O=C(O)c1ccccc1Nc1nc(Nc2ccccc2)ncc1F CHEMBL244793 pKi 0.1259 nM
COc1ccc(Nc2nccc(Nc3ccccc3C(=O)O)n2)cc1O CHEMBL1964519 pKi 0.1259 nM
OC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1986943 pKi 0.1585 nM
CNC(=O)NC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL2005509 pKi 0.1585 nM
O[C@H]1CC[C@H](Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL2062936 pKi 0.1585 nM
NC(=O)c1cc(-c2ccnc(N)n2)[nH]c1-c1ccc(Cl)cc1Cl CHEMBL1965660 pKi 0.1995 nM
CCNC(=O)NC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1992220 pKi 0.1995 nM
CS(=O)(=O)NC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1980562 pKi 0.2512 nM
O=c1cc(-c2c[nH]c3ncccc23)cc(NC2CCCCC2)[nH]1 CHEMBL1958408 Ki 0.28 nM
Clc1cc(-c2c[nH]c3ncccc23)nc(NC2CCOCC2)n1 CHEMBL1980253 pKi 0.3162 nM
CNCC(=O)NC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1996980 pKi 0.3162 nM
CN(C)C1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1969151 pKi 0.3162 nM
NC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1973720 pKi 0.3162 nM
CN(C)c1ccc(C(=O)Nc2n[nH]c3ccc(-c4cn(Cc5ccccc5)nn4)cc23)cc1 CHEMBL1992363 pKi 0.3162 nM
CN(C)CC(=O)NC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1982271 pKi 0.3162 nM
CN(C)[C@H]1CC[C@H](Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL2062937 pKi 0.3162 nM
NC(=O)c1cc(-c2ccnc(N)n2)[nH]c1-c1ccc(Cl)cc1F CHEMBL1981079 pKi 0.3981 nM
Cc1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3-c3ccc(F)cc3)cc12 CHEMBL1972339 pKi 0.3981 nM
CN(C)c1ccc(-c2c(-c3ccc4[nH]nc(N)c4c3)nnn2Cc2ccccc2)cc1 CHEMBL1969221 pKi 0.3981 nM
COc1cc(OC)cc(C(=O)Nc2n[nH]c3ccc(-c4cn(Cc5ccccc5)nn4)cc23)c1 CHEMBL2002613 pKi 0.3981 nM
O=C(O)c1ccccc1Nc1ncnc(Nc2cccc(F)c2)n1 CHEMBL1979933 pKi 0.3981 nM
CS(=O)(=O)NC1CCC(Nc2cc(Cl)nc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL2005216 pKi 0.3981 nM
O=C(Nc1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12)c1ccccc1 CHEMBL1999931 Ki 0.4 nM
Cc1n[nH]cc1-c1cc2nc([C@@H]3CC4CCN3CC4)[nH]c(=O)c2s1 CHEMBL4297644 Kd 0.424 nM
O=C(Nc1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12)c1cccc(F)c1 CHEMBL2003638 Ki 0.5 nM
Nc1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3-c3cccs3)cc12 CHEMBL3890525 Ki 0.5 nM
CCCCC(=O)Nc1cc(-c2c[nH]c3ncccc23)cc(Cl)n1 CHEMBL2006450 pKi 0.5012 nM
Clc1cc(-c2c[nH]c3ncccc23)nc(NC2CCCCC2)n1 CHEMBL2006439 pKi 0.5012 nM
Cc1n[nH]cc1-c1cc2nc(CN3CCCC3)[nH]c(=O)c2s1 CHEMBL4083927 Kd 0.541 nM
c1ccc(Cn2nnc(-c3ccc4[nH]ncc4c3)c2-c2ccccc2)cc1 CHEMBL1969473 Ki 0.601 nM
CC(C)(CO)CCCNc1cc(-c2c[nH]c3ncccc23)cc(Cl)n1 CHEMBL1967662 pKi 0.631 nM
CS(=O)(=O)NC1CCCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)C1 CHEMBL1987948 pKi 0.631 nM
COc1cccc(C(=O)Nc2n[nH]c3ccc(-c4cn(Cc5ccccc5)nn4)cc23)c1 CHEMBL1980435 pKi 0.7943 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4cccc(Cl)c4)c3)cc12 CHEMBL1974870 pKi 0.7943 nM
CC(=O)NC1CCCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)C1 CHEMBL1980178 pKi 0.7943 nM
O=C(Nc1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12)c1cccc(Cl)c1 CHEMBL1983595 pKi 0.7943 nM
CCCC(=O)Nc1cc(-c2c[nH]c3ncccc23)cc(Cl)n1 CHEMBL1998470 pKi 0.7943 nM
O=C(Nc1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12)c1ccc(F)cc1 CHEMBL1966204 pKi 0.7943 nM
C=CCNc1cc(-c2c[nH]c3ncccc23)cc(Cl)n1 CHEMBL1996339 pKi 0.7943 nM
OCCCCNc1cc(-c2c[nH]c3ncccc23)cc(Cl)n1 CHEMBL1970821 pKi 0.7943 nM
Nc1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3-c3ccc(F)cc3)cc12 CHEMBL1986499 Ki 0.8 nM
O=C(Nc1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3-c3ccccc3)cc12)c1ccccc1 CHEMBL3912696 Ki 0.8 nM
Clc1cc(-c2c[nH]c3ncccc23)cc(NC2CCCCC2)n1 CHEMBL2322677 Ki 0.9 nM
O=C(Nc1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3C3CC3)cc12)c1cccc(F)c1 CHEMBL3964735 Ki 0.9 nM
CC(C)C1CNC(=O)c2cc(-c3ccnc(N)n3)[nH]c21 CHEMBL445340 IC50 1.0 nM
CC(C)(CNc1cc(-c2c[nH]c3ncccc23)cc(Cl)n1)CNS(C)(=O)=O CHEMBL1971172 pKi 1.0 nM
CS(=O)(=O)NCCNc1cc(-c2c[nH]c3ncccc23)cc(Cl)n1 CHEMBL2005718 pKi 1.0 nM
CC(C)CNC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL2006456 pKi 1.0 nM
NC1CCCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)C1 CHEMBL1998432 pKi 1.0 nM
OC1CCC(Nc2cc(Cl)nc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1991674 pKi 1.0 nM
OC1CCCC(Nc2cc(Cl)nc(-c3c[nH]c4ncccc34)n2)C1 CHEMBL1976936 pKi 1.0 nM
c1cnc2[nH]cc(-c3ccnc(NC4CCCCC4)n3)c2c1 CHEMBL385478 pKi 1.0 nM
CC(C)(CN)CNc1nc(Cl)cc(-c2c[nH]c3ncccc23)n1 CHEMBL1968930 pKi 1.0 nM
COc1ccc(CNc2cc(-c3c[nH]c4ncccc34)cc(F)n2)cc1 CHEMBL1986855 pKi 1.0 nM
O=C1C/C(=N/c2ccc3[nH]ncc3c2)O/C1=C\c1c[nH]c2ncccc12 CHEMBL3670786 IC50 1.0 nM
Cc1ccsc1C/N=C1/CC(=O)/C(=C/c2c[nH]c3ncccc23)O1 CHEMBL3972853 IC50 1.0 nM
Fc1ccc(-c2c(-c3ccc4[nH]ncc4c3)nnn2CC2CCOCC2)cc1 CHEMBL3974914 Ki 1.05 nM
Nc1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3Cc3ccccc3)cc12 CHEMBL3959601 Ki 1.1 nM
Nc1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3-c3ccccc3)cc12 CHEMBL1972158 Ki 1.2 nM
NC1CCC(Nc2cc(Cl)nc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1983589 pKi 1.259 nM
N#Cc1cccc(C(=O)Nc2n[nH]c3ccc(-c4cn(Cc5ccccc5)nn4)cc23)c1 CHEMBL1977128 pKi 1.259 nM
COc1ccc(C(=O)Nc2n[nH]c3ccc(-c4cn(Cc5ccccc5)nn4)cc23)cc1OC CHEMBL1991078 pKi 1.259 nM
Cc1cccc(CNc2cc(-c3c[nH]c4ncccc34)cc(Cl)n2)c1C CHEMBL1988331 pKi 1.259 nM
FC(F)(F)c1ccccc1CNc1nccc(-c2c[nH]c3ncccc23)n1 CHEMBL1999153 pKi 1.259 nM
O=C(Nc1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12)c1ccc(Cl)cc1 CHEMBL1987073 pKi 1.259 nM
Cc1cc(-c2cc(-c3ccccc3)[nH]c(=O)n2)ccc1O CHEMBL501724 IC50 1.4 nM
N#Cc1cc(-c2c[nH]c3ncccc23)cc(NCc2ccccc2)n1 CHEMBL2322674 Ki 1.4 nM
O=C(Nc1cc(-c2c[nH]c3ncccc23)cc(Cl)n1)c1ccccc1 CHEMBL1993413 pKi 1.585 nM
Nc1cc(-c2c[nH]c3ncccc23)cc(Cl)n1 CHEMBL1987448 pKi 1.585 nM
O[C@H]1CC[C@H](Nc2cc(-c3c[nH]c4ncccc34)cc(F)n2)CC1 CHEMBL2322683 Ki 1.7 nM
Cn1cc(-c2c(-c3ccc4[nH]nc(N)c4c3)nnn2Cc2ccccc2)cn1 CHEMBL3933471 Ki 1.9 nM
Cc1n[nH]cc1-c1cc2nc([C@@H]3CCCCN3)[nH]c(=O)c2s1 CHEMBL4439133 Kd 1.96 nM
CC(C)(CN)CNc1cc(-c2c[nH]c3ncccc23)cc(F)n1 CHEMBL1987261 pKi 1.995 nM
COCCNc1cc(-c2c[nH]c3ncccc23)cc(Cl)n1 CHEMBL1964340 pKi 1.995 nM
COCC(C)Nc1cc(-c2c[nH]c3ncccc23)cc(Cl)n1 CHEMBL1998068 pKi 1.995 nM
CN(C)CC(=O)NC1CCCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)C1 CHEMBL1995712 pKi 1.995 nM
CC(C)(O)CNc1cc(-c2c[nH]c3ncccc23)cc(Cl)n1 CHEMBL2005387 pKi 1.995 nM
Clc1cc(NC2CCCCC2)nc(-c2c[nH]c3ncccc23)n1 CHEMBL1997846 pKi 1.995 nM
O=C1NCCc2[nH]c3c(ccc4cnccc43)c21 CHEMBL399492 IC50 2.0 nM
Nc1nccc(-c2cc3c([nH]2)[C@@H](CCF)CNC3=O)n1 CHEMBL524266 IC50 2.0 nM
Nc1nccc(-c2cc3c([nH]2)C(C2CCC2)CNC3=O)n1 CHEMBL497995 IC50 2.0 nM
CC1(C)CNC(=O)c2cc(-c3ccnc(N)c3)[nH]c21 CHEMBL496961 IC50 2.0 nM
O=C1NCC(CCF)c2[nH]c(-c3ccncc3)cc21 CHEMBL447369 IC50 2.0 nM
CCC1CNC(=O)c2cc(-c3ccncc3)[nH]c21 CHEMBL495757 IC50 2.0 nM
NC(=O)c1cc(-c2nc(N)ncc2Br)[nH]c1-c1ccccc1 CHEMBL1271443 IC50 2.0 nM
CCOC(=O)C1C(=O)/C(=C/c2c[nH]c3ncccc23)O/C1=N\c1ccccc1Cl CHEMBL3951396 IC50 2.0 nM
Cc1cc(F)ccc1/N=C1/CC(=O)/C(=C/c2c[nH]c3ncccc23)O1 CHEMBL4114785 IC50 2.0 nM
Cc1ccccc1-c1c(-c2ccc3[nH]nc(C)c3c2)nnn1Cc1ccccc1 CHEMBL1983315 Ki 2.25 nM
CC(C)(C)Oc1cc(-c2ccncc2)cc2[nH]nc(N)c12 CHEMBL2002456 pKi 2.512 nM
O=c1cc(-c2ccncc2)nc(NC2CCCCC2)[nH]1 CHEMBL1958401 pKi 2.512 nM
NCCNc1cc(-c2c[nH]c3ncccc23)cc(Cl)n1 CHEMBL1972290 pKi 2.512 nM
Cc1cccc(CNc2cc(-c3c[nH]c4ncccc34)ncn2)c1 CHEMBL1995932 pKi 2.512 nM
O=C1NCCc2[nH]c(-c3ccncc3)cc21 CHEMBL225519 pKi 2.512 nM
Cn1cc(Nc2ncc(Br)c(Nc3ccccc3C(N)=O)n2)cn1 CHEMBL1994669 pKi 2.512 nM
O=C(O)c1ccccc1Nc1ncnc(Nc2ccc(F)cc2)n1 CHEMBL1992231 pKi 2.512 nM
O=C(Nc1cc(-c2c[nH]c3ncccc23)cc(Cl)n1)c1c(F)cccc1F CHEMBL1991410 pKi 2.512 nM
OCCNc1cc(-c2c[nH]c3ncccc23)cc(Cl)n1 CHEMBL1989006 pKi 2.512 nM
Nc1nccc(-c2cc3c(n2CCF)CCNC3=O)n1 CHEMBL250062 IC50 3.0 nM
Nc1nccc(-c2cc3c([nH]2)C(CCF)CNC3=O)n1 CHEMBL443669 IC50 3.0 nM
CC1(C)CNC(=O)c2cc(-c3ccncc3)[nH]c21 CHEMBL459285 IC50 3.0 nM
O=C1NCC(C2CCC2)c2[nH]c(-c3ccncc3)cc21 CHEMBL509776 IC50 3.0 nM
CC(C)CC1Cc2[nH]c(-c3ccncc3)cc2C(=O)N1 CHEMBL496772 IC50 3.0 nM
O=C(OCCCO)C1C(=O)/C(=C/c2c[nH]c3ncccc23)O/C1=N\c1ccc(F)cc1 CHEMBL3924774 IC50 3.0 nM
CCOC(=O)C1C(=O)/C(=C/c2c[nH]c3ncccc23)O/C1=N\c1ccc(NCCO)cc1C CHEMBL4114693 IC50 3.0 nM
CCOC(=O)C1C(=O)/C(=C/c2c[nH]c3ncccc23)O/C1=N\N1CCOCC1 CHEMBL3670781 IC50 3.0 nM
Cc1cc(OCCO)ccc1/N=C1\O/C(=C\c2c[nH]c3ncccc23)C(=O)C1C(=O)OC(C)C CHEMBL3670782 IC50 3.0 nM
COCCOC(=O)C1C(=O)/C(=C/c2c[nH]c3ncccc23)O/C1=N\c1ccccc1Cl CHEMBL3903885 IC50 3.0 nM
CN(C)C1CCCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)C1 CHEMBL1965702 pKi 3.162 nM
c1ccc(CNc2cc(-c3c[nH]c4ncccc34)ncn2)cc1 CHEMBL2002346 pKi 3.162 nM
Cc1ccccc1-c1c(-c2ccc3[nH]nc(N)c3c2)nnn1Cc1ccccc1 CHEMBL2000029 pKi 3.162 nM
N#Cc1ccc(C(=O)Nc2n[nH]c3ccc(-c4cn(Cc5ccccc5)nn4)cc23)cc1 CHEMBL1990162 pKi 3.162 nM
O=C(Nc1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12)c1cc(F)ccc1F CHEMBL1995811 pKi 3.162 nM
Fc1cc(-c2c[nH]c3ncccc23)cc(NC2CCCCC2)n1 CHEMBL2322682 Ki 3.2 nM
O=c1[nH]c([C@@H]2CCCN2)nc2c1oc1ccc(Cl)cc12 CHEMBL2030402 IC50 3.4 nM
N[C@H]1CC[C@H](Nc2cc(-c3c[nH]c4ncccc34)cc(F)n2)CC1 CHEMBL2322684 Ki 3.4 nM
O=c1[nH]c(CN2CCCC2)nc2c1oc1ccc(Br)cc12 CHEMBL2030389 IC50 3.7 nM
O=c1[nH]c([C@@H]2C[C@@H](F)CN2)nc2c1oc1ccc(Br)cc12 CHEMBL2030400 IC50 3.7 nM
COc1ccc2oc3c(=O)[nH]c([C@@H]4C[C@@H](F)CN4)nc3c2c1 CHEMBL2030405 IC50 3.9 nM
O=C1Nc2ccccc2Nc2cc(-c3ccncc3F)ccc21 CHEMBL1989293 pKi 3.981 nM
COc1ccccc1C(=O)Nc1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12 CHEMBL1997643 pKi 3.981 nM
Nc1nccc(-c2cc3c(n2CC2CC2)CCNC3=O)n1 CHEMBL250061 IC50 4.0 nM
Nc1ncc(Br)c(-c2cc3c([nH]2)CCNC3=O)n1 CHEMBL253768 IC50 4.0 nM
CCC1CNC(=O)c2cc(-c3ccnc(N)n3)[nH]c21 CHEMBL526092 IC50 4.0 nM
Nc1nccc(-c2cc3c([nH]2)C(CCO)CNC3=O)n1 CHEMBL451213 IC50 4.0 nM
O=C1N=C(NCc2ccco2)S/C1=C\c1c[nH]c2ncccc12 CHEMBL484146 IC50 4.0 nM
O=c1[nH]c([C@@H]2C[C@@H](F)CN2)nc2c1oc1ccc(Cl)cc12 CHEMBL2030404 IC50 4.0 nM
CCOC(=O)C1C(=O)/C(=C/c2c[nH]c3ncccc23)O/C1=N\c1ccc2c[nH]nc2c1 CHEMBL3670773 IC50 4.0 nM
CN(C)CCOC(=O)C1C(=O)/C(=C/c2c[nH]c3ncccc23)O/C1=N\c1ccc(F)cc1F CHEMBL3670777 IC50 4.0 nM
CCOC(=O)C1=C(N2CCc3ccccc3C2)O/C(=C\c2c[nH]c3ncccc23)C1=O CHEMBL3670778 IC50 4.0 nM
O=C1C/C(=N/C2CCCCCC2)O/C1=C\c1c[nH]c2ncccc12 CHEMBL3670784 IC50 4.0 nM
CCOC(=O)C1=C(N2CCc3ccc(OC)cc3C2)O/C(=C\c2c[nH]c3ncccc23)C1=O CHEMBL3670788 IC50 4.0 nM
O=c1[nH]c([C@@H]2CCCN2)nc2c1oc1ccc(Br)cc12 CHEMBL2030393 IC50 4.8 nM
c1ccc(Cn2cc(-c3ccc4[nH]nc(-c5cccs5)c4c3)nn2)cc1 CHEMBL3938656 Ki 4.92 nM
Nc1nccc(-c2cc3c(n2CC(F)(F)F)CCNC3=O)n1 CHEMBL430021 IC50 5.0 nM
O=c1nc(-c2ccc3[nH]ncc3c2)cc(-c2cccc(Cl)c2)[nH]1 CHEMBL508883 IC50 5.0 nM
Nc1nccc(-c2cc3c([nH]2)[C@H](CCF)CNC3=O)n1 CHEMBL451570 IC50 5.0 nM
CCC1(CC)CNC(=O)c2cc(-c3ccnc(N)n3)[nH]c21 CHEMBL449372 IC50 5.0 nM
O=C1NC(C2CC2)Cc2[nH]c(-c3ccncc3)cc21 CHEMBL525775 IC50 5.0 nM
NC(=O)c1cc(-c2nc(N)ncc2Cl)[nH]c1-c1ccccc1 CHEMBL1271442 IC50 5.0 nM
CCOC(=O)C1C(=O)C(Cc2c[nH]c3ncccc23)=C/C1=N\c1ccc(OCCO)cc1F CHEMBL3670775 IC50 5.0 nM
NC1CCC(Nc2nccc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1966628 pKi 5.012 nM
NC(=O)c1ccccc1Nc1nc(Nc2ccccc2)ncc1C(F)(F)F CHEMBL1997554 pKi 5.012 nM
CCOC(=O)c1c[nH]n2c(=O)cc(-c3ccncc3)nc12 CHEMBL1990708 pKi 5.012 nM
Cn1cc(Nc2ncc(Cl)c(Nc3ccccc3C(N)=O)n2)cn1 CHEMBL1984548 pKi 5.012 nM
NC1CCCCC1Nc1nc(Cl)cc(-c2c[nH]c3ncccc23)n1 CHEMBL1994438 pKi 5.012 nM
O=C(NCc1ccccc1)c1c[nH]n2c(=O)cc(-c3ccncc3)nc12 CHEMBL1974250 pKi 5.012 nM
O=c1nc(-c2ccc3[nH]ncc3c2)cc(-c2ccccc2)[nH]1 CHEMBL526133 pKi 5.012 nM
CNS(=O)(=O)c1ccccc1Nc1nc(Nc2cc(OC)c(OC)c(OC)c2)ncc1Cl CHEMBL1993661 pKi 5.012 nM
O=c1[nH]c(CN2CC[C@@H](O)C2)nc2c1oc1ccc(Br)cc12 CHEMBL2030386 IC50 5.5 nM
N#Cc1cc(-c2c[nH]c3ncccc23)cc(N[C@H]2CC[C@H](O)CC2)n1 CHEMBL2322675 Ki 5.5 nM
O=c1nc(-c2ccc3[nH]ncc3c2)cc(-c2cccc(OCc3ccccc3)c2)[nH]1 CHEMBL500662 IC50 6.0 nM
CC1CNC(=O)c2cc(-c3ccnc(N)n3)[nH]c21 CHEMBL459284 IC50 6.0 nM
CCC1(CC)CNC(=O)c2cc(-c3ccncc3)[nH]c21 CHEMBL459283 IC50 6.0 nM
CC(C)C1Cc2[nH]c(-c3ccncc3)cc2C(=O)N1 CHEMBL444154 IC50 6.0 nM
CCOC(=O)C1=C(N2CCCCCC2)O/C(=C\c2c[nH]c3ncccc23)C1=O CHEMBL3670772 IC50 6.0 nM
COc1ccc2oc3c(=O)[nH]c([C@@H]4CCCN4)nc3c2c1 CHEMBL2030403 IC50 6.1 nM
O=c1[nH]c(C2CCNCC2)nc2c1oc1ccc(Br)cc12 CHEMBL2030396 IC50 6.2 nM
O=C(Nc1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3C3CC3)cc12)c1cccc(Cl)c1 CHEMBL3970165 Ki 6.3 nM
Cc1cccc(-c2[nH]c(-c3ccnc(N)n3)cc2C(N)=O)c1C CHEMBL1964290 pKi 6.31 nM
CCCCNc1cc(-c2c[nH]c3ncccc23)ncn1 CHEMBL1968459 pKi 6.31 nM
CC(C)(CN)CNc1cc(-c2c[nH]c3ncccc23)cc(Cl)n1 CHEMBL1985723 pKi 6.31 nM
O=c1cc(-c2ccncc2)nc(NCc2cc(F)cc(F)c2)[nH]1 CHEMBL2003682 pKi 6.31 nM
COc1cc(Nc2ncc([N+](=O)[O-])c(Nc3ccccc3C(N)=O)n2)cc(OC)c1OC CHEMBL1241473 pKi 6.31 nM
O=[N+]([O-])c1cccc(-c2nnc3ccc(N4CCCCC4)nn23)c1 CHEMBL2003637 pKi 6.31 nM
O=C1NCCc2[nH]c(-c3ccnc(Nc4ccccc4)n3)cc21 CHEMBL401396 IC50 7.0 nM
Nc1nccc(-c2cc3c([nH]2)CCNC3=O)n1 CHEMBL402272 IC50 7.0 nM
Nc1nccc(-c2cc3c([nH]2)C(CCOCc2ccccc2)CNC3=O)n1 CHEMBL498207 IC50 7.0 nM
Nc1nccc(-n2cc(-c3cccnc3Cl)c3cnccc32)n1 CHEMBL2348154 IC50 7.0 nM
CN1CCC[C@H]1c1nc2c(oc3ccc(Br)cc32)c(=O)[nH]1 CHEMBL2030398 IC50 7.3 nM
O=c1[nH]c(CN2CC[C@H](O)C2)nc2c1oc1ccc(Br)cc12 CHEMBL2030376 IC50 7.7 nM
O=c1[nH]c(C2CNC2)nc2c1oc1ccc(Br)cc12 CHEMBL2030392 IC50 7.7 nM
N#Cc1cc(-c2c[nH]c3ncccc23)cc(NC2CCCCC2)n1 CHEMBL2322673 Ki 7.7 nM
c1ccc(Cn2cc(-c3ccc4[nH]nc(-c5ccccc5)c4c3)nn2)cc1 CHEMBL1982400 Ki 7.7 nM
CC(N)c1nc2c(oc3ccc(Br)cc32)c(=O)[nH]1 CHEMBL2030397 IC50 7.9 nM
Nc1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3I)cc12 CHEMBL1975128 pKi 7.943 nM
CN(Cc1ccccc1)c1cc(-c2c[nH]c3ncccc23)cc(Cl)n1 CHEMBL1969920 pKi 7.943 nM
c1cnc2[nH]cc(-c3ccnc(NCC4CCCCC4)n3)c2c1 CHEMBL213207 pKi 7.943 nM
NC(=O)c1ccc(-c2ccnc(N)n2)cc1N1CCCCC1 CHEMBL1971951 pKi 7.943 nM
COc1cc(Nc2ncc(F)c(Nc3ccc4c(n3)NC(=O)C(C)(C)O4)n2)cc(OC)c1OC CHEMBL475251 pKi 7.943 nM
O=C1Nc2ccccc2Nc2cc(-c3ccncc3)ccc21 CHEMBL1989136 pKi 7.943 nM
CCn1c(-c2ccnc(N)n2)cc2c1CCNC2=O CHEMBL248853 IC50 8.0 nM
CC(C)CC1Cc2[nH]c(-c3ccnc(N)n3)cc2C(=O)N1 CHEMBL495953 IC50 8.0 nM
NC(=O)c1cc(-c2ccncc2)[nH]c1-c1ccccc1F CHEMBL1270015 IC50 8.0 nM
NC(=O)c1cc(-c2ccncc2F)[nH]c1-c1ccccc1 CHEMBL1271441 IC50 8.0 nM
CC(C)OC(=O)C1C(=O)/C(=C/c2c[nH]c3ncccc23)O/C1=N\N1CCOCC1 CHEMBL3670789 IC50 8.0 nM
CCOC(=O)C1C(=O)/C(=C/c2c[nH]c3ncccc23)O/C1=N\N1CCN(CC(F)(F)F)CC1 CHEMBL3670790 IC50 8.0 nM
Nc1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3CC3CCCCC3)cc12 CHEMBL3950878 Ki 8.2 nM
c1cnc2[nH]cc(-c3ccnc(NC4CCCCC4)c3)c2c1 CHEMBL2322678 Ki 8.7 nM
O=C1NCCc2[nH]c(-c3ccncc3F)cc21 CHEMBL253545 IC50 9.0 nM
O=C1N=C(NCc2ccccc2)S/C1=C\c1c[nH]c2ncccc12 CHEMBL484990 IC50 9.0 nM
NC(=O)c1cc(-c2ccncc2)[nH]c1-c1ccccc1 CHEMBL1269057 IC50 9.0 nM
N#Cc1ccc2ccn(-c3cc(N)ncn3)c2n1 CHEMBL2348153 IC50 9.0 nM
CCOC(=O)C1C(=O)/C(=C/c2c[nH]c3ncccc23)O/C1=N\c1ccc(CN(C)C)cc1C CHEMBL3670780 IC50 9.0 nM
O=c1[nH]c([C@@H]2C[C@@H](O)CN2)nc2c1oc1ccc(Br)cc12 CHEMBL2030399 IC50 9.1 nM
O=c1nc(-c2ccc3[nH]ncc3c2)cc(-c2ccccc2F)[nH]1 CHEMBL502268 IC50 10.0 nM
Nc1nccc(-c2cc3c([nH]2)C(CCC(F)(F)F)CNC3=O)n1 CHEMBL498200 IC50 10.0 nM
CC(C)C1CNC(=O)c2cc(-c3ccncc3)[nH]c21 CHEMBL513429 IC50 10.0 nM
CC1CNC(=O)c2cc(-c3ccncc3)[nH]c21 CHEMBL495947 IC50 10.0 nM
CC(C)NC1=NC(=O)/C(=C/c2c[nH]c3ncccc23)S1 CHEMBL484991 IC50 10.0 nM
NC1CCCCC1Nc1nccc(-c2c[nH]c3ncccc23)n1 CHEMBL1995813 pKi 10.0 nM
Cc1n[nH]c2cnc(-c3cncc(OCC(N)Cc4cccc(C(F)(F)F)c4)c3)cc12 CHEMBL1998159 pKi 10.0 nM
Nc1nc(Cl)cc(-c2c[nH]c3ncccc23)n1 CHEMBL2007574 pKi 10.0 nM
COCCN(CCOC)c1cc(-c2c[nH]c3ncccc23)cc(Cl)n1 CHEMBL1985654 pKi 10.0 nM
CCCCNc1c(-c2ccc3[nH]ncc3c2)nc2ncccn12 CHEMBL1682554 pKi 10.0 nM
N[C@H]1CCN(Cc2nc3c(oc4ccc(Br)cc43)c(=O)[nH]2)C1 CHEMBL2030387 IC50 10.0 nM
O=C(O)C1C(=O)/C(=C/c2c[nH]c3ncccc23)O/C1=N\c1ccccc1 CHEMBL3670771 IC50 10.0 nM
Nc1nccc(-c2cc3c([nH]2)CC(C2CC2)NC3=O)n1 CHEMBL523902 IC50 11.0 nM
CO[C@H]1CCN(Cc2nc3c(oc4ccc(Br)cc43)c(=O)[nH]2)C1 CHEMBL2030390 IC50 11.0 nM
O=c1[nH]c([C@@H]2C[C@H](F)CN2)nc2c1oc1ccc(Br)cc12 CHEMBL2030401 IC50 11.0 nM
Nc1nccc(-n2cc(-c3ccccc3Cl)c3cnccc32)n1 CHEMBL2348156 IC50 11.0 nM
CCOC(=O)C1=C(N2CCC(C)CC2)O/C(=C\c2c[nH]c3ncccc23)C1=O CHEMBL3670774 IC50 11.0 nM
CCCn1c(-c2ccnc(N)n2)cc2c1CCNC2=O CHEMBL398627 IC50 12.0 nM
Nc1nccc(-c2cc3c([nH]2)C(CCCO)CNC3=O)n1 CHEMBL496560 IC50 12.0 nM
CC(C)C1Cc2[nH]c(-c3ccnc(N)n3)cc2C(=O)N1 CHEMBL522717 IC50 12.0 nM
Nc1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12 CHEMBL1682346 Ki 12.0 nM
CCCC(=O)Nc1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3-c3ccccc3)cc12 CHEMBL2005936 pKi 12.59 nM
CN(C)CCCOc1cc(-c2ccncc2)cc2[nH]nc(N)c12 CHEMBL1988662 pKi 12.59 nM
O=c1[nH]c2sc3c(c2c2nc(-c4ccncc4)nn12)CCCC3 CHEMBL1966808 pKi 12.59 nM
CCCCNc1cc(-c2ccncc2)cc2[nH]nc(N)c12 CHEMBL1983157 pKi 12.59 nM
FC(F)(F)c1cccc(CNc2cc(-c3c[nH]c4ncccc34)ncn2)c1 CHEMBL1966040 pKi 12.59 nM
NCCCn1cc(-c2cc(-c3cc4ccccc4s3)c3[nH]ncc3c2)c2nc(N)ncc21 CHEMBL592030 pKi 12.59 nM
CN(C)c1cc(-c2ccncc2)cc2[nH]nc(N)c12 CHEMBL2003229 pKi 12.59 nM
Cc1n[nH]c2ccc(-c3cncc(OCCN(C)S(C)(=O)=O)c3)cc12 CHEMBL1998826 pKi 12.59 nM
NC(=O)c1ccc(Nc2ncnc3[nH]cc(-c4ccccc4)c23)cc1 CHEMBL1975440 pKi 12.59 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4c[nH]c5ccccc45)c3)cc12 CHEMBL1970903 pKi 12.59 nM
OC1CCN(c2ncnc3[nH]cc(-c4ccccc4)c23)CC1 CHEMBL1973395 pKi 12.59 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4ccc(Cl)c(Cl)c4)c3)cc12 CHEMBL1991063 pKi 12.59 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4ccccc4)c3)cc12 CHEMBL2002726 pKi 12.59 nM
Clc1ccc(Cn2cc(-c3ccc4[nH]ncc4c3)nn2)c(Cl)c1 CHEMBL3968307 Ki 12.7 nM
CC(C)Cn1c(-c2ccnc(N)n2)cc2c1CCNC2=O CHEMBL400270 IC50 13.0 nM
CC1Cc2[nH]c(-c3ccncc3)cc2C(=O)N1 CHEMBL449148 IC50 13.0 nM
CC1CCC(NC2=N/C(=C\c3c[nH]c4ncccc34)C(=O)N2)CC1 CHEMBL502564 IC50 13.0 nM
CC(C)NC1=N/C(=C\c2c[nH]c3ncccc23)C(=O)N1 CHEMBL498717 IC50 13.0 nM
O=C(O)C1CCN(Cc2nc3c(oc4ccc(Br)cc43)c(=O)[nH]2)C1 CHEMBL2030391 IC50 13.0 nM
Cc1cc(-c2c[nH]c3ncccc23)cc(NC2CCCCC2)n1 CHEMBL2322679 Ki 13.0 nM
COc1ccc(NC(=O)Nc2n[nH]c3ccc(-c4nnn(Cc5ccccc5)c4-c4ccccc4)cc23)cc1 CHEMBL3927401 Ki 13.0 nM
Nc1nccc(-c2cc3c(n2C2CCC2)CCNC3=O)n1 CHEMBL398833 IC50 14.0 nM
O=C1NCCc2[nH]c(-c3ccnc4[nH]ccc34)cc21 CHEMBL253760 IC50 14.0 nM
NC(=O)c1cc(-c2ccncc2)[nH]c1-c1ccc(F)cc1 CHEMBL1270122 IC50 14.0 nM
O=C1NC(NCc2ccco2)=N/C1=C\c1c[nH]c2ncccc12 CHEMBL525228 IC50 15.0 nM
O=c1[nH]c(C2CCCNC2)nc2c1oc1ccc(Br)cc12 CHEMBL2030395 IC50 15.0 nM
Cc1cc(-c2c[nH]c3ncccc23)cc(NCc2ccccc2)n1 CHEMBL2322680 Ki 15.0 nM
COCC(=O)Nc1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12 CHEMBL3907396 Ki 15.0 nM
Clc1ccc(CNc2n[nH]c3ccc(-c4nnn(Cc5ccccc5)c4C4CC4)cc23)cc1 CHEMBL3891667 Ki 15.0 nM
Cn1cc(-c2ccccc2)c2nc(-c3ccncc3)cc(=O)n21 CHEMBL1986767 pKi 15.85 nM
CCCCOc1cc(-c2ccncc2)cc2[nH]nc(N)c12 CHEMBL1996447 pKi 15.85 nM
Cc1c(-c2ccc3[nH]nc(N)c3c2)nnn1Cc1ccccc1 CHEMBL1989646 Ki 17.0 nM
O=C1NC(NCc2cccs2)=N/C1=C\c1c[nH]c2ncccc12 CHEMBL444760 IC50 18.0 nM
O=C1NC(NCCc2ccccc2)=N/C1=C\c1c[nH]c2ncccc12 CHEMBL526695 IC50 18.0 nM
NC(=O)c1cc(-c2nc(N)ncc2F)[nH]c1-c1ccccc1 CHEMBL1271334 IC50 18.0 nM
Nc1nccc(-c2cc3c([nH]2)C(c2ccccc2)CNC3=O)n1 CHEMBL522578 IC50 19.0 nM
CC(C)(Nc1nccc(-c2c[nH]c3ncccc23)n1)c1ccccc1 CHEMBL1999279 pKi 19.95 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4cccc(OC(F)(F)F)c4)c3)cc12 CHEMBL1965836 pKi 19.95 nM
COc1ccc(-c2cc3nccn3c(Nc3ncccc3C(N)=O)n2)cc1OC CHEMBL1190711 pKi 19.95 nM
O=C1Nc2ccccc2Nc2cc(-c3ccncc3Cl)ccc21 CHEMBL1987745 pKi 19.95 nM
Cc1sc2[nH]c(=O)n3nc(-c4ccncc4)nc3c2c1C CHEMBL1980592 pKi 19.95 nM
O=C1NCCc2[nH]c(-c3ccncn3)cc21 CHEMBL1203954 IC50 20.0 nM
O=C1NCC(c2ccccc2)c2[nH]c(-c3ccncc3)cc21 CHEMBL512744 IC50 20.0 nM
O=C1NC(NCc2ccccc2)=N/C1=C\c1c[nH]c2ncccc12 CHEMBL525012 IC50 20.0 nM
Fc1ccccc1[C@H](Nc1nnc(-c2c[nH]c3ncccc23)o1)C1CC1 CHEMBL3093075 IC50 20.0 nM
Nc1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3CC3CCCC3)cc12 CHEMBL3897033 Ki 20.0 nM
C[C@H](NC1=N/C(=C\c2c[nH]c3ncccc23)C(=O)N1)c1ccccc1 CHEMBL448860 IC50 21.0 nM
O=C1NC(NC2CCCCC2)=N/C1=C\c1c[nH]c2ncccc12 CHEMBL499637 IC50 21.0 nM
O=C1NC(NCC2CCCO2)=N/C1=C\c1c[nH]c2ncccc12 CHEMBL502296 IC50 21.0 nM
NC(=O)c1cc(-c2ccnc(N)n2)[nH]c1-c1ccccc1 CHEMBL1270230 IC50 22.0 nM
NC(=O)c1cc(-c2ccnc(N)n2)[nH]c1-c1cccs1 CHEMBL1269728 IC50 22.0 nM
NC(=O)N(c1ccccc1Cl)c1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3C3CC3)cc12 CHEMBL3953310 Ki 22.0 nM
CCCCn1c(-c2ccnc(N)n2)cc2c1CCNC2=O CHEMBL251247 IC50 23.0 nM
NC(=O)c1cc(-c2ccncc2)[nH]c1-c1cccc(F)c1 CHEMBL1270016 IC50 23.0 nM
COc1ccc(-c2[nH]c(-c3ccncc3)cc2C(N)=O)cc1 CHEMBL1270424 IC50 23.0 nM
Nc1nccc(-c2cc3c([nH]2)C(CCCOCc2ccccc2)CNC3=O)n1 CHEMBL522398 IC50 24.0 nM
CC(C)(C)CCNC1=N/C(=C\c2c[nH]c3ncccc23)C(=O)N1 CHEMBL484988 IC50 24.0 nM
O=C1NC(N2CCCCC2)=N/C1=C\c1c[nH]c2ncccc12 CHEMBL497063 IC50 25.0 nM
CNc1nccc(-n2ccc3ccc(C#N)cc32)n1 CHEMBL2348182 IC50 25.0 nM
CCn1c(C)c(-c2ccnc(Nc3cccc(OC)c3)n2)sc1=O CHEMBL1986263 pKi 25.12 nM
CC1Cc2[nH]c(-c3ccnc(N)n3)cc2C(=O)N1 CHEMBL495750 IC50 26.0 nM
C[C@H](NC1=NC(=O)/C(=C/c2c[nH]c3ncccc23)S1)c1ccccc1 CHEMBL521003 IC50 26.0 nM
O=C1NCc2[nH]c(-c3ccncc3)cc21 CHEMBL250693 IC50 27.0 nM
Cc1cc(-c2c[nH]c3ncccc23)cc(N[C@H]2CC[C@H](O)CC2)n1 CHEMBL2322681 Ki 27.0 nM
Nc1cc(-c2cc3c([nH]2)CCNC3=O)ccn1 CHEMBL254597 IC50 28.0 nM
O=c1nc(-c2ccc(O)cc2)cc(-c2ccccc2)[nH]1 CHEMBL450151 IC50 30.0 nM
Cc1cccc(C2=N/C(=C\c3c[nH]c4ncccc34)C(=O)N2)c1 CHEMBL523244 IC50 30.0 nM
Nc1nccc(-n2cc(-c3cccnc3Cl)c3cnc(Cl)cc32)n1 CHEMBL2348152 IC50 30.0 nM
Cc1ccccc1-c1c(-c2ccc3[nH]nc(N)c3c2)nnn1CC1CCOCC1 CHEMBL3986318 Ki 30.0 nM
N#CCOc1ccc(Nc2nc(Nc3cccc(S(N)(=O)=O)c3)ncc2Br)cc1 CHEMBL1987034 pKi 31.62 nM
Cc1cc(C)c2c(n1)sc1c(N)ncnc12 CHEMBL504950 pKi 31.62 nM
c1ccc(-c2c[nH]c3ncnc(N4CCCCC4)c23)cc1 CHEMBL1998953 pKi 31.62 nM
NC1CCCCC1Nc1nccc(Nc2ccccc2C(=O)O)n1 CHEMBL1985153 pKi 31.62 nM
CNCCOc1cncc(-c2ccc3[nH]nc(C)c3c2)c1 CHEMBL1983855 pKi 31.62 nM
Nc1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3C3CC3)cc12 CHEMBL2004631 pKi 31.62 nM
Nc1n[nH]c2ccc(-c3cc(Cc4ccccc4)no3)cc12 CHEMBL1682358 pKi 31.62 nM
O=C(O)c1ccccc1Nc1ccnc(NCc2cccc(O)c2)n1 CHEMBL1970950 pKi 31.62 nM
CC1(C)Cc2[nH]c(-c3ccncc3)cc2C(=O)N1 CHEMBL496773 IC50 32.0 nM
Fc1cnc2[nH]cc(-c3nnc(N[C@@H](c4cccnc4F)C4CC4)o3)c2c1 CHEMBL3093080 IC50 32.0 nM
O=C1NC(NC2CC2)=N/C1=C\c1c[nH]c2ncccc12 CHEMBL524910 IC50 33.0 nM
CCNC(=O)Nc1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12 CHEMBL3914700 Ki 34.0 nM
CCCCCNC1=N/C(=C\c2c[nH]c3ncccc23)C(=O)N1 CHEMBL524295 IC50 35.0 nM
NC(=O)c1cc(-c2ccnc(N)n2)n(CC(F)(F)F)c1-c1ccccc1 CHEMBL1270925 IC50 36.0 nM
CCOC(=O)C1=C(NN2CCN(CC(F)(F)F)CC2)O/C(=C\c2c[nH]c3ncccc23)C1=O CHEMBL4868568 IC50 36.0 nM
O=C1NC(NCCO)=N/C1=C\c1c[nH]c2ncccc12 CHEMBL484989 IC50 37.0 nM
Nc1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3C3CCCCC3)cc12 CHEMBL3968211 Ki 37.0 nM
Fc1ccc(CNc2n[nH]c3ccc(-c4cn(Cc5ccccc5)nn4)cc23)c(F)c1 CHEMBL3941781 Ki 37.0 nM
NC(=O)c1c(-c2ccccc2)[nH]c(-c2ccnc(N)n2)c1Cl CHEMBL1270716 IC50 38.0 nM
Fc1cccc(CNc2n[nH]c3ccc(-c4cn(Cc5ccccc5)nn4)cc23)c1 CHEMBL3910678 Ki 38.0 nM
O=C1NC(NCc2cccc(Cl)c2)=N/C1=C\c1c[nH]c2ncccc12 CHEMBL526657 IC50 39.0 nM
NC(=O)c1cc(-c2ccncc2)[nH]c1-c1ccccc1[N+](=O)[O-] CHEMBL1270425 IC50 39.0 nM
NC(=O)c1cc(-c2ccnc(N)n2)[nH]c1-c1ccsc1 CHEMBL1269729 IC50 39.0 nM
NS(=O)(=O)c1cccc(Nc2ncc3ccn(-c4ccccc4)c3n2)c1 CHEMBL1988163 pKi 39.81 nM
CN(C)c1cc2sncc2cc1NC(=O)C(=O)O CHEMBL1997023 pKi 39.81 nM
O=c1nc(-c2cc3c(Oc4ccc(I)cc4)cncc3s2)[nH]o1 CHEMBL497151 pKi 39.81 nM
CCCCOc1ncnc2[nH]cc(-c3ccccc3)c12 CHEMBL1996817 pKi 39.81 nM
O=c1nc(-c2ccc3[nH]ncc3c2)cc(-c2ccc(N3CCNCC3)cc2)[nH]1 CHEMBL501732 IC50 40.0 nM
CCn1c(-c2ccnc(N)n2)cc(C(N)=O)c1-c1ccccc1 CHEMBL1270924 IC50 40.0 nM
CCCCNc1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12 CHEMBL3925088 Ki 40.0 nM
Clc1ccnc2[nH]c(-c3ccc(N4CCNCC4)cc3)cc12 CHEMBL4084410 IC50 40.0 nM
NC(=O)N(Cc1ccccc1)c1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3C3CC3)cc12 CHEMBL3975457 Ki 41.0 nM
O=c1[nH]c([C@@H]2CCCCN2)nc2cc(-c3c[nH]nc3C(F)(F)F)sc12 CHEMBL4570191 IC50 41.0 nM
CC(C)n1c(-c2ccnc(N)n2)cc2c1CCNC2=O CHEMBL251246 IC50 42.0 nM
O=C1N[C@@H](COCc2ccccc2)Cc2[nH]c(-c3ccncc3)cc21 CHEMBL495539 IC50 44.0 nM
NC(=O)c1cc(-c2ccncc2)[nH]c1-c1cccc([N+](=O)[O-])c1 CHEMBL1270426 IC50 44.0 nM
Cc1c(-c2ccncc2)[nH]c2c1C(=O)NCC2 CHEMBL398261 IC50 45.0 nM
CCNC1=N/C(=C\c2c[nH]c3ncccc23)C(=O)N1 CHEMBL498716 IC50 45.0 nM
c1ccc(CNc2n[nH]c3ccc(-c4nnn(Cc5ccccc5)c4C4CC4)cc23)cc1 CHEMBL3971536 Ki 46.0 nM
Nc1nccc(-c2cc3c(n2CCCC(F)(F)F)CCNC3=O)n1 CHEMBL400271 IC50 47.0 nM
Cc1ccc(C2=N/C(=C\c3c[nH]c4ncccc34)C(=O)N2)cc1 CHEMBL497062 IC50 47.0 nM
O=C1NC(N2CCOCC2)=N/C1=C\c1c[nH]c2ncccc12 CHEMBL497255 IC50 47.0 nM
O=C1NC(c2ccccc2)=N/C1=C\c1c[nH]c2ncccc12 CHEMBL524830 IC50 50.0 nM
Cc1cccc(CNC2=N/C(=C\c3c[nH]c4ncccc34)C(=O)N2)c1 CHEMBL505340 IC50 50.0 nM
c1ccc(Cn2cc(-c3ccc4[nH]nc(-c5cn(Cc6ccccc6)nn5)c4c3)nn2)cc1 CHEMBL1964288 pKi 50.12 nM
O=c1cc(-c2ccc(F)cc2)[nH]c2c(-c3ccc(F)cc3)cnn12 CHEMBL2004443 pKi 50.12 nM
O=C(O)c1ccccc1Nc1ccnc(NCc2ccccc2)n1 CHEMBL244627 pKi 50.12 nM
Fc1ccc(Nc2ncnc(Nc3ccc4cn[nH]c4c3)n2)cc1 CHEMBL1995201 pKi 50.12 nM
COc1ccc(C=C2SC(=Nc3ccccc3)NC2=O)cc1O CHEMBL2000354 pKi 50.12 nM
CC(C)Cc1cc(-c2ccc3[nH]nc(N)c3c2)on1 CHEMBL1966343 pKi 50.12 nM
Fc1ncccc1[C@H](Nc1nnc(-c2c[nH]c3ncccc23)o1)C1CC1 CHEMBL3093076 IC50 51.0 nM
Nc1nccc(-c2cc3c([nH]2)C[C@H](COCc2ccccc2)NC3=O)n1 CHEMBL522890 IC50 52.0 nM
NC(=O)c1c(-c2ccccc2)[nH]c(-c2ccnc(N)n2)c1I CHEMBL1270620 IC50 52.0 nM
COc1ccc(CNc2n[nH]c3ccc(-c4cn(Cc5ccccc5)nn4)cc23)cc1 CHEMBL3980762 Ki 52.0 nM
c1ccc(Cn2nncc2-c2ccc3[nH]ncc3c2)cc1 CHEMBL3976347 Ki 52.3 nM
NC(=O)c1cc(-c2ccnc(Nc3ccccc3)n2)[nH]c1-c1ccccc1 CHEMBL1270324 IC50 53.0 nM
O=C1NC(NCc2cccc(Br)c2)=N/C1=C\c1c[nH]c2ncccc12 CHEMBL500159 IC50 55.0 nM
NC(=O)c1cc(-c2ccncc2)[nH]c1-c1cccc(Br)c1 CHEMBL1270123 IC50 56.0 nM
Fc1ccc(Cn2cc(-c3ccc4[nH]ncc4c3)nn2)cc1 CHEMBL1682352 Ki 56.3 nM
COc1cccc(-c2[nH]c(-c3ccncc3)cc2C(N)=O)c1 CHEMBL1270326 IC50 58.0 nM
CCCC(=O)Nc1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12 CHEMBL1977223 Ki 58.0 nM
O=C1NC(c2cccnc2)=N/C1=C\c1c[nH]c2ncccc12 CHEMBL450749 IC50 60.0 nM
Cc1ccc(-c2[nH]c(-c3ccncc3)cc2C(N)=O)cc1 CHEMBL1270229 IC50 60.0 nM
Fc1cnccc1[C@H](Nc1nnc(-c2c[nH]c3ncccc23)o1)C1CC1 CHEMBL3093077 IC50 60.0 nM
N#Cc1ccnc2[nH]c(-c3ccc(N4CCNCC4)cc3)cc12 CHEMBL4074103 IC50 60.0 nM
Cc1n[nH]c2ccc(-c3cncc(OCCNS(C)(=O)=O)c3)cc12 CHEMBL1967704 pKi 63.1 nM
Fc1cccc(-c2c[nH]c3ncccc23)c1 CHEMBL1993648 pKi 63.1 nM
Cc1cccc(Nc2nc(NC3CCCCC3N)cnc2C(N)=O)c1 CHEMBL1974328 pKi 63.1 nM
O=c1cc(-c2cccc(F)c2)[nH]c2c(-c3ccc(F)cc3)cnn12 CHEMBL2004156 pKi 63.1 nM
c1ccc(Cc2cn(-c3ccc4[nH]ncc4c3)nn2)cc1 CHEMBL1682341 pKi 63.1 nM
O=c1[nH]c2sccc2c2nc(-c3ccncc3)nn12 CHEMBL1968151 pKi 63.1 nM
CC1(C)Cc2[nH]c(-c3ccnc(N)n3)cc2C(=O)N1 CHEMBL495556 IC50 64.0 nM
O=C1NC(NCC2CCCCC2)=N/C1=C\c1c[nH]c2ncccc12 CHEMBL498543 IC50 64.0 nM
N#Cc1ccc(CNc2n[nH]c3ccc(-c4cn(Cc5ccccc5)nn4)cc23)cc1 CHEMBL3917330 Ki 65.0 nM
CC1CN(C2=N/C(=C\c3c[nH]c4ncccc34)C(=O)N2)CCO1 CHEMBL522411 IC50 66.0 nM
Nc1nccc(-n2ccc3ccc(Cl)cc32)n1 CHEMBL2334964 IC50 66.0 nM
CCn1c(-c2ccncc2)cc2c1CCNC2=O CHEMBL250870 IC50 67.0 nM
NC(=O)c1cc(-c2c[nH]c3ncccc23)cc(N[C@H]2CC[C@H](O)CC2)n1 CHEMBL2322676 Ki 67.0 nM
Cc1n[nH]cc1-c1cc2nc(CC3CCCC3)[nH]c(=O)c2s1 CHEMBL4080673 IC50 67.0 nM
NC(=O)c1cc(-c2ccnc(N)n2)[nH]c1-c1csc2ccccc12 CHEMBL1271234 IC50 68.0 nM
Cn1cc(-c2[nH]c(-c3ccnc(N)n3)cc2C(N)=O)c2ccccc21 CHEMBL1270619 IC50 68.0 nM
Nc1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3-c3cccc(N4CCOCC4)c3)cc12 CHEMBL3936503 Ki 68.0 nM
CCCN(C(N)=O)c1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12 CHEMBL3951439 Ki 68.0 nM
O=c1[nH]c([C@H]2CCCN2)nc2c1oc1ccc(Br)cc12 CHEMBL2030394 IC50 70.0 nM
c1ccc([C@H](Nc2nnc(-c3c[nH]c4ncccc34)o2)C2CC2)cc1 CHEMBL3093074 IC50 71.0 nM
NC(=O)c1cc(-c2ccncc2)[nH]c1-c1ccc(Br)cc1 CHEMBL1270124 IC50 73.0 nM
N#Cc1ccc2ccn(-c3ccnc(N)n3)c2c1 CHEMBL2334966 IC50 75.0 nM
O=c1[nH]cnc2c1oc1ccc(Cl)cc12 CHEMBL1992323 pKi 79.43 nM
OCCc1ccc(Nc2ncnc3[nH]cc(-c4ccccc4)c23)cc1 CHEMBL1998773 pKi 79.43 nM
COc1cc(C=C2SC(=Nc3ccccc3)NC2=O)ccc1O CHEMBL1970522 pKi 79.43 nM
CCn1c(-c2nonc2N)nc2cnc(Oc3cccc(NC(=O)c4ccc(OCCN5CCOCC5)cc4)c3)cc21 CHEMBL220241 pKi 79.43 nM
COC(=O)c1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12 CHEMBL3902893 Ki 81.1 nM
NC(=O)c1cc(-c2ccnc(N)n2)[nH]c1-c1ccc2sccc2c1 CHEMBL1271333 IC50 82.0 nM
Nc1nccc(-n2ccc3ccc([N+](=O)[O-])cc32)n1 CHEMBL2348174 IC50 82.0 nM
O=C1NC(NCc2ccc(Cl)cc2)=N/C1=C\c1c[nH]c2ncccc12 CHEMBL498446 IC50 86.0 nM
Cn1c(-c2ccnc(N)n2)cc2c1CCNC2=O CHEMBL398626 IC50 88.0 nM
Cn1c(-c2[nH]c(-c3ccnc(N)n3)cc2C(N)=O)cc2ccccc21 CHEMBL1270618 IC50 90.0 nM
Clc1ccccc1CNc1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3C3CC3)cc12 CHEMBL3960514 Ki 93.0 nM
CCc1ccc(-c2cc(-c3ccc4[nH]ncc4c3)nc(=O)[nH]2)cc1 CHEMBL501731 IC50 100.0 nM
O=C1NCCc2[nH]c(-c3ccnc(C=Cc4ccccc4)c3)cc21 CHEMBL1997129 pKi 100.0 nM
COc1cc(C=C2SC(=S)NC2=O)ccc1O CHEMBL1973098 pKi 100.0 nM
N#Cc1cccc(Nc2ncnc(Nc3ccc(F)cc3)n2)c1 CHEMBL1974582 pKi 100.0 nM
Cc1n[nH]c2ccc(-c3cncc(OCCN)c3)cc12 CHEMBL1967887 pKi 100.0 nM
CS(=O)(=O)N(Cc1ccc2[nH]c(=O)c3cccn3c2c1)C1CC1 CHEMBL1978448 pKi 100.0 nM
NC(=O)c1ccc(-c2ccncc2)cc1NCc1ccccc1 CHEMBL2001477 pKi 100.0 nM
NC(=O)c1ccc(-c2c[nH]c3nc(N)nc(NCc4c(F)cccc4F)c23)cc1 CHEMBL1999860 pKi 100.0 nM
COCCN(CCOC)c1nc(OC)cc(-c2c[nH]c3ncccc23)n1 CHEMBL2003856 pKi 100.0 nM
O=C1Cc2c([nH]c3ccc(Br)cc23)-c2ccccc2N1 CHEMBL296586 pKi 100.0 nM
Nc1nccc(-n2cc(-c3ccccc3)c3cnccc32)n1 CHEMBL2348164 IC50 104.0 nM
CC1CCN(C2=N/C(=C\c3c[nH]c4ncccc34)C(=O)N2)CC1 CHEMBL497256 IC50 105.0 nM
O=c1nc(-c2ccc3[nH]ncc3c2)cc(-c2cccc(C(F)(F)F)c2)[nH]1 CHEMBL502538 IC50 110.0 nM
O=C(Nc1nn(C(=O)c2ccccc2)c2ccc(-c3nnn(Cc4ccccc4)c3C3CC3)cc12)c1ccccc1 CHEMBL3966295 Ki 110.0 nM
NC(=O)c1cc(-c2ccnc(N)n2)[nH]c1-c1cc2ccccc2s1 CHEMBL1271233 IC50 114.0 nM
CC(=O)Nc1cnc2[nH]cc(/C=C3\N=C(NCc4ccccc4)NC3=O)c2c1 CHEMBL525013 IC50 116.0 nM
NC(=O)c1cc(-c2ccncc2)[nH]c1-c1ccc([N+](=O)[O-])cc1 CHEMBL1270518 IC50 117.0 nM
CN1CCC(n2c(-c3ccnc(N)n3)cc3c2CCNC3=O)CC1 CHEMBL400475 IC50 120.0 nM
Nc1nccc(-n2cc(-c3ccoc3)c3cnccc32)n1 CHEMBL2348160 IC50 120.0 nM
CCS(=O)(=O)Nc1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3C3CC3)cc12 CHEMBL3941943 Ki 120.0 nM
c1ccc(CNc2n[nH]c3ccc(-c4cn(Cc5ccccc5)nn4)cc23)cc1 CHEMBL3985842 Ki 120.0 nM
Cc1cc(-c2ccc3c(c2)Nc2ccccc2NC3=O)ccn1 CHEMBL1981511 pKi 125.89 nM
NC(=O)c1ccc(-c2ccncc2)cc1N1CCCC1 CHEMBL1986722 pKi 125.89 nM
O=C1NCCc2[nH]c(-c3ccnc(Cl)c3)cc21 CHEMBL226232 pKi 125.89 nM
O=c1[nH]cnc2c1sc1c(Cl)ccc(Cl)c12 CHEMBL583144 pKi 125.89 nM
CC(C)Nc1c(-c2ccc3[nH]ncc3c2)nc2ncccn12 CHEMBL1682553 pKi 125.89 nM
Fc1ccc(Nc2ncnc(Nc3ccc4[nH]ncc4c3)n2)cc1 CHEMBL1971556 pKi 125.89 nM
NC(=O)Cn1cc(-c2cc(-c3cc4ccccc4s3)c3[nH]ncc3c2)c2nc(N)ncc21 CHEMBL1985095 pKi 125.89 nM
O=C1Nc2ccc3ncsc3c2C1=CNc1ccc(S(=O)(=O)Nc2ccccn2)cc1 CHEMBL1973540 pKi 125.89 nM
Cc1cccc(Nc2nccc(Nc3c(NC(C)C(C)(C)C)c(=O)c3=O)n2)c1 CHEMBL1969523 pKi 125.89 nM
c1cc2[nH]ncc2cc1-c1cn(CC2CCOCC2)nn1 CHEMBL1969843 pKi 125.89 nM
COc1ccccc1-c1[nH]c(-c2ccncc2)cc1C(N)=O CHEMBL1270325 IC50 126.0 nM
O=C1NC(NCc2ccc(Br)cc2)=N/C1=C\c1c[nH]c2ncccc12 CHEMBL500160 IC50 127.0 nM
O=C1NC(NCC23CC4CC(CC(C4)C2)C3)=N/C1=C\c1c[nH]c2ncccc12 CHEMBL498544 IC50 128.0 nM
O=C1NC(NCc2ccccc2)=N/C1=C\c1c[nH]c2ncc([N+](=O)[O-])cc12 CHEMBL498752 IC50 130.0 nM
Fc1ccccc1[C@H](Nc1nnc(-c2c[nH]c3ncncc23)o1)C1CC1 CHEMBL3093078 IC50 130.0 nM
Cc1n[nH]cc1-c1cc2nc(C34CC(CN3)C4)[nH]c(=O)c2s1 CHEMBL4436649 IC50 130.0 nM
N#Cc1ccccc1-c1[nH]c(-c2ccncc2)cc1C(N)=O CHEMBL1270519 IC50 131.0 nM
NC(=O)c1cc(-c2ccnc(N)c2)[nH]c1-c1ccccc1 CHEMBL1271335 IC50 136.0 nM
Nc1nccc(-c2cc3c(n2CCO)CCNC3=O)n1 CHEMBL250884 IC50 138.0 nM
Cn1c(-c2ccnc(N)n2)cc(C(N)=O)c1-c1ccccc1 CHEMBL1270923 IC50 140.0 nM
CC(C)[C@@H](Nc1nnc(-c2c[nH]c3ncccc23)o1)c1ccccc1 CHEMBL3093073 IC50 140.0 nM
Clc1ccc(CNc2n[nH]c3ccc(-c4cn(Cc5ccccc5)nn4)cc23)cc1 CHEMBL3919634 Ki 140.0 nM
O=c1nc(-c2ccc3[nH]ncc3c2)cc(-c2cccc(F)c2)[nH]1 CHEMBL502269 IC50 150.0 nM
CC[C@@H](Nc1nnc(-c2c[nH]c3ncccc23)o1)c1ccccc1 CHEMBL3093072 IC50 150.0 nM
Nc1nccc(-n2ccc3ccc(F)cc32)n1 CHEMBL2348175 IC50 156.0 nM
O=C1NCCCc2[nH]c(-c3ccncc3)cc21 CHEMBL250869 IC50 158.0 nM
NC(=O)c1ccc(-c2ccncc2)cc1NCc1cccc(F)c1 CHEMBL1982982 pKi 158.49 nM
O=c1nc(-c2ccccc2)cc(-c2ccncc2)[nH]1 CHEMBL1998834 pKi 158.49 nM
O=C1NCCc2c1cc(-c1ccncc1)n2CC(F)(F)F CHEMBL248174 IC50 160.0 nM
Nc1nccc(-n2cc(-c3cccc(Cl)c3)c3cnccc32)n1 CHEMBL2348157 IC50 160.0 nM
Nc1nccc(-n2cc(C3=CCOCC3)c3cnccc32)n1 CHEMBL2348158 IC50 160.0 nM
Nc1nccc(-n2cc(-c3cccnc3)c3cnccc32)n1 CHEMBL2348162 IC50 160.0 nM
Cc1ccc(CNC2=N/C(=C\c3c[nH]c4ncccc34)C(=O)N2)cc1 CHEMBL498275 IC50 162.0 nM
Cc1cccc(-c2[nH]c(-c3ccncc3)cc2C(N)=O)c1 CHEMBL1270228 IC50 162.0 nM
O=C1NCCc2[nH]c(-c3ncnc4[nH]cnc34)cc21 CHEMBL254390 IC50 178.0 nM
O=C1CN(CC(=O)Nc2n[nH]c3ccc(-c4cn(Cc5ccccc5)nn4)cc23)CCN1 CHEMBL3947423 Ki 180.0 nM
O=C1CCCN1c1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12 CHEMBL3937279 Ki 180.0 nM
c1ccc(-n2cc(-c3ccc4[nH]ncc4c3)nn2)cc1 CHEMBL3928683 Ki 192.0 nM
NC(=O)c1cc(-c2ccncc2)[nH]c1Br CHEMBL1269091 IC50 197.0 nM
c1cc(NC2CCCCC2)nc(Nc2ccc3[nH]ncc3c2)n1 CHEMBL1964648 pKi 199.53 nM
Cc1c[nH]c2nccc(Oc3c(F)cc(Nc4cc(Cl)nc(N)n4)cc3F)c12 CHEMBL1971943 pKi 199.53 nM
Cc1nc(N)sc1-c1ccnc(Nc2ccc(N3CCOCC3)cc2)n1 CHEMBL482967 pKi 199.53 nM
N#CC1=C(N)n2c(sc(=Cc3ccco3)c2=O)=C(C(N)=O)C1c1ccco1 CHEMBL1989805 pKi 199.53 nM
CCc1c(-c2ccc(C(C)(C)O)cc2)[nH]c2nccnc12 CHEMBL1976420 pKi 199.53 nM
Clc1cc(-c2c[nH]c3ncccc23)ncn1 CHEMBL1972988 pKi 199.53 nM
NC(=O)c1cc(-c2ccncc2)[nH]c1-c1ccncc1 CHEMBL1269089 IC50 200.0 nM
O=C1NCCc2oc(-c3ccncc3)cc21 CHEMBL250692 IC50 201.0 nM
CC(C)(C)C1CCC(NC2=N/C(=C\c3c[nH]c4ncccc34)C(=O)N2)CC1 CHEMBL502837 IC50 207.0 nM
N[C@@H]1CCN(Cc2nc3c(oc4ccc(Br)cc43)c(=O)[nH]2)C1 CHEMBL2030388 IC50 207.0 nM
O=C1NCCn2nc(-c3ccncc3)cc21 CHEMBL250691 IC50 210.0 nM
Cc1n[nH]cc1-c1cc2c(s1)C(=O)NC(C)(CC(F)(F)F)N2C CHEMBL4214023 IC50 210.0 nM
N#Cc1cccc(-c2[nH]c(-c3ccncc3)cc2C(N)=O)c1 CHEMBL1270520 IC50 216.0 nM
O=C1NCCc2[nH]c(-c3ccnc(NCc4ccccc4)n3)cc21 CHEMBL249254 IC50 220.0 nM
c1ccc(Cn2cc(-c3ccc4[nH]nc(NCCN5CCOCC5)c4c3)nn2)cc1 CHEMBL3933614 Ki 220.0 nM
O=C(c1cccc(Cl)c1)c1c(-c2ccc3[nH]ncc3c2)nnn1CC1CCOCC1 CHEMBL3959053 Ki 229.0 nM
CN1CCN(c2n[nH]c3ccc(-c4cn(Cc5ccccc5)nn4)cc23)CC1 CHEMBL3960629 Ki 230.0 nM
Nc1cnc2[nH]cc(/C=C3\N=C(NCc4ccccc4)NC3=O)c2c1 CHEMBL498753 IC50 238.0 nM
CN(C)CC(=O)Nc1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12 CHEMBL1965631 Ki 242.0 nM
CCCCCCCNC1=N/C(=C\c2c[nH]c3ncccc23)C(=O)N1 CHEMBL519024 IC50 247.0 nM
Nc1nccc(-n2cc(-c3ccncc3)c3cnccc32)n1 CHEMBL2348161 IC50 250.0 nM
Fc1ccc2c(-c3nnc(N[C@@H](c4cccnc4F)C4CC4)o3)c[nH]c2n1 CHEMBL3093079 IC50 250.0 nM
O=c1cc(-c2ccccc2)nc(NC2CCCCC2)[nH]1 CHEMBL1958399 pKi 251.19 nM
COc1cc(C=C2SC(=O)NC2=O)ccc1O CHEMBL2003286 pKi 251.19 nM
CN(C)CCNC(=O)c1ccc(-c2ccnc(Nc3cccc(F)c3)n2)cc1 CHEMBL1987881 pKi 251.19 nM
OCC(CO)Nc1ncnc2[nH]cc(-c3ccccc3)c12 CHEMBL1992922 pKi 251.19 nM
Cc1cc(Cl)ccc1NC(=S)NNC(=O)C(O)(c1ccccc1)c1ccccc1 CHEMBL1988173 pKi 251.19 nM
COc1cc(C=C(C#N)c2nc3ccccc3[nH]2)c(Br)cc1O CHEMBL1994241 pKi 251.19 nM
NC(COc1cncc(-c2ccc3c(c2)C(=Cc2ccco2)C(=O)N3)c1)Cc1c[nH]c2ccccc12 CHEMBL2001751 pKi 251.19 nM
Nc1n[nH]c2cccc(-c3ccc(NC(=O)Nc4cc(C(=O)O)ccc4F)cc3)c12 CHEMBL1993722 pKi 251.19 nM
c1ccc(Cn2cc(-c3ccc4[nH]nc(-c5nccs5)c4c3)nn2)cc1 CHEMBL3918627 Ki 258.0 nM
CCCNc1nccc(-c2cc3c([nH]2)CCNC3=O)n1 CHEMBL251283 IC50 259.0 nM
O=C(Nc1nccc(-c2cc3c([nH]2)CCNC3=O)n1)c1ccccc1 CHEMBL400596 IC50 262.0 nM
NC(=O)c1cc(-c2ccnc(N)n2)[nH]c1-c1ccc2ccccc2c1 CHEMBL1271129 IC50 269.0 nM
NC(=O)c1c[nH]c(-c2ccncc2)c1 CHEMBL1269092 IC50 280.0 nM
O=C(CC1CNC(=O)c2cc(-c3cn[nH]c3)cn21)NCc1cccc(F)c1 CHEMBL3298823 IC50 284.0 nM
Nc1nccc(-c2cc3c(n2Cc2ccccc2)CCNC3=O)n1 CHEMBL251282 IC50 290.0 nM
Cc1n[nH]cc1-c1cc2c(s1)C(=O)NC1(CCCCC1)N2 CHEMBL4216005 IC50 290.0 nM
NC(=O)c1cc(-c2ccncc2)[nH]c1C1CCCCC1 CHEMBL1269056 IC50 293.0 nM
Oc1cccc(-c2c[nH]c3ncccc23)c1 CHEMBL1972752 pKi 316.23 nM
NC(=O)c1sc2c(Br)ccc(Cl)c2c1N CHEMBL1998611 pKi 316.23 nM
O=C(O)c1c2c(nc3ccccc13)C(=C1CCCC1)CC2 CHEMBL1996831 pKi 316.23 nM
CNC(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCOCC3)cc2OC)ncc1Cl CHEMBL458997 pKi 316.23 nM
NC(=O)c1sc2ccc(Cl)c(Cl)c2c1NC(=O)c1ccc(Cl)cc1 CHEMBL2003271 pKi 316.23 nM
CC(=O)NCC(=O)N1C2CCC1c1cc(Nc3ncc(C(F)(F)F)c(NC4CCC4)n3)ccc12 CHEMBL1983111 pKi 316.23 nM
O=S(=O)(O)c1ccc(NCc2ccc3c(c2)OCO3)c2c(O)cccc12 CHEMBL2004544 pKi 316.23 nM
NC(=O)c1ccc(-c2c[nH]c3nccc(Cl)c23)cc1 CHEMBL1982711 pKi 316.23 nM
COc1cc(C=C(C#N)c2nc3cc(C)ccc3[nH]2)c(Br)cc1O CHEMBL2000345 pKi 316.23 nM
CC(=O)Nc1nccc(-c2cc3c([nH]2)CCNC3=O)n1 CHEMBL250453 IC50 323.0 nM
NC(=O)c1cc(-c2ccnc(N)n2)[nH]c1-c1cccc2ccccc12 CHEMBL1271128 IC50 325.0 nM
Nc1nccc(-n2cc(-c3ccc(Cl)cc3)c3cnccc32)n1 CHEMBL2348155 IC50 330.0 nM
O=S(=O)(Nc1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3-c3ccccc3)cc12)c1ccccc1 CHEMBL3986570 Ki 340.0 nM
O=c1nc(-c2ccc3[nH]ncc3c2)cc(-c2ccc(OCc3ccccc3)cc2)[nH]1 CHEMBL501462 IC50 350.0 nM
Nc1nccc(-n2ccc3ccc(Br)cc32)n1 CHEMBL2334965 IC50 350.0 nM
c1ccc(Cn2cc(-c3ccc4[nH]nc(NCC5CCCCC5)c4c3)nn2)cc1 CHEMBL3956257 Ki 350.0 nM
Cc1n[nH]cc1-c1cc2nc(CN(C)C)[nH]c(=O)c2s1 CHEMBL4062209 IC50 350.0 nM
Nc1nccc(-n2ccc3cnc(Cl)cc32)n1 CHEMBL2346665 IC50 360.0 nM
C[C@@H](Nc1nnc(-c2c[nH]c3ncccc23)o1)c1ccccc1 CHEMBL3093070 IC50 370.0 nM
Cn1ncc2cc(Nc3ccnc(N)n3)ccc21 CHEMBL1975175 pKi 398.11 nM
CC(N)COc1cnc(Cl)c(C=Cc2ccncc2)c1 CHEMBL1993548 pKi 398.11 nM
OCCCNc1ncnc2[nH]cc(-c3ccccc3)c12 CHEMBL2000071 pKi 398.11 nM
c1cnc2nc(-c3ccc4[nH]ncc4c3)cn2c1 CHEMBL1682540 pKi 398.11 nM
O=C1Cc2c([nH]c3ccc([N+](=O)[O-])cc23)-c2ccccc2N1 CHEMBL50894 pKi 398.11 nM
NC(COc1cncc(C=Cc2ccncc2)c1)Cc1c[nH]c2ccccc12 CHEMBL1974935 pKi 398.11 nM
CN(C)C(=O)Nc1ccc2nc(-c3ccco3)c(-c3ccco3)nc2c1 CHEMBL1986328 pKi 398.11 nM
Cn1c(-c2ccncc2)cc2c1CCNC2=O CHEMBL252724 IC50 404.0 nM
NC(=O)c1cc(-c2ccnc(N)n2)sc1-c1ccccc1 CHEMBL1269909 IC50 410.0 nM
CCS(=O)(=O)Nc1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12 CHEMBL3923726 Ki 410.0 nM
NC(=O)c1cc(-c2ccnc(N)n2)[nH]c1-c1ccccn1 CHEMBL1271127 IC50 412.0 nM
Nc1n[nH]c2ccc(-c3nnn(Cc4ccc(C(F)(F)F)cc4)c3-c3ccc(F)cc3)cc12 CHEMBL3935067 Ki 430.0 nM
NC(=O)c1cc(-c2ccnc(N)n2)n(CCO)c1-c1ccccc1 CHEMBL1271022 IC50 456.0 nM
CC(C)c1[nH]c(-c2ccncc2)cc1C(N)=O CHEMBL1269784 IC50 463.0 nM
CC(C)N(C)C(=O)c1c(-c2ccc3[nH]ncc3c2)nnn1Cc1ccccc1 CHEMBL1969561 Ki 473.0 nM
CCc1[nH]c(-c2ccncc2)cc1C(N)=O CHEMBL1269783 IC50 482.0 nM
Cn1ccnc1-c1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12 CHEMBL3964275 Ki 489.0 nM
O=C(CNC1CCCCC1)Nc1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12 CHEMBL3960171 Ki 500.0 nM
CC(=O)Nc1c(C(N)=O)sc2ccc(Cl)c(Cl)c12 CHEMBL1973142 pKi 501.19 nM
CCN(CC)C(=O)Nc1ccc2nc(-c3ccco3)c(-c3ccco3)nc2c1 CHEMBL1983195 pKi 501.19 nM
Oc1cncc2nc(-c3ccncc3)ccc12 CHEMBL1976673 pKi 501.19 nM
Cc1ccccc1-c1c(C(=O)O)n(CCCOc2cccc3ccccc23)c2ccccc12 CHEMBL1987793 pKi 501.19 nM
O=c1cc(-c2ccncc2)[nH]n1-c1ccc([N+](=O)[O-])cc1 CHEMBL3145311 pKi 501.19 nM
CC(C)N(C(=O)Nc1ccc2nc(-c3ccco3)c(-c3ccco3)nc2c1)C(C)C CHEMBL2006156 pKi 501.19 nM
c1cnc2nc(-c3ccc4[nH]ncc4c3)c(NC3CCCCC3)n2c1 CHEMBL1682552 pKi 501.19 nM
CNS(=O)(=O)c1ccccc1Nc1nc(Nc2cc(N3CCN(C(C)=O)CC3)ccc2OC)ncc1Br CHEMBL1971029 pKi 501.19 nM
NCCC(C(=O)Nc1ccc2[nH]ncc2c1)c1ccc(Cl)c(Cl)c1 CHEMBL1998121 pKi 501.19 nM
O=c1c(NCc2ccccc2F)c(Nc2ccncc2)c1=O CHEMBL1982361 pKi 501.19 nM
O=C(Nc1c[nH]nc1-c1nc2ccc(CN3CCOCC3)cc2[nH]1)NC1CC1 CHEMBL495727 Kd apparent 511.0 nM
Cc1[nH]c(-c2ccncc2)cc1C(N)=O CHEMBL1269782 IC50 516.0 nM
NCCn1c(-c2ccnc(N)n2)cc(C(N)=O)c1-c1ccccc1 CHEMBL1271023 IC50 530.0 nM
c1ccc(Cn2cc(-c3ccc4[nH]nc(NCC5CC5)c4c3)nn2)cc1 CHEMBL3946172 Ki 570.0 nM
Nc1nccc(-n2cc(-c3cc[nH]n3)c3cnccc32)n1 CHEMBL2348159 IC50 580.0 nM
Fc1cccc(CNc2nnc(-c3c[nH]c4ncccc34)o2)c1 CHEMBL3093064 IC50 580.0 nM
c1ccc(Cn2cc(-c3ccc4[nH]nc(N5CCOCC5)c4c3)nn2)cc1 CHEMBL3979260 Ki 630.0 nM
Cc1nc2ccc(NS(=O)(=O)c3ccc(N)cc3)cc2nc1C CHEMBL2006263 pKi 630.96 nM
COc1cc2c(cc1Nc1nc(Nc3cccc(F)c3C(N)=O)c3cc[nH]c3n1)N(C(=O)CN(C)C)CC2 CHEMBL461876 pKi 630.96 nM
Cc1ccc(C(=O)Nc2c(C(N)=O)sc3ccc(Cl)c(Cl)c23)cc1 CHEMBL1965131 pKi 630.96 nM
NC(=O)c1cccc(-c2cnc3[nH]cc(-c4ccccc4)c3c2)c1 CHEMBL1982957 pKi 630.96 nM
NC(=O)c1cn(-c2ccc(O)cc2Cl)c2cc(-c3ccncc3)ccc2c1=O CHEMBL340384 pKi 630.96 nM
CC(Nc1c(Nc2ccncc2)c(=O)c1=O)C(C)(C)C CHEMBL1986186 pKi 630.96 nM
Cc1cnc(Nc2cccc(S(N)(=O)=O)c2)nc1Nc1ccc(OCC(N)=O)cc1 CHEMBL1988838 pKi 630.96 nM
CC(=O)N(c1ccncc1)c1c(NC(C)C(C)(C)C)c(=O)c1=O CHEMBL2005899 pKi 630.96 nM
CN(C)C(=O)c1c(-c2ccc3[nH]ncc3c2)nnn1Cc1ccccc1 CHEMBL1996111 pKi 630.96 nM
CC(C)CNc1nccc(-c2cc3c([nH]2)CCNC3=O)n1 CHEMBL251469 IC50 636.0 nM
NC(=O)c1cc(-c2ccnc(N)n2)oc1-c1ccccc1 CHEMBL1269908 IC50 640.0 nM
O=C1NCCc2[nH]c(-c3ccnc(NCC4CCCCC4)n3)cc21 CHEMBL251472 IC50 655.0 nM
NC(=O)c1cc(-c2ccnc(N)n2)[nH]c1-c1cc2ccccc2o1 CHEMBL1271232 IC50 658.0 nM
CN(C)C(=O)c1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12 CHEMBL3902689 Ki 681.0 nM
Fc1ccc(CNc2nnc(-c3c[nH]c4ncccc34)o2)cc1 CHEMBL3093065 IC50 690.0 nM
c1ccc(CNc2nnc(-c3ccc4cnccc4c3)o2)cc1 CHEMBL3093055 IC50 710.0 nM
c1ccc(CNc2nnc(-c3ccc4[nH]ncc4c3)o2)cc1 CHEMBL3093058 IC50 730.0 nM
C#Cc1ccc2ccn(-c3ccnc(N)n3)c2c1 CHEMBL2348171 IC50 760.0 nM
c1ccc(CNc2nnc(-c3c[nH]c4ncccc34)o2)cc1 CHEMBL3093062 IC50 780.0 nM
NCCCn1c(-c2ccnc(N)n2)cc(C(N)=O)c1-c1ccccc1 CHEMBL1271024 IC50 793.0 nM
O=C1CCCN1Cc1ccc2c(c1)[nH]c(=O)c1cccn12 CHEMBL539474 pKi 794.33 nM
Nc1ncnc2c1sc1ncnc(N)c12 CHEMBL1976090 pKi 794.33 nM
S=c1[nH]nc2c3c4c(sc3n3c(=S)[nH]nc3n12)CCC4 CHEMBL1969537 pKi 794.33 nM
NC(=O)c1cc2c(Oc3ccc(Br)cc3)cncc2s1 CHEMBL116070 pKi 794.33 nM
Cc1cc(C)c(C)c(OCCCc2c(C(=O)O)[nH]c3c(-c4ccccc4C)cccc23)c1 CHEMBL1990821 pKi 794.33 nM
CCOC(=O)C1=C(N)n2c(sc(=Cc3cccs3)c2=O)=C(C(N)=O)C1c1cccs1 CHEMBL2004365 pKi 794.33 nM
NC(=O)c1cc2c(-c3ccc(F)cc3)cncc2s1 CHEMBL1974310 pKi 794.33 nM
O=C(NN=Cc1ccc(O)cc1O)Nc1cccc2nsnc12 CHEMBL1999811 pKi 794.33 nM
NC(=O)c1cc(-c2ccncc2)[nH]c1Cc1ccccc1 CHEMBL1269910 IC50 859.0 nM
O=CN1CCc2[nH]c(-c3ccncc3)cc2C1=O CHEMBL398521 IC50 863.0 nM
Nc1nccc(-n2ccc3ccncc32)n1 CHEMBL2348167 IC50 930.0 nM
Nc1nccc(-n2ccc3cnccc32)n1 CHEMBL2348168 IC50 980.0 nM
O=S(=O)(Nc1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3C3CC3)cc12)c1ccc(Cl)cc1 CHEMBL3891467 Ki 980.0 nM
COc1ccc(-c2cc(-c3ccnc(N)c3)nc(=O)[nH]2)c(OC)c1 CHEMBL524866 IC50 1000.0 nM
OC(COc1cncc(C=Cc2ccncc2)c1)Cc1c[nH]c2ccccc12 CHEMBL1993584 pKi 1000.0 nM
CS(=O)(=O)Nc1ccc(-c2ccc3[nH]nc(N)c3c2)cc1 CHEMBL2004892 pKi 1000.0 nM
Oc1c2ccccc2c2c3c(cccc13)N=N2 CHEMBL1725279 pKi 1000.0 nM
NC(Cc1c[nH]c2ccccc12)C(=O)Nc1cncc(C=Cc2ccncc2)c1 CHEMBL1983945 pKi 1000.0 nM
Cc1cc(Nc2ncc(F)c(NC3C4C=CC(C4)C3C(N)=O)n2)ccc1N1CCN(C)CC1 CHEMBL1967878 pKi 1000.0 nM
O=c1[nH]c(CN2CC[C@H](O)C2)nc2c1oc1cc(O)c(Br)cc12 CHEMBL2030383 IC50 1000.0 nM
O=S(=O)(Nc1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3C3CC3)cc12)c1ccccc1 CHEMBL3979653 Ki 1000.0 nM
CN1C(=O)[C@@H](N2CCc3cn(Cc4ccccc4)nc3C2=O)COc2ccccc21 CHEMBL4088216 pIC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3c(nn(Cc4ccccc4)c3Br)C2=O)COc2ccccc21 CHEMBL4549667 pIC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3cn(CC4CCS(=O)(=O)CC4)nc3C2=O)COc2ccccc21 CHEMBL4097778 pIC50 1000.0 nM