C=CCOc1ccc(CN2C(=O)C(=O)c3cc(S(=O)(=O)N4CCC[C@H]4COC)ccc32)cc1 CHEMBL467252 IC50 0.6 nM
COC[C@@H]1CCCN1S(=O)(=O)c1ccc2c(c1)C(=O)C(=O)N2CC[C@H](F)CO CHEMBL2381343 IC50 0.951 nM
COC[C@@H]1CCCN1S(=O)(=O)c1ccc2c(c1)C(=O)C(=O)N2Cc1ccc(I)cc1 CHEMBL217457 IC50 1.8 nM
COC[C@@H]1CCCN1S(=O)(=O)c1ccc2c(c1)C(=O)C(=O)N2Cc1ccc(C2CO2)cc1 CHEMBL523666 IC50 1.9 nM
O=C1C(=O)N(Cc2cn(CCF)nn2)c2ccc(S(=O)(=O)N3CCC[C@H]3COc3ccc(F)cc3F)cc21 CHEMBL456799 EC50 2.2 nM
O=C1C(=O)N(Cc2ccc(F)cc2)c2ccc(S(=O)(=O)N3CCC[C@H]3COc3ccncn3)cc21 CHEMBL515506 EC50 2.3 nM
COC[C@@H]1CCCN1S(=O)(=O)c1ccc2c(c1)C(=O)C(=O)N2Cc1ccc(OCC2CO2)cc1 CHEMBL494220 IC50 2.4 nM
CC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)N[C@H](C=O)CC(=O)O)C(C)C CHEMBL417149 IC50 2.9 nM
CCCCN1C(=O)C(=O)c2cc(S(=O)(=O)N3CCC[C@H]3COC)cc(Br)c21 CHEMBL3359194 IC50 3.3 nM
O=C1C(=O)N(Cc2cn(CCF)nn2)c2ccc(S(=O)(=O)N3CCC[C@H]3COc3cccnc3)cc21 CHEMBL1762363 IC50 3.8 nM
COC[C@@H]1CCCN1S(=O)(=O)c1ccc2c(c1)C(=O)C(=O)N2Cc1ccc(OC)cc1 CHEMBL217777 IC50 4.0 nM
COC[C@@H]1CCCN1S(=O)(=O)c1ccc2c(c1)C(=O)C(=O)N2Cc1ccc(OCCF)cc1 CHEMBL215480 IC50 4.6 nM
COC[C@@H]1CCCN1S(=O)(=O)c1ccc2c(c1)C(=O)C(=O)N2Cc1ccc(OCC(O)CF)cc1 CHEMBL466422 IC50 5.0 nM
O=C1C(=O)N(Cc2ccc(I)cc2)c2ccc(S(=O)(=O)N3CCC[C@H]3CF)cc21 CHEMBL3133258 IC50 5.4 nM
O=C1C(=O)N(Cc2ccc(OCCF)cc2)c2ccc(S(=O)(=O)N3CCC[C@H]3COc3ccccc3)cc21 CHEMBL213759 IC50 5.9 nM
COC[C@@H]1CCCN1S(=O)(=O)c1cc(Br)c2c(c1)C(=O)C(=O)N2CCCCF CHEMBL3359196 IC50 5.95 nM
O=C1C(=O)N(Cc2ccccc2)c2ccc(S(=O)(=O)N3CCC[C@H]3COc3ccccc3)cc21 CHEMBL439753 Ki app 6.0 nM
O=C1C(=O)N(Cc2cn(CCF)nn2)c2ccc(S(=O)(=O)N3CC[C@H]3COc3cccnc3)cc21 CHEMBL1762362 IC50 6.1 nM
O=C1C(=O)N(Cc2ccc(Br)cc2)c2ccc(S(=O)(=O)N3CCC[C@H]3COc3cccnc3)cc21 CHEMBL227036 IC50 6.6 nM
COC[C@@H]1CCCN1S(=O)(=O)c1ccc2c(c1)C(=O)C(=O)N2CCC(C)F CHEMBL494141 IC50 6.8 nM
CC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)NC(CC(=O)O)C(=O)CF CHEMBL23226 IC50 7.0 nM
C=Cc1ccc(CN2C(=O)C(=O)c3cc(S(=O)(=O)N4CCC[C@H]4COC)ccc32)cc1 CHEMBL513663 IC50 7.2 nM
CCCCN1C(=O)C(=O)c2cc(S(=O)(=O)N3CCC[C@H]3COCC(F)(F)F)ccc21 CHEMBL2348860 IC50 7.47 nM
COC[C@@H]1CCCN1S(=O)(=O)c1ccc2c(c1)C(=O)C(=O)N2Cc1ccc(C(F)CO)cc1 CHEMBL492385 IC50 7.6 nM
CC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)CCCc1ccccc1)C(C)C CHEMBL443565 IC50 8.0 nM
CCC(C(=O)N[C@@H](CC(=O)O)C(=O)CCCc1ccccc1)n1cc(C(C)(C)C)nc(Nc2nnn[nH]2)c1=O CHEMBL248508 IC50 8.0 nM
O=C1C(=O)N(Cc2ccc(F)cc2)c2ccc(S(=O)(=O)N3CCC[C@H]3COc3ccc(F)cc3)cc21 CHEMBL516490 EC50 8.0 nM
CCCCN1C(=O)C(=O)c2cc(S(=O)(=O)N3CCC[C@H]3COC)ccc21 CHEMBL521840 IC50 8.1 nM
CC(C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)c1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)CCCc1ccccc1 CHEMBL352426 IC50 8.4 nM
COC[C@@H]1CCCN1S(=O)(=O)c1ccc2c(c1)C(=O)C(=O)N2C[C@H]1CO1 CHEMBL513297 IC50 9.0 nM
O=C(Nc1cccc(N2CCOCC2)c1)n1sc2ccccc2c1=O CHEMBL3233629 IC50 9.424 nM
COc1ccc(CN2C(=O)C(=O)c3cc(S(=O)(=O)N4CCC[C@H]4CF)ccc32)cc1 CHEMBL3133259 IC50 9.6 nM
O=C1C(=O)N(CCCCF)c2ccc(S(=O)(=O)N3CCC[C@H]3COCCF)cc21 CHEMBL2348702 IC50 9.68 nM
CCCCN1C(=O)C(=O)c2cc(S(=O)(=O)N3CCC[C@H]3COC)cc(F)c21 CHEMBL3359202 IC50 9.7 nM
CC(C)C[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)OCc1ccccc1)C(=O)N[C@H]1CC(=O)OC1O CHEMBL100588 IC50 10.0 nM
CC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)N[C@H]1CC(=O)OC1O)C(C)C CHEMBL430648 IC50 10.0 nM
CC(=O)N[C@@H](C(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)N[C@H]1CC(=O)OC1O)C(C)C CHEMBL328412 IC50 10.0 nM
CC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)CSCc1ccccc1)n1cccc(NC(=O)[C@H](CC(=O)O)NC(C)=O)c1=O CHEMBL178116 IC50 10.0 nM
CC(C)[C@H](NC(=O)OCc1ccc(Cl)cc1Cl)C(=O)NC(CC(=O)O)C(=O)CF CHEMBL185356 IC50 10.0 nM
COc1ccc(CN2C(=O)C(=O)c3cc(S(=O)(=O)N4CC[C@H]4COc4cccnc4)ccc32)cc1 CHEMBL1762350 IC50 10.2 nM
CC(C)[C@H](OC(=O)Nc1ccccc1)C(=O)NC(CC(=O)O)C(=O)CF CHEMBL180263 IC50 11.0 nM
CC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)Nc1ccccc1C(=O)NC(C(=O)O)C(=O)CF CHEMBL237310 IC50 11.0 nM
COC[C@@H]1CCCN1S(=O)(=O)c1ccc2c(c1)C(=O)C(=O)N2CCCCO CHEMBL522148 IC50 11.0 nM
COC[C@@H]1CCCN1S(=O)(=O)c1ccc2c(c1)C(=O)C(=O)N2Cc1ccc(C(F)(F)F)cc1 CHEMBL521822 IC50 11.0 nM
O=C1C(=O)N(Cc2ccc([N+](=O)[O-])cc2)c2ccc(S(=O)(=O)N3CCC[C@H]3CF)cc21 CHEMBL3133148 IC50 11.2 nM
O=C1C(=O)N(Cc2ccc(OCCF)cc2)c2ccc(S(=O)(=O)N3CCC[C@H]3COc3cccnc3)cc21 CHEMBL1762353 IC50 11.3 nM
O=C1C(=O)N(Cc2ccc(O)cc2)c2ccc(S(=O)(=O)N3CCC[C@H]3COc3cccnc3)cc21 CHEMBL227035 IC50 11.7 nM
O=C1C(=O)N(Cc2ccc(OCCOCCF)cc2)c2ccc(S(=O)(=O)N3CCC[C@H]3COc3ccccc3)cc21 CHEMBL1762351 IC50 11.9 nM
O=C1C(=O)N(Cc2ccc(OCCF)cc2)c2ccc(S(=O)(=O)N3CCC[C@H]3COc3ccc(F)cc3F)cc21 CHEMBL1762365 IC50 12.3 nM
COCC[C@@H]1CCCN1S(=O)(=O)c1ccc2c(c1)C(=O)C(=O)N2CCCCF CHEMBL2348693 IC50 12.3 nM
O=C1C(=O)N(Cc2cn(CCF)nn2)c2ccc(S(=O)(=O)N3CCC[C@H]3COc3ccccc3)cc21 CHEMBL456798 IC50 12.4 nM
CCCCCCN(C)CC(=O)C(CC(=O)O)NC(=O)C(CC)n1cc(C(C)(C)C)nc(NCc2nonc2C)c1=O CHEMBL366927 IC50 13.0 nM
O=C1C(=O)N(Cc2ccc(F)cc2)c2ccc(S(=O)(=O)N3CCC[C@H]3COc3ccc(F)cc3F)cc21 CHEMBL516941 EC50 13.0 nM
CCOC[C@@H]1CCCN1S(=O)(=O)c1ccc2c(c1)C(=O)C(=O)N2 CHEMBL2348697 IC50 13.2 nM
O=C1C(=O)N(Cc2ccc(F)cc2)c2ccc(S(=O)(=O)N3CCC[C@H]3COc3cccc(F)c3)cc21 CHEMBL461249 EC50 13.5 nM
COC[C@@H]1CCCN1S(=O)(=O)c1ccc2c(c1)C(=O)C(=O)N2Cc1ccc(OCCOS(=O)(=O)c2ccc(C)cc2)cc1 CHEMBL216071 IC50 13.8 nM
O=C1C(=O)N(Cc2ccc(F)cc2)c2ccc(S(=O)(=O)N3CCC[C@H]3CF)cc21 CHEMBL3133255 IC50 14.0 nM
O=C1C(=O)N(Cc2ccccc2)c2ccc(S(=O)(=O)N3CCC[C@H]3COc3cccnc3)cc21 CHEMBL197549 IC50 14.1 nM
O=C1C(=O)N(Cc2ccc(Cl)cc2)c2ccc(S(=O)(=O)N3CCC[C@H]3CF)cc21 CHEMBL3133254 IC50 14.2 nM
O=C1C(=O)N(Cc2ccc(F)cc2)c2ccc(S(=O)(=O)N3CCC[C@H]3COC3CCOCC3)cc21 CHEMBL456593 EC50 14.4 nM
O=C1C(=O)N(Cc2ccc(F)nc2)c2ccc(S(=O)(=O)N3CCC[C@H]3COc3ccccc3)cc21 CHEMBL200653 IC50 14.5 nM
O=C1C(=O)N(Cc2ccc(F)cc2)c2ccc(S(=O)(=O)N3CCC[C@H]3COc3cccnc3)cc21 CHEMBL198682 IC50 15.1 nM
COc1ccc(CN2C(=O)C(=O)c3cc(S(=O)(=O)N4CCC[C@H]4COc4cccnc4)ccc32)cc1 CHEMBL372322 IC50 15.1 nM
O=C1C(=O)N(Cc2cn(CCF)nn2)c2ccc(S(=O)(=O)N3CC[C@H]3COc3ccc(F)cc3F)cc21 CHEMBL1762366 IC50 15.3 nM
O=C1C(=O)N(Cc2ccc(OCCF)cc2)c2ccc(S(=O)(=O)N3CC[C@H]3COc3ccc(F)cc3F)cc21 CHEMBL1762364 IC50 15.4 nM
O=C1C(=O)N(Cc2ccc(Br)cc2)c2ccc(S(=O)(=O)N3CCC[C@H]3CF)cc21 CHEMBL3133253 IC50 15.9 nM
COC[C@@H]1CCCN1S(=O)(=O)c1ccc2c(c1)C(=O)C(=O)N2Cc1ccc(C(F)CBr)cc1 CHEMBL467251 IC50 16.0 nM
O=C1C(=O)N(Cc2cccc([N+](=O)[O-])c2)c2ccc(S(=O)(=O)N3CCC[C@H]3CF)cc21 CHEMBL3133147 IC50 16.5 nM
O=C1C(=O)N(Cc2ccc(F)cc2)c2ccc(S(=O)(=O)N3CCC[C@H]3COc3cc(F)cc(F)c3)cc21 CHEMBL456592 EC50 16.8 nM
O=C1C(=O)N(Cc2ccc(F)nc2)c2ccc(S(=O)(=O)N3CC[C@H]3COc3ccccc3)cc21 CHEMBL370012 IC50 17.0 nM
O=C1C(=O)N(Cc2ccc(OCCF)cc2)c2ccc(S(=O)(=O)N3CC[C@H]3COc3cccnc3)cc21 CHEMBL1762349 IC50 17.6 nM
O=C1C(=O)N(Cc2ccc(OCCOCCOCCF)cc2)c2ccc(S(=O)(=O)N3CCC[C@H]3COc3ccccc3)cc21 CHEMBL1762352 IC50 17.6 nM
O=C1C(=O)N(Cc2cn(CCF)nn2)c2ccc(S(=O)(=O)N3CC[C@H]3COc3ccccc3)cc21 CHEMBL1762361 IC50 18.0 nM
O=C1C(=O)N(Cc2ccc(F)cc2)c2ccc(S(=O)(=O)N3CCC[C@H]3COCc3cn(CCF)nn3)cc21 CHEMBL518382 EC50 18.3 nM
O=C1C(=O)N(Cc2ccc(I)cc2)c2ccc(S(=O)(=O)N3CCC[C@H]3COc3ccccc3)cc21 CHEMBL384023 IC50 18.6 nM
O=C1C(=O)N(Cc2ccc(OCCOCCOCCF)cc2)c2ccc(S(=O)(=O)N3CC[C@H]3COc3ccccc3)cc21 CHEMBL1762348 IC50 19.2 nM
O=C1C(=O)N(Cc2ccc(F)cc2)c2ccc(S(=O)(=O)N3CCC[C@H]3COc3ccccc3)cc21 CHEMBL372607 EC50 19.8 nM
O=C1C(=O)N(Cc2ccccc2[N+](=O)[O-])c2ccc(S(=O)(=O)N3CCC[C@H]3CF)cc21 CHEMBL3133146 IC50 19.8 nM
CCN1C(=O)C(=O)c2cc(S(=O)(=O)N3CCC[C@H]3COC)cc(I)c21 CHEMBL3359184 IC50 20.1 nM
COC[C@@H]1CCCN1S(=O)(=O)c1cc(Br)c2c(c1)C(=O)C(=O)N2CCCF CHEMBL3359195 IC50 20.1 nM
O=C1C(=O)N(Cc2ccccc2)c2ccc(S(=O)(=O)N3CCC[C@H]3CF)cc21 CHEMBL3133252 IC50 20.4 nM
O=C1C(=O)N(Cc2ccc(F)cc2)c2ccc(S(=O)(=O)N3CC[C@H]3COc3ccccc3)cc21 CHEMBL200886 IC50 21.0 nM
COc1ccc(CN2C(=O)C(=O)c3cc(S(=O)(=O)N4CCC[C@H]4COc4ccccc4)ccc32)cc1 CHEMBL200677 IC50 21.8 nM
O=C1C(=O)N(Cc2cccc(I)c2)c2ccc(S(=O)(=O)N3CCC[C@H]3CF)cc21 CHEMBL3133257 IC50 21.8 nM
O=C1C(=O)N(Cc2cccc(F)n2)c2ccc(S(=O)(=O)N3CCC[C@H]3COc3ccccc3)cc21 CHEMBL372994 IC50 22.2 nM
O=C1C(=O)N(Cc2cccc(F)n2)c2ccc(S(=O)(=O)N3CC[C@H]3COc3ccccc3)cc21 CHEMBL371687 IC50 22.7 nM
COC[C@@H]1CCCN1S(=O)(=O)c1cc(Br)c2c(c1)C(=O)C(=O)N2CCCCO CHEMBL3359197 IC50 22.7 nM
COc1ccc(CN2C(=O)C(=O)c3cc(S(=O)(=O)N4CC[C@H]4COc4ccccc4)ccc32)cc1 CHEMBL200813 IC50 23.2 nM
CSc1ccc(CN2C(=O)C(=O)c3cc(S(=O)(=O)N4CCC[C@H]4COc4cccnc4)ccc32)cc1 CHEMBL198755 IC50 23.3 nM
CCOc1ccc(/C=C/C(=O)OC)cc1CC(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)CSCc1c(F)cccc1Cl)C(C)C CHEMBL81038 IC50 24.0 nM
C=CCN1C(=O)C(=O)c2cc(S(=O)(=O)N3CCC[C@H]3COC)ccc21 CHEMBL512101 IC50 24.0 nM
O=C1C(=O)N(Cc2ccccc2I)c2ccc(S(=O)(=O)N3CCC[C@H]3CF)cc21 CHEMBL3133256 IC50 24.0 nM
CCCCN1C(=O)C(=O)c2cc(S(=O)(=O)N3CCC[C@H]3CCOC)ccc21 CHEMBL2348692 IC50 24.6 nM
O=C1C(=O)N(Cc2nnnn2Cc2ccccc2)c2ccc(S(=O)(=O)N3CCC[C@H]3CF)cc21 CHEMBL3133149 IC50 25.3 nM
COC[C@@H]1CCCN1S(=O)(=O)c1ccc2c(c1)C(=O)C(=O)N2Cc1ccc(OCCBr)cc1 CHEMBL216447 IC50 25.7 nM
O=C1C(=O)N(Cc2ccccc2F)c2ccc(S(=O)(=O)N3CC[C@H]3COc3ccccc3)cc21 CHEMBL200493 IC50 26.0 nM
O=C1C(=O)N(Cc2ccc(OCCF)cc2)c2ccc(S(=O)(=O)N3CC[C@H]3COc3ccccc3)cc21 CHEMBL1762346 IC50 26.1 nM
N#CC(C#N)=C1C(=O)N(Cc2ccc(Br)cc2)c2ccc(S(=O)(=O)N3CCC[C@H]3COc3cccnc3)cc21 CHEMBL387556 IC50 26.3 nM
N#CC(C#N)=C1C(=O)N(Cc2ccc(OCCF)cc2)c2ccc(S(=O)(=O)N3CCC[C@H]3COc3cccnc3)cc21 CHEMBL1762360 IC50 26.5 nM
CSc1ccc(CN2C(=O)C(=O)c3cc(S(=O)(=O)N4CC[C@H]4COc4ccccc4)ccc32)cc1 CHEMBL382084 IC50 26.7 nM
COC[C@@H]1CCCN1S(=O)(=O)c1ccc2c(c1)C(=O)C(=O)N2CC[C@H](O)CF CHEMBL2381345 IC50 27.0 nM
COC[C@@H]1CCCN1S(=O)(=O)c1ccc2c(c1)C(=O)C(=O)N2CCCCF CHEMBL494140 IC50 28.0 nM
N#CC(C#N)=C1C(=O)N(Cc2ccc(O)cc2)c2ccc(S(=O)(=O)N3CCC[C@H]3COc3cccnc3)cc21 CHEMBL226881 IC50 28.3 nM
O=C1C(=O)N(Cc2ccc(OCCOCCF)cc2)c2ccc(S(=O)(=O)N3CC[C@H]3COc3ccccc3)cc21 CHEMBL1762347 IC50 28.9 nM
COC[C@@H]1CCCN1S(=O)(=O)c1ccc2c(c1)C(=O)C(=O)N2CCCCOS(=O)(=O)c1ccc(C)cc1 CHEMBL492518 IC50 29.0 nM
O=C1C(=O)N(Cc2ccccc2)c2ccc(S(=O)(=O)N3CC[C@H]3COc3ccccc3)cc21 CHEMBL200785 IC50 29.5 nM
COc1ccc(CN2C(=O)C(=C(C#N)C#N)c3cc(S(=O)(=O)N4CCC[C@H]4COc4cccnc4)ccc32)cc1 CHEMBL427284 IC50 29.6 nM
O=C(NCCc1cccs1)n1sc2ccccc2c1=O CHEMBL3233626 IC50 30.87 nM
COC[C@@H]1CCCN1S(=O)(=O)c1ccc2c(c1)C(=O)C(=O)N2Cc1ccc(O)cc1 CHEMBL217220 IC50 32.3 nM
N#CC(C#N)=C1C(=O)N(Cc2ccccc2)c2ccc(S(=O)(=O)N3CCC[C@H]3COc3cccnc3)cc21 CHEMBL226828 IC50 32.8 nM
COCCCC1CCCN1S(=O)(=O)c1ccc2c(c1)C(=O)C(=O)N2CCCCF CHEMBL2348696 IC50 33.7 nM
CC(=O)Oc1ccc(CN2C(=O)C(=O)c3cc(S(=O)(=O)N4CCC[C@H]4COc4ccccc4)ccc32)cc1 CHEMBL200476 IC50 34.8 nM
O=C1C(=O)N(Cc2ccc(Br)cc2)c2ccc(S(=O)(=O)N3CCC[C@H]3COc3ccccc3)cc21 CHEMBL376112 IC50 34.8 nM
CCCCCN(C)CNCC(=O)[C@H](CC(=O)O)NC(=O)C(CC)n1cc(C(C)(C)C)nc(NCc2nonc2C)c1=O CHEMBL180669 IC50 36.0 nM
COC[C@@H]1CCCN1S(=O)(=O)c1cc(F)c2c(c1)C(=O)C(=O)N2CCCF CHEMBL3359203 IC50 39.3 nM
CCCCN1C(=O)C(=O)c2cc(S(=O)(=O)N3CCC[C@H]3COCCF)ccc21 CHEMBL2348701 IC50 39.6 nM
COC[C@@H]1CCCN1S(=O)(=O)c1ccc2c(c1)C(=O)C(=O)N2CCC(F)(F)F CHEMBL475859 IC50 40.0 nM
CC(C)[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)OCc1ccccc1)C(=O)N[C@H](/C=C/S(C)(=O)=O)CC(=O)O CHEMBL3673265 IC50 40.0 nM
CSc1ccc(CN2C(=O)C(=O)c3cc(S(=O)(=O)N4CCC[C@H]4COc4ccccc4)ccc32)cc1 CHEMBL200220 IC50 41.0 nM
O=C1C(=O)N(Cc2ccc(OCCF)cc2)c2ccc(S(=O)(=O)N3CCC[C@H]3CF)cc21 CHEMBL3133251 IC50 41.4 nM
CCCCCCN(C)CNCC(=O)[C@H](CC(=O)O)NC(=O)C(CC)n1cc(C(C)(C)C)nc(NCc2nonc2C)c1=O CHEMBL361825 IC50 42.0 nM
O=C1C(=O)N(Cc2ccc(OCCBr)cc2)c2ccc(S(=O)(=O)N3CCC[C@H]3COc3ccccc3)cc21 CHEMBL385930 IC50 42.0 nM
CCCCCCN(C)CC(=O)C(CC(=O)O)NC(=O)[C@H](CC)n1cc(C(C)(C)C)nc(NCc2nonc2C)c1=O CHEMBL5280661 IC50 42.0 nM
CCCN1C(=O)C(=O)c2cc(S(=O)(=O)N3CCC[C@H]3COC)cc(I)c21 CHEMBL3359185 IC50 42.4 nM
COC[C@@H]1CCCN1S(=O)(=O)c1ccc2c(c1)C(=O)C(=O)N2C[C@H](O)CO CHEMBL511723 IC50 43.0 nM
O=C1C(=O)N(Cc2ccc(O)cc2)c2ccc(S(=O)(=O)N3CCC[C@H]3COc3ccccc3)cc21 CHEMBL200927 IC50 44.0 nM
COC[C@@H]1CCCN1S(=O)(=O)c1ccc2c(c1)C(=O)C(=O)N2Cc1ccc(F)cc1 CHEMBL493124 IC50 44.0 nM
N#CC(C#N)=C1C(=O)N(Cc2ccc(OCCF)cc2)c2ccc(S(=O)(=O)N3CC[C@H]3COc3cccnc3)cc21 CHEMBL1762356 IC50 45.0 nM
CN1C(=O)C(=O)c2cc(S(=O)(=O)N3CCC[C@H]3COc3ccccc3)ccc21 CHEMBL293034 Ki app 47.0 nM
O=C1Nc2ccc(S(=O)(=O)N3CCC[C@H]3COc3ccccc3)cc2C1=O CHEMBL62993 Ki app 47.0 nM
O=C1Nc2ccc(S(=O)(=O)N3CCC[C@H]3CNc3ccccc3)cc2C1=O CHEMBL1907830 Ki app 47.0 nM
C=CCCN1C(=O)C(=O)c2cc(S(=O)(=O)N3CCC[C@H]3COC)ccc21 CHEMBL468088 IC50 50.0 nM
COc1ccc(CN2C(=O)C(=C(C#N)C#N)c3cc(S(=O)(=O)N4CC[C@H]4COc4cccnc4)ccc32)cc1 CHEMBL1762357 IC50 50.0 nM
Cc1ccc(S(=O)(=O)OCCOc2ccc(CN3C(=O)C(=O)c4cc(S(=O)(=O)N5CCC[C@H]5COc5ccccc5)ccc43)cc2)cc1 CHEMBL386510 IC50 50.9 nM
N#CC(C#N)=C1C(=O)N(Cc2ccccc2)c2ccc(S(=O)(=O)N3CCC[C@H]3COc3ccccc3)cc21 CHEMBL226779 IC50 51.7 nM
COc1ccc(CCC(=O)n2sc3ccccc3c2=O)cc1 CHEMBL3360048 IC50 51.9 nM
COC[C@@H]1CCCN1S(=O)(=O)c1ccc2c(c1)C(=O)C(=O)N2CCCO CHEMBL522324 IC50 52.0 nM
COc1cccc(CCC(=O)n2sc3ccccc3c2=O)c1 CHEMBL3360047 IC50 54.0 nM
COC[C@@H]1CCCN1S(=O)(=O)c1cc(Cl)c2c(c1)C(=O)C(=O)N2CCCF CHEMBL3359200 IC50 55.7 nM
O=C(CCC(=O)n1sc2ccccc2c1=O)c1cccs1 CHEMBL3360059 IC50 56.7 nM
O=C1C(=O)N(Cc2ccnc(F)c2)c2ccc(S(=O)(=O)N3CCC[C@H]3COc3ccccc3)cc21 CHEMBL373012 IC50 58.0 nM
CCCN1C(=O)C(=O)c2cc(S(=O)(=O)N3CCC[C@H]3COC)ccc21 CHEMBL493926 IC50 58.0 nM
O=C(CCc1ccc(F)cc1)n1sc2ccccc2c1=O CHEMBL3360051 IC50 59.7 nM
C#CCN1C(=O)C(=O)c2cc(S(=O)(=O)N3CCC[C@H]3COc3ccc(F)cc3F)ccc21 CHEMBL515661 EC50 60.4 nM
COC[C@@H]1CCCN1S(=O)(=O)c1ccc2c(c1)C(=O)C(=O)N2CCCCCCCCCC1CO1 CHEMBL521984 IC50 61.0 nM
COC[C@@H]1CCCN1S(=O)(=O)c1ccc2c(c1)C(=O)C(=O)N2CCC(O)CO CHEMBL466423 IC50 61.0 nM
COc1ccc(-c2nc(C)no2)cc1[C@@H](O)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)CSCc1ccccc1)C(C)C CHEMBL361111 IC50 63.0 nM
CC(=O)OC(C(=O)Nc1cccc2c1C(=O)C(=O)NC2=O)c1ccccc1 CHEMBL439872 IC50 63.0 nM
COc1ccccc1CCC(=O)n1sc2ccccc2c1=O CHEMBL3360046 IC50 63.7 nM
O=C(CCC(=O)N1CCCCC1)Nc1ccc2c(c1)C(=O)C(=O)NC2=O CHEMBL438969 IC50 64.0 nM
CN1CCN(c2ccc(NC(=O)n3sc4ccccc4c3=O)cc2)CC1 CHEMBL3233633 IC50 64.44 nM
CCCCN1C(=O)C(=O)c2cc(S(=O)(=O)N3CCC[C@H]3COCC)ccc21 CHEMBL2348698 IC50 64.6 nM
CCCCCCN(C)CC(=O)[C@H](CC(=O)O)NC(=O)C(CC)n1cc(C(C)(C)C)nc(Nc2nnn[nH]2)c1=O CHEMBL248310 IC50 64.7 nM
CCCCCCN(C)CNCC(=O)[C@H](CC(=O)O)NC(=O)C(CC)n1cc(C(C)C)nc(NCc2nonc2C)c1=O CHEMBL180646 IC50 65.0 nM
COC[C@@H]1CCCN1S(=O)(=O)c1ccc2c(c1)C(=O)C(=O)N2CCC1CO1 CHEMBL493374 IC50 68.0 nM
COC[C@@H]1CCCN1S(=O)(=O)c1cc(I)c2c(c1)C(=O)C(=O)N2CCCCF CHEMBL3359188 IC50 68.1 nM
N#CC(C#N)=C1C(=O)N(Cc2ccc(OCCOCCF)cc2)c2ccc(S(=O)(=O)N3CC[C@H]3COc3ccccc3)cc21 CHEMBL1762355 IC50 68.3 nM
COC[C@@H]1CCCN1S(=O)(=O)c1ccc2c(c1)C(=O)C(=O)N2Cc1ccc(O[Si](C)(C)C(C)(C)C)cc1 CHEMBL387041 IC50 69.8 nM
N#CC(C#N)=C1C(=O)N(Cc2ccc(OCCOCCF)cc2)c2ccc(S(=O)(=O)N3CCC[C@H]3COc3ccccc3)cc21 CHEMBL1762359 IC50 70.0 nM
COC[C@@H]1CCCN1S(=O)(=O)c1ccc2c(c1)C(=O)C(=O)N2CC[C@@H](F)CO CHEMBL2381346 IC50 71.0 nM
O=C(Nc1ccc(N2CCCCC2)cc1)n1sc2ccccc2c1=O CHEMBL3233634 IC50 72.2 nM
Cc1ccc(CCC(=O)n2sc3ccccc3c2=O)cc1 CHEMBL3360045 IC50 72.5 nM
O=C(CCc1ccc(Cl)cc1)n1sc2ccccc2c1=O CHEMBL3360053 IC50 72.7 nM
COc1ccc(CCCC(=O)n2sc3ccccc3c2=O)cc1 CHEMBL3360056 IC50 74.9 nM
CN1CCN(c2cccc(NC(=O)n3sc4ccccc4c3=O)c2)CC1 CHEMBL3233632 IC50 75.82 nM
O=C(CCc1cccc(F)c1)n1sc2ccccc2c1=O CHEMBL3360050 IC50 78.4 nM
O=C1C(=O)N(Cc2ccc(F)cc2)c2ccc(S(=O)(=O)N3CCCC3)cc21 CHEMBL461248 EC50 78.6 nM
COC[C@@H]1CCCN1S(=O)(=O)c1ccc2c(c1)C(=O)C(=O)N2CCCCl CHEMBL493927 IC50 79.0 nM
CCC(C(=O)N[C@@H](CC(=O)O)C(=O)CNCN1CCc2ccccc2C1)n1ccnc(NCc2nonc2C)c1=O CHEMBL360788 IC50 83.0 nM
O=C(CCc1ccccc1F)n1sc2ccccc2c1=O CHEMBL3360049 IC50 86.9 nM
CCCCCCN(C)CNCC(=O)[C@H](CC(=O)O)NC(=O)C(CC)n1cc(C(C)(CC)CC)nc(NCc2nonc2C)c1=O CHEMBL362074 IC50 87.0 nM
O=C(O)C[C@H](NC(=O)c1ccc(CNS(=O)(=O)c2ccc(O)c(C(=O)O)c2)nc1)C(=O)CSc1ccccc1Cl CHEMBL147775 Ki 90.0 nM
O=C(O)C[C@H](NC(=O)c1cnc(CNS(=O)(=O)c2ccc(O)c(C(=O)O)c2)s1)C(=O)CSCc1ccccc1Cl CHEMBL435284 Ki 90.0 nM
O=C(O)C[C@H](NC(=O)c1cnc(CNS(=O)(=O)c2ccc(O)c(C(=O)O)c2)nc1)C(=O)CSCc1ccccc1Cl CHEMBL149307 Ki 90.0 nM
CCCCCN(C)CC(=O)C(CC(=O)O)NC(=O)C(CC)n1cc(C(C)(C)C)nc(NCc2nonc2C)c1=O CHEMBL179503 IC50 90.0 nM
COc1ccc(Br)cc1[C@@H](O)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)CSCc1ccccc1)C(C)C CHEMBL183379 IC50 91.0 nM
N#CC(C#N)=C1C(=O)N(Cc2ccc(Br)cc2)c2ccc(S(=O)(=O)N3CCC[C@H]3COc3ccccc3)cc21 CHEMBL436989 IC50 92.2 nM
CN1C(=O)C(=O)c2cc(S(=O)(=O)N3CCC[C@H]3COc3cccnc3)ccc21 CHEMBL371879 IC50 94.9 nM
O=C(Nc1ccc(C2OCCO2)cc1)n1sc2ccccc2c1=O CHEMBL3233638 IC50 94.98 nM
N#CC(C#N)=C1C(=O)N(Cc2ccc(OCCF)cc2)c2ccc(S(=O)(=O)N3CCC[C@H]3COc3ccccc3)cc21 CHEMBL1762358 IC50 96.3 nM
COc1ccc(-c2nc(C)no2)cc1CC(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)CSCc1ccccc1)C(C)C CHEMBL360880 IC50 97.0 nM
Cc1ccc(CCCC(=O)n2sc3ccccc3c2=O)cc1 CHEMBL3360055 IC50 97.9 nM
COC[C@@H]1CCCN1S(=O)(=O)c1ccc2c(c1)C(=O)C(=O)N2CCC(O)CF CHEMBL493375 IC50 99.0 nM
CCCCCCCCN(C)CNCC(=O)[C@H](CC(=O)O)NC(=O)C(CC)n1ccnc(NCc2nonc2C)c1=O CHEMBL178514 IC50 100.0 nM
COC[C@@H]1CCCN1S(=O)(=O)c1ccc2c(c1)C(=O)C(=O)N2CCCC(F)(F)F CHEMBL475040 IC50 100.0 nM
O=C(CCCCc1ccccc1)n1sc2ccccc2c1=O CHEMBL3360057 IC50 100.9 nM
COC[C@@H]1CCCN1S(=O)(=O)c1ccc2c(c1)C(=O)C(=O)N2CC[C@H](O)CO CHEMBL2381344 IC50 103.0 nM
Cc1cccc(CCC(=O)n2sc3ccccc3c2=O)c1 CHEMBL3360044 IC50 109.0 nM
CCCCCN(C)CNCC(=O)[C@H](CC(=O)O)NC(=O)C(CC)n1ccnc(NCc2nonc2C)c1=O CHEMBL181623 IC50 110.0 nM
COC[C@@H]1CCCN1S(=O)(=O)c1ccc2c(c1)C(=O)C(=O)N2CCCCCCCCCCC(F)F CHEMBL483408 IC50 111.0 nM
C=CCCCCCCCCCN1C(=O)C(=O)c2cc(S(=O)(=O)N3CCC[C@H]3COC)ccc21 CHEMBL513513 IC50 111.0 nM
O=C(CCc1ccccc1)n1sc2ccccc2c1=O CHEMBL3360043 IC50 111.9 nM
O=C(Cc1ccc(-c2ccccc2)cc1)n1sc2ccccc2c1=O CHEMBL3360061 IC50 115.0 nM
O=C(CCCc1cccs1)n1sc2ccccc2c1=O CHEMBL3360060 IC50 115.1 nM
O=C[C@H](CC(=O)O)NC(=O)c1ccc(CNS(=O)(=O)c2ccc(O)c(C(=O)O)c2)s1 CHEMBL147642 Ki 120.0 nM
COc1ccc(S(C)(=O)=O)cc1CC(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)CSCc1c(F)cccc1Cl)C(C)C CHEMBL166754 IC50 120.0 nM
COc1ccc(S(C)(=O)=O)cc1CC(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)CSCc1ccccc1)C(C)C CHEMBL425699 IC50 120.0 nM
COC[C@@H]1CCCN1S(=O)(=O)c1ccc2c(c1)C(=O)C(=O)N2CC(O)CCl CHEMBL515299 IC50 123.0 nM
O=C(Cc1ccccc1F)n1sc2ccccc2c1=O CHEMBL3360035 IC50 123.0 nM
COC[C@@H]1CCCN1S(=O)(=O)c1cc(I)c2c(c1)C(=O)C(=O)N2CCCF CHEMBL3359187 IC50 123.0 nM
COCCCC1CCCN1S(=O)(=O)c1ccc2c(c1)C(=O)C(=O)N2 CHEMBL2348694 IC50 125.0 nM
C=CCn1c(=N)c(C(=O)OC)cc2c(=O)n3cccc(C)c3nc21 CHEMBL1557078 Potency 125.9 nM
N#CC(C#N)=C1C(=O)N(Cc2ccc(O)cc2)c2ccc(S(=O)(=O)N3CCC[C@H]3COc3ccccc3)cc21 CHEMBL427283 IC50 126.0 nM
COC[C@@H]1CCCN1S(=O)(=O)c1ccc2c(c1)C(=O)C(=O)N2CC[C@@H](O)CO CHEMBL2381349 IC50 128.0 nM
COC[C@@H]1CCCN1S(=O)(=O)c1ccc2c(c1)C(=O)C(=O)N2CCC(=O)O CHEMBL492322 IC50 129.0 nM
CC(C)CC(NC(=O)[C@H](CCC(=O)O)Oc1cccc2ccccc12)C(=O)N[C@H]1CC(=O)OC1O CHEMBL101545 IC50 130.0 nM
O=C(O)C[C@H](NC(=O)c1ccc(CNS(=O)(=O)c2ccc(O)c(C(=O)O)c2)s1)C(=O)CSCc1ccccc1Cl CHEMBL146453 Ki 130.0 nM
O=C[C@H](CC(=O)O)NC(=O)c1ccc(CNS(=O)(=O)c2ccc(O)c(C(=O)O)c2)nc1 CHEMBL358725 Ki 130.0 nM
COc1ccc(C(C)=O)cc1CC(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)CSCc1ccccc1)C(C)C CHEMBL167071 IC50 130.0 nM
CCC(C(=O)N[C@@H](CC(=O)O)C(=O)CNCN1Cc2ccccc2C1)n1ccnc(NCc2nonc2C)c1=O CHEMBL367356 IC50 130.0 nM
CCC(C(=O)N[C@@H](CC(=O)O)C(=O)CNCN1CCCCC1)n1cc(C(C)(C)C)nc(NCc2nonc2C)c1=O CHEMBL434147 IC50 130.0 nM
CCCCN(C)CNCC(=O)[C@H](CC(=O)O)NC(=O)C(CC)n1ccnc(NCc2nonc2C)c1=O CHEMBL179551 IC50 130.0 nM
O=C1C(=O)N(Cc2ccccc2)c2ccc(S(=O)(=O)N3CCC3)cc21 CHEMBL476022 IC50 132.0 nM
COc1ccc(I)cc1[C@@H](O)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)CSCc1ccccc1)C(C)C CHEMBL183619 IC50 135.0 nM
O=C1C(=O)N(Cc2ccnc(F)c2)c2ccc(S(=O)(=O)N3CC[C@H]3COc3ccccc3)cc21 CHEMBL196855 IC50 135.0 nM
COC[C@@H]1CCCN1S(=O)(=O)c1ccc2c(c1)C(=O)C(=O)N2Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 CHEMBL493127 IC50 135.0 nM
CCN1C(=O)C(=O)c2cc(S(=O)(=O)N3CCC[C@H]3COC)cc(Br)c21 CHEMBL3359192 IC50 135.0 nM
O=C(O)CCC(=O)Nc1ccc2c(c1)C(=O)C(=O)NC2=O CHEMBL202971 IC50 136.0 nM
C#CC[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)CSCc1ccccc1)C(C)C)c1cc(Br)ccc1OC CHEMBL183109 IC50 139.0 nM
O=C(CCCl)Nc1ccc2c(c1)C(=O)C(=O)NC2=O CHEMBL382481 IC50 139.0 nM
CCC(C(=O)N[C@@H](CC(=O)O)C(=O)CCCc1ccccc1)n1cc(C(C)(C)C)nc(NCc2nonc2C)c1=O CHEMBL180623 IC50 140.0 nM
CCCCCCN(C)CNCC(=O)[C@H](CC(=O)O)NC(=O)C(CC)n1ccnc(NCc2nonc2C)c1=O CHEMBL359598 IC50 140.0 nM
O=C1Nc2ccc(S(=O)(=O)N3CCC[C@H]3COc3ccncc3)cc2C1=O CHEMBL197237 IC50 142.3 nM
O=C(Cc1ccccc1Cl)n1sc2ccccc2c1=O CHEMBL3360038 IC50 144.9 nM
CCOC(=O)/C=C/[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)OCc1ccccc1)c1ccccc1)C(C)C CHEMBL2324341 IC50 150.0 nM
O=C(Nc1ccc(-c2ccccn2)cc1)n1sc2ccccc2c1=O CHEMBL3233635 IC50 156.1 nM
O=C(c1ccccc1)c1ccc(NC(=O)n2sc3ccccc3c2=O)cc1 CHEMBL3233640 IC50 156.7 nM
CCCN1C(=O)C(=O)c2cc(S(=O)(=O)N3CCC[C@H]3COC)cc(Br)c21 CHEMBL3359193 IC50 157.0 nM
O=C(CCc1ccccc1Cl)n1sc2ccccc2c1=O CHEMBL3360052 IC50 158.2 nM
CCN(CC)c1ccc2cc(-c3nc4ccccc4[nH]3)c(=O)oc2c1 CHEMBL374632 Potency 158.5 nM
O=C(Nc1ccc(N2CCOCC2)cc1)n1sc2ccccc2c1=O CHEMBL3233630 IC50 164.0 nM
O=C(CCCc1ccccc1)n1sc2ccccc2c1=O CHEMBL3360054 IC50 166.3 nM
O=C1C(=O)N(Cc2ccccc2)c2ccc([N+](=O)[O-])cc21 CHEMBL60306 Ki app 170.0 nM
COC[C@@H]1CCCN1S(=O)(=O)c1ccc2c(c1)C(=O)C(=O)N2 CHEMBL60190 Ki app 170.0 nM
COC[C@@H]1CCCN1S(=O)(=O)c1ccc2c(c1)C(=O)C(=O)N2CCC(F)=C(F)F CHEMBL493123 IC50 178.0 nM
CCCCN1C(=O)C(=O)c2cc(S(=O)(=O)N3CC(F)(F)C[C@H]3COC)ccc21 CHEMBL2391975 IC50 178.0 nM
Cc1ccc(CC(=O)n2sc3ccccc3c2=O)cc1 CHEMBL3360031 IC50 182.3 nM
Cc1cccc(CC(=O)n2sc3ccccc3c2=O)c1 CHEMBL3360030 IC50 184.0 nM
O=C(Cc1ccc2c(c1)CCO2)n1sc2ccccc2c1=O CHEMBL3360063 IC50 185.1 nM
CN(Cc1ccc(O)c(C(=O)O)c1)Cc1ccc(C(=O)N[C@@H](CC(=O)O)C(=O)CSCc2ccccc2Cl)s1 CHEMBL357191 Ki 190.0 nM
CN1CCN(S(=O)(=O)c2ccc(NC(=O)n3sc4ccccc4c3=O)cc2)CC1 CHEMBL3233642 IC50 193.9 nM
O=C(Cc1ccc(Cl)c(Cl)c1)n1sc2ccccc2c1=O CHEMBL3360042 IC50 198.3 nM
CC(C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)OCc1ccccc1)C1Cc2ccccc2C1)C(=O)N[C@H](/C=C/S(C)(=O)=O)CC(=O)O CHEMBL3673264 IC50 200.0 nM
COc1ccccc1CC(=O)n1sc2ccccc2c1=O CHEMBL3360032 IC50 207.2 nM
COc1cccc(CC(=O)n2sc3ccccc3c2=O)c1 CHEMBL3360033 IC50 211.2 nM
COc1ccc(CC(=O)n2sc3ccccc3c2=O)cc1 CHEMBL3360034 IC50 213.3 nM
O=C1Nc2ccc(S(=O)(=O)N3CCC[C@H]3COc3cccnc3)cc2C1=O CHEMBL197535 IC50 214.9 nM
COC[C@@H]1CCCN1S(=O)(=O)c1ccc2c(c1)C(=O)C(=O)N2CCCOS(C)(=O)=O CHEMBL492718 IC50 217.0 nM
COc1ccccc1NC(=O)CCC(=O)Nc1ccc2c(c1)C(=O)C(=O)NC2=O CHEMBL203709 IC50 218.0 nM
CCOC[C@@H]1CCCN1S(=O)(=O)c1ccc2c(c1)C(=O)C(=O)N2CCCCF CHEMBL2348699 IC50 218.0 nM
N#CC(C#N)=C1C(=O)N(Cc2ccccc2)c2ccc(S(=O)(=O)N3CCC3)cc21 CHEMBL516251 IC50 248.0 nM
CCC(C(=O)N[C@@H](CC(=O)O)C(=O)CNCN1C2CCC1CC2)n1ccnc(NCc2nonc2C)c1=O CHEMBL178674 IC50 260.0 nM
CCCCN1C(=O)C(=O)c2cc(S(=O)(=O)N3CCC[C@H]3COC)cc(Cl)c21 CHEMBL3359199 IC50 263.0 nM
O=C1C(=O)N(CCCCF)c2ccc(S(=O)(=O)N3CCC[C@H]3COCC(F)(F)F)cc21 CHEMBL2348861 IC50 265.0 nM
C=C(F)CN1C(=O)C(=O)c2cc(S(=O)(=O)N3CCC[C@H]3COC)ccc21 CHEMBL524194 IC50 266.0 nM
CC(C)C[C@H](NC(=O)C(=O)Nc1cccc2ccccc12)C(=O)N[C@@H](CC(=O)O)C(=O)O CHEMBL3940506 IC50 267.0 nM
O=C(Cc1ccccc1)n1sc2ccccc2c1=O CHEMBL3360028 IC50 268.7 nM
COC[C@@H]1CCCN1S(=O)(=O)c1cc(I)c2c(c1)C(=O)C(=O)N2CCCCO CHEMBL3359189 IC50 279.0 nM
CCC(C(=O)N[C@@H](CC(=O)O)C(=O)CCCc1ccccc1)n1cc(C(C)(C)C)nc(Nc2ccc3c(c2)OCCO3)c1=O CHEMBL248309 IC50 280.0 nM
COc1ccc(Br)cc1CC(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)CSCc1ccccc1)C(C)C CHEMBL82932 IC50 284.0 nM
CN1C(=O)C(=O)c2cc([N+](=O)[O-])ccc21 CHEMBL293622 Ki app 290.0 nM
COc1ccc(C(C)=O)cc1[C@@H](O)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)CSCc1ccccc1)C(C)C CHEMBL360046 IC50 290.0 nM
N#CC(C#N)=C1C(=O)N(Cc2ccc(OCCF)cc2)c2ccc(S(=O)(=O)N3CC[C@H]3COc3ccccc3)cc21 CHEMBL1762354 IC50 292.0 nM
COC[C@@H]1CCCN1S(=O)(=O)c1ccc2c(c1)C(=O)C(=O)N2CC[C@@H](O)CF CHEMBL2381348 IC50 296.0 nM
O=C(Cc1ccc2ccccc2c1)n1sc2ccccc2c1=O CHEMBL3360062 IC50 296.7 nM
COC[C@@H]1CCCN1S(=O)(=O)c1ccc2c(c1)C(=O)C(=O)N2C CHEMBL216819 IC50 304.0 nM
CCC(C(=O)N[C@@H](CC(=O)O)C(=O)CNCN(C)C)n1ccnc(NCc2nonc2C)c1=O CHEMBL181027 IC50 310.0 nM
CCN1C(=O)C(=O)c2cc(S(=O)(=O)N3CCC[C@H]3COC)ccc21 CHEMBL521839 IC50 319.0 nM
CCCN(C)CNCC(=O)[C@H](CC(=O)O)NC(=O)C(CC)n1ccnc(NCc2nonc2C)c1=O CHEMBL181763 IC50 320.0 nM
O=C(Cc1ccc(O)cc1)n1sc2ccccc2c1=O CHEMBL3360041 IC50 330.1 nM
N#CC(C#N)=C1C(=O)N(Cc2ccc(Cl)c(Cl)c2)c2ccc(S(=O)(=O)N3CCC3)cc21 CHEMBL510809 IC50 340.0 nM
COC[C@@H]1CCCN1S(=O)(=O)c1ccc2c(c1)C(=O)C(=O)N2C[C@H](O)CF CHEMBL524017 IC50 349.0 nM
CCOc1ccc(OCC(=O)O)cc1CC(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)CSCc1c(F)cccc1Cl)C(C)C CHEMBL167882 IC50 360.0 nM
CN1C(=O)C(=O)c2cc(S(=O)(=O)N3CC[C@H]3COc3ccccc3)ccc21 CHEMBL371709 IC50 362.5 nM
CC(C)(C)[Si](C)(C)Oc1ccc(CN2C(=O)C(=O)c3cc(S(=O)(=O)N4CCC[C@H]4COc4ccccc4)ccc32)cc1 CHEMBL217821 IC50 366.0 nM
Cc1ccccc1CC(=O)n1sc2ccccc2c1=O CHEMBL3360029 IC50 370.3 nM
Cn1nc(-c2ccccn2)nc2c(=O)n(C)c(=O)nc1-2 CHEMBL1463659 AC50 371.0 nM
O=C1NC(=O)c2ccccc2C1=O CHEMBL206435 IC50 386.0 nM
O=C(Nc1ccccc1N1CCOCC1)n1sc2ccccc2c1=O CHEMBL3233628 IC50 390.2 nM
Cn1c(=O)c(-c2cccs2)nc2cnc(N3CCOCC3)nc21 CHEMBL1477247 Potency 398.1 nM
CC(C)[C@H](NC(=O)[C@H](Cc1ccc2ccccc2n1)NC(=O)[C@H](CC(=O)O)NC(=O)OCc1ccccc1)C(=O)N[C@H](/C=C/S(=O)(=O)Oc1ccccc1)CC(=O)O CHEMBL3673267 IC50 400.0 nM
CC(C)[C@H](NC(=O)[C@H](Cc1ccc2ccccc2n1)NC(=O)[C@H](CC(=O)O)NC(=O)OCc1ccccc1)C(=O)N[C@H](/C=C(\Cl)S(C)(=O)=O)CC(=O)O CHEMBL3673259 IC50 400.0 nM
CCC(C(=O)N[C@@H](CC(=O)O)C(=O)CNCN1CCCC1)n1ccnc(NCc2nonc2C)c1=O CHEMBL424789 IC50 410.0 nM
O=C(NCc1ccco1)n1sc2ccccc2c1=O CHEMBL3233625 IC50 418.7 nM
COc1ccc(CN2C(=O)C(=C(C#N)C#N)c3cc(S(=O)(=O)N4CCCC4)ccc32)cc1 CHEMBL477659 IC50 443.0 nM
O=C(Cc1cccc(F)c1)n1sc2ccccc2c1=O CHEMBL3360036 IC50 457.7 nM
O=C[C@H](CC(=O)O)NC(=O)c1ccc(CNS(=O)(=O)c2ccc(O)c(C(=O)O)c2)cc1 CHEMBL422849 Ki 470.0 nM
COc1ccc(CN2C(=O)C(=C(C#N)C#N)c3cc(S(=O)(=O)N4CCC4)ccc32)cc1 CHEMBL476023 IC50 471.0 nM
N#CC(C#N)=C1C(=O)N(Cc2ccc(Cl)c(Cl)c2)c2ccc(S(=O)(=O)N3CCCC3)cc21 CHEMBL478694 IC50 471.0 nM
CCC(C(=O)N[C@@H](CC(=O)O)C(C)=O)n1cc(C(C)(C)C)nc(NCc2nonc2C)c1=O CHEMBL178339 IC50 480.0 nM
CCC(C(=O)N[C@@H](CC(=O)O)C(=O)CSCc1ccccc1)n1ccnc(NCc2cncs2)c1=O CHEMBL180273 IC50 490.0 nM
CC(C)(C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)OCc1ccccc1)C(=O)N1CC[C@H]1C(=O)N[C@H](/C=C/S(C)(=O)=O)CC(=O)O CHEMBL2323967 IC50 500.0 nM
CC(C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)OCc1ccccc1)c1ccccc1)C(=O)N[C@H](/C=C(\Cl)S(C)(=O)=O)CC(=O)O CHEMBL3678074 IC50 500.0 nM
CCNc1ncc2nc(-c3cccs3)c(=O)n(C)c2n1 CHEMBL1316796 Potency 501.2 nM
O=c1c(-c2cc(F)cc(F)c2)nc2cnc(N3CCOCC3)nc2n1C[C@H]1CCCO1 CHEMBL1512835 Potency 501.2 nM
CCNc1ncc2nc(-c3ccc(F)cc3)c(=O)n(CCC#N)c2n1 CHEMBL1317306 Potency 501.2 nM
Cc1ccc(-n2c(=O)c(C#N)cc3c(=O)n4ccccc4nc32)cc1 CHEMBL1583049 Potency 501.2 nM
COc1cccc(Cn2c(=O)c(-c3ccc(F)cc3)nc3cnc(N4CCOCC4)nc32)c1 CHEMBL1484120 Potency 501.2 nM
Cc1cc2c(C(F)(F)F)cc(=O)oc2c2c1NCCC2 CHEMBL1585011 Potency 501.2 nM
CCCCN1C(=O)C(=O)c2cc(S(=O)(=O)N3CCCC3CCCOC)ccc21 CHEMBL2348695 IC50 515.0 nM
CCC(C(=O)N[C@@H](CC(=O)O)C(=O)CNCN1CCOCC1)n1cc(C(C)(C)C)nc(NCc2nonc2C)c1=O CHEMBL178775 IC50 540.0 nM
CCC(C(=O)N[C@@H](CC(=O)O)C(=O)CNCN(C)CC)n1ccnc(NCc2nonc2C)c1=O CHEMBL264344 IC50 540.0 nM
COCC[C@@H]1CCCN1S(=O)(=O)c1ccc2c(c1)C(=O)C(=O)N2 CHEMBL2348691 IC50 540.0 nM
COc1ccc(OC)c([C@@H](O)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)CSCc2ccccc2)C(C)C)c1 CHEMBL360690 IC50 545.0 nM
COC[C@@H]1CCCN1S(=O)(=O)c1cc(Br)c2c(c1)C(=O)C(=O)N2C CHEMBL3359191 IC50 553.0 nM
O=C(Cc1ccc(Cl)cc1)n1sc2ccccc2c1=O CHEMBL3360040 IC50 585.6 nM
CC(C)CC(NC(=O)[C@@H](CCC(=O)O)Oc1cccc2ccccc12)C(=O)N[C@H]1CC(=O)OC1O CHEMBL100643 IC50 587.0 nM
N#CC(C#N)=C1C(=O)N(Cc2ccccc2)c2ccc(S(=O)(=O)N3CCCC3)cc21 CHEMBL477047 IC50 587.0 nM
CCCCCCN(C)CNCC(=O)[C@H](CC(=O)O)NC(=O)C(CC)n1cc(CC)nc(NCc2nonc2C)c1=O CHEMBL369290 IC50 600.0 nM
O=C(Cc1cccc(Cl)c1)n1sc2ccccc2c1=O CHEMBL3360039 IC50 607.1 nM
O=C(Cc1ccc(F)cc1)n1sc2ccccc2c1=O CHEMBL3360037 IC50 608.1 nM
COc1cccc(Cn2c(=O)c(-c3cc(F)cc(F)c3)nc3cnc(N4CCOCC4)nc32)c1 CHEMBL1479202 Potency 631.0 nM
Cn1cc(-c2nc3cncnc3n(Cc3ccccc3Cl)c2=O)c2ccccc21 CHEMBL1315109 Potency 631.0 nM
Cc1ccc2nc3c(cc(C#N)c(=N)n3CC3CCCO3)c(=O)n2c1 CHEMBL1486599 Potency 631.0 nM
COc1cccc(Cn2c(=O)c(-c3ccc(Cl)cc3)nc3cnc(N(C)C)nc32)c1 CHEMBL1476021 Potency 631.0 nM
CCNc1ncc2nc(-c3cccs3)c(=O)n(C[C@H]3CCCO3)c2n1 CHEMBL1482759 Potency 631.0 nM
COc1cccc(Cn2c(=O)c(-c3ccc(Cl)cc3)nc3cnc(N4CCOCC4)nc32)c1 CHEMBL1435248 Potency 631.0 nM
CCn1nc(-c2cccs2)nc2c(=O)n(C)c(=O)nc1-2 CHEMBL555689 Potency 631.0 nM
CN1CCN(c2ccccc2NC(=O)n2sc3ccccc3c2=O)CC1 CHEMBL3233631 IC50 637.9 nM
CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1)C(=O)N[C@H]1CC(=O)OC1O CHEMBL101835 IC50 680.0 nM
CC(C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)OCc1ccccc1)C(=O)N[C@H](/C=C/S(C)(=O)=O)CC(=O)O CHEMBL3678066 IC50 700.0 nM
CCC(C(=O)N[C@@H](CC(=O)O)C(=O)CSCc1ccccc1)n1ccnc(NCc2nonc2C)c1=O CHEMBL433771 IC50 730.0 nM
CCC(C(=O)N[C@@H](CC(=O)O)C(=O)c1ncc(-c2ccccc2)o1)n1ccnc(NCc2nonc2C)c1=O CHEMBL179066 IC50 750.0 nM
CN1C(=O)C(=C(C#N)C#N)c2cc(S(=O)(=O)N3CCC[C@H]3COc3ccccc3)ccc21 CHEMBL390932 IC50 785.0 nM
CCNc1ncc2nc(-c3cn(C)c4ccccc34)c(=O)n(Cc3cccc(OC)c3)c2n1 CHEMBL1369824 Potency 794.3 nM
CN(C)c1ncc2nc(-c3cccc(C#N)c3)c(=O)n(C[C@H]3CCCO3)c2n1 CHEMBL1517643 Potency 794.3 nM
Cn1cc(-c2nc3cnc(N4CCOCC4)nc3n(C3CC3)c2=O)c2ccccc21 CHEMBL1371458 Potency 794.3 nM
CN(C)c1ncc2nc(-c3cccs3)c(=O)n(Cc3cccs3)c2n1 CHEMBL1595910 Potency 794.3 nM
COCCn1c(=O)c(-c2cn(C)c3ccccc23)nc2cnc(OCc3ccccc3)nc21 CHEMBL1592580 Potency 794.3 nM
COc1cccc(Cn2c(=O)c(-c3ccccc3)nc3cnc(N(C)C)nc32)c1 CHEMBL1440650 Potency 794.3 nM
CCNc1ncc2nc(-c3cc(F)cc(F)c3)c(=O)n(CCC#N)c2n1 CHEMBL1315129 Potency 794.3 nM
COc1ccc(-c2nc3cnc(Nc4ccccc4)nc3n(Cc3cccs3)c2=O)cc1 CHEMBL1491965 Potency 794.3 nM
CN(C)c1ncc2nc(-c3ccc(F)cc3)c(=O)n(Cc3ccc(F)cc3)c2n1 CHEMBL1397151 Potency 794.3 nM
O=c1c(-c2cccs2)nc2cnc(N3CCOCC3)nc2n1Cc1ccc(F)cc1 CHEMBL1358654 Potency 794.3 nM
CC(=O)Oc1ccc2cc(-c3nc4ccccc4n3C)c(=O)oc2c1 CHEMBL1503105 Potency 794.3 nM
O=c1oc2c(CN3CCCCC3)c(O)ccc2cc1-c1nc2ccccc2[nH]1 CHEMBL1572146 Potency 794.3 nM
N#Cc1c(NCCCO)nc(NCc2ccccc2)c2c1CCN(Cc1ccccc1)C2 CHEMBL1348071 Potency 794.3 nM
COc1ccc(-c2nc3cnc(N(C)C)nc3n(C[C@H]3CCCO3)c2=O)cc1 CHEMBL1612620 Potency 794.3 nM
O=c1c(-c2ccc(F)cc2)nc2cnc(N3CCOCC3)nc2n1Cc1ccc(F)cc1 CHEMBL1315965 Potency 794.3 nM
CCC(C(=O)N[C@@H](CC(=O)O)C(=O)CCCc1ccccc1)n1cc(C(C)(C)C)nc(NCc2cc(OC)cc(OC)c2)c1=O CHEMBL246887 IC50 800.0 nM
CC(C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)OCc1ccccc1)c1ccccc1)C(=O)N[C@H](/C=C/S(C)(=O)=O)CC(=O)O CHEMBL3673262 IC50 800.0 nM
CCC(C(=O)N[C@@H](CC(=O)O)C(=O)CSCc1ccccc1)n1ccnc(NCc2cccs2)c1=O CHEMBL361613 IC50 810.0 nM
CCC(C(=O)N[C@@H](CC(=O)O)C(=O)CNCN1CCC(Cc2ccccc2)CC1)n1ccnc(NCc2nonc2C)c1=O CHEMBL441118 IC50 840.0 nM
N#CC(C#N)=C1C(=O)N(Cc2ccccc2)c2ccc(S(=O)(=O)N3CCCCC3)cc21 CHEMBL519148 IC50 878.0 nM
CCn1nc(-c2ccccc2)nc2c(=O)n(C)c(=O)nc1-2 CHEMBL1488035 Potency 891.3 nM
CCN(CC)CCCC(C)n1c2nc(=O)[nH]c(=O)c-2nc2cc(Cl)ccc21 CHEMBL1709883 AC50 899.0 nM
CCCCN1C(=O)C(=O)c2cc(S(=O)(=O)N3CCC[C@H]3COC)cc(I)c21 CHEMBL3359186 IC50 907.0 nM
CCC(C(=O)N[C@@H](CC(=O)O)C(=O)CCCc1ccccc1)n1cc(C(C)(C)C)nc(NCCc2cccs2)c1=O CHEMBL392245 IC50 920.0 nM
Cc1cc(CNS(=O)(=O)c2ccc(O)c(C(=O)O)c2)sc1C(=O)N[C@@H](CC(=O)O)C(=O)CSCc1ccccc1Cl CHEMBL148162 Ki 940.0 nM