NS(=O)(=O)c1ccc(Nc2ncc(C(F)(F)F)c(Nc3ccc4[nH]cnc4c3)n2)cc1 CHEMBL194540 IC50 0.1 nM
CC(=O)N1N=C(c2c(O)c3ccccc3oc2=O)CC1c1ccccc1Cl CHEMBL5176826 Ki 0.35 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL388978 IC50 0.4 nM
O=C1Nc2ccc3ncsc3c2/C1=C/Nc1ccc(S(=O)(=O)NCCOCCO)cc1 CHEMBL1964259 IC50 0.54 nM
CCNCc1cncc(-c2cnc3[nH]nc(-c4nc5cc(F)ccc5[nH]4)c3c2)c1 CHEMBL248713 IC50 0.7 nM
CCNCc1cncc(-c2cnc3[nH]nc(-c4nc5cc(OC)ccc5[nH]4)c3c2)c1 CHEMBL429478 IC50 0.8 nM
C[C@@H]1CNc2c(sc3ccc4ncccc4c23)C(=O)N1 CHEMBL561334 IC50 0.8 nM
FC(F)(F)c1cnc(Nc2ccc3[nH]cnc3c2)nc1Nc1ccccc1Cl CHEMBL194721 IC50 0.9 nM
C[C@@H]1C[C@H]2CN1CCn1nc3c(cccc3c1O)-c1nc3c(cccc3nc1O)O2 CHEMBL215803 IC50 1.0 nM
C[C@@H]1CNc2c(sc3ccc4occc4c23)C(=O)N1 CHEMBL557318 IC50 1.0 nM
CCc1cnn2c(NCc3ccc[n+]([O-])c3)cc(N3CCCC[C@H]3CCO)nc12 CHEMBL2103840 IC50 1.0 nM
CCNCc1cncc(-c2cnc3[nH]nc(-c4nc5cc(F)c(F)cc5[nH]4)c3c2)c1 CHEMBL248712 IC50 1.1 nM
CCN(CC)Cc1cccc2[nH]c(-c3n[nH]c4ncc(-c5cncc6ccccc56)cc34)nc12 CHEMBL249303 IC50 1.8 nM
CC(C)COc1nc(Nc2ccc3[nH]cnc3c2)ncc1C(F)(F)F CHEMBL192216 IC50 2.0 nM
COc1ccc(F)c(F)c1C(=O)c1cnc(NC2CCN(S(C)(=O)=O)CC2)nc1N CHEMBL384304 Ki 2.0 nM
CN[C@H]1CCN(C(=O)c2ccc(Nc3ncc(F)c(-c4cnc(C)n4C(C)C)n3)cc2)C1 CHEMBL455657 IC50 2.0 nM
COc1cc(Nc2ncc(Br)c(N[C@H](C)C(C)(C)O)n2)ccc1S(C)(=N)=O CHEMBL3648115 IC50 2.0 nM
COc1cc(Nc2ncc(Br)c(N[C@H](C)[C@@H](C)O)n2)ccc1S(C)(=N)=O CHEMBL3648111 IC50 2.0 nM
COc1cc(Nc2ncc(Br)c(N[C@H](C)[C@H](C)O)n2)ccc1S(C)(=N)=O CHEMBL3648112 IC50 2.0 nM
COCCN1CCN(Cc2ccc(-c3n[nH]c4c3C(=O)c3c(NC(=O)NN5CCOCC5)cccc3-4)cc2)CC1 CHEMBL3545083 IC50 2.0 nM
CNCc1cncc(-c2cnc3[nH]nc(-c4nc5c(COC)cccc5[nH]4)c3c2)c1 CHEMBL400749 IC50 2.5 nM
NC(=O)c1ccc2c(c1)/C(=N/Nc1ccc(S(N)(=O)=O)cc1)C(=O)N2 CHEMBL410883 IC50 2.8 nM
FC(F)(F)c1cnc(Nc2ccc3[nH]cnc3c2)nc1Nc1cccc(Cl)c1 CHEMBL193922 IC50 3.0 nM
CCNCc1cncc(-c2cnc3[nH]nc(-c4nc5cc(N6CCN(C)CC6)ccc5[nH]4)c3c2)c1 CHEMBL400569 IC50 3.0 nM
CN1CCN(C(=O)c2cc(Nc3ncc4cc(/C=N/O)n(C5CCCC5)c4n3)cn2C)CC1 CHEMBL2029900 IC50 3.0 nM
C[C@@H](O)[C@@H](C)Nc1nc(Nc2ccc(S(=N)(=O)CCO)cc2)ncc1Br CHEMBL3648109 IC50 3.0 nM
CN1C/C=C/CCOc2cccc(c2)-c2ccnc(n2)Nc2cccc(c2)C1 CHEMBL1944698 IC50 3.0 nM
C[C@@H](O)[C@@H](C)Oc1nc(Nc2ccc(S(=O)(=O)CCO)cc2)ncc1C(F)(F)F CHEMBL3644026 IC50 3.0 nM
Cc1cnn2c(NCc3ccc[n+]([O-])c3)cc(N3CCCC[C@@H]3CCO)nc12 CHEMBL4292930 IC50 3.0 nM
CCc1cnn2c(NCc3ccc[n+]([O-])c3)cc(C3CCCC[C@H]3CCO)nc12 CHEMBL5171657 IC50 3.0 nM
CCc1cnn2c(NCc3ccc[n+]([O-])c3)cc(N3CCCC[C@@H]3CCO)nc12 CHEMBL5266005 IC50 3.0 nM
CNC1CC2OC(C)(C1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL1980995 pKi 3.981 nM
CCCC(=O)Nc1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12 CHEMBL1977223 pKi 3.981 nM
FC(F)(F)c1cnc(Nc2ccc3[nH]cnc3c2)nc1Nc1ccc(Cl)cc1 CHEMBL193367 IC50 4.0 nM
Fc1ccc(Nc2nc(Nc3ccc4[nH]cnc4c3)ncc2Br)cc1 CHEMBL195423 IC50 4.0 nM
Cc1ccccc1Oc1nc(Nc2ccc3[nH]cnc3c2)ncc1C(F)(F)F CHEMBL370522 IC50 4.0 nM
Cc1cc(Nc2ncc(Br)c(N[C@H](C)[C@H](C)O)n2)ccc1S(C)(=N)=O CHEMBL3648096 IC50 4.0 nM
Cc1cc(Nc2ncc(Br)c(N[C@H](C)C(C)(C)O)n2)ccc1S(C)(=N)=O CHEMBL3639469 IC50 4.0 nM
C[C@@H](O)[C@@H](C)Oc1nc(Nc2ccc(S(C)(=O)=O)cc2)ncc1C(F)(F)F CHEMBL3644033 IC50 4.0 nM
CN1CC[C@H](c2c(O)cc(O)c3c(=O)cc(/C=C/c4c(Cl)cccc4Cl)oc23)[C@H](O)C1 CHEMBL4079206 IC50 4.9 nM
Nc1nc(Nc2ccc(S(N)(=O)=O)cc2)nc(OCC2CCCCC2)c1N=O CHEMBL318999 IC50 5.0 nM
COc1cc(F)c(F)c(F)c1C(=O)c1cnc(NC2CCN(S(C)(=O)=O)CC2)nc1N CHEMBL213713 Ki 5.0 nM
O=C1Nc2ccc(S(=O)(=O)O)cc2/C1=C1/Nc2ccccc2/C1=N\O CHEMBL440411 IC50 5.0 nM
O=Nc1c(-c2c(O)[nH]c3ccc(I)cc23)[nH]c2ccccc12 CHEMBL337300 IC50 5.0 nM
Cc1ncc(-c2nc(Nc3ccc(C(=O)N4CCCN(C)CC4)cc3)ncc2F)n1C(C)C CHEMBL462192 IC50 5.0 nM
C[C@@H]1CNc2c(sc3ccc4c(c23)CCO4)C(=O)N1 CHEMBL562754 IC50 5.0 nM
Cc1nc2ccccn2c1-c1ccnc(Nc2ccc(OCC(O)CN(C)C)cc2)n1 CHEMBL102926 IC50 5.0 nM
COc1cc(Nc2ncc(Br)c(O[C@H](C)[C@H](C)O)n2)ccc1S(C)(=N)=O CHEMBL3648082 IC50 5.0 nM
C[C@@H](Nc1nc(Nc2ccc(S(=N)(=O)CC3CC3)cc2)ncc1Br)C(C)(C)O CHEMBL3648076 IC50 5.0 nM
C[C@H](Nc1nc(Nc2ccc(S(C)(=N)=O)cc2)ncc1Br)C(C)(C)O CHEMBL3648116 IC50 5.0 nM
CCS(=N)(=O)c1ccc(Nc2ncc(Br)c(N[C@H](C)[C@H](C)O)n2)cc1 CHEMBL3648095 IC50 5.0 nM
C[C@H](O)[C@@H](C)Nc1nc(Nc2ccc(S(=N)(=O)CCO)cc2)ncc1Br CHEMBL3648110 IC50 5.0 nM
C[C@H](O)[C@@H](C)Nc1nc(Nc2ccc(S(C)(=N)=O)cc2)ncc1Br CHEMBL3648117 IC50 5.0 nM
NS(=O)(=O)c1ccc(Nc2nc(OCC3CCCCC3)c3nc[nH]c3n2)cc1 CHEMBL319467 IC50 5.0 nM
C[C@@H](O)[C@@H](C)Oc1nc(Nc2ccc(S(=N)(=O)C3CC3)cc2)ncc1C(F)(F)F CHEMBL4442620 IC50 5.0 nM
O=C(Nc1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12)c1ccccc1 CHEMBL1999931 pKi 5.012 nM
COCc1cccc2[nH]c(-c3n[nH]c4ncc(-c5cncc6ccccc56)cc34)nc12 CHEMBL248891 IC50 5.6 nM
COCCCNS(=O)(=O)c1ccc(Nc2nccc(-c3cnc4ccccn34)n2)cc1 CHEMBL73243 IC50 6.0 nM
Nc1nc(Nc2ccc(S(N)(=O)=O)cc2)nn1C(=O)c1c(F)cccc1F CHEMBL191003 IC50 6.0 nM
Nc1nc(N)c(N=O)c(=O)[nH]1 CHEMBL291324 IC50 6.0 nM
CN1CCN(C(=O)c2cc(Nc3ncc4cc(C#N)n(C5CCCC5)c4n3)cn2C)CC1 CHEMBL2029901 IC50 6.0 nM
NC1CCC(Nc2nccc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1966628 pKi 6.31 nM
COc1cc(-c2ccc3c(c2)Nc2ccc([N+](=O)[O-])cc2NC3=O)ccc1O CHEMBL1995740 pKi 6.31 nM
CN=S(C)(=O)c1ccc(Nc2ncc(Br)c(N[C@H](C)[C@@H](C)O)n2)cc1OC CHEMBL3648113 IC50 7.0 nM
C[C@@H](Nc1nc(Nc2ccc(S(=N)(=O)CCO)cc2)ncc1Br)C(C)(C)O CHEMBL3648107 IC50 7.0 nM
C[C@@H](O)[C@@H](C)Oc1nc(Nc2ccc([S@](=N)(=O)C3CC3)cc2)ncc1C(F)(F)F CHEMBL4282338 IC50 7.0 nM
C/C(Nc1ccc(S(N)(=O)=O)cc1)=C1/C(=O)Nc2ccc(-c3cnco3)cc21 CHEMBL411887 IC50 7.1 nM
CCCNCc1cncc(-c2cnc3[nH]nc(-c4nc5c(COC)cccc5[nH]4)c3c2)c1 CHEMBL400568 IC50 7.4 nM
CCN(CC)c1cc(-c2ccnc(Nc3cccc(S(N)(=O)=O)c3)n2)ccn1 CHEMBL2158853 IC50 7.4 nM
COc1ccc(Nc2nc(Nc3ccc4[nH]cnc4c3)ncc2C(F)(F)F)cc1 CHEMBL372464 IC50 8.0 nM
CCS(=N)(=O)c1ccc(Nc2ncc(Br)c(N[C@H](C)C(C)(C)O)n2)cc1 CHEMBL3648123 IC50 8.0 nM
C[C@@H](O)[C@@H](C)Oc1nc(Nc2ccc(S(=O)(=O)C3CC3)cc2)ncc1C(F)(F)F CHEMBL3644032 IC50 8.0 nM
c1ccc2c(-c3cnc4[nH]nc(-c5nc6cc(N7CCOCC7)ccc6[nH]5)c4c3)cncc2c1 CHEMBL249500 IC50 8.5 nM
CN1CCC(c2c(O)cc(O)c3c2O/C(=C\c2ccc(S(N)(=O)=O)cc2)C3=O)CC1 CHEMBL48362 IC50 9.0 nM
Clc1cccc(Nc2ncc(Br)c(Nc3ccc4[nH]cnc4c3)n2)c1 CHEMBL370728 IC50 9.0 nM
Brc1cnc(Nc2ccc3[nH]cnc3c2)nc1Nc1ccc2c(c1)OCO2 CHEMBL372465 IC50 9.0 nM
CNCc1cncc(-c2cnc3[nH]nc(-c4nc5cc(OC(F)(F)F)ccc5[nH]4)c3c2)c1 CHEMBL400906 IC50 9.0 nM
CN[C@H]1CCN(C(=O)c2ccc(Nc3nccc(-c4cnc(C)n4C(C)C)n3)cc2)C1 CHEMBL460087 IC50 9.0 nM
Cc1cc(Nc2ncc(Br)c(N[C@@H](C)C(C)(C)O)n2)ccc1S(C)(=N)=O CHEMBL3648125 IC50 9.0 nM
C[C@@H](Oc1nc(Nc2ccc(S(C)(=O)=O)cc2)ncc1C(F)(F)F)C(C)(C)O CHEMBL3644034 IC50 9.0 nM
COc1cccc(OC)c1CNC(=O)c1ccc2c(c1)/C(=N/Nc1ccc(S(N)(=O)=O)cc1)C(=O)N2 CHEMBL271136 IC50 9.3 nM
CC(C)C(CO)Nc1nc(NCc2ccccc2O)c2ncn(C(C)C)c2n1 CHEMBL83320 IC50 10.0 nM
NS(=O)(=O)c1ccc(N/N=C2\C(=O)Nc3ccc(-c4cnco4)cc32)cc1 CHEMBL269827 IC50 10.0 nM
FC(F)(F)c1cnc(Nc2ccc3[nH]cnc3c2)nc1Nc1ccc2[nH]cnc2c1 CHEMBL193519 IC50 10.0 nM
N#CNc1ccc(Nc2ncc(C(F)(F)F)c(Nc3ccc4[nH]cnc4c3)n2)cc1NC#N CHEMBL195641 IC50 10.0 nM
CN(C)CCCOc1cc2c(cc1O)c1c3c(c(-c4ccccc4Cl)cc1n2C)C(=O)NC3=O CHEMBL410261 IC50 10.0 nM
O=C(Nc1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12)c1cccc(F)c1 CHEMBL2003638 pKi 10.0 nM
Cn1cc(Nc2ncc3cnn([C@@H]4C[C@H]5C[C@H]5C4)c3n2)cc1C(=O)N1CCC[C@H]1C(N)=O CHEMBL2012408 IC50 10.0 nM
Cn1cc(Nc2ncc3cnn([C@@H]4C[C@H]5C[C@H]5C4)c3n2)cc1C(=O)N1CCC[C@H]1CO CHEMBL2012409 IC50 10.0 nM
C[C@@H](Nc1nc(Nc2ccc(S(C)(=N)=O)cc2)ncc1Br)C(C)(C)O CHEMBL3648072 IC50 10.0 nM
CN1CC[C@H](c2c(O)cc(O)c3c(=O)cc(-c4ccccc4Cl)oc23)[C@H](O)C1 CHEMBL428690 IC50 10.0 nM
O=C(NC1CCNCC1)c1n[nH]cc1NC(=O)c1c(Cl)cccc1Cl CHEMBL445813 IC50 10.0 nM
FC(F)(F)c1cnc(Nc2ccc(Br)cc2)nc1Nc1ccc2[nH]cnc2c1 CHEMBL364935 IC50 11.0 nM
Cc1ncc(-c2nc(Nc3ccc(C(=O)N4CC[C@H](N(C)C)C4)cc3)ncc2F)n1C(C)C CHEMBL460102 IC50 11.0 nM
Cc1ncc(-c2nc(Nc3ccc(C(=O)N4CC[C@@H](N(C)C)C4)cc3)ncc2F)n1C(C)C CHEMBL460103 IC50 11.0 nM
CC(C)COc1ccc2sc3c(c2c1)NC[C@@H](C)NC3=O CHEMBL563308 IC50 11.0 nM
CCS(=N)(=O)c1ccc(Nc2ncc(Br)c(N[C@@H](C)[C@H](C)O)n2)cc1 CHEMBL3648122 IC50 11.0 nM
COC[C@@H](Nc1nc(Nc2ccc(S(C)(=N)=O)cc2)ncc1Br)[C@@H](C)O CHEMBL3648118 IC50 11.0 nM
NS(=O)(=O)c1ccc(N/N=C2\C(=O)Nc3ccc4ncccc4c32)cc1 CHEMBL409892 IC50 12.0 nM
COC(=O)c1ccc2c(c1)/C(=C/Nc1ccc(S(N)(=O)=O)cc1)C(=O)N2 CHEMBL409731 IC50 12.0 nM
O=C(Cc1ccc(Cl)cc1)Nc1n[nH]c2ccc(N3CCCS3(=O)=O)cc12 CHEMBL402157 IC50 12.0 nM
Cc1ncc(-c2nc(Nc3ccc(C(=O)NC4CCN(C)CC4)c(F)c3)ncc2F)n1C(C)C CHEMBL509406 IC50 12.0 nM
COc1ccc2sc3c(c2c1)NC[C@@H](C)NC3=O CHEMBL99780 IC50 12.0 nM
NS(=O)(=O)c1cccc(Nc2nccc(-c3ccnc(NCCCO)c3)n2)c1 CHEMBL2158843 IC50 12.0 nM
CC(C)S(=O)(=O)c1ccc(Nc2ncc(C(F)(F)F)c(O[C@H](C)[C@@H](C)O)n2)cc1 CHEMBL3644024 IC50 12.0 nM
CC(C)NCc1cccc2[nH]c(-c3n[nH]c4ncc(-c5cncc6ccccc56)cc34)nc12 CHEMBL401064 IC50 13.0 nM
Cn1cc(Nc2ncc3cnn([C@@H]4CC[C@H]5CCC[C@H]54)c3n2)cc1C(N)=O CHEMBL2012403 IC50 13.0 nM
C[C@H](O)[C@@H](C)Oc1nc(Nc2ccc(S(C)(=N)=O)cc2)ncc1Br CHEMBL3648073 IC50 13.0 nM
CN(C)C/C=C/C(=O)Nc1cccc(C(=O)Nc2cccc(Nc3ncc(Cl)c(-c4c[nH]c5ccccc45)n3)c2)c1 CHEMBL4303287 IC50 13.9 nM
Brc1cnc(Nc2ccc3[nH]cnc3c2)nc1Nc1ccc2[nH]cnc2c1 CHEMBL372503 IC50 14.0 nM
COc1cc(F)c(F)cc1C(=O)c1cnc(NC2CCN(S(C)(=O)=O)CC2)nc1N CHEMBL215086 Ki 14.0 nM
COc1ccc(F)cc1C(=O)c1cnc(NC2CCN(S(C)(=O)=O)CC2)nc1N CHEMBL268507 Ki 14.0 nM
CN1CCN(c2ccc3[nH]c(-c4n[nH]c5ncc(-c6cncc7ccccc67)cc45)nc3c2)CC1 CHEMBL249304 IC50 14.0 nM
C[C@@H](Nc1nc(Nc2ccc(S(=N)(=O)C3CC3)cc2)ncc1Br)C(C)(C)O CHEMBL3648074 IC50 14.0 nM
CN=S(C)(=O)c1ccc(Nc2ncc(Br)c(N[C@H](C)[C@H](C)O)n2)cc1 CHEMBL3648083 IC50 14.0 nM
CN(C)CCNS(=O)(=O)c1ccc(Nc2nccc(-c3cnc4ccccn34)n2)cc1 CHEMBL72548 IC50 15.0 nM
NS(=O)(=O)c1ccc(N/C=C2\C(=O)Nc3ccc4ncccc4c32)cc1 CHEMBL445945 IC50 15.0 nM
CC(C)=Cc1cccc2c1/C(=N/Nc1ccc(S(N)(=O)=O)cc1)C(=O)N2 CHEMBL270544 IC50 15.0 nM
Cc1cccc(Nc2ncc(C(F)(F)F)c(Nc3ccc4[nH]cnc4c3)n2)c1 CHEMBL444874 IC50 15.0 nM
FC(F)(F)c1ccc(Nc2ncc(C(F)(F)F)c(Nc3ccc4[nH]cnc4c3)n2)cc1 CHEMBL363138 IC50 15.0 nM
CN(C)CCNS(=O)(=O)c1ccc(Nc2cccc(-c3cnc4ccccn34)c2)cc1 CHEMBL1241849 IC50 15.0 nM
Nc1nccc(-c2cc(N3C[C@H](O)[C@@H](O)C3)ccc2O)n1 CHEMBL1800449 IC50 15.0 nM
Cn1cc(Nc2ncc3cnn(C4CCCCCC4)c3n2)cc1C(N)=O CHEMBL2012399 IC50 15.0 nM
CCS(=N)(=O)c1ccc(Nc2ncc(Br)c(N[C@H](COC)[C@@H](C)O)n2)cc1 CHEMBL3648120 IC50 15.0 nM
CN=S(C)(=O)c1ccc(Nc2ncc(Br)c(N[C@H](C)[C@H](C)O)n2)cc1OC CHEMBL3648114 IC50 15.0 nM
Nc1ncnn2ccc(C(=O)Nc3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12 CHEMBL1990583 pKi 15.85 nM
Cn1c2ccccc2c2c3c(c4c5ccccc5n(CCC#N)c4c21)CNC3=O CHEMBL302449 pKi 15.85 nM
CC(C)CC(=O)c1ccc2c(c1)/C(=C/Nc1ccc(S(N)(=O)=O)cc1)C(=O)N2 CHEMBL429142 IC50 16.0 nM
Cn1cc(Nc2ncc3cnn([C@H]4CC[C@H]5CCC[C@H]54)c3n2)cc1C(N)=O CHEMBL2012398 IC50 16.0 nM
CCOC(=O)N=S(C)(=O)c1ccc(Nc2ncc(Br)c(N[C@H](C)[C@H](C)O)n2)cc1 CHEMBL3648085 IC50 16.0 nM
CCS(=N)(=O)c1ccc(Nc2ncc(Br)c(N[C@H](COC)[C@H](C)O)n2)cc1 CHEMBL3648094 IC50 16.0 nM
Cc1ncc(-c2ccnc(Nc3ccc(S(C)(=O)=O)cc3)n2)n1C(C)C CHEMBL488436 IC50 16.0 nM
NS(=O)(=O)c1ccc(N/C=C2\C(=O)Nc3ccc(-c4cnco4)cc32)cc1 CHEMBL270132 IC50 17.0 nM
OCCCNc1cc(-c2ccnc(Nc3cccc(Cl)c3)n2)ccn1 CHEMBL300389 IC50 17.0 nM
COc1cccc(F)c1C(=O)c1cnc(NC2CCN(S(C)(=O)=O)CC2)nc1N CHEMBL385733 Ki 17.0 nM
CC(O)C(C)Sc1nc(Nc2ccc(S(C)(=N)=O)cc2)ncc1Br CHEMBL3648102 IC50 17.0 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(C(=O)N4C[C@H]5CC[C@@H](C4)N5C)cn3)nc2n1C1CCCC1 CHEMBL3691683 IC50 17.5 nM
CC(CO)Sc1nc(Nc2ccc(S(C)(=N)=O)cc2)ncc1Br CHEMBL3648106 IC50 18.0 nM
O=C1Nc2ccc(-c3cnco3)cc2/C1=C/Nc1ccc2c(c1)CS(=O)(=O)C2 CHEMBL1234087 IC50 19.0 nM
CC(C)Cc1cccc2c1/C(=N/Nc1ccc(S(N)(=O)=O)cc1)C(=O)N2 CHEMBL411224 IC50 19.0 nM
CC(C)COC(=O)c1ccc2c(c1)/C(=C/Nc1ccc(S(N)(=O)=O)cc1)C(=O)N2 CHEMBL269883 IC50 19.0 nM
Cc1cc(N2CCCS2(=O)=O)c2oc(-c3ccc(O)c(Br)c3)c(O)c(=O)c2c1 CHEMBL392776 IC50 19.0 nM
Nc1nc(NC2CCCC2)cc(-c2cc(N3C[C@H](O)[C@@H](O)C3)ccc2O)n1 CHEMBL1800464 IC50 19.0 nM
O=C1N=C(NCc2cccs2)S/C1=C\c1ccc2ncccc2c1 CHEMBL393929 IC50 19.0 nM
Cn1cc(Nc2ncc3cnn(C4CCC5(CC4)CC5)c3n2)cc1C(N)=O CHEMBL2012400 IC50 19.0 nM
CC(Sc1nc(Nc2ccc(S(C)(=N)=O)cc2)ncc1Br)C(C)(C)O CHEMBL3648104 IC50 19.0 nM
CCn1c(C)c(-c2ccnc(Nc3cccc(OC)c3)n2)sc1=O CHEMBL1986263 pKi 19.95 nM
COc1cc(Nc2ncc([N+](=O)[O-])c(Nc3ccccc3C(N)=O)n2)cc(OC)c1OC CHEMBL1241473 pKi 19.95 nM
O=C1Nc2ccc3ncsc3c2C1=CNc1ccc(S(=O)(=O)Nc2ccccn2)cc1 CHEMBL1973540 pKi 19.95 nM
CC(C)[C@H](CO)Nc1nc(NCc2ccc3c(c2)OCO3)c2ncn(C(C)C)c2n1 CHEMBL3085239 IC50 20.0 nM
O=C1N=C(N[C@@H]2C[C@H]2c2ccccc2)S/C1=C\c1ccc2ncccc2c1 CHEMBL235345 Ki 20.0 nM
CCCCOc1c(C(=O)c2c(F)cc(F)cc2F)c[nH]c2nncc1-2 CHEMBL79049 IC50 20.0 nM
Cc1cc(-c2cc(N3C[C@H](O)[C@@H](O)C3)ccc2O)nc(N)n1 CHEMBL1800450 IC50 20.0 nM
Nc1nc(NC2CCCCC2)cc(-c2cc(N3C[C@H](O)[C@@H](O)C3)ccc2O)n1 CHEMBL1800465 IC50 20.0 nM
O=S1(=O)NCCCNc2nc(ncc2Br)Nc2cccc1c2 CHEMBL1235529 IC50 20.0 nM
OCCCNc1cc(-c2ncnc(Nc3cccc(Cl)c3)n2)ccn1 CHEMBL191336 IC50 21.0 nM
Cn1cc(Nc2ncc3cnn([C@@H]4C[C@H]5C[C@H]5C4)c3n2)cc1C(=O)N1CCC[C@H]1CN1CCOCC1 CHEMBL2012412 IC50 21.0 nM
CCOC(=O)N=S(C)(=O)c1ccc(Nc2ncc(Br)c(O[C@H](C)[C@H](C)O)n2)cc1 CHEMBL3648093 IC50 21.0 nM
Cc1nc2ccc(-c3ccnc4[nH]c(C5CCN(CC(=O)N(C)C)CC5)cc34)cc2n1C(C)C CHEMBL5181709 IC50 21.0 nM
FC(F)(F)c1cnc(Nc2cccc(Cl)c2)nc1Nc1ccc2[nH]cnc2c1 CHEMBL372672 IC50 22.0 nM
Nc1cc2cc(-c3cncc(OC[C@@H](N)Cc4c[nH]c5ccccc45)c3)ccc2cn1 CHEMBL210390 IC50 22.0 nM
O=C(Cc1ccc(Br)cc1)Nc1n[nH]c2ccc(N3CCCS3(=O)=O)cc12 CHEMBL402370 IC50 22.0 nM
COC[C@@H]1CCCN1C(=O)c1cc(Nc2ncc3cnn([C@@H]4C[C@H]5C[C@H]5C4)c3n2)cn1C CHEMBL2012411 IC50 22.0 nM
CCC(Sc1nc(Nc2ccc(S(C)(=N)=O)cc2)ncc1Br)C(C)O CHEMBL3648103 IC50 22.0 nM
COC(=N)c1nc2ccc3ncnc(Nc4ccc(Cl)cc4Cl)c3c2s1 CHEMBL2386747 IC50 22.8 nM
c1ccc2c(-c3cnc4[nH]nc(-c5nc6ccccc6[nH]5)c4c3)cncc2c1 CHEMBL391437 IC50 23.0 nM
Nc1nc(-c2cc(N3C[C@H](O)[C@@H](O)C3)ccc2O)cc(C2CCCC2)n1 CHEMBL1800455 IC50 23.0 nM
NC1CCC(Nc2nc(NCc3cc(Cl)ccc3O)c3ncn(C4CCCC4)c3n2)CC1 CHEMBL2402947 IC50 23.0 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(C(=O)N4C[C@H]5CC[C@@H](C4)N5)cn3)nc2n1C1CCCC1 CHEMBL3691684 IC50 23.0 nM
C[C@@H](O)[C@@H](C)Oc1nc(Nc2ccc(S(=O)(=O)C3CCCC3)cc2)ncc1C(F)(F)F CHEMBL3644022 IC50 23.0 nM
N#Cc1ccc2[nH]c3c(c2c1)CC(=O)Nc1ccccc1-3 CHEMBL299756 IC50 24.0 nM
c1ccc(Nc2ncc(-c3ccnc(OC4CCCCC4)n3)s2)nc1 CHEMBL424696 IC50 24.0 nM
Cn1cc(Nc2ncc3cnn(C4CCC(C)(C)CC4)c3n2)cc1C(N)=O CHEMBL2012401 IC50 24.0 nM
Cn1cc(Nc2ncc3cnn([C@@H]4C[C@H]5C[C@H]5C4)c3n2)cc1C(N)=O CHEMBL2012402 IC50 24.0 nM
CC(C)n1ncc2cnc(Nc3cc(C(N)=O)n(C)c3)nc21 CHEMBL2012308 IC50 24.0 nM
C[C@@H](O)[C@@H](C)Oc1nc(Nc2ccc(S(=O)(=O)C(F)F)cc2)ncc1C(F)(F)F CHEMBL3644021 IC50 24.0 nM
CCn1cnc2c(Nc3cccc(Cl)c3)nc(N[C@@H]3CCCC[C@@H]3N)nc21 CHEMBL367625 IC50 25.0 nM
CC(C)Oc1nc(Nc2ccc3[nH]cnc3c2)ncc1C(F)(F)F CHEMBL191893 IC50 25.0 nM
C[C@@H]1CNc2c(sc3ccc4nc(Cl)ccc4c23)C(=O)N1 CHEMBL556392 IC50 25.0 nM
COc1ccc2sc3c(c2c1)NC[C@@H](CO)NC3=O CHEMBL553397 IC50 25.0 nM
C[C@H](Nc1nc(Nc2ccc(S(=N)(=O)CCO)cc2)ncc1Br)C(C)(C)O CHEMBL3648108 IC50 25.0 nM
CN1CC[C@@H](c2c(O)cc(O)c3c(=O)cc(-c4ccc(C(F)(F)F)cc4Cl)oc23)[C@@H]1CO CHEMBL3905910 IC50 25.0 nM
N#CCOc1ccc(Nc2nc(Nc3cccc(S(N)(=O)=O)c3)ncc2Br)cc1 CHEMBL1987034 pKi 25.12 nM
Clc1cc(-c2c[nH]c3ncccc23)cc(NCc2ccccc2)n1 CHEMBL1969588 pKi 25.12 nM
C[C@@H]1CNc2c(sc3ccc(O)cc23)C(=O)N1 CHEMBL559487 IC50 26.0 nM
CCOC(=O)N=S(C)(=O)c1ccc(Nc2ncc(Br)c(N[C@H](C)C(C)(C)O)n2)cc1 CHEMBL3648084 IC50 27.0 nM
COC[C@H](Nc1nc(Nc2ccc(S(C)(=N)=O)cc2)ncc1Br)[C@H](C)O CHEMBL3648119 IC50 27.0 nM
CCn1cnc2c(Nc3cccc(C#N)c3)nc(N[C@H]3CC[C@H](O)CC3)nc21 CHEMBL172140 IC50 28.0 nM
CCn1cnc2c(Nc3cccc(C(F)(F)F)c3)nc(N[C@H]3CC[C@H](O)CC3)nc21 CHEMBL368215 IC50 28.0 nM
COc1ccccc1C(=O)c1cnc(NC2CCN(S(C)(=O)=O)CC2)nc1N CHEMBL216126 Ki 28.0 nM
CN(C)c1ccc(CC(=O)Nc2n[nH]c3ccc(N4CCCS4(=O)=O)cc23)cc1 CHEMBL257831 IC50 28.0 nM
O=C(Cc1ccc(O)cc1)Nc1n[nH]c2ccc(N3CCCS3(=O)=O)cc12 CHEMBL255718 IC50 28.0 nM
CN1CCN(C(=O)c2cc(Nc3ncc4cc(-c5cnco5)n(C5CCCC5)c4n3)cn2C)CC1 CHEMBL2029908 IC50 28.0 nM
NS(=O)(=O)c1ccc(NC=C2C(=O)Nc3ccc4ncsc4c32)cc1 CHEMBL1794055 IC50 29.0 nM
COCc1cccc2[nH]c(-c3n[nH]c4ncc(-c5cccnc5)cc34)nc12 CHEMBL400859 IC50 29.0 nM
NS(=O)(=O)c1ccc(N/C=C2\C(=O)Nc3ccc4ncsc4c32)cc1 CHEMBL271595 IC50 29.0 nM
Cc1ncc(-c2ccnc(Nc3ccc(C(=O)NCCN(C)C)c(F)c3)n2)n1C(C)C CHEMBL453629 IC50 29.0 nM
CC(C)n1cnc2c(Nc3cccc(Cl)c3)nc(NC3CCC(N)CC3)nc21 CHEMBL102871 IC50 30.0 nM
CCn1cnc2c(Nc3cccc(Cl)c3)nc(N[C@H]3CC[C@H](O)CC3)nc21 CHEMBL177138 IC50 30.0 nM
CCn1cnc2c(Nc3cccc(Cl)c3)nc(N[C@H]3CC[C@@H](O)CC3)nc21 CHEMBL177057 IC50 30.0 nM
O=C(Cc1cccc(F)c1)Nc1n[nH]c2ccc(N3CCCS3(=O)=O)cc12 CHEMBL255262 IC50 30.0 nM
O=C1NC(=O)c2c1c(-c1ccccc1Cl)cc1c2c2cc(O)c(OCCCN3CCCC3)cc2n1CCO CHEMBL270021 IC50 30.0 nM
Cn1c2cc(OCCCN3CCCC3)c(O)cc2c2c3c(c(-c4ccccc4Cl)cc21)C(=O)NC3=O CHEMBL255427 IC50 30.0 nM
CN1CC[C@@H](c2c(O)cc(O)c3c(=O)cc(-c4ccccc4Cl)oc23)[C@@H](O)C1 CHEMBL8817 IC50 30.0 nM
CCn1cnc2c(Nc3ccc(F)cc3)nc(N[C@H]3CC[C@H](N)CC3)nc21 CHEMBL171891 IC50 31.0 nM
O=C1Nc2ccc3ncsc3c2/C1=C/Nc1ccc2c(c1)CS(=O)(=O)C2 CHEMBL391229 IC50 31.0 nM
CCc1cc(-c2cc(N3C[C@H](O)[C@@H](O)C3)ccc2O)nc(N)n1 CHEMBL1800451 IC50 31.0 nM
Nc1nc(-c2cc(N3C[C@H](O)[C@@H](O)C3)ccc2O)cc(C2CCCCCC2)n1 CHEMBL1800457 IC50 31.0 nM
Nc1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3I)cc12 CHEMBL1975128 pKi 31.62 nM
Cc1n[nH]c2cnc(-c3cncc(OCC(N)Cc4cccc(C(F)(F)F)c4)c3)cc12 CHEMBL1998159 pKi 31.62 nM
CN1CCC(c2c(O)cc(O)c3c(=O)cc(-c4ccccc4Cl)oc23)C(O)C1 CHEMBL422897 pKi 31.62 nM
Cc1cccc(NC(=O)Nc2ccc(NC(=O)c3csc4ncnc(N)c34)cc2)c1 CHEMBL1965507 pKi 31.62 nM
NCCCn1cc(-c2cc(-c3cc4ccccc4s3)c3[nH]ncc3c2)c2nc(N)ncc21 CHEMBL592030 pKi 31.62 nM
Clc1cc(-c2c[nH]c3ncccc23)nc(NC2CCCCC2)n1 CHEMBL2006439 pKi 31.62 nM
O=C1Cc2c([nH]c3ccc([N+](=O)[O-])cc23)-c2ccccc2N1 CHEMBL50894 pKi 31.62 nM
CCn1cnc2c(Nc3cccc(F)c3)nc(N[C@H]3CC[C@H](O)CC3)nc21 CHEMBL174773 IC50 32.0 nM
Fc1ccc(Oc2nc(Nc3ccc4[nH]cnc4c3)ncc2C(F)(F)F)cc1 CHEMBL370316 IC50 32.0 nM
Cc1cc(N2CCCS2(=O)=O)c2oc(-c3ccc(O)c(Cl)c3)c(O)c(=O)c2c1 CHEMBL392775 IC50 33.0 nM
Brc1cnc(Nc2ccc3[nH]cnc3c2)nc1Nc1ccc(Oc2cccnc2)cc1 CHEMBL194032 IC50 34.0 nM
Brc1cnc(Nc2ccc3[nH]cnc3c2)nc1NC1CCc2ccccc21 CHEMBL370485 IC50 34.0 nM
O=C(Cc1cccc(Cl)c1)Nc1n[nH]c2ccc(N3CCCS3(=O)=O)cc12 CHEMBL404504 IC50 34.0 nM
Clc1cccc(Nc2nccc(-c3ccnc(N4CCOCC4)c3)n2)c1 CHEMBL2158844 IC50 35.0 nM
CCN1CCN(Cc2cnc(Nc3cc(-c4cc(F)c5nc(C)n(C(C)C)c5c4)ccn3)cn2)CC1 CHEMBL4204030 IC50 35.8 nM
NS(=O)(=O)c1cccc(Nc2nccc(-c3ccnc(N4CCCCC4)c3)n2)c1 CHEMBL2158857 IC50 36.0 nM
C[C@@H](Oc1nc(Nc2ccc(S(=O)(=O)C3CC3)cc2)ncc1C(F)(F)F)C(C)(C)O CHEMBL3644019 IC50 36.0 nM
COc1ccc(Cc2nnc(N3CCN(C(=O)Nc4ccc(Cl)c(C(F)(F)F)c4)CC3)c3ccccc23)cc1 CHEMBL5409788 IC50 36.8 nM
CC(C)c1cccc2c1/C(=N/Nc1ccc(S(N)(=O)=O)cc1)C(=O)N2 CHEMBL411426 IC50 37.0 nM
O=C1Nc2ccc3ncsc3c2/C1=C/Nc1ccc(S(=O)(=O)NCCc2c[nH]cn2)cc1 CHEMBL1964251 IC50 38.0 nM
CS(=O)(=O)N1CCC(Nc2ncc(C(=O)c3c(F)cccc3F)c(N)n2)CC1 CHEMBL265903 Ki 38.0 nM
Cn1cc(Nc2ncc3cnn(C4C5CC6CC(C5)CC4C6)c3n2)cc1C(N)=O CHEMBL2012397 IC50 38.0 nM
CCn1cnc2c(Nc3cccc(Cl)c3)nc(N[C@H]3CC[C@H](N)CC3)nc21 CHEMBL367691 IC50 39.0 nM
CCn1cnc2c(Nc3cccc(Cl)c3)nc(N[C@H]3CC[C@@H](N)CC3)nc21 CHEMBL173459 IC50 39.0 nM
CCn1cnc2c(Nc3cccc(Cl)c3)nc(N3CCCCC3CO)nc21 CHEMBL176559 IC50 39.0 nM
CS(=O)(=O)c1ccc(N/C=C2\C(=O)Nc3ccc4ncsc4c32)cc1 CHEMBL1964260 IC50 39.0 nM
CC(C)NC(=O)c1cccc2[nH]c(-c3n[nH]c4ncc(-c5cncc6ccccc56)cc34)nc12 CHEMBL249502 IC50 39.0 nM
Cn1cc(/C=C2\Oc3cccc(O)c3C2=O)c2c(-c3ccc(C(=O)NCCO)cc3)ccnc21 CHEMBL1092754 IC50 39.2 nM
OC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1986943 pKi 39.81 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4cccc(Cl)c4)c3)cc12 CHEMBL1974870 pKi 39.81 nM
CCCC(=O)Nc1n[nH]c2ccc(-c3cccc(F)c3F)cc12 CHEMBL1985406 pKi 39.81 nM
CC(=O)NCC(=O)N1C2CCC1c1cc(Nc3ncc(C(F)(F)F)c(NC4CCC4)n3)ccc12 CHEMBL1983111 pKi 39.81 nM
COc1ccc(C(=O)Nc2n[nH]c3ccc(-c4cn(Cc5ccccc5)nn4)cc23)cc1OC CHEMBL1991078 pKi 39.81 nM
NC(=O)c1ccc(-c2c[nH]c3nccc(Cl)c23)cc1 CHEMBL1982711 pKi 39.81 nM
c1ccc(Cn2nnc(-c3ccc4[nH]ncc4c3)c2C2CC2)cc1 CHEMBL1975418 pKi 39.81 nM
CNS(=O)(=O)c1ccccc1Nc1nc(Nc2cc(N3CCN(C(C)=O)CC3)ccc2OC)ncc1Br CHEMBL1971029 pKi 39.81 nM
O[C@H]1CC[C@H](Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL2062936 pKi 39.81 nM
CCn1cnc2c(Nc3ccc(F)cc3)nc(N[C@H]3CC[C@H](O)CC3)nc21 CHEMBL174977 IC50 40.0 nM
O=C(Cc1ccc2ccccc2c1)Nc1n[nH]c2ccc(N3CCCS3(=O)=O)cc12 CHEMBL254979 IC50 40.0 nM
CSc1ccc(CC(=O)Nc2n[nH]c3ccc(N4CCCS4(=O)=O)cc23)cc1 CHEMBL415789 IC50 40.0 nM
Cc1ccc(CC(=O)Nc2n[nH]c3ccc(N4CCCS4(=O)=O)cc23)cc1 CHEMBL256558 IC50 40.0 nM
O=C1C(c2c(O)[nH]c3ccc(S(=O)(=O)O)cc23)=Nc2ccccc21 CHEMBL1207227 IC50 40.0 nM
C[C@@H]1CCCN1C(=O)c1cc(Nc2ncc3cnn([C@@H]4C[C@H]5C[C@H]5C4)c3n2)cn1C CHEMBL2012406 IC50 40.0 nM
COc1ccc2c(c1)/C(=C/c1cnc[nH]1)C(=O)N2 CHEMBL258805 IC50 40.0 nM
COCCNS(=O)(=O)c1ccc(Nc2ncc(-c3cnc4cccnn34)cn2)cc1 CHEMBL4584344 IC50 40.0 nM
CCn1cnc2c(Nc3cccc(Cl)c3)nc(N3CCC[C@@H]3CN)nc21 CHEMBL368351 IC50 41.0 nM
O=C1Nc2ccc3ncsc3c2/C1=C/Nc1ccc(S(=O)(=O)Nc2ccccc2)cc1 CHEMBL1964244 IC50 41.0 nM
O=C1Nc2ccc3ncsc3c2/C1=C/Nc1ccc(S(=O)(=O)NCCO)cc1 CHEMBL1964246 IC50 41.0 nM
CC(C)Oc1cccc2c1/C(=N/Nc1ccc(S(N)(=O)=O)cc1)C(=O)N2 CHEMBL271160 IC50 41.0 nM
OCc1cccc2[nH]c(-c3n[nH]c4ncc(-c5cncc6ccccc56)cc34)nc12 CHEMBL248890 IC50 41.0 nM
Cn1cc(Nc2ncc3cnn([C@@H]4C[C@H]5C[C@H]5C4)c3n2)cc1C(=O)N1CCCC1 CHEMBL2012407 IC50 41.0 nM
C(=C/c1n[nH]c2cc(-c3ccnc4[nH]ccc34)ccc12)\c1ccccc1 CHEMBL3953845 Ki 41.0 nM
C[C@@H](O)[C@@H](C)Oc1nc(Nc2ccc(S(=O)(=O)c3ccccc3)cc2)ncc1C(F)(F)F CHEMBL3644020 IC50 41.0 nM
CC(C)c1cnn2c(NCc3ccccc3)cc(NC[C@]3(CO)CCNC3)nc12 CHEMBL4553241 IC50 41.0 nM
O=C1Nc2ccc3ncsc3c2/C1=C/Nc1ccc(S(=O)(=O)N[n+]2ccc3ccccc3c2)cc1 CHEMBL2112297 IC50 42.0 nM
O=C(Cc1ccc(-c2ccccc2)cc1)Nc1n[nH]c2ccc(N3CCCS3(=O)=O)cc12 CHEMBL402759 IC50 42.0 nM
COc1ccc(Cc2nnc(N3CCN(C(=S)Nc4cccc(Cl)c4)CC3)c3ccccc23)cc1 CHEMBL5411187 IC50 42.19 nM
NS(=O)(=O)c1ccc(N/N=C2\C(=O)Nc3ccc4ncsc4c32)cc1 CHEMBL407709 IC50 43.0 nM
FC(F)(F)c1cnc(Nc2ccc3[nH]cnc3c2)nc1OC1CCCCC1 CHEMBL193860 IC50 43.0 nM
CCS(=O)(=O)N1CCC(Nc2ncc(C(=O)c3ccccc3OC)c(N)n2)CC1 CHEMBL385190 Ki 43.0 nM
CCOC(=O)N=S(=O)(CC)c1ccc(Nc2ncc(Br)c(N[C@H](C)[C@H](C)O)n2)cc1 CHEMBL3648089 IC50 43.0 nM
C=CCS(=O)(=O)c1ccc(Nc2ncc(C(F)(F)F)c(O[C@H](C)C(C)(C)O)n2)cc1 CHEMBL3644023 IC50 43.0 nM
CCS(=N)(=O)c1ccc(Nc2ncc(Br)c(N[C@@H](COC)[C@H](C)O)n2)cc1 CHEMBL3648121 IC50 44.0 nM
C[C@@H](Nc1nc(Nc2ccc(S(=N)(=O)C3CCCC3)cc2)ncc1Br)C(C)(C)O CHEMBL3648078 IC50 44.0 nM
CCN1CCN(Cc2cnc(Nc3cc(-c4cc(F)c5nc(C)n(C(C)C)c5c4)c(F)cn3)cn2)CC1 CHEMBL4218267 IC50 44.0 nM
S=C(Nc1cccc(Cl)c1)N1CCN(c2nnc(Cc3ccccc3)c3ccccc23)CC1 CHEMBL5426122 IC50 44.52 nM
COCCOCCOCCOCCN(C)S(=O)(=O)c1ccc(N/C=C2\C(=O)Nc3ccc4ncsc4c32)cc1 CHEMBL1964249 IC50 45.0 nM
N=C(N)NS(=O)(=O)c1ccc(N/C=C2\C(=O)Nc3ccc4ncsc4c32)cc1 CHEMBL1964255 IC50 45.0 nM
Nc1nc(-c2cc(N3C[C@H](O)[C@@H](O)C3)ccc2O)cc(C2CCCCC2)n1 CHEMBL1800456 IC50 45.0 nM
CCc1cccc2c1/C(=N/Nc1ccc(S(N)(=O)=O)cc1)C(=O)N2 CHEMBL411425 IC50 46.0 nM
NC1CCC(Nc2nc(NCc3ccc(-c4ccccc4O)nc3)c3ncn(C4CCCC4)c3n2)CC1 CHEMBL2402946 IC50 46.8 nM
O=C(Cc1cccc(Br)c1)Nc1n[nH]c2ccc(N3CCCS3(=O)=O)cc12 CHEMBL402158 IC50 47.0 nM
Cn1cc(Nc2ncc3cnn([C@@H]4C[C@H]5C[C@H]5C4)c3n2)cc1C(=O)N1CCC[C@H]1CN1CCCC1 CHEMBL2012410 IC50 47.0 nM
CN(C)CCc1ccc(Nc2ncc(Cl)c(-c3c[nH]c4ccccc34)n2)cc1 CHEMBL234452 IC50 48.0 nM
NS(=O)(=O)c1cccc(Nc2nccc(-c3ccnc(N4CC5CCC(C4)O5)c3)n2)c1 CHEMBL2158855 IC50 48.0 nM
NC1CCC(Nc2nc(NCc3ccc(-c4cccs4)nc3)c3ncn(C4CCCC4)c3n2)CC1 CHEMBL2403096 IC50 49.0 nM
CCOC(=O)N=S(=O)(CC)c1ccc(Nc2ncc(Br)c(O[C@H](C)[C@H](C)O)n2)cc1 CHEMBL3648092 IC50 49.0 nM
CCC(CO)Sc1nc(Nc2ccc(S(C)(=N)=O)cc2)ncc1Br CHEMBL3648127 IC50 49.0 nM
COc1ccc(Cc2nnc(N3CCN(C(=S)Nc4ccc(Cl)cc4)CC3)c3ccccc23)cc1 CHEMBL5436647 IC50 49.5 nM
CC(C)[C@H](CO)Nc1nc(Nc2cccc(Cl)c2)c2ncn(C(C)C)c2n1 CHEMBL23327 IC50 50.0 nM
CN(C)S(=O)(=O)c1ccc(N/C=C2\C(=O)Nc3ccc4ncsc4c32)cc1 CHEMBL1964247 IC50 50.0 nM
Cc1cccc(CC(=O)Nc2n[nH]c3ccc(N4CCCS4(=O)=O)cc23)c1 CHEMBL403605 IC50 50.0 nM
O=C(Cc1ccc(F)cc1)Nc1n[nH]c2ccc(N3CCCS3(=O)=O)cc12 CHEMBL255263 IC50 50.0 nM
Cc1ncc(-c2nc(Nc3ccc(C(=O)NC4CCN(C)CC4)cc3)ncc2F)n1C(C)C CHEMBL507722 IC50 50.0 nM
Cn1cc(Nc2ncc3cnn(C4CCC5(CC5)C4)c3n2)cc1C(N)=O CHEMBL2012309 IC50 50.0 nM
NC1CCC(Nc2nc(NCc3ccc(-c4ccco4)nc3)c3ncn(C4CCCC4)c3n2)CC1 CHEMBL2403094 IC50 50.0 nM
C[C@H](CO)Nc1nc(Nc2ccc(S(N)(=O)=O)cc2)ncc1Br CHEMBL4741442 IC50 50.0 nM
C[C@H](CO)Nc1nc(Nc2ccc(S(N)(=O)=O)cc2)ncc1Br CHEMBL4764656 IC50 50.0 nM
NS(=O)(=O)c1cccc(Nc2ncc3ccn(-c4ccccc4)c3n2)c1 CHEMBL1988163 pKi 50.12 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4c[nH]c5ccccc45)c3)cc12 CHEMBL1970903 pKi 50.12 nM
Nc1ncnc2scc(C(=O)Nc3ccc(NC(=O)Nc4ccccc4)cc3)c12 CHEMBL1988594 pKi 50.12 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4ccc(Cl)c(Cl)c4)c3)cc12 CHEMBL1991063 pKi 50.12 nM
NS(=O)(=O)c1ccc(N/N=C2\C(=O)Nc3ccc(C(=O)NCc4cccnc4)cc32)cc1 CHEMBL271953 IC50 51.0 nM
COC[C@@H](C)Oc1nc(Nc2ccc(S(C)(=O)=O)cc2)ncc1C(F)(F)F CHEMBL3644027 IC50 51.0 nM
COc1ccc(Cc2nnc(N3CCN(C(=O)Nc4ccc(OC)cc4)CC3)c3ccccc23)cc1 CHEMBL5440832 IC50 51.97 nM
O=C1Nc2ccc3ncsc3c2/C1=C/Nc1ccc(S(=O)(=O)NCc2ccccc2)cc1 CHEMBL1964242 IC50 52.0 nM
C[C@@H]1CNc2c(sc3ccc(OCC4CC4)cc23)C(=O)N1 CHEMBL563672 IC50 52.0 nM
N[C@H]1CC[C@H](Nc2nc(NCc3ccccc3)c3ncn(C4CCCC4)c3n2)CC1 CHEMBL150261 IC50 52.0 nM
O=C(Nc1c[nH]nc1-c1nc2ccccc2[nH]1)c1ccccc1 CHEMBL522891 IC50 52.0 nM
CN1CCN(Cc2ccc(NC(=O)Nc3ccc(Oc4ccnc(N)n4)cc3)cc2C(F)(F)F)CC1 CHEMBL4472486 Kd 52.7 nM
CCN(CC)C(=O)c1cccc2[nH]c(-c3n[nH]c4ncc(-c5cncc6ccccc56)cc34)nc12 CHEMBL251739 IC50 53.0 nM
CC(C)c1cnn2c(NCc3ccccc3-n3cccn3)nc(OC3CCCNC3)nc12 CHEMBL4562323 IC50 53.0 nM
O=C(Nc1ccccc1)N1CCN(c2nnc(Cc3ccccc3)c3ccccc23)CC1 CHEMBL5398705 IC50 53.77 nM
O=C(Nc1cc(C2CCC2)c[nH]1)Nc1cccc2ccncc12 CHEMBL1241758 IC50 55.0 nM
NS(=O)(=O)c1cccc(Nc2nccc(-c3ccnc(N4CCOCC4)c3)n2)c1 CHEMBL2158845 IC50 55.0 nM
CC(C)(O)CSc1nc(Nc2ccc(S(C)(=N)=O)cc2)ncc1Br CHEMBL3648128 IC50 55.0 nM
CNS(=O)(=O)Cc1ccc(N/N=C2\C(=O)Nc3ccc4ncsc4c32)cc1 CHEMBL1234086 IC50 56.0 nM
O=C(O)c1ccc2c(c1)nc(Nc1cccc(Cl)c1)c1ccncc12 CHEMBL1230165 IC50 56.0 nM
NC1CCC(Nc2nc(NCc3ccc(-n4cccn4)cc3)c3ncn(C4CCCC4)c3n2)CC1 CHEMBL2403088 IC50 58.0 nM
O=C(Nc1ccc(Cl)cc1)N1CCN(c2nnc(Cc3ccccc3)c3ccccc23)CC1 CHEMBL5431565 IC50 58.4 nM
CCC(C)(O)C#Cc1nc(Nc2cccc(Cl)c2)c2ncn(C(C)C)c2n1 CHEMBL282193 IC50 60.0 nM
CCC(C)(O)C#Cc1nc(NCc2ccc(Cl)cc2)c2ncn(C(C)C)c2n1 CHEMBL24484 IC50 60.0 nM
CN1CCC(c2c(O)cc(O)c3c2O/C(=C\c2ccc([N+](=O)[O-])cc2)C3=O)CC1 CHEMBL45477 IC50 60.0 nM
CC(C)(CO)CNC(=O)c1ccc2c(c1)/C(=N/Nc1ccc(S(N)(=O)=O)cc1)C(=O)N2 CHEMBL410072 IC50 60.0 nM
OCCCNc1cncc(-c2ncnc(Nc3cccc(Cl)c3)n2)c1 CHEMBL365937 IC50 60.0 nM
O=C(Cc1ccc(-c2ccncc2)cc1)Nc1n[nH]c2ccc(N3CCCS3(=O)=O)cc12 CHEMBL254171 IC50 60.0 nM
CCN(CC)c1ccc(CC(=O)Nc2n[nH]c3ccc(N4CCCS4(=O)=O)cc23)cc1 CHEMBL258039 IC50 60.0 nM
Nc1ccc(CC(=O)Nc2n[nH]c3ccc(N4CCCS4(=O)=O)cc23)cc1 CHEMBL255932 IC50 60.0 nM
NS(=O)(=O)c1ccc(N/N=C2\C(=O)Nc3ccc(C(=O)NCCc4c[nH]cn4)cc32)cc1 CHEMBL272028 IC50 60.0 nM
CNC(=O)Nc1ccc(-c2cc(-c3ccnc(Nc4cccc(S(N)(=O)=O)c4)n3)ccn2)cc1 CHEMBL2158858 IC50 62.0 nM
O=C(c1ccccc1)N1CCN(c2nnc(Cc3ccccc3)c3ccccc23)CC1 CHEMBL5424761 IC50 62.46 nM
Cc1cc(N2CCCS2(=O)=O)c2oc(-c3ccc(O)c(C(F)(F)F)c3)c(O)c(=O)c2c1 CHEMBL233153 IC50 63.0 nM
CCOC(=O)N=S(C)(=O)c1ccc(Nc2ncc(Br)c(N[C@H](C)C(C)(C)O)n2)cc1C CHEMBL3648090 IC50 63.0 nM
NC(=O)c1cc(-c2ccnc(N)n2)[nH]c1-c1ccc(Cl)cc1Cl CHEMBL1965660 pKi 63.1 nM
NC(=O)c1cccc(-c2cnc3[nH]cc(-c4ccccc4)c3c2)c1 CHEMBL1982957 pKi 63.1 nM
CN(c1ncccc1CNc1nc(Nc2ccc3c(c2)CC(=O)N3)ncc1C(F)(F)F)S(C)(=O)=O CHEMBL1084546 pKi 63.1 nM
O=C(Nc1cnccn1)Nc1ccnc2ccc(C(F)(F)F)cc12 CHEMBL1976455 pKi 63.1 nM
CNS(=O)(=O)c1ccc(N/C=C2\C(=O)Nc3ccc4ncsc4c32)cc1 CHEMBL1964245 IC50 64.0 nM
CN(c1ccccn1)S(=O)(=O)c1ccc(N/C=C2\C(=O)Nc3ccc4ncsc4c32)cc1 CHEMBL1964253 IC50 64.0 nM
COc1cccc(COc2ccc3sc4c(c3c2)NC[C@@H](C)NC4=O)c1 CHEMBL541448 IC50 64.0 nM
NC1CCC(Nc2nc(NCc3ccc(-c4ccoc4)nc3)c3ncn(C4CCCC4)c3n2)CC1 CHEMBL2403095 IC50 66.0 nM
CC(=O)N1CCC(n2cc(Nc3ncc(Cl)c(-c4cnc5ccccn45)n3)cn2)CC1 CHEMBL3823659 IC50 66.0 nM
C(=C/c1n[nH]c2cc(-c3ccncc3)ccc12)\c1ccc2c(c1)OCO2 CHEMBL3930293 Ki 66.0 nM
COc1ccc(NC(=O)N2CCN(c3nnc(Cc4ccccc4)c4ccccc34)CC2)cc1 CHEMBL5438882 IC50 66.47 nM
O=C(Cc1cccc2ccccc12)Nc1n[nH]c2ccc(N3CCCS3(=O)=O)cc12 CHEMBL254367 IC50 67.0 nM
CCS(=N)(=O)c1ccc(Nc2ncc(Br)c(N[C@@H](C)C(C)(C)O)n2)cc1 CHEMBL3648124 IC50 68.0 nM
NC(=O)c1ccc(Nc2nc(N)c(N=O)c(OCC3CCCCC3)n2)cc1 CHEMBL101801 IC50 70.0 nM
S=C(Nc1ccccc1)N1CCN(c2nnc(Cc3ccccc3)c3ccccc23)CC1 CHEMBL5407116 IC50 70.0 nM
Cc1ncc(-c2ccnc(Nc3ccc(C(=O)N4CCN(C)CC4)cc3)n2)n1C(C)C CHEMBL455467 IC50 71.0 nM
COCCOCCOCCOCCNS(=O)(=O)c1ccc(N/C=C2\C(=O)Nc3ccc4ncsc4c32)cc1 CHEMBL1964250 IC50 72.0 nM
CC(O)CSc1nc(Nc2ccc(S(C)(=N)=O)cc2)ncc1Br CHEMBL3648101 IC50 72.0 nM
NS(=O)(=O)c1ccc(N/N=C2\C(=O)Nc3ccc(C(=O)NCc4ccncc4)cc32)cc1 CHEMBL272165 IC50 74.0 nM
O=C(Nc1ccccn1)Nc1cccc2c1C1CCCCN1C2=O CHEMBL2180862 IC50 75.0 nM
CCOC(=O)N=S(C)(=O)c1ccc(Nc2ncc(Br)c(N[C@H](C)[C@H](C)O)n2)cc1C CHEMBL3648091 IC50 75.0 nM
NS(=O)(=O)c1ccc(N/N=C2\C(=O)Nc3ccc(O)cc32)cc1 CHEMBL409690 IC50 77.0 nM
CCOc1nc(Nc2ccc3[nH]cnc3c2)ncc1C(F)(F)F CHEMBL194495 IC50 77.0 nM
NC1CCC(Nc2nc(NCc3ccc(-c4cccc(F)c4)nc3)c3ncn(C4CCCC4)c3n2)CC1 CHEMBL2403093 IC50 77.0 nM
C=S(N)(=O)c1ccc(Nc2ncc(Br)c(N[C@H](C)CO)n2)cc1 CHEMBL3648099 IC50 79.0 nM
CN1CC[C@@H](c2c(O)cc(O)c3c(=O)cc(-c4ccccc4Cl)oc23)[C@@H]1CO CHEMBL3991935 IC50 79.0 nM
O=C(O)c1ccccc1Nc1ccnc(Nc2ccc3cn[nH]c3c2)n1 CHEMBL244378 pKi 79.43 nM
COc1cc(-c2ccc3c(c2)Nc2ccc(C(=O)NCc4cccc(F)c4)cc2NC3=O)ccc1O CHEMBL2000832 pKi 79.43 nM
O=C(Nc1cnccn1)Nc1ccnc2ccccc12 CHEMBL1981720 pKi 79.43 nM
O=C(O)c1ccccc1Nc1ccnc(Nc2ccc3[nH]ncc3c2)n1 CHEMBL396523 pKi 79.43 nM
Cc1cc(C)cc(NC(=O)Nc2ccc(NC(=O)c3csc4ncnc(N)c34)cc2)c1 CHEMBL1970203 pKi 79.43 nM
CCn1cnc2c(Nc3cccc(Cl)c3)nc(N3CCC[C@@H]3CO)nc21 CHEMBL366734 IC50 80.0 nM
CCn1cnc2c(Nc3cccc(Cl)c3)nc(NCCN)nc21 CHEMBL173647 IC50 80.0 nM
O=C(Cc1ccccc1)Nc1n[nH]c2ccc(N3CCCS3(=O)=O)cc12 CHEMBL255255 IC50 80.0 nM
O=C(Cc1ccccc1Cl)Nc1n[nH]c2ccc(N3CCCS3(=O)=O)cc12 CHEMBL255463 IC50 80.0 nM
Cc1nc(N)sc1-c1ccnc(Nc2cccc([N+](=O)[O-])c2)n1 CHEMBL298445 Ki 80.0 nM
CCc1cnc(CSc2cnc(NC(=O)Cc3cccnc3)s2)o1 CHEMBL129396 IC50 80.0 nM
COCCOc1ccc2sc3c(c2c1)NC[C@@H](C)NC3=O CHEMBL559411 IC50 81.0 nM
CC[C@H](CO)Nc1nc(NCc2ccccc2)c2ncn(C(C)C)c2n1 CHEMBL14762 IC50 81.7 nM
C#CCS(=O)(=O)c1ccc(Nc2ncc(C(F)(F)F)c(O[C@H](C)C(C)(C)O)n2)cc1 CHEMBL3644025 IC50 82.0 nM
NS(=O)(=O)c1ccc(N/N=C2\C(=O)Nc3ccc4[nH]nc(Cl)c4c32)cc1 CHEMBL269882 IC50 83.0 nM
COc1ccc(C(=O)N2CCN(c3nnc(Cc4ccccc4)c4ccccc34)CC2)cc1 CHEMBL5417371 IC50 83.06 nM
COc1ccc(Cc2nnc(N3CCN(C(=O)Nc4ccccc4)CC3)c3ccccc23)cc1 CHEMBL5417190 IC50 83.23 nM
COc1ccc(Cc2nnc(N3CCN(C(=S)Nc4ccc(OC)cc4)CC3)c3ccccc23)cc1 CHEMBL5431456 IC50 84.39 nM
CCn1cnc2c(Nc3cccc(C#N)c3)nc(N[C@H]3CC[C@H](N)CC3)nc21 CHEMBL435330 IC50 85.0 nM
COc1ccc(Cc2nnc(N3CCN(C(=S)Nc4ccccc4)CC3)c3ccccc23)cc1 CHEMBL5396190 IC50 85.05 nM
Cc1c([N+](=O)[O-])ccc2c1/C(=N/Nc1ccc(S(N)(=O)=O)cc1)C(=O)N2 CHEMBL272667 IC50 87.0 nM
COc1cccc(NC(=S)N2CCN(c3nnc(Cc4ccccc4)c4ccccc34)CC2)c1 CHEMBL5436482 IC50 88.4 nM
CCn1cnc2c(Nc3cccc(OC)c3)nc(N[C@H]3CC[C@H](O)CC3)nc21 CHEMBL368202 IC50 90.0 nM
CC[C@H](CO)Nc1nc(NCc2ccc(-c3ccccn3)cc2)c2ncn(C3CCCC3)c2n1 CHEMBL2402949 IC50 90.0 nM
CCC(Sc1nc(Nc2ccc(S(C)(=N)=O)cc2)ncc1Br)C(C)(C)O CHEMBL3648105 IC50 91.0 nM
Nc1ccccc1CNc1nc(NC2CCC(N)CC2)nc2c1ncn2C1CCCC1 CHEMBL2402948 IC50 93.0 nM
CC(C)c1cc(-c2cc(N3C[C@H](O)[C@@H](O)C3)ccc2O)nc(N)n1 CHEMBL1800452 IC50 94.0 nM
COc1cc(F)ccc1-c1ccnc(NC(=O)[C@H]2CCC[C@@H](NC(C)=O)C2)c1 CHEMBL3673434 IC50 94.0 nM
COc1cc(F)ccc1-c1cc(NC(=O)[C@H]2CCC[C@@H](NC(C)=O)C2)ncc1Cl CHEMBL4755256 IC50 94.0 nM
NS(=O)(=O)c1ccc(N/N=C2\C(=O)Nc3ccc(I)cc32)cc1 CHEMBL273060 IC50 95.0 nM
CCOC(=O)N=S(=O)(CC)c1ccc(Nc2ncc(Br)c(N[C@H](C)C(C)(C)O)n2)cc1 CHEMBL3648088 IC50 96.0 nM
Cc1cccc2[nH]c(-c3n[nH]c4ncc(-c5cncc6ccccc56)cc34)nc12 CHEMBL400858 IC50 97.0 nM
CCC(C)Sc1nc(Nc2ccc(S(C)(=N)=O)cc2)ncc1Br CHEMBL3648100 IC50 97.0 nM
Cc1nc2c(F)cc(-c3cc(Nc4cnc(CN5CCN(C(C)C)CC5)cn4)ncn3)cc2n1C(C)C CHEMBL4202432 IC50 97.2 nM
CC(C)OCc1cccc2[nH]c(-c3n[nH]c4ncc(-c5cncc6ccccc56)cc34)nc12 CHEMBL249094 IC50 99.0 nM
CC(C)C(CO)Nc1nc(NCc2cccc(O)c2)c2ncn(C(C)C)c2n1 CHEMBL84944 IC50 100.0 nM
CN1CCC(c2c(O)cc(O)c3c(=O)cc(-c4ccccc4Cl)oc23)[C@@H](O)C1 CHEMBL418203 IC50 100.0 nM
CCn1cnc2c(Nc3ccc(F)cc3)nc(N[C@H]3CC[C@@H](N)CC3)nc21 CHEMBL173619 IC50 100.0 nM
O=C1Nc2ccc3ncsc3c2/C1=C/Nc1ccc(S(=O)(=O)Nc2ccccn2)cc1 CHEMBL1276446 IC50 100.0 nM
NS(=O)(=O)Cc1ccc(N/C=C2\C(=O)Nc3ccc4ncsc4c32)cc1 CHEMBL1964257 IC50 100.0 nM
N[C@H](COc1cncc(-c2ccc3cnccc3c2)c1)Cc1c[nH]c2ccccc12 CHEMBL383264 IC50 100.0 nM
CC(C)n1cnc2c(NCc3ccccc3O)nc(NCCCO)nc21 CHEMBL419931 IC50 100.0 nM
Cc1ncc(-c2ccnc(Nc3ccc(C(=O)N4CC[C@H](NC5CC5)C4)cc3)n2)n1C(C)C CHEMBL460086 IC50 100.0 nM
CCCC(=O)Nc1n[nH]c2cc(Cl)c(-c3ccccc3)cc12 CHEMBL1095040 IC50 100.0 nM
CC(C)N(C)C(=O)c1c(-c2ccc3[nH]ncc3c2)nnn1Cc1ccccc1 CHEMBL1969561 pKi 100.0 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4cccc(OC(F)(F)F)c4)c3)cc12 CHEMBL1965836 pKi 100.0 nM
CN(C)CC(=O)Nc1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12 CHEMBL1965631 pKi 100.0 nM
NS(=O)(=O)c1cccc(Nc2nccc(-c3ccnc(N4C5CCC4COC5)c3)n2)c1 CHEMBL2158854 IC50 100.0 nM
Cc1cccc(Nc2nccc(-c3ccnc(N4CCOCC4)c3)n2)c1 CHEMBL2158848 IC50 100.0 nM
N#CCNc1nc(Nc2ccccc2)ncc1Br CHEMBL2203628 IC50 100.0 nM
Nc1ccccc1-c1ccc(CNc2nc(NC3CCC(N)CC3)nc3c2ncn3C2CCCC2)cn1 CHEMBL2403091 IC50 100.0 nM
Cc1nc2c(F)cc(-c3cc(Nc4cnc(CN5CCN(C6CCCC6)CC5)cn4)ncn3)cc2n1C(C)C CHEMBL4216534 IC50 100.5 nM
Cc1nc2c(F)cc(-c3cc(Nc4cnc(CN5CCN(CC6CC6)CC5)cn4)ncn3)cc2n1C(C)C CHEMBL4213557 IC50 103.1 nM
O=C(Nc1ccc(Cl)c(C(F)(F)F)c1)N1CCN(c2nnc(Cc3ccccc3)c3ccccc23)CC1 CHEMBL5414410 IC50 103.57 nM
Nc1nc2ccc(C(=O)c3c(F)cccc3Cl)cc2n1Cc1c(F)cccc1F CHEMBL1241662 IC50 104.0 nM
S=C(Nc1ccc(Cl)cc1)N1CCN(c2nnc(Cc3ccccc3)c3ccccc23)CC1 CHEMBL5418073 IC50 108.97 nM
CN1CCC(c2c(O)cc(O)c3c2O/C(=C\c2ccccc2)C3=O)CC1 CHEMBL51709 IC50 110.0 nM
NS(=O)(=O)c1ccc(/N=N/c2c(O)[nH]c3cccc(I)c23)cc1 CHEMBL314397 IC50 110.0 nM
CCNCc1cncc(-c2cnc3[nH]nc(-c4nc5c(COC)cccc5[nH]4)c3c2)c1C CHEMBL249519 IC50 110.0 nM
CCOC(=O)N=S(C)(=O)c1ccc(Nc2ncc(Br)c(N[C@@H](COC)[C@H](C)O)n2)cc1 CHEMBL3648087 IC50 110.0 nM
CC(C)Nc1nc(Nc2ccc(S(C)(=N)=O)cc2)ncc1Br CHEMBL3648126 IC50 110.0 nM
COc1cc(F)ccc1-c1ccnc2[nH]c(-c3ccc(CN4CCOCC4)cc3)cc12 CHEMBL5170195 IC50 110.0 nM
CN1CC[C@H](c2c(O)cc(O)c3c(=O)cc(Sc4ccccc4Cl)oc23)[C@H](O)C1 CHEMBL334881 IC50 110.0 nM
O=C(c1ccc(Cl)cc1)N1CCN(c2nnc(Cc3ccccc3)c3ccccc23)CC1 CHEMBL5423237 IC50 113.96 nM
COc1ccccc1-c1ccc(CNc2nc(NC3CCC(N)CC3)nc3c2ncn3C2CCCC2)cn1 CHEMBL2403092 IC50 118.0 nM
NC1CCC(Nc2nc(NCc3ccc(-c4cccs4)cc3)c3ncn(C4CCCC4)c3n2)CC1 CHEMBL2403086 IC50 119.0 nM
CCn1cnc2c(Nc3cccc(Cl)c3)nc(N[C@H]3CCC[C@@H](N)C3)nc21 CHEMBL368278 IC50 120.0 nM
NS(=O)(=O)c1ccc(N/N=C2\C(=O)Nc3ccc4[nH]ncc4c32)cc1 CHEMBL272833 IC50 120.0 nM
COCc1cccc2[nH]c(-c3n[nH]c4ncc(-c5cncc(CN(C)C)c5)cc34)nc12 CHEMBL249518 IC50 120.0 nM
COCc1cccc2[nH]c(-c3nn(C)c4ncc(-c5cncc6ccccc56)cc34)nc12 CHEMBL251740 IC50 120.0 nM
CCCN(C)[C@H]1CCN(C(=O)c2ccc(Nc3nccc(-c4cnc(C)n4C(C)C)n3)cc2)C1 CHEMBL518826 IC50 120.0 nM
O=C(Nc1cc(CN[C@H]2Cc3ccc(Cl)cc3C2)n[nH]1)Nc1cccc2c1[C@@H]1CCCN1C2=O CHEMBL336242 IC50 120.0 nM
O=C(Nc1ccccn1)Nc1cccc2c1[C@H]1CCCN1C2=O CHEMBL141247 IC50 122.0 nM
O=C(Nc1cccc(C(F)(F)F)n1)Nc1ccnc2c(F)cccc12 CHEMBL1966816 pKi 125.89 nM
CSc1cnc2c(ccc3cnccc32)c1O CHEMBL2006933 pKi 125.89 nM
NS(=O)(=O)c1ccc(Nc2cc(-c3ccc(Br)cc3)[nH]n2)cc1 CHEMBL319903 IC50 126.0 nM
Clc1cccc(CNc2nc(Nc3ccc4[nH]cnc4c3)ncc2Br)c1Cl CHEMBL192374 IC50 126.0 nM
COc1ccc(NC(=S)N2CCN(c3nnc(Cc4ccccc4)c4ccccc34)CC2)cc1 CHEMBL5424372 IC50 126.47 nM
CN(C)C(=O)c1ccc2c(c1)/C(=N/Nc1ccc(S(N)(=O)=O)cc1)C(=O)N2 CHEMBL409868 IC50 130.0 nM
NS(=O)(=O)c1ccc(N/N=C2\C(=O)Nc3ccc(S(=O)(=O)O)cc32)cc1 CHEMBL412091 IC50 130.0 nM
CCOC(=O)c1cccc2c1/C(=C/Nc1ccc(S(N)(=O)=O)cc1)C(=O)N2 CHEMBL408210 IC50 130.0 nM
Cc1cc(N2CCCS2(=O)=O)c2oc(-c3ccc(O)c(O)c3)c(O)c(=O)c2c1 CHEMBL232557 IC50 130.0 nM
Cc1ncc(-c2nc(Nc3ccc(C(=O)N4CCN(C)CC4)cc3)ncc2F)n1C(C)C CHEMBL451462 IC50 130.0 nM
CN1CC[C@H](c2c(O)cc(O)c3c(=O)cc(Oc4ccccc4Cl)oc23)[C@H](O)C1 CHEMBL133498 IC50 130.0 nM
C[C@@H](O)[C@@H](C)Nc1nc(Nc2ccc(S(C)(=N)=O)cc2)ncc1Br CHEMBL3648071 IC50 130.0 nM
C#CCOc1nc(Nc2ccc(S(C)(=O)=O)cc2)ncc1C(F)(F)F CHEMBL3644028 IC50 130.0 nM
COc1ccc(Cl)cc1C(=O)c1cnc(NC2CCN(S(C)(=O)=O)CC2)nc1N CHEMBL385373 Ki 133.0 nM
CCN1CCC(Cc2cnc(Nc3cc(-c4cc(F)c5nc(C)n(C(C)C)c5c4)ncn3)cn2)CC1 CHEMBL4207218 IC50 133.8 nM
Cc1ccccc1Sc1nc(Nc2ccc3[nH]cnc3c2)ncc1C(F)(F)F CHEMBL194124 IC50 135.0 nM
CCN1CCN(Cc2cnc(Nc3cc(-c4cc(F)c5nc(C)n(C(C)C)c5c4)ncn3)cn2)CC1 CHEMBL4208504 IC50 135.5 nM
COCCN1CCN(Cc2cnc(Nc3cc(-c4cc(F)c5nc(C)n(C(C)C)c5c4)ncn3)cn2)CC1 CHEMBL4214634 IC50 139.7 nM
CCn1cnc2c(Nc3cccc(C(F)(F)F)c3)nc(N[C@H]3CC[C@H](N)CC3)nc21 CHEMBL173608 IC50 140.0 nM
NS(=O)(=O)c1ccc(Nc2cc(OC3CCCCC3)nc3ncnn23)cc1 CHEMBL203407 IC50 140.0 nM
CC(C)n1cc(-c2ccnc3[nH]c(C4CCN(CC(=O)N5CCCCC5)CC4)cc23)ccc1=O CHEMBL5197170 IC50 140.0 nM
COc1ccc2sc3c(c2c1)NC[C@@H](CN)NC3=O CHEMBL555205 IC50 146.0 nM
C(=N/n1cccc1)\c1n[nH]c2cc(-c3ccncc3)ccc12 CHEMBL3894999 Ki 146.0 nM
NC1CCC(Nc2nc(NCc3ccc(-c4ccco4)cc3)c3ncn(C4CCCC4)c3n2)CC1 CHEMBL2403084 IC50 148.0 nM
CCC(C)(O)C#Cc1nc(NCc2ccc(N(C)C)cc2)c2ncn(C(C)C)c2n1 CHEMBL23525 IC50 150.0 nM
CCn1cnc2c(Nc3ccc(F)cc3)nc(N[C@@H]3CCCC[C@@H]3N)nc21 CHEMBL172848 IC50 150.0 nM
CCn1cnc2c(Nc3cccc(F)c3)nc(N[C@H]3CC[C@H](N)CC3)nc21 CHEMBL366642 IC50 150.0 nM
NS(=O)(=O)c1ccc(N/N=C2\C(=O)Nc3cccc(CCc4ccc(O)cc4)c32)cc1 CHEMBL411865 IC50 150.0 nM
NS(=O)(=O)c1ccc(N/N=C2\C(=O)Nc3ccc4[nH]nnc4c32)cc1 CHEMBL271952 IC50 150.0 nM
NS(=O)(=O)c1ccc(N/C=C2\C(=O)Nc3ccc(C(=O)O)cc32)cc1 CHEMBL272668 IC50 150.0 nM
NC1=NC(=O)/C(=C/c2ccc3ncccc3c2)S1 CHEMBL396377 Ki 150.0 nM
O=C(Cc1ccc(N2CCCCC2)cc1)Nc1n[nH]c2ccc(N3CCCS3(=O)=O)cc12 CHEMBL258040 IC50 150.0 nM
CC(C)n1cnc2ccc3nc(C(=N)OCc4ccccc4)sc3c2c1=O CHEMBL453129 IC50 150.0 nM
Cc1ncc(-c2ccnc(Nc3ccc(C(=O)NC4CCN(C)CC4)c(F)c3)n2)n1C(C)C CHEMBL453895 IC50 150.0 nM
COc1ccc2sc3c(c2c1)SCCNC3=O CHEMBL319170 IC50 150.0 nM
Cn1cc(Nc2ncc3cnn([C@@H]4C[C@H]5C[C@H]5C4)c3n2)cc1C(=O)N1CCC[C@@H]1CO CHEMBL2012413 IC50 150.0 nM
COC[C@H]1CCCN1C(=O)c1cc(Nc2ncc3cnn([C@@H]4C[C@H]5C[C@H]5C4)c3n2)cn1C CHEMBL2012414 IC50 150.0 nM
Cc1nc2c(F)cc(-c3cc(Nc4cnc(CN5CCN(CC(F)(F)F)CC5)cn4)ncn3)cc2n1C(C)C CHEMBL4214123 IC50 150.0 nM
Nc1ccccc1-c1ccc(CNc2nc(NC3CCC(N)CC3)nc3c2ncn3C2CCCC2)cc1 CHEMBL2402953 IC50 152.0 nM
NC1CCCCC1Nc1nccc(-c2c[nH]c3ncccc23)n1 CHEMBL1995813 pKi 158.49 nM
CCCS(=O)(=O)Nc1ccc(-c2ccc3[nH]nc(NC(=O)CC)c3c2)cc1 CHEMBL1972221 pKi 158.49 nM
CC(=NNC(=N)N)c1cc(NC(=O)c2cccc(C(=O)Nc3cc(C(C)=NNC(=N)N)cc(C(C)=NNC(=N)N)c3)c2)cc(C(C)=NNC(=N)N)c1 CHEMBL2000685 pKi 158.49 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4ccccc4)c3)cc12 CHEMBL2002726 pKi 158.49 nM
NC(COc1cncc(-c2cc3ccncc3s2)c1)Cc1c[nH]c2ccccc12 CHEMBL1966524 pKi 158.49 nM
CCn1cnc2c(Nc3cccc(OC)c3)nc(N[C@H]3CC[C@H](N)CC3)nc21 CHEMBL176834 IC50 160.0 nM
COc1cccc(Oc2nc(Nc3ccc4[nH]cnc4c3)ncc2C(F)(F)F)c1 CHEMBL371792 IC50 160.0 nM
Cc1cc(N2CCCS2(=O)=O)c2oc(-c3ccc(O)c(C#N)c3)c(O)c(=O)c2c1 CHEMBL233152 IC50 160.0 nM
COc1ccc2sc3c(c2c1)NCCNC3=O CHEMBL319171 IC50 160.0 nM
C[C@@H](Nc1nc(Nc2ccc(S(=O)(CC=O)=NS(=O)(=O)CC[Si](C)(C)C)cc2)ncc1Br)C(C)(C)O CHEMBL3648079 IC50 160.0 nM
C[C@H](O)[C@@H](C)Oc1nc(Nc2ccc(S(=O)(CCO)=NS(=O)(=O)CC[Si](C)(C)C)cc2)ncc1Br CHEMBL3648081 IC50 160.0 nM
Nc1ncc(-c2ccccc2)cc1-c1nc2ccccc2[nH]1 CHEMBL3799935 IC50 160.0 nM
CS(=N)(=O)c1ccc(Nc2ncc(Br)c(Nc3ccccc3)n2)cc1 CHEMBL3940661 IC50 160.0 nM
COc1cc(F)ccc1-c1ccnc2[nH]c(C3CCNCC3)cc12 CHEMBL3663760 IC50 160.0 nM
COc1ccc(Nc2nn3c(-c4ccccc4)cc(-c4ccccc4)nc3c2C(N)=O)c(OC)c1 CHEMBL5286623 IC50 161.2 nM
NC1CCC(Nc2nc(NCc3ccc(-c4ccsc4)nc3)c3ncn(C4CCCC4)c3n2)CC1 CHEMBL2403097 IC50 169.0 nM
NS(=O)(=O)c1ccc(N/N=C2\C(=O)Nc3cccc(/C=C/c4ccc(O)cc4)c32)cc1 CHEMBL272380 IC50 170.0 nM
CNS(=O)(=O)Cc1ccc(N/C=C2\C(=O)Nc3ccc4ncsc4c32)cc1 CHEMBL1964256 IC50 170.0 nM
NS(=O)(=O)c1ccc(N/N=C2\C(=O)Nc3ccc(S(N)(=O)=O)cc32)cc1 CHEMBL272387 IC50 170.0 nM
O=C1NCCc2[nH]c(-c3ccncc3)cc21 CHEMBL225519 IC50 170.0 nM
C[C@H](O)[C@@H](C)Nc1nc(Nc2ccc(S(=O)(CC=O)=NS(=O)(=O)CC[Si](C)(C)C)cc2)ncc1Br CHEMBL3648080 IC50 170.0 nM
CC(C)n1cnc2c(NCc3ccccc3)nc(C#CC3(O)CCCCC3)nc21 CHEMBL134239 IC50 180.0 nM
CCOc1ccc(CNc2nc(C#CC(C)(O)CC)nc3c2ncn3C(C)C)cc1 CHEMBL282330 IC50 180.0 nM
CN1CCN(CCc2ccc(Nc3ncc(Cl)c(-c4c[nH]c5ccccc45)n3)cc2)CC1 CHEMBL233224 IC50 180.0 nM
O=Nc1c(-c2c(O)[nH]c3ccccc23)[nH]c2ccccc12 CHEMBL126077 IC50 180.0 nM
Cc1ncc(-c2ccnc(Nc3ccc(C(=O)NC4CCN(C)CC4)cc3)n2)n1C(C)C CHEMBL455468 IC50 180.0 nM
CN1CCN(C(=O)c2cc(Nc3ncc4cc(-c5cnn(C)c5)n(C5CCCC5)c4n3)cn2C)CC1 CHEMBL2029909 IC50 180.0 nM
COc1ccccc1C(=O)c1cnc(NC2CCN(C(C)=O)CC2)nc1N CHEMBL217537 Ki 181.0 nM
NC1CCC(Nc2nc(NCc3ccc(-c4ccsc4)cc3)c3ncn(C4CCCC4)c3n2)CC1 CHEMBL2403087 IC50 183.0 nM
NC1CCC(Nc2nc(NCc3ccc(-c4ccccc4)nc3)c3ncn(C4CCCC4)c3n2)CC1 CHEMBL2403090 IC50 184.0 nM
COc1cc(F)ccc1C(=O)c1cnc(NC2CCN(S(C)(=O)=O)CC2)nc1N CHEMBL277351 Ki 193.0 nM
CCCC(=O)Nc1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3-c3ccccc3)cc12 CHEMBL2005936 pKi 199.53 nM
NS(=O)(=O)c1cccc(Nc2ncc3ccn(Cc4ccccc4)c3n2)c1 CHEMBL1993424 pKi 199.53 nM
NC(=O)c1cc2c(-c3cccc(F)c3)cncc2s1 CHEMBL1971017 pKi 199.53 nM
COc1cc2c(cc1OC)-c1[nH]c3ccc(Br)cc3c1CC(=O)N2 CHEMBL319373 IC50 200.0 nM
CCC(C)(O)C#Cc1nc(Nc2ccc(Cl)c(Cl)c2)c2ncn(C(C)C)c2n1 CHEMBL26513 IC50 200.0 nM
CCC(C)(O)C#Cc1nc(NCc2ccccc2)c2ncn(C(C)C)c2n1 CHEMBL26564 IC50 200.0 nM
CCC(C)(O)C#Cc1nc(NCc2ccc3c(c2)OCO3)c2ncn(C(C)C)c2n1 CHEMBL286491 IC50 200.0 nM
CCOc1ccc(Nc2nc(C#CC(C)(O)CC)nc3c2ncn3C(C)C)cc1 CHEMBL280623 IC50 200.0 nM
CC(C)n1cnc2c(NCc3ccccc3)nc(C#CCCCO)nc21 CHEMBL134080 IC50 200.0 nM
CCC(C)(O)C#Cc1nc(Nc2ccc(OC)cc2)c2ncn(C(C)C)c2n1 CHEMBL23317 IC50 200.0 nM
NS(=O)(=O)c1ccc(Nc2cc(-c3ccc(O)c(F)c3)n[nH]2)cc1 CHEMBL103115 IC50 200.0 nM
Oc1cccc(-c2[nH]nc3ncnc(Nc4cccc(Cl)c4)c23)c1 CHEMBL331906 IC50 200.0 nM
O=C1Nc2ccc3ncsc3c2/C1=C/Nc1ccc(CS(=O)(=O)NCCO)cc1 CHEMBL1964258 IC50 200.0 nM
CS(=O)(=O)c1ccc(CC(=O)Nc2n[nH]c3ccc(N4CCCS4(=O)=O)cc23)cc1 CHEMBL254170 IC50 200.0 nM
O=C1NC(=O)c2c1c(-c1ccccc1Cl)cc1[nH]c3cc(CCCCN4CCCC4)c(O)cc3c21 CHEMBL272946 IC50 200.0 nM
C[C@@H]1CNc2c(sc3ccc4nc(-c5ccccc5)ccc4c23)C(=O)N1 CHEMBL564076 IC50 200.0 nM
COc1c(O)cc2c3c(cc4ccc(O)cc4c13)NC2=O CHEMBL388956 IC50 200.0 nM
COc1ccc2nc3[nH]nc(C)c3c(OC)c2c1 CHEMBL603097 IC50 200.0 nM
CN1CCN(C(=O)c2cc(Nc3ncc4cc(-c5cncn5C)n(C5CCCC5)c4n3)cn2C)CC1 CHEMBL2029910 IC50 200.0 nM
CCOC(=O)N=S(=O)(CC)c1ccc(Nc2ncc(Br)c(N[C@@H](COC)[C@H](C)O)n2)cc1 CHEMBL3648086 IC50 200.0 nM
CCOc1nc(Nc2ccc(S(=N)(=O)CC)cc2)ncc1Br CHEMBL3648097 IC50 200.0 nM
COc1cc(C(=O)N2CCCC2)ccc1-c1ccnc2[nH]c(C3CCNCC3)cc12 CHEMBL5170524 IC50 200.0 nM
NC1CCC(Nc2nc(NCc3ccc(-c4ccoc4)cc3)c3ncn(C4CCCC4)c3n2)CC1 CHEMBL2403085 IC50 202.0 nM
COc1ccc(CNc2nc(N3CCC[C@@H]3CO)nc3c2ncn3C(C)C)cc1 CHEMBL3085238 IC50 210.0 nM
COc1ccc2c(c1)/C(=N/Nc1ccc(S(N)(=O)=O)cc1)C(=O)N2 CHEMBL260103 IC50 210.0 nM
CNC(=O)Nc1ccc(-c2cc(-c3ccnc(Nc4cccc(S(=O)(=O)NC)c4)n3)ccn2)cc1 CHEMBL2158859 IC50 210.0 nM
O=C1Nc2cc3c(O)cccc3c3c4c(cc1c23)OCO4 CHEMBL609040 IC50 214.0 nM
OC1CCC(Nc2nc(NCc3ccc(-c4ccco4)nc3)c3ncn(C4CCCC4)c3n2)CC1 CHEMBL2403098 IC50 215.0 nM
CSc1ccc(Nc2nc(N)c(N=O)c(OCC3CCCCC3)n2)cc1 CHEMBL322568 IC50 220.0 nM
C/C(Nc1ccc(S(N)(=O)=O)cc1)=C1/C(=O)Nc2ccc(Cl)cc21 CHEMBL412097 IC50 220.0 nM
CCC(CO)Nc1nc(Nc2cccc(-c3ccccn3)c2)c2ncn(C(C)C)c2n1 CHEMBL1080583 IC50 220.0 nM
Nc1nc(-c2cc(N3C[C@H](O)[C@@H](O)C3)ccc2O)cc(C2CCCNC2)n1 CHEMBL1800458 IC50 220.0 nM
C(=C/c1n[nH]c2cc(-c3ccncc3)ccc12)\c1ccccc1 CHEMBL3979164 Ki 223.0 nM
CCC(C)(O)C#Cc1nc(NCc2ccc(OC)cc2)c2ncn(C(C)C)c2n1 CHEMBL422759 IC50 230.0 nM
COc1ccc(Nc2nc(N)c(N=O)c(OCC3CCCCC3)n2)cc1 CHEMBL102636 IC50 230.0 nM
CCn1cnc2c(Nc3cccc(OC)c3)nc(N[C@@H]3CCCC[C@@H]3N)nc21 CHEMBL175143 IC50 230.0 nM
NS(=O)(=O)c1ccc(N/N=C2\C(=O)Nc3ccc(C(=O)NCCCn4ccnc4)cc32)cc1 CHEMBL272026 IC50 230.0 nM
CNC(=O)Nc1ccc(-c2cc(-c3ccnc(Nc4ccc(C)c(S(=O)(=O)NC)c4)n3)ccn2)cc1 CHEMBL2158862 IC50 230.0 nM
CCN1CCC(Oc2cnc(Nc3cc(-c4cc(F)c5nc(C)n(C(C)C)c5c4)ncn3)cn2)CC1 CHEMBL4208875 IC50 230.7 nM
NC1CCC(Nc2nc(NCc3ccc(-c4ccccc4)cc3)c3ncn(C4CCCC4)c3n2)CC1 CHEMBL2402952 IC50 232.0 nM
O=C1Cc2c([nH]c3ccc(C(F)(F)F)cc23)-c2cc(Br)ccc2N1 CHEMBL100309 IC50 240.0 nM
CCN1CCOCCn2cc(c3ccccc32)C2=C(C(=O)NC2=O)c2cn(c3ccccc23)CCOCC1 CHEMBL103055 IC50 240.0 nM
CCNc1nc(C)c(-c2ccnc(Nc3ccc(CNC(C)=O)cc3)n2)s1 CHEMBL1084715 Ki 240.0 nM
CN1CCN(C(=O)c2cc(Nc3ncc4ccn(C5CCCC5)c4n3)cn2C)CC1 CHEMBL2029902 IC50 240.0 nM
CCOC(=O)N1CCC(Nc2ncc(C(=O)c3ccccc3OC)c(N)n2)CC1 CHEMBL217443 Ki 246.0 nM
Brc1cnc(Nc2ccc(Oc3cccnc3)cc2)nc1Nc1ccc2[nH]cnc2c1 CHEMBL195831 IC50 248.0 nM
CCn1cnc2c(Nc3cccc(F)c3)nc(N[C@@H]3CCCC[C@@H]3N)nc21 CHEMBL173737 IC50 250.0 nM
NS(=O)(=O)c1ccc(N/N=C2\C(=O)Nc3cccc(-c4cc[nH]n4)c32)cc1 CHEMBL272684 IC50 250.0 nM
Cc1ccc2c(c1Cl)/C(=N/Nc1ccc(S(N)(=O)=O)cc1)C(=O)N2 CHEMBL411490 IC50 250.0 nM
O=C1NC(=O)c2c1c(-c1ccccc1Cl)cc1c2c2cc(O)ccc2n1CCCO CHEMBL411662 IC50 250.0 nM
O=C1NC(=O)c2c1c(-c1ccccc1Cl)cc1c2c2cc(O)c(OCCCN3CCOCC3)cc2n1CCO CHEMBL271715 IC50 250.0 nM
CN(C)CCCOc1cc2c(cc1O)c1c3c(c(-c4ccccc4Cl)cc1n2CCO)C(=O)NC3=O CHEMBL401776 IC50 250.0 nM
O=C1NC(=O)c2c1c(-c1ccccc1Cl)cc1[nH]c3cc(CCCCN4CCOCC4)c(O)cc3c21 CHEMBL403679 IC50 250.0 nM
CN(C)CCCCc1cc2[nH]c3cc(-c4ccccc4Cl)c4c(c3c2cc1O)C(=O)NC4=O CHEMBL401746 IC50 250.0 nM
O=C1NC(=O)c2c1c1c3ccccc3n3c1c1c2c2ccccc2n1C1CCC3O1 CHEMBL304428 IC50 250.0 nM
O=C1NC(=O)c2c1c(-c1ccccc1Cl)cc1c2c2cc(O)ccc2n1CCN1CCOCC1 CHEMBL529669 IC50 250.0 nM
CN(C)CC(O)Cn1c2ccc(O)cc2c2c3c(c(-c4ccccc4Cl)cc21)C(=O)NC3=O CHEMBL517744 IC50 250.0 nM
CS(=O)(=O)NC(=O)CCn1c2ccc(O)cc2c2c3c(c(-c4ccccc4Cl)cc21)C(=O)NC3=O CHEMBL460940 IC50 250.0 nM
C[C@@H]1CNc2c(sc3ccc4oc(-c5ccccc5)cc4c23)C(=O)N1 CHEMBL562194 IC50 250.0 nM
N[C@H](CNc1ncc(-c2ccc3c(c2)CC(=O)N3)s1)Cc1ccc(C(F)(F)F)cc1 CHEMBL1081831 IC50 250.0 nM
COc1cc(-c2ccc3c(c2)NC(=O)/C3=C\c2ncc[nH]2)ccc1O CHEMBL199299 IC50 251.0 nM
O=C1NCCc2[nH]c(-c3ccnc(C=Cc4ccccc4)c3)cc21 CHEMBL1997129 pKi 251.19 nM
NC(=O)c1cc2c(-c3ccc(Br)c(F)c3F)cncc2s1 CHEMBL1999918 pKi 251.19 nM
NC(=O)c1cc(-c2ccnc(N)n2)[nH]c1-c1ccc(Cl)cc1F CHEMBL1981079 pKi 251.19 nM
COc1cc(-c2ccc3c(c2)Nc2ccc(C(=O)NCCNC(C)=O)cc2NC3=O)ccc1O CHEMBL1975500 pKi 251.19 nM
COc1ccc(Nc2nccc(Nc3c(NC(C)C(C)(C)C)c(=O)c3=O)n2)cc1OC CHEMBL1964399 pKi 251.19 nM
O=C(Nc1n[nH]c2nc3ccccc3cc12)c1ccncc1 CHEMBL1990415 pKi 251.19 nM
COc1ccc(-c2cnc3c(Br)cnn3c2)cc1 CHEMBL443962 pKi 251.19 nM
CC(C)Cc1cc(-c2ccc3[nH]nc(N)c3c2)on1 CHEMBL1966343 pKi 251.19 nM
NC(COc1cncc(-c2ccc3c(c2)C(=Cc2ccco2)C(=O)N3)c1)Cc1c[nH]c2ccccc12 CHEMBL2001751 pKi 251.19 nM
CCCCOc1ncnc2[nH]cc(-c3ccccc3)c12 CHEMBL1996817 pKi 251.19 nM
Nc1nnc(-c2cc3c(Oc4ccc(Cl)cc4)cncc3s2)o1 CHEMBL1994830 pKi 251.19 nM
CSc1ccccc1CNc1ncc([N+](=O)[O-])c(NCC2CCC(CN)CC2)n1 CHEMBL392642 pKi 251.19 nM
FC(F)(F)c1cnc(Nc2ccc3[nH]cnc3c2)nc1Oc1ccc(Cl)cc1 CHEMBL195595 IC50 252.0 nM
Oc1ccc(-c2[nH]nc3ncnc(Nc4cccc(Cl)c4)c23)cc1 CHEMBL118130 IC50 260.0 nM
COc1ccc2sc3c(c2c1)NC[C@H](C)NC3=O CHEMBL100818 IC50 260.0 nM
CCCCCCc1cc(-c2cc(N3C[C@H](O)[C@@H](O)C3)ccc2O)nc(N)n1 CHEMBL1800453 IC50 260.0 nM
CC(C)n1cc(-c2ccnc3[nH]c(C4CCN(CC(=O)N5CCCC5)CC4)cc23)ccc1=O CHEMBL5207871 IC50 270.0 nM
CCCC(=O)N1CCC(Nc2ncc(C(=O)c3ccccc3OC)c(N)n2)CC1 CHEMBL384356 Ki 278.0 nM
O=C(Cc1ccc2ccccc2c1)Nc1cc(C2CC2)n[nH]1 CHEMBL115220 IC50 279.0 nM
COc1cc2c(cc1OC)-c1[nH]c3ccc(C(F)(F)F)cc3c1CC(=O)N2 CHEMBL328194 IC50 280.0 nM
CN(C)c1cc(-c2cc(N3C[C@H](O)[C@@H](O)C3)ccc2O)nc(N)n1 CHEMBL1800460 IC50 280.0 nM
C=CCOc1nc(Nc2ccc(S(C)(=O)=O)cc2)ncc1C(F)(F)F CHEMBL3644030 IC50 280.0 nM
CC(=O)c1cnc2ccc(-c3cc(Cl)c(O)c(Cl)c3)nc2c1N[C@H]1CC[C@H](CN(C)C)CC1 CHEMBL3688339 Kd apparent 288.0 nM
CCn1cnc2c(Nc3cccc(C(F)(F)F)c3)nc(N[C@H]3CC[C@@H](N)CC3)nc21 CHEMBL174162 IC50 290.0 nM
NS(=O)(=O)c1ccc(N/N=C2\C(=O)Nc3cccc(Oc4ccccc4)c32)cc1 CHEMBL409104 IC50 290.0 nM
NS(=O)(=O)c1ccc(N/N=C2\C(=O)Nc3cccc(CCc4ccncc4)c32)cc1 CHEMBL1794054 IC50 290.0 nM
NS(=O)(=O)c1ccc(N/N=C2\C(=O)Nc3ccc(F)cc32)cc1 CHEMBL273061 IC50 290.0 nM
NS(=O)(=O)c1ccc(N/N=C2\C(=O)Nc3cccc(OCCc4ccncc4)c32)cc1 CHEMBL272217 IC50 290.0 nM
O=C1Cc2c([nH]c3ccc(Br)cc23)-c2cc(Br)ccc2N1 CHEMBL98360 IC50 300.0 nM
CCC(C)(O)C#Cc1nc(NCc2ccc(OC)c(OC)c2)c2ncn(C(C)C)c2n1 CHEMBL281525 IC50 300.0 nM
COc1cccc(CNc2nc(N3CCC[C@@H]3CO)nc3c2ncn3C(C)C)c1 CHEMBL3085240 IC50 300.0 nM
COc1cc(CNc2nc(N3CCC[C@@H]3CO)nc3c2ncn3C(C)C)cc(OC)c1 CHEMBL3085235 IC50 300.0 nM
CC(C)n1cnc2c(Nc3ccccc3)nc(N3CCC[C@@H]3CO)nc21 CHEMBL3085243 IC50 300.0 nM
CCCCNc1nc(C#CC(C)(O)Cc2ccccc2)nc2c1ncn2C(C)C CHEMBL133461 IC50 300.0 nM
CC(C)n1cnc2c(Nc3ccc(Br)cc3)nc(N3CCCC3CO)nc21 CHEMBL334507 IC50 300.0 nM
NS(=O)(=O)c1ccc(N/N=C2\C(=O)Nc3ccc(Cl)cc32)cc1 CHEMBL270054 IC50 300.0 nM
CC(C)n1cc(-c2ccnc3[nH]c(C4CCN(CC(=O)N(C)C)CC4)cc23)ccc1=O CHEMBL5198038 IC50 300.0 nM
CCN1CCN(Cc2ccc(Nc3cc(-c4cc(F)c5nc(C)n(C(C)C)c5c4)ccn3)nc2)CC1 CHEMBL4208198 IC50 300.9 nM
COc1ccccc1-c1ccc(CNc2nc(NC3CCC(N)CC3)nc3c2ncn3C2CCCC2)cc1 CHEMBL2402954 IC50 301.0 nM
CCn1cnc2c(Nc3cccc(C(F)(F)F)c3)nc(N[C@@H]3CCCC[C@@H]3N)nc21 CHEMBL176576 IC50 310.0 nM
Clc1cc2nn[nH]c2cc1Cl CHEMBL1996923 pKi 316.23 nM
COc1ccc2c(c1)C(=Cc1c[nH]cn1)C(=O)N2 CHEMBL2002649 pKi 316.23 nM
c1cc2cc(-c3ccc4cn[nH]c4c3)cnc2[nH]1 CHEMBL1976134 pKi 316.23 nM
Nc1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3-c3ccccc3)cc12 CHEMBL1972158 pKi 316.23 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(CN)Cc4ccccc4)c3)cc12 CHEMBL2000271 pKi 316.23 nM
Cc1ccc(NC(=O)Nc2ccc(-c3csc4ncnc(N)c34)cc2)cc1C CHEMBL2000335 pKi 316.23 nM
COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 CHEMBL509032 pKi 316.23 nM
Nc1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12 CHEMBL1682346 pKi 316.23 nM
NCCn1cc(-c2cc(-c3cc4ccccc4s3)c3[nH]ncc3c2)c2nc(N)ncc21 CHEMBL590109 pKi 316.23 nM
OC1CCN(c2ncnc3[nH]cc(-c4ccccc4)c23)CC1 CHEMBL1973395 pKi 316.23 nM
NC(=O)c1cc2c(-c3ccc(F)cc3F)cncc2s1 CHEMBL1975787 pKi 316.23 nM
O=C1Nc2cc(Br)ccc2/C1=C1/Nc2ccccc2/C1=N\O CHEMBL409450 IC50 320.0 nM
CNC(=O)Nc1ccc(-c2cc(-c3ccnc(Nc4ccc(Cl)c(S(=O)(=O)NC)c4)n3)ccn2)cc1 CHEMBL2158864 IC50 320.0 nM
CC(C)n1cnc2c(NCc3ccc(Cl)cc3)nc(N3CCC[C@@H]3CO)nc21 CHEMBL3085241 IC50 330.0 nM
CC(C)n1cnc2c(NCc3ccccc3)nc(C#CCCCCO)nc21 CHEMBL132469 IC50 330.0 nM
CC(C)n1cnc2c(NCc3cccc(Br)c3)nc(N3CCC[C@@H]3CO)nc21 CHEMBL3085236 IC50 330.0 nM
CCn1cnc2c(Nc3cccc(Cl)c3)nc(NCCO)nc21 CHEMBL367245 IC50 330.0 nM
Cc1ccc2c(c1)/C(=N/Nc1ccc(S(N)(=O)=O)cc1)C(=O)N2 CHEMBL271843 IC50 330.0 nM
Cc1c(-c2cc3cnc(Nc4cc(C(=O)N5CCN(C)CC5)n(C)c4)nc3n2C2CCCC2)cnn1C CHEMBL2029911 IC50 330.0 nM
CN(C)CCc1ccc(Nc2ncc(Cl)c(-c3cccc4cc[nH]c34)n2)cc1 CHEMBL234626 IC50 334.0 nM
CCn1cnc2c(Nc3cccc(OC)c3)nc(N[C@H]3CC[C@@H](N)CC3)nc21 CHEMBL172811 IC50 340.0 nM
Nc1nc(-c2cc(N3C[C@H](O)[C@@H](O)C3)ccc2O)cc(C2CCNCC2)n1 CHEMBL1800459 IC50 340.0 nM
OCCCNc1cncc(-c2ncnc(Nc3ccc4c(c3)OCCO4)n2)c1 CHEMBL363590 IC50 344.0 nM
COc1ccc(F)cc1-c1c(F)cnc2[nH]c(C3=CCN([C@H]4CC[C@H](C(=O)O)CC4)CC3)cc12 CHEMBL4777981 IC50 348.0 nM
CC(C)n1cnc2c(NCc3ccccc3)nc(C#CCCO)nc21 CHEMBL337411 IC50 350.0 nM
CC(C)n1cnc2c(NCc3ccc4c(c3)OCO4)nc(N3CCC[C@@H]3CO)nc21 CHEMBL3085237 IC50 350.0 nM
CCn1cnc2c(Nc3cccc(C#N)c3)nc(N[C@@H]3CCCC[C@@H]3N)nc21 CHEMBL366620 IC50 350.0 nM
CCn1cnc2c(Nc3cccc(F)c3)nc(N[C@H]3CC[C@@H](N)CC3)nc21 CHEMBL173353 IC50 350.0 nM
CCn1cnc2c(Nc3cccc(C#N)c3)nc(N[C@H]3CC[C@@H](N)CC3)nc21 CHEMBL176908 IC50 350.0 nM
CN(C)c1ccc(Nc2[nH]nc3ncnc(Nc4cccc(Cl)c4)c23)cc1 CHEMBL332765 IC50 350.0 nM
CS(=O)(=O)c1ccc2c(c1)/C(=N/Nc1ccc(S(N)(=O)=O)cc1)C(=O)N2 CHEMBL272389 IC50 350.0 nM
Cc1ccc(-c2ccc3c(ccc4sc5c(c43)NC[C@@H](C)NC5=O)n2)cn1 CHEMBL1231206 IC50 354.0 nM
COc1ccc2sc3c(c2c1)CCCNC3=O CHEMBL571897 IC50 360.0 nM
CC(C)(C)c1nc(-c2cccc(NS(=O)(=O)c3c(F)cccc3F)c2F)c(-c2ccnc(N)n2)s1 CHEMBL2028663 Kd apparent 364.0 nM
CNc1nc(C)c(-c2ccnc(Nc3cc(OC)c(OC)c(OC)c3)n2)s1 CHEMBL1083152 Ki 367.0 nM
CC(=O)N[C@@H]1CCC[C@H](C(=O)Nc2cc(-c3cnn4c3CC(C)(C)C4)c(Cl)cn2)C1 CHEMBL4462530 IC50 370.0 nM
CCn1cnc2c(Nc3ccc(F)cc3)nc(NCCO)nc21 CHEMBL367614 IC50 380.0 nM
C[C@@H]1CNc2c(sc3ccc4nc(-c5ccncc5)ccc4c23)C(=O)N1 CHEMBL552339 IC50 390.0 nM
Cn1cc(Nc2ncc3cnn([C@@H]4C[C@H]5C[C@H]5C4)c3n2)cc1C(=O)N1CCC[C@@H]1CN1CCOCC1 CHEMBL2012415 IC50 390.0 nM
Fc1cccc(/C=C/c2n[nH]c3cc(-c4ccncc4)ccc23)c1 CHEMBL3932994 Ki 390.0 nM
COc1cc(C(=O)N2CCCC2)ccc1-c1ccnc2[nH]c(-c3ccc(CN4CCOCC4)cc3)nc12 CHEMBL5173041 IC50 390.0 nM
Brc1cnc(Nc2ccc3[nH]cnc3c2)nc1NC1CCCc2ccccc21 CHEMBL362967 IC50 392.0 nM
NS(=O)(=O)c1ccc(Nc2cc(-c3cccc(O)c3)n[nH]2)cc1 CHEMBL103104 IC50 398.0 nM
COc1cccc(-c2cc(Nc3ccc(S(N)(=O)=O)cc3)[nH]n2)c1 CHEMBL319685 IC50 398.0 nM
O=C(Nc1cnccn1)Nc1ccnc2c(F)cccc12 CHEMBL1975647 pKi 398.11 nM
CC(C)(C)c1ccc2nc(-c3n[nH]c4ccccc34)[nH]c2c1 CHEMBL1970104 pKi 398.11 nM
OCC(CO)Nc1ncnc2[nH]cc(-c3ccccc3)c12 CHEMBL1992922 pKi 398.11 nM
Cc1c(-c2ccc3[nH]nc(N)c3c2)nnn1Cc1ccccc1 CHEMBL1989646 pKi 398.11 nM
Cc1nc(N)sc1-c1ccnc(Nc2ccc(N3CCOCC3)cc2)n1 CHEMBL482967 pKi 398.11 nM
COCCOC1CCC(n2nc(-c3ccc(Nc4nc5cc(C)cc(C)c5o4)cc3)c3c(N)ncnc32)CC1 CHEMBL1984162 pKi 398.11 nM
CCCS(=O)(=O)Nc1ccc(-c2ccc3[nH]nc(NC(C)=O)c3c2)cc1 CHEMBL1973893 pKi 398.11 nM
COc1cc(Nc2ncc(F)c(Nc3ccc4c(n3)NC(=O)C(C)(C)O4)n2)cc(OC)c1OC CHEMBL475251 pKi 398.11 nM
Cc1cccc(Nc2nccc(Nc3c(NC(C)C(C)(C)C)c(=O)c3=O)n2)c1 CHEMBL1969523 pKi 398.11 nM
NCC(NC(=O)c1ccc(-c2ccncc2)cc1)c1ccccc1 CHEMBL1990254 pKi 398.11 nM
Brc1cnc2[nH]cc(-c3ccccc3)c2c1 CHEMBL1992634 pKi 398.11 nM
Cc1ccc(Nc2nc3ccc([N+](=O)[O-])cc3[nH]2)nc1 CHEMBL1992937 pKi 398.11 nM
Cc1ccccc1NC(=O)Nc1ccc(NC(=O)c2csc3ncnc(N)c23)cc1 CHEMBL1980144 pKi 398.11 nM
O=C1Cc2c([nH]c3ccc(Br)cc23)-c2ccccc2N1 CHEMBL296586 IC50 400.0 nM
O=C1Cc2c([nH]c3ccc(C(F)(F)F)cc23)-c2ccccc2N1 CHEMBL329505 IC50 400.0 nM
CCC(C)(O)C#Cc1nc(Nc2ccccc2)c2ncn(C(C)C)c2n1 CHEMBL284899 IC50 400.0 nM
CCC(C)(O)C#Cc1nc(NCCc2ccc(OC)cc2)c2ncn(C(C)C)c2n1 CHEMBL336283 IC50 400.0 nM
N#Cc1cnc(Nc2ccc(CCO)cc2)nc1-c1ccc2[nH]ccc2c1 CHEMBL389102 IC50 410.0 nM
CCN1CCN(Cc2ccc(Nc3cc(-c4cc(F)c5nc(C)n(C(C)C)c5c4)ncn3)nc2)CC1 CHEMBL4214898 IC50 411.9 nM
CN1CCN(c2cc(-c3cc(N4C[C@H](O)[C@@H](O)C4)ccc3O)nc(N)n2)CC1 CHEMBL1800462 IC50 420.0 nM
NC1CCC(Nc2nc(NCc3ccc(-c4cccc(F)c4)cc3)c3ncn(C4CCCC4)c3n2)CC1 CHEMBL2403083 IC50 422.0 nM
CC(C)n1cnc2c(Nc3ccc(Cl)c(Cl)c3)nc(N3CCC[C@@H]3CO)nc21 CHEMBL3085248 IC50 430.0 nM
CC(C)n1cnc2c(Nc3cccc(Cl)c3)nc(N3CCC[C@@H]3CO)nc21 CHEMBL77369 IC50 430.0 nM
CCC(C)(O)C#Cc1nc(NCc2ccc(Cl)c(Cl)c2)c2ncn(C(C)C)c2n1 CHEMBL25840 IC50 430.0 nM
CC(C)n1cnc2c(NCc3ccc(Cl)c(Cl)c3)nc(N3CCC[C@@H]3CO)nc21 CHEMBL3085245 IC50 430.0 nM
Fc1cnc(Nc2ccc3[nH]cnc3c2)nc1Nc1ccc2[nH]cnc2c1 CHEMBL194028 IC50 430.0 nM
Cc1nn(C2CCN(C(=O)[C@@H](C)O)CC2)c(C)c1Nc1ncc(Cl)c(-c2cnn3ccccc23)n1 CHEMBL3823030 IC50 430.0 nM
Cc1nc(C)c(-c2nc(Nc3ccc(CCN(C)C)cc3)ncc2Cl)s1 CHEMBL234451 IC50 439.0 nM
CCn1cnc2c(Nc3cccc(F)c3)nc(NCCO)nc21 CHEMBL171975 IC50 440.0 nM
CC(C)n1cnc2c(NCc3cccc(I)c3)nc(N3CCC[C@@H]3CO)nc21 CHEMBL3085252 IC50 450.0 nM
CCn1cnc2c(Nc3ccc(F)cc3)nc(NCCN)nc21 CHEMBL540874 IC50 450.0 nM
CCn1cnc2c(Nc3ccc(F)cc3)nc(NCCN)nc21 CHEMBL176488 IC50 450.0 nM
Cc1cc(N2CCCS2(=O)=O)c2oc(-c3ccc(O)cc3)c(O)c(=O)c2c1 CHEMBL232749 IC50 450.0 nM
O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12 CHEMBL50 IC50 450.0 nM
COc1cc(-c2ccc3c(c2)NC(=O)/C3=C\c2c[nH]c3ncccc23)ccc1O CHEMBL383316 IC50 454.0 nM
CN(C)CCc1ccc(Nc2ncc(Cl)c(-c3cccs3)n2)cc1 CHEMBL233380 IC50 461.0 nM
CCOC(=O)CCC(=O)NS(=O)(=O)c1ccc(Nc2nc(N)n(C(=O)c3c(F)cccc3F)n2)cc1 CHEMBL379193 IC50 466.0 nM
N#Cc1cnc(Nc2ccc(CCO)cc2)nc1-c1cccs1 CHEMBL245174 IC50 470.0 nM
CC(C)(C)c1cnc(CSc2cnc(NC(=O)C3CCNCC3)s2)o1 CHEMBL296468 Ki 480.0 nM
Nc1nc(Nc2ccc(S(=O)(=O)NC(=O)CCC(=O)O)cc2)nn1C(=O)c1c(F)cccc1F CHEMBL209280 IC50 494.0 nM
CC(C)n1cnc2c(NCc3ccccc3)nc(C#CC3(O)CCCC3)nc21 CHEMBL336776 IC50 500.0 nM
CCC(O)C#Cc1nc(NCc2ccccc2)c2ncn(C(C)C)c2n1 CHEMBL445125 IC50 500.0 nM
COc1ccc(CNc2nc(C#CC3(O)CCCCCC3)nc3c2ncn3C(C)C)cc1 CHEMBL436368 IC50 500.0 nM
OCCCNc1cc(-c2cncc(Nc3cccc(Cl)c3)n2)ccn1 CHEMBL177434 IC50 500.0 nM
CN1CCN(C(=O)c2cc(Nc3ncc4cc(C(N)=O)n(C5CCCC5)c4n3)cn2C)CC1 CHEMBL2029903 IC50 500.0 nM
CN(C)C(=O)c1cccc(-c2cnc(N)c(-c3nc4cccc(N5CCNCC5)c4n3C)n2)c1 CHEMBL3798762 IC50 500.0 nM
Nc1ccc(-c2cc(Nc3ccc(S(N)(=O)=O)cc3)[nH]n2)cc1 CHEMBL321517 IC50 501.0 nM
NS(=O)(=O)c1ccc(Nc2cc(-c3cccc(NS(=O)(=O)c4ccccc4)c3)[nH]n2)cc1 CHEMBL319103 IC50 501.0 nM
CS(=O)(=O)Nc1cccc(-c2cc(Nc3ccc(S(N)(=O)=O)cc3)[nH]n2)c1 CHEMBL421578 IC50 501.0 nM
c1ccc(Cn2cc(-c3ccc4[nH]ncc4c3)nn2)cc1 CHEMBL1682345 pKi 501.19 nM
OCCNc1cc2cc(-c3cccnc3)ccc2cn1 CHEMBL1990912 pKi 501.19 nM
CNC(=O)COc1ccc(Nc2nc(Nc3ccc(C)c(S(N)(=O)=O)c3)ncc2F)cc1 CHEMBL1978099 pKi 501.19 nM
CC(=O)Nc1cccc(CNc2c(Nc3ccc4[nH]ncc4c3)c(=O)c2=O)c1 CHEMBL1988608 pKi 501.19 nM
COCCN(C)C(=O)c1c(-c2ccc3[nH]ncc3c2)nnn1Cc1ccccc1 CHEMBL1986970 pKi 501.19 nM
NC(=O)c1sc2c(Br)ccc(Cl)c2c1N CHEMBL1998611 pKi 501.19 nM
CS(=O)(=O)NCCOc1cncc(-c2ccc3cnccc3c2)c1 CHEMBL1964804 pKi 501.19 nM
Cc1ccc2nccc(NC(=O)Nc3cccc(C(F)(F)F)n3)c2c1 CHEMBL1964444 pKi 501.19 nM
COc1ccc(C=NNc2ncnc3c2[nH]c2ccccc23)cc1OC CHEMBL1974664 pKi 501.19 nM
COc1ccc(-c2cc3nccn3c(Nc3ncccc3C(N)=O)n2)cc1OC CHEMBL1190711 pKi 501.19 nM
CCCC(=O)Nc1nn(C(=O)CC)c2nc3ccccc3cc12 CHEMBL1970913 pKi 501.19 nM
COc1cc(C=C(C#N)c2nc3ccccc3[nH]2)c(Br)cc1O CHEMBL1994241 pKi 501.19 nM
Nc1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3-c3ccc(F)cc3)cc12 CHEMBL1986499 pKi 501.19 nM
Cc1n[nH]c2ncc(C#N)c(-c3ccccc3)c12 CHEMBL1965495 pKi 501.19 nM
O=C(O)c1ccccc1Nc1ccnc(Nc2cccc(O)c2)n1 CHEMBL243088 pKi 501.19 nM
NS(=O)(=O)c1ccc(N/N=C2\C(=O)Nc3cc(Br)ccc32)cc1 CHEMBL271183 IC50 520.0 nM
COc1ccc(NC(=S)NC(=O)c2cn(-c3ccccc3)nc2-c2ccc(OC)cc2)cc1 CHEMBL2426395 IC50 522.0 nM
CN1CCN(C(=O)c2ccc3cc(CCNc4ncnc5ccc(C#N)cc45)ccc3c2)CC1 CHEMBL4076837 EC50 530.0 nM
CN(C)CCc1ccc(Nc2ncc(Cl)c(-c3cccc4[nH]ccc34)n2)cc1 CHEMBL392743 IC50 540.0 nM
O=C(O)c1cccc2[nH]c(-c3n[nH]c4ncc(-c5cncc6ccccc56)cc34)nc12 CHEMBL249501 IC50 540.0 nM
COc1cc(F)ccc1-c1ccnc2[nH]c(-c3ccc(CN4CCOCC4)cc3)nc12 CHEMBL5188442 IC50 540.0 nM
CCn1cnc2c(Nc3cccc(OC)c3)nc(NCCN)nc21 CHEMBL366698 IC50 550.0 nM
CCn1cnc2c(Nc3ccc(OC)cc3)nc(NCCN)nc21 CHEMBL368743 IC50 550.0 nM
CCOc1cccc2c1/C(=N/Nc1ccc(S(N)(=O)=O)cc1)C(=O)N2 CHEMBL411696 IC50 550.0 nM
Cn1cc(C2=C(c3ccc(Cl)cc3Cl)C(=O)NC2=O)c2ccccc21 CHEMBL102714 IC50 550.0 nM
CC(C)(O)CNc1nc(NCc2ccc(-c3ccco3)nc2)c2ncn(C3CCCC3)c2n1 CHEMBL2403099 IC50 555.0 nM
CCn1cnc2c(Nc3cccc(C#N)c3)nc(NCCN)nc21 CHEMBL175158 IC50 560.0 nM
CCn1cnc2c(Nc3cccc(C#N)c3)nc(NCCN)nc21 CHEMBL557975 IC50 560.0 nM
N#Cc1cnc(Nc2ccc(CCO)cc2)nc1-c1nc2ccccc2s1 CHEMBL234489 IC50 560.0 nM
FC(F)(F)c1cnc(Nc2ccc3[nH]cnc3c2)nc1Oc1ccc(Br)cc1 CHEMBL193936 IC50 562.0 nM
COc1ccc(NC(=S)NC(=O)c2cn(-c3ccccc3)nc2-c2ccc(F)cc2)cc1 CHEMBL2426391 IC50 569.0 nM
COc1ccc(NC(=S)NC(=O)c2cn(-c3ccccc3)nc2-c2ccc(Cl)cc2)cc1 CHEMBL2426387 IC50 571.0 nM
Cc1cc(C)c(CNc2nc(N[C@@H](C)[C@@H](C)O)nc3c2ncn3C(C)C)cn1 CHEMBL4579344 IC50 578.0 nM
COc1ccc(NC(=S)NC(=O)c2cn(-c3ccccc3)nc2-c2ccc(C)cc2)cc1 CHEMBL2426383 IC50 584.0 nM
COC[C@@H](C)N[C@H]1CC[C@H](Nc2cc(-c3cccc(NCC4(C#N)CCOCC4)n3)c(Cl)cn2)CC1 CHEMBL3656841 IC50 584.0 nM
COc1cccc(/C=C/c2n[nH]c3cc(-c4ccncc4)ccc23)c1 CHEMBL3927122 Ki 593.0 nM
C[C@@]1(O)CCC[C@H]1n1c(=O)c(C(F)F)cc2cnc(NC3CCN(S(C)(=O)=O)CC3)nc21 CHEMBL4446357 EC50 597.0 nM
O=C1Cc2c([nH]c3ccc(Cl)cc23)-c2ccccc2N1 CHEMBL98153 IC50 600.0 nM
CC(C)n1cnc2c(NCc3ccccc3)nc(C#CC(C)(O)c3ccccc3)nc21 CHEMBL336351 IC50 600.0 nM
CN1CCC(c2c(O)cc(O)c3c2O/C(=C\c2ccccc2Cl)C3=O)CC1 CHEMBL48614 IC50 600.0 nM
CCn1cnc2c(Nc3cccc(F)c3)nc(NCCN)nc21 CHEMBL439841 IC50 600.0 nM
CCn1cnc2c(Nc3cccc(F)c3)nc(NCCN)nc21 CHEMBL537838 IC50 600.0 nM
Cc1cc(-c2cnc(Nc3cnc(CN4CCN(C)CC4)cn3)s2)nc(OC2CCCCC2)n1 CHEMBL210540 IC50 600.0 nM
COC(=O)[C@@]1(Cc2ccc(O)c(CC=C(C)C)c2)OC(=O)C(O)=C1c1ccc(O)cc1 CHEMBL1242973 IC50 600.0 nM
COc1ccc(NC(=S)NC(=O)c2cn(-c3ccccc3)nc2-c2ccccc2)cc1 CHEMBL2426399 IC50 610.0 nM
C[Si](C)(C)C1=C2c3nc4ccccc4cc3C(O)CC2CC1=O CHEMBL3651154 IC50 620.0 nM
Cc1cc(O)ccc1-n1c2cc(Cl)ccc2c(=O)c2c(N)nc(N)nc21 CHEMBL1995592 pKi 630.96 nM
O=c1cc(-c2ccncc2)nc(NC2CCCCC2)[nH]1 CHEMBL1958401 pKi 630.96 nM
CC(N)C1CCC(C(=O)Nc2ccnc3[nH]ccc23)CC1 CHEMBL2002992 pKi 630.96 nM
COc1ccc2c(NC(=O)Nc3cccc(C(F)(F)F)n3)ccnc2c1 CHEMBL1982660 pKi 630.96 nM
NC(=O)c1cn(-c2ccc(O)cc2Cl)c2cc(-c3ccncc3)ccc2c1=O CHEMBL340384 pKi 630.96 nM
Fc1cnc(Nc2ccccc2)nc1Nc1ccccc1 CHEMBL491758 pKi 630.96 nM
Cc1n[nH]c2ccc(-c3cncc(OCCN)c3)cc12 CHEMBL1967887 pKi 630.96 nM
Cc1ccc(NC(=O)Nc2ccc(NC(=O)c3csc4ncnc(N)c34)cc2)cc1 CHEMBL1972576 pKi 630.96 nM
c1ccc(Cc2cn(-c3ccc4[nH]ncc4c3)nn2)cc1 CHEMBL1682341 pKi 630.96 nM
Nc1ncnc2c1N=C(c1ccc(NC(=O)Nc3cccc(C(F)(F)F)c3)cc1)CCN2 CHEMBL260092 pKi 630.96 nM
CN(C)C(=O)c1c(-c2ccc3[nH]ncc3c2)nnn1Cc1ccccc1 CHEMBL1996111 pKi 630.96 nM
Cc1nnc(-c2cc3c(Oc4ccc(C(F)(F)F)cc4)cncc3s2)o1 CHEMBL1988153 pKi 630.96 nM
NC(=O)c1cc2c(-c3ccccc3)cncc2s1 CHEMBL1999556 pKi 630.96 nM
COc1cccc2c1Nc1cc(Nc3ccncc3)ccc1C(=O)N2 CHEMBL2006276 pKi 630.96 nM
CC(=NNC(=N)N)c1cc(NC(=O)NCCCCCCNC(=O)Nc2cc(C(C)=NNC(=N)N)cc(C(C)=NNC(=N)N)c2)cc(C(C)=NNC(=N)N)c1 CHEMBL1991728 pKi 630.96 nM
COc1cc(C=C(C#N)c2n[nH]c(N)c2C#N)ccc1O CHEMBL2002407 pKi 630.96 nM
CCC(CO)Nc1nc(NCc2ccccc2)c2ncn(C(C)C)c2n1 CHEMBL52387 IC50 650.0 nM
CC(C)n1cnc2c(NCc3ccccc3)nc(N3CCC[C@@H]3CO)nc21 CHEMBL2111872 IC50 650.0 nM
CC[C@@H](CO)Nc1nc(NCc2ccccc2)c2ncn(C(C)C)c2n1 CHEMBL133342 IC50 650.0 nM
CCc1ccc2c(c1)NC(=O)/C2=N\Nc1ccc(S(N)(=O)=O)cc1 CHEMBL271182 IC50 660.0 nM
Nc1cccc(-c2[nH]nc3ncnc(Nc4cccc(Cl)c4)c23)c1 CHEMBL332882 IC50 680.0 nM
CC(C)(N)c1ccc(-c2nc(Nc3ccc(CCO)cc3)ncc2Cl)cc1 CHEMBL233205 IC50 687.0 nM
OC[C@H]1CCCN1c1nc(NCc2ccccc2)c2ncn(C3CCCC3)c2n1 CHEMBL3085251 IC50 700.0 nM
CC(C)n1cnc2c(NCc3cccc(C(F)(F)F)c3)nc(N3CCC[C@H]3CO)nc21 CHEMBL3085231 IC50 700.0 nM
CCn1cnc2c(Nc3cccc(C(F)(F)F)c3)nc(NCCN)nc21 CHEMBL534909 IC50 700.0 nM
CCn1cnc2c(Nc3cccc(C(F)(F)F)c3)nc(NCCN)nc21 CHEMBL173237 IC50 700.0 nM
CNCc1cc2cnc(Nc3cc(C(=O)N4CCN(C)CC4)n(C)c3)nc2n1C1CCCC1 CHEMBL2029904 IC50 700.0 nM
COc1cc(Nc2nccc(-c3sc(C)nc3C)n2)cc(OC)c1OC CHEMBL1083151 Ki 706.0 nM
NS(=O)(=O)c1ccc(N/N=C2\C(=O)Nc3ccc([N+](=O)[O-])cc32)cc1 CHEMBL411886 IC50 710.0 nM
NS(=O)(=O)c1ccc(N/C=C2\C(=O)Nc3cc(CO)ccc32)cc1 CHEMBL410293 IC50 740.0 nM
CS(=O)(=O)c1ccc(Nc2ncc(C(F)(F)F)c(OCCC(F)(F)F)n2)cc1 CHEMBL3644029 IC50 740.0 nM
O=C(c1ccc(-c2ccnc3[nH]c(-c4ccc(CN5CCOCC5)cc4)nc23)cc1)N1CCCC1 CHEMBL5201044 IC50 760.0 nM
Cc1nc(C)c(-c2ccnc(Nc3ccc(N)cc3)n2)s1 CHEMBL1084454 Ki 769.0 nM
NC1CCC(Nc2nc(NCc3ccc(-c4ccccc4O)cc3)c3ncn(C4CCCC4)c3n2)CC1 CHEMBL2402945 IC50 777.0 nM
CC(O)CNc1nc(NCc2ccc(-c3ccccn3)cc2)c2[nH]nc(C(C)C)c2n1 CHEMBL3774632 IC50 777.0 nM
NS(=O)(=O)c1ccc(N/N=C2\C(=O)Nc3ccc(Br)cc32)cc1 CHEMBL411491 IC50 780.0 nM
CN(C)CCc1ccc(Nc2ncc(Cl)c(-c3n[nH]c4ccccc34)n2)cc1 CHEMBL233213 IC50 781.0 nM
CC(C)c1ccc2c(c1)NC(=O)/C2=N/Nc1ccc(S(N)(=O)=O)cc1 CHEMBL271594 IC50 790.0 nM
Nc1nc(NCCN2CCOCC2)cc(-c2cc(N3C[C@H](O)[C@@H](O)C3)ccc2O)n1 CHEMBL1800463 IC50 790.0 nM
NS(=O)(=O)c1ccc(Nc2cc(-c3cccc(NC(=O)Nc4cc(C(F)(F)F)ccc4F)c3)[nH]n2)cc1 CHEMBL321939 IC50 794.0 nM
CC(=O)Nc1c(C(N)=O)sc2ccc(Cl)c(Cl)c12 CHEMBL1973142 pKi 794.33 nM
O=C1NC(=O)C(c2cnc3ccccn23)=C1c1cn2c3c(cc(F)cc13)CN(C(=O)N1CCCCC1)CC2 CHEMBL362558 pKi 794.33 nM
COc1ccc(C(=O)N2c3ccccc3Sc3c(Cl)cncc32)cc1 CHEMBL1988537 pKi 794.33 nM
CNC(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCOCC3)cc2OC)ncc1Cl CHEMBL458997 pKi 794.33 nM
Nc1n[nH]c2nnc(-c3ccccc3)c(-c3ccccc3)c12 CHEMBL260135 pKi 794.33 nM
COc1cccc(C(C)NC(=O)c2cc(C)c(-c3ccc4[nH]nc(C)c4c3)s2)c1 CHEMBL1997534 pKi 794.33 nM
Cc1cnc(Nc2cccc(S(N)(=O)=O)c2)nc1Nc1ccc(OCC(N)=O)cc1 CHEMBL1988838 pKi 794.33 nM
CS(=O)(=O)c1ccc(-c2cncc3sc(C(N)=O)cc23)cc1 CHEMBL1972362 pKi 794.33 nM
COc1cccc(C(C)NC(=O)N2CC=C(c3c[nH]c4ncccc34)CC2)c1 CHEMBL1965845 pKi 794.33 nM
O=C1Nc2ccccc2Nc2nnc(Cl)cc21 CHEMBL1968850 pKi 794.33 nM
CN(C)CCCC(=O)Nc1n[nH]c2nnc(-c3cccc(F)c3F)cc12 CHEMBL41783 pKi 794.33 nM
COc1cc(C=C(C#N)c2nc3cc(C)ccc3[nH]2)c(Br)cc1O CHEMBL2000345 pKi 794.33 nM
COc1cccc(C(C)NC(=O)c2ccc(-c3ccncc3F)cc2OC)c1 CHEMBL1991188 pKi 794.33 nM
COc1cc2c(cc1F)C(c1ccccc1Cl)=Nc1c(n[nH]c1C)N2 CHEMBL1980391 pKi 794.33 nM
CC(C)n1cnc2c(NCc3ccc(C(F)(F)F)cc3)nc(N3CCC[C@@H]3CO)nc21 CHEMBL3085233 IC50 800.0 nM
CC(C)n1cnc2c(NC(CO)c3ccccc3)nc(N3CCC[C@H]3CO)nc21 CHEMBL2112679 IC50 800.0 nM
CN1CCC(c2c(O)cc(O)c3c2O/C(=C\c2ccc(N4CCN(C)CC4)cc2)C3=O)CC1 CHEMBL46181 IC50 800.0 nM
Nc1nc(Nc2cccc(Br)c2)nc(OCC2CCCCC2)c1N=O CHEMBL107530 IC50 800.0 nM
CCN1CCN(Cc2ccc(Nc3cc(-c4cc(F)c5nc(C)n(C(C)C)c5c4)ccn3)nn2)CC1 CHEMBL4205366 IC50 800.9 nM
CC(C)(N)c1ccc(-c2nc(Nc3ccc(CCN4CCCC4)cc3)ncc2Cl)cc1 CHEMBL233208 IC50 808.0 nM
CCN(CCO)CCCNc1ccnc2cc(Cl)ccc12 CHEMBL1243003 IC50 830.0 nM
CN(C)CCc1ccc(Nc2ncc(Cl)c(-c3ccc4[nH]ccc4c3)n2)cc1 CHEMBL234624 IC50 847.0 nM
CC(C)n1cnc2c(NCc3ccccc3)nc(N[C@H](C)CO)nc21 CHEMBL2112678 IC50 850.0 nM
COc1ccc(CNc2nc(I)nc3c2ncn3C(C)C)cc1 CHEMBL130175 IC50 850.0 nM
CNc1nc(C)c(-c2ccnc(Nc3ccc(N4CCN(C(C)=O)CC4)cc3)n2)s1 CHEMBL1083785 Ki 851.0 nM
N[C@H](COc1cnc(Cl)c(-c2ccc3cnccc3c2)c1)Cc1c[nH]c2ccccc12 CHEMBL378963 IC50 870.0 nM
COc1ccc2[nH]c3c(c2c1)CC(=O)Nc1ccccc1-3 CHEMBL95827 IC50 900.0 nM
CC(O)CNc1nc(NCc2ccccc2)c2ncn(C(C)C)c2n1 CHEMBL130280 IC50 900.0 nM
CCCC(CO)Nc1nc(NCc2ccccc2)c2ncn(C(C)C)c2n1 CHEMBL131697 IC50 900.0 nM
Cc1cccc(/C=C/c2n[nH]c3cc(-c4ccncc4)ccc23)c1 CHEMBL3970483 Ki 900.0 nM
CNc1ccc(Nc2nccc(-c3sc(C)nc3C)n2)cc1 CHEMBL1083150 Ki 909.0 nM
CC(=O)NS(=O)(=O)c1ccc(N/C=C2\C(=O)Nc3ccc4ncsc4c32)cc1 CHEMBL1964243 IC50 910.0 nM
COC(=O)c1cc(NC(C)=O)ccc1S(=O)(=O)c1ccc(NC(C)=O)cc1C(=O)OC CHEMBL1243004 IC50 910.0 nM
CN1CCN(C(=O)c2cc(CNc3ncnc4ccc(C#N)cc34)ccc2Cl)CC1 CHEMBL4851465 EC50 920.0 nM
N#Cc1ccc2ncnc(NCCc3ccc4cc(C(=O)N5CCOCC5)ccc4c3)c2c1 CHEMBL4878874 EC50 930.0 nM
OCCCNc1cncc(-c2ncnc(Nc3cccc(Cl)c3)n2)n1 CHEMBL193029 IC50 971.0 nM