CS(=O)(=O)N[C@H](COCc1ccccc1)C(=O)N[C@H](C=O)CCCCNS(=O)(=O)c1ccccc1 CHEMBL89100 Ki 2.0 nM
CCCCNC(=O)C(=O)[C@H](Cc1ccccc1)NC(=O)C1Cc2cc3c(cc2S(=O)(=O)N1CC)OCCO3 CHEMBL8651 IC50 2.1 nM
CCCCCC/C=C\CC(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](CO)[C@@H](O)CC(=O)N[C@H](C(=O)N[C@@H]1/C=C/C(=O)N[C@@H](C(C)C)C(=O)N(C)[C@@H](Cc2ccc(O)cc2)C(=O)OC1)C(C)C)C(C)C CHEMBL4073900 IC50 3.0 nM
CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)C(=O)O CHEMBL314442 Ki 3.4 nM
CS(=O)(=O)N[C@H](COCc1ccccc1)C(=O)N[C@H](C=O)Cc1ccc(OCc2ccccc2)cc1 CHEMBL91991 Ki 4.0 nM
CC(C)C[C@@H](C=O)NC(=O)[C@@H](NC(=O)OCc1ccccc1)C(C)(C)C CHEMBL151521 IC50 4.0 nM
CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@H](C=O)C(C)C CHEMBL150600 IC50 4.0 nM
CN1C(C(=O)N[C@H](C=O)Cc2ccccc2)Cc2cc(Cl)ccc2S1(=O)=O CHEMBL117553 IC50 5.0 nM
CCN1C(C(=O)N[C@H](C=O)Cc2ccccc2)Cc2cc(Cl)ccc2S1(=O)=O CHEMBL8378 IC50 5.0 nM
CC(C)C[C@H](C=O)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](C)NC(=O)OCc1ccccc1 CHEMBL357595 IC50 5.0 nM
CCCC[C@@H](C=O)NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1 CHEMBL92708 IC50 5.0 nM
CN1C(C(=O)N[C@H](C=O)Cc2ccccc2)=Cc2cc3c(cc2S1(=O)=O)OCCO3 CHEMBL326161 IC50 6.0 nM
CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)C(=O)NOCc1ccccc1 CHEMBL299750 IC50 6.0 nM
CS(=O)(=O)N[C@H](CSCc1ccccc1)C(=O)N[C@H](C=O)Cc1ccccc1 CHEMBL92114 Ki 6.0 nM
NC(=O)C(=O)C(Cc1ccccc1)NC(=O)c1ccccc1/C=C/c1ccc2ccccc2c1 CHEMBL280587 Ki 6.0 nM
CC(C)C[C@@H](C=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](C)NC(=O)OCc1ccccc1 CHEMBL345338 IC50 6.0 nM
CC(C)CC(NC(=O)OCc1ccccc1)C(=O)N[C@H](CC(C)C)C(=O)O CHEMBL127231 IC50 7.0 nM
CN1C(C(=O)N[C@H](C=O)Cc2ccccc2)Cc2cc(Cl)c(Cl)cc2S1(=O)=O CHEMBL118688 IC50 7.0 nM
CCN1C(C(=O)N[C@H](C=O)Cc2ccccc2)Cc2cc3c(cc2S1(=O)=O)OCCO3 CHEMBL269384 IC50 7.0 nM
O=C[C@H](Cc1ccccc1)NC(=O)C1Cc2ccccc2S(=O)(=O)N1 CHEMBL8605 IC50 7.0 nM
CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@H](C=O)Cc1ccc(OCc2ccccc2)cc1 CHEMBL423222 IC50 7.0 nM
CC(C)C[C@H](C=O)NC(=O)[C@@H](NS(=O)(=O)c1ccc(F)cc1)C(C)C CHEMBL168471 IC50 7.5 nM
CCN1C(C(=O)N[C@H](C=O)Cc2ccccc2)=Cc2cc3c(cc2S1(=O)=O)OCCO3 CHEMBL269333 IC50 8.0 nM
CS(=O)(=O)N[C@H](COCc1ccccc1)C(=O)N[C@H](C=O)Cc1ccccc1 CHEMBL315636 Ki 8.0 nM
CC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@H](C=O)Cc1ccccc1 CHEMBL286722 Ki 8.0 nM
N#Cc1cccc(-c2ccc(S(=O)(=O)NCCNC(=O)C(=O)[C@H](Cc3ccccc3)NC(=O)c3c(Cl)cccc3Cl)s2)c1 CHEMBL305715 Ki 8.0 nM
CC(C)C[C@@H](C=O)NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccc([N+](=O)[O-])cc1 CHEMBL347742 IC50 8.0 nM
CC(C)C[C@@H](C=O)NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1 CHEMBL356841 IC50 8.0 nM
CC(C)C[C@H](C=O)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)OCc1ccccc1 CHEMBL345337 IC50 8.0 nM
NC(=O)C(=O)C(Cc1ccccc1)NC(=O)c1cccnc1-n1cc2c(n1)-c1ccccc1OC2 CHEMBL4092996 Ki 8.0 nM
NC(=O)C(Cc1ccccc1)NC(=O)c1ccccc1/C=C/c1cccc2ccccc12 CHEMBL310855 Ki 8.4 nM
O=C[C@H](Cc1ccccc1)NC(=O)[C@@H](COCc1ccccc1)NS(=O)(=O)c1cccs1 CHEMBL90661 Ki 9.0 nM
CS(=O)(=O)N[C@@H](C(=O)N[C@H](C=O)Cc1ccccc1)c1ccccc1 CHEMBL88484 Ki 9.0 nM
CCS(=O)(=O)N[C@H](COCc1ccccc1)C(=O)N[C@H](C=O)Cc1ccccc1 CHEMBL89008 Ki 9.0 nM
CC(OCc1ccccc1)[C@@H](NS(C)(=O)=O)C(=O)N[C@H](C=O)Cc1ccccc1 CHEMBL89766 Ki 9.0 nM
NC(=O)C(=O)C(Cc1ccccc1)NC(=O)C1CCN(C(=O)c2cc3ccccc3s2)CC1 CHEMBL407974 Ki 9.0 nM
NC(=O)C(=O)C(Cc1ccccc1)NC(=O)C1CCN(c2cc3ccccc3s2)CC1 CHEMBL4167219 Ki 9.0 nM
CC(C)C[C@H](C=O)NC(=O)[C@@H](NS(=O)(=O)c1ccc2ccccc2c1)C(C)C CHEMBL168909 IC50 10.0 nM
CONC(=O)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1 CHEMBL89668 IC50 10.0 nM
CS(=O)(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C=O)Cc1ccccc1 CHEMBL420423 Ki 10.0 nM
CC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)NC(C=O)Cc1ccccc1 CHEMBL423112 Ki 10.0 nM
CS(=O)(=O)N[C@H](COCc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)C(=O)NCCNS(=O)(=O)c1ccc(-c2ccccn2)s1 CHEMBL78843 Ki 10.0 nM
CC(C)C[C@@H](C=O)NC(=O)[C@H](CC(C)C)NS(C)(=O)=O CHEMBL151536 IC50 10.0 nM
CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@H](C=O)Cc1ccccc1 CHEMBL341014 IC50 10.0 nM
CC(C)C[C@H](NC(=O)c1ccc2ccccc2c1)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](C=O)CC(C)C CHEMBL150134 IC50 10.0 nM
CC[C@@H](C=O)NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1 CHEMBL2371036 IC50 10.0 nM
NC(=O)C(=O)[C@H](Cc1ccccc1)NC(=O)c1cccnc1-n1ccc(-c2ccccc2)n1 CHEMBL4094671 Ki(app) 10.0 nM
CS(=O)(=O)NC(COCc1ccccc1)C(=O)N[C@H](C=O)Cc1ccccc1 CHEMBL117639 IC50 11.0 nM
CS(=O)(=O)N[C@H](Cc1ccccc1)C(=O)N[C@H](C=O)Cc1ccccc1 CHEMBL88646 Ki 11.0 nM
CS(=O)(=O)N[C@H](Cc1cccs1)C(=O)N[C@H](C=O)Cc1ccccc1 CHEMBL88895 Ki 11.0 nM
CS(=O)(=O)N[C@H](CS(=O)(=O)Cc1ccccc1)C(=O)N[C@H](C=O)Cc1ccccc1 CHEMBL90811 Ki 11.0 nM
CC(C)[C@H](N)C(=O)N[C@@H](Cc1ccccc1)C(=O)O CHEMBL8486 IC50 11.0 nM
CC(C)C[C@H](C=O)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 CHEMBL151370 IC50 11.0 nM
CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@H](C=O)CC1CCCCC1 CHEMBL151829 IC50 11.0 nM
CC(C)C[C@@H](C=O)NC(=O)[C@H](CC(C)C)NC(=O)OCC1c2ccccc2-c2ccccc21 CHEMBL149754 IC50 11.0 nM
CC(C)[C@@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)C(=O)NOCc1ccccc1 CHEMBL316418 IC50 12.0 nM
CC(C)C[C@H](C=O)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](COC(C)(C)C)NC(=O)OCc1ccccc1 CHEMBL150976 IC50 12.0 nM
CCCC[C@H](C=O)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O CHEMBL151937 IC50 12.0 nM
COC(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C=O)CC(C)C CHEMBL358404 IC50 12.0 nM
CC(C)[C@H](NS(=O)(=O)c1ccc(Cl)cc1)C(=O)N[C@@H](C=O)Cc1c[nH]c2ccccc12 CHEMBL169598 IC50 13.0 nM
O=C[C@H](Cc1ccccc1)NC(=O)[C@@H]1C[C@@H](OS(=O)(=O)c2ccccc2)CN1S(=O)(=O)c1ccccc1 CHEMBL87146 IC50 13.0 nM
CCCCC(NC(=O)c1ccccc1/C=C/c1ccc(CN(C)C)cc1)C(N)=O CHEMBL77784 Ki 13.3 nM
CC(C)[C@H](NS(=O)(=O)c1ccc2ccccc2c1)C(=O)N[C@@H](C=O)Cc1ccccc1 CHEMBL169307 IC50 14.0 nM
CC(C)[C@H](NS(=O)(=O)c1ccc(Cl)cc1)C(=O)N[C@@H](C=O)Cc1ccccc1 CHEMBL167224 IC50 14.0 nM
O=C(NCCNS(=O)(=O)c1ccc(-c2ccccn2)s1)C(=O)[C@H](Cc1ccccc1)NC(=O)c1c(F)cccc1F CHEMBL80867 Ki 14.0 nM
CC(=O)NCc1cccc(-c2ccc(S(=O)(=O)NCCNC(=O)C(=O)[C@H](Cc3ccccc3)NC(=O)c3c(Cl)cccc3Cl)s2)c1 CHEMBL311512 Ki 14.0 nM
Cc1ccc(S(=O)(=O)N2CCC[C@@H]2C(=O)N[C@H](C=O)Cc2ccccc2)cc1 CHEMBL316010 IC50 14.0 nM
CN1C(C(=O)N[C@H](C=O)Cc2ccccc2)=Cc2cc(Cl)c(Cl)cc2S1(=O)=O CHEMBL421043 IC50 15.0 nM
O=Cc1cccc(-c2ccc(S(=O)(=O)NCCNC(=O)C(=O)[C@H](Cc3ccccc3)NC(=O)c3c(Cl)cccc3Cl)s2)c1 CHEMBL312549 Ki 15.0 nM
O=CC(Cc1ccccc1)NC(=O)c1ccccc1/C=C/c1ccc2ccccc2c1 CHEMBL280654 Ki 15.0 nM
O=CC(Cc1ccccc1)NC(=O)c1ccccc1/C=C/c1cccc2ccccc12 CHEMBL80903 Ki 15.0 nM
CC(C)C[C@@H](C=O)NC(=O)[C@H](CC(C)C)NC(=O)C1Cc2ccccc2CN1C(=O)OCc1ccccc1 CHEMBL150256 IC50 15.0 nM
CC(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](C=O)CC(C)C CHEMBL151206 IC50 15.0 nM
CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@H](C=O)Cc1c[nH]cn1 CHEMBL424142 IC50 15.0 nM
CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)C(=O)NOCc1ccccc1 CHEMBL313895 IC50 17.0 nM
CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)C(=O)NOCc1c(F)c(F)c(F)c(F)c1F CHEMBL89771 IC50 17.0 nM
CC(C)C[C@@H](C=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)OCc1ccccc1 CHEMBL151679 IC50 17.0 nM
Cc1ccc(S(=O)(=O)N[C@H](C(=O)N[C@@H](C=O)Cc2ccccc2)C(C)C)cc1 CHEMBL169551 IC50 18.0 nM
CC(=O)N[C@@H](C)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](C=O)CC(C)C CHEMBL151468 IC50 18.0 nM
NC(=O)C(=O)C(Cc1ccccc1)NC(=O)c1cccnc1-n1ccc(-c2ccccc2)n1 CHEMBL4095528 Ki 18.0 nM
CN(C)Cc1ccc(/C=C/c2ncccc2C(=O)NC(Cc2ccccc2)C(N)=O)cc1 CHEMBL80933 Ki 18.3 nM
CCONC(=O)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1 CHEMBL301598 IC50 19.0 nM
CCCC(NC(=O)C(CC(C)C)NC(=O)OCc1ccccc1)C(=O)C(=O)NCc1ccccn1 CHEMBL132586 Ki 19.0 nM
CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](C=O)CC(C)C CHEMBL151176 IC50 19.0 nM
O=C[C@H](Cc1ccccc1)NC(=O)C(Cc1ccccc1)NS(=O)(=O)c1ccccc1 CHEMBL8703 IC50 20.0 nM
CONC(=O)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1 CHEMBL316135 IC50 20.0 nM
CC(C)C[C@H](NC(=O)c1ccc2c(c1)CCN2Cc1ccccc1)C(=O)N[C@H]1CCOC1O CHEMBL333995 IC50 20.0 nM
CCN1C(C(=O)N[C@@H](Cc2ccccc2)C(=O)C(=O)NCCNS(=O)(=O)c2ccc(-c3ccccn3)s2)Cc2cc3c(cc2S1(=O)=O)OCCO3 CHEMBL268950 IC50 20.0 nM
CC(C)C[C@H](C=O)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)OCc1ccccc1 CHEMBL151415 IC50 20.0 nM
CCCCC(NC(=O)c1cccnc1-n1cc(-c2ccccc2)cn1)C(=O)C(N)=O CHEMBL4068214 Ki 20.0 nM
COCCN/C(=C1/N=C(C)N(CCOC)C1=O)c1cc2ccccc2[nH]1 CHEMBL4277595 IC50 20.0 nM
CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)C(=O)NOC1CCC(C)CC1 CHEMBL419311 IC50 21.0 nM
CCCC[C@H](NC(=O)[C@@H](NC(=O)OCc1ccccc1)C(C)C)C(=O)C(=O)NOCc1ccccc1 CHEMBL85296 IC50 21.0 nM
O=C(NCCNS(=O)(=O)c1ccc(-c2cccc(CN3CCOCC3)c2)s1)C(=O)[C@H](Cc1ccccc1)NC(=O)c1c(Cl)cccc1Cl CHEMBL311256 Ki 21.0 nM
CC(C)CCC(=O)N[C@@H](Cc1ccccc1)C(=O)C(=O)NCCNS(=O)(=O)c1ccc(-c2ccccn2)s1 CHEMBL76145 Ki 21.0 nM
CCCCNC(=O)C(=O)[C@H](CC(C)C)NC(=O)[C@@H](NS(=O)(=O)c1ccc(F)cc1)C(C)C CHEMBL209457 IC50 21.0 nM
NC(=O)C(=O)C(Cc1ccccc1)NC(=O)c1cccnc1-n1cc(-c2ccccc2)cn1 CHEMBL4077634 Ki 21.0 nM
O=C[C@H](Cc1ccccc1)NC(=O)[C@@H](COCc1ccccc1)NS(=O)(=O)c1ccccc1 CHEMBL313712 Ki 22.0 nM
CC(C)C[C@@H](C=O)NC(=O)[C@@H](NS(=O)(=O)c1ccc(F)cc1)C(C)C CHEMBL288365 IC50 22.0 nM
CC(C)C[C@H](NC(=O)c1ccc2c(c1)Nc1ccccc1S2)C(=O)N[C@H]1CCOC1O CHEMBL3706732 IC50 22.5 nM
CC(C)[C@H](NS(=O)(=O)c1ccc(F)cc1)C(=O)N[C@@H](C=O)Cc1c[nH]c2ccccc12 CHEMBL169573 IC50 23.0 nM
CSCC[C@@H](C=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O CHEMBL318779 IC50 23.0 nM
CN1C(C(=O)N[C@H](C=O)Cc2ccccc2)Cc2cc3c(cc2S1(=O)=O)OCCO3 CHEMBL115954 IC50 24.0 nM
CC(C)C[C@H](CC(=O)C1c2ccccc2Oc2ccccc21)C(=O)N[C@H](C=O)CC(C)C CHEMBL42716 IC50 25.0 nM
CC(C)C[C@H](C=O)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)OCc1ccccc1 CHEMBL358158 IC50 25.0 nM
CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)C(=O)NOC(C)(C)C CHEMBL441262 IC50 26.0 nM
O=C(NCCNS(=O)(=O)c1ccc(-c2ccccn2)s1)C(=O)[C@H](Cc1ccccc1)NC(=O)c1c(Cl)cccc1Cl CHEMBL310826 Ki 26.0 nM
NC(=O)C(=O)C(Cc1ccccc1)NC(=O)[C@H]1CCC(=O)N1Cc1cccc(C(F)(F)F)c1 CHEMBL4462518 Ki 26.0 nM
CC(C)[C@H](NS(=O)(=O)c1ccc(F)cc1)C(=O)N[C@@H](C=O)Cc1ccccc1 CHEMBL169690 IC50 27.0 nM
CCN(CC)Cc1ccc(/C=C/c2ccccc2C(=O)NC(Cc2ccccc2)C(N)=O)cc1 CHEMBL80605 Ki 27.0 nM
Cc1ccc(S(=O)(=O)N[C@H](C(=O)N[C@@H](C=O)CC(C)C)C(C)C)cc1 CHEMBL168965 IC50 28.0 nM
CN1C(C(=O)N[C@H](C=O)Cc2ccccc2)Cc2cc(F)ccc2S1(=O)=O CHEMBL331414 IC50 28.0 nM
O=C[C@H](Cc1ccccc1)NC(=O)C1=NS(=O)(=O)c2cc3c(cc2N1)OCCO3 CHEMBL115963 IC50 28.0 nM
CN1C(C(=O)N[C@H](C=O)Cc2ccccc2)Cc2ccccc2S1(=O)=O CHEMBL420698 IC50 28.0 nM
CS(=O)(=O)N[C@H](COCc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)C(=O)NOCc1ccccc1 CHEMBL418946 IC50 28.0 nM
CS(=O)(=O)N[C@H](COCc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCc1ccccc1 CHEMBL86486 IC50 28.0 nM
CS(=O)(=O)N[C@H](CCc1ccccc1)C(=O)N[C@H](C=O)Cc1ccccc1 CHEMBL88854 Ki 28.0 nM
Cc1ccc(S(=O)(=O)N2C[C@H](C#N)C[C@H]2C(=O)N[C@H](C=O)Cc2ccccc2)cc1 CHEMBL2367774 IC50 28.0 nM
Cc1ccc(S(=O)(=O)N2C[C@H](N=[N+]=[N-])C[C@H]2C(=O)N[C@H](C=O)Cc2ccccc2)cc1 CHEMBL2367776 IC50 28.0 nM
Cc1ccc(S(=O)(=O)N2CC(N=[N+]=[N-])CC2C(=O)N[C@H](C=O)Cc2ccccc2)cc1 CHEMBL115073 IC50 28.0 nM
CC(C)C[C@@H](NS(C)(=O)=O)C(=O)N[C@H](C=O)Cc1ccccc1 CHEMBL91836 Ki 29.0 nM
CCN1C(C(=O)N[C@@H](Cc2ccccc2)C(=O)C(=O)NCCNS(=O)(=O)c2ccc(F)cc2)Cc2cc3c(cc2S1(=O)=O)OCCO3 CHEMBL8294 IC50 29.0 nM
CC(C)C[C@@H](C=O)NC(=O)[C@@H](NC(=O)OCc1ccccc1)C(C)C CHEMBL434278 IC50 29.0 nM
CC(C)N1C(C(=O)N[C@H](C=O)Cc2ccccc2)Cc2cc3c(cc2S1(=O)=O)OCCO3 CHEMBL115573 IC50 30.0 nM
CN1C(C(=O)N[C@H](C=O)Cc2ccccc2)Cc2cc(N3CCOCC3)ccc2S1(=O)=O CHEMBL117006 IC50 30.0 nM
CC(C)C[C@H](CC[S+]([O-])c1ccc2ccccc2c1)C(=O)N[C@H](C=O)CC(C)C CHEMBL98832 IC50 30.0 nM
NC(=O)C(=O)C(Cc1ccccc1)NC(=O)C1CCN(C(=O)c2ccc3ccccc3c2)CC1 CHEMBL69715 Ki 30.0 nM
CC(C)C[C@H](NC(=O)[C@H]1O[C@@H]1C(=O)O)C(=O)Nc1nc(-c2ccc(F)cc2)cs1 CHEMBL2408922 IC50 30.0 nM
CC(C)C[C@H](NC(=O)[C@H]1O[C@@H]1C(=O)O)C(=O)NCc1cn(-c2ccc(F)cc2)nn1 CHEMBL3962819 IC50 30.0 nM
CC(C)C[C@H](C=O)NC(=O)[C@@H](NS(=O)(=O)c1ccc(Cl)cc1)C(C)C CHEMBL169230 IC50 31.0 nM
CC(C)C[C@H](C=O)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)OCc1ccccc1)C(C)C CHEMBL151595 IC50 31.0 nM
CC(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](C=O)Cc1ccccc1 CHEMBL415736 IC50 32.0 nM
CCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1)C(=O)NCC CHEMBL99129 Ki 32.0 nM
CCCCC(NC(=O)c1cccnc1-n1ccc(-c2ccccc2)n1)C(=O)C(N)=O CHEMBL4094839 Ki 32.0 nM
CC(C)C(NC(=O)OCc1ccccc1)C(=O)N1CO[C@@H](O)[C@@H]1Cc1ccccc1 CHEMBL311735 Ki 33.0 nM
CCCC[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@H](C=O)CC(C)C CHEMBL150076 IC50 33.0 nM
CC(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](C=O)CCCCNC(=O)OC(C)(C)C CHEMBL356003 IC50 33.0 nM
CSCC[C@@H](C=O)NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1 CHEMBL99195 IC50 33.0 nM
NC(=O)C(=O)C(Cc1ccccc1)NC(=O)c1cccnc1-n1ccc(-c2ccc(F)cc2)n1 CHEMBL4063636 Ki 34.0 nM
CCN1C(C(=O)N[C@@H](Cc2ccccc2)C(=O)C(=O)NCCCNS(=O)(=O)c2ccccc2)Cc2cc3c(cc2S1(=O)=O)OCCO3 CHEMBL267888 IC50 35.0 nM
Cc1ccc(S(=O)(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C=O)CC(C)C)cc1 CHEMBL150380 IC50 35.0 nM
CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@H](C=O)C(C)(C)C CHEMBL151333 IC50 35.0 nM
CN1C(C(=O)N[C@H](C=O)CCCCNS(=O)(=O)c2ccccc2)Cc2cc3c(cc2S1(=O)=O)OCCO3 CHEMBL333622 IC50 36.0 nM
CC[C@@H](C=O)NC(=O)[C@@H](COCc1ccccc1)NS(C)(=O)=O CHEMBL91716 Ki 36.0 nM
CCNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1 CHEMBL316932 Ki 36.0 nM
COc1cccc(C(F)(F)F)c1CN1C(=O)CC[C@@H]1C(=O)NC(Cc1ccccc1)C(=O)C(N)=O CHEMBL4456320 Ki 36.0 nM
CCN1C(C(=O)N[C@H](C=O)CC(C)C)Cc2cc3c(cc2S1(=O)=O)OCCO3 CHEMBL115572 IC50 37.0 nM
COC1=C(C(=O)N[C@H](C=O)Cc2ccccc2)N(C)S(=O)(=O)c2ccccc21 CHEMBL117694 IC50 37.0 nM
CC(=O)N[C@@H](COC(C)(C)C)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](C=O)CC(C)C CHEMBL151115 IC50 37.0 nM
COc1cc2c(cc1OC)S(=O)(=O)N(C)C(C(=O)N[C@H](C=O)Cc1ccccc1)C2 CHEMBL332683 IC50 38.0 nM
NC(=O)C(=O)C(Cc1ccccc1)NC(=O)c1cccnc1-c1csc(-c2ccccc2)n1 CHEMBL4071319 Ki 38.0 nM
CCCCC(NC(=O)c1cccnc1-n1cnc(-c2ccccc2)c1)C(=O)C(N)=O CHEMBL4061997 Ki 38.0 nM
NC(=O)C(=O)C(Cc1ccccc1)NC(=O)c1cccnc1-n1ccc(Cc2ccccc2)n1 CHEMBL4075477 Ki 38.0 nM
NC(=O)C(=O)C(Cc1ccccc1)NC(=O)[C@H]1CCC(=O)N1Cc1ccccc1 CHEMBL4591200 Ki 39.0 nM
CC(C)CCNC(=O)[C@H](CC(C)C)NC(=O)[C@H]1O[C@@H]1C(=O)O CHEMBL418661 I50 40.0 nM
CCN1C(C(=O)N[C@@H](Cc2ccccc2)C(=O)C(=O)NCCNS(=O)(=O)c2ccccc2)Cc2cc3c(cc2S1(=O)=O)OCCO3 CHEMBL8858 IC50 40.0 nM
NC(=O)C(=O)C(Cc1ccccc1)NC(=O)c1ccccc1-c1ccccc1 CHEMBL284866 Ki 40.0 nM
COc1ccc(/C=C/c2ccccc2C(=O)NC(C=O)Cc2ccccc2)cc1OC CHEMBL282979 Ki 40.0 nM
CC(C)C[C@H](C=O)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)OCc1ccccc1 CHEMBL356838 IC50 40.0 nM
Cc1c(C(=O)N[C@@H](Cc2ccccc2)C(=O)C(N)=O)oc2ccccc2c1=O CHEMBL195728 IC50 40.0 nM
O=C(NCc1cn(-c2ccc(Br)cc2)nn1)[C@H](Cc1cscn1)NC(=O)[C@H]1O[C@@H]1C(=O)O CHEMBL2408904 IC50 40.0 nM
NC(=O)C(=O)C(Cc1ccccc1)NC(=O)c1cccnc1-n1ccc(-c2cccc(C(F)(F)F)c2)n1 CHEMBL4104445 Ki 40.0 nM
CS(=O)(=O)N[C@@H](COCc1ccccc1)C(=O)N[C@H](C=O)Cc1ccccc1 CHEMBL2114233 Ki 41.0 nM
O=C[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccccc1 CHEMBL313995 IC50 41.0 nM
CC[C@H](C)[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@H](C=O)CC(C)C CHEMBL422142 IC50 41.0 nM
NC(=O)C(=O)C(Cc1ccccc1)NC(=O)c1cccnc1-n1ccc(-c2ccc(CN3CCOCC3)cc2)n1 CHEMBL4073154 Ki 41.0 nM
NC(=O)C(=O)C(Cc1ccccc1)NC(=O)c1ccccc1-n1ccc(-c2ccccc2)n1 CHEMBL4103597 Ki 43.0 nM
CS(=O)(=O)N1CCC[C@H]1C(=O)N[C@H](C=O)Cc1ccccc1 CHEMBL310648 IC50 45.0 nM
CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C=O)CC(C)C CHEMBL151970 IC50 45.0 nM
NC(=O)C(=O)C(Cc1ccccc1)NC(=O)c1cccnc1-n1cnc(-c2ccccc2)c1 CHEMBL4087819 Ki 45.0 nM
COc1ccc(Cl)c(C(=O)N[C@@H](Cc2ccccc2)C(=O)C(=O)NCCNS(=O)(=O)c2ccc(-c3ccccn3)s2)c1 CHEMBL404598 Ki 46.0 nM
NC(=O)C(=O)C(Cc1ccccc1)NC(=O)c1cccnc1-n1cc2ccccc2n1 CHEMBL4072233 Ki 46.0 nM
CCCCC(NC(=O)[C@H]1CCC(=O)N1Cc1ccccc1)C(=O)C(N)=O CHEMBL4456885 Ki 46.0 nM
CCN1C(C(=O)N[C@@H](Cc2ccccc2)C(=O)C(=O)NCCNS(=O)(=O)c2ccc([N+](=O)[O-])cc2)Cc2cc3c(cc2S1(=O)=O)OCCO3 CHEMBL8104 IC50 47.0 nM
NC(=O)C(=O)C(Cc1ccccc1)NC(=O)c1cccnc1-n1ccc(C2CCOCC2)n1 CHEMBL4080843 Ki 48.0 nM
O=C(NCc1ccc(F)cc1)C(=O)C(Cc1ccccc1)NC(=O)[C@H]1CCC(=O)N1Cc1ccccc1 CHEMBL4454219 Ki 48.0 nM
O=C(NCCNS(=O)(=O)c1ccc(-c2ccccn2)s1)C(=O)[C@H](Cc1ccccc1)NC(=O)c1cc(Cl)ccc1Cl CHEMBL306616 Ki 49.0 nM
CC(C)C[C@H](CC(=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C=O)CC(C)C CHEMBL42617 IC50 50.0 nM
CCN1C(C(=O)N[C@@H](Cc2ccccc2)C(=O)C(=O)NCCCNS(=O)(=O)c2ccc(F)cc2)Cc2cc3c(cc2S1(=O)=O)OCCO3 CHEMBL8757 IC50 50.0 nM
CCN1C(C(=O)N[C@@H](Cc2ccccc2)C(=O)C(=O)NCCCNS(=O)(=O)c2ccc([N+](=O)[O-])cc2)Cc2cc3c(cc2S1(=O)=O)OCCO3 CHEMBL276726 IC50 50.0 nM
O=CC(Cc1ccccc1)NC(=O)c1ccccc1Oc1ccccc1 CHEMBL28203 Ki 50.0 nM
O=CC(Cc1ccccc1)NC(=O)c1ccccc1OCc1ccc2ccccc2c1 CHEMBL27036 Ki 50.0 nM
CCC(NC(=O)C(CC(C)C)NC(=O)OCc1ccccc1)C(=O)C(=O)NCC(O)c1c(F)c(F)c(F)c(F)c1F CHEMBL129831 Ki 50.0 nM
CC(C)C[C@H](CCS(=O)(=O)c1ccc2ccccc2c1)C(=O)N[C@H](C=O)CC(C)C CHEMBL100316 IC50 50.0 nM
CC(C)C[C@H](NC(=O)[C@H]1O[C@@H]1C(=O)O)C(=O)Nc1c(F)cccc1F CHEMBL2408924 IC50 50.0 nM
CC(C)C[C@H](NC(=O)[C@H]1O[C@@H]1C(=O)O)C(=O)NCc1cn(-c2ccc(S(N)(=O)=O)cc2)nn1 CHEMBL3938833 IC50 50.0 nM
C[C@H]1C[C@H](C(=O)NC(Cc2ccccc2)C(=O)C(N)=O)N(Cc2ccccc2)C1=O CHEMBL4546164 Ki 50.0 nM
O=C(NC1CC1)C(=O)C(Cc1ccccc1)NC(=O)[C@H]1CCC(=O)N1Cc1ccccc1OC(F)(F)F CHEMBL4541818 Ki 50.0 nM
COc1cc2c(cc1OC)S(=O)(=O)OC(C(=O)N[C@H](C=O)Cc1ccccc1)C2 CHEMBL331649 IC50 51.0 nM
CC(C)CC(NC(=O)OCc1ccccc1)C(=O)NC(Cc1ccccc1)C(=O)C(=O)NCCc1ccccc1 CHEMBL331850 Ki 52.0 nM
CS(=O)(=O)N1CCC[C@@H]1C(=O)N[C@H](C=O)Cc1ccccc1 CHEMBL88359 IC50 53.0 nM
CCONC(=O)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](COCc1ccccc1)NS(C)(=O)=O CHEMBL314039 IC50 56.0 nM
CCNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](COCc1ccccc1)NS(C)(=O)=O CHEMBL89693 IC50 56.0 nM
CCN1C(C(=O)N[C@@H](Cc2ccccc2)C(=O)C(=O)NCCNS(=O)(=O)c2ccc(Cl)c(Cl)c2)Cc2cc3c(cc2S1(=O)=O)OCCO3 CHEMBL8641 IC50 56.0 nM
CCN1C(C(=O)N[C@@H](Cc2ccccc2)C(=O)C(=O)NCCCNS(=O)(=O)c2ccc(Cl)c(Cl)c2)Cc2cc3c(cc2S1(=O)=O)OCCO3 CHEMBL8391 IC50 56.0 nM
CCN(CC)Cc1ccc(/C=C/c2ccccc2C(=O)NC(Cc2ccccc2)C(=O)C(N)=O)cc1 CHEMBL4066494 Ki 56.0 nM
NC(=O)C(=O)C(Cc1ccccc1)NC(=O)c1cccnc1-n1ccc(C2CCCCC2)n1 CHEMBL4073616 Ki 56.0 nM
CCN(CC)c1ccc(/C=C/c2ccccc2C(=O)NC(Cc2ccccc2)C(=O)C(N)=O)cc1 CHEMBL5195850 Ki 56.0 nM
O=C(Cc1ccc(Cl)nc1Cl)N[C@@H](Cc1ccccc1)C(=O)C(=O)NCCNS(=O)(=O)c1ccc(-c2ccccn2)s1 CHEMBL80592 Ki 57.0 nM
NC(=O)C(=O)C(Cc1ccccc1)NC(=O)[C@H]1CCC(=O)N1Cc1ccccc1OC(F)(F)F CHEMBL4518359 Ki 57.0 nM
O=C(NCCNS(=O)(=O)c1ccc(CN2CCN(c3ccccn3)CC2)cc1)C(=O)[C@H](Cc1ccccc1)NC(=O)c1c(Cl)cccc1Cl CHEMBL311714 Ki 59.0 nM
NC(=O)C(=O)C(Cc1ccccc1)NC(=O)[C@H]1CCC(=O)N1Cc1ccccc1C(F)(F)F CHEMBL4440356 Ki 59.0 nM
CCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)NCC CHEMBL101791 Ki 61.0 nM
CC(CCC(=O)N[C@@H](Cc1ccccc1)C(=O)C(=O)NCCNS(=O)(=O)c1ccc(-c2ccccn2)s1)c1ccccc1 CHEMBL76798 Ki 62.0 nM
CC(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](C=O)CC(C)C CHEMBL357503 IC50 62.0 nM
CCN1C(C(=O)N[C@@H](Cc2ccccc2)C(=O)C(=O)NCCc2ccccc2)Cc2cc3c(cc2S1(=O)=O)OCCO3 CHEMBL268737 IC50 63.0 nM
NC(=O)C(=O)C(Cc1ccccc1)NC(=O)[C@H]1CCCC(=O)N1Cc1ccccc1 CHEMBL4578614 Ki 64.0 nM
CC(C)C[C@@H](C=O)NC(=O)[C@@H](COCc1ccccc1)NS(C)(=O)=O CHEMBL91316 Ki 66.0 nM
CCCC(NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1)C(=O)NCC CHEMBL419898 Ki 66.0 nM
CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](C=O)CC(C)C CHEMBL150620 IC50 68.0 nM
CCC(NC(=O)C(CC(C)C)NC(=O)OCc1ccccc1)C(=O)C(=O)NCC(O)c1cccc(Oc2cccc(C(F)(F)F)c2)c1 CHEMBL134092 Ki 70.0 nM
O=C(Nc1ccccc1)C(=O)C(Cc1ccccc1)NC(=O)[C@H]1CCC(=O)N1Cc1ccccc1 CHEMBL4590202 Ki 70.0 nM
CC(=O)N1CCN(Cc2ccc(S(=O)(=O)NCCNC(=O)C(=O)[C@H](Cc3ccccc3)NC(=O)c3c(Cl)cccc3Cl)cc2)CC1 CHEMBL309639 Ki 71.0 nM
CC(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](C=O)CCCN=C(N)N CHEMBL433692 IC50 72.0 nM
NC(=O)C(=O)C(Cc1ccccc1)NC(=O)c1cccnc1-n1ccc(-c2ccc(C(F)(F)F)cc2)n1 CHEMBL4080204 Ki 72.0 nM
O=C(NC1CC1)C(=O)C(Cc1ccccc1)NC(=O)[C@H]1CCC(=O)N1Cc1ccccc1Cl CHEMBL4465930 Ki 73.0 nM
CCNC(=O)C(Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1 CHEMBL98777 Ki 74.0 nM
CC(C)C[C@H](CCSc1ccc2ccccc2c1)C(=O)N[C@H](C=O)CC(C)C CHEMBL439590 IC50 75.0 nM
CCCONC(=O)C(=O)C(Cc1ccccc1)NC(=O)c1cccnc1-n1ccc(-c2ccccc2)n1 CHEMBL4290071 Ki 75.0 nM
O=C(NCCNS(=O)(=O)c1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)C1Cc2cc3c(cc2S(=O)(=O)N1)OCCO3 CHEMBL8686 IC50 76.0 nM
CCNC(=O)CCCNC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1 CHEMBL330186 Ki 77.0 nM
COc1ccc(/C=C/c2ccccc2C(=O)NC(Cc2ccccc2)C(=O)C(N)=O)cc1OC CHEMBL441599 Ki 80.0 nM
CCC(NC(=O)C(CC(C)C)NC(=O)OCc1ccccc1)C(=O)C(=O)NCC(O)c1ccc(OCc2ccccc2)cc1 CHEMBL133521 Ki 80.0 nM
CCN1C(C(=O)N[C@@H](Cc2ccccc2)C(=O)C(=O)NCc2ccccc2)Cc2cc3c(cc2S1(=O)=O)OCCO3 CHEMBL8459 IC50 81.0 nM
CC(C)(C)c1ccn(-c2ncccc2C(=O)NC(Cc2ccccc2)C(=O)C(N)=O)n1 CHEMBL4094243 Ki 81.0 nM
CC(C)C[C@H](NC(=O)c1cccc2c1Nc1ccccc1S2)C(=O)N[C@H]1CCOC1O CHEMBL3706727 IC50 82.0 nM
NC(=O)C(=O)C(Cc1ccccc1)NC(=O)c1ccccc1-c1csc(-c2ccccc2)n1 CHEMBL4073071 Ki 82.0 nM
NC(=O)C(=O)C(Cc1ccccc1)NC(=O)c1cccc(=O)n1Cc1ccccc1 CHEMBL4593652 Ki 82.0 nM
O=C[C@H](Cc1ccccc1)NC(=O)C1=NS(=O)(=O)c2ccccc2N1 CHEMBL118817 IC50 83.0 nM
COc1ccc(-c2ccn(-c3ncccc3C(=O)NC(Cc3ccccc3)C(=O)C(N)=O)n2)cc1 CHEMBL4075889 Ki 83.0 nM
CN1C(=O)c2ccccc2CC1C(=O)N[C@H](C=O)Cc1ccccc1 CHEMBL326758 IC50 85.0 nM
CC(C)C[C@H](NC(=S)Nc1ccccc1)C(=O)N[C@H]1CCOC1O CHEMBL207440 IC50 86.0 nM
NC(=O)C(=O)C(Cc1ccccc1)NC(=O)c1cccnc1-n1ccc(-c2ccc(Cl)cc2)n1 CHEMBL4067197 Ki 88.0 nM
CCN1C(C(=O)N[C@@H](Cc2ccccc2)C(=O)C(=O)NCCNS(C)(=O)=O)Cc2cc3c(cc2S1(=O)=O)OCCO3 CHEMBL418150 IC50 89.0 nM
O=CC(Cc1ccccc1)NC(=O)c1ccccc1-c1ccccc1 CHEMBL283475 Ki 90.0 nM
CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@H](C)C(=O)N[C@@H](C=O)CC(C)C CHEMBL357787 IC50 90.0 nM
O=C(NOCC1CC1)C(=O)C(Cc1ccccc1)NC(=O)c1cccnc1-n1ccc(-c2ccccc2)n1 CHEMBL4285615 Ki 90.0 nM
O=C(NC1CC1)C(=O)C(Cc1ccccc1)NC(=O)[C@H]1CCC(=O)N1Cc1ccccc1C(F)(F)F CHEMBL4588337 Ki 90.0 nM
COC(=O)[C@H](C)NC(=O)C(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1 CHEMBL321936 Ki 92.0 nM
CCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)NCC CHEMBL327974 Ki 93.0 nM
NC(=O)C(=O)C(Cc1ccccc1)NC(=O)c1cccnc1-n1ccc(C2CC2)n1 CHEMBL4104332 Ki 94.0 nM
Cc1ccc(S(=O)(=O)N2C[C@H](NC(=O)C(F)(F)F)C[C@H]2C(=O)N[C@H](C=O)Cc2ccccc2)cc1 CHEMBL2367773 IC50 100.0 nM
CCC(NC(=O)C(CC(C)C)NC(=O)OCc1ccccc1)C(=O)C(=O)NCC(O)c1ccc(Oc2ccccc2)cc1 CHEMBL131002 Ki 100.0 nM
O=C(NCc1cn(-c2ccc(F)cc2)nn1)[C@H](Cc1cscn1)NC(=O)[C@H]1O[C@@H]1C(=O)O CHEMBL2408899 IC50 100.0 nM
C#Cc1ccc(-c2csc(NC(=O)[C@H](Cc3cscn3)NC(=O)[C@H]3O[C@@H]3C(=O)O)n2)cc1 CHEMBL2408918 IC50 100.0 nM
O=C(Nc1nc(-c2ccc(F)cc2)cs1)[C@H](Cc1cscn1)NC(=O)[C@H]1O[C@@H]1C(=O)O CHEMBL2408917 IC50 100.0 nM
O=C(Nc1nc(-c2ccc(F)cc2)cs1)C(Cc1cnc[nH]1)NC(=O)[C@H]1O[C@@H]1C(=O)O CHEMBL2408912 IC50 100.0 nM
CC(C)C[C@H](NC(=O)[C@H]1O[C@@H]1C(=O)O)C(=O)NCCCCNC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@@H]21 CHEMBL2408909 IC50 100.0 nM
CC(C)C[C@H](NC(=O)[C@H]1O[C@@H]1C(=O)O)C(=O)NCCCCNC(=O)CCCCC1CCSS1 CHEMBL2408908 IC50 100.0 nM
CC(C)C[C@H](NC(=O)[C@H]1O[C@@H]1C(=O)O)C(=O)Nc1ccccc1 CHEMBL2408919 IC50 100.0 nM
CC(C)C[C@H](NC(=O)[C@H]1O[C@@H]1C(=O)O)C(=O)NCCCCN=C(N)N CHEMBL374508 IC50 100.0 nM
CC(C)C[C@H](NC(=O)C1O[C@@H]1C(=O)O)C(=O)NCCCCNC(=N)N CHEMBL3901496 IC50 100.0 nM
CC(C)C[C@H](NC(=O)C1O[C@@H]1C(=O)O)C(=O)NCCCCNS(=O)(=O)c1ccc(F)cc1 CHEMBL3906209 IC50 100.0 nM
CC(C)C[C@H](NC(=O)[C@H]1O[C@@H]1C(=O)O)C(=O)NCCCCNS(=O)(=O)c1ccc(F)cc1 CHEMBL2408921 IC50 100.0 nM
O=C(Nc1nc(-c2ccc(F)cc2)cs1)[C@H](Cc1cscn1)NC(=O)[C@@H]1O[C@H]1C(=O)O CHEMBL3960800 IC50 100.0 nM
CC(C)C[C@H](NC(=O)C1O[C@@H]1C(=O)O)C(=O)NCCCCNC(=O)CCCCC1CCSS1 CHEMBL3938487 IC50 100.0 nM
CC(C)C[C@H](NC(=O)C1O[C@@H]1C(=O)O)C(=O)NCCCCNC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@@H]21 CHEMBL3934516 IC50 100.0 nM
CCN(CC)Cc1ccc(-c2ccn(-c3ncccc3C(=O)NC(Cc3ccccc3)C(=O)C(N)=O)n2)cc1 CHEMBL4094544 Ki 100.0 nM
NC(=O)C(=O)C(Cc1ccccc1)NC(=O)c1cccnc1-n1cc2c(n1)CCCC2 CHEMBL4095627 Ki 101.0 nM
CN1C[C@H](C(=O)NC(Cc2ccccc2)C(=O)C(N)=O)N(Cc2ccccc2)C1=O CHEMBL4476684 Ki 101.0 nM
CCN(CC)Cc1ccc(/C=C/c2ncccc2C(=O)NC(Cc2ccccc2)C(=O)C(N)=O)cc1 CHEMBL4076893 Ki 109.0 nM
CC(C)CC(NC(=O)OCc1ccccc1)C(=O)NC(Cc1ccccc1)C(=O)C(=O)NCc1ccc2ccccc2n1 CHEMBL134283 Ki 110.0 nM
CCC(NC(=O)C(CC(C)C)NC(=O)OCc1ccccc1)C(=O)C(=O)NCCc1cccc(OC)c1 CHEMBL130338 Ki 110.0 nM
CC(=O)N[C@H](C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](C=O)CC(C)C)C(C)C CHEMBL150136 IC50 110.0 nM
COCCOC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)C(=O)NC1CC1 CHEMBL478222 IC50 110.0 nM
CCONC(=O)C(=O)C(Cc1ccccc1)NC(=O)c1cccnc1-n1ccc(-c2ccccc2)n1 CHEMBL4278724 Ki 110.0 nM
O=C(NCc1ccccc1)C(=O)C(Cc1ccccc1)NC(=O)c1cccnc1-n1ccc(-c2ccccc2)n1 CHEMBL4290469 Ki 110.0 nM
O=C(NC1CCC1)C(=O)C(Cc1ccccc1)NC(=O)[C@H]1CCC(=O)N1Cc1ccccc1 CHEMBL4441800 Ki 110.0 nM
CCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)Cc1ccccc1)C(=O)NCC CHEMBL101954 Ki 116.0 nM
CCNC(=O)CCCNC(=O)[C@H](CC(C)C)NC(=O)N1CCOCC1 CHEMBL98950 Ki 119.0 nM
COC(=O)CC(NC(=O)[C@@H](NC(=O)OCc1ccccc1)C(C)C)C(=O)CF CHEMBL23453 IC50 120.0 nM
CCC(NC(=O)C(CC(C)C)NC(=O)OCc1ccccc1)C(=O)C(=O)NCC(O)c1cccc2ccccc12 CHEMBL132987 Ki 120.0 nM
CCC(NC(=O)C(CC(C)C)NC(=O)OCc1ccccc1)C(=O)C(=O)NCCc1ccc(OC)cc1 CHEMBL134173 Ki 120.0 nM
CC(C)CC(NC(=O)OCc1ccccc1)C(=O)NC(Cc1ccccc1)C(=O)C(=O)NCCCN1CCOCC1 CHEMBL335291 Ki 120.0 nM
CC(C)C[C@@H](C=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1 CHEMBL150774 IC50 120.0 nM
CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](C)C=O CHEMBL151527 IC50 120.0 nM
O=C(NOC1CCCC1)C(=O)C(Cc1ccccc1)NC(=O)c1cccnc1-n1ccc(-c2ccccc2)n1 CHEMBL4292263 Ki 120.0 nM
CONC(=O)C(=O)C(Cc1ccccc1)NC(=O)c1cccnc1-n1ccc(-c2ccccc2)n1 CHEMBL4286633 Ki 120.0 nM
CCCCC(NC(=O)c1cccnc1-c1csc(-c2ccccc2)n1)C(=O)C(N)=O CHEMBL4073064 Ki 122.0 nM
O=C[C@H](Cc1ccccc1)NC(=O)[C@@H]1C[C@@H](OCc2ccccc2)CN1S(=O)(=O)c1ccccc1 CHEMBL327448 IC50 125.0 nM
NC(=O)C(=O)C(Cc1ccccc1)NC(=O)c1cccnc1N1CCC(c2ccccc2)C1 CHEMBL4081631 Ki 125.0 nM
NC(=O)C(=O)C(Cc1ccccc1)NC(=O)[C@H]1CCC(=O)N1Cc1cccc(OC(F)(F)F)c1 CHEMBL4592411 Ki 125.0 nM
CCS(=O)(=O)CCNC(=O)C(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1 CHEMBL330417 Ki 129.0 nM
Cc1ccc(S(=O)(=O)N2CCC[C@@H]2C(=O)NC(Cc2ccccc2)C(=O)C(N)=O)cc1 CHEMBL4584187 Ki 129.0 nM
CC(C)C[C@H](NS(=O)(=O)c1ccc(F)cc1)C(=O)N[C@@H](C=O)CC(C)C CHEMBL169103 IC50 130.0 nM
COc1cc2c(cc1OC)S(=O)(=O)OC(C(=O)N[C@H](C=O)CC(C)C)C2 CHEMBL331733 IC50 130.0 nM
CCNC(=O)C(CC(C)C)NC(=O)[C@@H](CC(=O)C1c2ccccc2Oc2ccccc21)CC(C)C CHEMBL41337 IC50 130.0 nM
CCNC(=O)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](COCc1ccccc1)NS(C)(=O)=O CHEMBL80553 Ki 130.0 nM
Cc1cccc(C)c1C(=O)N[C@@H](Cc1ccccc1)C(=O)C(=O)NCCNS(=O)(=O)c1ccc(-c2ccccn2)s1 CHEMBL76036 Ki 130.0 nM
CCC(NC(=O)C(CC(C)C)NC(=O)OCc1ccccc1)C(=O)C(=O)NCc1ccc2ccccc2n1 CHEMBL133970 Ki 130.0 nM
CCC(NC(=O)C(CC(C)C)NC(=O)OCc1ccccc1)C(=O)C(=O)NCCc1ccccc1OC CHEMBL130756 Ki 130.0 nM
CC(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C=O)CC(C)C CHEMBL348197 IC50 130.0 nM
CCC/C(=C\c1ccc(O)c(O)c1)C(=O)N[C@@H](Cc1ccccc1)C(=O)C(=O)NCCc1ccc(OC)cc1 CHEMBL1770882 IC50 130.0 nM
O=C(NC1CC1)C(=O)C(Cc1ccccc1)NC(=O)[C@H]1CCC(=O)N1Cc1ccccc1 CHEMBL4463517 Ki 130.0 nM
CC(C)C[C@H](CC(=O)CCCCc1ccccc1)C(=O)N[C@H](C=O)CC(C)C CHEMBL41336 IC50 138.0 nM
O=CC(Cc1ccccc1)NC(=O)c1ccccc1/C=C/c1ccccc1 CHEMBL26631 Ki 140.0 nM
CCC(NC(=O)C(CC(C)C)NC(=O)OCc1ccccc1)C(=O)C(=O)NCCCN1CCOCC1 CHEMBL134002 Ki 140.0 nM
CC(C)C[C@@H](C=O)NC(=O)[C@H](CC(C)(C)C)NC(=O)OCc1ccccc1 CHEMBL345543 IC50 140.0 nM
CC(C)C[C@H](NC(=S)Nc1ccc(C#N)cc1)C(=O)N[C@H]1CCOC1O CHEMBL210347 IC50 140.0 nM
CN1CCC(c2ccn(-c3ncccc3C(=O)NC(Cc3ccccc3)C(=O)C(N)=O)n2)CC1 CHEMBL4097587 Ki 146.0 nM
Cc1c(C)c2c(c(C)c1O)CCC(C)(C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CCOC1O)O2 CHEMBL123621 IC50 147.0 nM
COc1cc2c(cc1OC)S(=O)(=O)N(Cc1ccccc1)C(C(=O)N[C@H](C=O)Cc1ccccc1)C2 CHEMBL332638 IC50 150.0 nM
CCCCCNC(=O)C(=O)[C@H](Cc1ccccc1)NC(=O)C1Cc2cc3c(cc2S(=O)(=O)N1CC)OCCO3 CHEMBL8741 IC50 150.0 nM
CC(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](C=O)Cc1c[nH]c2ccccc12 CHEMBL150366 IC50 150.0 nM
CC(C)C[C@H](NC(=S)Nc1ccc(F)cc1)C(=O)N[C@H]1CCOC1O CHEMBL211200 IC50 150.0 nM
CC(C)C[C@H](NC(=S)NCc1ccccc1)C(=O)N[C@H]1CCOC1O CHEMBL379402 IC50 150.0 nM
O=C(NOC1CCC1)C(=O)C(Cc1ccccc1)NC(=O)c1cccnc1-n1ccc(-c2ccccc2)n1 CHEMBL4284362 Ki 150.0 nM
COC[C@H](NC(=O)[C@@H](COCc1ccccc1)NS(C)(=O)=O)C(=O)C(=O)NOCc1ccccc1 CHEMBL87454 IC50 152.0 nM
CCCCNC(=O)C(=O)[C@H](Cc1ccccc1)NC(=O)C1=Cc2cc3c(cc2S(=O)(=O)N1CC)OCCO3 CHEMBL269383 IC50 155.0 nM
CCC(NC(=O)C(CC(C)C)NC(=O)OCc1ccccc1)C(=O)C(=O)NCCc1cccn1C CHEMBL132773 Ki 160.0 nM
NC(=O)C(=O)C(Cc1ccccc1)NC(=O)C1CCN(C(=O)c2ccc3ncccc3c2)CC1 CHEMBL73171 Ki 160.0 nM
NC(=O)C(=O)C(Cc1ccccc1)NC(=O)c1cccnc1-n1cccn1 CHEMBL4099200 Ki 164.0 nM
CCNC(=O)C(=O)C(Cc1ccccc1)NC(=O)[C@H]1CCC(=O)N1Cc1ccccc1 CHEMBL4549162 Ki 165.0 nM
CCN1C(C(=O)N[C@@H](Cc2ccccc2)C(=O)C(=O)NCc2ccccn2)Cc2cc3c(cc2S1(=O)=O)OCCO3 CHEMBL8621 IC50 170.0 nM
CCNC(=O)CCCNC(=O)[C@H](CC(C)C)NC(=O)OC(C)(C)C CHEMBL100395 Ki 170.0 nM
COCCOCCOC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)C(=O)NC1CC1 CHEMBL475920 IC50 170.0 nM
CC(C)C[C@H](NC(=O)[C@@H]1O[C@H]1C(=O)O)C(=O)Nc1nc(-c2ccc(F)cc2)cs1 CHEMBL2408920 IC50 175.0 nM
NC(=O)C(=O)C(Cc1ccccc1)NC(=O)c1cccnc1-c1coc(-c2ccccc2)n1 CHEMBL4092115 Ki 177.0 nM
CC(C)CC(NC(=O)OCc1ccccc1)C(=O)NC(Cc1ccccc1)C(=O)C(=O)NCC(O)c1cccc(Oc2cccc(C(F)(F)F)c2)c1 CHEMBL413308 Ki 180.0 nM
Cc1cccc(NC(=S)N[C@@H](CC(C)C)C(=O)N[C@H]2CCOC2O)c1 CHEMBL261953 IC50 180.0 nM
NC(=O)C(=O)C(Cc1ccccc1)NC(=O)[C@H]1CCC(=O)N1Cc1ccncc1 CHEMBL4578998 Ki 180.0 nM
C=CCONC(=O)C(=O)C(Cc1ccccc1)NC(=O)c1cccnc1-n1ccc(-c2ccccc2)n1 CHEMBL4293456 Ki 185.0 nM
CC(C)C[C@@H](C=O)NC(=O)[C@@H](NC(=O)OCc1ccccc1)[C@H](C)O CHEMBL150299 IC50 190.0 nM
COCCOCCOCCOC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)C(=O)NC1CC1 CHEMBL516123 IC50 190.0 nM
CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)c1ccccc1)C(=O)C(=O)NOCC CHEMBL315578 IC50 193.0 nM
CCN1C(C(=O)N[C@@H](Cc2ccccc2)C(=O)C(=O)NCCCN2CCOCC2)Cc2cc3c(cc2S1(=O)=O)OCCO3 CHEMBL8728 IC50 195.0 nM
CC(C)CN1C(C(=O)N[C@H](C=O)Cc2ccccc2)Cc2cc(Cl)ccc2S1(=O)=O CHEMBL117729 IC50 200.0 nM
C=CCNC(=O)C(=O)[C@H](Cc1ccccc1)NC(=O)C1Cc2cc3c(cc2S(=O)(=O)N1CC)OCCO3 CHEMBL8733 IC50 200.0 nM
CCN1C(C(=O)N[C@@H](Cc2ccccc2)C(=O)C(=O)NCCOC)Cc2cc3c(cc2S1(=O)=O)OCCO3 CHEMBL436925 IC50 200.0 nM
O=CC(Cc1ccccc1)NC(=O)c1ccccc1Cc1ccc2ccccc2c1 CHEMBL281731 Ki 200.0 nM
CCC(NC(=O)C(CC(C)C)NC(=O)OCc1ccccc1)C(=O)C(=O)NCc1ccccc1 CHEMBL118025 Ki 200.0 nM
CCOC(CNC(=O)C(=O)C(CC)NC(=O)C(CC(C)C)NC(=O)OCc1ccccc1)OCC CHEMBL130345 Ki 200.0 nM
CCC(NC(=O)C(CC(C)C)NC(=O)OCc1ccccc1)C(=O)C(=O)NCCc1ccccc1 CHEMBL117336 Ki 200.0 nM
CC(C)CC(NC(=O)OCc1ccccc1)C(=O)NC(Cc1ccccc1)C(=O)C(=O)NCC(O)c1ccc(Oc2ccccc2)cc1 CHEMBL133936 Ki 200.0 nM
CCNC(=O)C(=O)C(Cc1ccccc1)NC(=O)C(CC(C)C)NC(=O)OCc1ccccc1 CHEMBL420872 Ki 200.0 nM
CC(C)CC(NC(=O)OCc1ccccc1)C(=O)NC(Cc1ccccc1)C(=O)C(=O)NCC(O)c1ccc(OCc2ccccc2)cc1 CHEMBL337830 Ki 200.0 nM
CC(C)C[C@H](NC(=O)[C@H]1O[C@@H]1C(=O)O)C(=O)N(C)c1nc(-c2ccc(F)cc2)cs1 CHEMBL3900802 IC50 200.0 nM
NC(=O)C(=O)C(Cc1ccccc1)NC(=O)[C@H]1CCC(=O)N1CC1CCCCC1 CHEMBL4436696 Ki 200.0 nM
CCN1C(C(=O)N[C@@H](Cc2ccccc2)C(=O)C(=O)NC(C)C)Cc2cc3c(cc2S1(=O)=O)OCCO3 CHEMBL266807 IC50 205.0 nM
O=C(NC1CC1)C(=O)C(Cc1ccccc1)NC(=O)c1cccnc1-n1ccc(-c2ccccc2)n1 CHEMBL4277000 Ki 205.0 nM
O=C(O)/C(S)=C/c1ccc(I)cc1 CHEMBL366254 Ki 210.0 nM
O=C(NCc1nc2ccccc2o1)C(=O)C(Cc1ccccc1)NC(=O)c1cccnc1-n1ccc(-c2ccccc2)n1 CHEMBL4293870 Ki 210.0 nM
CC(C)CC(NC(=O)OCc1ccccc1)C(=O)NC(Cc1ccccc1)C(=O)C(=O)NCCNC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@@H]21 CHEMBL132566 Ki 220.0 nM
CC(C)CC(NC(=O)OCc1ccccc1)C(=O)NC(Cc1ccccc1)C(=O)C(=O)NCCCN1CCc2ccccc2C1 CHEMBL3706737 Ki 220.0 nM
COc1ccc(NC(=S)N[C@@H](CC(C)C)C(=O)N[C@H]2CCOC2O)cc1 CHEMBL378465 IC50 220.0 nM
COCCOCCOCCOCCOC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)C(=O)NC1CC1 CHEMBL473251 IC50 220.0 nM
CC(C)ONC(=O)C(=O)C(Cc1ccccc1)NC(=O)c1cccnc1-n1ccc(-c2ccccc2)n1 CHEMBL4282193 Ki 220.0 nM
Cc1nc[nH]c1C[C@H](NC(=O)[C@H]1O[C@@H]1C(=O)O)C(=O)Nc1nc(-c2ccc(F)cc2)cs1 CHEMBL2408897 IC50 225.0 nM
Cn1cnc(C[C@H](NC(=O)[C@H]2O[C@@H]2C(=O)O)C(=O)Nc2nc(-c3ccc(F)cc3)cs2)c1 CHEMBL3921574 IC50 225.0 nM
O=CC(Cc1ccccc1)NC(=O)c1ccccc1C(=O)c1ccccc1 CHEMBL28444 Ki 230.0 nM
CCC(NC(=O)C(CC(C)C)NC(=O)OCc1ccccc1)C(=O)C(=O)NCC(O)c1ccc(OCc2ccccc2)c(OCc2ccccc2)c1 CHEMBL130146 Ki 230.0 nM
CC(C)C[C@@H](C=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 CHEMBL149792 IC50 230.0 nM
NC(=O)C(=O)C(Cc1ccccc1)NC(=O)c1cccnc1-c1nc(-c2ccccc2)cs1 CHEMBL4080054 Ki 234.0 nM
CCNC(=O)C(=O)C(CC)NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1 CHEMBL296285 IC50 240.0 nM
CCN1C(C(=O)N[C@@H](Cc2ccccc2)C(=O)C(=O)NCc2ccncc2)Cc2cc3c(cc2S1(=O)=O)OCCO3 CHEMBL262694 IC50 240.0 nM
CCC(NC(=O)C(CC(C)C)NC(=O)OCc1ccccc1)C(=O)C(=O)NCC(O)c1ccc(OC)cc1 CHEMBL130599 Ki 240.0 nM
Cc1ccccc1NC(=S)N[C@@H](CC(C)C)C(=O)N[C@H]1CCOC1O CHEMBL209286 IC50 240.0 nM
O=C(NC1CC1)C(=O)C(Cc1ccccc1)NC(=O)[C@H]1CCC(=O)N1Cc1c(OC(F)(F)F)cccc1C(F)(F)F CHEMBL4448533 Ki 240.0 nM
CCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](N)Cc1ccccc1)C(=O)NCC CHEMBL101953 Ki 244.0 nM
CCCC(NC(=O)C(CC(C)C)NC(=O)OCc1ccccc1)C(=O)C(=O)NCCCN1CCOCC1 CHEMBL336649 Ki 250.0 nM
CCC(NC(=O)C(CC(C)C)NC(=O)OCc1ccccc1)C(=O)C(=O)NCc1nccc2ccccc12 CHEMBL422260 Ki 250.0 nM
CCNC(=O)C(=O)C(CC)NC(=O)C(CC(C)C)NC(=O)OCc1ccccc1 CHEMBL325147 Ki 250.0 nM
NC(=O)C(=O)C(Cc1ccccc1)NC(=O)c1cccnc1N1CCN(c2ccccc2)CC1 CHEMBL4075405 Ki 250.0 nM
CC(C)CC[C@H](NS(=O)(=O)c1ccc(F)cc1)C(=O)N[C@@H](C=O)CC(C)C CHEMBL433914 IC50 260.0 nM
CC(C)C[C@H](NC(=S)Nc1cccc(C#N)c1)C(=O)N[C@H]1CCOC1O CHEMBL209274 IC50 260.0 nM
O=C(O)/C(S)=C/c1c[nH]c2ccc(F)cc12 CHEMBL3221936 Ki 260.0 nM
O=C(NOCCN1CCOCC1)C(=O)C(Cc1ccccc1)NC(=O)c1cccnc1-n1ccc(-c2ccccc2)n1 CHEMBL4288855 Ki 265.0 nM
NC(=O)C(=O)C(Cc1ccccc1)NC(=O)C1CCS(=O)(=O)N1Cc1ccccc1 CHEMBL4469079 Ki 268.0 nM
CCC(NC(=O)C(CC(C)C)NC(=O)OCc1ccccc1)C(=O)C(=O)NCC(O)c1cccc(Oc2ccc(Cl)c(Cl)c2)c1 CHEMBL131639 Ki 270.0 nM
C#CCNC(=O)[C@H](CC(C)C)NC(=O)[C@H]1O[C@@H]1C(=O)O CHEMBL3919703 IC50 275.0 nM
CC(=O)c1c(Nc2ccc(Br)cc2Br)[nH]c2c(Cl)ccc(C)c2c1=O CHEMBL523822 IC50 277.0 nM
O=CC(Cc1ccccc1)NC(=O)c1ccccc1CCc1ccccc1 CHEMBL26870 Ki 280.0 nM
CCC(NC(=O)C(CC(C)C)NC(=O)OCc1ccccc1)C(=O)C(=O)NC CHEMBL131866 Ki 280.0 nM
CCN1C(C(=O)N[C@@H](Cc2ccccc2)C(=O)C(=O)NCC2CC2)Cc2cc3c(cc2S1(=O)=O)OCCO3 CHEMBL8535 IC50 286.0 nM
CCC(NC(=O)C(CC(C)C)NC(=O)OCc1ccccc1)C(=O)C(=O)NCCCn1ccnc1 CHEMBL133634 Ki 290.0 nM
CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C=O)CCCNC(=N)N CHEMBL191881 IC50 300.0 nM
CC(C)CCNC(=O)[C@H](CC(C)C)NC(=O)[C@H]1O[C@@H]1C(=O)OCCCl CHEMBL302897 I50 300.0 nM
CCNC(=O)C(=O)C(CC)NC(=O)C(CC(C)C)NC(=O)Cc1cccc2ccccc12 CHEMBL130215 Ki 300.0 nM
CCC(NC(=O)C(CC(C)C)NC(=O)OCc1ccccc1)C(=O)C(=O)NCCc1c[nH]c2ccccc12 CHEMBL131540 Ki 300.0 nM
CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)NCC=O CHEMBL151827 IC50 300.0 nM
O=C(NCc1cn(-c2ccc([N+](=O)[O-])cc2)nn1)[C@H](Cc1cscn1)NC(=O)[C@H]1O[C@@H]1C(=O)O CHEMBL2408905 IC50 300.0 nM
CCC(NC(=O)C(CC(C)C)NC(=O)OCc1ccccc1)C(=O)C(=O)NCCCN1CCc2ccccc2C1 CHEMBL3706738 Ki 310.0 nM
CC(C)C/C(=C\c1ccc(O)c(O)c1)C(=O)N[C@@H](Cc1ccccc1)C(=O)C(=O)NCc1ccccc1 CHEMBL1771025 IC50 320.0 nM
CCC(NC(=O)C(CC(C)C)NC(=O)OCc1ccccc1)C(=O)C(=O)NCC(O)c1ccc(N(C)C)cc1 CHEMBL130122 Ki 330.0 nM
CCC(NC(=O)C(CC(C)C)NC(=O)OCc1ccccc1)C(=O)C(=O)NCC1CCCO1 CHEMBL131319 Ki 330.0 nM
O=C(NCCc1ccccc1)C(=O)C(Cc1ccccc1)NC(=O)c1cccnc1-n1ccc(-c2ccccc2)n1 CHEMBL4283277 Ki 330.0 nM
CCNC(=O)CCCNC(=O)[C@H](CC(C)C)NC(=O)N(C)C CHEMBL327501 Ki 333.0 nM
CCNC(=O)C(=O)[C@H](Cc1ccccc1)NC(=O)C1Cc2cc3c(cc2S(=O)(=O)N1CC)OCCO3 CHEMBL8673 IC50 340.0 nM
COCOc1ccccc1C(=O)CCC(=O)N[C@@H](Cc1ccccc1)C(=O)C(N)=O CHEMBL458859 IC50 340.0 nM
CC(C)CC(NC(=O)OCc1ccccc1)C(=O)N[C@H](CC(C)C)C(=O)P(=O)(c1ccc(Cl)cc1)c1ccc(Cl)cc1 CHEMBL338041 IC50 350.0 nM
CCCNC(=O)C(=O)C(Cc1ccccc1)NC(=O)C(CC(C)C)NC(=O)OCc1ccccc1 CHEMBL116477 Ki 350.0 nM
CCNC(=O)C(=O)C(CC)NC(=O)C(CC(C)C)NC(=O)c1nccc2ccccc12 CHEMBL130580 Ki 350.0 nM
CCC(NC(=O)C(CC(C)C)NC(=O)OCc1ccccc1)C(=O)C(=O)NCC(O)c1ccc2ccccc2c1 CHEMBL421910 Ki 350.0 nM
CCC(NC(=O)C(CC(C)C)NC(=O)OCc1ccccc1)C(=O)C(=O)NCC(O)c1cccc(C(F)(F)F)c1 CHEMBL130629 Ki 350.0 nM
CNC(=O)C(=O)C(Cc1ccccc1)NC(=O)C(CC(C)C)NC(=O)OCc1ccccc1 CHEMBL133749 Ki 350.0 nM
CCCCN/C(=C1/N=CN(CCOC)C1=O)c1cc2ccccc2[nH]1 CHEMBL4281019 IC50 350.0 nM
CCC/C(=C\c1ccc(O)c(O)c1)C(=O)N[C@@H](Cc1ccccc1)C(=O)C(=O)NCc1ccccc1 CHEMBL1770881 IC50 360.0 nM
CCOP(=O)(C(=O)[C@@H](CC(C)C)NC(=O)C(CC(C)C)NC(=O)OCc1ccccc1)c1ccccc1 CHEMBL127322 IC50 370.0 nM
CN([C@H](COCc1ccccc1)C(=O)N[C@H](C=O)Cc1ccccc1)S(C)(=O)=O CHEMBL88703 Ki 370.0 nM
O=CC(Cc1ccccc1)NC(=O)c1ccccc1Cc1ccccc1 CHEMBL26381 Ki 370.0 nM
CCC(NC(=O)C(CC(C)C)NC(=O)OCc1ccccc1)C(=O)C(=O)NCCCN1CCCc2ccccc21 CHEMBL3706739 Ki 370.0 nM
CC(C)C[C@@H](C=O)NC(=O)[C@H](CCC(N)=O)NC(=O)OCc1ccccc1 CHEMBL150330 IC50 370.0 nM
CC(C)C[C@@H](/C=N/NC(=O)CN(C)C)NC(=O)[C@@H](NS(=O)(=O)c1ccc(F)cc1)C(C)C CHEMBL288882 IC50 370.0 nM
CCC(NC(=O)C(CC(C)C)NC(=O)OCc1ccccc1)C(=O)C(=O)NCC(O)c1cc(OC)c(OC)c(OC)c1 CHEMBL130359 Ki 380.0 nM
CC(C)CC(NC(=O)OCc1ccccc1)C(=O)NC(Cc1ccccc1)C(=O)C(=O)NCCCN1CCCc2ccccc21 CHEMBL3706740 Ki 380.0 nM
CCC(NC(=O)C(CC(C)C)NC(=O)OCc1ccccc1)C(=O)C(=O)NCCc1ccc(O)cc1 CHEMBL130753 Ki 380.0 nM
CNC(=O)C(=O)C(Cc1ccccc1)NC(=O)c1cccnc1-n1ccc(-c2ccccc2)n1 CHEMBL4293200 Ki 380.0 nM
COCCN/C(=C1/N=CN(CCOC)C1=O)c1cc2cccnc2[nH]1 CHEMBL4277940 IC50 380.0 nM
O=C(N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)CF)OCc1ccccc1 CHEMBL2368566 IC50 397.1 nM
CC(C)C(NC(=O)OCc1ccccc1)C(=O)N(CO)[C@H](C=O)Cc1ccccc1 CHEMBL80142 Ki 400.0 nM
CC(C)C(NC(=O)OCc1ccccc1)C(=O)N(C)[C@H](C=O)Cc1ccccc1 CHEMBL78324 Ki 400.0 nM
O=C(NCc1cn(-c2ccc3c(c2)OCO3)nn1)[C@H](Cc1cscn1)NC(=O)[C@H]1O[C@@H]1C(=O)O CHEMBL2408901 IC50 400.0 nM
CCC(NC(=O)C(CC(C)C)NC(=O)OCc1ccccc1)C(=O)C(=O)NCCc1ccccn1 CHEMBL132839 Ki 410.0 nM
CC(C)CC(=O)N[C@@H](Cc1ccccc1)C(=O)C(=O)NCCNS(=O)(=O)c1ccc(-c2ccccn2)s1 CHEMBL307883 Ki 420.0 nM
CCC(NC(=O)C(CC(C)C)NC(=O)OCc1ccccc1)C(=O)C(=O)NCC1(C)CC(O)CC(C)(C)C1 CHEMBL131781 Ki 420.0 nM
COCCOCCOCCOCCOCCOC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)C(=O)NC1CC1 CHEMBL455277 IC50 420.0 nM
COP(=O)(OC)C(=O)[C@@H](CC(C)C)NC(=O)C(CC(C)C)NC(=O)OCc1ccccc1 CHEMBL127716 IC50 430.0 nM
O=C(NCCNS(=O)(=O)c1ccc(-c2ccccn2)s1)C(=O)[C@H](Cc1ccccc1)NC(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 CHEMBL431198 Ki 430.0 nM
O=CC(Cc1ccccc1)NC(=O)c1ccccc1COc1ccccc1 CHEMBL280652 Ki 450.0 nM
O=CC(Cc1ccccc1)NC(=O)c1ccccc1C#Cc1ccccc1 CHEMBL27250 Ki 450.0 nM
NC(=O)C(=O)C(Cc1ccccc1)NC(=O)C1CCN(S(=O)(=O)c2ccc3ccccc3c2)CC1 CHEMBL307829 Ki 450.0 nM
CCc1c(C(=O)N[C@@H](Cc2ccccc2)C(=O)C(N)=O)oc2ccccc2c1=O CHEMBL196671 IC50 450.0 nM
CC(C)CC(NC(=O)OCc1ccccc1)C(=O)NC(Cc1ccccc1)C(=O)C(=O)NCC(O)c1cccc(C(F)(F)F)c1 CHEMBL435203 Ki 460.0 nM
NC(=O)C(=O)C(Cc1ccccc1)NC(=O)C1CCN(C(=O)/C=C/c2ccccc2)CC1 CHEMBL70044 Ki 460.0 nM
CC/C(=C\c1ccc(O)c(O)c1)C(=O)N[C@@H](Cc1ccccc1)C(=O)C(=O)NCCc1ccc(OC)cc1 CHEMBL1770880 IC50 460.0 nM
COCCN/C(=C1/N=CN(CCOC)C1=O)c1cc2ccccc2[nH]1 CHEMBL4285250 IC50 460.0 nM
C=CCNC(=O)C(=O)C(Cc1ccccc1)NC(=O)c1cccnc1-n1ccc(-c2ccccc2)n1 CHEMBL4292149 Ki 470.0 nM
CC(C)CC(NC(=O)OCc1ccccc1)C(=O)NC(Cc1ccccc1)C(=O)C(=O)NCC(O)c1ccc(OCc2ccccc2)c(OCc2ccccc2)c1 CHEMBL133806 Ki 480.0 nM
CCCNC(=O)C(=O)C(Cc1ccccc1)NC(=O)c1cccnc1-n1ccc(-c2ccccc2)n1 CHEMBL4288728 Ki 480.0 nM
O=C(NC1CCC1)C(=O)C(Cc1ccccc1)NC(=O)c1cccnc1-n1ccc(-c2ccccc2)n1 CHEMBL4284950 Ki 490.0 nM
Cc1cc(O)ccc1-n1cc(C(N)=O)c(=O)c2ccc(-c3ccncc3)cc21 CHEMBL340921 IC50 500.0 nM
NC(=O)c1cn(-c2ccc(O)cc2Cl)c2cc(-c3ccncc3)ccc2c1=O CHEMBL340384 IC50 500.0 nM
CC(C)CCNC(=O)[C@H](CC(C)C)NC(=O)[C@H]1O[C@@H]1C(=O)OCCF CHEMBL294046 I50 500.0 nM
CCCCNC(=O)C(=O)[C@H](CC(C)C)NC(=O)C1Cc2cc3c(cc2S(=O)(=O)N1CC)OCCO3 CHEMBL1793864 IC50 500.0 nM
CCN1C(C(=O)N[C@@H](Cc2ccccc2)C(=O)C(=O)NCCCN2CCCC2=O)Cc2cc3c(cc2S1(=O)=O)OCCO3 CHEMBL8688 IC50 500.0 nM
CCC(NC(=O)C(CC(C)C)NC(=O)C(c1ccccc1)c1ccccc1)C(=O)C(=O)NCc1ccccn1 CHEMBL423704 Ki 500.0 nM
CC(C)C[C@@H](CCS(=O)(=O)c1ccc2ccccc2c1)C(=O)N[C@H](C=O)CC(C)C CHEMBL316721 IC50 500.0 nM
CCC(NC(=O)C(CC(C)C)NC(=O)OCc1ccccc1)C(=O)C(=O)NCC(OC)OC CHEMBL334744 Ki 500.0 nM
CCC(NC(=O)C(CC(C)C)NC(=O)OCc1ccccc1)C(=O)C(=O)NCCCCCO CHEMBL133106 Ki 500.0 nM
CCNC(=O)C(=O)C(CC)NC(=O)C(CC(C)C)NC(=O)c1ccc2ccccc2n1 CHEMBL131707 Ki 500.0 nM
CCCC/C(=C\c1ccc(O)c(O)c1)C(=O)N[C@@H](Cc1ccccc1)C(=O)C(=O)NCCc1ccc(OC)cc1 CHEMBL1771024 IC50 500.0 nM
COc1ccc(OC)c(C(=O)CCC(=O)N[C@@H](Cc2ccccc2)C(=O)C(N)=O)c1 CHEMBL467750 IC50 520.0 nM
NC(=O)C(=O)C(Cc1ccccc1)NC(=O)[C@@H]1CCC(=O)N1Cc1ccccc1 CHEMBL4571978 Ki 528.0 nM
CC(C)C[C@@H](C=O)NC(=O)[C@H](CO)NC(=O)OCc1ccccc1 CHEMBL149969 IC50 530.0 nM
Cc1c(C(=O)N[C@@H](Cc2ccccc2)C(=O)C(=O)NCCc2ccccc2)oc2ccccc2c1=O CHEMBL382711 IC50 530.0 nM
O=C(Nc1nc2ccc(F)cc2s1)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1O[C@@H]1C(=O)O CHEMBL2408914 IC50 530.0 nM
O=C(Nc1nc2ccc(F)cc2s1)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1O[C@@H]1C(=O)O CHEMBL3929814 IC50 530.0 nM
Cn1cc(CN2C(=O)CC[C@@H]2C(=O)NC(Cc2ccccc2)C(=O)C(=O)NC2CN2)cn1 CHEMBL4452603 Ki 530.0 nM
COc1ccccc1C(=O)CCC(=O)N[C@@H](Cc1ccccc1)C(=O)C(N)=O CHEMBL460813 IC50 540.0 nM
O=C(NC1CC1)C(=O)C(Cc1ccccc1)NC(=O)[C@H]1CCC(=O)N1C1Cc2ccccc2C1 CHEMBL4535145 Ki 545.0 nM
O=C(NCC1CC1)C(=O)C(Cc1ccccc1)NC(=O)c1cccnc1-n1ccc(-c2ccccc2)n1 CHEMBL4279559 Ki 550.0 nM
NC(=O)C(=O)C(Cc1ccccc1)NC(=O)C1CCN(C(=O)c2ccccc2)CC1 CHEMBL409426 Ki 560.0 nM
O=C(NCCNS(=O)(=O)c1ccc(-c2ccccn2)s1)C(=O)[C@H](Cc1ccccc1)NC(=O)c1ccccc1 CHEMBL76302 Ki 570.0 nM
CC(C)C[C@@H](C=O)NC(=O)[C@H](CC1CCCCC1)NC(=O)OCc1ccccc1 CHEMBL151913 IC50 580.0 nM
CC(C)CC(NC(=O)OCc1ccccc1)C(=O)NC(Cc1ccccc1)C(=O)C(=O)NCC(O)c1cccc(Oc2ccc(Cl)c(Cl)c2)c1 CHEMBL133707 Ki 590.0 nM
CCOC(=O)[C@@H](CC(C)C)NC(=O)C(CC(C)C)NC(=O)OCc1ccccc1 CHEMBL338647 IC50 600.0 nM
NC(=O)c1cn(-c2ccc(O)cc2Cl)c2cc(-n3cccn3)ccc2c1=O CHEMBL340210 IC50 600.0 nM
CC(C)CC(NC(=O)OCc1ccccc1)C(=O)NC(Cc1ccccc1)C(=O)C(=O)NCC(O)c1cccc(Oc2ccccc2)c1 CHEMBL337684 Ki 600.0 nM
CC[C@H](C)[C@H](NC(=S)Nc1ccccc1)C(=O)N[C@H]1CCOC1O CHEMBL208986 IC50 600.0 nM
CC/C(=C\c1ccc(O)c(O)c1)C(=O)N[C@@H](Cc1ccccc1)C(=O)C(=O)NCc1ccccc1 CHEMBL1770879 IC50 610.0 nM
CC(C)CC(NC(=O)OCc1ccccc1)C(=O)NC(Cc1ccccc1)C(=O)C(=O)NCC(O)c1ccc(N(C)C)cc1 CHEMBL132732 Ki 620.0 nM
CC(C)[C@H](NS(=O)(=O)c1ccc(F)cc1)C(=O)N[C@H](C)C=O CHEMBL354575 IC50 630.0 nM
CC(C)[C@H](NC(=S)Nc1ccccc1)C(=O)N[C@H]1CCOC1O CHEMBL377197 IC50 630.0 nM
CCCC/C(=C\c1ccc(O)c(OC)c1)C(=O)N[C@@H](Cc1ccccc1)C(=O)C(=O)NCCc1ccc(OC)cc1 CHEMBL1771026 IC50 630.0 nM
CCC(NC(=O)C(CC(C)C)NC(=O)OCc1ccccc1)C(=O)C(=O)NCc1ccccn1 CHEMBL130114 Ki 640.0 nM
CC(C)CC(NC(=O)OCc1ccccc1)C(=O)NC(Cc1ccccc1)C(=O)C(=O)NCc1ccccn1 CHEMBL129933 Ki 650.0 nM
CCC(NC(=O)C(CC(C)C)NC(=O)OCc1ccccc1)C(=O)C(=O)NCCNC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@@H]21 CHEMBL273817 Ki 650.0 nM
CCC(NC(=O)C(CC(C)C)NC(=O)OCc1ccccc1)C(=O)C(=O)NCCOCCO CHEMBL131264 Ki 650.0 nM
NC(=O)C(=O)C(Cc1ccccc1)NC(=O)C1CCN(C(=O)c2cnc3ccccc3c2)CC1 CHEMBL304400 Ki 670.0 nM
CCCC/C(=C\c1ccc(O)c(O)c1)C(=O)N[C@@H](Cc1ccccc1)C(=O)C(=O)NCc1ccccc1 CHEMBL1771023 IC50 670.0 nM
CCC(NC(=O)C(CC(C)C)NC(=O)OCc1ccccc1)C(=O)C(=O)NCC1CCCCC1 CHEMBL117888 Ki 680.0 nM
CCNC(=O)C(=O)C(Cc1ccccc1)NC(=O)c1cccnc1-n1ccc(-c2ccccc2)n1 CHEMBL4285376 Ki 690.0 nM
COc1cc2c(cc1OC)S(=O)(=O)NC(C(=O)N[C@H](C=O)Cc1ccccc1)C2 CHEMBL323656 IC50 700.0 nM
CC(C)CCNC(=O)[C@H](CC(C)C)NC(=O)[C@H]1O[C@@H]1C(=O)OCC(Cl)(Cl)Cl CHEMBL61010 I50 700.0 nM
CC(C)CC(NC(=O)OCc1ccccc1)C(=O)NC(Cc1ccccc1)C(=O)C(=O)NCC(O)c1c(F)c(F)c(F)c(F)c1F CHEMBL339174 Ki 700.0 nM
COCOc1cc(OC)ccc1C(=O)CCC(=O)N[C@@H](Cc1ccccc1)C(=O)C(N)=O CHEMBL459288 IC50 700.0 nM
Cc1c(C(=O)N[C@@H](Cc2ccccc2)C(=O)C(N)=O)[nH]c2ccccc2c1=O CHEMBL254142 IC50 710.0 nM
CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)C(=O)N[C@@H](C)C(=O)O CHEMBL316645 Ki 718.0 nM
Cc1c(C(=O)N[C@@H](Cc2ccccc2)C(=O)C(=O)NCc2ccccc2)oc2ccccc2c1=O CHEMBL195992 IC50 720.0 nM
COc1ccc(CCNC(=O)C(=O)[C@H](Cc2ccccc2)NC(=O)c2[nH]c3ccccc3c(=O)c2C)cc1 CHEMBL253315 IC50 730.0 nM
CCC(NC(=O)C(CC(C)C)NC(=O)C(c1ccccc1)c1ccccc1)C(=O)C(=O)NCC(O)c1ccccc1 CHEMBL132526 Ki 750.0 nM
CC(C)CC(NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NC(Cc1ccccc1)C(=O)C(=O)NCCCN1CCOCC1 CHEMBL132587 Ki 760.0 nM
CN1C(=O)[C@H](Cc2ccc(O)cc2)N(C)C(=O)[C@@H]1Cc1ccc(O)cc1 CHEMBL89560 IC50 800.0 nM
CCC(NC(=O)C(CC(C)C)NC(=O)OCc1ccccc1)C(=O)C(=O)NCCCc1ccccc1 CHEMBL119622 Ki 800.0 nM
CCC(NC(=O)C(CC(C)C)NC(=O)C(c1ccccc1)c1ccccc1)C(=O)C(=O)NCCCN1CCOCC1 CHEMBL132886 Ki 800.0 nM
CCC(NC(=O)C(CC(C)C)NC(=O)OCc1ccccc1)C(=O)C(=O)NCCO CHEMBL134121 Ki 800.0 nM
CCC(NC(=O)C(CC(C)C)NC(=O)OCc1ccccc1)C(=O)C(=O)NCc1ccco1 CHEMBL424074 Ki 800.0 nM
O=C(NCCCN1CCOCC1)C(=O)C(Cc1ccccc1)NC(=O)C1CCN(S(=O)(=O)c2ccc3ccccc3c2)CC1 CHEMBL69254 Ki 810.0 nM
Cc1c(C(=O)N[C@@H](Cc2ccccc2)C(=O)C(N)=O)oc2cc3c(cc2c1=O)OCCO3 CHEMBL382964 IC50 810.0 nM
CC(C)C[C@H](C=O)NC(=O)[C@@H](NS(C)(=O)=O)C(C)C CHEMBL169121 IC50 830.0 nM
CCNC(=O)C(=O)C(CC)NC(=O)C(CC(C)C)NC(=O)c1ccco1 CHEMBL131257 Ki 850.0 nM
CC(C)[C@H](NS(=O)(=O)c1ccc(F)cc1)C(=O)N[C@H]1CCOC1O CHEMBL209736 IC50 880.0 nM
CCC(NC(=O)C(CC(C)C)NC(=O)OCc1ccccc1)C(=O)C(=O)NCC(O)c1cccc(Oc2ccccc2)c1 CHEMBL341219 Ki 900.0 nM
Cc1ccc(NC(=S)N[C@@H](CC(C)C)C(=O)N[C@H]2CCOC2O)cc1 CHEMBL378215 IC50 910.0 nM
COc1ccc(CCNC(=O)C(=O)[C@H](Cc2ccccc2)NC(=O)CCC(=O)c2cc(OC)ccc2OC)cc1 CHEMBL462912 IC50 950.0 nM
N#CCNC(=O)C(=O)C(Cc1ccccc1)NC(=O)c1cccnc1-n1ccc(-c2ccccc2)n1 CHEMBL4281522 Ki 950.0 nM
O=C(NCCCN1CCOCC1)C(=O)C(Cc1ccccc1)NC(=O)C1CCN(C(=O)c2ccc3ccccc3c2)CC1 CHEMBL69466 Ki 960.0 nM
CC(C)CCNC(=O)[C@H](CC(C)C)NC(=O)[C@H]1O[C@@H]1C(=O)OCCBr CHEMBL63494 I50 1000.0 nM
CCNC(=O)C(=O)[C@H](Cc1ccccc1)NC(=O)C1Cc2cc(Cl)ccc2S(=O)(=O)N1CC CHEMBL266784 IC50 1000.0 nM
CCN1C(C(=O)N[C@@H](Cc2ccccc2)C(=O)C(=O)OC)Cc2cc3c(cc2S1(=O)=O)OCCO3 CHEMBL8860 IC50 1000.0 nM
CCC(NC(=O)C(CC(C)C)NC(=O)OCc1ccccc1)C(=O)C(=O)NCCN1CCOCC1 CHEMBL130107 Ki 1000.0 nM
O=C(NCc1cn(-c2ccccc2)nn1)[C@H](Cc1cscn1)NC(=O)[C@H]1O[C@@H]1C(=O)O CHEMBL2408898 IC50 1000.0 nM
CC(=O)NCCCCNC(=O)[C@H](CC(C)C)NC(=O)C1OC1c1ccccc1 CHEMBL3974202 IC50 1000.0 nM
O=C(O)[C@H]1O[C@@H]1C(=O)NC1(C(=O)NCCCCNS(=O)(=O)c2ccc(F)cc2)CCCCC1 CHEMBL3920009 IC50 1000.0 nM