHEMBL4456283 IC50 0.64 nM
C=CC(=O)Nc1ccccc1C1CCNc2c(C(N)=O)c(-c3ccc(Cl)cc3)nn21 CHEMBL3910697 IC50 0.64 nM
Cc1cc(C(N)=O)c2[nH]c3cc(C(C)(C)O)ccc3c2c1-c1cccc(-n2c(=O)c3cccc(F)c3n(C)c2=O)c1C CHEMBL3931086 IC50 0.65 nM
O=C1c2c(F)cc(C3CC3)cc2OCCN1c1cc(F)cc(-c2ccnc3[nH]c(-c4ccc(CN5CCN(CC(F)F)CC5)cn4)cc23)c1CO CHEMBL3929445 IC50 0.65 nM
Cc1c(-c2c(Cl)cc(C(N)=O)c3[nH]c4cc(C(C)(C)O)ccc4c23)cccc1-n1c(=O)c2cc(F)ccc2n(C)c1=O CHEMBL3918568 IC50 0.65 nM
C[C@H]1CN(C)CCN1c1ccc(Nc2cc(-c3cc(F)cc(N4CCn5c(cc6c5CCCC6)C4=O)c3CO)cn(C)c2=O)nc1 CHEMBL4085043 Ki 0.65 nM
Nc1nc(-c2cccc(-n3ccc4cc(C5CC5)cc(F)c4c3=O)c2CO)c2cc(C3=CCNCC3)[nH]c2n1 CHEMBL5072020 IC50 0.65 nM
C=CC(=O)N(C)CCOc1cnccc1-c1ccc(CN2CCN(CC(C)C)CC2=O)c(C)c1 CHEMBL5197926 IC50 0.65 nM
C=CC(=O)N1CC[C@@H]2[C@H](CNc3c(C(N)=O)c(-c4ccc(Oc5ccccc5)cc4)nn32)C1 CHEMBL4111503 IC50 0.66 nM
C=CC(=O)N1CC[C@]2(C1)C[C@H](n1c(NC(=O)c3ccc(-c4cnco4)s3)nc3cc(CNCC(C)(C)CO)ccc31)C2 CHEMBL4215147 IC50 0.66 nM
C=CC(=O)N1CCC[C@@H]1Cn1nc(-c2ccc(Oc3ccccc3)cc2)c2c(N)ncnc21 CHEMBL4109796 IC50 0.67 nM
NC(=O)c1c(-c2ccc(Oc3ccccc3)cc2)nn2c1NCC[C@H]2C1CCN(C(=O)C#CCO)CC1 CHEMBL3940423 IC50 0.67 nM
Nc1nccn2c([C@@H]3CC[C@H]4CCCN4C3)nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3)c12 CHEMBL4106651 IC50 0.67 nM
CCOc1cc(C(=O)Nc2cc(C(F)(F)F)n(C)n2)c(F)cc1-c1nc([C@@H]2CC[C@H]3CCC(=O)N3C2)n2c(Cl)cnc(N)c12 CHEMBL4112880 IC50 0.67 nM
Cc1c(NC(=O)c2ccc(C(C)(C)C)cc2)cccc1-c1nc(N)nc(Nc2ccc(C(=O)N3CCOCC3)cc2)n1 CHEMBL4209148 IC50 0.67 nM
C=CC(=O)N1CC[C@]2(C1)C[C@H](n1c(NC(=O)c3ccc(-c4ccnc(C)n4)s3)nc3ccccc31)C2 CHEMBL4214683 IC50 0.68 nM
C=CC(=O)NCCN(C)c1cccc(Nc2cc(-c3ccnc(N4CCn5c(cc6c5CC(C)(C)C6)C4=O)c3CO)cn(C)c2=O)n1 CHEMBL3950730 Ki 0.683 nM
Cn1cc(-c2cc(F)cc(N3CCn4c(cc5c4CCCC5)C3=O)c2CO)cc(Nc2ccc(N3CCN(C4COC4)CC3)cn2)c1=O CHEMBL3670095 Ki 0.69 nM
Nc1nc(-c2cccc(-n3ccc4cc(C5CC5)cc(F)c4c3=O)c2CO)c2cc(C3=CCN(C(=O)CN4CCOCC4)CC3)[nH]c2n1 CHEMBL5083974 IC50 0.69 nM
C=CC(=O)N(C)CCOc1c(-c2ccc(CN3CCN(CC(C)C)CC3=O)c(C)c2)ccnc1N CHEMBL5170448 IC50 0.69 nM
Cc1ccccc1Nc1nc2cc(F)c(N(C)C(=O)/C=C/CN(C)C)cc2n2cncc12 CHEMBL1916891 IC50 0.7 nM
Cc1c(-c2ccc(C(N)=O)c3[nH]c4cc(C(O)CO)ccc4c23)cccc1-n1cnc2ccc(F)cc2c1=O CHEMBL2057919 IC50 0.7 nM
Nc1n[nH]c2cc(-c3ccc(C(=O)Nc4nnn[nH]4)cc3)nc(-c3ccc(Oc4ccccc4)cc3)c12 CHEMBL3639560 IC50 0.7 nM
CC(C)(/C=C(\C#N)C(=O)N1CCC[C@H](n2nc(-c3ccc(Oc4ccccc4)cc3F)c3c(N)ncnc32)C1)N1CCC(O)CC1 CHEMBL3967056 IC50 0.7 nM
CC(C)N1CCN(C(C)(C)/C=C(\C#N)C(=O)N2CCC[C@H](n3nc(-c4ccc(Oc5ccccc5)cc4F)c4c(N)ncnc43)C2)CC1 CHEMBL3918726 IC50 0.7 nM
C[C@H](Cn1nc(-c2ccc(Oc3ccccc3)cc2F)c2c(N)ncnc21)NC(=O)/C(C#N)=C/C(C)(C)N CHEMBL4114762 IC50 0.7 nM
CC(C)(/C=C(\C#N)C(=O)N1CCC[C@H]1Cn1nc(-c2ccc(Oc3ccccc3)cc2F)c2c(N)ncnc21)N1CCOCC1 CHEMBL3892680 IC50 0.7 nM
CC(C)(/C=C(\C#N)C(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3F)c3c(N)ncnc32)C1)N1CCC(O)CC1 CHEMBL3702844 IC50 0.7 nM
CC(C)N1CCN(C(C)(C)/C=C(\C#N)C(=O)N2CCC[C@@H](n3nc(-c4ccc(Oc5ccccc5)cc4F)c4c(N)ncnc43)C2)CC1 CHEMBL3702848 IC50 0.7 nM
CC1(C(=O)N2CCO[C@@H](c3nc(-c4ccc(C(=O)Nc5cc(C(F)(F)F)ccn5)cc4F)c4c(N)nccn34)C2)CCC1 CHEMBL4059723 IC50 0.7 nM
C=CC(=O)N1CC[C@]2(C1)C[C@H](n1c(NC(=O)c3ccns3)nc3cc(CN[C@@H](C)C(C)(C)C)ccc31)C2 CHEMBL4215807 IC50 0.7 nM
C=CC(=O)N1C[C@@H]2C[C@H]1CN2c1ccc(C(N)=O)c(Oc2ccc(Oc3ccccc3)cc2)n1 CHEMBL4242598 IC50 0.7 nM
C=CC(=O)Nc1cccc(Nc2nc(Nc3ccc(OCCCN4CCOCC4)c(Cl)c3)ncc2Cl)c1 CHEMBL4284156 IC50 0.7 nM
C=CC(=O)Nc1cccc(Nc2nc(Nc3ccc(OC)c(OCCCN4CCOCC4)c3)ncc2F)c1 CHEMBL4290449 IC50 0.7 nM
C=CC(=O)N1CCC[C@@H](n2c(=O)n(-c3ccc(Oc4ccccc4)cc3)c3c(N)nccc32)C1 CHEMBL4650323 IC50 0.7 nM
CC(C)(C)c1noc(C(=O)NCc2ccc(-c3ccnc4[nH]c(-c5cnn(C6CCOCC6)c5)nc34)cc2F)n1 CHEMBL4861612 IC50 0.7 nM
Cn1cc(-c2nc3c(-c4ccc5c(c4)CCCC5NC(=O)c4nc(C(C)(C)C)no4)ccnc3[nH]2)cn1 CHEMBL4855860 IC50 0.7 nM
CC(C)OC1CN(C(=O)NCc2ccc(-c3ccnc(Nc4cnn(C)c4)n3)cc2C(F)(F)F)C1 CHEMBL5073223 IC50 0.7 nM
CC(C)OC1CN(C(=O)NC2CCCCC3C=C(c4ccnc(Nc5cnn(C)c5)n4)C=CC32)C1 CHEMBL5091935 IC50 0.7 nM
C=CC(=O)Nc1cccc(-n2c(=O)c(-c3ccccc3F)nc3cnc(Nc4ccc(OCCOC)cc4)nc32)c1 CHEMBL5069609 IC50 0.7 nM
C=CC(=O)N1CCC(CNc2ncnc3[nH]cc(C(=O)N4CC(Oc5ccc(F)cc5)C4)c23)CC1 CHEMBL5206496 IC50 0.7 nM
C=CC(=O)N1CC=C(c2c[nH]c3ncnc(-c4ccc(CNC(=O)c5ccccc5)c(F)c4)c23)CC1 CHEMBL5193942 IC50 0.7 nM
C=CC(=O)N1CCC([C@@H]2CCNc3c(C(N)=O)c(-c4cc(OC)c(C5CC5)c(OC)c4)nn32)CC1 CHEMBL5288751 IC50 0.7 nM
CC1(C(=O)N2CCC[C@@H](c3nc(-c4ccc(C(=O)Nc5cc(C(F)F)ccn5)cc4F)c4c(N)nccn34)C2)COC1 CHEMBL4800034 IC50 0.71 nM
CC(=O)N1CC=C(c2cc3c(-c4cccc(-n5ccc6cc(C7CC7)cc(F)c6c5=O)c4CO)nc(N)nc3[nH]2)CC1 CHEMBL5076374 IC50 0.71 nM
C#CC(=O)N1CCCC(n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1 CHEMBL3647969 IC50 0.72 nM
CCOc1cc(C(=O)Nc2cc(C(F)(F)F)ccn2)ccc1-c1nc([C@@H]2CC[C@H]3CCC(=O)N3C2)n2c(C(F)(F)F)cnc(N)c12 CHEMBL4107513 IC50 0.72 nM
CC#CC(=O)N1CC[C@]2(C1)C[C@@H](n1nc(-c3ccc(Oc4ccccc4)cn3)c3c(N)ncnc31)C2 CHEMBL3647526 IC50 0.74 nM
CCOc1cc(C(=O)Nc2cc(C(F)(F)F)n(C)n2)ccc1-c1nc([C@@H]2CC[C@H]3CCC(=O)N3C2)n2ccnc(N)c12 CHEMBL4111802 IC50 0.74 nM
CC(C)(C)c1ccc(C(=O)Nc2cccc(-c3nc(N)nc(Nc4ccc(N5CCOCC5)cc4)n3)c2CO)cc1 CHEMBL4217003 IC50 0.74 nM
CC1(C(=O)N2CCC[C@@H](c3nc(-c4ccc(C(=O)Nc5cc(C6CC6)ccn5)cc4F)c4c(N)nccn34)C2)COC1 CHEMBL4794031 IC50 0.74 nM
CCN1CC(C(=O)N2CC=C(c3cc4c(-c5cccc(N6CCOc7cc(C8CC8)cc(F)c7C6=O)c5CO)ccnc4[nH]3)CC2)C1 CHEMBL3923814 IC50 0.75 nM
Nc1ncc(Cl)n2c([C@@H]3CC[C@H]4CCC(=O)N4C3)nc(-c3ccc(C(=O)Nc4cc(C5CC5)ccn4)cc3OC3CC3)c12 CHEMBL4115167 IC50 0.75 nM
CCOc1cc(C(=O)Nc2cc(C(F)(F)F)ccn2)c(F)cc1-c1nc([C@@H]2CC[C@H]3CCC(=O)N3C2)n2ccnc(N)c12 CHEMBL4114626 IC50 0.75 nM
C#CCCOc1cc(C(=O)Nc2cc(C(F)(F)F)ccn2)ccc1-c1nc([C@@H]2CC[C@H]3CCC(=O)N3C2)n2ccnc(N)c12 CHEMBL4115363 IC50 0.75 nM
C[C@H]1CC(=O)N2C[C@H](c3nc(-c4ccc(C(=O)Nc5cc(C(F)(F)F)ccn5)cc4)c4c(N)nccn34)CC[C@H]12 CHEMBL3923011 IC50 0.77 nM
CN(C)C/C=C/C(=O)N1CCc2[nH]c3c(C(N)=O)c(-c4ccc(Oc5ccccc5)cc4)nn3c2CC1 CHEMBL3897574 IC50 0.78 nM
CCOc1cc(C(=O)Nc2cc(C3CC3)ccn2)c(F)cc1-c1nc([C@@H]2CC[C@H]3CCC(=O)N3C2)n2c(Cl)cnc(N)c12 CHEMBL4113827 IC50 0.78 nM
C=CC(=O)NCCOc1cccc(Nc2cc(-c3ccnc(N4CCn5c(cc6c5CC(C)(C)C6)C4=O)c3CO)cn(C)c2=O)n1 CHEMBL3913800 Ki 0.792 nM
CN1CCN(C2CCC(n3cc(-c4ccc(Oc5ccccc5)cc4)c4c(N)ncnc43)CC2)CC1 CHEMBL1997617 pKi 0.7943 nM
Nc1nccn2c([C@@H]3CC[C@H](C(=O)O)C3)nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3)c12 CHEMBL4101367 IC50 0.8 nM
C[C@H]1CN(C2COC2)CCN1c1cnc(Nc2cc(-c3ccnc(N4CCn5c(cc6c5CC(C)(C)C6)C4=O)c3CO)cn(C)c2=O)cn1 CHEMBL4070991 Ki 0.8 nM
Nc1nccn2c([C@@H]3CCCN(C4CCOCC4)C3)nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3F)c12 CHEMBL4077588 IC50 0.8 nM
CC(=O)c1cc(Nc2nc(N)cc(-c3cccc(-n4ccc5cc(C6CC6)cc(F)c5c4=O)c3CO)n2)cn1C CHEMBL4202615 IC50 0.8 nM
C=CC(=O)N[C@@H]1Cn2c(c(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3)c3c(N)ncnc32)C1=C CHEMBL4202814 IC50 0.8 nM
C=CC(=O)Nc1cccc(Nc2nc(Nc3ccc(OCC(=O)N4CCOCC4)c(Cl)c3)ncc2Cl)c1 CHEMBL4286900 IC50 0.8 nM
C=CC(=O)Nc1cccc(Nc2nc(Nc3ccc(OC)c(OCCCN4CCOCC4)c3)ncc2Cl)c1 CHEMBL4289281 IC50 0.8 nM
C=CC(=O)N[C@H]1CCN(c2ccc(C(N)=O)c(Nc3ccc(N4CCC(F)(F)CC4)cc3)n2)C1 CHEMBL4288997 IC50 0.8 nM
C=CS(=O)(=O)N1CCC(CNc2ncnc(N)c2-c2ccc(Oc3ccccc3)cc2)CC1 CHEMBL4459438 IC50 0.8 nM
C=CC(=O)Nc1cccc(-n2c(=O)n(C(C)C)c(=O)c3cnc(Nc4ccc(N5CCN(C)CC5)c(C)c4)nc32)c1 CHEMBL4126630 IC50 0.8 nM
O=C(C#CCCN1CCOCC1)Nc1ccc2nccc(Oc3ccc(C(=O)Nc4ccccn4)cc3)c2c1 CHEMBL4792062 IC50 0.8 nM
Cn1cc(Nc2nccc(-c3ccc4c(c3)CCNC[C@H]4NC(=O)c3cn(C(C)(C)C)nn3)n2)cn1 CHEMBL5081318 IC50 0.8 nM
CN1CC[C@@H](NC(=O)c2cn(C(C)(C)C)nn2)c2ccc(-c3ccnc(Nc4cnn(C)c4)n3)cc2C1 CHEMBL5094998 IC50 0.8 nM
C=CC(=O)Nc1cccc(-n2c(=O)c(C3CCCCC3)nc3cnc(Nc4cccc(OCC(C)=O)c4)nc32)c1 CHEMBL5080260 IC50 0.8 nM
C[C@@H]1CN(C(C)(C)/C=C(\C#N)C(=O)N2CCC[C@@H](n3nc(-c4ccc(Oc5ccccc5)cc4F)c4c(N)ncnc43)C2)C[C@H](C)N1C CHEMBL5195816 IC50 0.8 nM
C=CC(=O)N1CCC(CNc2ncnc3[nH]cc(C(=O)N4CC(Oc5cccc6ccccc56)C4)c23)CC1 CHEMBL5204458 IC50 0.8 nM
C=CC(=O)N1CCC(CNc2ncnc3[nH]cc(C(=O)N4CC(Oc5ccccn5)C4)c23)CC1 CHEMBL5170025 IC50 0.8 nM
CC#CC(=O)N1CC=C(c2c[nH]c3ncnc(-c4ccc(CNC(=O)c5ccc(C(C)(C)C)cc5)c(F)c4)c23)CC1 CHEMBL5196932 IC50 0.8 nM
C=CC(=O)N1CCC(c2c[nH]c3ncnc(-c4ccc(CNC(=O)c5ccc(C(C)(C)C)cc5)c(C)c4)c23)CC1 CHEMBL5176551 IC50 0.8 nM
C=CC(=O)N1CC=C(c2c[nH]c3ncnc(-c4ccc(CNC(=O)Nc5ccccc5)c(F)c4)c23)CC1 CHEMBL5177044 IC50 0.8 nM
C=CC(=O)N1CCC(C2CCNc3c(C(N)=O)c(-c4ccc(Oc5ccccc5)c(Cl)c4)nn32)CC1 CHEMBL3902845 IC50 0.8 nM
COc1cccc2c(=O)n(-c3cccc(-c4c(Cl)cc(C(N)=O)c5[nH]c6cc(C(C)(C)O)ccc6c45)c3C)c(=O)n(C)c12 CHEMBL3895530 IC50 0.81 nM
Nc1nccn2c([C@H]3CCn4c(nnc4C(F)(F)F)C3)nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3)c12 CHEMBL3941392 IC50 0.81 nM
Cc1cnc(NC(=O)c2ccc(-c3nc([C@@H]4CC[C@H]5CCC(=O)N5C4)n4c(Cl)cnc(N)c34)cc2)s1 CHEMBL4110295 IC50 0.81 nM
Nc1nc(Nc2ccc(N3CCOCC3)cc2)nc(-c2cccc(NC(=O)c3cc4c(s3)CCCC4)c2CO)n1 CHEMBL4213416 IC50 0.81 nM
C=CC(=O)Nc1cccc(Nc2nc(Nc3ccc(OCCCP(=O)(OCC)N4CCOCC4)cc3)ncc2Cl)c1 CHEMBL3904000 IC50 0.82 nM
Cc1c(NC(=O)/C=C/CN(C)C)cccc1-c1ccc(C(N)=O)c2[nH]c3c(c12)CCC(C(C)(C)O)C3 CHEMBL4238297 IC50 0.82 nM
CC(C)(C)c1ccc2c(=O)n(-c3cccc(-n4cc(C(N)=O)c(Nc5cnccn5)n4)c3CO)ncc2c1 CHEMBL3652665 IC50 0.83 nM
CC#CC(=O)N1CC2(CC(n3nc(-c4ccc(Oc5ccccc5)cc4)c4c(N)ncnc43)C2)C1 CHEMBL3647516 IC50 0.83 nM
C=CC(=O)N(C)CCOc1cncnc1-c1ccc(CN2CCN(CC(C)C)CC2=O)c(C)c1 CHEMBL5197765 IC50 0.83 nM
Cc1c(-c2c(Cl)cc(C(N)=O)c3[nH]c4c(c23)CC[C@H](C(C)(C)O)C4)cccc1-n1c(=O)c2cc(F)cc(F)c2n(C)c1=O CHEMBL3951540 IC50 0.84 nM
COc1cc2nc(Nc3ccccc3C)c3cncn3c2cc1NC(=O)C#CCN1CCOCC1 CHEMBL1916712 IC50 0.847 nM
COc1cc2nc(Nc3ccccc3C)c3cncn3c2cc1NC(=O)C#CCN1CCCCC1 CHEMBL1916713 IC50 0.847 nM
C=CC(=O)N1CC2(CC(n3nc(-c4ccc(-c5cnc(Cc6ccccc6)n(C)c5=O)cc4F)c4c(N)ncnc43)C2)C1 CHEMBL3647519 IC50 0.85 nM
CC(C)(F)c1ccnc(NC(=O)c2ccc(-c3nc([C@@H]4CC[C@H]5CCC(=O)N5C4)n4ccnc(N)c34)cc2)c1 CHEMBL4112427 IC50 0.85 nM
C#CC(=O)N1CCC(Nc2ccc(C(N)=O)c3[nH]c(C)c(C)c23)CC1 CHEMBL4646648 IC50 0.85 nM
Nc1nc(-c2cccc(-n3ccc4cc(C5CC5)cc(F)c4c3=O)c2CO)c2cc(C3=CCN(C4COC4)CC3)[nH]c2n1 CHEMBL5077961 IC50 0.85 nM
N#Cc1cc(Nc2nc(N)nc(-c3cccc(-n4ccc5cc(C6CC6)cc(F)c5c4=O)c3CO)n2)cn1C1CC1 CHEMBL4203192 IC50 0.86 nM
Cc1c(-c2ccc(C(N)=O)c3[nH]c4cc(C(C)(C)O)ccc4c23)cccc1-n1c(=O)cc2c(F)cccn2c1=O CHEMBL4743497 IC50 0.86 nM
CC1(C(=O)N2C[C@H](c3nc(-c4ccc(C(=O)Nc5cc(C(F)(F)F)ccn5)cc4)c4c(N)nccn34)CC[C@@H]2C(F)F)COC1 CHEMBL4778161 IC50 0.86 nM
C[C@H]1CN(C(=O)c2cccc3c2C(=O)N(C2CCC(=O)NC2=O)C3=O)CCN1c1ccc(Nc2cc(-c3ccnc(N4CCn5c(cc6c5CC(C)(C)C6)C4=O)c3CO)cn(C)c2=O)nc1 CHEMBL5403472 Kd 0.86 nM
Cn1cc(-c2ccnc(N3CCn4c(cc5c4CC(C)(C)C5)C3=O)c2CO)cc(Nc2ccnc(N3CCC(C(=O)NCC#N)C3)n2)c1=O CHEMBL3986379 Ki 0.864 nM
Cn1cc(-c2cccc(N3CCc4c(sc5c4CCCC5)C3=O)c2CO)cc(Nc2ccncn2)c1=O CHEMBL3670081 IC50 0.87 nM
C=CC(=O)N1CCC2(CC(n3nc(-c4ccc(Oc5ccccc5)cc4)c4c(N)ncnc43)C2)C1 CHEMBL3647518 IC50 0.87 nM
COc1cc2nc(Nc3ccccc3C)c3cncn3c2cc1NC(=O)/C=C/CN(C)C CHEMBL1916715 IC50 0.884 nM
C=CC(=O)N[C@H]1CCCN(c2cccc(Nc3cc(-c4ccnc(N5CCn6c(cc7c6CC(C)(C)C7)C5=O)c4CO)cn(C)c3=O)n2)C1 CHEMBL3911251 Ki 0.888 nM
Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)nn2[C@@H]1CCCN(C(=O)/C=C/CN2CCOCC2)C1 CHEMBL4110614 IC50 0.89 nM
Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)nn2[C@H]1CCCN(C(=O)/C=C/CN2CCOCC2)C1 CHEMBL3968716 IC50 0.89 nM
C=CC(=O)NCC1(C)CCNc2c(C(N)=O)c(-c3ccc(Oc4ccccc4)cc3)nn21 CHEMBL3901100 IC50 0.89 nM
CC(C)(/C=C(\C#N)C(=O)N1CCC[C@H](n2nc(-c3ccc(Oc4ccccc4)cc3F)c3c(N)ncnc32)C1)N1CC(O)C1 CHEMBL3942079 IC50 0.9 nM
CCN1CCN(C(C)(C)/C=C(\C#N)C(=O)N2CCC[C@H]2Cn2nc(-c3ccc(Oc4ccccc4)cc3F)c3c(N)ncnc32)CC1 CHEMBL3702859 IC50 0.9 nM
CCN(C1COC1)C(C)(C)/C=C(\C#N)C(=O)N1CCC[C@H](n2nc(-c3ccc(Oc4ccccc4)cc3F)c3c(N)ncnc32)C1 CHEMBL3965958 IC50 0.9 nM
CCN1CCN(C(C)(C)/C=C(\C#N)C(=O)N2CCC[C@H](n3nc(-c4ccc(Oc5ccccc5)cc4F)c4c(N)ncnc43)C2)CC1 CHEMBL3903174 IC50 0.9 nM
CC(C)(/C=C(\C#N)C(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4cccc(F)c4F)cc3F)c3c(N)ncnc32)C1)N1CCOCC1 CHEMBL4114774 IC50 0.9 nM
CC(C)(/C=C(\C#N)C(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3F)c3c(N)ncnc32)C1)N1CC(O)C1 CHEMBL3702833 IC50 0.9 nM
CCN(C1COC1)C(C)(C)/C=C(\C#N)C(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3F)c3c(N)ncnc32)C1 CHEMBL3702840 IC50 0.9 nM
CCN1CCN(C(C)(C)/C=C(\C#N)C(=O)N2CCC[C@@H](n3nc(-c4ccc(Oc5ccccc5)cc4F)c4c(N)ncnc43)C2)CC1 CHEMBL3702847 IC50 0.9 nM
Cc1c(-c2c(Cl)cc(C(N)=O)c3[nH]c4c(c23)CC[C@H](C(C)(C)O)C4)cccc1-n1c(=O)c2cccc(F)c2n(C)c1=O CHEMBL3897349 IC50 0.9 nM
Cc1c(-c2c(F)cc(C(N)=O)c3[nH]c4c(c23)CC[C@H](C(C)(C)O)C4)cccc1-n1c(=O)[nH]c2c(F)cccc2c1=O CHEMBL3929953 IC50 0.9 nM
C[C@]1(C(=O)O)CCC[C@@H](c2nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3)c3c(N)nccn23)C1 CHEMBL4063275 IC50 0.9 nM
CC1(C(=O)N2CCO[C@@H](c3nc(-c4ccc(C(=O)Nc5cc(C(F)(F)F)ccn5)cc4)c4c(N)nccn34)C2)COC1 CHEMBL4075605 IC50 0.9 nM
C=CC(=O)N(CC)CCOc1c(N)ncnc1-c1cc(F)cc(NC(=O)c2ccc(C3CC3)cc2F)c1C CHEMBL4439622 IC50 0.9 nM
C=CC(=O)N1CC=C(c2c[nH]c3ncnc(-c4cc(F)cc(NC(=O)c5ccc(C6CC6)cc5)c4C)c23)CC1 CHEMBL4593663 IC50 0.9 nM
Cc1nn(C2CCOCC2)cc1-c1nc2c(-c3ccc4c(c3)CCC[C@@H]4NC(=O)c3nc(C(C)(C)C)no3)ccnc2[nH]1 CHEMBL4872092 IC50 0.9 nM
CN(C)C(C)(C)/C=C(\C#N)C(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3F)c3c(N)ncnc32)C1 CHEMBL5178314 IC50 0.9 nM
C=CC(=O)N1CCC[C@H](n2nc(-c3ccc(Oc4ccccc4)cc3C)c3c(N)ncnc32)C1 CHEMBL5271284 IC50 0.9 nM
C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(NC(=O)c4ccc(F)cc4)c4c3OCO4)c3c(N)ncnc32)C1 CHEMBL5417273 IC50 0.9 nM
C=CC(=O)Nc1cccc(Nc2nc(Nc3ccc(N4CCOCC4)cc3)ncc2[S+](C)[O-])c1 CHEMBL3785165 IC50 0.903 nM
COc1cccn2c(=O)n(-c3cccc(-c4c(Cl)cc(C(N)=O)c5[nH]c6cc(C(C)(C)O)ccc6c45)c3C)c(=O)cc12 CHEMBL3891767 IC50 0.91 nM
COCC#CC(=O)N1CCC([C@@H]2CCNc3c(C(N)=O)c(-c4ccc(Oc5ccccc5)cc4)nn32)CC1 CHEMBL3969976 IC50 0.91 nM
C=CC(=O)NCCOc1cccc(Nc2cc(-c3ccnc(-n4ncc5cc(C(C)(C)C)cc(F)c5c4=O)c3CO)cn(C)c2=O)n1 CHEMBL3954850 Ki 0.915 nM
CN(C)C/C=C/C(=O)N1CCCC1Cn1nc(-c2ccc(Oc3ccccc3)cc2)c2c(N)ncnc21 CHEMBL3903870 IC50 0.92 nM
Cc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)nn2C[C@H]1CCCN1C(=O)/C=C/CN(C)C CHEMBL4107818 IC50 0.92 nM
C=CC(=O)Nc1cccc(Nc2nc(Nc3ccc(NS(=O)(=O)c4ccc(OC)cc4)cc3)ncc2F)c1 CHEMBL4070521 IC50 0.92 nM
CN1CCN([C@H]2CC[C@H](n3nc(-c4ccc(Oc5ccccc5)cc4)c4c(N)ncnc43)CC2)CC1 CHEMBL44577 IC50 0.92 nM
Nc1nccn2c([C@H]3CC[C@H]4C[C@@H](O)C(=O)N4C3)nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3)c12 CHEMBL3939080 IC50 0.93 nM
Cn1nc(NC(=O)c2ccc(-c3nc([C@@H]4CC[C@H]5CCC(=O)N5C4)n4ccnc(N)c34)cc2)cc1C1CC1 CHEMBL4113593 IC50 0.93 nM
C=CC(=O)N1CC[C@]2(C1)C[C@H](n1c(NC(=O)c3ccc(-c4cnco4)s3)nc3ccccc31)C2 CHEMBL4211372 IC50 0.94 nM
CC(C)(C)c1ccc2c(=O)n(-c3cccc(-n4cc(C(N)=O)c(Nc5ccccn5)n4)c3CO)ncc2c1 CHEMBL3652681 IC50 0.95 nM
C=CC(=O)N1CC[C@]2(C1)C[C@H](n1c(NC(=O)c3ccc(C(F)F)s3)nc3cc(CNCC(C)(C)CO)ccc31)C2 CHEMBL4202941 IC50 0.95 nM
C=CC(=O)Nc1ccccc1C1CCNc2c(C(N)=O)c(-c3cccc(Cl)c3)nn21 CHEMBL3951926 IC50 0.96 nM
CC[C@H]1CN(C2COC2)CCN1c1ccc(Nc2cc(-c3ccnc(N4CCn5c(cc6c5CC(C)(C)C6)C4=O)c3CO)cn(C)c2=O)nc1 CHEMBL4087543 Ki 0.96 nM
COCC#CC(=O)Nc1cc2c(Oc3ccc(C(=O)Nc4ccccn4)cc3)ccnc2cc1OC CHEMBL4794213 IC50 0.96 nM
C=CC(=O)N1CCC(C2CCNc3c(C(N)=O)c(-c4cc(OC)c(CCC)c(OC)c4)nn32)CC1 CHEMBL5271932 IC50 0.97 nM
Cc1cc(-c2nc([C@@H]3CC[C@H]4CCC(=O)N4C3)n3ccnc(N)c23)ccc1C(=O)Nc1cc(C#N)ccn1 CHEMBL4111181 IC50 0.98 nM
COc1cc(-c2nc([C@@H]3CCCN(C(=O)C4(C)COC4)C3)n3ccnc(N)c23)ccc1C(=O)Nc1cc(C(F)(F)F)ccn1 CHEMBL4751902 IC50 0.98 nM
C=CC(=O)N(C)CCOc1cncnc1-c1ccc(CN2CCN(CC3(C)CC3)CC2=O)c(C)c1 CHEMBL5186635 IC50 0.98 nM
CCOc1cc(C(=O)Nc2cc(C(F)(F)F)ccn2)ccc1-c1nc([C@@H]2CC[C@H]3CCC(=O)N3C2)n2c(F)cnc(N)c12 CHEMBL4113487 IC50 0.99 nM
Nc1n[nH]c2cc(-c3ccc(C(=O)O)cc3)nc(-c3ccc(Oc4ccccc4)cc3)c12 CHEMBL2057923 IC50 1.0 nM
C=CC(=O)Nc1cccc(Nc2nc(Nc3ccc(Oc4ccnc(C(=O)NC)c4)cc3)ncc2F)c1 CHEMBL2216827 IC50 1.0 nM
CN1CCn2nc(Nc3cc(-c4ccc(F)c(NC(=O)c5cc6ccccc6s5)c4F)n[nH]c3=O)cc2C1 CHEMBL3745935 IC50 1.0 nM
C=CC(=O)Nc1cccc(Oc2nc(Nc3ccc(N4CCN(C)CC4)cc3)nc3ccsc23)c1 CHEMBL3786343 IC50 1.0 nM
Cn1cc(-c2cccc(N3CCn4c(cc5c4CCCC5)C3=O)c2CO)cc(Nc2cc(C3CC3)n[nH]2)c1=O CHEMBL3670083 IC50 1.0 nM
CN1CCN(c2ccc(Nc3cc(-c4cc(F)cc(N5CCc6c(sc7c6CCCC7)C5=O)c4CO)cn(C)c3=O)nc2)CC1 CHEMBL3903500 IC50 1.0 nM
Nc1n[nH]c2cc(-c3ccc(C(=O)NCC(=O)O)cc3)nc(-c3ccc(Oc4ccccc4)cc3)c12 CHEMBL3657233 IC50 1.0 nM
Nc1n[nH]c2c(-c3ccccn3)cnc(-c3ccc(Oc4ccccc4)cc3)c12 CHEMBL3657235 IC50 1.0 nM
Nc1n[nH]c2cc(-c3ccc(C(=O)O)c(F)c3)nc(-c3ccc(Oc4ccccc4)cc3)c12 CHEMBL3657240 IC50 1.0 nM
COCCN1CCN(C(C)(C)/C=C(\C#N)C(=O)N2CCC[C@H](n3nc(-c4ccc(Oc5ccccc5)cc4F)c4c(N)ncnc43)C2)CC1 CHEMBL3913230 IC50 1.0 nM
C=CC(=O)N1CC2(CC(n3nc(-c4ccc(Oc5ccccc5)cc4)c4c(N)ncnc43)C2)C1 CHEMBL3647514 IC50 1.0 nM
CC#CC(=O)N1CC2(CC(n3nc(-c4ccc(Oc5ccccc5)cn4)c4c(N)ncnc43)C2)C1 CHEMBL3647525 IC50 1.0 nM
COc1cc(-c2nn(C3CCCN(C(=O)/C(C#N)=C/C4CC4)C3)c3ncnc(N)c23)ccc1Oc1ccc(Cl)c(Cl)c1 CHEMBL4114799 IC50 1.0 nM
CC(C)C(C)(C)/C=C(\C#N)C(=O)N1CCC[C@@H]1Cn1cc(-c2ccc(Oc3ccccc3)cc2)c2c(N)ncnc21 CHEMBL4114748 IC50 1.0 nM
Cc1c(NC(=O)c2ccc(C3(F)CC3)cc2)cc(F)cc1-c1ncnc2[nH]c(C3=CCN(C(=O)N(C)C)CC3)cc12 CHEMBL3946923 IC50 1.0 nM
CN(C)C(=O)N1CC=C(c2cc3c(-c4cccc(NC(=O)c5ccc(C6CC6)cc5)c4CO)ncnc3[nH]2)CC1 CHEMBL3919346 IC50 1.0 nM
CN1CCN(Cc2ccc(-c3cc4c(-c5cccc(N6CCOc7cc(C8CC8)cc(F)c7C6=O)c5CO)ccnc4[nH]3)nc2)CC1 CHEMBL3928203 IC50 1.0 nM
O=C(N1CC=C(c2cc3c(-c4cccc(N5CCOc6cc(C7CC7)cc(F)c6C5=O)c4CO)ccnc3[nH]2)CC1)N1CCC1 CHEMBL3957396 IC50 1.0 nM
CN(C)C(=O)N1CC=C(c2cc3c(-c4cccc(N5CCOc6cc(C7CC7)cc(F)c6C5=O)c4CO)ccnc3[nH]2)CC1 CHEMBL3936823 IC50 1.0 nM
CC1(O)CN(C(=O)N2CC=C(c3cc4c(-c5cccc(N6CCOc7cc(C8CC8)cc(F)c7C6=O)c5CO)ccnc4[nH]3)CC2)C1 CHEMBL3982806 IC50 1.0 nM
O=C(CO)N1CC=C(c2cc3c(-c4cccc(N5CCOc6cc(C7CC7)cc(F)c6C5=O)c4CO)ccnc3[nH]2)CC1 CHEMBL3967939 IC50 1.0 nM
COCCN1CCN(C(C)(C)/C=C(\C#N)C(=O)N2CCC[C@@H](n3nc(-c4ccc(Oc5ccccc5)cc4F)c4c(N)ncnc43)C2)CC1 CHEMBL3702850 IC50 1.0 nM
Cc1c(-c2c(Cl)cc(C(N)=O)c3[nH]c4cc(C(C)(C)O)ccc4c23)cccc1-n1c(=O)c2ccccc2n(C)c1=O CHEMBL3974859 IC50 1.0 nM
C=CC(=O)N1CCC2C(CNc3c(C(N)=O)c(-c4ccc(Oc5ccccc5)cc4)nn32)C1 CHEMBL3962583 IC50 1.0 nM
C=CC(=O)N1C[C@H]2CNc3c(C(N)=O)c(-c4ccc(Oc5ccccc5)cc4)nn3[C@H]2C1 CHEMBL4115303 IC50 1.0 nM
C=CC(=O)N1CCC(C2(C)CCNc3c(C(N)=O)c(-c4ccc(Oc5ccccc5)cc4)nn32)CC1 CHEMBL3916090 IC50 1.0 nM
C=CC(=O)Nc1ccccc1C1CCNc2c(C(N)=O)c(-c3ccc(F)c(OC)c3)nn21 CHEMBL3945450 IC50 1.0 nM
C[C@]1(C(=O)O)CC[C@@](C)(c2nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3)c3c(N)nccn32)CC1 CHEMBL4079697 IC50 1.0 nM
CC1C=C(c2ccnc(N3Cc4cc(C(C)(C)C)sc4C3=O)c2CO)C=C(Nc2ccc(N3CCN(C4COC4)CC3)cc2)C1=O CHEMBL4093188 Ki 1.0 nM
COCCCN1CCN(c2ccc(Nc3cc(-c4ccnc(N5CCn6c(cc7c6CC(C)(C)C7)C5=O)c4CO)cn(C)c3=O)nc2)CC1 CHEMBL4097832 Ki 1.0 nM
C=CC(=O)Nc1cccc(Nc2nc(Nc3ccc(OCC(=O)N4CCOCC4)cc3)ncc2Cl)c1 CHEMBL4289688 IC50 1.0 nM
O=C(Nc1cccc([C@@H]2CN(c3ncnc4[nH]ccc34)CCN2CCO)c1)Nc1c(F)cccc1N1CCCC1 CHEMBL4564973 IC50 1.0 nM
C=CC(=O)Nc1ccccc1C1CCNc2c(C(N)=O)c(-c3ccc(OC)cc3)nn21 CHEMBL3926191 IC50 1.0 nM
C=CC(=O)N1CCC(c2c[nH]c3ncnc(-c4cc(F)cc(NC(=O)c5ccc(C6CC6)cc5)c4C)c23)CC1 CHEMBL4739958 IC50 1.0 nM
CC#CC(=O)Nc1cc2c(Oc3ccc(C(=O)Nc4ccccn4)cc3)ccnc2cc1OCCCN1CCN(C)CC1 CHEMBL4756092 IC50 1.0 nM
Cn1cc(-c2nc3c(-c4ccc(CNC(=O)N5CC(OC(C)(C)C)C5)c(F)c4)ccnc3[nH]2)cn1 CHEMBL4846816 IC50 1.0 nM
Cc1c(-c2nc3c(-c4ccc5c(c4)CCC[C@@H]5NC(=O)c4nc(C(C)(C)C)no4)ccnc3[nH]2)cnn1C(C)C CHEMBL4857459 IC50 1.0 nM
Cc1c(NC(=O)c2cc3c(s2)CCCC3)cccc1-c1cn(C)c(=O)c(Nc2ccc(C3CN(C)CC(=O)N3C)cc2)n1 CHEMBL5069979 IC50 1.0 nM
C=CC(=O)Nc1cccc(Oc2nc(Nc3ccc(N4CCN(C)CC4)cc3)nc3ccoc23)c1 CHEMBL4163691 IC50 1.0 nM
O=C([C@H](Nc1cc(F)cc(Cl)c1)C1CC1)N1CC[C@@H]2CCN(c3ncnc4[nH]ncc34)C[C@@H]21 CHEMBL5176609 IC50 1.0 nM
Cn1cc(-c2cccc(-n3ncc4cc(C(C)(C)C)cc(F)c4c3=O)c2CO)cc(Nc2ccc(C(=O)N3CCOCC3)cn2)c1=O CHEMBL4116419 IC50 1.0 nM
CC#CC(=O)N1CC=C(c2c[nH]c3ncnc(-c4ccc(CNC(=O)c5ccccc5)c(F)c4)c23)CC1 CHEMBL5198455 IC50 1.0 nM
Cc1cc(-c2ccnc(Nc3cnn(C)c3)n2)ccc1CN1CCN(CC(C)(C)C)CC1=O CHEMBL5188545 IC50 1.0 nM
CC(C)CN1CCN(Cc2ccc(-c3ccnc(Nc4cnn(CCO)c4)n3)cc2C(F)(F)F)C(=O)C1 CHEMBL5200748 IC50 1.0 nM
Cc1cc(-c2ccnc(Nc3cnn(CCO)c3)n2)ccc1CN1CCN(CC(C)(C)C)CC1=O CHEMBL5189116 IC50 1.0 nM
C=CC(=O)N1CC2CC(n3nc(-c4ccc(C(=O)Nc5ccccn5)cc4)c4c(N)ncnc43)CC2C1 CHEMBL5197549 IC50 1.0 nM
C=CC(=O)Nc1ccccc1C1CCNc2c(C(N)=O)c(-c3cc(OC)c(C4CC4)c(OC)c3)nn21 CHEMBL5272404 IC50 1.0 nM
C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(NC(=O)c4cccc(N(C)C)c4)c4c3OCO4)c3c(N)ncnc32)C1 CHEMBL5415887 IC50 1.02 nM
C=CC(=O)Nc1cccc(Oc2nc(Nc3ccc(NS(=O)(=O)c4ccc(C)cc4)c(C)c3)ncc2Cl)c1 CHEMBL4092347 IC50 1.05 nM
C=CC(=O)Nc1cccc(Nc2nc(Nc3ccc(N4CCOCC4)cc3)ncc2SC)c1 CHEMBL3787615 IC50 1.08 nM
C=CC(=O)N1CC[C@]2(C1)C[C@H](n1c(NC(=O)c3ccc(-c4cnco4)s3)nc3cc(F)ccc31)C2 CHEMBL4208358 IC50 1.09 nM
CC#CC(=O)N1CC2(CC(n3nc(-c4ccc(Oc5ccccc5)nc4)c4c(N)ncnc43)C2)C1 CHEMBL3647520 IC50 1.1 nM
CN(C)C/C=C/C(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1 CHEMBL3647970 IC50 1.1 nM
COc1ccc2c(=O)n(-c3cccc(-c4c(Cl)cc(C(N)=O)c5[nH]c6cc(C(C)(C)O)ccc6c45)c3C)c(=O)n(C)c2c1 CHEMBL3939795 IC50 1.1 nM
Nc1ncnc2c1c(-c1ccc(C(=O)Nc3cc(C(F)(F)F)ccn3)cc1)nn2[C@@H]1CCCc2c1cnn2CCO CHEMBL4113220 IC50 1.1 nM
C=CC(=O)N(C)CC1CCNc2c(C(N)=O)c(-c3ccc(Oc4ccccc4)cc3)nn21 CHEMBL3916950 IC50 1.1 nM
CN(C)C/C=C/C(=O)Nc1ccccc1C1CCNc2c(C(N)=O)c(-c3ccc(Oc4ccccc4)cc3)nn21 CHEMBL3913669 IC50 1.1 nM
C=CC(=O)Nc1cc(C2CCNc3c(C(N)=O)c(-c4ccc(Oc5ccccc5)cc4)nn32)ccc1Cl CHEMBL3889791 IC50 1.1 nM
C=CC(=O)N1CCCC1C1CCNc2c(C(N)=O)c(-c3ccc(Oc4ccccc4)cc3)nn21 CHEMBL3895268 IC50 1.1 nM
C=CC(=O)N1CCC(C2CCNc3c(C(N)=O)c(-c4ccc(Oc5ccccc5)c(OC)c4)nn32)CC1 CHEMBL3927293 IC50 1.1 nM
CCC#CC(=O)N1CCC([C@@H]2CCNc3c(C(N)=O)c(-c4ccc(Oc5ccccc5)cc4)nn32)CC1 CHEMBL3894235 IC50 1.1 nM
CN(C)CC#CC(=O)N1CCC([C@@H]2CCNc3c(C(N)=O)c(-c4ccc(Oc5ccccc5)cc4)nn32)CC1 CHEMBL3983090 IC50 1.1 nM
C=CC(=O)Nc1ccccc1C1CCNc2c(C(N)=O)c(-c3ccc(F)c(Cl)c3)nn21 CHEMBL3912667 IC50 1.1 nM
Nc1nccn2c([C@@H]3CC[C@H]4CCC(=O)N4C3)nc(-c3ccc(C(=O)Nc4cc(C5CC5)ccn4)c(F)c3)c12 CHEMBL4108885 IC50 1.1 nM
COc1cc(C(=O)Nc2cc(C#N)ccn2)ccc1-c1nc([C@@H]2CC[C@H]3CCC(=O)N3C2)n2ccnc(N)c12 CHEMBL4110803 IC50 1.1 nM
Nc1nccn2c([C@@H]3CC[C@H]4CCC(=O)N4C3)nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3OCCO)c12 CHEMBL4115000 IC50 1.1 nM
CC(C)[C@]1(C(=O)O)CC[C@@H](c2nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3)c3c(N)nccn23)C1 CHEMBL4066216 IC50 1.1 nM
C=CC(=O)Nc1cccc(-c2ccc(C(N)=O)c3[nH]ccc23)c1C CHEMBL4248834 IC50 1.1 nM
C=CC(=O)N(C)c1cccc(-c2ccc(C(N)=O)c3[nH]c4c(c23)CCC(C(C)(C)O)C4)c1C CHEMBL4239031 IC50 1.1 nM
C=CC(=O)N[C@H]1CCN(c2ncc(C(N)=O)c(Nc3ccc(C(=O)N4CC(C)OC(C)C4)cc3)n2)C1 CHEMBL4277754 IC50 1.1 nM
COc1cc(C(=O)Nc2cc(C(F)(F)F)ccn2)ccc1-c1nc([C@@H]2CCCN(C(=O)C3(C)COC3)C2)n2ccnc(N)c12 CHEMBL4747860 IC50 1.1 nM
Cn1cc(-c2nc3c(-c4ccc5c(c4)CCC[C@H]5NC(=O)c4nc(C(C)(C)C)no4)ccnc3[nH]2)cn1 CHEMBL4859888 IC50 1.1 nM
Cc1nn(C(C)C)cc1-c1nc2c(-c3ccc4c(c3)CCC[C@@H]4NC(=O)c3nc(C(C)(C)C)no3)ccnc2[nH]1 CHEMBL4851951 IC50 1.1 nM
Cc1c(CNC(=O)N2CC(OC(C)C)C2)ccc(-c2ccnc(Nc3cnn(C)c3)n2)c1F CHEMBL5087083 IC50 1.1 nM
C[C@@H]1CN(C(C)(C)/C=C(\C#N)C(=O)N2CCC[C@@H](n3nc(-c4ccc(Oc5ccccc5)cc4F)c4c(N)ncnc43)C2)C[C@H](C)N1 CHEMBL5207901 IC50 1.1 nM
CC#CC(=O)N1CC=C(c2c[nH]c3ncnc(-c4ccc(CNC(=O)c5ccc(C(C)(C)C)cc5)c(C)c4)c23)CC1 CHEMBL5170833 IC50 1.1 nM
Nc1nccn2c([C@H]3CC[C@H]4CCC(=O)N4C3)nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3OCCO)c12 CHEMBL5175002 IC50 1.1 nM
NC(=O)[C@H]1CCN(c2ncnc(N)c2F)C[C@@H]1N1CCC[C@@H](Nc2cc(Cl)cc(C(F)(F)F)c2)C1=O CHEMBL4297640 IC50 1.1 nM
C=CC(=O)N1CCC(C2CCNc3c(C(N)=O)c(-c4cc(OC)c(Br)c(OC)c4)nn32)CC1 CHEMBL5286702 IC50 1.1 nM
C=CC(=O)N1CCC([C@@H]2CCNc3c(C(N)=O)c(-c4cc(OC)c(C)c(OC)c4)nn32)CC1 CHEMBL5276374 IC50 1.1 nM
Cc1ccc(Nc2nn(-c3cccc(-n4ncc5cc(C(C)(C)C)ccc5c4=O)c3CO)cc2C(N)=O)nc1 CHEMBL3652666 IC50 1.13 nM
O=C1c2c(F)cc(C3CC3)cc2OCCN1c1cc(F)cc(-c2ccnc3[nH]c(-c4ccc(OC5CCN(C6COC6)CC5)cn4)cc23)c1CO CHEMBL3918358 IC50 1.15 nM
C=CC(=O)Nc1cccc(Nc2nc(Nc3ccc(OCCSC(=S)NCc4cccnc4)cc3)ncc2F)c1 CHEMBL4461112 IC50 1.15 nM
C=CC(=O)Nc1cccc(Nc2nc(Nc3ccc(NS(=O)(=O)c4ccc(F)cc4)c(OC)c3)ncc2Cl)c1 CHEMBL4065460 IC50 1.18 nM
Cc1c(-c2c(Cl)cc(C(N)=O)c3[nH]c4cc(C(C)(C)O)ccc4c23)cccc1-n1c(=O)[nH]c2c(F)cccc2c1=O CHEMBL3936156 IC50 1.2 nM
CN1CCN(C(C)(C)/C=C(\C#N)C(=O)N2CCC[C@H](n3nc(-c4ccc(Oc5ccccc5)cc4F)c4c(N)ncnc43)C2)CC1=O CHEMBL3979968 IC50 1.2 nM
O=C(CN1CC=C(c2cc3c(-c4cccc(N5CCOc6cc(C7CC7)cc(F)c6C5=O)c4CO)ccnc3[nH]2)CC1)N1CCC1 CHEMBL3952971 IC50 1.2 nM
N#CCC(=O)N1CC=C(c2cc3c(-c4cccc(N5CCOc6cc(C7CC7)ccc6C5=O)c4CO)ccnc3[nH]2)CC1 CHEMBL3943034 IC50 1.2 nM
CN1CCN(C(C)(C)/C=C(\C#N)C(=O)N2CCC[C@@H](n3nc(-c4ccc(Oc5ccccc5)cc4F)c4c(N)ncnc43)C2)CC1=O CHEMBL3702851 IC50 1.2 nM
C=CC(=O)Nc1ccccc1[C@H]1CCNc2c(C(N)=O)c(-c3ccc(OCC4CC4)cc3)nn21 CHEMBL4110931 IC50 1.2 nM
C=CC(=O)Nc1ccccc1C1CCNc2c(C(N)=O)c(-c3ccc(F)c(Br)c3)nn21 CHEMBL3975936 IC50 1.2 nM
C=CC(=O)Nc1ccccc1C1CCNc2c(C(N)=O)c(-c3ccc(Cl)c(F)c3)nn21 CHEMBL3983966 IC50 1.2 nM
C=CC(=O)N1CC(C2(C)CCNc3c(C(N)=O)c(-c4ccc(Oc5ccccc5)cc4)nn32)C1 CHEMBL3894703 IC50 1.2 nM
C=CC(=O)N1CCC(C2CCNc3c(C(N)=O)c(-c4ccc(Oc5ccc(F)cc5F)cc4)nn32)CC1 CHEMBL3935034 IC50 1.2 nM
Nc1nccn2c([C@@H]3CC[C@H]4CCC(=O)N4C3)nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)cnn4)cc3)c12 CHEMBL4113482 IC50 1.2 nM
COc1cc(C(=O)Nc2cc(C(F)(F)F)ccn2)c(F)cc1-c1nc([C@@H]2CC[C@H]3CCC(=O)N3C2)n2c(Cl)cnc(N)c12 CHEMBL4111899 IC50 1.2 nM
CCOc1cc(C(=O)Nc2cc(C(F)(F)F)n(C)n2)ccc1-c1nc([C@@H]2CC[C@H]3CCC(=O)N3C2)n2c(C)cnc(N)c12 CHEMBL4114832 IC50 1.2 nM
CS(=O)(=O)NC(=O)[C@H]1CCC[C@@H](c2nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3)c3c(N)nccn23)C1 CHEMBL4105560 IC50 1.2 nM
Nc1nccn2c1c(-c1ccc(C(=O)Nc3cc(C(F)(F)F)ccn3)cc1)nc2[C@H]1CC[C@H](C(=O)O)CC1 CHEMBL4097968 IC50 1.2 nM
COCCN1CCN(c2ccc(Nc3cc(-c4ccnc(N5CCn6c(cc7c6CC(C)(C)C7)C5=O)c4CO)cn(C)c3=O)nc2)CC1 CHEMBL4062634 Ki 1.2 nM
CC1(C(=O)N2CC[C@@H](c3nc(-c4ccc(C(=O)Nc5cc(C(F)(F)F)ccn5)cc4)c4c(N)nccn34)C2)COC1 CHEMBL4104254 IC50 1.2 nM
N#CCC(=O)N1CC=C(c2cc3c(-c4cccc(N5CCOc6cc(C7CC7)cc(F)c6C5=O)c4CO)ccnc3[nH]2)CC1 CHEMBL4216939 IC50 1.2 nM
C=CC(=O)Nc1cccc(-c2ccc(C(N)=O)c3[nH]cc(C)c23)c1C CHEMBL4245037 IC50 1.2 nM
C/C=C/C(=O)Nc1cccc(-c2ccc(C(N)=O)c3[nH]c4cc(C(C)(C)O)ccc4c23)c1C CHEMBL4246005 IC50 1.2 nM
C=CC(=O)Nc1cccc(-n2c(=O)n(C(C)C)c(=O)c3cnc(Nc4ccc(N5CCN(C)CC5)c(OC)c4)nc32)c1 CHEMBL4125940 IC50 1.2 nM
C=CC(=O)Nc1ccccc1C1CCNc2c(C(N)=O)c(-c3ccc(OCC4CC4)cc3)nn21 CHEMBL3917026 IC50 1.2 nM
C=CS(=O)(=O)N[C@@H]1CCCN(c2ccc(C(N)=O)c3[nH]c(C)c(C)c23)C1 CHEMBL4641586 IC50 1.2 nM
C=CC(=O)N(C)C(=O)Cc1c[nH]c2ncnc(-c3cc(F)cc(NC(=O)c4ccc(C5CC5)cc4)c3C)c12 CHEMBL4795673 IC50 1.2 nM
Cc1ccnc(NC(=O)c2ccc(-c3nc([C@@H]4CCCN(C(=O)C5(C)COC5)C4)n4ccnc(N)c34)c(F)c2)c1 CHEMBL4796764 IC50 1.2 nM
C=CC(=O)Nc1ccc2nccc(Oc3ccc(C(=O)Nc4cc(CC)ccn4)cc3)c2c1 CHEMBL4752700 IC50 1.2 nM
COc1ccnc(-c2nc3c(-c4ccc(CNC(=O)c5nc(C(C)(C)C)no5)c(F)c4)ccnc3[nH]2)c1 CHEMBL4852395 IC50 1.2 nM
CC(C)(C)c1noc(C(=O)NC2CCCc3cc(-c4ccnc5[nH]c(-c6cnn(C7CCOCC7)c6)nc45)ccc32)n1 CHEMBL4848010 IC50 1.2 nM
CC(C)OC1CN(C(=O)NCc2ccc(-c3ccnc(Nc4cnn(C)c4)n3)cc2Cl)C1 CHEMBL5086077 IC50 1.2 nM
Cn1cc(Nc2nccc(-c3ccc4c(c3)CCCCC4NC(=O)c3nnc(C(C)(C)C)s3)n2)cn1 CHEMBL5083399 IC50 1.2 nM
Cn1cc(Nc2nccc(-c3ccc4c(c3)CNCC[C@H]4NC(=O)c3cn(C(C)(C)C)nn3)n2)cn1 CHEMBL5075191 IC50 1.2 nM
C=CC(=O)Nc1cccc(-n2c(=O)c(C)nc3cnc(Nc4ccc(OC)cc4)nc32)c1 CHEMBL2437471 IC50 1.2 nM
C=CC(=O)Nc1cccc(-n2c(=O)cnc3cnc(Nc4ccc(N5CCN(C)CC5)cc4)nc32)c1 CHEMBL2437462 IC50 1.2 nM
CC#CC(=O)N1CCC(c2c[nH]c3ncnc(-c4ccc(CNC(=O)c5ccc(C(C)(C)C)cc5)c(F)c4)c23)CC1 CHEMBL5189231 IC50 1.2 nM
C=CC(=O)N1CC=C(c2c[nH]c3ncnc(-c4ccc(CNC(=O)c5ccc(C6CC6)cc5)c(F)c4)c23)CC1 CHEMBL5189426 IC50 1.2 nM
C=CC(=O)N(C)CCOc1cnccc1-c1ccc(CN2CCN(CC3CCC3)CC2=O)c(C)c1 CHEMBL5182804 IC50 1.2 nM
C=CC(=O)N1CCC(C2CCNc3c(C(N)=O)c(-c4cc(Cl)c(Br)c(OC)c4)nn32)CC1 CHEMBL5272121 IC50 1.2 nM
C=CC(=O)N1CCC(C2CCNc3c(C(N)=O)c(-c4cc(OC)c(C(C)C)c(OC)c4)nn32)CC1 CHEMBL5278071 IC50 1.2 nM
CC#CC(=O)N1CCC([C@@H]2CCNc3c(C(N)=O)c(-c4ccc(Oc5ccccc5)cc4)nn32)CC1 CHEMBL3932338 IC50 1.2 nM
C=CC(=O)Nc1cccc(Nc2nc(Nc3ccc(CP(=O)(OCC)OCC)cc3)ncc2Cl)c1 CHEMBL3932000 IC50 1.23 nM
C=CC(=O)N1CC[C@H](Oc2nc(-c3n[nH]c(=O)[nH]3)cc3ccccc23)C1 CHEMBL5073622 pEC50 1.259 nM
Cn1cc(-c2cccc(N3CCc4c(sc5c4CC(C)(C)C5)C3=O)c2CO)cc(Nc2ccncn2)c1=O CHEMBL3670082 Ki(app) 1.28 nM
Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1 CHEMBL5416410 IC50 1.3 nM
CCN1CCN(C(C)(C)/C=C(\C#N)C(=O)N2CCC[C@H](n3nc(-c4ccc(Oc5ccccc5)cc4F)c4c(N)ncnc43)C2)CC1=O CHEMBL3918024 IC50 1.3 nM
CNC(C)(C)/C=C(\C#N)C(=O)N1CCC[C@@H]1Cn1nc(-c2ccc(Oc3cccc(F)c3F)cc2F)c2c(N)ncnc21 CHEMBL4114795 IC50 1.3 nM
CC(C)(C)/C=C(\C#N)C(=O)N1CCCC(n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1 CHEMBL4114765 IC50 1.3 nM
O=C1c2c(F)cc(C3CC3)cc2OCCN1c1cc(F)cc(-c2ccnc3[nH]c(CN4CCN(C5COC5)CC4)cc23)c1CO CHEMBL3941978 IC50 1.3 nM
O=C1c2c(F)cc(C3CC3)cc2OCCN1c1cc(F)cc(-c2ccnc3[nH]c(C4=CCN(C5COC5)CC4)cc23)c1CO CHEMBL3954122 IC50 1.3 nM
CC(O)C(=O)N1CC=C(c2cc3c(-c4cccc(N5CCOc6cc(C7CC7)cc(F)c6C5=O)c4CO)ccnc3[nH]2)CC1 CHEMBL3911350 IC50 1.3 nM
CCN1CCN(C(C)(C)/C=C(\C#N)C(=O)N2CCC[C@@H](n3nc(-c4ccc(Oc5ccccc5)cc4F)c4c(N)ncnc43)C2)CC1=O CHEMBL3702857 IC50 1.3 nM
CC(C)(/C=C(\C#N)C(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3F)c3c(N)ncnc32)C1)N1CCNC(=O)C1 CHEMBL3702858 IC50 1.3 nM
Cc1c(-c2c(Cl)cc(C(N)=O)c3[nH]c4cc(C(C)(C)O)ccc4c23)cccc1-n1c(=O)c2cccc(C)c2n(C)c1=O CHEMBL3903970 IC50 1.3 nM
Nc1ncnc2c1c(-c1ccc(C(=O)Nc3cc(C(F)(F)F)ccn3)cc1)nn2[C@H]1CCCc2nn(CCO)cc21 CHEMBL3943053 IC50 1.3 nM
C=CC(=O)Nc1ccccc1C1CCNc2c(C(N)=O)c(-c3ccc(OC4CCCC4)cc3)nn21 CHEMBL3904488 IC50 1.3 nM
C=CC(=O)N1CC([C@@H]2CCNc3c(C(N)=O)c(-c4ccc(Oc5ccccc5)cc4)nn32)C1 CHEMBL3937995 IC50 1.3 nM
C=CC(=O)Nc1ccccc1C1CCNc2c(C(N)=O)c(-c3ccc(OCc4ccccn4)c(Cl)c3)nn21 CHEMBL3959953 IC50 1.3 nM
Nc1nccn2c([C@H]3CC[C@@H]4COC(=O)N4C3)nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3F)c12 CHEMBL3899763 IC50 1.3 nM
C[C@@H]1OC(=N)N2C[C@H](c3nc(-c4ccc(C(=O)Nc5cc(C(F)(F)F)ccn5)cc4)c4c(N)nccn34)CC[C@@H]12 CHEMBL3968737 IC50 1.3 nM
CCOc1cc(C(=O)Nc2cc(C(F)(F)F)n(C)n2)c(F)cc1-c1nc([C@@H]2CC[C@H]3CCC(=O)N3C2)n2ccnc(N)c12 CHEMBL4106682 IC50 1.3 nM
COc1cc(C(=O)Nc2cc(C(F)(F)F)ccn2)ccc1-c1nc([C@@H]2CC[C@H]3CCC(=O)N3C2)n2c(F)cnc(N)c12 CHEMBL4115294 IC50 1.3 nM
Nc1ncc(F)n2c([C@@H]3CC[C@H]4CCC(=O)N4C3)nc(-c3ccc(C(=O)Nc4cc(C5CC5)ccn4)cc3F)c12 CHEMBL4114433 IC50 1.3 nM
C[C@]1(C(=O)O)CC[C@@H](c2nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3)c3c(N)nccn23)C1 CHEMBL4087578 IC50 1.3 nM
C[C@@H]1CN(c2ccc(Nc3cc(-c4ccnc(N5CCn6c(cc7c6CC(C)(C)C7)C5=O)c4CO)cn(C)c3=O)nc2)[C@@H](C)CN1C1COC1 CHEMBL4074792 Ki 1.3 nM
CC(C)(/C=C(\C#N)C(=O)N1CCC[C@H](n2nc(-c3ccc(Oc4ccccc4)cc3F)c3c(N)ncnc32)C1)N1CCN(C2COC2)CC1 CHEMBL3979355 IC50 1.3 nM
C=CC(=O)N[C@H]1CCN(c2ccc(C(N)=O)c(Nc3ccc(N4CCCCC4)cc3)n2)C1 CHEMBL4278321 IC50 1.3 nM
C=CC(=O)N(C)[C@H]1CCN(c2ccc(C(N)=O)c(Nc3ccc(CCN4CCCC4)cc3)n2)C1 CHEMBL4292583 IC50 1.3 nM
Cn1c2c(cc(Nc3ccc(C(=O)N4CCOCC4)cn3)c1=O)-c1cccc(-n3ncc4cc(C(C)(C)C)cc(F)c4c3=O)c1C[C@@H](O)C2 CHEMBL4466633 IC50 1.3 nM
CC(C)(/C=C(\C#N)C(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3F)c3c(N)ncnc32)C1)N1CCN(C2COC2)CC1 CHEMBL3702854 IC50 1.3 nM
Cc1cc(-c2ccnc3[nH]c(-c4cnn(C)c4)nc23)ccc1CNC(=O)c1ccc(C(C)(C)C)cc1 CHEMBL4849446 IC50 1.3 nM
CC(C)OC1CN(C(=O)NC2CCCc3cc(-c4ccnc(Nc5cnn(C)c5)n4)ccc32)C1 CHEMBL5090623 IC50 1.3 nM
C=CC(=O)N1CC=C(c2c[nH]c3ncnc(-c4ccc(CNC(=O)c5ccc(C(C)(C)C)cc5)c(F)c4)c23)CC1 CHEMBL5178389 IC50 1.3 nM
C=CC(=O)N1CCC(C2CCNc3c(C(N)=O)c(-c4cc(OC)c(C5CC5)c(OC)c4)nn32)CC1 CHEMBL5267491 IC50 1.3 nM
C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(NC(=O)c4ccccc4)c4c3OCO4)c3c(N)ncnc32)C1 CHEMBL5396054 IC50 1.3 nM
C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(NC(=O)c4ccc(Cl)cc4)c4c3OCO4)c3c(N)ncnc32)C1 CHEMBL5435684 IC50 1.3 nM
C=CC(=O)N[C@H]1CC[C@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)CC1 CHEMBL3912266 IC50 1.31 nM
C=CS(=O)(=O)N1CCC(Cn2cc(-c3ccc4c(c3)OCO4)c3c(N)ncnc32)CC1 CHEMBL4793094 IC50 1.32 nM
CN(C)C/C=C/C(=O)N1CCC[C@H]1Cn1nc(-c2ccc(Oc3ccccc3)cc2)c2c(N)ncnc21 CHEMBL3903249 IC50 1.33 nM
C=CC(=O)N1CC[C@]2(C1)C[C@H](n1c(NC(=O)c3ccc(C#N)cc3)nc3cc(CN[C@@H](C)C(C)(C)C)ccc31)C2 CHEMBL4210857 IC50 1.34 nM
C=CC(=O)N1CC=C(c2c[nH]c3ncnc(-c4ccc(CNC(=O)c5ccc(C(C)(C)C)cc5)c(C)c4)c23)CC1 CHEMBL5196670 IC50 1.34 nM
C=CC(=O)N(C)CCOc1cncnc1-c1ccc(CN2CCN(CC(C)(C)C)CC2=O)c(C)c1 CHEMBL5180944 IC50 1.35 nM
CN(C)C/C=C/C(=O)N[C@H]1CC[C@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)CC1 CHEMBL3893004 IC50 1.38 nM
CN(C)C/C=C/C(=O)NC1CCC(n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)CC1 CHEMBL3980550 IC50 1.38 nM
CN1CCCC1c1ccc(Nc2cc(-c3cc(F)cc(N4CCc5c(sc6c5CC(C)(C)C6)C4=O)c3CO)cn(C)c2=O)nc1 CHEMBL3670116 IC50 1.4 nM
CC(C)(/C=C(\C#N)C(=O)N1CCC[C@H](n2nc(-c3ccc(Oc4ccccc4)cc3F)c3c(N)ncnc32)C1)N1CCN(S(C)(=O)=O)CC1 CHEMBL3904226 IC50 1.4 nM
CN(C)C/C=C/C(=O)N[C@H]1CC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)CC1 CHEMBL3889694 IC50 1.4 nM
CNC(C)(C)/C=C(\C#N)C(=O)N1CCCC1Cn1nc(-c2ccc(Oc3ccccc3)cc2F)c2c(N)ncnc21 CHEMBL4114695 IC50 1.4 nM
CC(C)(O)CN1CC=C(c2cc3c(-c4cccc(N5CCOc6cc(C7CC7)cc(F)c6C5=O)c4CO)ccnc3[nH]2)CC1 CHEMBL3946460 IC50 1.4 nM
CC(C)(/C=C(\C#N)C(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3F)c3c(N)ncnc32)C1)N1CCN(S(C)(=O)=O)CC1 CHEMBL3702852 IC50 1.4 nM
C=CC(=O)N1CC(C2CCNc3c(C(N)=O)c(-c4ccc(Oc5ccc(Cl)cc5)cc4)nn32)C1 CHEMBL3953428 IC50 1.4 nM
CN(C)C/C=C/C(=O)N1CCC(C2CCNc3c(C(N)=O)c(-c4ccc(Oc5ccccc5)cc4)nn32)CC1 CHEMBL3969173 IC50 1.4 nM
Nc1nccn2c([C@@H]3CC[C@H]4CCC(=O)N4C3)nc(-c3ccc(C(=O)Nc4cc(C5CC5)ccn4)cc3OC3CC3)c12 CHEMBL4109428 IC50 1.4 nM
COc1cc(C(=O)Nc2ccc(C)cn2)ccc1-c1nc([C@@H]2CC[C@H]3CCC(=O)N3C2)n2c(Cl)cnc(N)c12 CHEMBL4115078 IC50 1.4 nM
Nc1nccn2c([C@@H]3CCC[C@H](c4noc(=O)[nH]4)C3)nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3)c12 CHEMBL4090257 IC50 1.4 nM
C=CC(=O)N1CCC[C@H]1COc1c(N)ncnc1-c1cc(F)cc(NC(=O)c2ccc(C3CC3)cc2F)c1C CHEMBL4537231 IC50 1.4 nM
C=CS(=O)(=O)NC1CCCN(c2ccc(C(N)=O)c3[nH]c(C)c(C)c23)C1 CHEMBL4638741 IC50 1.4 nM
C#CC(=O)N[C@@H]1CCCN(c2ccc(C(N)=O)c3[nH]c(C)c(C)c23)C1 CHEMBL4649352 IC50 1.4 nM
C=CC(=O)N1CC(O)(c2c[nH]c3ncnc(-c4cc(F)cc(NC(=O)c5ccc(C6CC6)cc5)c4C)c23)C1 CHEMBL4746262 IC50 1.4 nM
C=CC(=O)N1CC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)n[nH]c(=O)c32)C1 CHEMBL4761068 IC50 1.4 nM
C=CC(=O)N1CCC(CNc2ncnc3[nH]cc(C(=O)N4CC(Oc5ccc6ccccc6c5)C4)c23)CC1 CHEMBL5193597 IC50 1.4 nM
CC#CC(=O)N1CCC(c2c[nH]c3ncnc(-c4ccc(CNC(=O)c5ccc(C(C)(C)C)cc5)c(C)c4)c23)CC1 CHEMBL5179204 IC50 1.4 nM
CC#CC(=O)N1CC=C(c2c[nH]c3ncnc(-c4ccc(CNC(=O)Nc5ccccc5)c(F)c4)c23)CC1 CHEMBL5202754 IC50 1.4 nM
C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(NC(=O)c4ccccn4)c4c3OCO4)c3c(N)ncnc32)C1 CHEMBL5403374 IC50 1.4 nM
C=CC(=O)Nc1cccc(Nc2nc(Nc3ccc(OCCSC(=S)N(C)C)cc3)ncc2F)c1 CHEMBL4476232 IC50 1.44 nM
C=CC(=O)Nc1cccc(Nc2nc(Nc3ccc(N(C)C)nc3)ncc2[S+](C)[O-])c1 CHEMBL3786931 IC50 1.48 nM
C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(NC(=O)c4ccco4)c4c3OCO4)c3c(N)ncnc32)C1 CHEMBL5427871 IC50 1.48 nM
C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(NC(=O)C45CCC(CC4)C5)c4c3OCO4)c3c(N)ncnc32)C1 CHEMBL5426399 IC50 1.48 nM
CC(C)(/C=C(\C#N)C(=O)N1CCC[C@H](n2nc(-c3ccc(Oc4ccccc4)cc3F)c3c(N)ncnc32)C1)N1CC2(COC2)C1 CHEMBL3933784 IC50 1.5 nM
CN(C)C(C)(C)/C=C(\C#N)C(=O)N1CCC[C@H]1Cn1nc(-c2ccc(Oc3cccc(F)c3F)cc2F)c2c(N)ncnc21 CHEMBL3894014 IC50 1.5 nM
CN1CCN(Cc2ccc(-c3cc4c(-c5cccc(N6CCOc7cc(C8CC8)cc(F)c7C6=O)c5CO)ccnc4[nH]3)nc2)CC1=O CHEMBL3919488 IC50 1.5 nM
CCN1CC(N2CC=C(c3cc4c(-c5cccc(N6CCOc7cc(C8CC8)cc(F)c7C6=O)c5CO)ccnc4[nH]3)CC2)C1 CHEMBL3979659 IC50 1.5 nM
CC(C)(/C=C(\C#N)C(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3F)c3c(N)ncnc32)C1)N1CC2(COC2)C1 CHEMBL3702845 IC50 1.5 nM
C=CC(=O)Nc1ccccc1C1CCNc2c(C(N)=O)c(-c3ccc(OCc4ccccc4)cc3)nn21 CHEMBL3912412 IC50 1.5 nM
Nc1nccn2c([C@@H]3CC[C@H]4CCC(=O)N4C3)nc(-c3ccc(C(=O)Nc4cc(C(F)F)ccn4)c(F)c3)c12 CHEMBL4114570 IC50 1.5 nM
COC(C)c1ccnc(NC(=O)c2ccc(-c3nc([C@@H]4CC[C@H]5CCC(=O)N5C4)n4ccnc(N)c34)cc2)c1 CHEMBL4110507 IC50 1.5 nM
Nc1ncc(F)n2c([C@@H]3CC[C@H]4CCC(=O)N4C3)nc(-c3ccc(C(=O)Nc4cc(C5CC5)ccn4)cc3)c12 CHEMBL4113785 IC50 1.5 nM
COc1cc(C(=O)Nc2cc(C(F)(F)F)n(C)n2)ccc1-c1nc([C@@H]2CC[C@H]3CCC(=O)N3C2)n2c(Cl)cnc(N)c12 CHEMBL4111479 IC50 1.5 nM
Cc1cnc(NC(=O)c2ccc(-c3nc([C@@H]4CC[C@H]5CCC(=O)N5C4)n4c(Cl)cnc(N)c34)c(Cl)c2)s1 CHEMBL4115467 IC50 1.5 nM
C=CC(=O)N[C@H]1CCN(c2ccc(C(N)=O)c(Nc3ccc(C(=O)N4CCOCC4)cc3)n2)C1 CHEMBL4245727 IC50 1.5 nM
C=CC(=O)Nc1cccc(Nc2nc(Nc3ccc(B(O)O)cc3)ncc2C(F)(F)F)c1 CHEMBL4640647 IC50 1.5 nM
CC#CC(=O)Nc1cc2c(Oc3ccc(C(=O)Nc4ccccn4)cc3)ccnc2cc1OC CHEMBL4743222 IC50 1.5 nM
COc1cc2nccc(Oc3ccc(C(=O)Nc4ccccn4)cc3)c2cc1NC(=O)C#CCCN1CCOCC1 CHEMBL4755977 IC50 1.5 nM
Cn1cc(-c2nc3c(-c4ccc(CNC(=O)c5ccc(C(C)(C)C)cn5)c(F)c4)ccnc3[nH]2)cn1 CHEMBL4865481 IC50 1.5 nM
C#CC(=O)N1CCC(c2cnn3c(C(N)=O)c(-c4ccc(Oc5ccccc5F)cc4)[nH]c23)CC1 CHEMBL4869409 IC50 1.5 nM
C=CC(=O)N1CCC(C2CCNc3c(C(N)=O)c(-c4cc(OC)c(CC)c(OC)c4)nn32)CC1 CHEMBL5269683 IC50 1.5 nM
C=CC(=O)N1CCC(C2CCNc3c(C(N)=O)c(-c4cc(OC)c(C5CCCC5)c(OC)c4)nn32)CC1 CHEMBL5272694 IC50 1.5 nM
C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(NC(=O)c4ccc(OC)cc4)c4c3OCO4)c3c(N)ncnc32)C1 CHEMBL5413492 IC50 1.5 nM
Cc1ccc(O)cc1Nc1nc2ccc(N(C)C(=O)/C=C/CN(C)C)cc2n2cncc12 CHEMBL1916888 IC50 1.55 nM
CC#CC(=O)N[C@H]1CC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)CC1 CHEMBL3921655 IC50 1.57 nM
C=CC(=O)N(C)CCn1nc(-c2ccc(Oc3ccccc3)cc2)c2c(N)ncnc21 CHEMBL3921017 IC50 1.58 nM
C=CC(=O)N1CC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1 CHEMBL3647966 IC50 1.6 nM
C=CC(=O)N1CCC(n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1 CHEMBL3669312 IC50 1.6 nM
C=CC(=O)N1CC2(CC(n3nc(-c4ccc(Oc5ccccc5)cn4)c4c(N)ncnc43)C2)C1 CHEMBL3647524 IC50 1.6 nM
[C-]#[N+]/C(=C\C(C)(C)N)C(=O)N1CCC[C@@H]1Cn1nc(-c2ccc(Oc3cccc(F)c3)cc2F)c2c(N)ncnc21 CHEMBL4114718 IC50 1.6 nM
O=C1c2c(F)cc(C3CC3)cc2OCCN1c1cccc(-c2ccnc3[nH]c(-c4ccc(CN5CCN(CC(F)(F)F)CC5)cn4)cc23)c1CO CHEMBL3950703 IC50 1.6 nM
CN1CC(N2CC=C(c3cc4c(-c5cccc(N6CCOc7cc(C8CC8)cc(F)c7C6=O)c5CO)ccnc4[nH]3)CC2)C1 CHEMBL3936413 IC50 1.6 nM
C=CC(=O)Nc1ccccc1C1CCNc2c(C(N)=O)c(-c3ccc(C)cc3)nn21 CHEMBL3965262 IC50 1.6 nM
COc1cc(-c2nn3c(c2C(N)=O)NCCC3c2ccccc2NC(=O)/C=C/CN(C)C)ccc1C CHEMBL3940696 IC50 1.6 nM
CN1CC(=O)N2C[C@@H](c3nc(-c4ccc(C(=O)Nc5cc(C(F)(F)F)ccn5)cc4)c4c(N)nccn34)CC[C@@H]2C1 CHEMBL3905726 IC50 1.6 nM
COc1ccnc(NC(=O)c2ccc(-c3nc([C@@H]4CC[C@H]5CCC(=O)N5C4)n4c(Cl)cnc(N)c34)c(OC)c2)c1 CHEMBL4106703 IC50 1.6 nM
CC(C)(C#N)c1cc(F)c2c(c1)CCN(c1cccc(-c3nc(N)nc(Nc4ccc(N5CCOCC5)cc4)n3)c1CO)C2=O CHEMBL4205586 IC50 1.6 nM
C=CC(=O)N[C@H]1CCN(c2nc(Nc3ccc(N4C[C@@H](C)O[C@@H](C)C4)cc3)c(C(N)=O)cc2F)C1 CHEMBL4285813 IC50 1.6 nM
N#CN1CCC[C@@H](n2nc(-c3ccc(Oc4ccc(Cl)cn4)cc3)c(C(N)=O)c2N)C1 CHEMBL4469663 IC50 1.6 nM
C=CC(=O)N1CC[C@H](Nc2ccc(C(N)=O)c3[nH]c(C)c(C)c23)C1 CHEMBL4640555 IC50 1.6 nM
C=CC(=O)N[C@H]1CC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)n[nH]c(=O)c32)CC1 CHEMBL4746704 IC50 1.6 nM
C=CC(=O)N1CCC(CNc2ncnc3[nH]cc(C(=O)N4CC(Oc5cccc(C(F)(F)F)c5)C4)c23)CC1 CHEMBL5205889 IC50 1.6 nM
C=CC(=O)N(C)CCOc1cncnc1-c1ccc(CN2CCN(CC3CCC3)CC2=O)c(C)c1 CHEMBL5204339 IC50 1.6 nM
C=CC(=O)N1CCC(c2ccc(C(N)=O)c(-c3ccc(Oc4ccccc4)cc3)n2)CC1 CHEMBL4650321 IC50 1.6 nM
N#C/C(=C\C1CC1)C(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4cccc(F)c4)cc3)c3c(N)ncnc32)C1 CHEMBL4114702 IC50 1.7 nM
N#C/C(=C\C1CC1)C(=O)N1CCCC(n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1 CHEMBL3972359 IC50 1.7 nM
O=C1c2c(F)cc(C3CC3)cc2OCCN1c1cccc(-c2ccnc3[nH]c(-c4cnn(C5CCN(C6COC6)CC5)c4)cc23)c1CO CHEMBL3959033 IC50 1.7 nM
CC1CN(Cc2ccc(-c3cc4c(-c5cccc(N6CCOc7cc(C8CC8)cc(F)c7C6=O)c5CO)ccnc4[nH]3)nc2)CC(C)N1C CHEMBL3955997 IC50 1.7 nM
O=C(N1CC=C(c2cc3c(-c4cccc(N5CCOc6cc(C7CC7)cc(F)c6C5=O)c4CO)ccnc3[nH]2)CC1)N1CCOCC1 CHEMBL3921953 IC50 1.7 nM
C=C(C#N)C(=O)NCCOc1cccc(Nc2cc(-c3ccnc(N4CCn5c(cc6c5CC(C)(C)C6)C4=O)c3CO)cn(C)c2=O)n1 CHEMBL3896744 Ki 1.7 nM
C=CC(=O)Nc1cccc([C@@H]2CCNc3c(C(N)=O)c(-c4ccc(Oc5ccccc5)cc4)nn32)c1 CHEMBL3964332 IC50 1.7 nM
C=CC(=O)Nc1ccccc1C1CCNc2c(C(N)=O)c(-c3ccc(Oc4ccc(F)cc4)cc3)nn21 CHEMBL3906926 IC50 1.7 nM
C=CC(=O)N1CC(C2CCNc3c(C(N)=O)c(-c4ccc(Oc5ccc(Cl)c(Cl)c5)cc4)nn32)C1 CHEMBL3984082 IC50 1.7 nM
Nc1nccn2c([C@@H]3CC[C@H]4CCCC(=O)N4C3)nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3F)c12 CHEMBL4111979 IC50 1.7 nM
COc1cc(C(=O)Nc2ncc(C)s2)ccc1-c1nc([C@@H]2CC[C@H]3CCC(=O)N3C2)n2c(Cl)cnc(N)c12 CHEMBL4110442 IC50 1.7 nM
Cn1cc(Nc2nc(N)cc(-c3cccc(-n4ccc5cc(C6CC6)cc(F)c5c4=O)c3CO)n2)cc1C#N CHEMBL4216909 IC50 1.7 nM
C=CC(=O)Nc1cccc(Oc2nc(Nc3ccc4c(c3)COB4O)ncc2OC)c1 CHEMBL4649397 IC50 1.7 nM
Cc1c(-c2ccc(C(N)=O)c3[nH]c4cc(C(C)(C)O)ccc4c23)cccc1-n1c(=O)cc2ccccn2c1=O CHEMBL4741884 IC50 1.7 nM
Cc1cc(-c2ccnc(Nc3conc3C)n2)ccc1CNC(=O)c1cnc(C(C)(C)C)s1 CHEMBL4797536 IC50 1.7 nM
C=CC(=O)N1CCC(C2CCNc3c(C(N)=O)c(-c4ccc(Oc5ccccc5)c(O)c4)nn32)CC1 CHEMBL5274187 IC50 1.7 nM
C=CC(=O)N1CCC(C2CCNc3c(C(N)=O)c(-c4cc(OC)c(C)c(OC)c4)nn32)CC1 CHEMBL5266481 IC50 1.7 nM
C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(NC(=O)c4cccs4)c4c3OCO4)c3c(N)ncnc32)C1 CHEMBL5396925 IC50 1.7 nM
C=CC(=O)N1CCC[C@@H](Cn2cc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1 CHEMBL4790832 IC50 1.71 nM
CN1CCC[C@@H]1c1ccc(Nc2cc(-c3cc(F)cc(N4CCn5c(cc6c5CC(C)(C)C6)C4=O)c3CO)cn(C)c2=O)nc1 CHEMBL3670119 IC50 1.74 nM
C=CC(=O)N(C)CCOc1cccc(Nc2cc(-c3ccnc(N4CCn5c(cc6c5CC(C)(C)C6)C4=O)c3CO)cn(C)c2=O)n1 CHEMBL3904869 Ki 1.75 nM
CN(C)C/C=C/C(=O)N1CC2(CC(n3nc(-c4ccc(Oc5ccccc5)cc4)c4c(N)ncnc43)C2)C1 CHEMBL3647515 IC50 1.8 nM
N#C/C(=C\C1CC1)C(=O)N1CCC[C@@H]1Cn1nc(-c2ccc(Oc3ccccc3)cc2)c2c(N)ncnc21 CHEMBL4114764 IC50 1.8 nM
N#C/C(=C\C1CC1)C(=O)N1CCC[C@H]1Cn1nc(-c2ccc(Oc3cccc(F)c3F)cc2F)c2c(N)ncnc21 CHEMBL3975610 IC50 1.8 nM
Nc1nccn2c([C@H]3CC[C@@H]4COCCN4C3)nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3)c12 CHEMBL3906813 IC50 1.8 nM
Cn1nc(NC(=O)c2cc(OC3CC3)c(-c3nc([C@@H]4CC[C@H]5CCC(=O)N5C4)n4c(Cl)cnc(N)c34)cc2F)cc1C(F)(F)F CHEMBL4107623 IC50 1.8 nM
COc1cc(C(=O)Nc2cc(C(F)(F)F)ccn2)c(Cl)cc1-c1nc([C@@H]2CC[C@H]3CCC(=O)N3C2)n2c(Cl)cnc(N)c12 CHEMBL4113370 IC50 1.8 nM
Cn1cc(-c2ccnc(N3CCn4c(cc5c4CCCC5)C3=O)c2CO)cc(Nc2ccc(N3CCN(C4COC4)CC3)cn2)c1=O CHEMBL4085477 Ki 1.8 nM
CC1C=C(c2ccnc(N3CCn4c(cc5c4CC(C)(C)C5)C3=O)c2CO)C=C(Nc2ccc(N3CCN(C4COC4)CC3)cc2)C1=O CHEMBL4086408 Ki 1.8 nM
Cn1cc(-c2ccnc(N3CCn4c(cc5c4CC(C)(C)C5)C3=O)c2CO)cc(Nc2cccc(N3CCN(C4COC4)CC3)n2)c1=O CHEMBL4082268 Ki 1.8 nM
CC(=O)N1CCN(c2ccc(Nc3cc(-c4ccnc(N5CCn6c(cc7c6CC(C)(C)C7)C5=O)c4CO)cn(C)c3=O)nc2)CC1 CHEMBL4060356 Ki 1.8 nM
C=CC(=O)N1CC[C@]2(C1)C[C@H](n1c(NC(=O)c3cncs3)nc3cc(CN[C@@H](C)C(C)(C)C)ccc31)C2 CHEMBL4202618 IC50 1.8 nM
C=CC(=O)N(C)CC/C=C/c1c(N)ncnc1-c1cc(F)cc(NC(=O)c2ccc(C3CC3)cc2)c1C CHEMBL4450082 IC50 1.8 nM
C#CC(=O)N(C)CCOc1c(N)ncnc1-c1cc(F)cc(NC(=O)c2ccc(C3CC3)cc2F)c1C CHEMBL4471613 IC50 1.8 nM
Cc1cc(-c2ccnc(Nc3ccccc3)n2)ccc1CNC(=O)c1cnc(C(C)(C)C)s1 CHEMBL4788285 IC50 1.8 nM
C=CC(=O)Nc1cccc(-n2c(=O)cnc3cnc(Nc4ccc(OC)cc4)nc32)c1 CHEMBL2437479 IC50 1.8 nM
CC(C)(C)/C=C(\C#N)C(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3F)c3c(N)ncnc32)C1 CHEMBL4114766 IC50 1.8 nM
C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(NC(=O)c4cccc(Cl)c4)c4c3OCO4)c3c(N)ncnc32)C1 CHEMBL5402002 IC50 1.8 nM
C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(NC(=O)c4ccc(C(F)(F)F)cc4)c4c3OCO4)c3c(N)ncnc32)C1 CHEMBL5440136 IC50 1.8 nM
CN(C)C/C=C/C(=O)N(C)c1cc2c(cc1F)nc(Nc1ccccc1Cl)c1cncn12 CHEMBL1916892 IC50 1.82 nM
C=CC(=O)N1CCC(CNc2ncnc(N)c2-c2ccc(Oc3ccccc3)cc2)CC1 CHEMBL4072833 IC50 1.83 nM
Cc1c(F)cccc1Nc1nc2ccc(N(C)C(=O)/C=C/CN(C)C)cc2n2cncc12 CHEMBL1916882 IC50 1.89 nM
C=CC(=O)N1CC[C@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1 CHEMBL3647965 IC50 1.9 nM
CC(C)(/C=C(\C#N)C(=O)N1CCC[C@H]1Cn1nc(-c2ccc(Oc3ccccc3)cc2F)c2c(N)ncnc21)N1CCCC1 CHEMBL3702831 IC50 1.9 nM
CC(=O)N1CCN(C(C)(C)/C=C(\C#N)C(=O)N2CCC[C@H](n3nc(-c4ccc(Oc5ccccc5)cc4F)c4c(N)ncnc43)C2)CC1 CHEMBL3912580 IC50 1.9 nM
O=C1c2c(F)cc(C3CC3)cc2OCCN1c1cc(F)cc(-c2ccnc3[nH]c(-c4ccc(CN5CCN(CC(F)(F)F)CC5)cn4)cc23)c1CO CHEMBL3904999 IC50 1.9 nM
CC(=O)N1CCN(C(C)(C)/C=C(\C#N)C(=O)N2CCC[C@@H](n3nc(-c4ccc(Oc5ccccc5)cc4F)c4c(N)ncnc43)C2)CC1 CHEMBL3702855 IC50 1.9 nM
C=CC(=O)Nc1ccccc1C1CCNc2c(C(N)=O)c(-c3ccc(F)cc3)nn21 CHEMBL3908905 IC50 1.9 nM
Nc1nccn2c([C@@H]3CC[C@H]4CCC(=O)N4C3)nc(-c3ccc(C(=O)Nc4cc(C5(F)COC5)ccn4)cc3)c12 CHEMBL4112747 IC50 1.9 nM
COc1cc(C(=O)Nc2cc(C3CC3)ccn2)ccc1-c1nc([C@@H]2CC[C@H]3CCC(=O)N3C2)n2ccnc(N)c12 CHEMBL4109186 IC50 1.9 nM
CCOc1cc(C(=O)Nc2ncc(C)s2)ccc1-c1nc([C@@H]2CC[C@H]3CCC(=O)N3C2)n2c(F)cnc(N)c12 CHEMBL4114840 IC50 1.9 nM
Cn1nc(NC(=O)c2ccc(-c3nc([C@@H]4CC[C@H]5CCC(=O)N5C4)n4c(Cl)cnc(N)c34)c(Cl)c2)cc1C(F)(F)F CHEMBL4109244 IC50 1.9 nM
COCCOc1cc(C(=O)Nc2cccc(C(F)(F)F)c2)ccc1-c1nc([C@@H]2CC[C@H]3CCC(=O)N3C2)n2ccnc(N)c12 CHEMBL4114242 IC50 1.9 nM
CC(C)(/C=C(\C#N)C(=O)N1CCC[C@@H]1Cn1nc(-c2ccc(Oc3ccccc3)cc2F)c2c(N)ncnc21)NC1COC1 CHEMBL4093436 IC50 1.9 nM
CN(C1COC1)C(C)(C)/C=C(\C#N)C(=O)N1CCC[C@H]1Cn1nc(-c2ccc(Oc3ccccc3)cc2F)c2c(N)ncnc21 CHEMBL3702836 IC50 1.9 nM
C=CC(=O)Nc1cccc(-n2c(=O)c(=O)n(C(C)C)c3cnc(Nc4ccc(N5CCN(C)CC5)c(C)c4)nc32)c1 CHEMBL4288562 IC50 1.9 nM
C=CC(=O)N[C@H]1CCN(c2ccc(C(N)=O)c(Nc3ccc(N4C[C@@H](C)O[C@@H](C)C4)nc3)n2)C1 CHEMBL4282893 IC50 1.9 nM
C=CC(=O)N[C@H]1CCN(c2ccc(C(N)=O)c(Nc3ccc(CCN4CCCC4)cc3)n2)C1 CHEMBL4277875 IC50 1.9 nM
C=CC(=O)N(C)C/C=C/c1c(N)ncnc1-c1cc(F)cc(NC(=O)c2ccc(C3CC3)cc2F)c1C CHEMBL4546324 IC50 1.9 nM
C=CC(=O)Nc1cccc(Nc2nc(Nc3ccc4c(c3)B(O)OCC4)ncc2C(F)(F)F)c1 CHEMBL4648104 IC50 1.9 nM
Cn1cc(-c2cc(F)cc(-n3ncc4cc(C(C)(C)C)cc(F)c4c3=O)c2CO)cc(NC(=O)[C@H]2C[C@H]2F)c1=O CHEMBL4638277 IC50 1.9 nM
Cn1cc(-c2nc3c(-c4ccc(CN5CCc6cc(C(C)(C)C)ccc6C5=O)c(F)c4)ccnc3[nH]2)cn1 CHEMBL4855455 IC50 1.9 nM
Cn1cc(-c2nc3c(-c4ccc5c(c4)CCC[C@@H]5NC(=O)c4nc(C(C)(C)C)no4)ccnc3[nH]2)cn1 CHEMBL4869875 IC50 1.9 nM
C=CC(=O)N1CCCC[C@H]1c1nc(-c2ccc(C(=O)Nc3cc(-c4ccc(Cl)cc4)ccn3)cc2)c(C(N)=O)n1N CHEMBL4878626 IC50 1.9 nM
C#CC(=O)N1CCC(c2cnn3c(C(N)=O)c(-c4ccc(Oc5ccccc5F)cc4)[nH]c23)C1 CHEMBL4849585 IC50 1.9 nM
CC(C)/C=C(\C#N)C(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3F)c3c(N)ncnc32)C1 CHEMBL5170583 IC50 1.9 nM
C=CC(=O)N1CCCC(Nc2ncnc3[nH]cc(C(=O)N4CC(Oc5ccccc5)C4)c23)C1 CHEMBL5206716 IC50 1.9 nM
C=CC(=O)N1CCC(c2c[nH]c3ncnc(-c4ccc(CNC(=O)c5ccc(C(C)(C)C)cc5)c(F)c4)c23)CC1 CHEMBL5193930 IC50 1.9 nM
CC#CC(=O)N1CC=C(c2c[nH]c3ncnc(-c4ccc(CNC(=O)c5ccc(C6CC6)cc5)c(F)c4)c23)CC1 CHEMBL5179080 IC50 1.9 nM
Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)nn2[C@@H]1CCCN(C(=O)/C=C/CCCCOCCOCCOCCOCCOc2cccc3c2C(=O)N(C2CCC(=O)NC2=O)C3=O)C1 CHEMBL5278232 DC50 1.9 nM
O=C(CNc1cccc(Cl)c1)NC1CCCN(c2ncnc3[nH]ccc23)C1 CHEMBL4303247 IC50 1.9 nM
C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(NC(=O)c4cccc5c4CCCC5)c4c3OCO4)c3c(N)ncnc32)C1 CHEMBL5411595 IC50 1.9 nM
C=CC(=O)Nc1cccc(-c2n[nH]c(NCc3c(F)cccc3Cl)n2)c1 CHEMBL4101977 IC50 1.91 nM
C=CC(=O)N1CCCC(c2c(Cl)c(-c3ccc(Oc4ccc(Cl)c(Cl)c4)c(OC)c3)c3c(N)ncnn23)C1 CHEMBL2057913 IC50 2.0 nM
C=CC(=O)N1CCC[C@@H](n2nc(-c3cccc(C(=O)Nc4ccc(C(C)C)c(C)c4)c3)c3c(N)ncnc32)C1 CHEMBL2179805 IC50 2.0 nM
C=CC(=O)N1CCCC(c2c(Cl)c(-c3ccc(Oc4cccc(Cl)c4)c(OC)c3)c3c(N)ncnn23)C1 CHEMBL2216828 IC50 2.0 nM
CCN1CCN(c2ccc(Nc3cc(-c4cccc(-n5ncc6cc(C(C)(C)C)cc(F)c6c5=O)c4CO)cn(C)c3=O)nc2)CC1 CHEMBL3358345 IC50 2.0 nM
Cc1cc2cn[nH]c2cc1-c1cccc2c(N)c(C(N)=O)nnc12 CHEMBL3586447 IC50 2.0 nM
Cc1c(-c2cc(Nc3cc4n(n3)CCN(C)C4)c(=O)[nH]n2)cccc1N1CCn2c(cc3c2CCCC3)C1=O CHEMBL3670078 IC50 2.0 nM
CCn1cc(Nc2nc(-c3cccc(N4CCc5c(sc6c5CC(C)(C)C6)C4=O)c3CO)cn(C)c2=O)cn1 CHEMBL3670092 IC50 2.0 nM
CN(C)CCOc1ccc(Nc2cc(-c3cc(F)cc(N4CCc5c(sc6c5CCCC6)C4=O)c3CO)cn(C)c2=O)nc1 CHEMBL3670098 IC50 2.0 nM
CNC(=O)c1ccc(-c2cc3[nH]nc(N)c3c(-c3ccc(Oc4ccccc4)cc3)n2)cc1 CHEMBL3657232 IC50 2.0 nM
Nc1n[nH]c2cc(-c3ccc(-c4nnn[nH]4)cc3)nc(-c3ccc(Oc4ccccc4)cc3)c12 CHEMBL3657234 IC50 2.0 nM
COC(=O)C(=O)N1CCCC(c2cc3[nH]nc(N)c3c(-c3ccc(Oc4ccccc4)cc3)n2)C1 CHEMBL3657238 IC50 2.0 nM
Nc1n[nH]c2cc(C3CCN(C(=O)Nc4ccccc4)CC3)nc(-c3ccc(Oc4ccccc4)cc3)c12 CHEMBL3657239 IC50 2.0 nM
Nc1n[nH]c2cc(-c3ccc(C(=O)O)cc3)nc(-c3ccc(Oc4cccc(F)c4)cc3)c12 CHEMBL3657244 IC50 2.0 nM
COC(=O)N1CCN(C(C)(C)/C=C(\C#N)C(=O)N2CCC[C@H](n3nc(-c4ccc(Oc5ccccc5)cc4F)c4c(N)ncnc43)C2)CC1 CHEMBL3890002 IC50 2.0 nM
CC#CC(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1 CHEMBL4106607 IC50 2.0 nM
N#C/C(=C\C1CC1)C(=O)N1CCC[C@@H]1Cn1nc(-c2ccc(Oc3cccc(F)c3F)cc2)c2c(N)ncnc21 CHEMBL4114753 IC50 2.0 nM
CC(C)C(=O)N1CCC[C@@H]1Cn1nc(-c2ccc(Oc3cccc(F)c3F)cc2F)c2c(N)ncnc21 CHEMBL4109651 IC50 2.0 nM
N#C/C(=C\C1CC1)C(=O)N1CCC[C@@H](n2cc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1 CHEMBL4114679 IC50 2.0 nM
CC(C)/C=C(\C#N)C(=O)N1CCCC(n2nc(-c3ccc(Oc4ccccc4)cc3F)c3c(N)ncnc32)C1 CHEMBL4114802 IC50 2.0 nM
C[C@H](Cn1nc(-c2ccc(Oc3ccccc3)cc2F)c2c(N)ncnc21)NC(=O)/C(C#N)=C/C(C)(C)C CHEMBL4114691 IC50 2.0 nM
Cc1c(NC(=O)c2ccc(N(C)C(C)C)cc2)cc(F)cc1-c1ncnc2[nH]c(C3=CCN(C(=O)N(C)C)CC3)cc12 CHEMBL3984000 IC50 2.0 nM
Cc1c(NC(=O)c2ccc(C(C)(C)CO)cc2)cc(F)cc1-c1ncnc2[nH]c(C3=CCN(C(=O)N(C)C)CC3)cc12 CHEMBL3902940 IC50 2.0 nM
CN(C)C(=O)N1CC=C(c2cc3c(-c4cccc(NC(=O)c5ccc(C(C)(C)O)cc5F)c4CO)ncnc3[nH]2)CC1 CHEMBL3968447 IC50 2.0 nM
Cc1c(NC(=O)c2ccc(C(C)(C)C)cc2)cc(F)cc1-c1ncnc2[nH]c(C3=CC[S+]([O-])CC3)cc12 CHEMBL3967153 IC50 2.0 nM
CN(C)C(=O)N1CC=C(c2cc3c(-c4cccc(N5CCc6cc(C(C)(C)O)ccc6C5=O)c4CO)ncnc3[nH]2)CC1 CHEMBL3984599 IC50 2.0 nM
CN(C)C1CC=C(c2cc3c(-c4cccc(NC(=O)c5ccc(C(C)(C)C)cc5)c4CO)ncnc3[nH]2)CC1 CHEMBL3940129 IC50 2.0 nM
CN(C)C(=O)N1CC=C(c2cc3c(-c4ccc(F)c(NC(=O)N5CC(OC(C)(C)C)C5)c4)ncnc3[nH]2)CC1 CHEMBL3929806 IC50 2.0 nM
Cc1c(-c2ncnc3[nH]c(C4=CCN(C(=O)N(C)C)CC4)cc23)ccc(F)c1NC(=O)N1CC(OC(C)(C)C)C1 CHEMBL3968367 IC50 2.0 nM
CN1CCN(Cc2ccc(-c3cc4c(-c5cccc(-n6ncc7cc(C8CC8)ccc7c6=O)c5CO)ncnc4[nH]3)cc2)CC1 CHEMBL3980912 IC50 2.0 nM
CN1CCC(n2cc(-c3cc4c(-c5cccc(-n6ncc7cc(C8CC8)ccc7c6=O)c5CO)ncnc4[nH]3)cn2)CC1 CHEMBL3952007 IC50 2.0 nM
CCN1CCN(Cc2ccc(-c3cc4c(-c5cccc(N6CCOc7cc(C8CC8)ccc7C6=O)c5CO)ccnc4[nH]3)nc2)CC1 CHEMBL3906723 IC50 2.0 nM
CC(C)N1CCN(Cc2ccc(-c3cc4c(-c5cccc(N6CCOc7cc(C8CC8)ccc7C6=O)c5CO)ccnc4[nH]3)nc2)CC1 CHEMBL3963720 IC50 2.0 nM
CCN1CCN(Cc2ccc(-c3cc4c(-c5cccc(N6CCOc7cc(C8CC8)cc(F)c7C6=O)c5CO)ccnc4[nH]3)nc2)CC1 CHEMBL3967108 IC50 2.0 nM
O=C1c2c(F)cc(C3CC3)cc2OCCN1c1cccc(-c2ccnc3[nH]c(-c4ccc(CN5CCN(C6COC6)CC5)cn4)cc23)c1CO CHEMBL3928390 IC50 2.0 nM
NC(=O)c1ccc(-c2cc3c(-c4cccc(N5CCOc6cc(C7CC7)ccc6C5=O)c4CO)ccnc3[nH]2)nc1 CHEMBL3949916 IC50 2.0 nM
CN(C)C(=O)N1CC=C(c2cc3c(-c4cccc(N5CCOc6cc(C7CC7)ccc6C5=O)c4CO)ccnc3[nH]2)CC1 CHEMBL3959052 IC50 2.0 nM
COC(=O)N1CCN(C(C)(C)/C=C(\C#N)C(=O)N2CCC[C@@H](n3nc(-c4ccc(Oc5ccccc5)cc4F)c4c(N)ncnc43)C2)CC1 CHEMBL3702856 IC50 2.0 nM
CC#CC(=O)N1CCC[C@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1 CHEMBL3929922 IC50 2.0 nM
Cn1ncc2c1CCC[C@]2(O)c1nc(-c2ccc(C(=O)Nc3cc(C(F)(F)F)ccn3)cc2)c2c(N)nccn12 CHEMBL4109483 IC50 2.0 nM
Nc1nccn2c([C@@H]3CC[C@H]4CCC(=O)N4C3)nc(-c3ccc(C(=O)Nc4ccccn4)cc3)c12 CHEMBL4112851 IC50 2.0 nM
CCOc1cc(C(=O)Nc2cc(C3CC3)ccn2)c(F)cc1-c1nc([C@@H]2CC[C@H]3CCC(=O)N3C2)n2ccnc(N)c12 CHEMBL4112206 IC50 2.0 nM
Cn1cc(-c2cccc(N3CCn4c(cc5c4CC(C)(C)C5)C3=O)c2CO)cc(Nc2ccncn2)c1=O CHEMBL4090189 IC50 2.0 nM
C=CC(=O)Nc1cc(-n2c(=O)ccc3cnc4ccc(-c5cn[nH]c5)cc4c32)ccc1C CHEMBL4075449 Ki 2.0 nM
Cc1cc2[nH]ncc2cc1-c1cccc2c(N)c(C(N)=O)nnc12 CHEMBL4172284 IC50 2.0 nM
C=CC(=O)Nc1cc(Nc2ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n2)c(OC)cc1N(C)CCN(C)C CHEMBL4473365 IC50 2.0 nM
C=CC(=O)Nc1cccc(C2CCNc3c(C(N)=O)c(-c4ccc(Oc5ccccc5)cc4)nn32)c1 CHEMBL3921167 IC50 2.0 nM
Cc1c(-c2ccc(C(N)=O)c3[nH]c4cc(C(C)(C)O)ccc4c23)cccc1N1Cc2ccc(F)cc2C1=O CHEMBL4543505 IC50 2.0 nM
Cc1c(-c2ccc(C(N)=O)c3[nH]c4cc(C(C)(C)O)ccc4c23)cccc1-n1cnc2cc(F)ccc2c1=O CHEMBL4467132 IC50 2.0 nM
Cc1c(-c2ccc(C(N)=O)c3[nH]c4cc(C(C)(C)O)ccc4c23)cccc1-n1cnc2c(F)cccc2c1=O CHEMBL4460221 IC50 2.0 nM
C=CC(=O)Nc1cccc(Nc2nc(Nc3ccc4c(c3)B(O)OC4(C)C)ncc2C(F)(F)F)c1 CHEMBL4645290 IC50 2.0 nM
Cn1cc(-c2cc(F)cc(-n3ncc4cc(C(C)(C)C)cc(F)c4c3=O)c2CO)cc(NC(=O)[C@@H]2C[C@@H]2F)c1=O CHEMBL4643319 IC50 2.0 nM
Cc1cc(-c2ccnc(Nc3cnn(C)c3)n2)ccc1CNC(=O)c1nnc(C(C)(C)C)s1 CHEMBL4749757 IC50 2.0 nM
Cc1cc(-c2ccnc(Nc3cnn(C)c3)n2)ccc1CNC(=O)C1CCC(C(C)(C)C)C1 CHEMBL4760128 IC50 2.0 nM
N#C/C(=C\C1CC1)C(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3F)c3c(N)ncnc32)C1 CHEMBL5204545 IC50 2.0 nM
C=CC(=O)N1CCC(CNc2ncnc3[nH]cc(C(=O)N4CC(OCc5ccccc5)C4)c23)CC1 CHEMBL5175574 IC50 2.0 nM
CN(c1ncnc2[nH]ccc12)C1COCCN(C(=O)CNc2cc(Cl)cc(Cl)c2)C1 CHEMBL5284310 IC50 2.0 nM
C[C@@H]1[C@H](Nc2ncnc3[nH]ccc23)CCCN1C(=O)CNc1cc(Cl)cc(Cl)c1 CHEMBL5274179 IC50 2.0 nM
CC1C(N(C)c2ncnc3[nH]ccc23)CCCN1C(=O)CNc1cc(Cl)cc(Cl)c1 CHEMBL5269111 IC50 2.0 nM
O=C(CNc1cc(Cl)cc(C(F)(F)F)c1)N1CC[C@H]2CCN(c3ncnc4[nH]ccc34)[C@H]2C1 CHEMBL5287698 IC50 2.0 nM
C=CC(=O)N1CCC(C2CCNc3c(C(N)=O)c(-c4cc(Cl)c(Cl)c(Cl)c4)nn32)CC1 CHEMBL5266477 IC50 2.0 nM
C=CC(=O)N1CCC(C2CCNc3c(C(N)=O)c(-c4cc(Cl)c(Br)c(Cl)c4)nn32)CC1 CHEMBL5283553 IC50 2.0 nM
C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(NC(=O)c4ccccc4Cl)c4c3OCO4)c3c(N)ncnc32)C1 CHEMBL5403745 IC50 2.0 nM
C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(NC(=O)c4ccc(N(C)C)cc4)c4c3OCO4)c3c(N)ncnc32)C1 CHEMBL5415543 IC50 2.0 nM
CN1CCCC1c1ccc(Nc2cc(-c3cc(F)cc(N4CCc5c(sc6c5CCCC6)C4=O)c3CO)cn(C)c2=O)nc1 CHEMBL3670117 IC50 2.1 nM
N#C/C(=C\C1CC1)C(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4cc(F)cc(F)c4)cc3)c3c(N)ncnc32)C1 CHEMBL4114740 IC50 2.1 nM
CN(C/C=C/C(=O)N1CCCC(n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1)CCO CHEMBL3931858 IC50 2.1 nM
Nc1ncnc2c1c(-c1ccc(C(=O)Nc3cc(C(F)(F)F)ccn3)cc1)nn2[C@H]1CCCc2c1cnn2CCO CHEMBL3913277 IC50 2.1 nM
C=CC(=O)Nc1ccccc1C1CCNc2c(C(N)=O)c(-c3ccc(C(F)(F)F)c(Cl)c3)nn21 CHEMBL3903690 IC50 2.1 nM
NC(=O)c1c(-c2ccc(Oc3ccccc3)cc2)nn2c1NCC[C@H]2C1CCN(C(=O)C#CCN2CCCC2)CC1 CHEMBL3891285 IC50 2.1 nM
N#Cc1cnc(NC(=O)c2ccc(-c3nc([C@@H]4CC[C@H]5CCC(=O)N5C4)n4ccnc(N)c34)cc2)cc1C(F)(F)F CHEMBL4114368 IC50 2.1 nM
C=C1c2c(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc3n2CC1NC(=O)C#CC CHEMBL4209773 IC50 2.1 nM
Nc1nc(Nc2ccc(N3CCOCC3)cc2)nc(-c2cccc(NC(=O)c3ccc(C4CC4)cc3)c2CO)n1 CHEMBL4204802 IC50 2.1 nM
C=CC(=O)N1CC2(CC(Nc3ncnc(N)c3-c3ccc(Oc4ccccc4)cc3)C2)C1 CHEMBL4515024 IC50 2.1 nM
Cc1cc(-c2ccnc(Nc3ccn(C)n3)n2)ccc1CNC(=O)c1cnc(C(C)(C)C)s1 CHEMBL4792826 IC50 2.1 nM
C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)n[nH]c(=O)c32)C1 CHEMBL4754834 IC50 2.1 nM
Nc1nc(-c2cccc(-n3ccc4cc(C5CC5)cc(F)c4c3=O)c2CO)c2cc(-c3cccnc3)[nH]c2n1 CHEMBL5091338 IC50 2.1 nM
C=CC(=O)N1CCC(c2c[nH]c3ncnc(-c4ccc(CNC(=O)c5ccc(C(C)(C)C)cc5)cc4)c23)CC1 CHEMBL5187153 IC50 2.1 nM
C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(NC(=O)c4ccc(-c5ccccc5)cc4)c4c3OCO4)c3c(N)ncnc32)C1 CHEMBL5439377 IC50 2.1 nM
C=CC(=O)N1CC[C@]2(C1)C[C@H](n1c(NC(=O)c3ccc(C(C)(F)F)s3)nc3ccccc31)C2 CHEMBL4204572 IC50 2.11 nM
C=CC(=O)N[C@H]1CCCN(c2cccc(Nc3cc(-c4cc(F)cc(-n5ncc6c7c(sc6c5=O)CCCC7)c4CO)cn(C)c3=O)n2)C1 CHEMBL3973265 Ki 2.16 nM
Cc1c(-c2c(F)cc(C(N)=O)c3[nH]c4c(c23)CC[C@@H](C(C)(C)O)C4)cccc1-n1c(=O)c2cccc(F)c2n(C)c1=O CHEMBL3952795 IC50 2.2 nM
Cc1cc(Nc2cc(-c3cc(F)cc(N4CCn5c(cc6c5CC(C)(C)C6)C4=O)c3CO)cn(C)c2=O)[nH]n1 CHEMBL3670105 IC50 2.2 nM
CN1CCC(c2ccc(Nc3cc(-c4cc(F)cc(N5CCc6c(sc7c6CC(C)(C)C7)C5=O)c4CO)cn(C)c3=O)nc2)CC1 CHEMBL3670123 IC50 2.2 nM
CC(C)(N)/C=C(\C#N)C(=O)N1CCC[C@@H]1Cn1nc(-c2ccc(Oc3ccccc3)cc2F)c2c(N)ncnc21 CHEMBL4114723 IC50 2.2 nM
CC(=O)N1CC(N2CC=C(c3cc4c(-c5cccc(N6CCOc7cc(C8CC8)cc(F)c7C6=O)c5CO)ccnc4[nH]3)CC2)C1 CHEMBL3909430 IC50 2.2 nM
C=CC(=O)NCC1CNc2c(C(N)=O)c(-c3ccc(Oc4ccccc4)cc3)nn2C1 CHEMBL3894155 IC50 2.2 nM
Cc1cnc(NC(=O)c2ccc(-c3nc([C@@H]4CC[C@H]5CCC(=O)N5C4)n4ccnc(N)c34)cc2)s1 CHEMBL4112500 IC50 2.2 nM
Nc1nccn2c([C@@H]3CC[C@H]4CCC(=O)N4C3)nc(-c3ccc(C(=O)Nc4nccc(C(F)(F)F)n4)cc3)c12 CHEMBL4109782 IC50 2.2 nM
Cn1nc(NC(=O)c2ccc(-c3nc([C@@H]4CC[C@H]5CCC(=O)N5C4)n4ccnc(N)c34)c(Cl)c2)cc1C(F)(F)F CHEMBL4112629 IC50 2.2 nM
Cc1cc(C(=O)Nc2cc(C(F)(F)F)ccn2)cc(F)c1-c1nc([C@@H]2CC[C@H]3CCC(=O)N3C2)n2ccnc(N)c12 CHEMBL4111005 IC50 2.2 nM
CC#CC(=O)N1CCC[C@@H](n2c(=O)n(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1 CHEMBL4175428 IC50 2.2 nM
C=CC(=O)N[C@@H]1Cn2c(c(-c3ccc(Oc4ccc(F)cc4)cc3)c3c(N)ncnc32)C1=C CHEMBL4217114 IC50 2.2 nM
Nc1nc(Nc2ccc(N3CCOCC3)cc2)nc(-c2cccc(N3CCc4cc(C5CC5)cc(F)c4C3=O)c2CO)n1 CHEMBL4217295 IC50 2.2 nM
C=CC(=O)N[C@H]1CCN(c2ccc(C(N)=O)c(Nc3ccc(N4CCOCC4)nc3)n2)C1 CHEMBL4286628 IC50 2.2 nM
C=CC(=O)Nc1cccc(-n2c(=O)c(C3CCCC3)nc3cnc(Nc4ccc(OCCOC)cc4)nc32)c1 CHEMBL5087793 IC50 2.2 nM
C=CC(=O)N1CCC(O)(CNc2ncnc3[nH]cc(C(=O)N4CC(Oc5ccccc5)C4)c23)CC1 CHEMBL5206093 IC50 2.2 nM
CC#CC(=O)N1CCC(c2c[nH]c3ncnc(-c4ccc(CNC(=O)c5ccc(C(C)(C)C)cc5)cc4)c23)CC1 CHEMBL5206497 IC50 2.2 nM
Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)nn2[C@@H]1CCCN(C(=O)CCCCCCOCCOCCOCCOCCOc2cccc3c2C(=O)N(C2CCC(=O)NC2=O)C3=O)C1 CHEMBL5270491 DC50 2.2 nM
CC#CC(=O)N1CC[C@H](n2c(=O)n(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1 CHEMBL3892767 IC50 2.2 nM
CC#CC(=O)N1CC[C@H](N2CN(c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1 CHEMBL5285357 IC50 2.2 nM
C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(NC(=O)c4ccc(N(CC)CC)cc4)c4c3OCO4)c3c(N)ncnc32)C1 CHEMBL5412767 IC50 2.2 nM
C[C@H]1CN(C(=O)CNc2cccc3c2C(=O)N(C2CCC(=O)NC2=O)C3=O)CCN1c1ccc(Nc2cc(-c3ccnc(N4CCn5c(cc6c5CC(C)(C)C6)C4=O)c3CO)cn(C)c2=O)nc1 CHEMBL5408743 Kd 2.28 nM
Cc1c(NC(=O)c2cc3c(s2)CCCC3)cccc1-c1cn(C)c(=O)c(Nc2ccc([C@@H]3C(=O)N(C)CCN3C)cc2)n1 CHEMBL2057915 IC50 2.3 nM
Cc1c(-c2ccc(C(N)=O)c3[nH]c4cc(C(C)(C)O)ccc4c23)cccc1-n1c(=O)c2cccc(F)c2n(C)c1=O CHEMBL3908310 IC50 2.3 nM
N#C/C(=C\C1CC1)C(=O)N1CCC[C@H](n2nc(-c3ccc(Oc4cc(F)cc(F)c4)cc3)c3c(N)ncnc32)C1 CHEMBL4114800 IC50 2.3 nM
Nc1ncc(F)n2c([C@@H]3CC[C@H]4CCC(=O)N4C3)nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3O)c12 CHEMBL4108849 IC50 2.3 nM
Cc1c(NC(=O)c2ccc(C(C)(C)C)cc2)cccc1-c1ccnc(Nc2ccc(C(=O)N3CCOCC3)cc2)n1 CHEMBL4203409 IC50 2.3 nM
C=CC(=O)N[C@H]1CCN(c2ccc(C(N)=O)c(Nc3ccc(N4CCCCC4)nc3)n2)C1 CHEMBL4278717 IC50 2.3 nM
C=CC(=O)N1CC(Oc2c(N)ncnc2-c2cc(F)cc(NC(=O)c3ccc(C(C)(C)O)c(F)c3F)c2C)C1 CHEMBL4463185 IC50 2.3 nM
NC(=O)c1c(-c2ccc(Oc3ccc(F)cc3F)cc2)nn([C@@H]2CCCN(C(=O)/C=C/CO)C2)c1N CHEMBL4440096 IC50 2.3 nM
Cn1cc(-c2ccnc(N3CCn4c(cc5c4CC(C)(C)C5)C3=O)c2CO)cc(NC(=O)[C@@H]2C[C@@H]2F)c1=O CHEMBL4644207 IC50 2.3 nM
C=CC(=O)Nc1cccc(-n2c(=O)c(-c3ccccc3Cl)nc3cnc(Nc4ccc(OCCOC)cc4)nc32)c1 CHEMBL5075594 IC50 2.3 nM
C=CC(=O)N1CCC(C2CCNc3c(C(N)=O)c(-c4cc(OC)c(Cl)c(OC)c4)nn32)CC1 CHEMBL5289250 IC50 2.3 nM
Cn1cc(-c2cc(F)cc(N3CCn4c(cc5c4CC(C)(C)C5)C3=O)c2CO)cc(Nc2ccc(CN3CCOCC3)cn2)c1=O CHEMBL3670103 IC50 2.34 nM
CC#CC(=O)NCCOc1cccc(Nc2cc(-c3ccnc(N4CCn5c(cc6c5CC(C)(C)C6)C4=O)c3CO)cn(C)c2=O)n1 CHEMBL3905684 Ki 2.37 nM
C=CC(=O)Nc1cccc(Nc2nc(Nc3ccc(OCCCSC(=S)NCc4cccnc4)cc3)ncc2F)c1 CHEMBL4437107 IC50 2.39 nM
C=CC(=O)N1CC2(CC(n3nc(-c4ccc(Oc5ccccc5)nc4)c4c(N)ncnc43)C2)C1 CHEMBL3647521 IC50 2.4 nM
C=CC(=O)Nc1ccccc1C1CCNc2c(C(N)=O)c(-c3cc(OC)c(OC)c(OC)c3)nn21 CHEMBL3946044 IC50 2.4 nM
CC(C)=CC(=O)Nc1cccc(-c2ccc(C(N)=O)c3[nH]c4cc(C(C)(C)O)ccc4c23)c1C CHEMBL4251151 IC50 2.4 nM
C=CC(=O)Nc1cccc(-n2c(=O)c(=O)n(C(C)C)c3cnc(Nc4ccc(N5CCN(C)CC5)c(OC)c4)nc32)c1 CHEMBL4277912 IC50 2.4 nM
C#CC(=O)N1CC[C@H](Nc2ccc(C(N)=O)c3[nH]c(C)c(C)c23)C1 CHEMBL4649284 IC50 2.4 nM
Cn1cc(-c2ccnc(-n3ncc4cc(C(C)(C)C)cc(F)c4c3=O)c2CO)cc(NC(=O)[C@@H]2C[C@@H]2F)c1=O CHEMBL4634904 IC50 2.4 nM
C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(NC(=O)c4ccc[nH]4)c4c3OCO4)c3c(N)ncnc32)C1 CHEMBL5428711 IC50 2.4 nM
C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(NC(=O)c4sc5ccccc5c4Cl)c4c3OCO4)c3c(N)ncnc32)C1 CHEMBL5404479 IC50 2.4 nM
COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl CHEMBL288441 IC50 2.5 nM
O=C1c2ccc(C3CC3)cc2OCCN1c1cc(F)cc(-c2ccnc3[nH]c(C4=CCN(C5COC5)CC4)cc23)c1CO CHEMBL3962739 IC50 2.5 nM
C=CC(=O)Nc1cccc([C@H]2CCNc3c(C(N)=O)c(-c4ccc(Oc5ccccc5)cc4)nn32)c1 CHEMBL4108484 IC50 2.5 nM
N#Cc1ccnc(NC(=O)c2ccc(-c3nc([C@@H]4CC[C@H]5CCC(=O)N5C4)n4ccnc(N)c34)cc2F)c1 CHEMBL4111685 IC50 2.5 nM
COc1cc(C(=O)Nc2cc(C(F)(F)F)ccn2)c(F)cc1-c1nc([C@@H]2CC[C@H]3CCC(=O)N3C2)n2ccnc(N)c12 CHEMBL4111374 IC50 2.5 nM
CC1C=C(c2ccnc(N3CCn4c5c(c(F)c4C3=O)CCCC5)c2CO)C=C(Nc2ccc(N3CCN(C4COC4)CC3)cc2)C1=O CHEMBL4090946 Ki 2.5 nM
COc1ccc(Nc2nc(N)cc(-c3cccc(-n4ccc5cc(C6CC6)cc(F)c5c4=O)c3CO)n2)cc1 CHEMBL4214229 IC50 2.5 nM
CC(C)c1ccc(C(=O)Nc2cccc(-c3nc(N)nc(Nc4ccc(N5CCOCC5)cc4)n3)c2CO)cc1 CHEMBL4205287 IC50 2.5 nM
C=CC(=O)Nc1cccc(Nc2nc(Nc3ccc(OCCSC(=S)NC4CC4)cc3)ncc2F)c1 CHEMBL4470534 IC50 2.5 nM
CC1(C(=O)N2CCC[C@@H](c3nc(-c4ccc(C(=O)Nc5cc(C(F)(F)F)ccn5)c(F)c4)c4c(N)nccn34)C2)COC1 CHEMBL4779908 IC50 2.5 nM
CCN1CCN(CC#CC(=O)Nc2ccc3nccc(Oc4ccc(C(=O)Nc5ccccn5)cc4)c3c2)CC1 CHEMBL4796130 IC50 2.5 nM
C=CC(=O)N1CC=C(c2c[nH]c3ncnc(-c4ccc(CNC(=O)c5ccc(C(C)(C)C)cc5)cc4)c23)CC1 CHEMBL5188524 IC50 2.5 nM
CN1CCn2nc(Nc3cc(-c4ccnc(N5CCn6c(cc7c6CCCC7)C5=O)c4CO)nn4ccnc34)cc2C1 CHEMBL5169992 IC50 2.5 nM
C=C(Cl)C(=O)N1CCC[C@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1 CHEMBL5178356 IC50 2.5 nM
C=C(Cl)C(=O)N1CCC(n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)CC1 CHEMBL5271514 IC50 2.5 nM
Cn1cc(-c2cccc(-n3ncc4cc(C(C)(C)C)cc(F)c4c3=O)c2CO)cc1C(N)=O CHEMBL3649455 IC50 2.51 nM
C=C(CN1CCOCC1)C(=O)Nc1cc2c(cc1OC)nc(Nc1ccccc1C)c1cncn12 CHEMBL1916714 IC50 2.52 nM
C=CC(=O)N[C@@H](C)COc1cccc(Nc2cc(-c3cc(F)cc(-n4ncc5c6c(sc5c4=O)CCCC6)c3CO)cn(C)c2=O)n1 CHEMBL3959446 Ki 2.57 nM
C=CC(=O)N1CC[C@]2(C1)C[C@H](n1c(NC(=O)c3ccc(C(F)F)s3)nc3cc(CN4CCOCC4)ccc31)C2 CHEMBL4218914 IC50 2.59 nM
Cc1ccc(F)cc1Nc1nc2cc(Cl)c(N(C)C(=O)/C=C/CN(C)C)cc2n2cncc12 CHEMBL1916897 IC50 2.6 nM
Cc1c(-c2ccc(C(N)=O)c3[nH]c4cc(C(C)(C)O)ccc4c23)cccc1-n1cnc2ccccc2c1=O CHEMBL3918580 IC50 2.6 nM
Cc1c(-c2c(Cl)cc(C(N)=O)c3[nH]c4c(c23)CC[C@@H](C(C)(C)O)C4)cccc1-n1c(=O)c2cccc(F)c2n(C)c1=O CHEMBL3944049 IC50 2.6 nM
Cc1c(-c2ccc(C(N)=O)c3[nH]c4cc(C(C)(C)O)ccc4c23)cccc1-n1c(=O)c2ccccc2n(C)c1=O CHEMBL3941224 IC50 2.6 nM
CN1CCC(c2ccc(Nc3nc(-c4cc(F)cc(N5CCc6c(sc7c6CC(C)(C)C7)C5=O)c4CO)cn(C)c3=O)cc2)CC1 CHEMBL3670107 IC50 2.6 nM
N#C/C(=C\C1CC1)C(=O)N1CCCC1Cn1nc(-c2ccc(Oc3ccccc3)cc2)c2c(N)ncnc21 CHEMBL4114773 IC50 2.6 nM
C=CC(=O)N1CC(C2CCNc3c(C(N)=O)c(-c4ccc(OCc5ccccc5)cc4)nn32)C1 CHEMBL3894176 IC50 2.6 nM
Nc1nccn2c([C@H]3CC[C@@H]4CCOC(=O)N4C3)nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3)c12 CHEMBL3917607 IC50 2.6 nM
CN1CCC(Oc2ccc(-c3cc4c(-c5cccc(N6CCOc7cc(C8CC8)ccc7C6=O)c5CO)ncnc4[nH]3)cc2)CC1 CHEMBL3900184 IC50 2.6 nM
N#CN1CCC[C@@H](n2nc(-c3ccc(Oc4cccc(C(F)(F)F)n4)cc3)c(C(N)=O)c2N)C1 CHEMBL4456974 IC50 2.6 nM
CN(C)C/C=C/C(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)n[nH]c(=O)c32)C1 CHEMBL4758840 IC50 2.6 nM
Cn1cc(Nc2nccc(-c3ccc4c(c3)CCCCC4NC(=O)c3nnc(C(C)(C)C)n3C)n2)cn1 CHEMBL5093905 IC50 2.6 nM
Nc1nc(-c2cccc(-n3ccc4cc(C5CC5)cc(F)c4c3=O)c2CO)c2cc(C3=CCCCC3)[nH]c2n1 CHEMBL5082144 IC50 2.6 nM
Cc1cc(Nc2cc(-c3ccnc(-n4ncc5cc(C(C)(C)C)cc(F)c5c4=O)c3CO)cn(C)c2=O)nn1C CHEMBL5177238 IC50 2.6 nM
CC#CC(=O)N1CCC[C@H]1c1nc(-c2ccc(C(=O)Nc3ccccn3)cc2)c2c(N)nccn12 CHEMBL3707348 Kd 2.6 nM
Cc1c(-c2ccc(C(N)=O)c3[nH]c4c(c23)CC[C@H](C(C)(C)O)C4)cccc1-n1c(=O)c2cccc(F)c2n(C)c1=O CHEMBL3976719 IC50 2.7 nM
Cn1ncc2c1CCC[C@@H]2n1nc(-c2ccc(C(=O)Nc3cc(C(F)(F)F)ccn3)cc2)c2c(N)ncnc21 CHEMBL3948238 IC50 2.7 nM
C=CC(=O)Nc1ccccc1C1CCNc2c(C(N)=O)c(-c3ccc(OCCOC)cc3)nn21 CHEMBL3890068 IC50 2.7 nM
C=CC(=O)Nc1cccc(-c2c[nH]c3c(C(N)=O)c(-c4ccc(Oc5ccccc5)cc4)nn23)c1 CHEMBL3924160 IC50 2.7 nM
C=CC(=O)Nc1cc(Cl)ccc1C1CCNc2c(C(N)=O)c(-c3ccc(OCC4CC4)cc3)nn21 CHEMBL3985149 IC50 2.7 nM
C=CC(=O)Nc1ccccc1C1CCNc2c(C(N)=O)c(-c3cccc(OC)c3)nn21 CHEMBL3918154 IC50 2.7 nM
COc1cc(C(=O)Nc2cc(C(F)(F)F)n(C)n2)ccc1-c1nc([C@@H]2CC[C@H]3CCC(=O)N3C2)n2ccnc(N)c12 CHEMBL4107901 IC50 2.7 nM
COc1cc(C(=O)Nc2cc(C(F)(F)F)ccn2)ccc1-c1nc([C@@H]2CC[C@H]3CCC(=O)N3C2)n2c(C(F)(F)F)cnc(N)c12 CHEMBL4114465 IC50 2.7 nM
NC(=O)c1c(-c2ccc(Oc3ccc(F)cc3F)cc2)nn([C@@H]2CCCN(C(=O)/C=C/CF)C2)c1N CHEMBL4556666 IC50 2.7 nM
Cn1cc(-c2nc3c(-c4ccc(C5(NC(=O)c6nc(C(C)(C)C)no6)CC5)cc4)ccnc3[nH]2)cn1 CHEMBL4855916 IC50 2.7 nM
C=CC(=O)N1CCCC[C@H]1c1nc(-c2ccc(C(=O)Nc3cc(C(F)(F)F)ccn3)cc2)c(C(N)=O)n1N CHEMBL4864983 IC50 2.7 nM
C=CC(=O)Nc1cccc(-n2c(=O)c(-c3ccccc3)nc3cnc(Nc4ccc(OCCOC)cc4)nc32)c1 CHEMBL5076283 IC50 2.7 nM
C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(NC(=O)c4ccc(C(C)(C)C)cc4)c4c3OCO4)c3c(N)ncnc32)C1 CHEMBL5394800 IC50 2.7 nM
Cn1cc(-c2cc(F)cc(N3CCn4c(cc5c4CCCC5)C3=O)c2CO)cc(Nc2ccc(C3CCN(C4COC4)CC3)cn2)c1=O CHEMBL3670096 IC50 2.8 nM
CCN1CCc2nc(Nc3cc(-c4cc(F)cc(N5CCn6c(cc7c6CC(C)(C)C7)C5=O)c4CO)cn(C)c3=O)ccc2C1 CHEMBL3670113 IC50 2.8 nM
N#C/C(=C\C1CC1)C(=O)N1CCC[C@H]1Cn1nc(-c2ccc(Oc3ccccc3)c(F)c2)c2c(N)ncnc21 CHEMBL3901377 IC50 2.8 nM
C=CC(=O)N[C@H]1CCc2c(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc3n2C1 CHEMBL4214872 IC50 2.8 nM
C=CC(=O)NC1Cn2c(c(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1=C CHEMBL4217006 IC50 2.8 nM
C=CC(=O)N[C@H]1CCN(c2ccc(C(N)=O)c(Nc3ccc(C(=O)N4CC(C)OC(C)C4)cc3)n2)C1 CHEMBL4285083 IC50 2.8 nM
CN1CCN(c2ccc3c(C(N)=O)cn(-c4cccc(-n5ncc6cc(C(C)(C)C)cc(F)c6c5=O)c4CO)c3n2)CC1 CHEMBL3652672 IC50 2.83 nM
C=CC(=O)Nc1cccc(Nc2nc(Nc3ccc(OCC(=O)N(CCOC)CCOC)cc3)ncc2Cl)c1 CHEMBL4074951 IC50 2.83 nM
O=C1c2c(F)cc(C3CC3)cc2OCCN1c1cccc(-c2ccnc3[nH]c(-c4ccc(OCCN5CCOCC5)cn4)cc23)c1CO CHEMBL3912688 IC50 2.9 nM
C=CC(=O)Nc1ccccc1C1CCNc2c(C(N)=O)c(-c3cc(F)c(F)c(Cl)c3)nn21 CHEMBL3982878 IC50 2.9 nM
C=CC(=O)Nc1cccc(Oc2ncnc(N)c2-c2ccc(Oc3ccccc3)cc2)c1 CHEMBL4528630 IC50 2.9 nM
C=CC(=O)Nc1cccc(Nc2nc(Nc3ccc4c(c3)B(O)OC4)ncc2C(F)(F)F)c1 CHEMBL4648837 IC50 2.9 nM
C#CC(=O)N1CCC(c2cnn3c(C(N)=O)c(-c4ccc(Oc5ccccc5)cc4)[nH]c23)C1 CHEMBL4875332 IC50 2.9 nM
CC(C)/C=C(\C#N)C(=O)N[C@H](C)Cn1nc(-c2ccc(Oc3ccccc3)cc2F)c2c(N)ncnc21 CHEMBL4114703 IC50 2.9 nM
C=CC(=O)N(C)CCOc1cnccc1-c1ccc(CN2CCN(C(C)C)CC2=O)c(C)c1 CHEMBL5189311 IC50 2.9 nM
NC(=O)[C@H]1CCN(c2ncnc([N+](=O)[O-])c2F)C[C@@H]1N1CCCC(Nc2cc(Cl)cc(C(F)(F)F)c2)C1=O CHEMBL5269771 IC50 2.9 nM
C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(NC(=O)c4ccc(C#N)cc4)c4c3OCO4)c3c(N)ncnc32)C1 CHEMBL5431720 IC50 2.9 nM
Cc1cc(F)ccc1Nc1nc2ccc(N(C)C(=O)/C=C/CN(C)C)cc2n2cncc12 CHEMBL1916881 IC50 2.96 nM
CN1CCN(c2ccc(Nc3cc(-c4cccc(-n5ncc6cc(C(C)(C)C)cc(F)c6c5=O)c4CO)cn(C)c3=O)nc2)CC1 CHEMBL3358346 IC50 3.0 nM
CN1CCN(C(=O)c2ccc3c(c2)[nH]c2c(C(N)=O)ccc(-c4cccc(NC(=O)c5ccc(N(C)C)cc5)c4F)c23)CC1 CHEMBL3622193 IC50 3.0 nM
Cc1c(-c2cc(Nc3cc4n(n3)CCN(C)C4)c(=O)[nH]n2)ccc(F)c1NC(=O)c1cc2ccccc2s1 CHEMBL3746293 IC50 3.0 nM
CN1CCN(C)C(c2ccc(Nc3nc(-c4ccc(F)c(NC(=O)c5cc6c(s5)CCCC6)c4F)cn(C)c3=O)cc2)C1=O CHEMBL3745934 IC50 3.0 nM
Cn1cc(-c2cccc(N3CCc4c(sc5c4CCCC5)C3=O)c2CO)cc(Nc2cc(C3CC3)n[nH]2)c1=O CHEMBL3670091 IC50 3.0 nM
CN(C)CCOc1ccc(Nc2cc(-c3cc(F)cc(N4CCc5c(sc6c5CC(C)(C)C6)C4=O)c3CO)cn(C)c2=O)nc1 CHEMBL3670124 IC50 3.0 nM
Nc1n[nH]c2cc(C3CCCN(C(=O)Nc4ccccc4)C3)nc(-c3ccc(Oc4ccccc4)cc3)c12 CHEMBL3657236 IC50 3.0 nM
CN(C)C(=O)Cn1ccc(Nc2cc3[nH]nc(N)c3c(-c3ccc(Oc4ccccc4)cc3)n2)n1 CHEMBL3657241 IC50 3.0 nM
Cc1c(-c2cc(Nc3cc(C)n(C)n3)c(=O)[nH]n2)cccc1N1Cc2cc(C(C)(C)C)sc2C1=O CHEMBL3699640 IC50 3.0 nM
N#C/C(=C\C1CC1)C(=O)N1CCC[C@@H]1Cn1nc(-c2ccc(Oc3c(F)cccc3F)cc2F)c2c(N)ncnc21 CHEMBL4114665 IC50 3.0 nM
N#C/C(=C\C1CC1)C(=O)N1CC(F)(F)C[C@H]1Cn1nc(-c2ccc(Oc3ccccc3)cc2F)c2c(N)ncnc21 CHEMBL3922830 IC50 3.0 nM
CC(C)(N)/C=C(\C#N)C(=O)N1CCCC(n2nc(-c3ccc(Oc4ccccc4)cc3F)c3c(N)ncnc32)C1 CHEMBL4114772 IC50 3.0 nM
CC(C)C(C)(C)/C=C(\C#N)C(=O)N1CCC[C@H]1Cn1cc(-c2ccc(Oc3ccccc3)cc2)c2c(N)ncnc21 CHEMBL3918201 IC50 3.0 nM
Cc1c(NC(=O)c2ccc3c(C)c[nH]c3c2)cc(F)cc1-c1ncnc2[nH]c(C3=CCN(C(=O)N(C)C)CC3)cc12 CHEMBL3914504 IC50 3.0 nM
Cc1c(NC(=O)c2ccc(N3CCCCC3)cc2)cc(F)cc1-c1ncnc2[nH]c(C3=CCN(C(=O)N(C)C)CC3)cc12 CHEMBL3930926 IC50 3.0 nM
C=C(C)c1ccc(C(=O)Nc2cc(F)cc(-c3ncnc4[nH]c(C5=CCN(C(=O)N(C)C)CC5)cc34)c2C)cc1 CHEMBL3919531 IC50 3.0 nM
CC(=O)OCC(=O)N1CC=C(c2cc3c(-c4cc(F)cc(NC(=O)c5ccc(C6CC6)cc5)c4C)ncnc3[nH]2)CC1 CHEMBL3939270 IC50 3.0 nM
Cc1c(NC(=O)N2Cc3ccc(F)cc3C2)cc(F)cc1-c1ncnc2[nH]c(C3=CCN(C(=O)N(C)C)CC3)cc12 CHEMBL3932096 IC50 3.0 nM
CN1CCN(Cc2ccc(-c3cc4c(-c5cccc(N6CCOc7cc(C8CC8)ccc7C6=O)c5CO)ccnc4[nH]3)cc2)CC1 CHEMBL3967663 IC50 3.0 nM
CN1CCOC(c2ccc(-c3cc4c(-c5cccc(N6CCOc7cc(C8CC8)ccc7C6=O)c5CO)ccnc4[nH]3)cc2)C1 CHEMBL3956789 IC50 3.0 nM
CN1CCC(c2ccc(-c3cc4c(-c5cccc(-n6ccc7cc(C8CC8)ccc7c6=O)c5CO)ncnc4[nH]3)cc2)CC1 CHEMBL3892930 IC50 3.0 nM
CCN1CCC(n2cc(-c3cc4c(-c5cccc(-n6ncc7cc(C8CC8)ccc7c6=O)c5CO)ncnc4[nH]3)cn2)CC1 CHEMBL3905596 IC50 3.0 nM
O=C1c2ccc(C3CC3)cc2OCCN1c1cccc(-c2ccnc3[nH]c(-c4cnn(C5COC5)c4)cc23)c1CO CHEMBL3960244 IC50 3.0 nM
O=C1c2ccc(C3CC3)cc2OCCN1c1cccc(-c2ccnc3[nH]c(-c4ccc(CN5CCN(C6CC6)CC5)cn4)cc23)c1CO CHEMBL3957625 IC50 3.0 nM
CS(=O)(=O)N1CCN(Cc2ccc(-c3cc4c(-c5cccc(N6CCOc7cc(C8CC8)ccc7C6=O)c5CO)ccnc4[nH]3)nc2)CC1 CHEMBL3958922 IC50 3.0 nM
CN1CCN(c2ccc(-c3cc4c(-c5cccc(N6CCOc7cc(C8CC8)ccc7C6=O)c5CO)ccnc4[nH]3)nc2)CC1 CHEMBL3963872 IC50 3.0 nM
C=CC(=O)N1CCC2(CCNc3c(C(N)=O)c(-c4ccc(Oc5ccccc5)cc4)nn32)CC1 CHEMBL3939197 IC50 3.0 nM
CN1CC[C@H]2CC[C@H](c3nc(-c4ccc(C(=O)Nc5cc(C(F)(F)F)ccn5)cc4)c4c(N)nccn34)CN2C1=O CHEMBL3908219 IC50 3.0 nM
C=CC(=O)N1CCC(Oc2cc3c(Nc4ccc(Cl)c(Cl)c4F)ncnc3cc2OC)CC1 CHEMBL3545154 Kd apparent 3.0 nM
CC(C)[C@]1(C(=O)O)CCC[C@@H](c2nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3)c3c(N)nccn23)C1 CHEMBL4084927 IC50 3.0 nM
O=c1c2c(F)cc(C3CC3)cc2ccn1-c1cccc(-c2ccnc3[nH]c(C4=CCNCC4)cc23)c1CO CHEMBL4101864 IC50 3.0 nM
O=c1c2c(F)cc(C3CC3)cc2ccn1-c1cccc(-c2ccnc3[nH]c(C4=CCN(C5COC5)CC4)cc23)c1CO CHEMBL4079989 IC50 3.0 nM
Cn1cc(-c2cccc(N3Cc4cc(C(C)(C)C)sc4C3=O)c2CO)cc(Nc2ccncn2)c1=O CHEMBL4067714 IC50 3.0 nM
Cn1cc(-c2cccc(N3Cc4cc(C(C)(C)C)ccc4C3=O)c2CO)cc(Nc2ccncn2)c1=O CHEMBL4077625 IC50 3.0 nM
CN1CCN(c2ccc(Nc3cc(-c4cccc(N5CCc6c(sc7c6CC(C)(C)C7)C5=O)c4CO)cn(C)c3=O)nc2)CC1 CHEMBL4080943 IC50 3.0 nM
C=CC(=O)N[C@@H]1CCc2c(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc3n2C1 CHEMBL4211579 IC50 3.0 nM
Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)cn2C[C@H]1CCCN1C[C@@H]1CO1 CHEMBL4525187 IC50 3.0 nM
Cc1c(-c2ccc(C(N)=O)c3[nH]c4cc(C(C)(C)O)ccc4c23)cccc1N1CCc2ccccc2C1=O CHEMBL4465380 IC50 3.0 nM
Cc1c(-c2ccc(C(N)=O)c3[nH]c4cc(CO)ccc4c23)cccc1-n1cnc2ccccc2c1=O CHEMBL4550390 IC50 3.0 nM
Cc1cc(-c2ncnc3[nH]ccc23)ccc1CNC(=O)c1cnc(C(C)(C)C)s1 CHEMBL4740150 IC50 3.0 nM
Cn1cc(Nc2nccc(-c3ccc4c(c3)CCCCC4NC(=O)c3cnc(C(C)(C)C)nc3)n2)cn1 CHEMBL5083788 IC50 3.0 nM
O=C(N[C@@H]1CCCN(c2ncnc3[nH]ccc23)C1)[C@H](Nc1cc(F)cc(Cl)c1)C1CC1 CHEMBL5205957 Kd 3.0 nM
CC(C)(N)/C=C(\C#N)C(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3F)c3c(N)ncnc32)C1 CHEMBL5188669 IC50 3.0 nM
Cc1cc(-c2ccnc(Nc3cnn(C)c3)n2)ccc1CN1CCN(CC2CCC2)CC1=O CHEMBL5204655 IC50 3.0 nM
Cc1cc(-c2ccnc(Nc3cnn(C)c3)n2)ccc1CN1CCN(CC(C)C)CC1=O CHEMBL5170218 IC50 3.0 nM
Cc1cc(-c2ccnc(Nc3cnn(CCO)c3)n2)ccc1CN1CCN(CC(C)C)CC1=O CHEMBL5169775 IC50 3.0 nM
O=C(CNc1cc(F)cc(Cl)c1)N1CC[C@H]2CCN(c3ncnc4[nH]ccc34)[C@H]2C1 CHEMBL5268773 IC50 3.0 nM
CC#CC(=O)NC1CCC[C@@H]1c1nc(-c2ccc(C(=O)Nc3ccccn3)cc2)c2c(N)nccn12 CHEMBL5276925 IC50 3.0 nM
N#C/C(=C\C1CC1)C(=O)N1CCC[C@@H](n2nc(-c3ccc(NC(=O)c4ccccc4)c4c3OCO4)c3c(N)ncnc32)C1 CHEMBL5438302 IC50 3.0 nM
CC1(/C=C(\C#N)C(=O)N2CCC[C@H](n3nc(-c4ccc(Oc5ccccc5)cc4F)c4c(N)ncnc43)C2)COC1 CHEMBL3982962 IC50 3.1 nM
O=C(CN1CCC1)N1CC=C(c2cc3c(-c4cccc(N5CCOc6cc(C7CC7)cc(F)c6C5=O)c4CO)ccnc3[nH]2)CC1 CHEMBL3972631 IC50 3.1 nM
O=C1c2c(F)cc(C3CC3)cc2OCCN1c1cccc(-c2ccnc3[nH]c(-c4ccc(OCCN5CCC5)cn4)cc23)c1CO CHEMBL3944128 IC50 3.1 nM
CC1(/C=C(\C#N)C(=O)N2CCC[C@@H](n3nc(-c4ccc(Oc5ccccc5)cc4F)c4c(N)ncnc43)C2)COC1 CHEMBL3702827 IC50 3.1 nM
CCOc1cc(C(=O)Nc2cc(C(F)(F)F)n(C)n2)ccc1-c1nc([C@@H]2CC[C@H]3CCC(=O)N3C2)n2c(F)cnc(N)c12 CHEMBL4115382 IC50 3.1 nM
O=C1c2c(F)cc(C3CC3)cc2OCCN1c1cccc(-c2ccnc3[nH]c(C4=CCN(C5COC5)CC4)cc23)c1CO CHEMBL3966346 IC50 3.1 nM
C=CC(=O)N[C@@H]1Cn2c(c(-c3ccc(C(=O)NCc4ccccn4)cc3)c3c(N)ncnc32)C1=C CHEMBL4208616 IC50 3.1 nM
C=CC(=O)N1CC[C@H]1COc1c(N)ncnc1-c1cc(F)cc(NC(=O)c2ccc(C3CC3)cc2F)c1C CHEMBL4576902 IC50 3.1 nM
C=CC(=O)Nc1cccc(-n2c(=O)c(-c3ccccc3)nc3cnc(Nc4ccc(OC)cc4)nc32)c1 CHEMBL5069689 IC50 3.1 nM
CC#CC(=O)N1CCC[C@H]1Cn1nc(-c2ccc(Oc3ccccc3)cc2)c2c(N)ncnc21 CHEMBL3905432 IC50 3.14 nM
Cn1cc(-c2cccc(NC(=O)c3ccc(C(C)(C)C)cc3)c2CO)cc(Nc2ccc(C(=O)N3CCOCC3)cn2)c1=O CHEMBL2001584 pKi 3.162 nM
Cc1c(NC(=O)c2ccc(C(C)(C)C)cc2)cccc1-c1cn(C)c(=O)c(Nc2ccc(C(=O)NCCCNC(=S)Nc3ccc(-c4c5ccc(=O)cc-5oc5cc(O)ccc45)c(C(=O)O)c3)cc2)n1 CHEMBL3400826 IC50 3.2 nM
CC(C)(C)c1cc(F)c2c(=O)n(-c3cccc(-n4cc(C(N)=O)c5cccnc54)c3CO)ncc2c1 CHEMBL3649461 IC50 3.2 nM
N#C/C(=C\C1CC1)C(=O)N1CCC[C@H]1Cn1nc(-c2ccc(Oc3cc(F)cc(F)c3)cc2F)c2c(N)ncnc21 CHEMBL3984974 IC50 3.2 nM
Cn1cc2c(n1)CCC[C@H]2n1nc(-c2ccc(C(=O)Nc3cc(C(F)(F)F)ccn3)cc2)c2c(N)ncnc21 CHEMBL4114231 IC50 3.2 nM
CCn1ncc2c1CCC[C@H]2n1nc(-c2ccc(C(=O)Nc3cc(C(F)(F)F)ccn3)cc2)c2c(N)ncnc21 CHEMBL4114902 IC50 3.2 nM
C=CC(=O)Nc1ccccc1C1CCNc2c(C(N)=O)c(-c3ccc(F)c(F)c3)nn21 CHEMBL3900591 IC50 3.2 nM
C=CC(=O)Nc1ccccc1C1CCNc2c(C(N)=O)c(-c3ccc(OC)c(OC)c3)nn21 CHEMBL3930626 IC50 3.2 nM
CCOCCOc1cc(C(=O)Nc2cc(C(F)(F)F)ccn2)ccc1-c1nc([C@@H]2CC[C@H]3CCC(=O)N3C2)n2ccnc(N)c12 CHEMBL4110969 IC50 3.2 nM
C=CC(=O)Nc1cc(-n2c(=O)ccc3cnc4ccc(-c5ccc(NS(C)(=O)=O)cc5)cc4c32)ccc1C CHEMBL4091991 Ki 3.2 nM
C=CC(=O)N1CCC[C@@H](n2cc(C(N)=O)c(-c3ccc(Oc4ccccc4)cc3)n2)C1 CHEMBL4456912 IC50 3.2 nM
Cn1cc(-c2ccnc(-n3ncc4cc(C(C)(C)C)cc(F)c4c3=O)c2CO)cc(NC(=O)[C@H]2C[C@H]2F)c1=O CHEMBL4648439 IC50 3.2 nM
CC1(C(=O)N2CCC[C@@H](c3nc(-c4ccc(C(=O)Nc5nccs5)cc4F)c4c(N)nccn34)C2)COC1 CHEMBL4784093 IC50 3.2 nM
C#CC(=O)N1CC(c2cnn3c(C(N)=O)c(-c4ccc(Oc5ccccc5)cc4)[nH]c23)C1 CHEMBL4863088 IC50 3.2 nM
CC(C)/C=C(\C#N)C(=O)N[C@@H](C)Cn1nc(-c2ccc(Oc3ccccc3)cc2F)c2c(N)ncnc21 CHEMBL3947620 IC50 3.2 nM
CN1CCC(c2ccc(Nc3cc(-c4cc(F)cc(N5CCc6c(sc7c6CCCC7)C5=O)c4CO)cn(C)c3=O)nc2)C1 CHEMBL3670135 IC50 3.3 nM
N#C/C(=C\C1CC1)C(=O)N1CCC[C@@H](n2cc(-c3ccc(Oc4ccccc4)cc3F)c3c(N)ncnc32)C1 CHEMBL4109432 IC50 3.3 nM
Nc1nccn2c([C@@H]3CC[C@H]4CCC(=O)N4C3)nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)nc3)c12 CHEMBL4110723 IC50 3.3 nM
CC(=O)N1CC2(C1)CN(c1ccc(Nc3cc(-c4ccnc(N5CCn6c(cc7c6CC(C)(C)C7)C5=O)c4CO)cn(C)c3=O)nc1)C2 CHEMBL4071754 Ki 3.3 nM
COCCC(=O)N1CCO[C@@H](c2nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3)c3c(N)nccn23)C1 CHEMBL4097247 IC50 3.3 nM
C=C1c2c(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc3n2C[C@@H]1NC(=O)C#CC CHEMBL4215249 IC50 3.3 nM
C=CC(=O)NC1CCCN(c2ccc(C(N)=O)c3[nH]c(C)c(C)c23)C1 CHEMBL4644786 IC50 3.3 nM
C=CC(=O)N1CCC(Nc2ccc(C(N)=O)c3[nH]c(C)c(C)c23)CC1 CHEMBL4639092 IC50 3.3 nM
Cc1ccc(F)cc1Nc1nc2ccc(N(C)C(=O)/C=C/CN(C)C)cc2n2cncc12 CHEMBL1916880 IC50 3.33 nM
CC(C)N(C)Cc1ccc(Nc2cc(-c3cc(F)cc(N4CCc5c(sc6c5CCCC6)C4=O)c3CO)cn(C)c2=O)nc1 CHEMBL3670106 IC50 3.4 nM
CN(C)CCN(C)c1ccc(Nc2cc(-c3cc(F)cc(N4CCc5c(sc6c5CCCC6)C4=O)c3CO)cn(C)c2=O)nc1 CHEMBL3670115 IC50 3.4 nM
COc1nccc(Nc2cc(-c3cc(F)cc(N4CCn5c(cc6c5CC(C)(C)C6)C4=O)c3CO)cn(C)c2=O)n1 CHEMBL3670128 IC50 3.4 nM
O=C1c2c(F)cc(C3CC3)cc2OCCN1c1cccc(-c2ccnc3[nH]c(C4=CCN(C5CCOCC5)CC4)cc23)c1CO CHEMBL3951652 IC50 3.4 nM
CC1(C(=O)N2CCC(c3nc(-c4ccc(C(=O)Nc5cc(C(F)(F)F)ccn5)cc4)c4c(N)nccn34)CC2)COC1 CHEMBL4078497 IC50 3.4 nM
C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(NC(=O)c4ccc(OC)c(OC)c4)c4c3OCO4)c3c(N)ncnc32)C1 CHEMBL5436699 IC50 3.4 nM
Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)nn2[C@H]1CC[C@@H](NC(=O)/C=C/CN2CCOCC2)CC1 CHEMBL3894102 IC50 3.48 nM
C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(NC(=O)c4ccccc4N(C)C)c4c3OCO4)c3c(N)ncnc32)C1 CHEMBL5440675 IC50 3.49 nM
CC(C)Oc1cc(-n2cnc3ccc(N[C@@H](C)c4ccc(F)cn4)nc32)n[nH]1 CHEMBL2151321 IC50 3.5 nM
Cc1c(NC(=O)c2ccc(N(C)C)cc2)cccc1-c1ccc(C(N)=O)c2[nH]c3cc(C(=O)N4CCN(C)CC4)ccc3c12 CHEMBL3622190 IC50 3.5 nM
CN1CCCC(F)(c2ccc(-c3cc4c(-c5cccc(N6CCOc7cc(C8CC8)ccc7C6=O)c5CO)ccnc4[nH]3)cc2)C1 CHEMBL3965546 IC50 3.5 nM
C=CC(=O)NC1(C2CCNc3c(C(N)=O)c(-c4ccc(Oc5ccccc5)cc4)nn32)CC1 CHEMBL3944698 IC50 3.5 nM
C=CC(=O)N[C@@H]1Cn2c(c(-c3ccc(Oc4ccc(OC(F)(F)F)cc4)cc3)c3c(N)ncnc32)C1=C CHEMBL4203064 IC50 3.5 nM
C=CC(=O)NCc1cccc(-c2ccc(C(N)=O)c3[nH]c4c(c23)CCC(C(C)(C)O)C4)c1 CHEMBL4249247 IC50 3.5 nM
C=CS(=O)(=O)NC1CCN(c2ccc(C(N)=O)c3[nH]c(C)c(C)c23)C1 CHEMBL4642103 IC50 3.5 nM
C=CC(=O)Nc1ccc2nccc(Oc3ccc(C(=O)Nc4ccccn4)cc3)c2c1 CHEMBL4745935 IC50 3.5 nM
CN1CCc2cc(-c3ccnc(Nc4cnn(C)c4)n3)ccc2[C@H](NC(=O)c2cn(C(C)(C)C)nn2)C1 CHEMBL5073995 IC50 3.5 nM
C=CC(=O)Nc1cccc(-n2c(=O)c(C)nc3cnc(Nc4ccc(OCCOC)cc4)nc32)c1 CHEMBL5087785 IC50 3.5 nM
CCN1CCn2nc(Nc3cc(-c4cc(F)cc(N5CCn6c(cc7c6CC(C)(C)C7)C5=O)c4CO)cn(C)c3=O)cc2C1 CHEMBL3670114 IC50 3.6 nM
CN(C)C(C)(C)/C=C(\C#N)C(=O)N1CCC[C@@H]1Cn1nc(-c2ccc(Oc3ccccc3)cc2F)c2c(N)ncnc21 CHEMBL4114808 IC50 3.6 nM
CC(=O)N1CC=C(c2cc3c(-c4cccc(N5CCOc6cc(C7CC7)cc(F)c6C5=O)c4CO)ccnc3[nH]2)CC1 CHEMBL3968064 IC50 3.6 nM
C=CC(=O)N1CC(Oc2c(N)ncnc2-c2cc(F)cc(NC(=O)c3ccc(C4CC4)cc3)c2C)C1 CHEMBL4463650 IC50 3.6 nM
C=CC(=O)N(C)CCCOc1c(N)ncnc1-c1cc(F)cc(NC(=O)c2ccc(C3CC3)cc2F)c1C CHEMBL4550284 IC50 3.6 nM
N#C/C(=C\C1CC1)C(=O)N1CCC[C@H]1Cn1cc(-c2ccc(Oc3ccccc3)cc2)c2c(N)ncnc21 CHEMBL3957855 IC50 3.7 nM
N#C/C(=C\C1CCCN1)C(=O)N1CCC[C@H]1Cn1nc(-c2ccc(Oc3ccccc3)cc2F)c2c(N)ncnc21 CHEMBL3980841 IC50 3.7 nM
Nc1nccn2c([C@H]3CC[C@@H]4C[C@@H](O)C(=O)N4C3)nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3)c12 CHEMBL3893811 IC50 3.7 nM
CCOc1cc(C(=O)Nc2cc(C(F)(F)F)ccn2)c(F)cc1-c1nc([C@@H]2CC[C@H]3CCC(=O)N3C2)n2c(F)cnc(N)c12 CHEMBL4110276 IC50 3.7 nM
C=CC(=O)N[C@@H]1Cn2c(c(-c3ccc(Oc4ccc(C(C)(C)C)cc4)cc3)c3c(N)ncnc32)C1=C CHEMBL4217820 IC50 3.7 nM
C=CC(=O)N1CCC(Oc2c(N)ncnc2-c2cc(F)cc(NC(=O)c3ccc(C4CC4)cc3F)c2C)CC1 CHEMBL4445790 IC50 3.7 nM
CN(C)C/C=C/C(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccc(F)cc4F)cc3)c(C(N)=O)c2N)C1 CHEMBL4572913 IC50 3.7 nM
CC1(C(=O)N2C[C@H](c3nc(-c4ccc(C(=O)Nc5cc(C(F)(F)F)ccn5)cc4F)c4c(N)nccn34)CC[C@@H]2C(F)(F)F)COC1 CHEMBL4753001 IC50 3.7 nM
C=CC(=O)Nc1cccc(Nc2nc(Nc3ccc(OCCOC)cc3)ncc2[S+](C)[O-])c1 CHEMBL3786656 IC50 3.76 nM
Cc1c(NC(=O)c2ccc(C(C)(C)C)cc2)cccc1-c1cn(C)c(=O)c(Nc2ccc(C(=O)N3CCOC(CNC(=S)Nc4ccc(-c5c6ccc(=O)cc-6oc6cc(O)ccc56)c(C(=O)O)c4)C3)cc2)n1 CHEMBL3402356 Kd 3.8 nM
Cc1c(NC(=O)c2ccc(F)cc2)cccc1-c1ccc(C(N)=O)c2[nH]c3cc(C(=O)N4CCN(C)CC4)ccc3c12 CHEMBL3622189 IC50 3.8 nM
CN1CCC(c2ccc(Nc3cc(-c4cc(F)cc(N5CCc6c(sc7c6CCCC7)C5=O)c4CO)cn(C)c3=O)nc2)CC1 CHEMBL3670097 IC50 3.8 nM
CN1CCN(C(C)(C)/C=C(\C#N)C(=O)N2CCC[C@H]2Cn2nc(-c3ccc(Oc4ccccc4)cc3F)c3c(N)ncnc32)CC1 CHEMBL3702834 IC50 3.8 nM
N#C/C(=C\C1CC1)C(=O)N1CCCC1Cn1nc(-c2ccc(Oc3cc(F)ccc3F)cc2)c2c(N)ncnc21 CHEMBL3940151 IC50 3.8 nM
CC1(O)CCC(n2cc(-c3cc4c(-c5cccc(N6CCOc7cc(C8CC8)ccc7C6=O)c5CO)ccnc4[nH]3)cn2)CC1 CHEMBL3967820 IC50 3.8 nM
NC(=O)c1c(-c2ccc(Oc3ccccc3)cc2)nn2c1NCCC2C1CCN(C(=O)/C=C/CN2CCCCC2)CC1 CHEMBL3939637 IC50 3.8 nM
Nc1ncc(C(F)(F)F)n2c([C@@H]3CC[C@H]4CCC(=O)N4C3)nc(-c3ccc(C(=O)Nc4cc(C5CC5)ccn4)cc3F)c12 CHEMBL4111707 IC50 3.8 nM
CC(C)(C)c1ccc2c(c1)CN(c1cccc(-c3nc(N)nc(Nc4ccc(N5CCOCC5)cc4)n3)c1CO)C2=O CHEMBL4208482 IC50 3.8 nM
C=CC(=O)N(C)C/C=C/c1c(N)ncnc1-c1cc(F)cc(NC(=O)c2ccc(C3CC3)cc2)c1C CHEMBL4559123 IC50 3.8 nM
Cn1cc(-c2ccnc(N3CCn4c(cc5c4CC(C)(C)C5)C3=O)c2CO)cc(NC(=O)[C@H]2C[C@H]2F)c1=O CHEMBL4644448 IC50 3.8 nM
CC#CC(=O)Nc1cc2c(Oc3ccc(C(=O)Nc4ccccn4)cc3)ccnc2cc1OC1CCOCC1 CHEMBL4791135 IC50 3.8 nM
CC(C)CC1(O)CN(C(=O)NC2CCCCc3cc(-c4ccnc(Nc5cnn(C)c5)n4)ccc32)C1 CHEMBL5093755 IC50 3.8 nM
CCCC#CC(=O)N1CCC([C@@H]2CCNc3c(C(N)=O)c(-c4ccc(Oc5ccccc5)cc4)nn32)CC1 CHEMBL3958870 IC50 3.9 nM
CC(=O)Oc1cc(C(=O)Nc2cc(C(F)(F)F)ccn2)ccc1-c1nc([C@@H]2CC[C@H]3CCC(=O)N3C2)n2ccnc(N)c12 CHEMBL4106583 IC50 3.9 nM
C=CC(=O)Nc1cccc(Oc2nc(Nc3ccc(N4CCOCC4)cc3)nc3[nH]cc(-c4ccncc4)c23)c1 CHEMBL4464404 IC50 3.9 nM
Cc1ccccc1Nc1nc2ccc(N(C)C(=O)/C=C/CN(C)C)cc2n2cncc12 CHEMBL1916718 IC50 3.99 nM
CCN1CCN(c2ccc(Nc3cc(-c4cccc(-n5ccc6cc(C7CC7)cc(F)c6c5=O)c4CO)cn(C)c3=O)nc2)CC1 CHEMBL3352876 IC50 4.0 nM
Cc1c(-c2cc(Nc3cc4n(n3)CCN(C)C4)c(=O)[nH]n2)ccc(F)c1NC(=O)c1cnc(C(C)(C)C)cn1 CHEMBL3746333 IC50 4.0 nM
Cc1c(-c2cc(Nc3cc4n(n3)CCN(C)C4)c(=O)[nH]n2)ccc(F)c1NC(=O)c1ccc(C(C)(C)C)cc1 CHEMBL3747417 IC50 4.0 nM
Cc1c(NC(=O)c2cc3ccccc3s2)cccc1-c1cc(Nc2cc3n(n2)CCN(C)C3)c(=O)[nH]n1 CHEMBL3746115 IC50 4.0 nM
CCN1CCN(c2ccc(Nc3cc(-c4cc(F)cc(N5CCc6c(sc7c6CCCC7)C5=O)c4CO)cn(C)c3=O)nc2)CC1 CHEMBL3670099 IC50 4.0 nM
CN(C)CCN(C)c1ccc(Nc2cc(-c3cc(F)cc(N4CCc5c(sc6c5CC(C)(C)C6)C4=O)c3CO)cn(C)c2=O)nc1 CHEMBL3670100 IC50 4.0 nM
CN1CCC(c2ccc(Nc3nc(-c4cc(F)cc(N5CCn6c(cc7c6CCCC7)C5=O)c4CO)cn(C)c3=O)cc2)CC1 CHEMBL3670111 IC50 4.0 nM
C=CC(=O)N1CCCC(c2cc3[nH]nc(N)c3c(-c3ccc(Oc4ccccc4)cc3)n2)C1 CHEMBL3657237 IC50 4.0 nM
CC(C)/C=C(\C#N)C(=O)N1CCC1Cn1nc(-c2ccc(Oc3ccccc3)cc2F)c2c(N)ncnc21 CHEMBL3702838 IC50 4.0 nM
CC#CC(=O)N1CC[C@]2(C1)C[C@H](n1nc(-c3ccc(Oc4ccccc4)cn3)c3c(N)ncnc31)C2 CHEMBL3647527 IC50 4.0 nM
Cc1c(-c2cc(Nc3cc(C4CC4)[nH]n3)c(=O)[nH]n2)cccc1N1Cc2cc(C(C)(C)C)sc2C1=O CHEMBL3699641 IC50 4.0 nM
N#C/C(=C\C1CC1)C(=O)N1CCC[C@@H]1Cn1nc(-c2ccc(Oc3ccccc3)cc2F)c2c(N)ncnc21 CHEMBL4114689 IC50 4.0 nM
CC(C)/C=C(\C#N)C(=O)N1CC(F)(F)C[C@@H]1Cn1nc(-c2ccc(Oc3ccccc3)cc2F)c2c(N)ncnc21 CHEMBL4115689 IC50 4.0 nM
CCN(CC)C(C)(C)/C=C(\C#N)C(=O)N1CCC[C@@H]1Cn1cc(-c2ccc(Oc3ccccc3)cc2)c2c(N)ncnc21 CHEMBL4114678 IC50 4.0 nM
Cc1c(NC(=O)c2ccc3c(c2)OCC3(C)C)cc(F)cc1-c1ncnc2[nH]c(C3=CCN(C(=O)N(C)C)CC3)cc12 CHEMBL3934649 IC50 4.0 nM
COCC(C)(C)c1ccc(C(=O)Nc2cc(F)cc(-c3ncnc4[nH]c(C5=CCN(C(=O)N(C)C)CC5)cc34)c2C)cc1 CHEMBL3909128 IC50 4.0 nM
COC(C)(C)c1ccc(C(=O)Nc2cc(F)cc(-c3ncnc4[nH]c(C5=CCN(C(=O)N(C)C)CC5)cc34)c2C)cc1 CHEMBL3982520 IC50 4.0 nM
Cc1c(NC(=O)c2ccc(C3CC3)cc2)cc(F)cc1-c1ncnc2[nH]c(C3=CCN(C(=O)CC#N)CC3)cc12 CHEMBL3926072 IC50 4.0 nM
CC(C)(C)c1ccc(C(=O)Nc2cccc(-c3ncnc4[nH]c(C5=CCC(O)CC5)cc34)c2CO)cc1 CHEMBL3920088 IC50 4.0 nM
CCN1CCN(Cc2ccc(-c3cc4c(-c5cccc(N6CCOc7cc(C8CC8)ccc7C6=O)c5CO)ccnc4[nH]3)cc2)CC1 CHEMBL3976070 IC50 4.0 nM
CN1CC(n2cc(-c3cc4c(-c5cccc(N6CCOc7cc(C8CC8)ccc7C6=O)c5CO)ccnc4[nH]3)cn2)C1 CHEMBL3969541 IC50 4.0 nM
CC(C)(O)CN1CC=C(c2cc3c(-c4cc(F)cc(N5CCOc6cc(C7CC7)ccc6C5=O)c4CO)ccnc3[nH]2)CC1 CHEMBL3940779 IC50 4.0 nM
O=C1c2c(F)cc(C3CC3)cc2OCCN1c1cccc(-c2ccnc3[nH]c(C4=CCN(C5CCOC5)CC4)cc23)c1CO CHEMBL3978618 IC50 4.0 nM
C=CC(=O)N1CCCC(n2cc(-c3cc4c(-c5cccc(N6CCOc7cc(C8CC8)cc(F)c7C6=O)c5CO)ncnc4[nH]3)cn2)C1 CHEMBL3895812 IC50 4.0 nM
C=CC(=O)Nc1cccc(-c2nc(Nc3ccc(N4CCOCC4)c(O)c3)ncc2Cl)c1 CHEMBL3940287 IC50 4.0 nM
Nc1nccn2c([C@H]3CC[C@@H]4CNCC(=O)N4C3)nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3)c12 CHEMBL3939414 IC50 4.0 nM
CCOc1cc(C(=O)Nc2cc(C(F)(F)F)n(C)n2)ccc1-c1nc([C@@H]2CC[C@H]3CCC(=O)N3C2)n2c(C(F)(F)F)cnc(N)c12 CHEMBL4111703 IC50 4.0 nM
C=CC(=O)N1CCC[C@H](n2c(=O)n(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1 CHEMBL3991931 Kd apparent 4.0 nM
Cn1cc(-c2ccnc(N3CCn4c(cc5c4CC(C)(C)C5)C3=O)c2CO)cc(Nc2ccc(N3CCN(CCC(F)(F)F)CC3)cn2)c1=O CHEMBL4079803 Ki 4.0 nM
Cn1cc(-c2cccc(N3CCNc4cc(C(C)(C)C)ccc4C3=O)c2CO)cc(Nc2ccncn2)c1=O CHEMBL4069030 IC50 4.0 nM
Cn1cc(-c2cccc(N3CCc4c(sc5c4CC(C)(C)C5)C3=O)c2CO)cc(Nc2ccc(N3CCN(C4COC4)CC3)cn2)c1=O CHEMBL3670139 IC50 4.0 nM
CN1CCN(c2ccc(Nc3cc(-c4cccc(N5CCn6c(cc7c6CCCC7)C5=O)c4CO)cn(C)c3=O)nc2)CC1 CHEMBL3670088 IC50 4.0 nM
CC(C)(C)/C=C(/C#N)C(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1 CHEMBL4167139 IC50 4.0 nM
CC(C)(C)c1ccc(C(=O)Nc2cccc(-c3nc(N)nc(Nc4ccc(N5CCOCC5)cc4)n3)c2CO)s1 CHEMBL4215004 IC50 4.0 nM
C=CC(=O)Nc1cccc(Nc2ncnc(N)c2-c2ccc(Oc3ccccc3)cc2)c1 CHEMBL4554990 IC50 4.0 nM
CC(C)(O)c1ccc2c(c1)[nH]c1c(C(N)=O)ccc(-c3cccc(-n4cnc5ccccc5c4=O)c3F)c12 CHEMBL3977725 IC50 4.0 nM
C=CC(=O)Nc1cccc(-n2c(=O)c(C3CCCCC3)nc3cnc(Nc4cccc(OCCOC)c4)nc32)c1 CHEMBL5085807 IC50 4.0 nM
C=CC(=O)Nc1cccc(-n2c(=O)c(C3CCCCC3)nc3cnc(Nc4cccc(N5CCN(C)CC5)c4)nc32)c1 CHEMBL5088574 IC50 4.0 nM
C[C@H]1CCN(c2ncnc3[nH]ncc23)C[C@@H]1NC(=O)[C@H](Nc1cc(F)cc(Cl)c1)C1CC1 CHEMBL5199196 IC50 4.0 nM
O=C1[C@H](Nc2cc(F)cc(Cl)c2)CCCN1[C@@H]1CCCN(c2ncnc3[nH]ccc23)C1 CHEMBL5169765 IC50 4.0 nM
CC(C)CN1CCN(Cc2ccc(-c3ccnc(Nc4cnn(CCO)c4)n3)cc2Cl)C(=O)C1 CHEMBL5170919 IC50 4.0 nM
CN1CCN(c2ccc(Nc3nc(-c4cccc(-n5ccc6cc(C7CC7)cc(F)c6c5=O)c4CO)cn(C)c3=O)nc2)CC1 CHEMBL5273455 IC50 4.0 nM
Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)nn2C1CCN(C(=O)/C=C/CN2CCOCC2)CC1 CHEMBL3982014 IC50 4.07 nM
CC(C)(C)c1cc(F)c2c(=O)n(-c3cccc(-n4cc(C(N)=O)c5ccccc54)c3CO)ncc2c1 CHEMBL3652650 IC50 4.1 nM
CC(C)(/C=C(\C#N)C(=O)N1CCC[C@H](n2nc(-c3ccc(Oc4ccccc4)cc3F)c3c(N)ncnc32)C1)N1CCC1 CHEMBL3950862 IC50 4.1 nM
CC(C)(/C=C(\C#N)C(=O)N1CCC1Cn1nc(-c2ccc(Oc3ccccc3)cc2F)c2c(N)ncnc21)N1CCOCC1 CHEMBL3702843 IC50 4.1 nM
CC(C)(/C=C(\C#N)C(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3F)c3c(N)ncnc32)C1)N1CCC1 CHEMBL3702828 IC50 4.1 nM
C=CC(=O)Nc1ccc2c(c1)CCCc1c(C(N)=O)c(-c3ccc(Oc4ccccc4)cc3)nn1-2 CHEMBL3949761 IC50 4.1 nM
Nc1nccn2c([C@H]3CC[C@@H]4C[C@H](O)C(=O)N4C3)nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3)c12 CHEMBL3929022 IC50 4.1 nM
C=CC(=O)N1CCN(c2ccc(C(N)=O)c(Oc3ccc(Oc4ccccc4)cc3)n2)CC1 CHEMBL4250200 IC50 4.1 nM
C=CC(=O)Nc1cccc(-n2c(=O)n(C)c3cnc(Nc4ccc(OCCOC)cc4)nc32)c1 CHEMBL3787191 IC50 4.11 nM
Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)nn2C[C@@H]1CCCN1C(=O)/C=C/CN1CCOCC1 CHEMBL3915538 IC50 4.15 nM
CC#CC(=O)N1CCC[C@@H]1Cn1nc(-c2ccc(Oc3ccccc3)cc2)c2c(N)ncnc21 CHEMBL4107879 IC50 4.16 nM
Cn1cc(-c2cc(F)cc(N3CCc4c(sc5c4CC(C)(C)C5)C3=O)c2CO)cc(Nc2ccc3c(n2)CCN(C2COC2)C3)c1=O CHEMBL3670109 IC50 4.2 nM
CN(C)CCOc1ccc(Nc2cc(-c3cc(F)cc(N4CCn5c(cc6c5CCCC6)C4=O)c3CO)cn(C)c2=O)nc1 CHEMBL3670125 IC50 4.2 nM
N#C/C(=C\C1CC1)C(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4cc(F)ccc4F)cc3)c3c(N)ncnc32)C1 CHEMBL4114704 IC50 4.2 nM
C=CC(=O)Nc1ccccc1C1CCNc2c(C(N)=O)c(-c3ccc(OC(F)(F)F)cc3)nn21 CHEMBL3906546 IC50 4.2 nM
C=CC(=O)Nc1ccccc1C1CCNc2c(C(N)=O)c(-c3ccc(C(F)(F)F)cc3)nn21 CHEMBL3954175 IC50 4.2 nM
CC1C=C(c2ccnc(-n3ccn4c5c(cc4c3=O)CCCC5)c2CO)C=C(Nc2ccc(N3CCN(C4COC4)CC3)cc2)C1=O CHEMBL4104307 Ki 4.2 nM
Nc1nc(Nc2ccc(N3CCOCC3)cc2)nc(-c2cccc(N3CCc4cc(C5CC5)ccc4C3=O)c2CO)n1 CHEMBL4204140 IC50 4.2 nM
C=CS(=O)(=O)N1CCC[C@@H](n2nc(C#CCOc3ccccc3)c3c(N)ncnc32)C1 CHEMBL4519813 IC50 4.2 nM
C=CC(=O)NC1CCN(c2ccc(C(N)=O)c3[nH]c(C)c(C)c23)C1 CHEMBL4646406 IC50 4.2 nM
C=CS(=O)(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)n[nH]c(=O)c32)C1 CHEMBL4752442 IC50 4.2 nM
Cc1c(NC(=O)c2ccc(C(C)(C)C)cc2)cccc1-c1cn(C)c(=O)c(Nc2ccc(C(=O)NCCCCNC(=S)Nc3ccc(-c4c5ccc(=O)cc-5oc5cc(O)ccc45)c(C(=O)O)c3)cc2)n1 CHEMBL3402353 IC50 4.3 nM
N#C/C(=C\C1CC1)C(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4c(F)cccc4F)cc3)c3c(N)ncnc32)C1 CHEMBL4114770 IC50 4.3 nM
CC#CC(=O)NCC1CCNc2c(C(N)=O)c(-c3ccc(Oc4ccccc4)cc3)nn21 CHEMBL3968870 IC50 4.3 nM
C=CC(=O)N[C@@H]1Cn2c(c(-c3ccc(C(=O)N[C@@H](COC)c4ccccn4)cc3)c3c(N)ncnc32)C1=C CHEMBL4203739 IC50 4.3 nM
C=C1c2c(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc3n2CC1NC(=O)/C=C/CN(C)C CHEMBL4203826 IC50 4.3 nM
Nc1nc(Nc2ccc(N3CCOCC3)cc2)nc(-c2cccc(-n3ncc4cc(C5CC5)ccc4c3=O)c2CO)n1 CHEMBL4209020 IC50 4.3 nM
N[C@H]1CC[C@@H](Nc2ncnc3[nH]cc(C(=O)c4ccc(Oc5ccccc5)cc4Cl)c23)CC1 CHEMBL5073639 IC50 4.3 nM
C=CC(=O)NCCNc1cccc(Nc2cc(-c3ccnc(N4CCn5c(cc6c5CC(C)(C)C6)C4=O)c3CO)cn(C)c2=O)n1 CHEMBL3917719 Ki 4.33 nM
N#C/C(=C\C1CC1)C(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4cccc(F)c4F)cc3)c3c(N)ncnc32)C1 CHEMBL4114699 IC50 4.4 nM
CC(C)/C=C(\C#N)C(=O)N1CCC[C@@H]1Cn1nc(-c2ccc(Oc3ccccc3)cc2F)c2c(N)ncnc21 CHEMBL4114732 IC50 4.4 nM
CC(=O)Nc1nccn2c([C@@H]3CC[C@H]4CCC(=O)N4C3)nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3O)c12 CHEMBL4106570 IC50 4.4 nM
C=CC(=O)N1CC[C@]2(C1)C[C@H](n1c(NC(=O)c3ccc(C(F)F)s3)nc3cc(CN[C@@H](C)C(C)(C)C)ccc31)C2 CHEMBL4206487 IC50 4.4 nM
C=CC(=O)N1C2CCC1CN(c1ccc(C(N)=O)c(Oc3ccc(Oc4ccccc4)cc3)n1)C2 CHEMBL4246399 IC50 4.4 nM
C=CC(=O)N1CCCC[C@H]1c1nc(-c2ccc(C(=O)Nc3cc(Br)ccn3)cc2)c(C(N)=O)n1N CHEMBL4878421 IC50 4.4 nM
CC(C)/C=C(/C#N)C(=O)N1CCC[C@@H]1Cn1nc(-c2ccc(Oc3ccccc3)cc2F)c2c(N)ncnc21 CHEMBL5203733 IC50 4.4 nM
CC1(C(=O)O)CCC(c2nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3)c3c(N)nccn23)CC1 CHEMBL4095276 IC50 4.5 nM
C=CC(=O)N1CC(Oc2c(N)ncnc2-c2cc(F)cc(NC(=O)c3ccc(C4CC4)cc3F)c2C)C1 CHEMBL4567040 IC50 4.5 nM
C=CC(=O)Nc1cccc(-n2c(=O)c(C(C)C)nc3cnc(Nc4ccc(OCCOC)cc4)nc32)c1 CHEMBL5077901 IC50 4.5 nM
C=CC(=O)N1CCC(Nc2ncnc3[nH]cc(C(=O)N4CC(Oc5ccccc5)C4)c23)C1 CHEMBL5171858 IC50 4.5 nM
Nc1nccn2c([C@H]3CC[C@H]4CC(O)C(=O)N4C3)nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3)c12 CHEMBL3964420 IC50 4.6 nM
Nc1nccn2c([C@@H]3CC[C@H]4CCC(=O)N4C3)nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3OC3CCC3)c12 CHEMBL4108745 IC50 4.6 nM
Nc1nccn2c([C@@H]3CC[C@H]4CCC(=O)N4C3)nc(-c3cc(F)c(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3Cl)c12 CHEMBL4110336 IC50 4.6 nM
CN1CC(c2ccc(Nc3cc(-c4cc(F)cc(N5CCn6c(cc7c6CC(C)(C)C7)C5=O)c4CO)cn(C)c3=O)nc2)C1 CHEMBL3670101 IC50 4.7 nM
CC(C)(/C=C(\C#N)C(=O)N1CCC[C@H]1Cn1nc(-c2ccc(Oc3ccccc3)cc2F)c2c(N)ncnc21)N1CCNCC1 CHEMBL3702835 IC50 4.7 nM
C=CC(=O)N(C)c1ccccc1C1CCNc2c(C(N)=O)c(-c3ccc(Oc4ccccc4)cc3)nn21 CHEMBL3897911 IC50 4.7 nM
C=CC(=O)Nc1ccccc1C1CCNc2c(C(N)=O)c(-c3ccccc3)nn21 CHEMBL3976076 IC50 4.7 nM
CC#CC(=O)N1CC(C2CCNc3c(C(N)=O)c(-c4ccc(Oc5ccccc5)cc4)nn32)C1 CHEMBL3910644 IC50 4.7 nM
C=CC(=O)Nc1cc(Nc2cc(-c3cccc(NC(=O)c4ccc(C(C)(C)C)cc4)c3C)cn(C)c2=O)ccc1C(=O)N1CCOCC1 CHEMBL4077123 EC50 4.7 nM
CN(C)c1ccc(C(=O)Nc2cccc(-c3nc(N)nc(Nc4ccc(N5CCOCC5)cc4)n3)c2CO)cc1 CHEMBL4209666 IC50 4.7 nM
C=CC(=O)Nc1cccc(Nc2nc(Nc3ccc4c(c3)B(O)OC4)ncc2Cl)c1 CHEMBL4647555 IC50 4.7 nM
CC#CC(=O)Nc1ccc2nccc(Oc3ccc(C(=O)Nc4ccccn4)cc3)c2c1 CHEMBL4800082 IC50 4.7 nM
CCC(=O)N1CCC[C@@H](n2nc(-c3ccc(Cc4ccccc4)cc3)c3c(N)ncnc32)C1 CHEMBL5197089 IC50 4.7 nM
C=CC(=O)Nc1cccc(N2C(=O)OCc3cnc(Nc4ccc(N5CCN(C)CC5)cc4OC)nc32)c1 CHEMBL5203118 IC50 4.7 nM
O=C(N1CC=C(c2cc3c(-c4cccc(-n5ccc6cc(C7CC7)cc(F)c6c5=O)c4CO)ncnc3[nH]2)CC1)N1CCOCC1 CHEMBL3402585 IC50 4.8 nM
N#C/C(=C\C1CC1)C(=O)NCCn1nc(-c2ccc(Oc3ccccc3)cc2)c2c(N)ncnc21 CHEMBL3981330 IC50 4.8 nM
C=CC(=O)N1CCC(C2CCNc3c(C(N)=O)c(-c4ccc(C)c(OC)c4)nn32)CC1 CHEMBL3918344 IC50 4.8 nM
Cc1cc(C(F)(F)F)cc(NC(=O)c2ccc(-c3nc([C@@H]4CC[C@H]5CCC(=O)N5C4)n4ccnc(N)c34)cc2)n1 CHEMBL4108285 IC50 4.8 nM
Cn1cc(-c2ccnc(-n3ncc4cc(C(C)(C)C)cc(F)c4c3=O)c2CO)cc(NC(=O)C2CC2)c1=O CHEMBL4641507 IC50 4.8 nM
C#CC(=O)N1CC(c2cnn3c(C(N)=O)c(-c4ccc(Oc5ccc(F)cc5)cc4)[nH]c23)C1 CHEMBL4853615 IC50 4.8 nM
C=CC(=O)Nc1cccc(-n2c(=O)c(C3CC3)nc3cnc(Nc4ccc(OCCOC)cc4)nc32)c1 CHEMBL5086054 IC50 4.8 nM
C=CC(=O)N(C)CCOc1cnccc1-c1ccc(CN2CCN(CCC)CC2=O)c(C)c1 CHEMBL5172575 IC50 4.8 nM
C=CC(=O)N1CCC[C@@H](NC(=O)c2sc3nccc4c3c2NC(=O)N4c2ccc(Oc3ccccc3)cc2C)C1 CHEMBL4853403 Ki 4.81 nM
Cc1ccccc1Nc1nc2cc(Cl)c(N(C)C(=O)/C=C/CN(C)C)cc2n2cncc12 CHEMBL1916895 IC50 4.83 nM
CN1CCn2nc(Nc3cc(-c4cc(F)cc(N5CCc6c(sc7c6CC(C)(C)C7)C5=O)c4CO)cn(C)c3=O)cc2C1 CHEMBL3670108 IC50 4.9 nM
Cn1cc(-c2cc(F)cc(N3CCc4c(sc5c4CCCC5)C3=O)c2CO)cc(Nc2ccc(C3CCN(C4COC4)CC3)cn2)c1=O CHEMBL3670131 IC50 4.9 nM
CC#CC(=O)N1CCC(c2cnn3c(C(N)=O)c(-c4ccc(Oc5ccccc5)cc4)[nH]c23)CC1 CHEMBL4878090 IC50 4.9 nM
C=CC(=O)Nc1cccc(Nc2nc(Nc3ccc(N(CCOC)CCOC)cc3)ncc2Cl)c1 CHEMBL4100369 IC50 4.94 nM
CN(C(=O)c1ccccc1)c1ccc2c(c1)[nH]/c(=N\C(=O)c1ccc(/C=C/c3ncc(N)cn3)s1)n2CCC(N)=O CHEMBL500517 IC50 5.0 nM
C=CC(=O)N1CCC[C@@H](n2nc(-c3cccc(C(=O)Nc4ccc(C(C)C)cc4)c3)c3c(N)ncnc32)C1 CHEMBL2179804 IC50 5.0 nM
C=CC(=O)Nc1cccc(Nc2ncc(NC(=O)c3cc(NC(=O)c4cccc(C(F)(F)F)c4)ccc3C)cn2)c1 CHEMBL3290142 IC50 5.0 nM
Cc1ccc(-c2cn(C)c(=O)c(Nc3ccc(C4C(=O)N(C)CCN4C)cc3)n2)c(Cl)c1NC(=O)c1cc2c(s1)CCCC2 CHEMBL3747742 IC50 5.0 nM
Cn1cc(-c2cc(F)cc(N3CCn4c(cc5c4CCCC5)C3=O)c2CO)cc(Nc2cc3n(n2)CCOC3)c1=O CHEMBL3670093 IC50 5.0 nM
Cn1cc(-c2cc(F)cc(N3CCc4c(sc5c4CCCC5)C3=O)c2CO)cc(Nc2ccc(N3CCOCC3)cn2)c1=O CHEMBL3670118 IC50 5.0 nM
Cc1c(-c2cc(Nc3cc(CN4CC(F)(F)C4)n(C)n3)c(=O)[nH]n2)cccc1N1Cc2cc(C(C)(C)C)sc2C1=O CHEMBL3699647 IC50 5.0 nM
N#C/C(=C\C1CC1)C(=O)N1CCC[C@H]1Cn1nc(-c2ccc(Oc3c(F)cccc3F)cc2F)c2c(N)ncnc21 CHEMBL3922858 IC50 5.0 nM
Cc1cc(Oc2ccccc2)ccc1-c1nn(C[C@@H]2CCCN2C(=O)/C(C#N)=C/C2CC2)c2ncnc(N)c12 CHEMBL4115679 IC50 5.0 nM
CCOC(C)(C)/C=C(\C#N)C(=O)N[C@H](C)Cn1nc(-c2ccc(Oc3ccccc3)cc2F)c2c(N)ncnc21 CHEMBL4114722 IC50 5.0 nM
Cc1c(NC(=O)c2cc3c(s2)CCC(C)C3)cc(F)cc1-c1ncnc2[nH]c(C3=CCN(C(=O)N(C)C)CC3)cc12 CHEMBL3908775 IC50 5.0 nM
Cc1c(NC(=O)c2ccc(C3(C(F)(F)F)CC3)cc2)cc(F)cc1-c1ncnc2[nH]c(C3=CCN(C(=O)N(C)C)CC3)cc12 CHEMBL3900123 IC50 5.0 nM
CN1CCN(c2ccc(-c3cc4c(-c5cccc(-n6ccc7cc(C8CC8)ccc7c6=O)c5CO)ncnc4[nH]3)cc2)CC1 CHEMBL3942801 IC50 5.0 nM
CN1CCC(n2cc(-c3cc4c(-c5cccc(-n6ccc7cc(C8CC8)ccc7c6=O)c5CO)ncnc4[nH]3)cn2)CC1 CHEMBL3953196 IC50 5.0 nM
CN1CCC(n2cc(-c3cc4c(-c5cccc(N6CCOc7cc(C8CC8)ccc7C6=O)c5CO)ccnc4[nH]3)cn2)CC1 CHEMBL3958477 IC50 5.0 nM
CN1CCCC(n2cc(-c3cc4c(-c5cccc(N6CCOc7cc(C8CC8)ccc7C6=O)c5CO)ncnc4[nH]3)cn2)C1 CHEMBL3898339 IC50 5.0 nM
CN1CC(Oc2ccc(-c3cc4c(-c5cccc(N6CCOc7cc(C8CC8)ccc7C6=O)c5CO)ncnc4[nH]3)cc2)C1 CHEMBL3962146 IC50 5.0 nM
CN1CCN(Cc2ccc(-c3cc4c(-c5cccc(N6CCOc7cc(C8CC8)ccc7C6=O)c5CO)ccnc4[nH]3)nc2)CC1 CHEMBL3922230 IC50 5.0 nM
C=CC(=O)N1CC2(CNc3c(C(N)=O)c(-c4ccc(Oc5ccccc5)cc4)nn32)C1 CHEMBL3977236 IC50 5.0 nM
Cn1cc(-c2cccc(N3CCOc4cc(C(C)(C)C)ccc4C3=O)c2CO)cc(Nc2ccncn2)c1=O CHEMBL4096404 IC50 5.0 nM
C=CC(=O)Nc1cccc(Oc2ccnc(N)c2-c2ccc(Oc3ccccc3)cc2)c1 CHEMBL4461455 IC50 5.0 nM
Cc1c(-c2ccc(C(N)=O)c3[nH]c4cc(C(=O)N5CCN(C)CC5)ccc4c23)cccc1N1Cc2ccccc2C1=O CHEMBL4567605 IC50 5.0 nM
Cc1c(-c2ccc(C(N)=O)c3[nH]c4cc(C(C)(C)O)ccc4c23)cccc1N1Cc2ccccc2C1=O CHEMBL4439761 IC50 5.0 nM
Cc1c(-c2ccc(C(N)=O)c3[nH]c4cc(C(C)(C)O)ccc4c23)cccc1-n1ccc2ccccc2c1=O CHEMBL4554269 IC50 5.0 nM
Cc1c(-c2ccc(C(N)=O)c3[nH]c4cc(C(C)(C)O)ccc4c23)cccc1-n1cnc2cccc(F)c2c1=O CHEMBL4473176 IC50 5.0 nM
C=CC(=O)N1CCC(c2c[nH]c3ncnc(-c4cc(F)cc(NC(=O)c5ccc(C6CC6)cc5)c4C)c23)C1 CHEMBL4740933 IC50 5.0 nM
Cc1cc(-c2ncnc3[nH]ccc23)ccc1CNC(=O)c1ccc(C(C)(C)C)cc1 CHEMBL4756023 IC50 5.0 nM
C=CC(=O)N1CCCC[C@H]1c1nc(-c2ccc(C(=O)Nc3cc(-c4ccc(F)cc4)ccn3)cc2)c(C(N)=O)n1N CHEMBL4863913 IC50 5.0 nM
O=C(N[C@H]1CN(c2ncnc3[nH]ncc23)CC[C@@H]1C(F)(F)F)[C@H](Nc1cc(F)cc(Cl)c1)C1CC1 CHEMBL5180755 IC50 5.0 nM
CC[C@@H](Nc1cc(Cl)cc(Cl)c1)C(=O)N[C@@H]1CCCN(c2ncnc3[nH]ccc23)C1 CHEMBL5183111 IC50 5.0 nM
CC(C)[C@@H](Nc1cc(Cl)cc(Cl)c1)C(=O)N[C@@H]1CCCN(c2ncnc3[nH]ccc23)C1 CHEMBL5198691 IC50 5.0 nM
O=C(N[C@@H]1CCCN(c2ncnc3[nH]ccc23)C1)[C@H](Nc1cc(Cl)cc(Cl)c1)C1CC1 CHEMBL5175032 Kd 5.0 nM
CN(c1ncnc2[nH]ccc12)[C@@H]1CCCN(C(=O)CNc2cc(Cl)cc(Cl)c2)C1 CHEMBL5276931 IC50 5.0 nM
CC1C(Nc2ncnc3[nH]ccc23)CCCN1C(=O)CNc1cc(Cl)cc(Cl)c1 CHEMBL5280787 IC50 5.0 nM
CN(C)C/C=C/C(=O)N(C)c1cc2c(cc1Cl)nc(Nc1ccccc1Cl)c1cncn12 CHEMBL1916896 IC50 5.03 nM
Cn1nc(-c2ccnc(-n3ncc4cc(C(C)(C)C)cc(F)c4c3=O)c2CO)cc(NC(=O)[C@@H]2C[C@@H]2F)c1=O CHEMBL4646964 IC50 5.1 nM
Cc1c(NC(=O)c2ccc(C(C)(C)C)cc2)cccc1-c1cn(C)c(=O)c(Nc2ccc(C(=O)N3CCN(CCCCCCNC(=O)CNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)cc2)n1 CHEMBL4754443 IC50 5.1 nM
CC#CC(=O)N1CCC[C@@H]1c1nc(-c2ccc(C(=O)Nc3ccccn3)cc2)c2c(N)nccn12 CHEMBL4747506 IC50 5.1 nM
Cc1c(NC(=O)c2ccc(C(C)(C)C)cc2)cccc1-c1ccnc2[nH]c(-c3ccc(C(=O)N4CCOCC4)cc3)nc12 CHEMBL4872106 IC50 5.1 nM
C=CC(=O)N1CCCC[C@H]1c1nc(-c2ccc(C(=O)Nc3cc(-c4ccccc4)ccn3)cc2)c(C(N)=O)n1N CHEMBL4863836 IC50 5.1 nM
CC#CC(=O)N1CCC[C@H]1n1nc(-c2ccc(C(=O)Nc3ccccn3)cc2)c2c(N)ncnc21 CHEMBL5187554 IC50 5.1 nM
CN1CCC(c2ccc(Nc3nc(-c4cc(F)cc(N5CCc6c(sc7c6CCCC7)C5=O)c4CO)cn(C)c3=O)cc2)CC1 CHEMBL3670110 IC50 5.2 nM
Cn1cc(-c2cccc(N3CCn4c(cc5c4CC(C)(C)C5)C3=O)c2CO)cc(Nc2ccc(N3CCN(C4COC4)CC3)cn2)c1=O CHEMBL3670138 IC50 5.2 nM
CC(C)(/C=C(\C#N)C(=O)N1CCC[C@H]1Cn1nc(-c2ccc(Oc3ccccc3)cc2F)c2c(N)ncnc21)CN1CCOCC1 CHEMBL3702853 IC50 5.2 nM
CN1CC[C@H]2CC[C@@H](c3nc(-c4ccc(C(=O)Nc5cc(C(F)(F)F)ccn5)cc4)c4c(N)nccn34)CN2C1=O CHEMBL4107322 IC50 5.2 nM
COc1cc(C(=O)Nc2ncc(C)s2)ccc1-c1nc([C@@H]2CC[C@H]3CCC(=O)N3C2)n2ccnc(N)c12 CHEMBL4113598 IC50 5.2 nM
CC#CC(=O)N(C)CCOc1c(N)ncnc1-c1cc(F)cc(NC(=O)c2ccc(C3CC3)cc2F)c1C CHEMBL4437701 IC50 5.2 nM
CC#CC(=O)N1CC[C@@H](n2c(=O)n(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1 CHEMBL4071161 IC50 5.2 nM
CN1CC(c2ccc(Nc3nc(-c4cc(F)cc(N5CCc6c(sc7c6CC(C)(C)C7)C5=O)c4CO)cn(C)c3=O)cc2)C1 CHEMBL3670126 IC50 5.3 nM
NC(=O)CC1CC=C(c2cc3c(-c4cccc(N5CCOc6cc(C7CC7)cc(F)c6C5=O)c4CO)ccnc3[nH]2)CC1 CHEMBL3929335 IC50 5.3 nM
CC1(C(=O)N2CCCC[C@@H](c3nc(-c4ccc(C(=O)Nc5cc(C(F)(F)F)ccn5)cc4)c4c(N)nccn34)C2)COC1 CHEMBL4099975 IC50 5.3 nM
C=CC(=O)NC1CCc2c(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc3n2C1 CHEMBL4209342 IC50 5.3 nM
COc1cc2cn[nH]c2cc1-c1ccc(F)c2c(N)c(C(N)=O)cnc12 CHEMBL4475004 IC50 5.3 nM
C=C(F)C(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccc(F)cc4F)cc3)c(C(N)=O)c2N)C1 CHEMBL4591391 IC50 5.3 nM
Cc1ccc(Nc2cc(-c3ccnc(-n4ncc5cc(C(C)(C)C)cc(F)c5c4=O)c3CO)cn(C)c2=O)nc1 CHEMBL5187230 IC50 5.3 nM
Cc1cc(F)ccc1Nc1nc2cc(F)c(N(C)C(=O)/C=C/CN(C)C)cc2n2cncc12 CHEMBL1916894 IC50 5.35 nM
CC(C)(C)/C=C(\C#N)C(=O)N1CCC[C@H]1n1nc(-c2ccc(Oc3ccccc3)cc2)c2c(N)ncnc21 CHEMBL4114719 IC50 5.4 nM
C=CC(=O)Nc1cccc(-n2c(=O)c(=O)[nH]c3cnc(Nc4ccc(N5CCN(C)CC5)cc4OC)nc32)c1 CHEMBL4281367 IC50 5.4 nM
C#CC(=O)N1CC(c2cnn3c(C(N)=O)c(-c4ccc(Oc5ccc(OC)cc5)cc4)[nH]c23)C1 CHEMBL4867893 IC50 5.4 nM
Nc1nccn2c([C@H]3CC[C@H]4COC(=O)N4C3)nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3)c12 CHEMBL3953056 IC50 5.5 nM
CS(=O)(=O)N1CC=C(c2cc3c(-c4cccc(N5CCOc6cc(C7CC7)cc(F)c6C5=O)c4CO)ccnc3[nH]2)CC1 CHEMBL3891434 IC50 5.5 nM
C=CC(=O)N1CC[C@H](Nc2ncnc(N)c2-c2ccc(Oc3ccccc3)cc2)C1 CHEMBL4469004 IC50 5.5 nM
Cc1ccccc1Oc1nc2cc(F)c(N(C)C(=O)/C=C/CN(C)C)cc2n2cncc12 CHEMBL1916899 IC50 5.51 nM
Cc1c(NC(=O)c2ccc(C(C)(C)C)cc2)cccc1-c1cn(C)c(=O)c(Nc2ccc(C(=O)NCCNC(=S)Nc3ccc(-c4c5ccc(=O)cc-5oc5cc(O)ccc45)c(C(=O)O)c3)cc2)n1 CHEMBL3400825 IC50 5.6 nM
CC(C)(/C=C(\C#N)C(=O)N1CCC[C@H]1Cn1nc(-c2ccc(Oc3ccccc3)cc2F)c2c(N)ncnc21)N1CC2(COC2)C1 CHEMBL3702846 IC50 5.6 nM
Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)nn2C1CCCN(C(=O)/C=C/CN2CCOCC2)C1 CHEMBL3902180 IC50 5.6 nM
C=CC(=O)Nc1cc(C)ccc1C1CCNc2c(C(N)=O)c(-c3ccc(OCC4CC4)cc3)nn21 CHEMBL3977203 IC50 5.6 nM
C=CC(=O)N1CCC(N2N=C(Nc3ccc(C(=O)N4CCOCC4)cc3)c3c[nH]c4ncnc2c34)CC1 CHEMBL5405186 IC50 5.6 nM
C=CC(=O)Nc1cccc(Nc2nc(Nc3ccc(Oc4ccnc(C(=O)NC)c4)cc3)ncc2[S+](C)[O-])c1 CHEMBL3787055 IC50 5.65 nM
C=CC(=O)Nc1cccc(Nc2nc(Nc3ccc(OCCSC(=S)NCc4ccc(OC)cc4)cc3)ncc2F)c1 CHEMBL4434879 IC50 5.68 nM
NC(=O)c1c(-c2ccc(Oc3ccccc3)cc2)nn2c1NCC[C@H]2C1CCN(C(=O)CCCl)CC1 CHEMBL3979645 IC50 5.7 nM
CC(C)Oc1cc(C(=O)Nc2cc(C(F)(F)F)ccn2)ccc1-c1nc([C@@H]2CC[C@H]3CCC(=O)N3C2)n2ccnc(N)c12 CHEMBL4113636 IC50 5.7 nM
C=CC(=O)N1CCC(n2c(=O)n(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1 CHEMBL5195670 IC50 5.7 nM
C=CC(=O)Nc1cc(Nc2cc(-c3cccc(NC(=O)c4ccc(N(C)C)cc4)c3C)cn(C)c2=O)ccc1C(=O)N1CCOCC1 CHEMBL4085868 IC50 5.8 nM
Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)nn2C1CCN(C2CCN(CC#Cc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)CC2)CC1 CHEMBL5180131 DC50 5.8 nM
CC(C)/C=C(\C#N)C(=O)N1CCC[C@H]1Cn1nc(-c2ccc(Oc3ccccc3)cc2F)c2c(N)ncnc21 CHEMBL3912377 IC50 5.9 nM
Cn1ncc2c1CCC[C@H]2n1nc(-c2ccc(C(=O)Nc3cc(C(F)(F)F)ccn3)cc2)c2c(N)ncnc21 CHEMBL4107331 IC50 5.9 nM
CCn1ncc2c1CCC[C@@H]2n1nc(-c2ccc(C(=O)Nc3cc(C(F)(F)F)ccn3)cc2)c2c(N)ncnc21 CHEMBL3901103 IC50 5.9 nM
CC1(C(=O)N2CC(c3nc(-c4ccc(C(=O)Nc5cc(C(F)(F)F)ccn5)cc4)c4c(N)nccn34)C2)COC1 CHEMBL4086348 IC50 5.9 nM
Cc1c(NC(=O)c2cc3c(s2)CCCC3)cccc1-c1cn(C)c(=O)c(Nc2ccc(C3C(=O)N(C)CCN3C)cc2)n1 CHEMBL4162057 IC50 5.9 nM
C=CC(=O)N1CCC(O)(CNc2ncnc(N)c2-c2ccc(Oc3ccccc3)cc2)CC1 CHEMBL4476695 IC50 5.9 nM
CC(C)/C=C(/C#N)C(=O)N1CCC[C@H]1Cn1nc(-c2ccc(Oc3ccccc3)cc2F)c2c(N)ncnc21 CHEMBL5202266 IC50 5.9 nM
COCCN1CCn2nc(Nc3cc(-c4ccnc(N5CCn6c(cc7c6CC(C)(C)C7)C5=O)c4CO)cn(C)c3=O)cc2C1 CHEMBL5206888 IC50 5.9 nM
C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(NC(=O)C45CC6CC(CC(C6)C4)C5)c4c3OCO4)c3c(N)ncnc32)C1 CHEMBL5420469 IC50 5.94 nM
CC1C=C(c2ccnc(N3CCc4c(sc5c4CCCC5)C3=O)c2CO)C=C(Nc2ccc(N3CCN(C4COC4)CC3)cc2)C1=O CHEMBL4075845 Ki 5.97 nM
Cc1ccc(-c2cn(C)c(=O)c(Nc3ccc([C@@H]4C(=O)N(C)CCN4C)cc3)n2)c(F)c1NC(=O)c1cc2c(s1)CCCC2 CHEMBL3747315 IC50 6.0 nM
Cc1ccc(-c2cn(C)c(=O)c(Nc3ccc([C@H]4C(=O)N(C)CCN4C)cc3)n2)c(F)c1NC(=O)c1cc2c(s1)CCCC2 CHEMBL3747161 IC50 6.0 nM
CN1CCN(C)C(c2ccc(Nc3nc(-c4cccc(NC(=O)c5cc6c(s5)CCCC6)c4Cl)cn(C)c3=O)cc2)C1=O CHEMBL3747554 IC50 6.0 nM
CN1CCN(C)C(c2ccc(Nc3nc(-c4cccc(NC(=O)c5cc6c(s5)CCCC6)c4)cn(C)c3=O)cc2)C1=O CHEMBL3745795 IC50 6.0 nM
Cn1cc(-c2cccc(N3CCc4c(sc5c4CCCC5)C3=O)c2CO)nc(Nc2cnn(CCO)c2)c1=O CHEMBL3670089 IC50 6.0 nM
CN(C)C(C)(C)/C=C(\C#N)C(=O)N1CCC[C@@H]1Cn1nc(-c2ccc(Oc3cccc(F)c3F)cc2F)c2c(N)ncnc21 CHEMBL4115686 IC50 6.0 nM
CC(C)C(=O)N1CCC[C@H]1Cn1nc(-c2ccc(Oc3cccc(F)c3F)cc2F)c2c(N)ncnc21 CHEMBL3974518 IC50 6.0 nM
CC(Cn1nc(-c2ccc(Oc3ccccc3)cc2F)c2c(N)ncnc21)NC(=O)/C(C#N)=C/C(C)(C)N CHEMBL3949568 IC50 6.0 nM
Cc1c(NC(=O)c2ccc(C(C)(O)C(F)(F)F)cc2)cc(F)cc1-c1ncnc2[nH]c(C3=CCN(C(=O)N(C)C)CC3)cc12 CHEMBL3972813 IC50 6.0 nM
CN(C)C(=O)N1CC=C(c2cc3c(-c4ccc(F)c(NC(=O)c5ccc(C6CC6)cc5)c4)ncnc3[nH]2)CC1 CHEMBL3967476 IC50 6.0 nM
CN(C)C(=O)N1CC=C(c2cc3c(-c4ccc(F)c(NC(=O)c5ccc(C(C)(C)CO)cc5)c4)ncnc3[nH]2)CC1 CHEMBL3935663 IC50 6.0 nM
Cc1c(NC(=O)c2ccc(C3CC3)cc2)cc(F)cc1-c1ncnc2[nH]c(C3=CCN(C(=O)N4CCCC4)CC3)cc12 CHEMBL3911315 IC50 6.0 nM
Cc1c(NC(=O)N2CC(OC(C)(C)C)C2)cc(F)cc1-c1ncnc2[nH]c(C3=CCOCC3)cc12 CHEMBL3954000 IC50 6.0 nM
CN1CCN(Cc2ccc(-c3cc4c(-c5cccc(N6CCOc7cc(C8CC8)ccc7C6=O)c5CO)ncnc4[nH]3)cc2)CC1 CHEMBL3921350 IC50 6.0 nM
CCN1CCN(Cc2ccc(-c3cc4c(-c5cccc(N6CCOc7cc(C8CC8)ccc7C6=O)c5CO)ncnc4[nH]3)cc2)CC1 CHEMBL3901371 IC50 6.0 nM
CC1(O)CN(Cc2ccc(-c3cc4c(-c5cccc(N6CCOc7cc(C8CC8)ccc7C6=O)c5CO)ccnc4[nH]3)cc2)C1 CHEMBL3927548 IC50 6.0 nM
CN1CCC(n2cc(-c3cc4c(-c5cccc(N6CCOc7cc(C8CC8)ccc7C6=O)c5CO)ncnc4[nH]3)cn2)CC1 CHEMBL3891185 IC50 6.0 nM
CN(C)C(=O)N1CC=C(c2cc3c(-c4cccc(N5CCOc6cc(C(C)(C)O)ccc6C5=O)c4CO)ccnc3[nH]2)CC1 CHEMBL3980662 IC50 6.0 nM
CN(C)C(=O)N1CC=C(c2cc3c(-c4cccc(-n5ccc6cc(C7CC7)cc(F)c6c5=O)c4CO)ccnc3[nH]2)CC1 CHEMBL4095573 IC50 6.0 nM
C=CC(=O)Nc1cc(Nc2cc(-c3cccc(NC(=O)c4cc5c(s4)CCCC5)c3C)cn(C)c2=O)ccc1C(=O)N1CCOCC1 CHEMBL4096207 Ki 6.0 nM
Cn1cc(-c2cccc(N3CCn4c(cc5c4CCCC5)C3=O)c2CO)cc(Nc2ccncn2)c1=O CHEMBL3670086 IC50 6.0 nM
C/C=C/C(=O)N1CC=C(c2c[nH]c3ncnc(-c4cc(F)cc(NC(=O)c5ccc(C6CC6)cc5)c4C)c23)CC1 CHEMBL4789435 IC50 6.0 nM
Cc1cc(-c2ccnc(N)n2)ccc1CNC(=O)c1cnc(C(C)(C)C)s1 CHEMBL4783488 IC50 6.0 nM
O=C(N[C@@H]1CCCN(c2ncnc3[nH]ncc23)C1)[C@H](Nc1cc(Cl)cc(Cl)c1)C1CC1 CHEMBL5207862 Kd 6.0 nM
CC(C)(/C=C(\C#N)C(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1)CCCOCCOCCOCCOCCOc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O CHEMBL5278934 DC50 6.0 nM
C=CC(=O)N1CCC[C@@H]1Cn1nc(-c2ccc(NC(=O)c3ccc(N(C)C)cc3)c3c2OCO3)c2c(N)ncnc21 CHEMBL5412059 IC50 6.0 nM
C=CC(=O)N1CCc2ccc(-n3c(=O)ccc4cnc5ccc(-c6ccc(N)nc6)cc5c43)cc21 CHEMBL4161149 IC50 6.01 nM
CC(=O)N1CCn2nc(Nc3cc(-c4cccc(N5CCn6c(cc7c6CCCC7)C5=O)c4CO)cn(C)c3=O)cc2C1 CHEMBL3670085 IC50 6.1 nM
Cn1cc(-c2cccc(N3CCn4c(cc5c4CCCC5)C3=O)c2CO)cc(Nc2ccc(N3CCNCC3)cn2)c1=O CHEMBL3670129 IC50 6.1 nM
NC(=O)c1c(-c2ccc(F)c(Cl)c2)nn2c1NCCC2c1ccccc1NC(=O)/C=C/CN1CCCCC1 CHEMBL3946624 IC50 6.1 nM
COc1cc(Nc2nccc(-c3cccc(NC(=O)c4ccc(C(C)(C)C)cc4)c3C)n2)cc(OC)c1OC CHEMBL4211270 IC50 6.1 nM
C=CC(=O)N[C@H]1Cn2c(c(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1=C CHEMBL4214492 IC50 6.1 nM
C=CC(=O)Nc1cccc(Nc2nc(Nc3ccc4c(c3)B(O)OC4)ncc2C)c1 CHEMBL4647822 IC50 6.1 nM
C=CC(=O)N1CCCC[C@H]1c1nc(-c2ccc(C(=O)Nc3cc(I)ccn3)cc2)c(C(N)=O)n1N CHEMBL4873581 IC50 6.1 nM
C#CC(=O)N1CCC(c2cnn3c(C(N)=O)c(-c4ccc(Oc5ccc(C)cc5)cc4)[nH]c23)CC1 CHEMBL4870320 IC50 6.1 nM
N#C/C(=C\C1CC1)C(=O)N1CCC[C@@H]1Cn1nc(-c2ccc(Oc3cccc(F)c3)cc2)c2c(N)ncnc21 CHEMBL4114716 IC50 6.2 nM
C=CC(=O)Nc1cccc(-n2c(=O)n(C)c(=O)c3cnc(Nc4ccccc4)nc32)c1 CHEMBL4128726 IC50 6.2 nM
Cn1cc(-c2nc3c(-c4ccc(CNC(=O)c5ccc(C(C)(C)C)cc5)c(F)c4)ccnc3[nH]2)cn1 CHEMBL4857217 IC50 6.2 nM
CN(C)C/C=C/C(=O)N1CCC(n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)CC1 CHEMBL3917698 IC50 6.3 nM
C=C[C@@H]1OC(=O)N2C[C@H](c3nc(-c4ccc(C(=O)Nc5cc(C(F)(F)F)ccn5)cc4)c4c(N)nccn34)CC[C@@H]12 CHEMBL4109690 IC50 6.3 nM
N#Cc1cc(C(=O)Nc2cc(C(F)(F)F)ccn2)ccc1-c1nc([C@@H]2CC[C@H]3CCC(=O)N3C2)n2ccnc(N)c12 CHEMBL4107939 IC50 6.3 nM
Cn1cc(-c2cncc(N3CCn4c(cc5c4CCCC5)C3=O)c2CO)cc(Nc2ccc(N3CCN(C4COC4)CC3)cn2)c1=O CHEMBL4101904 Ki 6.3 nM
CC1(C(=O)N2CCC[C@@H](c3nc(-c4ccc(C(=O)Nc5cc(C(F)(F)F)ccn5)c(Cl)c4)c4c(N)nccn34)C2)COC1 CHEMBL4758341 IC50 6.3 nM
C#CC(=O)N1CCC(c2cnn3c(C(N)=O)c(-c4ccc(Oc5ccc(F)cc5F)cc4)[nH]c23)CC1 CHEMBL4857353 IC50 6.3 nM
Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)nn2[C@@H]1CCCN(C(=O)CCC(=O)N2CCN(CC#Cc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)CC2)C1 CHEMBL5178047 IC50 6.3 nM
Cn1cc(-c2cc(F)cc(N3CCn4c(cc5c4CC(C)(C)C5)C3=O)c2CO)cc(Nc2ccc(N3CCN(CCF)CC3)cn2)c1=O CHEMBL3639689 IC50 6.35 nM
CCN1CCN(c2ccc(Nc3cc(-c4cc(F)cc(N5CCc6c(sc7c6CC(C)(C)C7)C5=O)c4CO)cn(C)c3=O)nc2)CC1 CHEMBL3670102 IC50 6.4 nM
Cc1c(NC(=O)c2ccc(C(C)(C)C)cc2)cccc1-c1ncnc(Nc2ccc(C(=O)N3CCOCC3)cc2)n1 CHEMBL4215184 IC50 6.4 nM
C#CC(=O)N1CCC(c2cnn3c(C(N)=O)c(-c4ccc(Oc5ccc(OC)cc5)cc4)[nH]c23)CC1 CHEMBL4856592 IC50 6.4 nM
CC(C)N1CC(n2cc(-c3cc4c(-c5cccc(N6CCOc7cc(C8CC8)ccc7C6=O)c5CO)ccnc4[nH]3)cn2)C1 CHEMBL3977803 IC50 6.5 nM
Cc1cc(NC(=O)c2ccc(-c3nc([C@@H]4CC[C@H]5CCC(=O)N5C4)n4ccnc(N)c34)cc2)nn1C CHEMBL4111981 IC50 6.5 nM
C=CC(=O)Nc1cccc(Nc2nc(Nc3ccc(OCC(=O)NCC(=O)OC)cc3)ncc2Cl)c1 CHEMBL4247870 IC50 6.5 nM
C=CC(=O)N1CCC[C@H](Nc2ncnc(N)c2-c2ccc(Oc3ccccc3)cc2)C1 CHEMBL4468148 IC50 6.5 nM
C=CC(=O)Nc1cccc(Nc2nc(Nc3cccc(B(O)O)c3)ncc2C(F)(F)F)c1 CHEMBL4647100 IC50 6.5 nM
C=CC(=O)Nc1cccc(Oc2nc(Nc3ccc4c(c3)COB4O)ncc2C(F)(F)F)c1 CHEMBL4640192 IC50 6.5 nM
C#CC(=O)N[C@@H]1CCN(c2ccc(C(N)=O)c3[nH]c(C)c(C)c23)C1 CHEMBL4634526 IC50 6.5 nM
Cc1cc(F)ccc1Oc1nc2ccc(N(C)C(=O)/C=C/CN(C)C)cc2n2cncc12 CHEMBL1916902 IC50 6.58 nM
C=CC(=O)N1CCc2ccc(-n3c(=O)ccc4cnc5ccc(-c6cnn(C)c6)cc5c43)cc21 CHEMBL4077064 IC50 6.59 nM
C=CC(=O)N1CCc2ccc(N3C(=O)CCc4cnc5ccc(-c6cnn(C)c6)cc5c43)cc21 CHEMBL5289623 IC50 6.59 nM
C=CC(=O)Nc1cccc(Nc2nc(Nc3ccc(OCCOC)cc3)ncc2SC)c1 CHEMBL3787531 IC50 6.6 nM
CC(F)(F)Oc1cc(C(=O)Nc2cc(C(F)(F)F)ccn2)ccc1-c1nc([C@@H]2CC[C@H]3CCC(=O)N3C2)n2c(Cl)cnc(N)c12 CHEMBL4108663 IC50 6.6 nM
COCCC(=O)N1CCSC(c2nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3)c3c(N)nccn23)C1 CHEMBL4079225 IC50 6.6 nM
CN(CCCNC(=O)CNc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O)C(C)(C)/C=C(\C#N)C(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1 CHEMBL5284120 DC50 6.6 nM
C[C@@H]1CC(=O)N2C[C@H](c3nc(-c4ccc(C(=O)Nc5cc(C(F)(F)F)ccn5)cc4)c4c(N)nccn34)CC[C@@H]12 CHEMBL4114924 IC50 6.7 nM
CC(=O)N1CC=C(c2cc3c(-c4cccc(-n5ccc6cc(C7CC7)cc(F)c6c5=O)c4CO)ccnc3[nH]2)CC1 CHEMBL4087347 IC50 6.7 nM
C=CC(=O)N1CCCCC(n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)n[nH]c(=O)c32)C1 CHEMBL4785747 IC50 6.7 nM
Cc1ccc(F)cc1Nc1nc2cc(F)c(N(C)C(=O)/C=C/CN(C)C)cc2n2cncc12 CHEMBL1916893 IC50 6.76 nM
CC1(O)CCN(Cc2ccc(-c3cc4c(-c5cccc(N6CCOc7cc(C8CC8)ccc7C6=O)c5CO)ncnc4[nH]3)cc2)CC1 CHEMBL3907763 IC50 6.8 nM
CN1CCN(C(=O)c2ccc3c(c2)[nH]c2c(C(N)=O)ccc(-c4cccc(F)c4F)c23)CC1 CHEMBL3621512 IC50 6.9 nM
Cc1nc(C(N)=O)c2[nH]c3cc(C(C)(C)O)ccc3c2c1-c1cccc(-n2cnc3ccccc3c2=O)c1C CHEMBL3973901 IC50 6.9 nM
Cc1cc(C(=O)Nc2cc(C(F)(F)F)n(C)n2)ccc1-c1nc([C@@H]2CC[C@H]3CCC(=O)N3C2)n2ccnc(N)c12 CHEMBL4115206 IC50 6.9 nM
Cn1cc(-c2nccc(N3CCn4c(cc5c4CCCC5)C3=O)c2CO)cc(Nc2ccc(N3CCN(C4COC4)CC3)cn2)c1=O CHEMBL4075253 Ki 6.9 nM
C=CC(=O)Nc1cccc(Nc2nc(Nc3ccc(OCCSC(=S)NCc4cccc(F)c4)cc3)ncc2F)c1 CHEMBL4583844 IC50 6.9 nM
CN(C)C(=O)N1CC=C(c2cc3c(-c4cccc(-n5ccc6cc(C7CC7)cc(F)c6c5=O)c4CO)ncnc3[nH]2)CC1 CHEMBL3402584 IC50 7.0 nM
Nc1ncnc2c1c(-c1ccc(F)c(O)c1)nn2C1Cc2ccccc2C1 CHEMBL3942550 IC50 7.0 nM
Cn1nc(Nc2cc(-c3cccc(N4CCc5c(sc6c5CCCC6)C4=O)c3CO)nn(C)c2=O)cc1C(C)(C)O CHEMBL3670090 IC50 7.0 nM
Cc1c(-c2ccc(Oc3ccccc3)cc2)c2c(N)ncnc2n1C[C@H]1CCCN1C(=O)/C(C#N)=C\C(C)(C)N(C)C CHEMBL4109085 IC50 7.0 nM
CC(C)/C=C(\C#N)C(=O)N1CCC[C@@H]1Cn1nc(-c2ccc(Oc3cc(F)ccc3F)cc2)c2c(N)ncnc21 CHEMBL4110649 IC50 7.0 nM
CC(C)/C=C(/C#N)C(=O)N1CCC[C@@H]1Cn1nc(-c2ccc(Oc3cccc(F)c3F)cc2)c2c(N)ncnc21 CHEMBL4108729 IC50 7.0 nM
CCOC(C)(C)/C=C(\C#N)C(=O)C1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3F)c3c(N)ncnc32)C1 CHEMBL4114660 IC50 7.0 nM
N#C/C(=C\C1CC1)C(=O)N1CCC[C@@H]1Cn1cc(-c2ccc(Oc3cccc(F)c3F)cc2)c2c(N)ncnc21 CHEMBL4115694 IC50 7.0 nM
Cc1c(NC(=O)c2ccc(C3CC3)cc2)cc(F)cc1-c1ncnc2[nH]c(C3=CCN(C(=O)CO)CC3)cc12 CHEMBL3894539 IC50 7.0 nM
CC(C)(C)c1ccc(C(=O)Nc2cccc(-c3ncnc4[nH]c(C5=CCOCC5)cc34)c2CO)cc1 CHEMBL3891532 IC50 7.0 nM
Cc1c(NC(=O)N2CC(OC(C)(C)C)C2)cc(F)cc1-c1ncnc2[nH]c(C3=CCN(C(=O)N(C)C)CC3)cc12 CHEMBL3939935 IC50 7.0 nM
Cc1c(-c2ncnc3[nH]c(-c4ccc(CN5CCN(C)CC5)cc4)cc23)cccc1N1CCOc2cc(C3CC3)ccc2C1=O CHEMBL3968928 IC50 7.0 nM
Cc1c(-c2ncnc3[nH]c(-c4ccc(CN5CCNCC5)cc4)cc23)cccc1N1CCc2cc(C3CC3)ccc2C1=O CHEMBL3979851 IC50 7.0 nM
CN1CCN(Cc2ccc(-c3cc4c(-c5cccc(-n6ccc7cc(C8CC8)ccc7c6=O)c5CO)ncnc4[nH]3)cc2)CC1 CHEMBL3962290 IC50 7.0 nM
N#CC1CCN(Cc2ccc(-c3cc4c(-c5cccc(N6CCOc7cc(C8CC8)ccc7C6=O)c5CO)ccnc4[nH]3)cc2)CC1 CHEMBL3931607 IC50 7.0 nM
CN1CCN(Cc2ccc(-c3cc4c(-c5cccc(N6CCOc7cc(C8CC8)ccc7C6=O)c5CO)ccnc4[nH]3)cn2)CC1 CHEMBL3950770 IC50 7.0 nM
CCN1CC(n2cc(-c3cc4c(-c5cccc(N6CCOc7cc(C8CC8)ccc7C6=O)c5CO)ccnc4[nH]3)cn2)C1 CHEMBL3891695 IC50 7.0 nM
O=C1c2ccc(C3CC3)cc2OCCN1c1cccc(-c2ccnc3[nH]c(-c4ccc(CN5CCN(S(=O)(=O)C6CC6)CC5)cn4)cc23)c1CO CHEMBL3904399 IC50 7.0 nM
CC(C)N1CC(n2cnc(-c3cc4c(-c5cccc(N6CCOc7cc(C8CC8)ccc7C6=O)c5CO)ccnc4[nH]3)c2)C1 CHEMBL3957182 IC50 7.0 nM
C=CC(=O)N1CC(C2CCNc3c(C(N)=O)c(-c4ccc(OCCc5ccccc5)cc4)nn32)C1 CHEMBL3890581 IC50 7.0 nM
Cc1c(-c2ccc(C(N)=O)c3[nH]c4cc(C(C)(C)O)ccc4c23)cccc1-n1cnc2ccc(F)cc2c1=O CHEMBL4513599 IC50 7.0 nM
Cc1cc(-c2ccnc(Nc3cnn(C)c3)n2)ccc1CN1CCN(CC2(C)CC2)CC1=O CHEMBL5207196 IC50 7.0 nM
Cc1cc(-c2ccnc(Nc3cnn(C4CN(C)C4)c3)n2)ccc1CN1CCN(CC(C)C)CC1=O CHEMBL5192675 IC50 7.0 nM
Cc1cc(-c2ccnc(Nc3cnn(C4CN(C)C4)c3)n2)ccc1CN1CCN(CC(C)(C)C)CC1=O CHEMBL5208570 IC50 7.0 nM
C=CC(=O)Nc1cccc(N2C(=O)OC(C)c3cnc(Nc4ccc(N5CCN(C)CC5)cc4OC)nc32)c1 CHEMBL5200275 IC50 7.0 nM
CN(c1ncnc2[nH]ncc12)C1COCCN(C(=O)CNc2cc(Cl)cc(Cl)c2)C1 CHEMBL5269279 IC50 7.0 nM
CN1CCN(c2ccc(Nc3cc(-c4cccc(N5CCn6c(cc7c6CCCC7)C5=O)c4CO)nn(C)c3=O)nc2)CC1 CHEMBL3670134 IC50 7.1 nM
CN(C)C/C=C/C(=O)N1CC[C@]2(C1)C[C@H](n1nc(-c3ccc(Oc4ccccc4)cn3)c3c(N)ncnc31)C2 CHEMBL3647530 IC50 7.1 nM
N#C/C(=C\C1CC1)C(=O)N1CCC[C@@H]1Cn1nc(-c2ccc(Oc3cc(F)ccc3F)cc2)c2c(N)ncnc21 CHEMBL4114688 IC50 7.1 nM
CS(=O)(=O)N1CC=C(c2cc3c(-c4cccc(-n5ccc6cc(C7CC7)cc(F)c6c5=O)c4CO)ccnc3[nH]2)CC1 CHEMBL4103325 IC50 7.1 nM
Cn1cc(-c2ccnc(N3CCn4c(cc5c4CC(C)(C)C5)C3=O)c2CO)cc(NC(=O)C2CC2)c1=O CHEMBL4644856 IC50 7.1 nM
Cn1cc(-c2cc(-c3ccc(CN4Cc5cc(C(C)(C)C)sc5C4=O)c(F)c3)cc(=O)[nH]2)cn1 CHEMBL3975094 IC50 7.11 nM
C=CC(=O)Nc1cccc(Nc2nc(Nc3ccc(N(CCOC)CCOC)cc3)ncc2F)c1 CHEMBL4082353 IC50 7.12 nM
C=CC(=O)N1CCc2ccc(-n3c(=O)ccc4cnc5ccc(-c6cnc7ccccc7c6)cc5c43)cc21 CHEMBL4171756 IC50 7.15 nM
Cc1c(NC(=O)c2ccccc2)cccc1-c1ccc(C(N)=O)c2[nH]c3cc(C(=O)N4CCN(C)CC4)ccc3c12 CHEMBL3621519 IC50 7.2 nM
Cn1ncc2c1CCCC2(O)c1nc(-c2ccc(C(=O)Nc3cc(C(F)(F)F)ccn3)cc2)c2c(N)nccn12 CHEMBL3903659 IC50 7.2 nM
CN1C[C@@H]2CC[C@@H](c3nc(-c4ccc(C(=O)Nc5cc(C(F)(F)F)ccn5)cc4)c4c(N)nccn34)CN2C1=O CHEMBL4110412 IC50 7.2 nM
Cn1cc(-c2ccnc(-n3ncc4cc(C(C)(C)C)cc(F)c4c3=O)c2CO)cc(NC(=O)[C@@H]2C[C@H]2F)c1=O CHEMBL4638307 IC50 7.2 nM
CN(C)C/C=C/C(=O)Nc1ccc2nccc(Oc3ccc(C(=O)Nc4ccccn4)cc3)c2c1 CHEMBL4787517 IC50 7.2 nM
C=CC(=O)Nc1ccc2ncnc(Oc3ccc(C(=O)Nc4ccccn4)cc3)c2c1 CHEMBL4798086 EC50 7.2 nM
Cn1cc(-c2ccnc(-n3ncc4cc(C(C)(C)C)cc(F)c4c3=O)c2CO)cc(Nc2ccncn2)c1=O CHEMBL5195945 IC50 7.2 nM
CCOC(C)(C)/C=C(\C#N)C(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4cccc(F)c4F)cc3F)c3c(N)ncnc32)C1 CHEMBL4114793 IC50 7.3 nM
C=CC(=O)Nc1ccccc1C1CCNc2c(C(N)=O)c(-c3ccc(Cl)c(C(F)(F)F)c3)nn21 CHEMBL3931690 IC50 7.3 nM
COC(=O)Nc1nccn2c([C@@H]3CC[C@H]4CCC(=O)N4C3)nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3)c12 CHEMBL4111790 IC50 7.3 nM
O=C(N1CC=C(c2cc3c(-c4cccc(-n5ccc6cc(C7CC7)cc(F)c6c5=O)c4CO)ccnc3[nH]2)CC1)N1CCOCC1 CHEMBL4075160 IC50 7.3 nM
CCC(=O)Nc1cccc(-c2ccc(C(N)=O)c3[nH]c4cc(C(C)(C)O)ccc4c23)c1C CHEMBL4238256 IC50 7.3 nM
CC#CC(=O)N1CCCC[C@H]1c1nc(-c2ccc(C(=O)Nc3cc(C(F)(F)F)ccn3)cc2)c(C(N)=O)n1N CHEMBL4847730 IC50 7.3 nM
C#CC(=O)N1CCC(c2cnn3c(C(N)=O)c(-c4ccc(Oc5ccc(Br)cc5)cc4)[nH]c23)CC1 CHEMBL4867850 IC50 7.3 nM
CC(C)(C)c1cc(F)c2c(=O)n(-c3cccc(-n4cc(C(N)=O)c5cncnc54)c3CO)ncc2c1 CHEMBL3652671 IC50 7.32 nM
C=CC(=O)Nc1cccc(Nc2nc(Nc3ccc(OCCSC(=S)NCc4ccncc4)cc3)ncc2F)c1 CHEMBL4464989 IC50 7.36 nM
C#CCn1cc(-c2cnc(N)c3c(-c4ccc(Oc5ccccc5)cc4)csc23)cn1 CHEMBL3612843 IC50 7.4 nM
C=CC(=O)N[C@@H]1Cn2c(c(-c3ccc(Oc4ccc(C(F)(F)F)cc4)cc3)c3c(N)ncnc32)C1=C CHEMBL4203756 IC50 7.4 nM
C#CC(=O)N1CCC(c2cnn3c(C(N)=O)c(-c4ccc(Oc5ccccc5OC)cc4)[nH]c23)C1 CHEMBL4873984 IC50 7.4 nM
CC(C)/C=C(\C#N)C(=O)N1CCC[C@@H]1Cn1nc(-c2ccc(Oc3c(F)cccc3F)cc2F)c2c(N)ncnc21 CHEMBL4108779 IC50 7.5 nM
C=CC(=O)N[C@H]1CCN(c2ccc(C(N)=O)c(Nc3ccc(C(=O)NC(C)(C)C)cc3)n2)C1 CHEMBL4290066 IC50 7.5 nM
C=CC(=O)N1CC[C@@H]1COc1c(N)ncnc1-c1cc(F)cc(NC(=O)c2ccc(C3CC3)cc2F)c1C CHEMBL4591291 IC50 7.5 nM
C=CC(=O)N1CCC(N2N=C(Nc3ccc(Oc4ccccn4)cc3)c3c[nH]c4ncnc2c34)CC1 CHEMBL5419265 IC50 7.5 nM
Cc1cc(Cl)ccc1Nc1nc2ccc(N(C)C(=O)/C=C/CN(C)C)cc2n2cncc12 CHEMBL1916885 IC50 7.56 nM
Nc1nccn2c([C@@H]3CC[C@@H]4C[C@H](O)C(=O)N4C3)nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3)c12 CHEMBL4108688 IC50 7.6 nM
N#CN1CCC[C@@H](n2nc(-c3ccc(Oc4ncc(Cl)cc4F)cc3)c(C(N)=O)c2N)C1 CHEMBL4462332 IC50 7.6 nM
C#CC(=O)N1CCC(c2cnn3c(C(N)=O)c(-c4ccc(Oc5ccccc5)cc4)[nH]c23)CC1 CHEMBL4871192 IC50 7.6 nM
C=CC(=O)N1CCC(C2CCNc3c(C(N)=O)c(-c4cc(OC)c(Oc5ccccc5)c(OC)c4)nn32)CC1 CHEMBL5266785 IC50 7.6 nM
Cn1cc(-c2cccc(N3CCn4c(cc5c4CCCC5)C3=O)c2CO)cc(Nc2cc3n(n2)CCOC3)c1=O CHEMBL3670087 IC50 7.7 nM
NC(=O)c1c(-c2ccc(Oc3ccccc3)cc2)nn2c3c([nH]c12)CCN(C(=O)CCCl)C3 CHEMBL3934154 IC50 7.7 nM
Cn1cc(-c2ccnc(-n3ncc4c5c(sc4c3=O)CCCC5)c2CO)cc(NC(=O)C2CC2)c1=O CHEMBL4649410 IC50 7.7 nM
CC(C)(C)c1cc(F)c2c(=O)n(-c3cccc(-n4cc(C(N)=O)c5ccc(Br)nc54)c3CO)ncc2c1 CHEMBL3652677 IC50 7.74 nM
Cc1c(NC(=O)c2ccc(C(C)(C)C)cc2)cccc1-c1cn(C)c(=O)c(Nc2ccc(C(=O)NCCOCCOCCNC(=S)Nc3ccc(-c4c5ccc(=O)cc-5oc5cc(O)ccc45)c(C(=O)O)c3)cc2)n1 CHEMBL3402354 IC50 7.8 nM
CC(=O)Cn1cc(-c2cnc(N)c3c(-c4ccc(Oc5ccccc5)cc4)csc23)cn1 CHEMBL3612842 IC50 7.8 nM
Cn1cc(-c2cc(F)cc(N3CCn4c(cc5c4CC(C)(C)C5)C3=O)c2CO)cc(Nc2ccc(N3CCN(C4COC4)CC3)cn2)c1=O CHEMBL3670132 IC50 7.8 nM
C=CC(=O)Nc1ccc2c(c1)-n1nc(-c3ccc(Oc4ccccc4)cc3)c(C(N)=O)c1NC2 CHEMBL3917502 IC50 7.8 nM
Cc1cc(C(=O)Nc2cc(C(F)(F)F)ccn2)c(F)cc1-c1nc([C@@H]2CC[C@H]3CCC(=O)N3C2)n2c(Cl)cnc(N)c12 CHEMBL4110933 IC50 7.8 nM
C/C=C(\C#N)C(=O)N1CCC[C@@H](n2nc(C#CCOc3ccccc3)c3c(N)ncnc32)C1 CHEMBL4582434 IC50 7.8 nM
CS(=O)(=O)N1CC=C(c2cc3c(-c4cccc(-n5ccc6cc(C7CC7)cc(F)c6c5=O)c4CO)ncnc3[nH]2)CC1 CHEMBL3400174 IC50 7.9 nM
C=CC(=O)N1CCC[C@@H](n2nc(C#CCOc3ccccc3)c3c(N)ncnc32)C1 CHEMBL4226237 IC50 7.95 nM
C=CC(=O)N1CCCC(N2NC(c3cc(C(C)(C)O)n(C)n3)c3c(N)ncnc32)C1 CHEMBL5272587 IC50 7.95 nM
Cc1c(NC(=O)c2ccc(C(C)(C)C)cc2)cccc1-c1nc(Nc2ccc(C(=O)N3CCOCC3)cc2)c2nc[nH]c2n1 CHEMBL3263640 IC50 8.0 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1C(=O)Nc1cnc(Nc2ccc(N)cc2)nc1 CHEMBL3290122 IC50 8.0 nM
Cn1cc(-c2cccc(-n3ccc4cc(C5CC5)cc(F)c4c3=O)c2CO)cc(Nc2ccc(N3CCN(C4COC4)CC3)cn2)c1=O CHEMBL3358396 IC50 8.0 nM
Cc1c(NC(=O)c2cc3c(s2)CCCC3)cccc1-c1cn(C)c(=O)c(Nc2ccc(C(=O)N3CCOCC3)cc2)n1 CHEMBL3401277 IC50 8.0 nM
CN1CCN(C)C(c2ccc(Nc3nc(-c4cccc(NC(=O)c5cc6c(s5)CCCC6)c4F)cn(C)c3=O)cc2)C1=O CHEMBL3746128 IC50 8.0 nM
CC(C)(C)/C=C(\C#N)C(=O)N1CCC[C@@H]1Cn1nc(-c2ccc(Oc3ccccc3)cc2F)c2c(N)ncnc21 CHEMBL4114661 IC50 8.0 nM
Cc1c(NC(=O)c2ccc(C(C)(C)O)cc2F)cc(F)cc1-c1ncnc2[nH]c(C3=CCOCC3)cc12 CHEMBL3917989 IC50 8.0 nM
CN(C)C(=O)N1CC=C(c2cc3c(-c4cccc(N5CCc6cc(C(C)(C)C)ccc6C5=O)c4CO)ncnc3[nH]2)CC1 CHEMBL3948173 IC50 8.0 nM
Cc1c(NC(=O)N2CC(OC(C(F)(F)F)C(F)(F)F)C2)cc(F)cc1-c1ncnc2[nH]c(C3=CCN(C(=O)N(C)C)CC3)cc12 CHEMBL3958729 IC50 8.0 nM
Cc1c(NC(=O)c2ccc(C(C)(C)C)cc2)cccc1-c1ncnc2[nH]c(C3=CCC(N(C)C)CC3)cc12 CHEMBL3926464 IC50 8.0 nM
O=C1c2ccc(C3CC3)cc2OCCN1c1cccc(-c2ncnc3[nH]c(-c4ccc(CN5CCOCC5)cc4)cc23)c1CO CHEMBL3935716 IC50 8.0 nM
CCN1CCN(Cc2ccc(-c3cc4c(-c5cccc(N6CCOc7cc(C8CC8)ccc7C6=O)c5CO)ccnc4[nH]3)cn2)CC1 CHEMBL3924327 IC50 8.0 nM
O=C1c2ccc(C3CC3)cc2OCCN1c1cccc(-c2ccnc3[nH]c(-c4ccc(CN5CCN(CC(F)(F)F)CC5)cn4)cc23)c1CO CHEMBL3984930 IC50 8.0 nM
CC1(O)CCN(C(=O)c2ccc(-c3cc4c(-c5cccc(N6CCOc7cc(C8CC8)ccc7C6=O)c5CO)ccnc4[nH]3)nc2)CC1 CHEMBL3918651 IC50 8.0 nM
CC1(O)CCN(C(=O)c2ccc(-c3cc4c(-c5cccc(N6CCOc7cc(C8CC8)cc(F)c7C6=O)c5CO)ccnc4[nH]3)nc2)CC1 CHEMBL3913167 IC50 8.0 nM
CC#CC(=O)N1CCC(C2CCNc3c(C(N)=O)c(-c4ccc(Oc5cccc(Cl)c5)cc4)nn32)CC1 CHEMBL3969461 IC50 8.0 nM
Cn1cc(-c2cccc(N3CCn4c(cc5c4CCCC5)C3=O)c2CO)cc(Nc2ccc(N3CCN(C4COC4)CC3)cn2)c1=O CHEMBL4060453 IC50 8.0 nM
C=CC(=O)N[C@H]1CCN(c2ncc(C(N)=O)c(Nc3ccc(F)cc3)n2)C1 CHEMBL4291033 IC50 8.0 nM
C=CC(=O)Nc1cccc(Oc2nc(Nc3ccc(N4CCN(C(C)=O)CC4)cc3)nc3[nH]cc(-c4cncc(NC)n4)c23)c1 CHEMBL4438914 IC50 8.0 nM
C=CC(=O)Nc1cccc(-c2c(N)ncnc2Nc2ccc(Oc3ccccc3)cc2)c1 CHEMBL4436563 IC50 8.0 nM
O=C1[C@H](Nc2cc(Cl)cc(Cl)c2)CCCN1[C@@H]1CCCN(c2ncnc3[nH]ncc23)C1 CHEMBL5201299 IC50 8.0 nM
CN1CCc2cc(Nc3nc(-c4cc(F)cc(N5CCn6c(cc7c6CCCC7)C5=O)c4CO)cn(C)c3=O)ccc2C1 CHEMBL3670112 IC50 8.1 nM
CC(C)(/C=C(\C#N)C(=O)N1CCC[C@H](n2nc(-c3ccc(Oc4ccccc4)cc3F)c3c(N)ncnc32)C1)CO CHEMBL3954211 IC50 8.1 nM
CN(C)C/C=C/C(=O)N1CC[C@]2(C1)C[C@@H](n1nc(-c3ccc(Oc4ccccc4)cn3)c3c(N)ncnc31)C2 CHEMBL3647529 IC50 8.1 nM
CC(C)(/C=C(\C#N)C(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3F)c3c(N)ncnc32)C1)CO CHEMBL3702829 IC50 8.1 nM
Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)nn2C1CCCC1 CHEMBL2057912 IC50 8.2 nM
Cc1cc(C(=O)Nc2cc(C(F)(F)F)ccn2)c(F)cc1-c1nc([C@@H]2CC[C@H]3CCC(=O)N3C2)n2ccnc(N)c12 CHEMBL4106878 IC50 8.2 nM
C=CC(=O)Nc1cccc(Nc2nc(Nc3ccc4c(c3)COB4O)ncc2OC)c1 CHEMBL4648257 IC50 8.2 nM
C=CC(=O)Nc1cccc(Nc2nc(Nc3ccc(OCCSC(=S)NC)cc3)ncc2F)c1 CHEMBL4473373 IC50 8.21 nM
C=CC(=O)N1CC[C@@H](Nc2ccc(C(N)=O)c3[nH]c(C)c(C)c23)C1 CHEMBL4643248 IC50 8.4 nM
C=CC(=O)N1CCC(CNc2ncnc3[nH]cc(C(=O)NCCOc4ccccc4)c23)CC1 CHEMBL5203573 IC50 8.4 nM
C=CC(=O)N1CCC(C2CCNc3c(C(N)=O)c(-c4cc(OC)c5ccn(C)c5c4)nn32)CC1 CHEMBL5270042 IC50 8.4 nM
C=CC(=O)Nc1cccc(Nc2nc(Nc3ccc(OCCSC(=S)NCc4cnccn4)cc3)ncc2F)c1 CHEMBL4466032 IC50 8.49 nM
C=CC(=O)Nc1cccc(Nc2nc(Nc3ccc4c(c3)B(O)OC4)ncc2F)c1 CHEMBL4647623 IC50 8.5 nM
C=CC(=O)Nc1cccc(Nc2nc(Nc3ccc(OCCSC(=S)NCc4ccc(C#N)cc4)cc3)ncc2F)c1 CHEMBL4590126 IC50 8.58 nM
Cn1cc(-c2cc(F)cc(N3CCc4c(sc5c4CC(C)(C)C5)C3=O)c2CO)cc(Nc2ccc(C3CCN(C4COC4)CC3)cn2)c1=O CHEMBL3670127 IC50 8.7 nM
C=CC(=O)Nc1cccc(Nc2nc(Nc3ccc(OCC(=O)N4CCCC4C(=O)OC)cc3)ncc2Cl)c1 CHEMBL4243975 IC50 8.7 nM
C=CC(=O)Nc1cccc(Nc2nc(Nc3ccc(OCC(=O)NC(C)C(=O)OC)cc3)ncc2Cl)c1 CHEMBL4247474 IC50 8.7 nM
C=CC(=O)NCCOc1c(N)ncnc1-c1cc(F)cc(NC(=O)c2ccc(C3CC3)cc2F)c1C CHEMBL4557061 IC50 8.7 nM
Nc1ncnc2c1c(-c1ccc3c(c1)OCO3)cn2C[C@H]1CCCN1C[C@@H]1CO1 CHEMBL4440181 IC50 8.9 nM
Cc1c(NC(=O)c2ccc(C(C)(C)C)cc2)cccc1-c1c[nH]c(=O)c(Nc2ccc(C(=O)N3CCOCC3)cc2)n1 CHEMBL4447710 IC50 8.9 nM
O=C(CCl)NCCOc1cccc2[nH]c(-c3n[nH]c4cc(C(F)F)ccc34)cc12 CHEMBL4638552 IC50 8.9 nM
Cc1ccc(O)cc1Nc1ccnc(Nc2cccc(C(N)=O)c2)n1 CHEMBL249097 IC50 9.0 nM
Cc1ccc(NC(=O)c2ccc(Cl)c(C(F)(F)F)c2)cc1C(=O)Nc1cnc(Nc2cccc(N)c2)nc1 CHEMBL3290138 IC50 9.0 nM
CN1CC(N2CCN(c3ccc(Nc4cc(-c5cccc(-n6ccc7cc(C8CC8)cc(F)c7c6=O)c5CO)cn(C)c4=O)nc3)CC2)C1 CHEMBL3358397 IC50 9.0 nM
CN1CCN(C)C(c2ccc(Nc3nc(-c4ccc(Cl)c(NC(=O)c5cc6c(s5)CCCC6)c4F)cn(C)c3=O)cc2)C1=O CHEMBL3747268 IC50 9.0 nM
CN1CCN(C)C(c2ccc(Nc3nc(-c4ccc(F)c(NC(=O)c5cc6c(s5)CCCC6)c4)cn(C)c3=O)cc2)C1=O CHEMBL3747551 IC50 9.0 nM
Cc1cc(Nc2cc(-c3ccc(F)c(N4Cc5cc(C(C)(C)C)sc5C4=O)c3)n[nH]c2=O)nn1C CHEMBL3699642 IC50 9.0 nM
Cc1c(NC(=O)c2ccc(C(C)(C)C)cc2)cccc1-c1ncnc2[nH]c(C3=CCC4(CC3)OCCO4)cc12 CHEMBL3963489 IC50 9.0 nM
CN1CCN(Cc2ccc(-c3cc4c(-c5cccc(N6CCOc7cc(C8CC8)ccc7C6=O)c5CO)ccnc4[nH]3)c(F)c2)CC1 CHEMBL3900430 IC50 9.0 nM
Cc1nn(C2CN(C)C2)cc1-c1cc2c(-c3cccc(N4CCOc5cc(C6CC6)ccc5C4=O)c3CO)ccnc2[nH]1 CHEMBL3921994 IC50 9.0 nM
O=C1c2ccc(C3CC3)cc2OCCN1c1cccc(-c2ccnc3[nH]c(-c4ccc(CN5CCS(=O)(=O)CC5)cn4)cc23)c1CO CHEMBL3971512 IC50 9.0 nM
CN1CCC(F)(c2ccc(-c3cc4c(-c5cccc(N6CCOc7cc(C8CC8)ccc7C6=O)c5CO)ccnc4[nH]3)nc2)CC1 CHEMBL3937906 IC50 9.0 nM
CC1(O)CCN(C(=O)c2ccc(-c3cc4c(-c5cccc(N6CCOc7cc(C8CC8)ccc7C6=O)c5CO)ccnc4[nH]3)cc2)CC1 CHEMBL3929529 IC50 9.0 nM
Nc1ncc(C(F)(F)F)n2c([C@@H]3CC[C@H]4CCC(=O)N4C3)nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3Cl)c12 CHEMBL4107483 IC50 9.0 nM
C=CC(=O)N1CCC(CNc2ncnc(N)c2-c2ccc(Oc3cccc(F)c3)cc2)CC1 CHEMBL4548457 IC50 9.0 nM
O=C(Nc1cccc([C@H]2CCCN(c3ncnc4[nH]ccc34)C2)c1)Nc1ccccc1N1CCCC1 CHEMBL4555459 IC50 9.0 nM
Cc1c(NC(=O)c2ccc(F)cn2)cccc1-c1ccc(C(N)=O)c2[nH]c3cc(C(=O)N4CCN(C)CC4)ccc3c12 CHEMBL4466870 IC50 9.0 nM
Cc1cc(-c2cc(N)ncn2)ccc1CNC(=O)c1cnc(C(C)(C)C)s1 CHEMBL4764045 IC50 9.0 nM
CN(C(=O)[C@H](Nc1cc(F)cc(Cl)c1)C1CC1)[C@@H]1CCCN(c2ncnc3[nH]ncc23)C1 CHEMBL5197235 IC50 9.0 nM
O=C(N[C@@H]1CCCN(c2ncnc3[nH]ncc23)C1)[C@H](Nc1cc(F)cc(Cl)c1)C1CC1 CHEMBL5196736 Kd 9.0 nM
Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)nn2[C@@H]1CCCN(C(=O)CCC(=O)NCC#CCN2CCN(CC#Cc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)CC2)C1 CHEMBL5176706 IC50 9.0 nM
Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)nn2[C@@H]1CCCN(C(=O)CCCC(=O)NCC#CCN2CCN(CC#Cc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)CC2)C1 CHEMBL5193859 IC50 9.0 nM
Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)nn2[C@@H]1CCCN(C(=O)CCCCC(=O)NCC#CCN2CCN(CC#Cc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)CC2)C1 CHEMBL5199233 IC50 9.0 nM
Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)nn2[C@@H]1CCCN(C(=O)CCCCCCC(=O)NCC#CCN2CCN(CC#Cc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)CC2)C1 CHEMBL5175307 IC50 9.0 nM
Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)nn2[C@@H]1CCCN(C(=O)/C=C/C(=O)NCC#CCN2CCN(CC#Cc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)CC2)C1 CHEMBL5209299 IC50 9.0 nM
Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)nn2[C@@H]1CCCN(C(=O)/C=C/C(=O)N2CCN(CC#Cc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)CC2)C1 CHEMBL5185546 IC50 9.0 nM
Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)nn2[C@@H]1CCCN(C(=O)C2(C(=O)NCC#CCN3CCN(CC#Cc4ccc5c(c4)CN(C4CCC(=O)NC4=O)C5=O)CC3)CC2)C1 CHEMBL5176012 IC50 9.0 nM
Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)nn2[C@@H]1CCCN(C(=O)C2(C(=O)N3CCN(CC#Cc4ccc5c(c4)CN(C4CCC(=O)NC4=O)C5=O)CC3)CC2)C1 CHEMBL5172741 IC50 9.0 nM
Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)nn2[C@@H]1CCCN(C(=O)[C@H]2CCCC[C@H]2C(=O)NCC#CCN2CCN(CC#Cc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)CC2)C1 CHEMBL5191840 IC50 9.0 nM
Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)nn2[C@@H]1CCCN(C(=O)[C@H]2CCCC[C@H]2C(=O)N2CCN(CC#Cc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)CC2)C1 CHEMBL5169701 IC50 9.0 nM
Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)nn2[C@@H]1CCCN(C(=O)[C@H]2CC[C@H](C(=O)NCC#CCN3CCN(CC#Cc4ccc5c(c4)CN(C4CCC(=O)NC4=O)C5=O)CC3)CC2)C1 CHEMBL5191518 IC50 9.0 nM
Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)nn2[C@@H]1CCCN(C(=O)[C@H]2CC[C@H](C(=O)N3CCN(CC#Cc4ccc5c(c4)CN(C4CCC(=O)NC4=O)C5=O)CC3)CC2)C1 CHEMBL5179158 IC50 9.0 nM
CN(c1ncnc2[nH]ccc12)C1CCCCN(C(=O)CNc2cc(Cl)cc(Cl)c2)C1 CHEMBL5266943 IC50 9.0 nM
C=C(C)C(=O)Nc1cccc(-c2ccc(C(N)=O)c3[nH]c4c(c23)CCC(C(C)(C)O)C4)c1C CHEMBL4244928 IC50 9.1 nM
C=CC(=O)N1CCCC[C@H]1c1nc(-c2ccc(C(=O)Nc3cc(OC)ccn3)cc2)c(C(N)=O)n1N CHEMBL4874550 IC50 9.1 nM
C=CC(=O)Nc1cccc(Nc2nc(Nc3ccc(NS(=O)(=O)c4ccc(OC)cc4)cc3)ncc2Cl)c1 CHEMBL4061898 IC50 9.14 nM
C=CC(=O)N1CCC[C@@H](NC(=O)c2sc3nccc4c3c2NC(=O)N4c2ccc(Oc3ccccc3)cc2F)C1 CHEMBL4854911 Ki 9.2 nM
Cc1c(-c2ccc(C(N)=O)c3[nH]c4c(c23)CCC(C(C)(C)O)C4)cccc1-n1cnc2ccccc2c1=O CHEMBL4237800 IC50 9.3 nM
CN1CCN(C(=O)c2ccc3c(c2)[nH]c2c(C(N)=O)ccc(-c4cccc(NC(=O)c5ccc(F)cc5)c4F)c23)CC1 CHEMBL3622192 IC50 9.4 nM
C#CC(=O)N1CCC(N2N=C(Nc3ccc(Oc4ccccc4)cc3)c3c[nH]c4ncnc2c34)CC1 CHEMBL5431246 IC50 9.4 nM
C=CC(=O)N1CC[C@@H](N2N=C(Nc3ccc(Oc4ccccc4)cc3)c3c[nH]c4ncnc2c34)C1 CHEMBL5404368 IC50 9.48 nM
Nc1ncc(-c2cnn(C3CCCNC3=O)c2)c2scc(-c3ccc(Oc4ccccc4)cc3)c12 CHEMBL3612841 IC50 9.5 nM
C=CC(=O)Nc1ccc(C2CCNc3c(C(N)=O)c(-c4ccc(Oc5ccccc5)cc4)nn32)cc1 CHEMBL3979176 IC50 9.5 nM
Cn1ccc(-c2cc3c(-c4cccc(-n5ccc6cc(C7CC7)cc(F)c6c5=O)c4CO)ccnc3[nH]2)n1 CHEMBL4083867 IC50 9.5 nM
Cc1cc(F)ccc1Nc1nc2cc(Cl)c(N(C)C(=O)/C=C/CN(C)C)cc2n2cncc12 CHEMBL1916898 IC50 9.53 nM
Cc1cc(F)ccc1Oc1nc2cc(F)c(N(C)C(=O)/C=C/CN(C)C)cc2n2cncc12 CHEMBL1916901 IC50 9.53 nM
N#C/C(=C\C1CC1)C(=O)N1CCC[C@@H]1Cn1nc(-c2ccc(Oc3ccc(F)c(F)c3)cc2)c2c(N)ncnc21 CHEMBL4115692 IC50 9.6 nM
Nc1nccn2c([C@@H]3CC[C@@H]4CNCC(=O)N4C3)nc(-c3ccc(C(=O)Nc4cc(C(F)(F)F)ccn4)cc3)c12 CHEMBL4112108 IC50 9.6 nM
CC(C)N1Cc2cc(c(F)cc2F)OCCCNC(=O)c2cnn3ccc1nc23 CHEMBL4449648 IC50 9.67 nM
Cc1c(-c2ncnc3[nH]c(-c4ccc(C(=O)N5CCNCC5)cc4)cc23)cccc1N1CCOc2cc(C3CC3)ccc2C1=O CHEMBL3957615 IC50 9.7 nM
CC(O)c1ccnc(NC(=O)c2ccc(-c3nc([C@@H]4CC[C@H]5CCC(=O)N5C4)n4ccnc(N)c34)cc2)c1 CHEMBL4111750 IC50 9.7 nM
CN(C)S(=O)(=O)N1CC=C(c2cc3c(-c4cccc(-n5ccc6cc(C7CC7)cc(F)c6c5=O)c4CO)ccnc3[nH]2)CC1 CHEMBL4085393 IC50 9.7 nM
CC(C)/C=C(\C#N)C(=O)N1CCC[C@@H](n2nc(C#CCOc3ccccc3)c3c(N)ncnc32)C1 CHEMBL4444564 IC50 9.7 nM
CN1CC(Oc2ccc(Nc3cc(-c4cc(F)cc(N5CCn6c(cc7c6CCCC7)C5=O)c4CO)cn(C)c3=O)nc2)C1 CHEMBL3670121 IC50 9.8 nM
C=CC(=O)N1CC(n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)n[nH]c(=O)c32)C1 CHEMBL4748568 IC50 9.8 nM
C=CC(=O)N1CCC(N2N=C(Nc3ccc(C(=O)Nc4ccccn4)cc3)c3c[nH]c4ncnc2c34)CC1 CHEMBL5399884 IC50 9.8 nM
C=CC(=O)N1CCC[C@@H](n2nc(C#CCOc3cccc(OC)c3)c3c(N)ncnc32)C1 CHEMBL4227934 IC50 9.84 nM
C=CC(=O)NCCn1cc(-c2cnc(N)c3c(-c4ccc(Oc5ccccc5)cc4)csc23)cn1 CHEMBL3612847 IC50 9.9 nM
CCn1nc(Nc2cc(-c3cc(F)cc(N4CCn5c(cc6c5CC(C)(C)C6)C4=O)c3CO)cn(C)c2=O)cc1C CHEMBL3670130 IC50 9.9 nM
C=CC(=O)NC12CCC(Nc3ncnc(N)c3-c3ccc(Oc4ccccc4)cc3)(C1)C2 CHEMBL4441219 IC50 9.9 nM