Cn1ncc2cc(CC(=O)Nc3ccn(Cc4ccc(F)c(F)c4)n3)ccc21 CHEMBL4203847 IC50 0.76 nM
CN(C)c1ccc(CC(=O)Nc2ccn(Cc3ccc(F)c(F)c3)n2)cc1 CHEMBL4205005 IC50 0.89 nM
COc1c(F)cc(Cn2ccc(NC(=O)Cc3ccc(N(C)C)cc3)n2)cc1F CHEMBL4216687 IC50 0.92 nM
CN(C)c1ccc(CC(=O)Nc2ccn(Cc3ccc(OC(F)(F)F)cc3)n2)cc1 CHEMBL4204507 IC50 1.0 nM
CN(C)c1ccc(CC(=O)Nc2ccn(Cc3ccc(Cl)cc3)n2)cc1 CHEMBL4204077 IC50 1.1 nM
C[C@@H](NC(=O)Cc1ccc(C2CC2)cc1)c1ccc(OCC(F)(F)F)cn1 CHEMBL1684954 Ki 1.2 nM
CC1(c2ccc(CC(=O)Nc3ccn(Cc4ccc(F)c(F)c4)n3)cc2)COC1 CHEMBL4215974 IC50 1.2 nM
CC(C)c1ccc(CC(=O)Nc2ccn(CC3CCC(F)(F)CO3)n2)cc1 CHEMBL4205399 IC50 1.2 nM
O=C(Cc1ccc(C2(F)COC2)cc1)Nc1ccn(Cc2ccc(F)c(F)c2)n1 CHEMBL4208626 IC50 1.3 nM
CC(C)c1ccc(CC(=O)N[C@H](C)c2ccc(OCC(F)(F)F)cn2)cc1 CHEMBL1684950 IC50 1.5 nM
Cn1ncc2cc(CC(=O)Nc3cnn(Cc4ccc(F)c(F)c4)n3)ccc21 CHEMBL4209481 IC50 1.5 nM
CN(C)c1ccc(CC(=O)Nc2ccn(Cc3ccc(OC(F)F)cc3)n2)cc1 CHEMBL4209376 IC50 1.6 nM
Cc1cc(CC(=O)Nc2ccn(Cc3ccc(C#N)cn3)n2)ccc1OCC(F)(F)F CHEMBL4208907 IC50 1.7 nM
Cc1ccc(Cn2ccc(NC(=O)Cc3ccc(N(C)C)cc3)n2)cc1 CHEMBL4213335 IC50 1.8 nM
CC1(C)OCC(c2ccc(CC(=O)Nc3ccn(Cc4ccc(F)c(F)c4)n3)cc2)O1 CHEMBL4203748 IC50 1.8 nM
CN(C)c1ccc(CC(=O)Nc2ccn(Cc3ccc(C#N)c(F)c3)n2)cc1 CHEMBL4218161 IC50 1.8 nM
CC(C)c1ccc(CC(=O)Nc2ccn(Cc3ccc(F)c(F)c3)n2)cc1 CHEMBL4207031 IC50 1.8 nM
O=C(Cc1ccc(C2CC(F)(F)C2)cc1)Nc1ccn(Cc2ccc(F)c(F)c2)n1 CHEMBL4206509 IC50 1.8 nM
CN1C(=O)C(C)(C)c2cc(CC(=O)Nc3ccn(Cc4ccc(F)c(F)c4)n3)ccc21 CHEMBL4203101 IC50 1.8 nM
O=C(Cc1ccc2cc[nH]c2c1)Nc1ccn(Cc2ccc(F)c(F)c2)n1 CHEMBL4212039 IC50 1.9 nM
C[C@@H]1CN(Cc2ccccc2)c2ccccc2[C@H](C)N1C(=O)NCc1ccccc1 CHEMBL3913893 IC50 2.0 nM
CN(C)c1ccc(CC(=O)Nc2ccn(Cc3ccc(F)cc3)n2)cc1 CHEMBL4208950 IC50 2.0 nM
Cc1cc(CC(=O)Nc2ccn(Cc3ccc(C#N)cn3)n2)ccc1OC(F)(F)F CHEMBL4212176 IC50 2.0 nM
O=C(Cc1ccc2[nH]ccc2c1)Nc1ccn(Cc2ccc(F)c(F)c2)n1 CHEMBL4207159 IC50 2.1 nM
O=C(Cc1ccc(N2CCC(F)(F)C2)nc1)Nc1ccn(Cc2ccc(F)c(F)c2)n1 CHEMBL4214862 IC50 2.3 nM
CC(C)(C)c1ccc(CC(=O)Nc2ccn(Cc3ccc(C#N)cn3)n2)cc1 CHEMBL4218608 IC50 2.6 nM
Cc1cccc(Cn2ccc(NC(=O)Cc3ccc(N(C)C)cc3)n2)c1 CHEMBL4208413 IC50 2.8 nM
Cn1c(=O)oc2cc(CC(=O)Nc3ccn(Cc4ccc(F)c(F)c4)n3)ccc21 CHEMBL4207979 IC50 2.8 nM
CN(C)c1ccc(CC(=O)Nc2ccn(Cc3ccccc3)n2)cc1 CHEMBL4217227 IC50 2.9 nM
CCc1cc(CC(=O)Nc2ccn(Cc3ccc(C#N)cn3)n2)ccc1OCC(F)(F)F CHEMBL4207291 IC50 2.9 nM
Cn1ccc2cc(CC(=O)Nc3ccn(Cc4ccc(F)c(F)c4)n3)cnc21 CHEMBL4204295 IC50 3.3 nM
COc1ccc(Cn2ccc(NC(=O)Cc3ccc(N(C)C)cc3)n2)cc1 CHEMBL4216279 IC50 3.4 nM
CC(C)c1ccc(CC(=O)Nc2ccn(CCOCC(F)(F)F)n2)cc1 CHEMBL4210292 IC50 3.4 nM
CN(C)c1ccc(CC(=O)Nc2ccn(Cc3ccc(C#N)cc3)n2)cc1 CHEMBL4204611 IC50 3.5 nM
O=C(Cc1ccc(OC2COC2)cc1)Nc1ccn(Cc2ccc(F)c(F)c2)n1 CHEMBL4204873 IC50 3.6 nM
C[C@@H]1CN(Cc2cccc(F)c2F)c2ccccc2[C@H](C)N1C(=O)NCc1ccccc1 CHEMBL3906199 IC50 4.0 nM
[2H]C([2H])(c1ccccc1)N1C[C@@H](C)N(C(=O)Nc2cccnc2)[C@@H](C)c2ccccc21 CHEMBL3921765 IC50 4.0 nM
C[C@@H]1CN(Cc2ccccc2)c2cc(F)ccc2[C@H](C)N1C(=O)Nc1cccnc1 CHEMBL3936835 IC50 4.0 nM
C[C@@H]1CN(Cc2ccccc2)c2nc(F)ccc2[C@H](C)N1C(=O)NCc1ccccc1 CHEMBL3906825 IC50 4.0 nM
CN(C)c1ccc(CC(=O)Nc2ccn(Cc3ccc(F)c(F)c3)n2)cn1 CHEMBL4211393 IC50 4.0 nM
Cc1cc(CC(=O)Nc2ccn(Cc3ccc(C#N)cn3)n2)ccc1OCCC(F)(F)F CHEMBL4204573 IC50 4.1 nM
CC(C(=O)Nc1ccn(Cc2ccc(F)cc2)n1)c1ccc(N(C)C)cc1 CHEMBL4209751 IC50 4.7 nM
COc1ccc([C@@H](C)NC(=O)Cc2ccc(C(C)(C)C)cc2)nc1 CHEMBL1684932 Ki 5.0 nM
C[C@@H]1CN(Cc2ccccc2F)c2ccccc2[C@H](C)N1C(=O)Nc1cccnc1 CHEMBL3924174 IC50 5.0 nM
C[C@@H]1CN(Cc2cccc(F)c2)c2ccccc2[C@H](C)N1C(=O)Nc1cccnc1 CHEMBL3896161 IC50 5.0 nM
O=C(NCc1ccc(N2CCCC2)nc1)c1coc(Cc2ccc(OC(F)(F)F)cc2)n1 CHEMBL4205975 IC50 5.2 nM
O=C(Cc1ccc(N2CC[C@H](F)C2)nc1)Nc1ccn(Cc2ccc(F)c(F)c2)n1 CHEMBL4209946 IC50 5.4 nM
CCCC1(c2ccccc2)c2c(ccc(F)c2F)N(Cc2cc[n+]([O-])cc2)C(=O)N1CC(F)(F)F CHEMBL1222521 Activity 6.0 nM
COc1ccc(CNC(=O)N2[C@H](C)CN(Cc3ccccc3)c3ccccc3[C@@H]2C)cc1 CHEMBL3934860 IC50 6.0 nM
C[C@@H]1CN(Cc2ccccc2)c2ccccc2[C@H](C)N1C(=O)Cc1cncs1 CHEMBL3950196 IC50 6.0 nM
C[C@@H]1CN(Cc2ccc(F)c(F)c2)c2ccccc2[C@H](C)N1C(=O)Nc1cccnc1 CHEMBL3968363 IC50 6.0 nM
C[C@@H]1CN(Cc2ccc(C(F)(F)F)o2)c2ccccc2[C@H](C)N1C(=O)NCc1ccccc1 CHEMBL3969822 IC50 6.0 nM
C[C@@H]1CN(Cc2cnc(C(F)(F)F)s2)c2ccccc2[C@H](C)N1C(=O)NCc1ccccc1 CHEMBL3918060 IC50 6.0 nM
O=C(Cc1ccc(OC2CC(F)(F)C2)cc1)Nc1ccn(Cc2ccc(F)c(F)c2)n1 CHEMBL4211105 IC50 6.1 nM
COc1ccc(CC(=O)Nc2ccn(Cc3ccccc3)n2)cc1C CHEMBL4209075 IC50 6.5 nM
CC1(COc2ccc(CC(=O)Nc3ccn(Cc4ccc(F)c(F)c4)n3)cc2)COC1 CHEMBL4206219 IC50 6.6 nM
C[C@@H]1CN(Cc2ccccc2)c2ccccc2[C@H](C)N1C(=O)CN1CCOCC1 CHEMBL3984489 IC50 7.0 nM
C[C@@H]1CN(Cc2ccc(F)cc2)c2ccccc2[C@H](C)N1C(=O)Nc1cccnc1 CHEMBL3897240 IC50 7.0 nM
CC(C)c1ccc(CC(=O)Nc2nc(Cc3ccc(F)c(F)c3)cs2)cc1 CHEMBL4216756 IC50 7.1 nM
N#Cc1ccc(Cn2ccc(NC(=O)Cc3ccc(C4(C(F)(F)F)CC4)cc3)n2)nc1 CHEMBL4217292 IC50 7.5 nM
CC(C)c1ccc(CC(=O)Nc2ccn(Cc3ccccc3)n2)cc1 CHEMBL4218617 IC50 7.6 nM
CC(C)(C)c1ccc(CC(=O)Nc2ncn(Cc3ccc(F)c(F)c3)n2)cc1 CHEMBL4205754 IC50 7.9 nM
C[C@@H]1CN(Cc2ccccc2)c2ccccc2[C@H](C)N1C(=O)C1CCOCC1 CHEMBL3979902 IC50 8.0 nM
C[C@@H]1CN(Cc2ccccc2)c2ccc(F)cc2[C@H](C)N1C(=O)Nc1cccnc1 CHEMBL3914936 IC50 8.0 nM
C[C@@H]1CN(Cc2ccccc2)c2cc(F)cc(F)c2[C@H](C)N1C(=O)Nc1cccnc1 CHEMBL3945715 IC50 8.0 nM
C[C@@H]1CN(Cc2ccccc2)c2ncccc2[C@H](C)N1C(=O)NCc1ccccc1 CHEMBL3943761 IC50 8.0 nM
CC(C)c1ccc(CC(=O)NCc2ccn(Cc3ccc(F)c(F)c3)n2)cc1 CHEMBL4209235 IC50 8.0 nM
N#CC1(c2ccc(F)cc2)c2c(ccc(F)c2F)NC(=O)N1CC(F)(F)F CHEMBL1223532 Activity 9.0 nM
C[C@@H]1CN(Cc2ccccc2)c2ccccc2[C@H](C)N1C(=O)N1CCOCC1 CHEMBL3977114 IC50 9.0 nM
C[C@@H]1CN(Cc2ccc(C(F)(F)F)o2)c2ccccc2[C@H](C)N1C(=O)Nc1cccnc1 CHEMBL3931239 IC50 9.0 nM
C[C@@H]1CN(Cc2ccccc2)c2cncc(F)c2[C@H](C)N1C(=O)NCc1ccccc1 CHEMBL3933865 IC50 9.0 nM
Cn1cnc2ccc(CC(=O)Nc3ccn(Cc4ccc(F)c(F)c4)n3)cc21 CHEMBL4211522 IC50 9.0 nM
CN(C)c1ccc(CNC(=O)c2nc(Cc3ccc(F)c(F)c3)cs2)cc1 CHEMBL4210341 IC50 9.7 nM
CC(C)c1ccc(CC(=O)NC(C)c2ccn(Cc3ccc(F)c(F)c3)n2)cc1 CHEMBL4206470 IC50 9.8 nM
CCCOc1ccc([C@@H](C)NC(=O)Cc2ccc(C(C)C)cc2)nc1 CHEMBL1684949 IP 10.0 nM
C[C@@H]1CN(Cc2ccccc2)c2ccccc2[C@H](C)N1C(=O)CCc1cccnc1 CHEMBL3941448 IC50 10.0 nM
C[C@@H]1CN(Cc2cccnc2F)c2ccccc2[C@H](C)N1C(=O)NCc1ccccc1 CHEMBL3978193 IC50 10.0 nM
COc1ccc(CN2C[C@@H](C)N(C(=O)NCc3ccccc3)[C@@H](C)c3ccccc32)cn1 CHEMBL3940280 IC50 10.0 nM
C[C@@H]1CN(Cc2ccccc2)c2cccc(F)c2[C@H](C)N1C(=O)Nc1cccnc1 CHEMBL3984761 IC50 10.0 nM
C[C@@H]1CN(Cc2ccc(C(F)(F)F)o2)c2cnccc2[C@H](C)N1C(=O)NCc1ccccc1 CHEMBL3926060 IC50 10.0 nM
CN(C)c1ccc(Cc2nc3cn(Cc4ccc(F)cc4)nc3[nH]2)cc1 CHEMBL4205371 IC50 10.0 nM
O=C(NCc1ccc(N2CCC(F)(F)C2)nc1)c1ccn(Cc2ccc(F)c(F)c2)n1 CHEMBL4218220 IC50 10.0 nM
Cn1ncc2cc(CC(=O)Nc3nn(Cc4ccc(F)c(F)c4)cc3C#N)ccc21 CHEMBL4205068 IC50 10.0 nM
O=C(Cc1ccc(C2CC2)nc1)Nc1ccn(Cc2ccc(F)c(F)c2)n1 CHEMBL4202684 IC50 10.0 nM
CCCOc1ccc([C@@H](C)NC(=O)Cc2ccc(C3CC3)cc2)nc1 CHEMBL1684953 IP 11.0 nM
COc1ccc(CNC(=O)N2[C@H](C)CN(Cc3ccc(C(F)(F)F)o3)c3cnccc3[C@@H]2C)cc1 CHEMBL3938021 IC50 11.0 nM
C[C@@H]1CN(Cc2ccccc2)c2cnccc2[C@H](C)N1C(=O)NCc1ccccc1 CHEMBL3895005 IC50 11.0 nM
O=C(Cc1ccc(OCC(F)(F)F)nc1)Nc1ccn(Cc2ccc(F)c(F)c2)n1 CHEMBL4214341 IC50 11.0 nM
CCC1(c2ccccc2)c2c(ccc(F)c2F)N(Cc2cc[n+]([O-])cc2)C(=O)N1CC(F)(F)F CHEMBL1222520 Activity 12.0 nM
C[C@@H]1CN(Cc2ccccc2)c2ccccc2[C@H](C)N1C(=O)NC1COC1 CHEMBL3898772 IC50 12.0 nM
CC(C)CCN1C[C@@H](C)N(C(=O)Nc2cccnc2)[C@@H](C)c2ccccc21 CHEMBL3985310 IC50 12.0 nM
C[C@@H]1CN(CCOC(C)(C)C)c2ccccc2[C@H](C)N1C(=O)NCc1ccccc1 CHEMBL3939715 IC50 12.0 nM
COc1ccc(CNC(=O)N2[C@H](C)CN(Cc3ccccc3)c3cnccc3[C@@H]2C)cc1 CHEMBL3956823 IC50 12.0 nM
CC(C)CCN1C[C@@H](C)N(C(=O)CCc2cccnc2)[C@@H](C)c2ccccc21 CHEMBL3916048 IC50 13.0 nM
C[C@@H]1CN(Cc2cnc(C(F)(F)F)s2)c2ccccc2[C@H](C)N1C(=O)CCc1cccnc1 CHEMBL3902886 IC50 13.0 nM
C[C@@H]1CN(Cc2ccccc2)c2cccc(F)c2[C@H](C)N1C(=O)NC1COC1 CHEMBL3926201 IC50 13.0 nM
C[C@@H]1CN(Cc2cccc(F)c2F)c2cnccc2[C@H](C)N1C(=O)NCc1ccccc1 CHEMBL3942836 IC50 13.0 nM
O=C1Nc2ccc(F)c(F)c2C(CC(F)F)(c2ccc(F)cc2)N1CC(F)(F)F CHEMBL1222450 Activity 14.0 nM
N#Cc1ccc([C@@]2(C3CC3)c3cc(Cl)ccc3NC(=O)N2CC(F)(F)F)cc1 CHEMBL1222523 Activity 14.0 nM
C[C@@H]1CN(Cc2ccccc2)c2ccccc2[C@H](C)N1C(=O)Nc1cccnc1 CHEMBL3889862 IC50 14.0 nM
C[C@@H]1CN(Cc2cccc(C(F)(F)F)n2)c2ccccc2[C@H](C)N1C(=O)NCc1ccccc1 CHEMBL3949063 IC50 14.0 nM
C[C@@H]1CN(CC2CCCC2)c2ccccc2[C@H](C)N1C(=O)Nc1cccnc1 CHEMBL3915547 IC50 14.0 nM
Cn1ncc2cc(CNC(=O)c3cnn(Cc4ccc(F)c(F)c4)n3)ccc21 CHEMBL4217691 IC50 14.0 nM
C[C@@H]1CN(Cc2ccccc2)c2ncc(F)cc2[C@H](C)N1C(=O)NCc1ccccc1 CHEMBL3925915 IC50 15.0 nM
[2H]C([2H])(c1ccccc1)N1C[C@@H](C)N(C(=O)NCc2ccccc2)[C@@H](C)c2ccncc21 CHEMBL3980491 IC50 15.0 nM
O=C(Cc1ccc(OC(F)(F)F)cc1)Nc1ccn(Cc2ccccc2)n1 CHEMBL4215146 IC50 15.0 nM
CN(C)c1ccc(CNC(=O)c2csc(Cc3ccc(F)c(F)c3)n2)cc1 CHEMBL4205450 IC50 15.0 nM
CCC1(c2ccc(F)cc2)c2c(ccc(F)c2F)NC(=O)N1CC(F)(F)F CHEMBL1223530 Activity 16.0 nM
CC(C)c1ccc(CC(=O)N[C@H](C)c2ccc(OCc3ccccc3)cn2)cc1 CHEMBL1684948 IP 16.0 nM
O=C1Nc2ccc(F)c(F)c2C(CCF)(c2ccc(F)cc2)N1CC(F)(F)F CHEMBL1223534 Activity 17.0 nM
C[C@@H]1CN(Cc2ccccc2)c2c(F)cccc2[C@H](C)N1C(=O)Nc1cccnc1 CHEMBL3908881 IC50 17.0 nM
C[C@@H]1CN(Cc2ccccc2)c2cccc(F)c2[C@H](C)N1C(=O)CCc1cccnc1 CHEMBL3912958 IC50 17.0 nM
O=C(NCc1ccc(C2(F)COC2)cc1)c1ccn(Cc2ccc(F)c(F)c2)n1 CHEMBL4213283 IC50 17.0 nM
Cc1ccc(CC(=O)Nc2ccn(Cc3ccccc3)n2)cc1 CHEMBL4212175 IC50 18.0 nM
CCC1(c2ccccc2)c2c(ccc(F)c2F)NC(=O)N1CC(F)(F)F CHEMBL1223461 Activity 20.0 nM
C[C@@H]1CN(Cc2cnc(C(F)(F)F)s2)c2cccc(F)c2[C@H](C)N1C(=O)CCc1cccnc1 CHEMBL3930876 IC50 20.0 nM
C[C@@H](NC(=O)Cc1ccc(C2CC2)cc1)c1ccc(OCc2ccccc2)cn1 CHEMBL1684952 IP 21.0 nM
CC(C)(C)NC(=O)CN1CCC(CNC(=O)c2cc(Cl)cc(Cl)c2)CC1 CHEMBL493467 IC50 22.0 nM
C[C@@H]1CN(Cc2ccccc2)c2nc(Cl)ccc2[C@H](C)N1C(=O)NCc1ccccc1 CHEMBL3915799 IC50 22.0 nM
O=C(NCc1ccc2[nH]ccc2c1)c1ccn(Cc2ccc(F)c(F)c2)n1 CHEMBL4208810 IC50 22.0 nM
C[C@@H]1CN(CCOC(C)(C)C)c2ccccc2[C@H](C)N1C(=O)Nc1cccnc1 CHEMBL3977684 IC50 23.0 nM
O=C(Cc1ccc(Cl)cc1)Nc1ccn(Cc2ccccc2)n1 CHEMBL4206874 IC50 24.0 nM
CCC1(c2ccc(F)cc2)c2cc(F)ccc2NC(=O)N1CC(F)(F)F CHEMBL1223464 Activity 25.0 nM
CCCC1(c2ccc(F)cc2)c2cc(Cl)ccc2NC(=O)N1CC(F)(F)F CHEMBL1223172 Activity 25.0 nM
C[C@@H]1CN(Cc2ccccc2)c2cnccc2[C@H](C)N1C(=O)CCc1ccc(F)cc1 CHEMBL3951580 IC50 25.0 nM
COc1ccc(CNC(=O)N2[C@H](C)CN(CCC(C)C)c3cnccc3[C@@H]2C)cc1 CHEMBL3910085 IC50 25.0 nM
CCOc1ccc(CC(=O)Nc2ccn(Cc3ccccc3)n2)cc1 CHEMBL4203473 IC50 25.0 nM
C[C@@H]1CN(Cc2ccccc2)c2ccccc2CN1C(=O)NCc1ccccc1 CHEMBL3959377 IC50 26.0 nM
CC(C)(C)CCN1CCC(CNC(=O)Cc2ccc(C(C)(C)C)cc2)CC1 CHEMBL523508 IC50 27.0 nM
C[C@@H](NC(=O)Cc1ccc(C(C)(C)C)cc1)c1ccc(Cl)cn1 CHEMBL1684931 IP 30.0 nM
C[C@@H]1CN(Cc2ccccc2F)c2cnccc2[C@H](C)N1C(=O)NCc1ccccc1 CHEMBL3972450 IC50 31.0 nM
CC(C)(C)CCN1CC[C@H](CNC(=O)c2cc(Cl)cc(Cl)c2)[C@H](F)C1 CHEMBL493677 IC50 32.0 nM
COc1ccc(CC(=O)Nc2ccn(Cc3ccccc3)n2)cc1 CHEMBL4210726 IC50 32.0 nM
C[C@@H]1CN(Cc2cnc(C(F)(F)F)s2)c2ccccc2[C@H](C)N1C(=O)Nc1cccnc1 CHEMBL3972616 IC50 33.0 nM
Cc1ccc2c(n1)N(Cc1ccccc1)C[C@@H](C)N(C(=O)NCc1ccccc1)[C@H]2C CHEMBL3897825 IC50 33.0 nM
CCC(C)C(C)CN1CCC(CNC(=O)c2cc(Cl)cc(Cl)c2)CC1 CHEMBL522697 IC50 38.0 nM
O=C1N(Cc2cc[n+]([O-])cc2)c2ccc(F)c(F)c2C(CCF)(c2ccccc2)N1CC(F)(F)F CHEMBL1222522 Activity 38.0 nM
CCCC1(c2ccccc2)c2cc(F)ccc2NC(=O)N1CC(F)(F)F CHEMBL1223462 Activity 38.0 nM
Cc1ccccc1Cn1ccc(NC(=O)Cc2ccc(N(C)C)cc2)n1 CHEMBL4217744 IC50 40.0 nM
CC(C)c1ccc(CNC(=O)c2ccn(Cc3ccc(F)c(F)c3)n2)cc1 CHEMBL4203931 IC50 40.0 nM
CC(C)(C)CCN1CCC(CNC(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1 CHEMBL493678 IC50 41.0 nM
CC(C)(C)OCCN1CCC(CNC(=O)c2cc(Cl)cc(Cl)c2)CC1 CHEMBL522843 IC50 42.0 nM
O=C1Nc2ccc(Cl)cc2C(CCF)(c2ccc(F)cc2)N1CC(F)(F)F CHEMBL1223324 Activity 42.0 nM
CC(C)(C)CCN1CCC(CNC(=O)c2ccc(Cl)c(Cl)c2)CC1 CHEMBL493679 IC50 45.0 nM
COc1ccc([C@@H](C)NC(=O)Cc2ccc(C(C)C)cc2)nc1 CHEMBL1684945 IP 45.0 nM
C[C@@H]1CN(Cc2ccccc2)c2ncc(Cl)cc2[C@H](C)N1C(=O)NCc1ccccc1 CHEMBL3934795 IC50 46.0 nM
CCC1(c2ccccc2)c2cc(F)ccc2NC(=O)N1CC(F)(F)F CHEMBL1223394 Activity 50.0 nM
CC(C)CCN1C[C@@H](C)N(C(=O)CCc2cccnc2)[C@@H](C)c2c(F)cccc21 CHEMBL3921940 IC50 52.0 nM
CCC1(c2ccc(F)cc2)c2c(ccc(F)c2F)N(CCOC)C(=O)N1CC(F)(F)F CHEMBL1222451 Activity 53.0 nM
C[C@@H]1CN(Cc2ccccc2)c2cnc(Cl)cc2[C@H](C)N1C(=O)NCc1ccccc1 CHEMBL3986638 IC50 55.0 nM
O=C1Nc2ccc(Cl)cc2C(CC(F)F)(c2ccc(F)cc2)N1CC(F)(F)F CHEMBL1223252 Activity 60.0 nM
CC(C)(C)CCN1CCC(CNC(=O)c2cc(Cl)cc(Cl)c2)CC1 CHEMBL488468 IC50 61.0 nM
CC[C@]1(c2ccc(F)cc2)c2cc(Cl)ccc2NC(=O)N1CC(F)(F)F CHEMBL1223091 Activity 61.0 nM
CCCC1(c2cccc(-c3nccs3)c2)c2cc(Cl)ccc2NC(=O)N1CC(F)(F)F CHEMBL1223322 Activity 62.0 nM
CC(C)(C)CCN1CCC(F)(CNC(=O)c2cc(Cl)cc(Cl)c2)CC1 CHEMBL486247 Activity 64.0 nM
O=C(Cc1cccc(Cl)c1)Nc1ccn(Cc2ccccc2)n1 CHEMBL4211644 IC50 64.0 nM
Cc1cccc(CC(=O)Nc2ccn(Cc3ccccc3)n2)c1 CHEMBL4207290 IC50 67.0 nM
COc1ccc([C@@H](C)NC(=O)Cc2ccc(C3CC3)cc2)nc1 CHEMBL1684946 IP 70.0 nM
CCC1(c2ccccc2)c2cc(Cl)ccc2NC(=O)N1CC(F)(F)F CHEMBL1223095 Activity 71.0 nM
CCCC1(c2cccc(Oc3ccccn3)c2)c2cc(Cl)ccc2NC(=O)N1CC(F)(F)F CHEMBL1223250 Activity 73.0 nM
COc1cc2c(cc1F)N(Cc1ccccc1)C[C@@H](C)N(C(=O)Nc1cccnc1)[C@H]2C CHEMBL3899835 IC50 73.0 nM
Cc1ccc2c(c1)N(Cc1ccccc1)C[C@@H](C)N(C(=O)Nc1cccnc1)[C@H]2C CHEMBL3903942 IC50 74.0 nM
CC1(C)C[C@@H](CN2CCC(F)(CNC(=O)c3cc(Cl)cc(Cl)c3)CC2)CCO1 CHEMBL488817 IC50 82.0 nM
CC(C)(C)NC(=O)CN1CCC(CNC(=O)c2cc(F)cc(Cl)c2)CC1 CHEMBL3934636 IC50 86.0 nM
C=CCC1(c2ccccc2)c2cc(Cl)ccc2NC(=O)N1CC(F)(F)F CHEMBL1223094 Activity 87.0 nM
C[C@@H]1CN(Cc2ccccc2)c2cccnc2[C@H](C)N1C(=O)NCc1ccccc1 CHEMBL3963167 IC50 91.0 nM
O=C(NCC1CCN(Cc2cccc(C(F)(F)F)c2)CC1)c1cc(Cl)cc(Cl)c1 CHEMBL523525 IC50 93.0 nM
CC1(C)C[C@H](CN2CCC(F)(CNC(=O)c3cc(Cl)cc(Cl)c3)CC2)CCO1 CHEMBL488653 Activity 94.0 nM
C[C@H]1CN(Cc2ccccc2)c2ccccc2[C@H](C)N1C(=O)NCc1ccccc1 CHEMBL3978731 IC50 95.0 nM
C[C@@H]1CN(Cc2cccnc2)c2ccccc2[C@H](C)N1C(=O)NCc1ccccc1 CHEMBL3950824 IC50 95.0 nM
CC(C)(C)C(=O)CN1CCC(CNC(=O)c2cc(Cl)cc(Cl)c2)CC1 CHEMBL493061 IC50 97.0 nM
C[C@@H]1CN(Cc2ccccn2)c2ccccc2[C@H](C)N1C(=O)NCc1ccccc1 CHEMBL3976890 IC50 97.0 nM
CC(C)(C)CCN1CCC(CNC(=O)C2(c3ccc(F)cc3)CCCCC2)CC1 CHEMBL493060 IC50 99.0 nM
COc1ccc2c(c1)[C@H](C)N(C(=O)Nc1cccnc1)[C@H](C)CN2Cc1ccccc1 CHEMBL3925393 IC50 100.0 nM
CC(CC(C)(C)C)N1CCC(CNC(=O)c2cc(Cl)cc(Cl)c2)CC1 CHEMBL494478 IC50 109.0 nM
O=C(NCc1ccccc1OCC(F)(F)F)c1nn(-c2ccccc2F)c(C2CC2)c1Br CHEMBL4204051 IC50 110.0 nM
CCC1(c2ccccc2)c2c(F)cccc2NC(=O)N1CC(F)(F)F CHEMBL1223392 Activity 111.0 nM
CCCCC1(C2CC2)c2cc(Cl)ccc2NC(=O)N1CC(F)(F)F CHEMBL1223092 Activity 111.0 nM
Cc1ccccc1CC(=O)Nc1ccn(Cc2ccccc2)n1 CHEMBL4215681 IC50 120.0 nM
C[C@@H](NC(=O)Cc1ccc(C(C)(C)C)cc1)c1ccc(Cl)cc1 CHEMBL1684925 IP 123.0 nM
COCC(=O)O[C@]1(CCN(C)CCCc2nc3ccccc3[nH]2)CCc2cc(F)ccc2[C@@H]1C(C)C CHEMBL45816 IC50 126.0 nM
CCC1(c2ccccc2)c2c(ccc(F)c2F)N(C(=O)c2ocnc2C)C(=O)N1CC(F)(F)F CHEMBL1222453 Activity 127.0 nM
COc1cccc2c1[C@H](C)N(C(=O)Nc1cccnc1)[C@H](C)CN2Cc1ccccc1 CHEMBL3917820 IC50 130.0 nM
CCC1(c2ccccc2)c2c(ccc(Cl)c2F)NC(=O)N1CC(F)(F)F CHEMBL1223391 Activity 132.0 nM
C[C@@H]1CN(Cc2ccccc2)c2cncc(F)c2[C@H](C)N1C(=O)Nc1cccnc1 CHEMBL3898062 IC50 133.0 nM
C[C@@H]1CN(Cc2ccccc2)c2cc(Br)ccc2[C@H](C)N1C(=O)Nc1cccnc1 CHEMBL3974104 IC50 137.0 nM
CCN1C[C@@H](C)N(C(=O)NCc2ccccc2)[C@@H](C)c2ccccc21 CHEMBL3950065 IC50 139.0 nM
CCC1(c2ccc(F)c(F)c2)c2cc(Cl)ccc2NC(=O)N1CC(F)(F)F CHEMBL1223249 Activity 141.0 nM
CC1(C)CC(CN2CCC(F)(CNC(=O)c3cc(Cl)cc(Cl)c3)CC2)CCO1 CHEMBL529445 Activity 145.0 nM
COc1cccc([C@@H](C)NC(=O)Cc2ccc(C(C)(C)C)cc2)c1 CHEMBL1684926 IP 146.0 nM
COc1ccc([C@@H](C)NC(=O)Cc2ccc(C(C)(C)C)cc2)cc1 CHEMBL1684927 IP 146.0 nM
[2H]C([2H])(c1ccccc1)N1C[C@@H](C)N(C(=O)Nc2cccnc2)[C@@H](C)c2ccncc21 CHEMBL3919009 IC50 148.0 nM
CCCC1(c2cccc(N3CCOCC3)c2)c2cc(Cl)ccc2NC(=O)N1CC(F)(F)F CHEMBL1223323 Activity 161.0 nM
C[C@H]1c2ccccc2N(Cc2ccccc2)CCN1C(=O)NCc1ccccc1 CHEMBL3890307 IC50 164.0 nM
CC(C)(C)C(F)CN1CCC(CNC(=O)c2cc(Cl)cc(Cl)c2)CC1 CHEMBL495303 IC50 169.0 nM
CCCC1(c2cccc(OC)c2)c2cc(Cl)ccc2NC(=O)N1CC(F)(F)F CHEMBL1223171 Activity 171.0 nM
CC(C)(C)CCN1CCC(CNC(=O)Nc2cccc(Cl)c2)(c2ccccc2)CC1 CHEMBL488294 Activity 185.0 nM
C[C@@H]1CN(Cc2ccccc2)c2nnccc2[C@H](C)N1C(=O)NCc1ccccc1 CHEMBL3961356 IC50 206.0 nM
C[C@@H]1CN(Cc2ccccc2)c2ccccc2[C@H](C)N1S(=O)(=O)c1cn(C)cn1 CHEMBL3923527 IC50 210.0 nM
O=C(NCc1ccccc1)N1CCN(Cc2ccccc2)c2ccccc2C1 CHEMBL3979642 IC50 214.0 nM
C[C@@H]1CN(c2ccccc2)c2ccccc2[C@H](C)N1C(=O)NCc1ccccc1 CHEMBL3969267 IC50 225.0 nM
C[C@@H](NC(=O)Cc1ccc(C(C)(C)C)cc1)c1ccccc1 CHEMBL1684920 IP 235.0 nM
C[C@@H]1CN(CC2CCCCO2)c2ccccc2[C@H](C)N1C(=O)Nc1cccnc1 CHEMBL3948466 IC50 243.0 nM
CC(C)CCN1C[C@@H](C)N(C(=O)Nc2cccnc2)[C@@H](C)c2ccncc21 CHEMBL3927924 IC50 251.0 nM
CC(C)(C)C(O)CN1CCC(CNC(=O)c2cc(Cl)cc(Cl)c2)CC1 CHEMBL495302 IC50 252.0 nM
COc1ccc([C@@H](C)NC(=O)Cc2ccc(Cl)c(Cl)c2)nc1 CHEMBL1684938 IP 252.0 nM
C[C@@H]1C(=O)N(Cc2ccccc2)c2ccccc2[C@H](C)N1C(=O)NCc1ccccc1 CHEMBL3899264 IC50 259.0 nM
Cc1nccnc1-c1ccc(CC(=O)N[C@H](C)c2ccc(OCC(F)(F)F)cn2)cc1 CHEMBL2151147 IC50 264.0 nM
CC(C)COc1ccccc1CNC(=O)c1c2c(c(Cl)n1C)CC(C(F)(F)F)CC2 CHEMBL4202418 IC50 270.0 nM
Cc1ccc(CN2CCC(CNC(=O)c3cc(Cl)cc(Cl)c3)CC2)cc1 CHEMBL488295 IC50 281.0 nM
C[C@@H]1CN(Cc2ccccc2)c2nc(C(F)(F)F)ccc2[C@H](C)N1C(=O)NCc1ccccc1 CHEMBL3916909 IC50 281.0 nM
CCCC1(c2ccc(F)cc2)c2c(ccc(F)c2F)NC(=O)N1CC(F)(F)F CHEMBL1223531 Activity 290.0 nM
C[C@@H]1CN(Cc2ccccc2)c2cnccc2[C@H](C)N1C(=O)Nc1cccnc1 CHEMBL3917185 IC50 306.0 nM
C[C@@H]1CN(Cc2ccccc2)c2cc(C#N)ccc2[C@H](C)N1C(=O)Nc1cccnc1 CHEMBL3944657 IC50 308.0 nM
CCCC1(c2cccc(-c3ccnn3C)c2)c2cc(Cl)ccc2NC(=O)N1CC(F)(F)F CHEMBL1223251 Activity 318.0 nM
Cn1c(Cl)c2c(c1C(=O)NCc1cccnc1OCC(F)(F)F)CCC(C)(C)C2 CHEMBL4213286 IC50 320.0 nM
C[C@@H]1CN(C(=O)NCc2ccccc2)[C@@H](C)c2ccccc2N1Cc1ccccc1 CHEMBL3904762 IC50 326.0 nM
CC(NC(=O)Cc1ccc(C(C)(C)C)cc1)c1ccccc1Cl CHEMBL1684924 IP 332.0 nM
O=C(Nc1ccc(F)cc1)N1N=C(c2ccncc2)CC1c1ccc(F)cc1 CHEMBL3892579 IC50 340.0 nM
COCc1ccc(CNC(=O)c2sc(Br)c3c2CCC(C)(C)C3)cc1 CHEMBL4217576 IC50 350.0 nM
CC(C)(C)CCN1CCC(CNC(=O)c2cccc(Cl)c2)CC1 CHEMBL493680 IC50 351.0 nM
CCOc1ccccc1CNC(=O)c1c2c(c(Cl)n1C)CC(C)(C)CC2 CHEMBL4213830 IC50 370.0 nM
CC(C)COc1ccccc1CNC(=O)c1c2c(c(Cl)n1C)C[C@H](C)[C@@H](C)C2 CHEMBL4214109 IC50 380.0 nM
O=C(Cc1ccccc1)Nc1ccn(Cc2ccccc2)n1 CHEMBL4202940 IC50 390.0 nM
CC(C)(C)CCN1CC[C@@H](CNC(=O)c2cc(Cl)cc(Cl)c2)[C@H](F)C1 CHEMBL521833 IC50 411.0 nM
CC(C)c1ccc(Cc2nnc(-c3ccn(Cc4ccc(F)c(F)c4)n3)[nH]2)cc1 CHEMBL4213632 IC50 420.0 nM
CC(NC(=O)Cc1ccc(C(C)(C)C)cc1)c1ccccn1 CHEMBL1684928 IP 427.0 nM
COc1ccc([C@@H](C)NC(=O)Cc2ccc(Oc3ccccc3)cc2)nc1 CHEMBL1684942 IP 439.0 nM
CCC(C)C1(C2CC2)c2cc(Cl)ccc2NC(=O)N1CC(F)(F)F CHEMBL1223093 Activity 447.0 nM
CC(C)COc1ccccc1CNC(=O)c1c2c(c(Cl)n1C)CCC2 CHEMBL4218528 IC50 460.0 nM
C[C@@H]1CN(Cc2ccccc2)c2ccccc2[C@H](C)N1C(=O)OCc1ccccc1 CHEMBL3936568 IC50 473.0 nM
CN(C)c1ccc(CC(=O)Nc2ccn(Cc3ccc(N4CCCC4=O)cc3)n2)cc1 CHEMBL4213764 IC50 520.0 nM
CCOCc1ccccc1CNC(=O)c1sc(Br)c2c1CCC(C)(C)C2 CHEMBL4210633 IC50 540.0 nM
O=C(NCC1CCN(Cc2ccc(Br)nc2)CC1)c1cc(Cl)cc(Cl)c1 CHEMBL523535 IC50 552.0 nM
COc1ccc2c(c1)N(Cc1ccccc1)C[C@@H](C)N(C(=O)Nc1cccnc1)[C@H]2C CHEMBL3947185 IC50 610.0 nM
CCOCc1ccc(CNC(=O)c2sc(C)c3c2C[C@H]2[C@@H]3C2(C)C)cc1 CHEMBL4209762 IC50 620.0 nM
C[C@@H]1c2ccccc2N(Cc2ccccc2)C[C@H](C)N1C(=O)NCc1ccccc1 CHEMBL3951718 IC50 641.0 nM
O=C(NCc1ccccc1OCC(F)(F)F)c1nn(-c2ccccc2)c(-c2ccccc2)c1CCO CHEMBL4213393 IC50 650.0 nM
CCC1(c2ccccc2)c2c(F)ccc(F)c2NC(=O)N1CC(F)(F)F CHEMBL1223393 Activity 657.0 nM
CCOCc1ccccc1CNC(=O)c1c2c(c(Cl)n1C)CC(C)(C)CC2 CHEMBL4215213 IC50 660.0 nM
CC(C)COc1ccccc1CNC(=O)c1c2c(c(Cl)n1C)CCC(C)(C)C2 CHEMBL4215580 IC50 700.0 nM
Cn1c(Cl)c2c(c1C(=O)NCc1ccccc1Cn1cccn1)CCC(C)(C)C2 CHEMBL4205453 IC50 710.0 nM
CCc1c(C)c(C(=O)NCc2ccccc2OCC(C)C)n(C)c1Cl CHEMBL4213589 IC50 710.0 nM
CC(C)OCc1ccccc1CNC(=O)c1c2c(c(Cl)n1C)CC(C)(C)CC2 CHEMBL4202587 IC50 740.0 nM
CC(C)(C)C1(c2ccccc2)c2cc(F)ccc2NC(=O)N1CC(F)(F)F CHEMBL1223463 Activity 757.0 nM
O=C(NCC1CCN(CCC2CC2)CC1)c1cc(Cl)cc(Cl)c1 CHEMBL494477 IC50 771.0 nM
COCc1ccccc1CNC(=O)c1sc(Br)c2c1CCC(C)(C)C2 CHEMBL4204934 IC50 810.0 nM
CCc1c(C)c(Cl)n(C)c1C(=O)NCc1ccccc1OCC(C)C CHEMBL4210232 IC50 810.0 nM
O=C(CC1c2ccccc2N=C(SCCCCCN2CCCC2)N1c1ccc(-c2ccccc2)cc1)NCc1ccccc1 CHEMBL4643629 IC50 810.0 nM
Fc1ccc(C(c2ccc(F)cc2)N2CCN(C/C=C/c3ccccc3)CC2)cc1 CHEMBL30008 Kd 840.0 nM
CCC1(c2ccccc2)c2cc(Cl)ccc2NC(=O)N1C CHEMBL1223025 Activity 847.0 nM
CCCC1(c2ccc(OC)cc2)c2cc(Cl)ccc2NC(=O)N1CC(F)(F)F CHEMBL1223170 Activity 879.0 nM
Cn1nc(C(=O)NCc2ccccc2OCC(F)(F)F)c(C(F)F)c1-c1ccccc1 CHEMBL4211471 IC50 890.0 nM
CC(C)COc1ccccc1CNC(=O)c1c2c(c(Cl)n1C)CN(C(=O)OC(C)(C)C)C2 CHEMBL4206782 IC50 890.0 nM
C[C@@H]1CN(Cc2ccccc2)c2ccccc2[C@H](C)N1C(=O)N(C)Cc1ccccc1 CHEMBL3951240 IC50 892.0 nM
O=C(NCc1ccccc1OCC(F)(F)F)c1nn(-c2ccccc2)c(-c2ccccc2)c1CCNC1CC1 CHEMBL4205063 IC50 900.0 nM
Cc1onc(CNC(=O)c2c3c(c(Cl)n2C)CC(C)(C)CC3)c1Cn1cccn1 CHEMBL4216691 IC50 910.0 nM
CC(C)c1ccc(CC(=O)N[C@H](C)c2ccc(O)cn2)cc1 CHEMBL1684947 IP 920.0 nM
Cn1c(Cl)c2c(c1C(=O)NCc1ccccc1Cn1cncn1)CCC(C)(C)C2 CHEMBL4217174 IC50 940.0 nM
CN(C)CCCCCSC1=Nc2ccccc2C(CC(=O)NCc2ccc(F)cc2)N1c1ccc(-c2ccc(F)cc2)cc1 CHEMBL4648577 IC50 960.0 nM
Cn1c(C#N)c2c(c1C(=O)NCc1cccnc1OCC(F)(F)F)CCC(C)(C)C2 CHEMBL4206268 IC50 980.0 nM
C[C@@H]1CN(Cc2ccccc2)c2cncnc2[C@H](C)N1C(=O)NCc1ccccc1 CHEMBL3924956 IC50 1000.0 nM