CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL388978 IC50 0.0311 nM
CCN(CC)[C@@H](C)CNC(=O)c1cc(NC)nc(-c2cnn3ccc(-c4cccs4)nc23)c1 CHEMBL4218769 IC50 0.05 nM
CCN(CC)[C@@H](C)CNC(=O)c1cc(-c2cnn3ccc(-c4cccs4)nc23)nc(N2CC[C@@H](O)C2)c1 CHEMBL4208018 IC50 0.06 nM
CCN(CC)[C@@H](C)CNC(=O)c1cc(-c2cnn3ccc(-c4cccs4)nc23)nc(N2CC[C@H](O)C2)c1 CHEMBL4215817 IC50 0.07 nM
CCN(CC)[C@@H](C)CNC(=O)c1cc(NCCOC)nc(-c2cnn3ccc(-c4cccs4)nc23)c1 CHEMBL4218245 IC50 0.08 nM
CCN(CC)[C@@H](C)CNC(=O)c1ccnc(-c2cnn3ccc(-c4cccs4)nc23)c1 CHEMBL4217261 IC50 0.09 nM
CCN(CC)[C@@H](C)CNC(=O)c1cc(NCCO)nc(-c2cnn3ccc(-c4cccs4)nc23)c1 CHEMBL4206514 IC50 0.1 nM
CCN(CC)[C@@H](C)CNC(=O)c1cc(-c2cnn3ccc(-c4cccs4)nc23)nc(N2CC(OC)C2)c1 CHEMBL4215300 IC50 0.1 nM
CCN(CC)[C@@H](C)CNC(=O)c1cc(-c2cnn3ccc(-c4cccs4)nc23)nc(N2CC(O)C2)c1 CHEMBL4210359 IC50 0.1 nM
CCN(CC)[C@@H](C)CNC(=O)c1cc(-c2cnn3ccc(-c4cccs4)nc23)nc(N2CCC(O)CC2)c1 CHEMBL4209816 IC50 0.22 nM
CCN(CC)[C@@H](C)CNC(=O)c1cc(-c2cnn3ccc(-c4cccs4)nc23)nc(N(C)C)c1 CHEMBL4213838 IC50 0.23 nM
CCN(CC)[C@@H](C)CNC(=O)c1cc(OCCOC)nc(-c2cnn3ccc(-c4cccs4)nc23)c1 CHEMBL4210881 IC50 0.28 nM
CCN(CC)[C@@H](C)CNC(=O)c1cc(-c2cnn3ccc(-c4cccs4)nc23)nc(N2CCOCC2)c1 CHEMBL4205997 IC50 0.3 nM
CCc1cc(C(=O)NC[C@H](C)N(CC)CC)cc(-c2cnn3ccc(-c4cccs4)nc23)n1 CHEMBL4209443 IC50 0.92 nM
CCN(CC)CCNC(=O)c1ccnc(-c2cnn3ccc(-c4cccs4)nc23)c1 CHEMBL4205708 IC50 1.6 nM
CN1CCCC1CCNc1nc(Nc2ccc(Cl)c(Cl)c2)nc2ccc(Cl)cc12 CHEMBL3216550 IC50 2.0 nM
CCn1c(N)c(C(N)=O)c(=O)c2cnc(Nc3ccc(N4CCC(N5CCOCC5)CC4)cc3OC)nc21 CHEMBL3699625 IC50 2.0 nM
CCN(CC)C[C@H](C)NC(=O)c1ccnc(-c2cnn3ccc(-c4cccs4)nc23)c1 CHEMBL4211430 IC50 2.17 nM
CCN(CC)CCNC(=O)c1cc(-c2cnn3ccc(-c4cccs4)nc23)c2nccn2c1 CHEMBL4213305 IC50 3.3 nM
CCN1CCC[C@H]1CNC(=O)c1ccnc(-c2cnn3ccc(-c4cccs4)nc23)c1 CHEMBL4209840 IC50 3.4 nM
CCN(CC)CCNC(=O)c1cccc(-c2cnn3ccc(-c4cccs4)nc23)c1 CHEMBL4210568 IC50 3.5 nM
COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 CHEMBL509032 pKi 3.981 nM
CCN(CC)CCNC(=O)c1cc(-c2cnn3ccc(-c4cccs4)nc23)c2ncn(C)c2c1 CHEMBL4208717 IC50 4.0 nM
CO[C@@H]1[C@H](NCCOCCOCCOCCNC(=O)CCC2=[N+]3C(=Cc4c(C)cc(C)n4[B-]3(F)F)C=C2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL4465866 Kd 4.0 nM
Cc1n[nH]c2cnc(-c3cncc(OCC(N)Cc4cccc(C(F)(F)F)c4)c3)cc12 CHEMBL1998159 pKi 5.012 nM
CCN(CC)CCNC(=O)c1cccc(-c2cnc3ccc(-c4cccs4)nn23)c1 CHEMBL4216080 IC50 5.8 nM
CO[C@@H]1[C@H](N(C)CCOCCOCCOCCNC(=O)CCC2=[N+]3C(=Cc4c(C)cc(C)n4[B-]3(F)F)C=C2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL4576489 Kd 6.0 nM
CCN(CC)[C@H](C)CNC(=O)c1ccnc(-c2cnn3ccc(-c4cccs4)nc23)c1 CHEMBL4213540 IC50 7.2 nM
CCn1c(N)c(C(N)=O)c(=O)c2cnc(Nc3ccc(N4CCC(N5CCCC5)CC4)c(Cl)c3)nc21 CHEMBL3699629 IC50 8.0 nM
C[C@]12O[C@H](C[C@]1(O)CO)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)CNC4=O CHEMBL603469 Kd 8.8 nM
Clc1cccc(Nc2nccc(-c3cccc(N4CCNCC4)c3)n2)c1 CHEMBL270849 IC50 9.0 nM
CCN(CC)CCCNC(=O)c1ccnc(-c2cnn3ccc(-c4cccs4)nc23)c1 CHEMBL4214345 IC50 9.1 nM
NCCc1cn(C2=C(c3c[nH]c4ccc(Cl)cc34)C(=O)NC2=O)c2ccccc12 CHEMBL255607 IC50 10.0 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4ccccc4)c3)cc12 CHEMBL2002726 pKi 10.0 nM
NCCNc1cccc(-c2ccnc(Nc3cccc(Cl)c3)n2)c1 CHEMBL272978 IC50 12.0 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4ccc(Cl)c(Cl)c4)c3)cc12 CHEMBL1991063 pKi 12.59 nM
CNCCc1cn(C2=C(c3c[nH]c4ccc(Cl)cc34)C(=O)NC2=O)c2ccccc12 CHEMBL402340 IC50 13.0 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4c[nH]c5ccccc45)c3)cc12 CHEMBL1970903 pKi 15.85 nM
NC(COc1cncc(-c2ccc3c(c2)C(=Cc2ccco2)C(=O)N3)c1)Cc1c[nH]c2ccccc12 CHEMBL2001751 pKi 15.85 nM
CCn1c(N)c(C(N)=O)c(=O)c2cnc(Nc3ccc(C4CCN(C5CC5)CC4)cc3OC)nc21 CHEMBL3699624 IC50 17.0 nM
CCN1CCN(Cc2ccc(Nc3ncc(F)c(-c4cc(F)c5nc(C)n(C(C)C)c5c4)n3)nc2)CC1 CHEMBL3301610 Kd apparent 19.0 nM
CNS(=O)(=O)c1ccccc1Nc1nc(Nc2cc(OC)c(OC)c(OC)c2)ncc1Cl CHEMBL1993661 pKi 19.95 nM
CNCCc1cn(C2=C(c3c[nH]c4ccc(C(=O)OC)cc34)C(=O)NC2=O)c2ccccc12 CHEMBL271648 IC50 21.0 nM
CCn1c(N)c(C(N)=O)c(=O)c2cnc(Nc3ccc(C4CCN(CCC(F)(F)F)CC4)cc3OC)nc21 CHEMBL3699626 IC50 22.0 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4cccc(OC(F)(F)F)c4)c3)cc12 CHEMBL1965836 pKi 25.12 nM
CCN(CC)CCNC(=O)c1c(C)[nH]c(C=C2C(=O)Nc3ccc(F)cc32)c1C CHEMBL1990885 pKi 25.12 nM
Cn1cc(Nc2ncc(Br)c(Nc3ccccc3C(N)=O)n2)cn1 CHEMBL1994669 pKi 31.62 nM
CN1CCN(c2nc(C3=C(c4c[nH]c5ccccc45)C(=O)NC3=O)c3ccccc3n2)CC1 CHEMBL565612 pKi 31.62 nM
NCCc1cn(C2=C(c3c[nH]c4ccc(C(F)(F)F)cc34)C(=O)NC2=O)c2ccccc12 CHEMBL402533 IC50 32.0 nM
NCCCn1cc(C2=C(c3c[nH]c4ccc(Br)cc34)C(=O)NC2=O)c2ccccc21 CHEMBL403446 IC50 34.0 nM
CO[C@@H]1[C@H](N(C)C(=O)c2ccccc2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL608533 Kd 36.0 nM
CCn1c(N)c(C(N)=O)c(=O)c2cnc(Nc3ccc4c(c3)CCNC4)nc21 CHEMBL3699630 IC50 37.0 nM
CN(C)CCNC(=O)c1cccc(-c2cnc3ccc(-c4cccs4)nn23)c1 CHEMBL4215541 IC50 37.0 nM
NCCc1cn(C2=C(c3c[nH]c4ccc(F)cc34)C(=O)NC2=O)c2ccccc12 CHEMBL403337 IC50 38.0 nM
COc1cc(C2CCNCC2)ccc1Nc1ncc2c(=O)c(C(N)=O)c(N)n(-c3ccccc3)c2n1 CHEMBL3699634 IC50 39.0 nM
NC1CCCCC1Nc1nccc(-c2c[nH]c3ncccc23)n1 CHEMBL1995813 pKi 39.81 nM
CCCCOc1ncnc2[nH]cc(-c3ccccc3)c12 CHEMBL1996817 pKi 39.81 nM
CC(C)N(CCNC(=O)c1cccc(-c2cnc3ccc(-c4cccs4)nn23)c1)C(C)C CHEMBL4211934 IC50 41.0 nM
O=C(O)c1ccc(-c2ccnc(Nc3cccc(Cl)c3)n2)cc1 CHEMBL271045 IC50 42.0 nM
CCN(CC)CCNC(=O)c1cccc(-c2cnc3ccc(-c4ccccc4)nn23)c1 CHEMBL4210073 IC50 44.0 nM
N#Cc1ccc2[nH]cc(C3=C(n4cc(CCN)c5ccccc54)C(=O)NC3=O)c2c1 CHEMBL270032 IC50 46.0 nM
CCN(CC)CCN(C)C(=O)c1ccnc(-c2cnn3ccc(-c4cccs4)nc23)c1 CHEMBL4209789 IC50 53.0 nM
COc1cc(C2CCNCC2)ccc1Nc1ncc2c(=O)c(C(N)=O)c(N)n(CCO)c2n1 CHEMBL3699635 IC50 57.0 nM
CN(C)CCNC(=O)c1cccc(-c2cnc3ccc(-n4cccc4)nn23)c1 CHEMBL4205405 IC50 57.0 nM
OC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1986943 pKi 63.1 nM
NC(=O)c1cccc(-c2cnc3[nH]cc(-c4ccccc4)c3c2)c1 CHEMBL1982957 pKi 63.1 nM
O=C(O)c1ccc(-c2ccnc(Nc3ccccc3)n2)cc1 CHEMBL402428 IC50 64.0 nM
CN(C)CCNC(=O)c1cccc(-c2cnc3ccc(-c4ccsc4)nn23)c1 CHEMBL4209139 IC50 65.0 nM
Nc1cc(Nc2nccc(-c3ccc(C(=O)O)cc3)n2)ccn1 CHEMBL255617 IC50 66.0 nM
OCC(CO)Nc1ncnc2[nH]cc(-c3ccccc3)c12 CHEMBL1992922 pKi 79.43 nM
O=C1Nc2ccc3ncsc3c2C1=CNc1ccc(S(=O)(=O)Nc2ccccn2)cc1 CHEMBL1973540 pKi 79.43 nM
NC(=O)c1ccc(-c2c[nH]c3nccc(Cl)c23)cc1 CHEMBL1982711 pKi 79.43 nM
Clc1cc(-c2c[nH]c3ncccc23)cc(NCc2ccccc2)n1 CHEMBL1969588 pKi 79.43 nM
CCN1CCCC(Nc2nc(Nc3cc(Cl)cc(Cl)c3)nc3ccc(Cl)cc23)C1 CHEMBL3215661 IC50 82.0 nM
N#CC[C@H](C1CCCC1)n1cc(-c2ncnc3[nH]ccc23)cn1 CHEMBL1789941 Kd 90.0 nM
Cn1cc(Nc2ncc(Cl)c(Nc3ccccc3C(N)=O)n2)cn1 CHEMBL1984548 pKi 100.0 nM
CCc1ccc2[nH]cc(C3=C(n4cc(CCNC)c5ccccc54)C(=O)NC3=O)c2c1 CHEMBL411724 IC50 110.0 nM
NCCc1cn(C2=C(c3c[nH]c4ccccc34)C(=O)NC2=O)c2ccccc12 CHEMBL430412 IC50 110.0 nM
CCn1c(N)c(C(N)=O)c(=O)c2cnc(Nc3ccc(OC4CCN(C)CC4)cc3)nc21 CHEMBL3699631 IC50 118.0 nM
CCN(CC)C[C@@H](C)NC(=O)c1ccnc(-c2cnn3ccc(-c4cccs4)nc23)c1 CHEMBL4204410 IC50 125.0 nM
N#CCOc1ccc(Nc2nc(Nc3cccc(S(N)(=O)=O)c3)ncc2Br)cc1 CHEMBL1987034 pKi 125.89 nM
N#Cc1ccc(-c2n[nH]c3c2Cc2ccc(OCCCCN4CCOCC4)cc2-3)cn1 CHEMBL398951 pKi 125.89 nM
Cc1cc(Nc2ncc(F)c(NC3C4C=CC(C4)C3C(N)=O)n2)ccc1N1CCN(C)CC1 CHEMBL1967878 pKi 125.89 nM
CNC(=O)NC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL2005509 pKi 125.89 nM
CC(C)Cn1c(N)c(C(N)=O)c(=O)c2cnc(Nc3ccc(CCN4CCOCC4)cc3)nc21 CHEMBL3699627 IC50 139.0 nM
CNCCc1cn(C2=C(c3c[nH]c4ccccc34)C(=O)NC2=O)c2ccccc12 CHEMBL402152 IC50 150.0 nM
CCCCCNc1nc(Nc2ccc([N+](=O)[O-])cc2)nc(N2CCN(CCN(C)C)CC2)n1 CHEMBL1939328 IC50 154.0 nM
CCC1C(=O)N(C)c2cnc(Nc3ccc(C(=O)NC4CCN(C)CC4)cc3OC)nc2N1C1CCCC1 CHEMBL1968380 pKi 158.49 nM
NCCCn1cc(-c2cc(-c3cc4ccccc4s3)c3[nH]ncc3c2)c2nc(N)ncc21 CHEMBL592030 pKi 158.49 nM
OCCCNc1ncnc2[nH]cc(-c3ccccc3)c12 CHEMBL2000071 pKi 158.49 nM
Cc1n[nH]c2ccc(-c3cncc(OCCN)c3)cc12 CHEMBL1967887 pKi 158.49 nM
CCNC(=O)NC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1992220 pKi 158.49 nM
C[C@H](Nc1cc(Nc2nccc(-c3ccc(C(=O)NO)cc3)n2)ccn1)c1ccccc1 CHEMBL402524 IC50 170.0 nM
COc1ccc2[nH]cc(C3=C(n4cc(CCN)c5ccccc54)C(=O)NC3=O)c2c1 CHEMBL271426 IC50 170.0 nM
NCCCn1cc(C2=C(c3cccc(Br)c3)C(=O)NC2=O)c2ccccc21 CHEMBL412302 IC50 180.0 nM
CNCCc1cn(C2=C(c3c[nH]c4ccc(C(N)=O)cc34)C(=O)NC2=O)c2ccccc12 CHEMBL271043 IC50 190.0 nM
NCCCc1cn(C2=C(c3c[nH]c4ccccc34)C(=O)NC2=O)c2ccccc12 CHEMBL270141 IC50 190.0 nM
COC(=O)[C@@]1(O)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL281948 Kd apparent 190.0 nM
O=C(NCCN1CCCC1)c1cccc(-c2cnc3ccc(-c4cccs4)nn23)c1 CHEMBL4218994 IC50 191.0 nM
NS(=O)(=O)c1cccc(Nc2ncc3ccn(-c4ccccc4)c3n2)c1 CHEMBL1988163 pKi 199.53 nM
COc1ccc(C(=O)N2c3ccccc3Sc3c(Cl)cncc32)cc1 CHEMBL1988537 pKi 199.53 nM
S=c1[nH]nc2c3c4c(sc3n3c(=S)[nH]nc3n12)CCC4 CHEMBL1969537 pKi 199.53 nM
CC(=O)NCC(=O)N1C2CCC1c1cc(Nc3ncc(C(F)(F)F)c(NC4CCC4)n3)ccc12 CHEMBL1983111 pKi 199.53 nM
Cc1cccc(NC(=O)Nc2ccc(NC(=O)c3csc4ncnc(N)c34)cc2)c1 CHEMBL1965507 pKi 199.53 nM
CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)c(OC)c2)nc1NC1CCOCC1 CHEMBL3301622 Kd apparent 207.0 nM
C[C@H](Nc1cc(Nc2nccc(-c3ccc(C(=O)O)cc3)n2)ccn1)c1ccccc1 CHEMBL403766 IC50 210.0 nM
NCCCn1cc(C2=C(c3ccccc3)C(=O)NC2=O)c2ccccc21 CHEMBL256827 IC50 230.0 nM
Clc1cccc(Nc2nccc(-c3cccc(N4CCOCC4)c3)n2)c1 CHEMBL403054 IC50 240.0 nM
CN(C)CCNC(=O)c1cccc(-c2cnc3ccc(-c4ccccc4)nn23)c1 CHEMBL4214991 IC50 245.0 nM
O=C(O)c1ccccc1Nc1ccnc(Nc2ccc3cn[nH]c3c2)n1 CHEMBL244378 pKi 251.19 nM
Cc1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3-c3ccc(F)cc3)cc12 CHEMBL1972339 pKi 251.19 nM
NC1CCCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)C1 CHEMBL1998432 pKi 251.19 nM
CS(=O)(=O)N(Cc1ccc2[nH]c(=O)c3cccn3c2c1)C1CC1 CHEMBL1978448 pKi 251.19 nM
NC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1973720 pKi 251.19 nM
CCN(CC)CCNC(=O)c1cc(-c2cnn3ccc(-c4cccs4)nc23)n2ccnc2c1 CHEMBL4215635 IC50 254.0 nM
CCn1c(N)c(C(N)=O)c(=O)c2cnc(Nc3ccc(C(=O)N4CCN(C)CC4)cc3)nc21 CHEMBL3699623 IC50 260.0 nM
CCn1c(N)c(C(N)=O)c(=O)c2cnc(Nc3cccc(CN(C)C)c3)nc21 CHEMBL3699632 IC50 268.0 nM
Cc1n[nH]c2ccc(-c3cncc(OC[C@@H](N)Cc4ccccc4)c3)cc12 CHEMBL379218 Kd 270.0 nM
Cc1cccc(C2=C(c3cn(CCCN)c4ccccc34)C(=O)NC2=O)c1 CHEMBL408434 IC50 280.0 nM
CNCCc1cn(C2=C(c3c[nH]c4ccc(C(=O)NC)cc34)C(=O)NC2=O)c2ccccc12 CHEMBL256460 IC50 280.0 nM
O=C(NO)c1ccc(-c2ccnc(Nc3ccccc3)n2)cc1 CHEMBL255633 IC50 290.0 nM
NCCCn1cc(C2=C(c3cccc4ccccc34)C(=O)NC2=O)c2ccccc21 CHEMBL411253 IC50 290.0 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(N4CCNCC4)cn3)nc2n1C1CCCC1 CHEMBL3545110 Kd apparent 293.0 nM
Cn1cc(C2=C(c3cn(C4CCCNC4)c4ccccc34)C(=O)NC2=O)c2ccccc21 CHEMBL409856 IC50 300.0 nM
Cn1cc(C2=C(c3cn(CCCN)c4ccccc34)C(=O)NC2=O)c2ccccc21 CHEMBL269264 IC50 310.0 nM
CCS(=O)(=O)N1CC(CC#N)(n2cc(-c3ncnc4[nH]ccc34)cn2)C1 CHEMBL2105759 Kd apparent 312.0 nM
CN1CCN(c2ccc3nc(-c4c(N)c5c(F)cccc5[nH]c4=O)[nH]c3c2)CC1 CHEMBL522892 pKi 316.23 nM
CNC(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCOCC3)cc2OC)ncc1Cl CHEMBL458997 pKi 316.23 nM
Brc1cnc2[nH]cc(-c3ccccc3)c2c1 CHEMBL1992634 pKi 316.23 nM
CC(C)(CN)CNc1nc(Cl)cc(-c2c[nH]c3ncccc23)n1 CHEMBL1968930 pKi 316.23 nM
COc1ccc(CNc2cc(-c3c[nH]c4ncccc34)cc(F)n2)cc1 CHEMBL1986855 pKi 316.23 nM
O=C(NCCN1CCNCC1)c1cccc(-c2cnc3ccc(-c4cccs4)nn23)c1 CHEMBL4207271 IC50 325.0 nM
Cc1nc(Nc2n[nH]c3c2CN(C(=O)N[C@H](CN(C)C)c2ccccc2)C3(C)C)c2sccc2n1 CHEMBL3128043 Kd apparent 343.0 nM
NCCCn1cc(C2=C(c3csc4ccccc34)C(=O)NC2=O)c2ccccc21 CHEMBL258290 IC50 360.0 nM
NCCCn1cc(C2=C(c3c[nH]c4ccccc34)C(=O)NC2=O)c2ccccc21 CHEMBL270875 IC50 380.0 nM
CNCCc1cn(C2=C(c3c[nH]c4ccc(C(=O)O)cc34)C(=O)NC2=O)c2ccccc12 CHEMBL271254 IC50 380.0 nM
NCCCn1nc(C2=C(c3c[nH]c4ccccc34)C(=O)NC2=O)c2ccccc21 CHEMBL271902 IC50 380.0 nM
CN([C@@H](Cc1ccc(OS(=O)(=O)c2cccc3cnccc23)cc1)C(=O)N1CCN(c2ccccc2)CC1)S(=O)(=O)c1cccc2cnccc12 CHEMBL28324 IC50 380.0 nM
O=C(O)c1ccc(-c2ccnc(Nc3ccncc3)n2)cc1 CHEMBL256632 IC50 390.0 nM
CCc1cc(N2CCN(C3CC3)CC2)ccc1Nc1ncc2c(=O)c(C(N)=O)c(N)n(CC)c2n1 CHEMBL3699633 IC50 396.0 nM
CC(C)(CN)CNc1cc(-c2c[nH]c3ncccc23)cc(F)n1 CHEMBL1987261 pKi 398.11 nM
Clc1cc(-c2c[nH]c3ncccc23)nc(NC2CCOCC2)n1 CHEMBL1980253 pKi 398.11 nM
CNCC(=O)NC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1996980 pKi 398.11 nM
Cc1cccc(Nc2nc(NC3CCCCC3N)cnc2C(N)=O)c1 CHEMBL1974328 pKi 398.11 nM
CS(=O)(=O)NC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1980562 pKi 398.11 nM
O=c1[nH]c2cnc(-n3cnc4ccc(F)cc43)nc2n1C1CCOc2c(F)cccc21 CHEMBL2000393 pKi 398.11 nM
O=C1NC(=O)c2c1c(-c1ccccc1Cl)cc1[nH]c3ccc(O)cc3c21 CHEMBL379975 pKi 398.11 nM
CCCCCNc1nc(Nc2ccc(Cl)cc2)nc(N2CCN(CCN(C)C)CC2)n1 CHEMBL1939327 IC50 401.0 nM
CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C CHEMBL535 Kd 420.0 nM
NCC(O)Cn1cc(C2=C(c3ccccc3)C(=O)NC2=O)c2ccccc21 CHEMBL404077 IC50 450.0 nM
O=C(NCCO)c1cccc(-c2cnc3ccc(-c4cccs4)nn23)c1 CHEMBL4211112 IC50 454.0 nM
O=C(NCCN1CCOCC1)c1cccc(-c2cnc3ccc(-c4cccs4)nn23)c1 CHEMBL4205811 IC50 474.0 nM
NCCCn1cc(C2=C(c3ccc4ccccc4c3)C(=O)NC2=O)c2ccccc21 CHEMBL409834 IC50 500.0 nM
CCn1c(C)c(-c2ccnc(Nc3cccc(OC)c3)n2)sc1=O CHEMBL1986263 pKi 501.19 nM
CC(C)(CN)CNc1cc(-c2c[nH]c3ncccc23)cc(Cl)n1 CHEMBL1985723 pKi 501.19 nM
Nc1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3-c3ccccc3)cc12 CHEMBL1972158 pKi 501.19 nM
NS(=O)(=O)c1cccc(Nc2ncc3ccn(Cc4ccccc4)c3n2)c1 CHEMBL1993424 pKi 501.19 nM
COc1cc(-c2ccc3c(c2)Nc2ccc(C(=O)NCCNC(C)=O)cc2NC3=O)ccc1O CHEMBL1975500 pKi 501.19 nM
O=C(Nc1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12)c1ccccc1 CHEMBL1999931 pKi 501.19 nM
O=C(Nc1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12)c1cccc(F)c1 CHEMBL2003638 pKi 501.19 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)N[C@H]4O CHEMBL574737 Kd apparent 520.0 nM
NCCCn1cc(C2=C(c3cccnc3)C(=O)NC2=O)c2ccccc21 CHEMBL407464 IC50 540.0 nM
CN(C)CCc1cn(C2=C(c3c[nH]c4ccccc34)C(=O)NC2=O)c2ccccc12 CHEMBL256872 IC50 560.0 nM
Cc1cnc(Nc2ccc(OCCN3CCCC3)cc2)nc1Nc1cccc(S(=O)(=O)NC(C)(C)C)c1 CHEMBL1287853 Kd 590.0 nM
CN(C)C1CCC(Nc2nc(Nc3cc(Cl)cc(Cl)c3)nc3ccccc23)CC1 CHEMBL1939163 IC50 619.0 nM
C[C@@H](Oc1cc(-n2cnc3ccc(CN4CCN(C)CC4)cc32)sc1C(N)=O)c1ccccc1C(F)(F)F CHEMBL1908394 Kd 620.0 nM
NCCCn1cc(C2=C(c3ccnc4ccccc34)C(=O)NC2=O)c2ccccc21 CHEMBL402775 IC50 630.0 nM
CC(=O)NC1CCCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)C1 CHEMBL1980178 pKi 630.96 nM
O=C(Nc1cnc2[nH]cc(-c3ccccc3)c2c1)c1c(F)cccc1F CHEMBL1996979 pKi 630.96 nM
Cc1cc(Cl)ccc1NC(=S)NNC(=O)C(O)(c1ccccc1)c1ccccc1 CHEMBL1988173 pKi 630.96 nM
NCC1CCC(CNc2nc(NCc3ccccc3Cl)ncc2[N+](=O)[O-])CC1 CHEMBL246970 pKi 630.96 nM
Cc1cc(C)c(C=C2C(=O)Nc3ccccc32)[nH]1 CHEMBL2002702 pKi 630.96 nM
CN(C)CC(=O)NC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1982271 pKi 630.96 nM
O=C(O)c1ccccc1Nc1ccnc(Nc2ccc3[nH]ncc3c2)n1 CHEMBL396523 pKi 630.96 nM
CS(=O)(=O)NC1CCCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)C1 CHEMBL1987948 pKi 630.96 nM
Cn1cc(C2=C(c3cn(C4CCNCC4)c4ccccc34)C(=O)NC2=O)c2ccccc21 CHEMBL55788 IC50 640.0 nM
Nc1cccc(-c2ccnc(Nc3cccc(Cl)c3)n2)c1 CHEMBL273008 IC50 660.0 nM
CN(C)Cc1ccc(Nc2ncc3c(=O)c(C(N)=O)c(N)n(CC(F)(F)F)c3n2)cc1 CHEMBL3699628 IC50 663.0 nM
N#CCNC(=O)c1ccc(-c2ccnc(Nc3ccc(N4CCOCC4)cc3)n2)cc1 CHEMBL1078178 Kd apparent 666.0 nM
O=C1NC(=O)C(n2cc(C3CCNCC3)c3ccccc32)=C1c1c[nH]c2ccccc12 CHEMBL270846 IC50 680.0 nM
C[C@H]1CN(c2cccc3nc(-c4nc(-c5cc(C(=O)N(C)C)ccn5)cnc4N)n(C)c23)CCN1 CHEMBL3800585 IC50 690.0 nM
COc1cccc(Nc2ncnn3ccc(CN4CC[C@@H](N)[C@H](O)C4)c23)c1 CHEMBL3545396 Kd apparent 703.0 nM
COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncnc(Nc2ccccc2S(=O)(=O)C(C)C)n1 CHEMBL3545360 Kd apparent 704.0 nM
CNC(=O)c1ccc(-c2ccnc(Nc3ccnc(N[C@@H](C)c4ccccc4)c3)n2)cc1 CHEMBL402741 IC50 720.0 nM
CN(C)CCCc1cn(C2=C(c3c[nH]c4ccccc34)C(=O)NC2=O)c2ccccc12 CHEMBL271695 IC50 740.0 nM
Cc1c(C2=C(c3c[nH]c4ccccc34)C(=O)NC2=O)c2ccccc2n1CCCN CHEMBL401681 IC50 740.0 nM
Cc1[nH]c2ccccc2c1C1=C(c2cn(CCCN)c3ccccc23)C(=O)NC1=O CHEMBL256265 IC50 750.0 nM
Cc1[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c(C)c1C(=O)NC[C@H](O)CN1CCOCC1 CHEMBL1721885 Kd 760.0 nM
c1ccc(Nc2nccc(-c3ccc(-c4nnn[nH]4)cc3)n2)cc1 CHEMBL404090 IC50 770.0 nM
CC(C)(CNc1cc(-c2c[nH]c3ncccc23)cc(Cl)n1)CNS(C)(=O)=O CHEMBL1971172 pKi 794.33 nM
CS(=O)(=O)NCCNc1cc(-c2c[nH]c3ncccc23)cc(Cl)n1 CHEMBL2005718 pKi 794.33 nM
CN(C)CCCOc1cc2c(c(-c3ccc(Nc4nc5ccccc5o4)cc3)c1)CNC2=O CHEMBL1966425 pKi 794.33 nM
O=C(O)c1c2c(nc3ccccc13)C(=C1CCCC1)CC2 CHEMBL1996831 pKi 794.33 nM
COc1ccc(C(=O)Nc2n[nH]c3ccc(-c4cn(Cc5ccccc5)nn4)cc23)cc1OC CHEMBL1991078 pKi 794.33 nM
Cc1ccc(NC(=O)Nc2ccc(-c3csc4ncnc(N)c34)cc2)cc1C CHEMBL2000335 pKi 794.33 nM
Cc1ccc(NC(=O)Nc2ccc(NC(=O)c3csc4ncnc(N)c34)cc2)cc1 CHEMBL1972576 pKi 794.33 nM
N#CC1=C(N)n2c(sc(=Cc3ccco3)c2=O)=C(C(N)=O)C1c1ccco1 CHEMBL1989805 pKi 794.33 nM
O=C1NCCc2[nH]c(-c3ccnc(-c4cnc5ccccc5c4)c3)cc21 CHEMBL226403 pKi 794.33 nM
CSc1ccccc1CNc1ncc([N+](=O)[O-])c(NCC2CCC(CN)CC2)n1 CHEMBL392642 pKi 794.33 nM
COc1cc(-c2cn[nH]c2)ccc1C(=O)Nc1ccc2c(c1)CCNCC2 CHEMBL5303487 IC50 810.0 nM
CC1(COc2ccc3c(c2)ncn3-c2ccc3cccc(N4CCC(N)CC4)c3n2)COC1 CHEMBL2105728 Kd apparent 821.0 nM
Cn1cc(C2=C(c3c[nH]c4ccc(Br)cc34)C(=O)NC2=O)c2ccccc21 CHEMBL256452 IC50 870.0 nM
Cc1cccc(-c2ccnc(Nc3ccnc(N[C@@H](C)c4ccccc4)c3)n2)c1 CHEMBL271278 IC50 920.0 nM
Clc1cccc(Nc2nccc(-c3cccc(N4CCCCC4)c3)n2)c1 CHEMBL403053 IC50 930.0 nM
CO[C@@H]1[C@H](N(C)C(=O)c2ccccc2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)N[C@H]4O CHEMBL1240703 Kd 1000.0 nM
Cc1cc(N2CCOCC2)cc2[nH]c(-c3c(NCC(O)c4cccc(Cl)c4)cc[nH]c3=O)nc12 CHEMBL2005886 pKi 1000.0 nM
Cc1nc2ccc(NS(=O)(=O)c3ccc(N)cc3)cc2nc1C CHEMBL2006263 pKi 1000.0 nM
CC(C)CNC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL2006456 pKi 1000.0 nM
COc1cc(-c2ccc3c(c2)Nc2ccc(C(=O)NCc4cccc(F)c4)cc2NC3=O)ccc1O CHEMBL2000832 pKi 1000.0 nM
NCCNc1cc(-c2c[nH]c3ncccc23)cc(Cl)n1 CHEMBL1972290 pKi 1000.0 nM
NC(COc1cncc(-c2ccc3c(c2)CC(=O)N3)c1)Cc1c[nH]c2ccccc12 CHEMBL1967302 pKi 1000.0 nM
Cc1nc(N)sc1-c1ccnc(Nc2ccc(N3CCOCC3)cc2)n1 CHEMBL482967 pKi 1000.0 nM
Oc1c2ccccc2c2c3c(cccc13)N=N2 CHEMBL1725279 pKi 1000.0 nM
CCCC(=O)Nc1cccc(-c2nc(Nc3ccc4[nH]ncc4c3)c3cc(OCCN4CCCC4)ccc3n2)c1 CHEMBL1968705 pKi 1000.0 nM
CN1C(=O)[C@@H](N2CCc3cn(CC4CCS(=O)(=O)CC4)nc3C2=O)COc2ccccc21 CHEMBL4097778 pIC50 1000.0 nM