O=C(Nc1cccc2c1C(=O)c1c(-c3ccc(C(=O)N4CCNCC4)s3)n[nH]c1-2)NN1CCOCC1 CHEMBL334285 IC50 0.007 nM
NC(=O)Nc1cccc2c1C(=O)c1c(-c3csc(Cl)c3)n[nH]c1-2 CHEMBL151546 IC50 0.026 nM
COc1ccc(-c2[nH]nc3c2C(=O)c2c(NC(=O)CN4CCN(C(=N)N)CC4)cccc2-3)cc1 CHEMBL148580 IC50 0.08 nM
c1cc2c3cnc(Nc4cnc(N5CCNCC5)nc4)nc3n(C3CCCC3)c2cn1 CHEMBL3698644 IC50 0.13 nM
C[C@@]1(O)CCC[C@H]1n1c(=O)c(C(F)F)cc2cnc(NC3CCN(S(C)(=O)=O)CC3)nc21 CHEMBL4446357 Ki 0.13 nM
COc1ccc(-c2n[nH]c3c2C(=O)c2c(C=O)cccc2-3)cc1 CHEMBL4453997 IC50 0.2 nM
O=[N+]([O-])c1cccc(Nc2nccc(-c3cnn4ncccc34)n2)c1 CHEMBL526110 IC50 0.3 nM
c1ccc(-n2c3cnccc3c3cnc(Nc4ccc(N5CCNCC5)cc4)nc32)cc1 CHEMBL3698653 IC50 0.32 nM
c1cc2c3cnc(Nc4ccc(N5CCNCC5)cc4)nc3n(C3CCCC3)c2cn1 CHEMBL3698639 IC50 0.45 nM
CC1(C)CCc2nc3c(F)cc(-c4nc(Nc5ccc(CN6CCNCC6)cn5)ncc4F)cc3n21 CHEMBL4209329 IC50 0.6 nM
CC(C)N1CCN(Cc2ccc(Nc3ncc(F)c(-c4cc(F)c5nc6n(c5c4)C(C)CC6)n3)nc2)CC1 CHEMBL4211828 IC50 0.6 nM
COc1ccc(F)c(F)c1C(=O)c1cnc(NC2CCN(S(C)(=O)=O)CC2)nc1N CHEMBL384304 Kd 0.61 nM
CN1CCN(Cc2ccc(Nc3ncc(F)c(-c4cc(F)c5nc6n(c5c4)C(C)(C)CC6)n3)nc2)CC1 CHEMBL4215702 IC50 0.8 nM
c1cnc2c(c1)c1cnc(Nc3ccc(N4CCNCC4)cc3)nc1n2C1CCCC1 CHEMBL3698671 IC50 0.83 nM
Cc1cc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)cnc1N1CCNCC1 CHEMBL3698641 IC50 0.91 nM
c1cc2c3cnc(Nc4ccc(N5CCNCC5)cn4)nc3n(C3CC4CCC3C4)c2cn1 CHEMBL3698659 IC50 0.94 nM
CN(C)C1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)cn2)CC1 CHEMBL3698688 IC50 0.97 nM
CN(C)[C@@H]1CN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)CC[C@H]1O CHEMBL3642037 IC50 1.0 nM
CN(C)C1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)CC1 CHEMBL3698649 IC50 1.0 nM
O=C(O)CN1CCN(Cc2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CC1 CHEMBL3702122 IC50 1.0 nM
CN(C)C1CCN(c2ccc(Nc3ncc4c5ccnc(Cl)c5n(C5CCCC5)c4n3)nc2)CC1 CHEMBL3702060 IC50 1.0 nM
CCN(CC)C1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)CC1 CHEMBL3702053 IC50 1.0 nM
c1ccc2c(c1)c1cnc(Nc3ccc(N4CCNCC4)cc3)nc1n2C1CCCCC1 CHEMBL3698657 IC50 1.0 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(C(=O)N4CC5CC4CN5)cn3)nc2n1C1CCCCCC1 CHEMBL3691546 IC50 1.0 nM
CCN1CCN(Cc2ccc(Nc3nccc(-c4cc(F)c5nc6n(c5c4)C(C)(C)CC6)n3)nc2)CC1 CHEMBL4205645 IC50 1.0 nM
CCc1cnn2c(NCc3ccc[n+]([O-])c3)cc(N3CCCC[C@H]3CCO)nc12 CHEMBL2103840 IC50 1.0 nM
CC(C)N1CCN(c2ccc(Nc3ncc4cc5n(c4n3)C3(CCCCC3)CNC5=O)nc2)CC1 CHEMBL3904602 IC50 1.0 nM
CC1CCC(n2c3cnccc3c3cnc(Nc4ccc(N5CCNCC5)cn4)nc32)CC1 CHEMBL3237702 IC50 1.2 nM
CC(C)N1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CC1 CHEMBL3702046 IC50 1.2 nM
Cc1nc2ccc(-c3nc(Nc4ccc(NC(=O)CCCCCC(=O)NO)cc4)ncc3F)cc2n1C(C)C CHEMBL4866341 IC50 1.2 nM
Cc1nc2c(F)cc(-c3nc(Nc4ccc(CNC(=O)CCCCCCC(=O)NO)cc4)ncc3F)cc2n1C(C)C CHEMBL5190225 IC50 1.2 nM
Cc1nc2c(F)cc(-c3nc(Nc4ccc(CNC(=O)CC(=O)NO)cc4)ncc3F)cc2n1C(C)C CHEMBL5220945 IC50 1.2 nM
NCC1CCCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)C1 CHEMBL3698698 IC50 1.3 nM
c1ccc2c(c1)c1cnc(Nc3ccc(N4CCNCC4)cn3)nc1n2C1CCCCC1 CHEMBL3698658 IC50 1.3 nM
C1=C(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CCNC1 CHEMBL3702158 IC50 1.3 nM
OC[C@H](O)CNC1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)CC1 CHEMBL3642002 IC50 1.3 nM
O=C(O)CN1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)CC1 CHEMBL3702120 IC50 1.39 nM
O=C(c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nc1)N1CCNCC1 CHEMBL3702123 IC50 1.4 nM
c1cc2c3cnc(Nc4ccc(N5CCNCC5)nc4)nc3n(C3CCCC3)c2cn1 CHEMBL3698643 IC50 1.4 nM
OCCCNc1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nn1 CHEMBL3702197 IC50 1.4 nM
CNC1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CC1 CHEMBL3698706 IC50 1.4 nM
c1cc2c3cnc(Nc4ccc(N5CCNCC5)nn4)nc3n(C3CCCC3)c2cn1 CHEMBL3698642 IC50 1.5 nM
C[C@@H](CO)NC1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)CC1 CHEMBL3641998 IC50 1.5 nM
CCN1CCN(Cc2cnc(Nc3cc(-c4cc(F)c5nc(C)n(C(C)C)c5c4)ncn3)cn2)CC1 CHEMBL4208504 IC50 1.5 nM
c1cc2c3cnc(Nc4ccc(N5CCCNCC5)cn4)nc3n(C3CCCC3)c2cn1 CHEMBL3698683 IC50 1.6 nM
c1cc2c3cnc(Nc4ccc(N5CCNCC5)cn4)nc3n(C34CC5CC(CC(C5)C3)C4)c2cn1 CHEMBL3698661 IC50 1.6 nM
NC1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)CC1 CHEMBL3698744 IC50 1.6 nM
O[C@@H]1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)C1 CHEMBL3698654 IC50 1.6 nM
CCN1CCN(Cc2cnc(Nc3cc(-c4cc(F)c5nc(C)n(C(C)C)c5c4)c(F)cn3)cn2)CC1 CHEMBL4218267 IC50 1.6 nM
Cc1nc2c(F)cc(-c3cc(Nc4cnc(CN5CCN(C(C)C)CC5)cn4)ncn3)cc2n1C(C)C CHEMBL4202432 IC50 1.6 nM
C[C@@H](O)CNC1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)CC1 CHEMBL3641997 IC50 1.7 nM
COC(=O)CNC1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)CC1 CHEMBL3642031 IC50 1.7 nM
C[C@@H]1CN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CCN1 CHEMBL3698692 IC50 1.7 nM
CCN1CCN(Cc2ccc(Nc3ncc(F)c(-c4cc(F)c5nc(C)n(C(C)C)c5c4)n3)nc2)CC1 CHEMBL3301610 IC50 1.7 nM
CCN1CCN(Cc2ccc(Nc3ncc(F)c(-c4ccc5nc6n(c5c4)C(C)(C)CC6)n3)nc2)CC1 CHEMBL4210028 IC50 1.72 nM
COCCN1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CC1 CHEMBL3702050 IC50 1.8 nM
CC1(C)CCC(n2c3nc(Nc4ccc(N5CCNCC5)cn4)ncc3c3ccnc(O)c32)CC1 CHEMBL3702110 IC50 1.8 nM
C[C@H](CO)NC1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)CC1 CHEMBL3642000 IC50 1.9 nM
O[C@@H]1CCN(c2ccc(Nc3ncc4c5ccnc(F)c5n(C5CCCC5)c4n3)nc2)C1 CHEMBL3702091 IC50 1.9 nM
N[C@@H]1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)C1 CHEMBL3698739 IC50 1.9 nM
O=C(Nc1ccccn1)Nc1cccc2c1[C@H]1CCCN1C2=O CHEMBL141247 IC50 2.0 nM
O=c1c(Br)cc2cnc(Nc3ccc(N4CCNCC4)cc3)nc2n1C1CCCC1 CHEMBL190281 IC50 2.0 nM
CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCNCC4)cc3)nc2n(C2CCCC2)c1=O CHEMBL365847 IC50 2.0 nM
c1ccc2c(c1)c1cnc(Nc3ccc(N4CCNCC4)cc3)nc1n2C1CCCC1 CHEMBL3698682 IC50 2.0 nM
Clc1nccc2c3cnc(Nc4ccc(N5CCNCC5)cn4)nc3n(C3CCCC3)c12 CHEMBL3237444 IC50 2.0 nM
CC[C@H](C)n1c2cnccc2c2cnc(Nc3ccc(N4CC[C@@H](O)C4)cn3)nc21 CHEMBL3702236 IC50 2.0 nM
NC1CCCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)C1 CHEMBL3698746 IC50 2.0 nM
O=C(O)CNC1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CC1 CHEMBL3642032 IC50 2.0 nM
C[C@@H]1CNCCN1c1ccc(Nc2ncc3c4ccnc(F)c4n(C4CCCC4)c3n2)nc1 CHEMBL3702085 IC50 2.0 nM
c1ccc2c(c1)c1cnc(Nc3ccc(N4CCNCC4)cc3)nc1n2C1CCOCC1 CHEMBL3698681 IC50 2.0 nM
O=C(O)CNC1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)CC1 CHEMBL3642033 IC50 2.0 nM
O[C@H]1CCN(c2ccc(Nc3ncc4c5ccnc(F)c5n(C5CCCC5)c4n3)nc2)C1 CHEMBL3702092 IC50 2.0 nM
CN(C)C1CCN(c2ccc(Nc3ncc4c5ccnc(F)c5n(C5CCCC5)c4n3)nn2)CC1 CHEMBL3702154 IC50 2.0 nM
Fc1nccc2c3cnc(Nc4ccc(N5CCNCC5)cn4)nc3n(C3CCCC3)c12 CHEMBL3237443 IC50 2.0 nM
NC1CCN(c2ccc(Nc3ncc4c5cc[nH]c(=O)c5n(C5CCCC5)c4n3)nn2)CC1 CHEMBL3702034 IC50 2.0 nM
C[C@H]1CN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CCN1 CHEMBL3698693 IC50 2.0 nM
CCNC1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CC1 CHEMBL3642019 IC50 2.0 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(N4CCNCC4)cn3)nc2n1C1CCCC1 CHEMBL3545110 IC50 2.0 nM
CNc1nc(C)c(-c2nc(Nc3ccc(N4CCC(N(C)C)CC4)cn3)ncc2F)s1 CHEMBL5287062 Ki 2.0 nM
c1ccc2c(c1)c1cnc(Nc3ccc(N4CCNCC4)cn3)nc1n2C1CCOCC1 CHEMBL3698673 IC50 2.1 nM
c1ccc2c(c1)c1cnc(Nc3ccc(N4CCNCC4)cn3)nc1n2C1CCCCCC1 CHEMBL3698674 IC50 2.1 nM
C[C@H]1CC[C@H](n2c3cnccc3c3cnc(Nc4ccc5c(n4)CCNC5)nc32)CC1 CHEMBL3680379 IC50 2.1 nM
CCN1CCN(Cc2cnc(Nc3cc(-c4cc(F)c5nc(C)n(C(C)C)c5c4)ccn3)cn2)CC1 CHEMBL4204030 IC50 2.1 nM
OCC(CO)NC1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)CC1 CHEMBL3642001 IC50 2.2 nM
c1cc2c3cnc(Nc4ccc(CN5CCOCC5)cn4)nc3n(C3CCCC3)c2cn1 CHEMBL3702049 IC50 2.2 nM
CC1(C)CN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)CCN1 CHEMBL3698646 IC50 2.2 nM
c1ccc(-n2c3cnccc3c3cnc(Nc4ccc(N5CCNCC5)cn4)nc32)cc1 CHEMBL3698650 IC50 2.2 nM
O=S1(=O)CC=C(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CC1 CHEMBL3702167 IC50 2.2 nM
Cc1nc2c(F)cc(-c3cc(Nc4cnc(CN5CCN(C6CCCC6)CC5)cn4)ncn3)cc2n1C(C)C CHEMBL4216534 IC50 2.2 nM
O=C(Nc1cc(CN[C@H]2Cc3ccc(Cl)cc3C2)n[nH]1)Nc1cccc2c1[C@@H]1CCCN1C2=O CHEMBL336242 IC50 2.3 nM
CC1CN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CC(C)N1 CHEMBL3698703 IC50 2.3 nM
O=C1CN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)CCN1 CHEMBL3698745 IC50 2.3 nM
OC[C@H]1CN(c2ccc(Nc3ncc4c5ccnc(F)c5n(C5CCCC5)c4n3)nc2)CCN1 CHEMBL3702101 IC50 2.4 nM
C[C@H]1CC[C@H](n2c3cnccc3c3cnc(Nc4ccc5c(n4)CCN(C(=O)CO)C5)nc32)CC1 CHEMBL3237719 IC50 2.4 nM
CS(=O)(=O)CCN1CCc2nc(Nc3ncc4c5ccncc5n([C@H]5CC[C@H](C)CC5)c4n3)ccc2C1 CHEMBL3680385 IC50 2.4 nM
CCN1CCC(Cc2cnc(Nc3cc(-c4cc(F)c5nc(C)n(C(C)C)c5c4)ncn3)cn2)CC1 CHEMBL4207218 IC50 2.4 nM
OCCN1CCN(c2ccc(Nc3ncc4c5ccnc(F)c5n(C5CCCC5)c4n3)nc2)CC1 CHEMBL3702077 IC50 2.5 nM
c1cc2c3cnc(Nc4ccc(NCC5CCNC5)nn4)nc3n(C3CCCC3)c2cn1 CHEMBL3698728 IC50 2.5 nM
OC1CCC(n2c3cnccc3c3cnc(Nc4ccc(N5CCNCC5)cn4)nc32)CC1 CHEMBL3971812 IC50 2.5 nM
O=C(c1csc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)n1)N1CCNCC1 CHEMBL3698684 IC50 2.5 nM
CC(C)n1c2cnccc2c2cnc(Nc3ccc(N4CCC(N(C)C)CC4)nn3)nc21 CHEMBL3702067 IC50 2.5 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(-c4csc5c(=O)cc(N6CCOCC6)oc45)cc3)nc2n1C1CCCC1 CHEMBL5190816 IC50 2.5 nM
CN(C)C1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCC(C)(C)CC5)c4n3)cn2)CC1 CHEMBL3702107 IC50 2.6 nM
NC1CCN(c2cnc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)cn2)CC1 CHEMBL3698713 IC50 2.6 nM
C[C@@H](CO)NC1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CC1 CHEMBL3642030 IC50 2.6 nM
CCN(CC)C1CCN(c2ccc(Nc3ncc4c5ccnc(OC)c5n(C5CCCC5)c4n3)nc2)CC1 CHEMBL3702186 IC50 2.6 nM
C[C@H](O)Cn1c2cnccc2c2cnc(Nc3ccc(N4CC[C@@H](O)C4)nn3)nc21 CHEMBL3641972 IC50 2.6 nM
C[C@H]1CC[C@H](n2c3cnccc3c3cnc(Nc4ccc5c(n4)CCN(CCO)C5)nc32)CC1 CHEMBL3680381 IC50 2.6 nM
N#Cc1ccc2c3cnc(Nc4ccc(N5CCNCC5)cn4)nc3n(C3CCCC3)c2c1 CHEMBL3698676 IC50 2.7 nM
c1cc2c3cnc(Nc4ccc(N5CCC(N6CCOCC6)CC5)nn4)nc3n(C3CCCC3)c2cn1 CHEMBL3642003 IC50 2.8 nM
c1cc2c3cnc(Nc4ccc(N[C@H]5CCNC5)cn4)nc3n(C3CCCC3)c2cn1 CHEMBL3698695 IC50 2.8 nM
CCN(CC)C1CCN(c2ccc(Nc3ncc4c5ccnc(O)c5n(C5CCCC5)c4n3)nn2)CC1 CHEMBL3702183 IC50 2.8 nM
CC[C@@H](C)n1c2cnccc2c2cnc(Nc3ccc(N4CCC(NC)CC4)nn3)nc21 CHEMBL3702218 IC50 2.9 nM
OCC1CCN(c2ccc(Nc3ncc4c5ccnc(F)c5n(C5CCCC5)c4n3)nc2)CC1 CHEMBL3702093 IC50 2.9 nM
CCN1CCN(Cc2ccc(Nc3cc(-c4cc(F)c5nc(C)n(C(C)C)c5c4)ccn3)nc2)CC1 CHEMBL4208198 IC50 2.9 nM
Cc1nc2c(F)cc(-c3cc(Nc4cnc(CN5CCN(CC6CC6)CC5)cn4)ncn3)cc2n1C(C)C CHEMBL4213557 IC50 2.9 nM
CC(C)n1c2cnccc2c2cnc(Nc3ccc(N4CCNCC4)cn3)nc21 CHEMBL3702066 IC50 3.0 nM
CNC1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)CC1 CHEMBL3698708 IC50 3.0 nM
O=S(=O)(c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nc1)N1CCNCC1 CHEMBL3702129 IC50 3.0 nM
O=C(CO)N1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CC1 CHEMBL3702059 IC50 3.0 nM
CCN(CC)CC(=O)N1CCc2nc(Nc3ncc4c5ccncc5n([C@H]5CC[C@H](C)CC5)c4n3)ccc2C1 CHEMBL3684993 IC50 3.0 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(C(=O)N4CC5CCC(C4)N5)cn3)nc2n1[C@@H]1C[C@H]2CC[C@@H]1C2 CHEMBL3691579 IC50 3.0 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(C(=O)N4CC5CCC(C4)N5)cn3)nc2n1-c1ccc(C(C)(C)C)cc1 CHEMBL3691595 IC50 3.0 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(C(=O)N4CC5CCC(C4)N5)cn3)nc2n1-c1cccc(C(C)(C)C)c1 CHEMBL3691596 IC50 3.0 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(C(=O)N4CC5CC4CN5)cn3)nc2n1C1CCCCC1 CHEMBL3691608 IC50 3.0 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(N4C[C@H]5CNC[C@H]5C4=O)cn3)nc2n1C1CCCCCC1 CHEMBL3691620 IC50 3.0 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(N4C[C@@H]5CNC[C@@H]5CC4=O)cn3)nc2n1C1CCCCCC1 CHEMBL3691626 IC50 3.0 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(N4C[C@H]5CC[C@@H](CC4=O)N5)cn3)nc2n1C1CCCC1 CHEMBL3691660 IC50 3.0 nM
C[C@H]1CC[C@@H](n2c3cnccc3c3cnc(Nc4ccc5c(n4)CCN(C(=O)CO)C5)nc32)CC1 CHEMBL5207533 IC50 3.0 nM
OC1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)CC1 CHEMBL3698732 IC50 3.1 nM
NC1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CC1 CHEMBL3698647 IC50 3.1 nM
Oc1ccc(-c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)cn1 CHEMBL3702168 IC50 3.1 nM
O=S1(=O)CCC(Nc2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)C1 CHEMBL3698723 IC50 3.1 nM
CCN1CCN(Cc2ccc(Nc3cc(-c4cc(F)c5nc(C)n(C(C)C)c5c4)ncn3)nc2)CC1 CHEMBL4214898 IC50 3.1 nM
c1cc2c3cnc(Nc4ccc(N5CCNCC5)cn4)nc3n(C3CCCC3)c2cn1 CHEMBL3237442 IC50 3.2 nM
CN1CCOC2(CCN(c3ccc(Nc4ncc5c6ccncc6n(C6CCCC6)c5n4)nn3)CC2)C1 CHEMBL3702153 IC50 3.2 nM
O=C1CNCCN1Cc1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nc1 CHEMBL3702128 IC50 3.2 nM
CN1CC[C@H](c2c(O)cc(O)c3c(=O)cc(-c4ccccc4Cl)oc23)[C@H](O)C1 CHEMBL428690 Kd 3.3 nM
c1cc2c3cnc(Nc4ccc(N5CCC6(CCCN6)CC5)cn4)nc3n(C3CCCC3)c2cn1 CHEMBL3702133 IC50 3.3 nM
O[C@@H]1CCCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)C1 CHEMBL3698734 IC50 3.3 nM
C[C@H]1CN(c2ccc(Nc3ncc4c5ccnc(F)c5n(C5CCCC5)c4n3)nc2)CCN1 CHEMBL3702084 IC50 3.4 nM
c1cc2c3cnc(Nc4ccc(N[C@@H]5CCNC5)cn4)nc3n(C3CCCC3)c2cn1 CHEMBL3698694 IC50 3.4 nM
c1cc2c3cnc(Nc4ccc(N5CCNC6(CCCC6)C5)nn4)nc3n(C3CCCC3)c2cn1 CHEMBL3702149 IC50 3.4 nM
CCN(CC)C1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CC1 CHEMBL3702052 IC50 3.4 nM
COC1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)C1 CHEMBL3698740 IC50 3.4 nM
CC1(C)CCC(n2c3cnccc3c3cnc(Nc4ccc(N5CCNCC5)cn4)nc32)CC1 CHEMBL3237704 IC50 3.5 nM
C[C@@H]1CN(c2cnc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)cn2)CCN1 CHEMBL3698711 IC50 3.5 nM
O=c1c2cccc3c2sn1CCCCCOc1cccc2nc(O)c-3nc12 CHEMBL386796 IC50 3.6 nM
CC[C@@H](C)n1c2cnccc2c2cnc(Nc3ccc(N4CCNCC4)cn3)nc21 CHEMBL3702220 IC50 3.6 nM
c1cc2c3cnc(Nc4ccc(NCC5CCNC5)cn4)nc3n(C3CCCC3)c2cn1 CHEMBL3698701 IC50 3.6 nM
CCC(CC)n1c2cnccc2c2cnc(Nc3ccc(N4CCNCC4)cn3)nc21 CHEMBL3702068 IC50 3.6 nM
c1cc2c3cnc(Nc4nc(CN5CCNCC5)cs4)nc3n(C3CCCC3)c2cn1 CHEMBL3702071 IC50 3.6 nM
CCOC(=O)CN1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)CC1 CHEMBL3702119 IC50 3.6 nM
C[C@H](O)CNC1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)CC1 CHEMBL3641995 IC50 3.7 nM
COCCN1CCN(Cc2cnc(Nc3cc(-c4cc(F)c5nc(C)n(C(C)C)c5c4)ncn3)cn2)CC1 CHEMBL4214634 IC50 3.7 nM
COCCN1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)CC1 CHEMBL3702051 IC50 3.8 nM
C[C@H]1CN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)CCN1 CHEMBL3698645 IC50 3.8 nM
CN(CCO)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nn1 CHEMBL3702191 IC50 3.9 nM
C[C@@H]1CN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)CCN1 CHEMBL3698640 IC50 3.9 nM
C[C@@H]1CN(c2ccc(Nc3ncc4c5ccnc(F)c5n(C5CCCC5)c4n3)nn2)CCN1 CHEMBL3702155 IC50 3.9 nM
C[C@@H](C1CCCCC1)n1c2cnccc2c2cnc(Nc3ccc(N4CCNCC4)cn3)nc21 CHEMBL3698664 IC50 3.9 nM
CN1CCN(c2ccc(Nc3ncc4cc(C#N)c(=O)n(C5CCCC5)c4n3)cc2)CC1 CHEMBL3115681 IC5 3.9 nM
N#Cc1cccc(Nc2nccc(-c3cnn4ncccc34)n2)c1 CHEMBL495696 IC50 4.0 nM
NCC1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)CC1 CHEMBL3698731 IC50 4.0 nM
NCC1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CC1 CHEMBL3698691 IC50 4.0 nM
c1cc2c3cnc(Nc4ccc(N5CCOCC5)nn4)nc3n(C3CCCC3)c2cn1 CHEMBL3698736 IC50 4.0 nM
O[C@H]1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)C1 CHEMBL3698655 IC50 4.0 nM
O=C1CN(Cc2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CCN1 CHEMBL3702127 IC50 4.0 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(C(=O)N4CC5CCC(C4)N5)cn3)nc2n1C1CCCCCC1 CHEMBL3691547 IC50 4.0 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(N4C[C@@H]5CNC[C@@H]5C4=O)cn3)nc2n1C1CCCCCC1 CHEMBL3691621 IC50 4.0 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(N4CC5CCC(CC4=O)N5)cn3)nc2n1C1CCCCC1 CHEMBL3691667 IC50 4.0 nM
CC(C)[C@H](CO)Nc1nc(Nc2cccc(Cl)c2)c2ncn(C(C)C)c2n1 CHEMBL23327 IC50 4.0 nM
COCCN1CCN(Cc2ccc(-c3n[nH]c4c3C(=O)c3c(NC(=O)NN5CCOCC5)cccc3-4)cc2)CC1 CHEMBL3545083 IC50 4.0 nM
c1cc2c3cnc(Nc4ccc(N5CCC(NC6CC6)CC5)cn4)nc3n(C3CCCC3)c2cn1 CHEMBL3642020 IC50 4.1 nM
CN(CC(=O)O)C1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CC1 CHEMBL3642026 IC50 4.1 nM
Cc1nc(Nc2ncc3c4ccnc(Cl)c4n(C4CCCC4)c3n2)ccc1N1CCNCC1 CHEMBL3702062 IC50 4.1 nM
CN(c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nc1)C1CCCNC1 CHEMBL3698699 IC50 4.1 nM
c1cc2c3cnc(Nc4ccc(NCC5CCCNC5)cn4)nc3n(C3CCCC3)c2cn1 CHEMBL3698702 IC50 4.1 nM
c1ccc(Nc2ncc(-c3ccnc(OC4CCCCC4)n3)s2)nc1 CHEMBL424696 IC50 4.2 nM
OCCNC1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)CC1 CHEMBL3641994 IC50 4.2 nM
OC[C@H]1CN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CCN1 CHEMBL3702102 IC50 4.2 nM
N#CC1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)C1 CHEMBL3698748 IC50 4.2 nM
c1cc2c3cnc(Nc4ccc(N5CCC(NC6CCC6)CC5)cn4)nc3n(C3CCCC3)c2cn1 CHEMBL3642023 IC50 4.2 nM
CC1CN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)CC(C)N1 CHEMBL3698743 IC50 4.2 nM
CCC1CN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)CCN1 CHEMBL3702029 IC50 4.3 nM
c1ccc2c(c1)c1cnc(Nc3ccc(N4CCNCC4)cn3)nc1n2C1CCCC1 CHEMBL3698672 IC50 4.3 nM
OCCN1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CC1 CHEMBL3702096 IC50 4.4 nM
c1cc2c3cnc(Nc4ccc(N5CCNCC5)cn4)cc3n(C3CCCCC3)c2cn1 CHEMBL3702142 IC50 4.4 nM
NCC1CCCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)C1 CHEMBL3698725 IC50 4.4 nM
OC1CCN(Cc2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CC1 CHEMBL3702117 IC50 4.4 nM
c1cc2c3cnc(Nc4ccc(N5CCCC5)nn4)nc3n(C3CCCC3)c2cn1 CHEMBL3698741 IC50 4.4 nM
c1cc2c3cnc(Nc4ccc(N5CCC6(CC5)COCCN6)nn4)nc3n(C3CCCC3)c2cn1 CHEMBL3702151 IC50 4.4 nM
CC(=O)N1Cc2ccc(Nc3ncc4c5ccncc5n([C@H]5CC[C@H](C)CC5)c4n3)nc2C(C)C1 CHEMBL3684982 IC50 4.4 nM
C[C@@H](O)CNC1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CC1 CHEMBL3642016 IC50 4.5 nM
OC[C@@H]1CN(c2ccc(Nc3ncc4c5ccnc(F)c5n(C5CCCC5)c4n3)nc2)CCN1 CHEMBL3702104 IC50 4.5 nM
CC(=O)N1CCc2nc(Nc3ncc4c5ccncc5n([C@H]5CC[C@H](C)CC5)c4n3)ccc2C1 CHEMBL3680380 IC50 4.5 nM
c1cc2c3cnc(Nc4ccc(N5CCNCC5)cn4)nc3n(C3CCC3)c2cn1 CHEMBL3698665 IC50 4.6 nM
C[C@@H](O)CNc1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nn1 CHEMBL3702193 IC50 4.6 nM
OCCCNC1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)CC1 CHEMBL3642009 IC50 4.6 nM
CCN(CC)C1CCN(c2ccc(Nc3ncc4c5ccnc(F)c5n(C5CCCC5)c4n3)nc2)CC1 CHEMBL3702179 IC50 4.6 nM
OC[C@@H]1CN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CCN1 CHEMBL3702103 IC50 4.6 nM
c1ccc(-n2c3cnccc3c3cnc(Nc4ccc(N5CCNCC5)cn4)cc32)cc1 CHEMBL3702135 IC50 4.6 nM
C[C@H]1CC[C@H](n2c3cnccc3c3cnc(Nc4ccc5c(n4)CCN(CCCO)C5)nc32)CC1 CHEMBL3680382 IC50 4.6 nM
O=c1[nH]ccc2c3cnc(Nc4ccc(N5CCNCC5)cn4)nc3n(C3CCCC3)c12 CHEMBL3237446 IC50 4.7 nM
CCCNC1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CC1 CHEMBL3642021 IC50 4.7 nM
C[C@H]1CC[C@H](n2c3cnccc3c3cnc(Nc4cc5c(cn4)CNCC5)nc32)CC1 CHEMBL3684991 IC50 4.7 nM
OCCNC1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CC1 CHEMBL3642014 IC50 4.8 nM
CNCCN(C)C1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)CC1 CHEMBL3641999 IC50 4.8 nM
O=S1(=O)CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)CC1 CHEMBL3698724 IC50 4.9 nM
c1cc2c3cnc(Nc4ccc(NCC5CCCCN5)nn4)nc3n(C3CCCC3)c2cn1 CHEMBL3698729 IC50 4.9 nM
CN(C)CCNC1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)CC1 CHEMBL3642035 IC50 4.9 nM
c1cc2c3cnc(Nc4ccc(N5CCNCC5)cc4)nc3n(C3CC4CCC3C4)c2cn1 CHEMBL3698675 IC50 4.9 nM
OCCNc1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nn1 CHEMBL3702192 IC50 4.9 nM
Cc1c(Br)c(=O)n(C2CCCC2)c2nc(Nc3ccc(N4CCNCC4)cc3)ncc12 CHEMBL189937 IC50 5.0 nM
CN(C)[C@H]1CN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)CC[C@@H]1O CHEMBL3702160 IC50 5.0 nM
CCN(CC)C1CCN(c2ccc(Nc3ncc4c5ccnc(O)c5n(C5CCCC5)c4n3)nc2)CC1 CHEMBL3702185 IC50 5.0 nM
C[C@@H]1CN(c2ccc(Nc3ncc4c5ccnc(F)c5n(C5CCCC5)c4n3)nc2)CCN1 CHEMBL3702083 IC50 5.0 nM
OC1CN(C2CCN(c3ccc(Nc4ncc5c6ccncc6n(C6CCCC6)c5n4)nc3)CC2)C1 CHEMBL3642029 IC50 5.0 nM
C[C@H]1CNCCN1c1ccc(Nc2ncc3c4ccnc(F)c4n(C4CCCC4)c3n2)nc1 CHEMBL3702082 IC50 5.0 nM
CNC1CCN(c2ccc(Nc3ncc4c5ccnc(F)c5n(C5CCCC5)c4n3)nc2)CC1 CHEMBL3702210 IC50 5.0 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(C(=O)N4C[C@H]5CNC[C@@H](C4)C5O)cn3)nc2n1C1CCCCCC1 CHEMBL3691545 IC50 5.0 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(C(=O)N4C[C@@H]5CN[C@@H](C5)C4)cn3)nc2n1C1CCCC1 CHEMBL3691553 IC50 5.0 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(N4C[C@H]5CNC[C@H]5CC4=O)cn3)nc2n1C1CCCCCC1 CHEMBL3691625 IC50 5.0 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(N4CC5CNCC5CC4=O)cn3)nc2n1C1CCCC1 CHEMBL3691627 IC50 5.0 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(N4CC5CCC(CC4=O)N5)cn3)nc2n1-c1ccc(C(C)(C)C#N)cc1 CHEMBL3691663 IC50 5.0 nM
C[C@@H](O)[C@@H](C)Oc1nc(Nc2ccc(S(=N)(=O)C3CC3)cc2)ncc1C(F)(F)F CHEMBL4442620 IC50 5.0 nM
F[C@@H]1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)C1 CHEMBL3698749 IC50 5.1 nM
Fc1cncc2c1c1cnc(Nc3ccc(N4CCNCC4)cn3)nc1n2C1CCCC1 CHEMBL3698689 IC50 5.2 nM
CCN(CCO)C1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)CC1 CHEMBL3642010 IC50 5.2 nM
CCN1CCN(Cc2ccc(Nc3cc(-c4cc(F)c5nc(C)n(C(C)C)c5c4)ccn3)nn2)CC1 CHEMBL4205366 IC50 5.2 nM
CC1(n2c3cnccc3c3cnc(Nc4ccc(N5CCNCC5)cn4)nc32)CCC1 CHEMBL3698668 IC50 5.3 nM
CCOC(=O)CN1CCN(Cc2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CC1 CHEMBL3702121 IC50 5.3 nM
CN(C)C1CCN(c2ccc(Nc3ncc4c5cc[nH]c(=O)c5n(C5CCCC5)c4n3)nn2)CC1 CHEMBL3702035 IC50 5.3 nM
CN(C)C1CC2CCC(C1)N2c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nc1 CHEMBL3702065 IC50 5.4 nM
O=S1(=O)CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CC1 CHEMBL3698697 IC50 5.4 nM
C[C@@H](CO)Nc1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nn1 CHEMBL3702196 IC50 5.5 nM
c1cc2c3cnc(Nc4ccc(N5CCCNCC5)nn4)nc3n(C3CCCC3)c2cn1 CHEMBL3698747 IC50 5.5 nM
OCCN1CCN(c2ccc(Nc3ncc4c5ccnc(Cl)c5n(C5CCCC5)c4n3)nc2)CC1 CHEMBL3702073 IC50 5.5 nM
CC(C)(C)n1c2cnccc2c2cnc(Nc3ccc(N4CCNCC4)cn3)nc21 CHEMBL3698662 IC50 5.5 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(C(=O)N4CC5CCC(C4)N5)cn3)nc2n1[C@H]1CC[C@H](C(C)(C)C)CC1 CHEMBL3691580 IC50 5.5 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(C(=O)N4CC5CCC(C4)N5)cn3)nc2n1C1CCCCC1 CHEMBL3691607 IC50 5.5 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(C(=O)N4CC[C@@H]5CC[C@H](C4)N5)cn3)nc2n1C1CCCC1 CHEMBL3691612 IC50 5.5 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(N4C[C@H]5CNC[C@H]5C4=O)cn3)nc2n1C1CCCC1 CHEMBL3691622 IC50 5.5 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(N4C[C@H]5CC[C@@H](CC4=O)N5C)cn3)nc2n1C1CCCC1 CHEMBL3691676 IC50 5.5 nM
CC(C)(O)CN1CCN(c2ccc(Nc3ncc4c5ccnc(F)c5n(C5CCCC5)c4n3)nc2)CC1 CHEMBL3702079 IC50 5.6 nM
C1=C(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)CCNC1 CHEMBL3702157 IC50 5.6 nM
N[C@@H]1CCN(c2cnc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)cn2)C1 CHEMBL3698720 IC50 5.6 nM
OCC1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)CC1 CHEMBL3698733 IC50 5.6 nM
Cc1nc2c(F)cc(-c3cc(Nc4cnc(CN5CCN(CC(F)(F)F)CC5)cn4)ncn3)cc2n1C(C)C CHEMBL4214123 IC50 5.6 nM
CC(C)NC1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CC1 CHEMBL3642024 IC50 5.7 nM
CC1(C)CCc2nc3c(F)cc(-c4nc(Nc5ccc(CN6CCN(CCF)CC6)cn5)ncc4F)cc3n21 CHEMBL4210707 IC50 5.7 nM
CC1CCc2nc3c(F)cc(-c4nc(Nc5ccc(CN6CCN(C)CC6)cn5)ncc4F)cc3n21 CHEMBL4209318 IC50 5.7 nM
CN(CCO)C1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)CC1 CHEMBL3641996 IC50 5.8 nM
C[C@H](O)CNc1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nn1 CHEMBL3702194 IC50 5.9 nM
c1cc2c3cnc(Nc4ccc(N5CCC(N6CCCC6)CC5)cn4)nc3n(C3CCCC3)c2cn1 CHEMBL3698707 IC50 5.9 nM
CN1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)CC1 CHEMBL3698742 IC50 5.9 nM
O=c1c2cccc3c2sn1CCNCCOc1cccc2nc(O)c-3nc12 CHEMBL383961 IC50 6.0 nM
O=c1c2cccc(-c3nc4ccccc4nc3O)c2sn1C1CCCC1 CHEMBL386467 IC50 6.0 nM
CN1CCN(c2ccc(Nc3nccc(-c4cnn5ncccc45)n3)cc2C(F)(F)F)CC1 CHEMBL468963 IC50 6.0 nM
O=C(c1ccc(Nc2ncc3c4ccnc(F)c4n(C4CCCC4)c3n2)nc1)N1CCNCC1 CHEMBL3702124 IC50 6.0 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(C(=O)N4CC5CC(C4)N(C)C5)cn3)nc2n1C1CCCC1 CHEMBL3691556 IC50 6.0 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(N4C[C@@H]5CNC[C@@H]5C4=O)cn3)nc2n1C1CCCC1 CHEMBL3691623 IC50 6.0 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(N4C[C@H]5CNC[C@H]5CC4=O)cn3)nc2n1C1CCCC1 CHEMBL3691628 IC50 6.0 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(N4C[C@@H]5CNC[C@@H]5CC4=O)cn3)nc2n1C1CCCC1 CHEMBL3691629 IC50 6.0 nM
c1cc2c3cnc(Nc4ccc(N[C@@H]5CCNC5)nn4)nc3n(C3CCCC3)c2cn1 CHEMBL3698721 IC50 6.1 nM
c1cc2c3cnc(Nc4ccc(NCC5COCCN5)nn4)nc3n(C3CCCC3)c2cn1 CHEMBL3698730 IC50 6.2 nM
CN(C)C1CN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)CCC1O CHEMBL3642038 IC50 6.2 nM
C[C@H]1CC[C@H](n2c3cnccc3c3cnc(Nc4ccc5c(n4)CN(C(=O)CO)CC5)nc32)CC1 CHEMBL3684992 IC50 6.3 nM
C[C@@H]1C[C@H]2CN1CCn1nc3c(cccc3c1O)-c1nc3c(cccc3nc1O)O2 CHEMBL215803 IC50 6.4 nM
c1cc2c3cnc(Nc4cnc(N5CCCNCC5)cn4)nc3n(C3CCCC3)c2cn1 CHEMBL3698716 IC50 6.4 nM
OCCC1CCN(c2ccc(Nc3ncc4c5ccnc(F)c5n(C5CCCC5)c4n3)nc2)CC1 CHEMBL3702095 IC50 6.4 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(C(=O)N4C[C@@H]5CC4CN5)cn3)nc2n1C1CCCC1 CHEMBL3691562 IC50 6.5 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(C(=O)N4CC5CCC(C4)N5)cn3)nc2n1-c1ccc(C(C)(C)C#N)cc1 CHEMBL3691609 IC50 6.5 nM
CC1(C)CCC(n2c3nc(Nc4ccc(N5CCC(N6CCCC6)CC5)cn4)ncc3c3ccnc(O)c32)CC1 CHEMBL3702112 IC50 6.6 nM
O[C@H]1CCCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)C1 CHEMBL3698735 IC50 6.7 nM
c1cc2c3cnc(Nc4ccc(N5CCNCC5)cn4)cc3n(C3CCSC3)c2cn1 CHEMBL3702141 IC50 6.8 nM
C[C@H](CO)Nc1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nn1 CHEMBL3702195 IC50 6.8 nM
CCN1CCN(Cc2ccc(Nc3ncc(F)c(-c4cc(F)c5nc6n(c5c4)CCCC6)n3)nc2)CC1 CHEMBL4208366 IC50 6.8 nM
CC1(C)CN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CCN1 CHEMBL3702044 IC50 6.9 nM
CC[C@@H](C)n1c2cnccc2c2cnc(Nc3ccc(N4CCN[C@@H](C)C4)cn3)nc21 CHEMBL3702221 IC50 7.0 nM
O[C@H]1CCCN(C2CCN(c3ccc(Nc4ncc5c6ccncc6n(C6CCCC6)c5n4)nn3)CC2)C1 CHEMBL3642008 IC50 7.0 nM
CCC(C)(C)n1c2cnccc2c2cnc(Nc3ccc(N4CCC(N(C)C)CC4)nn3)nc21 CHEMBL3702063 IC50 7.0 nM
OC1CCN(C2CCN(c3ccc(Nc4ncc5c6ccncc6n(C6CCCC6)c5n4)nn3)CC2)CC1 CHEMBL3642011 IC50 7.0 nM
c1cc2c3cnc(Nc4ccc(C5CCNCC5)cn4)nc3n(C3CCCC3)c2cn1 CHEMBL3702159 IC50 7.0 nM
CN(C)C1CCN(C(=O)Cc2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CC1 CHEMBL3702145 IC50 7.0 nM
CN1C[C@H]2CN(c3ccc(Nc4ncc5cc(C(=O)N(C)C)n(C6CCCC6)c5n4)nc3)C(=O)[C@H]2C1 CHEMBL3691632 IC50 7.0 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(N4C[C@@H]5CC[C@H](CC4=O)N5)cn3)nc2n1C1CCC1 CHEMBL3691671 IC50 7.0 nM
CN(C)[C@@H]1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)C1 CHEMBL3702189 IC50 7.2 nM
FCCNC1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CC1 CHEMBL3642022 IC50 7.2 nM
c1cc2c3cnc(Nc4ccc(N5CCC6(CCCN6)CC5)nn4)nc3n(C3CCCC3)c2cn1 CHEMBL3702134 IC50 7.2 nM
O=C(Cc1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nc1)N1CCNCC1 CHEMBL3702147 IC50 7.4 nM
CCN1CCN(Cc2ccc(Nc3ncc(F)c(-c4cc(F)c5nc6n(c5c4)C(C)(C)CC6)n3)nc2)CC1 CHEMBL4208172 IC50 7.4 nM
Fc1ccc(-n2c3cnccc3c3cnc(Nc4ccc(N5CCNCC5)cn4)nc32)cc1 CHEMBL3698651 IC50 7.5 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(N4CC5CCC(CC4=O)N5)cn3)nc2n1C1CCCC1 CHEMBL3691659 IC50 7.5 nM
N[C@H]1CCN(c2cnc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)cn2)C1 CHEMBL3698719 IC50 7.6 nM
O=[N+]([O-])c1ccc(Nc2nccc(-c3cnn4ncccc34)n2)cc1 CHEMBL188938 IC50 8.0 nM
CCN(CC)CCNC(=O)c1cccc(Nc2nccc(-c3cnn4ncccc34)n2)c1 CHEMBL495751 IC50 8.0 nM
CN(C)CCN(C)C1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)CC1 CHEMBL3642034 IC50 8.0 nM
OC[C@@H](O)CNC1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)CC1 CHEMBL3642036 IC50 8.0 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(C(=O)N4CCC[C@@H]5CCN[C@@H]5C4)cn3)nc2n1C1CCCC1 CHEMBL3691568 IC50 8.0 nM
CSCC[C@@H](N)C(=O)N1C2CCC1CN(C(=O)c1ccc(Nc3ncc4cc(C(=O)N(C)C)n(C5CCCC5)c4n3)nc1)C2 CHEMBL3691601 IC50 8.0 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(N4C[C@]5(CCCNC5)OC4=O)cn3)nc2n1C1CCCC1 CHEMBL3691647 IC50 8.0 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(N4CCN5CCCC5C4)cn3)nc2n1C1CCCC1 CHEMBL3691654 IC50 8.0 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(N4CC5CCC(CC4=O)N5)cn3)nc2n1C1CCC1 CHEMBL3691670 IC50 8.0 nM
CC(C)N1CCN(c2ccc(Nc3ncc4cc(C(=O)N(C)C)n(C5CCCC5)c4n3)nc2)CC1 CHEMBL3658050 IC50 8.0 nM
c1cc2c3cnc(Nc4ccc(N5CCNCC5)cn4)nc3n(C3CCOCC3)c2cn1 CHEMBL3698656 IC50 8.1 nM
c1cnc2c(c1)c1cnc(Nc3ccc(N4CCNCC4)cn3)nc1n2C1CCCC1 CHEMBL3698670 IC50 8.2 nM
CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCNCC4)cn3)nc2n(C2CCCC2)c1=O CHEMBL189963 IC50 8.2 nM
c1cc2c3cnc(Nc4ccc(N5CCCCC5)nn4)nc3n(C3CCCC3)c2cn1 CHEMBL3698737 IC50 8.4 nM
O[C@H]1CCN(Cc2csc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)n2)C1 CHEMBL3702072 IC50 8.5 nM
CCN1CCN(c2ccc(Nc3ncc4scc(-c5cccc(NS(C)(=O)=O)c5)c4n3)cc2)CC1 CHEMBL4846921 IC50 8.5 nM
O[C@H]1CCN(c2ccc(Nc3ncc4c5ccnc(F)c5n(C5CCCC5)c4n3)nn2)C1 CHEMBL3702211 IC50 8.6 nM
Cn1c(=O)ccc2c3cnc(Nc4ccc(N5CCNCC5)cn4)nc3n(C3CCCC3)c21 CHEMBL3702089 IC50 8.6 nM
C[C@H]1CC[C@H](n2c3cnccc3c3cnc(Nc4ccc5c(n4)CNCC5)nc32)CC1 CHEMBL3684990 IC50 8.6 nM
O=c1[nH]ccc2c3cnc(Nc4ccc(N5CCNCC5)nn4)nc3n(C3CCCC3)c12 CHEMBL3702030 IC50 8.7 nM
c1cc2c3cnc(Nc4ccc(N[C@H]5CCNC5)nn4)nc3n(C3CCCC3)c2cn1 CHEMBL3698722 IC50 8.8 nM
CCN1CCC(Oc2cnc(Nc3cc(-c4cc(F)c5nc(C)n(C(C)C)c5c4)ncn3)cn2)CC1 CHEMBL4208875 IC50 8.8 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(C(=O)N4C[C@H]5CN[C@H](C5)C4)cn3)nc2n1C1CCCC1 CHEMBL3691554 IC50 9.0 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(N4CC5(CCCNC5)OC4=O)cn3)nc2n1C1CCCC1 CHEMBL3691644 IC50 9.0 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(N4CC5CCC(CC4=O)N5)cn3)nc2n1-c1ccccc1 CHEMBL3691664 IC50 9.0 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(N4C[C@H]5CC[C@@H](CC4=O)N5)cn3)nc2n1-c1ccccc1 CHEMBL3691666 IC50 9.0 nM
Cc1cc(-c2cnc(Nc3cnc(CN4CCN(C)CC4)cn3)s2)nc(OC2CCCCC2)n1 CHEMBL210540 IC50 9.2 nM
C[C@H]1CN(c2cnc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)cn2)CCN1 CHEMBL3698712 IC50 9.2 nM
Oc1cc(-c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)ccn1 CHEMBL3702166 IC50 9.3 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(N4CC5(CC4=O)CC4CCC(C5)N4)cn3)nc2n1C1CCCC1 CHEMBL3691655 IC50 9.5 nM
CC[C@@H](C)n1c2cnccc2c2cnc(Nc3ccc(N4CCNCC4)nn3)nc21 CHEMBL3702223 IC50 9.6 nM
CN(C)C1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CC1 CHEMBL3698648 IC50 9.6 nM
O=S1(=O)CCC(Nc2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)C1 CHEMBL3698696 IC50 9.6 nM
CCN(CCO)C1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CC1 CHEMBL3642028 IC50 9.7 nM
CC1(C)CCc2nc3c(F)cc(-c4nc(Nc5ccc(CN6CCN(C7CC7)CC6)cn5)ncc4F)cc3n21 CHEMBL4207451 IC50 9.7 nM
CN(C)C1CCN(c2ccc(Nc3ncc4c5ccnc(O)c5n(C5CCC(C)(C)CC5)c4n3)nn2)CC1 CHEMBL3702113 IC50 9.8 nM
CN(C)CC(O)COc1ccc(Nc2ncc(Br)c(N(CCCC(F)(F)F)c3ccccc3)n2)cc1 CHEMBL419720 IC50 10.0 nM
c1cnn2ncc(-c3ccnc(Nc4ccc5c(c4)OCCO5)n3)c2c1 CHEMBL361894 Ki 10.0 nM
FC(F)(F)c1cc(Nc2nccc(-c3cnn4ncccc34)n2)ccc1Cl CHEMBL188665 Ki 10.0 nM
COc1cc(Nc2nccc(-c3cnn4ncccc34)n2)cc(OC)c1 CHEMBL359999 Ki 10.0 nM
OC1CCCN(Cc2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)C1 CHEMBL3702118 IC50 10.0 nM
COc1ccc(-n2c3cnccc3c3cnc(Nc4ccc(N5CCNCC5)cn4)nc32)cc1 CHEMBL3698652 IC50 10.0 nM
COc1nccc2c3cnc(Nc4ccc(N5CCNCC5)cn4)nc3n(C3CCC(C)(C)CC3)c12 CHEMBL3702109 IC50 10.0 nM
OC1CN(C2CCN(c3ccc(Nc4ncc5c6ccncc6n(C6CCCC6)c5n4)nn3)CC2)C1 CHEMBL3642004 IC50 10.0 nM
O[C@H]1CCN(C2CCN(c3ccc(Nc4ncc5c6ccncc6n(C6CCCC6)c5n4)nn3)CC2)C1 CHEMBL3642006 IC50 10.0 nM
CC(C)[C@@H](N)C(=O)N1C2CCC1CN(C(=O)c1ccc(Nc3ncc4cc(C(=O)N(C)C)n(C5CCCC5)c4n3)nc1)C2 CHEMBL3691604 IC50 10.0 nM
CCC1CCc2nc3c(F)cc(-c4nc(Nc5ccc(CN6CCN(C)CC6)cn5)ncc4F)cc3n21 CHEMBL4217694 IC50 10.0 nM
O=C(NC1CCNCC1)c1n[nH]cc1NC(=O)c1c(Cl)cccc1Cl CHEMBL445813 IC50 10.0 nM
COCCN1CCc2nc(Nc3ncc4c5ccncc5n([C@H]5CC[C@H](C)CC5)c4n3)ccc2C1 CHEMBL3684978 IC50 10.5 nM
CN1CCOc2cccc3nc(O)c(nc23)-c2cccc3c(=O)n(sc23)CC1 CHEMBL539855 IC50 11.0 nM
O=c1c2cccc3c2sn1CCCCCCOc1cccc2nc(O)c-3nc12 CHEMBL424722 IC50 11.0 nM
CCN(CC)C1CCN(c2ccc(Nc3ncc4c5ccnc(OC)c5n(C5CCCC5)c4n3)nn2)CC1 CHEMBL3702184 IC50 11.0 nM
c1cc2c3cnc(Nc4ccc(N5CCNCC5)cn4)nc3n(C3CCCCCC3)c2cn1 CHEMBL3698669 IC50 11.0 nM
O=C(Cc1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nc1)N1CCOCC1 CHEMBL3702146 IC50 11.0 nM
c1cc2c3cnc(Nc4ccc(OC5CCNCC5)nn4)nc3n(C3CCCC3)c2cn1 CHEMBL3702170 IC50 11.0 nM
CCN(CC)C1CCN(c2ccc(Nc3ncc4c5ccnnc5n(C5CCCC5)c4n3)nc2)CC1 CHEMBL3702182 IC50 11.0 nM
CCN1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)CC1 CHEMBL3702045 IC50 11.0 nM
FC(F)(F)C1CN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CCN1 CHEMBL3702074 IC50 11.0 nM
c1cc2c3cnc(Nc4ccc(N5CCNCC5)cn4)nc3n(C3CCCCC3)c2cn1 CHEMBL3237451 IC50 11.0 nM
CC[C@@H](C)n1c2cnccc2c2cnc(Nc3ccc(N4CCNC(C)(C)C4)nn3)nc21 CHEMBL3702224 IC50 11.0 nM
c1cc2c3cnc(Nc4ccc(N5CCN(C6CC6)CC5)cn4)nc3n(C3CCCC3)c2cn1 CHEMBL3702058 IC50 11.0 nM
C[C@@H](CO)n1c2cnccc2c2cnc(Nc3ccc(N4CCNC(C)(C)C4)nn3)nc21 CHEMBL3641937 IC50 11.0 nM
FC(F)(F)CNC1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CC1 CHEMBL3642025 IC50 11.0 nM
c1ccc2c(c1)c1cnc(Nc3ccc(N4CCNCC4)nn3)nc1n2C1CCCC1 CHEMBL3702207 IC50 11.0 nM
NC1CCN(c2ccc(Nc3ncc4c5ccccc5n(C5CCCC5)c4n3)nn2)CC1 CHEMBL3702208 IC50 11.0 nM
OCC1(n2c3cnccc3c3cnc(Nc4ccc(N5CCNCC5)cn4)nc32)CCCC1 CHEMBL3698679 IC50 11.0 nM
CN(C)C1CCN(c2ccc(Nc3ncc4c5ccccc5n(C5CCCC5)c4n3)nc2)CC1 CHEMBL3702209 IC50 11.0 nM
COc1nccc2c3cnc(Nc4ccc(N5CCC(N6CCCC6)CC5)cn4)nc3n(C3CCC(C)(C)CC3)c12 CHEMBL3702111 IC50 11.0 nM
CC[C@@H](C)n1c2cnccc2c2cnc(Nc3ccc(N4CCC(NC)CC4)cn3)nc21 CHEMBL3702225 IC50 11.0 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(C(=O)N4CCC5CCC(C4)N5)cn3)nc2n1C1CCCC1 CHEMBL3691610 IC50 11.5 nM
CN1CCN(c2ccc(Nc3nccc(-c4cnn5ncccc45)n3)cc2)CC1 CHEMBL495545 IC50 12.0 nM
c1ccc(Nc2nccc(-c3cnn4ncccc34)n2)cc1 CHEMBL359554 IC50 12.0 nM
CCN(CC)Cc1cccc(Nc2nccc(-c3cnn4ncccc34)n2)c1 CHEMBL513354 IC50 12.0 nM
COc1nccc2c3cnc(Nc4ccc(N5CCNCC5)cn4)nc3n(C3CCCC3)c12 CHEMBL3698687 IC50 12.0 nM
CC1CN(c2ccc(Nc3ncc4c5cc[nH]c(=O)c5n(C5CCCC5)c4n3)nn2)CC(C)N1 CHEMBL3702033 IC50 12.0 nM
CC1CN(c2cnc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)cn2)CC(C)N1 CHEMBL3698710 IC50 12.0 nM
CNC1CCN(c2ccc(Nc3ncc4c5ccncc5n([C@@H]5CCOC5)c4n3)nc2)CC1 CHEMBL3641988 IC50 12.0 nM
C[C@H](O)CNC1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CC1 CHEMBL3642015 IC50 12.0 nM
CC[C@@H](C)n1c2cnccc2c2cnc(Nc3ccc(N4CCN[C@@H](C)C4)nn3)nc21 CHEMBL3702217 IC50 12.0 nM
N[C@H]1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)C1 CHEMBL3698738 IC50 12.0 nM
c1cc2c3cnc(Nc4cnc(NC5CCNCC5)cn4)nc3n(C3CCCC3)c2cn1 CHEMBL3639975 IC50 12.0 nM
O[C@@H]1CCN(C2CCN(c3ccc(Nc4ncc5c6ccncc6n(C6CCCC6)c5n4)nn3)CC2)C1 CHEMBL3642005 IC50 12.0 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(C(=O)N4CCC5(CC4)CNC5)cn3)nc2n1C1CCCCCC1 CHEMBL3691548 IC50 12.0 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(N4C[C@@]5(CCCNCC5)OC4=O)cn3)nc2n1C1CCCC1 CHEMBL3691642 IC50 12.0 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(N4C[C@@]5(CCCNC5)OC4=O)cn3)nc2n1C1CCCC1 CHEMBL3691646 IC50 12.0 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(N4CC5(CCNCC5)OC4=O)cn3)nc2n1C1CCCC1 CHEMBL3691656 IC50 12.0 nM
CCN1CCN(Cc2ccc(Nc3cc(-c4cc(F)c5nc(C)n(C(C)C)c5c4)c(F)cn3)nn2)CC1 CHEMBL4211162 IC50 12.1 nM
Cc1cnc(OC2CCCCC2)nc1-c1cnc(Nc2ccccn2)s1 CHEMBL212049 IC50 13.0 nM
CN1CCOc2cccc3nc(O)c(nc23)-c2cccc3c(O)n(nc23)CC1 CHEMBL1189501 IC50 13.0 nM
CNC1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCC5)c4n3)nn2)CC1 CHEMBL3641990 IC50 13.0 nM
O=C(c1ccc(Nc2ncc3c4ccnc(O)c4n(C4CCCC4)c3n2)nc1)N1CCNCC1 CHEMBL3702125 IC50 13.0 nM
C[C@H](CO)NC1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CC1 CHEMBL3641992 IC50 13.0 nM
O[C@@H]1CCCN(C2CCN(c3ccc(Nc4ncc5c6ccncc6n(C6CCCC6)c5n4)nn3)CC2)C1 CHEMBL3642007 IC50 13.0 nM
c1cc2c3cnc(Nc4ccc(N5CCNCC5)cn4)nc3n(CC3CCCCC3)c2cn1 CHEMBL3698667 IC50 13.0 nM
CC1CN(c2ccc(Nc3ncc4c5ccccc5n(C5CCCC5)c4n3)nn2)CC(C)N1 CHEMBL3702206 IC50 13.0 nM
CN(CCO)C1CCN(c2ccc(Nc3ncc4c5ccnc(F)c5n(C5CCCC5)c4n3)nc2)CC1 CHEMBL3702100 IC50 13.0 nM
CN1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CC1 CHEMBL3698638 IC50 13.0 nM
COCCCNCC(=O)N1CCN(c2ccc(Nc3ncc4c(C)c(C(C)=O)c(=O)n(C5CCCC5)c4n3)nc2)CC1 CHEMBL3905696 IC50 13.0 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(C(=O)N4CC5CCC(C4)N5)nn3)nc2n1C1CCCC1 CHEMBL3691581 IC50 13.0 nM
CN1CCCC2(C1)CN(c1ccc(Nc3ncc4cc(C(=O)N(C)C)n(C5CCCC5)c4n3)nc1)C(=O)O2 CHEMBL3691645 IC50 13.0 nM
CCN1CCN(Cc2ccc(Nc3cc(-c4cc(F)c5nc(C)n(C(C)C)c5c4)ncn3)nn2)CC1 CHEMBL4218705 IC50 13.8 nM
O=S1(=O)CCC(O)(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CC1 CHEMBL3702165 IC50 14.0 nM
CN(C)[C@H]1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)C1 CHEMBL3702188 IC50 14.0 nM
C[C@H](O)Cn1c2cnccc2c2cnc(Nc3ccc(N4CCN[C@@H](C)C4)nn3)nc21 CHEMBL3641970 IC50 14.0 nM
Oc1nccc2c3cnc(Nc4ccc(CN5CCNCC5)cn4)nc3n(C3CCCC3)c12 CHEMBL3702116 IC50 14.0 nM
CC1(C)CCC(n2c3cnccc3c3cnc(Nc4ccc(N5CCC(N6CCCC6)CC5)cn4)nc32)CC1 CHEMBL3702108 IC50 14.0 nM
COC(=O)[C@@]1(O)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL281948 Kd apparent 14.0 nM
CCC1CCc2nc3c(F)cc(-c4nc(Nc5ccc(CN6CCN(CC)CC6)cn5)ncc4F)cc3n21 CHEMBL4213847 IC50 14.0 nM
OC1CCN(C2CCN(c3ccc(Nc4ncc5c6ccncc6n(C6CCCC6)c5n4)nc3)CC2)CC1 CHEMBL3642018 IC50 15.0 nM
O=S(=O)(c1ccc(Nc2ncc3c4ccnc(F)c4n(C4CCCC4)c3n2)nc1)N1CCNCC1 CHEMBL3702130 IC50 15.0 nM
CCN(CC)C1CCN(c2ccc(Nc3ncc4c5ccnc(C)c5n(C5CCCC5)c4n3)nc2)CC1 CHEMBL3702056 IC50 15.0 nM
FC(F)(F)c1cccc(-n2c3cnccc3c3cnc(Nc4ccc(N5CCNCC5)cn4)cc32)c1 CHEMBL3702136 IC50 15.0 nM
CN1CCN(c2cnc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)cn2)CC1 CHEMBL3698709 IC50 15.0 nM
O[C@H]1CCN(Cc2csc(Nc3ncc4c5ccnc(F)c5n(C5CCCC5)c4n3)n2)C1 CHEMBL3702086 IC50 15.0 nM
CC[C@@H](C)n1c2cnccc2c2cnc(Nc3ccc(N4CC[C@@H](O)C4)cn3)nc21 CHEMBL3702222 IC50 15.0 nM
c1ncc2c(n1)c1cnc(Nc3ccc(N4CCNCC4)cn3)nc1n2C1CCCC1 CHEMBL3698690 IC50 15.0 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(C(=O)N4C[C@H]5C[C@@]5(N)C4)cn3)nc2n1C1CCCC1 CHEMBL3691559 IC50 15.0 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(C(=O)N4C[C@@H]5[C@@H](N)[C@@H]5C4)cn3)nc2n1C1CCCC1 CHEMBL3691585 IC50 15.0 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(N4C[C@]5(CCCNCC5)OC4=O)cn3)nc2n1C1CCCC1 CHEMBL3691643 IC50 15.0 nM
CNC(=O)c1cc2cnc(Nc3ccc(N4C[C@H]5CC[C@@H](CC4=O)N5C)cn3)nc2n1C1CCCC1 CHEMBL3691661 IC50 15.0 nM
CC(C)N1C2CCC1CN(C(=O)c1ccc(Nc3ncc4cc(C(=O)N(C)C)n(C5CCCC5)c4n3)nc1)C2 CHEMBL3691572 IC50 15.5 nM
COc1ccc(F)cc1-c1ccnc2[nH]c(C3=CCN(CC(O)CO)CC3)cc12 CHEMBL3668457 IC50 15.5 nM
CCN1CCN(Cc2ccc(Nc3ncc(F)c(-c4cc(F)c5nc6n(c5c4)CC(C)C6)n3)nc2)CC1 CHEMBL4215568 IC50 15.8 nM
c1cc(Nc2nccc(-c3cnn4ncccc34)n2)cc(-c2cocn2)c1 CHEMBL497564 IC50 16.0 nM
O=S1(=O)CC=C(c2ccc(Nc3ncc4c5ccnc(F)c5n(C5CCCC5)c4n3)nc2)CC1 CHEMBL3702173 IC50 16.0 nM
CN(C)C1CCN(C(=O)c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CC1 CHEMBL3702132 IC50 16.0 nM
C[C@H]1CN(c2ccc(Nc3ncc4c5cc[nH]c(=O)c5n(C5CCCC5)c4n3)nn2)CCN1 CHEMBL3702037 IC50 16.0 nM
O=C1COC2(CCN(c3ccc(Nc4ncc5c6ccncc6n(C6CCCC6)c5n4)nn3)CC2)CN1 CHEMBL3702152 IC50 16.0 nM
CCN1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CC1 CHEMBL3702047 IC50 16.0 nM
CC[C@H](C)n1c2cnccc2c2cnc(Nc3ccc(N4CCNC(C)(C)C4)nn3)nc21 CHEMBL3702232 IC50 16.0 nM
C[C@H]1CN(c2ccc(Nc3ncc4c5ccncc5n(C5CCC5)c4n3)nc2)CCN1 CHEMBL3702244 IC50 16.0 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(C(=O)N4CC5CCC(C4)N5)cn3)nc2n1C1CCCC1 CHEMBL3691561 IC50 16.0 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(C(=O)N4CC5(CNC5)C4)cn3)nc2n1C1CCCC1 CHEMBL3691584 IC50 16.0 nM
CCN1CCN(Cc2ccc(Nc3ncc(F)c(-c4cc(F)c5nc6n(c5c4)C(C)(C)CC6)n3)nc2C)CC1 CHEMBL4211479 IC50 16.0 nM
c1cc2c3cnc(Nc4ccc(NC5CCNCC5)nn4)nc3n(C3CCCC3)c2cn1 CHEMBL3698726 IC50 16.2 nM
COc1ccc(F)cc1-c1c(F)cnc2[nH]c(C3=CCN([C@H]4CC[C@H](C(=O)O)CC4)CC3)cc12 CHEMBL4777981 IC50 16.2 nM
C[C@H]1CC[C@H](n2c3cnccc3c3cnc(Nc4ccc5c(n4)C(O)CNC5)nc32)CC1 CHEMBL3684984 IC50 16.5 nM
c1cc2c3cnc(Nc4ccc(NC5CCNCC5)cn4)nc3n(C3CCCC3)c2cn1 CHEMBL3698700 IC50 17.0 nM
CC1(C)CN(c2ccc(Nc3ncc4c5ccncc5n(C5CCC5)c4n3)nn2)CCN1 CHEMBL3702248 IC50 17.0 nM
CC(=O)N1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CC1 CHEMBL3702057 IC50 17.0 nM
CCC(CC)n1c2cnccc2c2cnc(Nc3ccc(N4CCC(N(C)C)CC4)nn3)nc21 CHEMBL3702070 IC50 17.0 nM
CN(C)C1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCSCC5)c4n3)nn2)CC1 CHEMBL3702177 IC50 17.0 nM
COC1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)C1 CHEMBL3698704 IC50 17.0 nM
CC1CN(c2ccc(Nc3ncc4c5cc[nH]c(=O)c5n(C5CCCC5)c4n3)nc2)CC(C)N1 CHEMBL3702032 IC50 17.0 nM
CC1(C)CN(c2ccc(Nc3ncc4c5ccncc5n([C@@H]5CCOC5)c4n3)nc2)CCN1 CHEMBL3641989 IC50 17.0 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(C(=O)N4C[C@H]5CNC[C@@H](C4)C5O)cn3)nc2n1C1CCCC1 CHEMBL3691544 IC50 17.0 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(N4CC5(CCCNCC5)OC4=O)cn3)nc2n1C1CCCC1 CHEMBL3691640 IC50 17.0 nM
CCN1CCN(Cc2ccc(Nc3nccc(-c4cc(F)c5nc6n(c5c4)C(C)CC6)n3)nc2)CC1 CHEMBL4207966 IC50 17.6 nM
CCN(CC)C1CCN(c2ccc(Nc3ncc4c5ccnc(F)c5n(C5CCCC5)c4n3)nn2)CC1 CHEMBL3640010 IC50 18.0 nM
c1cc2c3cnc(Nc4ccc(N5CCNC6(CCCCC6)C5)nn4)nc3n(C3CCCC3)c2cn1 CHEMBL3702150 IC50 18.0 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(C(=O)N4C[C@@H]5C[C@]5(N)C4)cn3)nc2n1C1CCCC1 CHEMBL3914273 IC50 18.0 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(C(=O)N4CC5CNCC5C4)cn3)nc2n1C1CCCC1 CHEMBL3691575 IC50 18.0 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(N4CC5(CC6CCC(C5)N6C)OC4=O)cn3)nc2n1C1CCCC1 CHEMBL3691639 IC50 18.0 nM
CCN1CCN(Cc2ccc(Nc3ncc(F)c(-c4cc(F)c5nc6n(c5c4)CCC6)n3)nc2)CC1 CHEMBL4214566 IC50 18.0 nM
CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCN(C/C=C/C(F)(F)F)CC4)cn3)nc2n(C2CCCC2)c1=O CHEMBL5277376 IC50 18.0 nM
CCN1CCC(C(C)c2cnc(Nc3cc(-c4cc(F)c5nc(C)n(C(C)C)c5c4)ncn3)cn2)CC1 CHEMBL4203994 IC50 18.3 nM
C[C@H]1CC[C@H](n2c3cnccc3c3cnc(Nc4cc5c(cn4)CCN(CCO)C5)nc32)CC1 CHEMBL3684980 IC50 18.4 nM
CC(=O)N1Cc2ccc(Nc3ncc4c5ccncc5n([C@H]5CC[C@H](C)CC5)c4n3)nc2[C@H](C)C1 CHEMBL3684986 IC50 18.8 nM
Cc1nc(Nc2ncc(F)c(-c3cc(F)c4nc5n(c4c3)C(C)(C)CC5)n2)ccc1CN1CCNCC1 CHEMBL4207474 IC50 18.9 nM
CN(CCO)C1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CC1 CHEMBL3642013 IC50 19.0 nM
Cc1nc(Nc2ncc3c4ccnc(F)c4n(C4CCCC4)c3n2)ccc1N1CCNCC1 CHEMBL3702078 IC50 19.0 nM
CC1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)C1 CHEMBL3702028 IC50 19.0 nM
COCC(C)(C)n1c2cnccc2c2cnc(Nc3ccc(N4CCC(N(C)C)CC4)cn3)nc21 CHEMBL3702175 IC50 19.0 nM
CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCN(C(=O)CNCCN)CC4)cn3)nc2n(C2CCCC2)c1=O CHEMBL3986282 IC50 19.0 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(C(=O)N4CC5CC5(N)C4)cn3)nc2n1C1CCCC1 CHEMBL3691557 IC50 19.0 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(C(=O)N4CC5CCC(C4)N5C)cn3)nc2n1C1CCCC1 CHEMBL3691587 IC50 19.0 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(C(=O)N4CC5CCC(C4)N5C(=O)CN)cn3)nc2n1C1CCCC1 CHEMBL3691602 IC50 19.0 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(N4CCC5(CCCN5)C4=O)cn3)nc2n1C1CCCC1 CHEMBL3691650 IC50 19.0 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(N4C[C@@H]5CC[C@H](CC4=O)N5)cn3)nc2n1C1CCCCC1 CHEMBL3691668 IC50 19.0 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(N4C[C@H]5CC[C@@H](CC4=O)N5CC(F)(F)F)cn3)nc2n1C1CCCC1 CHEMBL3691679 IC50 19.0 nM
C[C@H]1CC[C@H](n2c3cnccc3c3cnc(Nc4ccc5c(n4)C(O)CN(CCO)C5)nc32)CC1 CHEMBL3684985 IC50 19.2 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL388978 Kd 20.0 nM
CC1CN(c2ccc(Nc3ncc4c5ccnc(F)c5n(C5CCCC5)c4n3)nc2)CC(C)N1 CHEMBL3702094 IC50 20.0 nM
CN(C)C1CCN(c2cnc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)cn2)CC1 CHEMBL3698715 IC50 20.0 nM
CC1(C)CN(c2ccc(Nc3ncc4c5cc[nH]c(=O)c5n(C5CCCC5)c4n3)nn2)CCN1 CHEMBL3702038 IC50 20.0 nM
Cc1nccc2c3cnc(Nc4ccc(N5CCNCC5)cn4)nc3n(C3CCCC3)c12 CHEMBL3237445 IC50 20.0 nM
CN(C)C1CCN(c2ccc(Nc3ncc4c5ccnc(Cl)c5n(C5CCCC5)c4n3)nn2)CC1 CHEMBL3702061 IC50 20.0 nM
C[C@@H](O)[C@@H](C)Oc1nc(Nc2ccc(S(=O)(=O)C3CC3)cc2)ncc1C(F)(F)F CHEMBL3644032 IC50 20.0 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(C(=O)N4CC5CCC(C4)N5C(=O)C4CCCN4)cn3)nc2n1C1CCCC1 CHEMBL3691603 IC50 20.0 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(N4CC5(CC6CCC(C5)N6)OC4=O)cn3)nc2n1C1CCCC1 CHEMBL3691638 IC50 20.0 nM
CN1CCCC2(CC1)CN(c1ccc(Nc3ncc4cc(C(=O)N(C)C)n(C5CCCC5)c4n3)nc1)C(=O)O2 CHEMBL3691641 IC50 20.0 nM
CCN1CCN(Cc2ccc(Nc3ncc(F)c(-c4cc(F)c5nc6n(c5c4)CC(C)(C)C6)n3)nc2)CC1 CHEMBL4207804 IC50 20.0 nM
CC1CN(CCO)Cc2ccc(Nc3ncc4c5ccncc5n([C@H]5CC[C@H](C)CC5)c4n3)nc21 CHEMBL3684983 IC50 20.3 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(N4CC5CCC(C4)N5)nn3)nc2n1C1CCCCC1 CHEMBL3691662 IC50 20.5 nM
CC1(C)CN(c2ccc(Nc3ncc4c5ccncc5n([C@@H]5CCOC5)c4n3)nn2)CCN1 CHEMBL3641987 IC50 21.0 nM
CNC1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCC5)c4n3)nc2)CC1 CHEMBL3702245 IC50 21.0 nM
CN(C)C1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCC5)c4n3)nc2)CC1 CHEMBL3702241 IC50 21.0 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(C(=O)N4CC5CCC4C5O)cn3)nc2n1C1CCCCCC1 CHEMBL3691550 IC50 21.0 nM
Cc1nc(Nc2ncc3cc(C(=O)N(C)C)n(C4CCCC4)c3n2)ccc1C(=O)N1CC2CCC(C1)N2 CHEMBL3691592 IC50 21.0 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(C(=O)N4CC5CCC(C4)N5)cn3)nc2n1[C@H]1C[C@@H]2CC[C@H]1C2 CHEMBL3691616 IC50 21.0 nM
Cc1cc(C)c(CNc2nc(N[C@@H](C)[C@@H](C)O)nc3c2ncn3C(C)C)cn1 CHEMBL4579344 IC50 21.0 nM
CN(C)C1CCN(S(=O)(=O)c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CC1 CHEMBL3702131 IC50 21.2 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(N4C(=O)CN5CCC4CC5)cn3)nc2n1C1CCCCCC1 CHEMBL3691633 IC50 21.5 nM
CNc1nc(C)c(-c2ccnc(Nc3ccc(N4CCN(C(C)=O)CC4)cc3)n2)s1 CHEMBL1083785 Ki 22.0 nM
C1=CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)CC1 CHEMBL3702156 IC50 22.0 nM
CN(C)C1CCN(c2ccc(Nc3ncc4c5ccccc5n(C5CCCC5)c4n3)nn2)CC1 CHEMBL3702200 IC50 22.0 nM
c1cc2c3cnc(Nc4cnc(N5CCOCC5)cn4)nc3n(C3CCCC3)c2cn1 CHEMBL3698714 IC50 22.0 nM
CC[C@@H](C)n1c2cnccc2c2cnc(Nc3ccc(N4CC[C@@H](O)C4)nn3)nc21 CHEMBL3702219 IC50 22.0 nM
CC[C@H](C)n1c2cnccc2c2cnc(Nc3ccc(N4CC[C@@H](O)C4)nn3)nc21 CHEMBL3702237 IC50 22.0 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(C(=O)N4CC5CCC(C4)N5CCO)cn3)nc2n1C1CCCC1 CHEMBL3691571 IC50 22.0 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(C(=O)N4CC5CCC(C4)C5N(C)C)cn3)nc2n1C1CCCC1 CHEMBL3691577 IC50 22.0 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(N4CC5CCC(C4)N5)cn3)nc2n1C1CCCC1 CHEMBL3691649 IC50 22.5 nM
CN1CC[C@H](c2c(O)cc(O)c3c(=O)cc(/C=C/c4c(Cl)cccc4Cl)oc23)[C@H](O)C1 CHEMBL4079206 IC50 22.5 nM
CN(C)C1CCN(c2ccc(Nc3ncc4c5ccncc5n([C@H]5CC[C@H](C)CC5)c4n3)nn2)CC1 CHEMBL3237710 IC50 23.0 nM
c1cc2c3cnc(Nc4ccc(N5CCC(N6CCCC6)CC5)nn4)nc3n(C3CCCC3)c2cn1 CHEMBL3641993 IC50 23.0 nM
Cc1cc(Nc2ncc3cc(C(=O)N(C)C)n(C4CCCC4)c3n2)ncc1C(O)N1CC2CCC(C1)N2 CHEMBL3691593 IC50 23.0 nM
C=CC(=O)N1CCN(c2ccc(Nc3ncc4c(C)c(C(C)=O)c(=O)n(C5CCCC5)c4n3)nc2)CC1 CHEMBL4860767 IC50 23.0 nM
c1cc2c3cnc(Nc4ccc(N5CCNCC5)nn4)nc3n([C@@H]3CCOC3)c2cn1 CHEMBL3641985 IC50 24.0 nM
COC(=O)CNC1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CC1 CHEMBL3642027 IC50 24.0 nM
C[C@@H](Oc1nc(Nc2ccc(S(C)(=O)=O)cc2)ncc1C(F)(F)F)C(C)(C)O CHEMBL3644034 IC50 24.0 nM
C[C@@H](O)[C@@H](C)Oc1nc(Nc2ccc(S(C)(=O)=O)cc2)ncc1C(F)(F)F CHEMBL3644033 IC50 24.0 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(C(=O)N4CCN5CCC4CC5)cn3)nc2n1C1CCCC1 CHEMBL3691590 IC50 24.0 nM
CCc1nn2ncccc2c1-c1ccnc(Nc2ccc(N3CCN(C)CC3)cc2)n1 CHEMBL496360 IC50 25.0 nM
N#Cc1ccc(Nc2nccc(-c3cnn4ncccc34)n2)cc1 CHEMBL359794 IC50 25.0 nM
CCN1CCN(c2ccc(Nc3ncc4c(C)c(C(C)=O)c(=O)n(C5CCCC5)c4n3)nc2)CC1 CHEMBL3954429 IC50 25.0 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(C(=O)N4CC5CCC(C4)N5)cn3)nc2n1C1CCC1 CHEMBL3691597 IC50 25.0 nM
Cc1nc(Nc2ncc(F)c(-c3cc(F)c4nc5n(c4c3)C(C)(C)CC5)n2)ccc1CN1CCN(C)CC1 CHEMBL4216447 IC50 25.0 nM
CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCN(C(=O)/C(C#N)=C/c5ccccc5)CC4)cn3)nc2n(C2CCCC2)c1=O CHEMBL5277470 IC50 25.0 nM
CN1CCN(c2ccc(Nc3nccc(-c4cnn5nc(-c6ccc(F)cc6)ccc45)n3)cc2)CC1 CHEMBL522718 IC50 26.0 nM
c1cc2c3cnc(Nc4ccc(N5CCC(N6CCCC6)CC5)cn4)nc3n(C3CCCC3)c2nn1 CHEMBL3702105 IC50 26.0 nM
CC(CO)N1C2CCC1CN(C(=O)c1ccc(Nc3ncc4cc(C(=O)N(C)C)n(C5CCCC5)c4n3)nc1)C2 CHEMBL3691578 IC50 26.0 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(N4CCN(CCO)CC4)cn3)nc2n1C1CCCC1 CHEMBL3654258 IC50 26.0 nM
CC[C@@H](Nc1nc(NCc2cnc(C)cc2C)c2ncn(C(C)C)c2n1)[C@H](C)O CHEMBL5195030 IC50 26.0 nM
COC(=O)N1CCN(c2ccc(Nc3ncc4c5ccnc(F)c5n(C5CCCC5)c4n3)nc2)CC1 CHEMBL3702097 IC50 26.2 nM
N#Cc1nccc2c3cnc(Nc4ccc(N5CCNCC5)cn4)nc3n(C3CCCC3)c12 CHEMBL3237447 IC50 27.0 nM
NC1[C@H]2CN(c3ccc(Nc4ncc5c6ccncc6n(C6CCCC6)c5n4)nn3)C[C@@H]12 CHEMBL3702174 IC50 27.0 nM
CN(C)C1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCC5)c4n3)nn2)CC1 CHEMBL3702247 IC50 27.0 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(C(=O)N4CC5CCCC(C4)N5)cn3)nc2n1C1CCCC1 CHEMBL3691594 IC50 27.0 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(N4CC5CC5(N)C4)cn3)nc2n1C1CCCC1 CHEMBL3691617 IC50 27.0 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(N4CCN5CCC[C@@H]5C4=O)cn3)nc2n1C1CCCC1 CHEMBL3691682 IC50 27.0 nM
CCN1CCN(Cc2ccc(Nc3ncc(F)c(-c4cc(F)c5nc6n(c5c4)C(C)CC6)n3)nc2)CC1 CHEMBL4212542 IC50 27.0 nM
FC(F)(F)c1cnc(Nc2ccc3[nH]cnc3c2)nc1Nc1ccccc1Cl CHEMBL194721 IC50 29.0 nM
Oc1nc2cccc3c2nc1-c1cccc2c(O)n(nc12)CCN1CC[C@@H](C1)O3 CHEMBL385415 IC50 29.0 nM
CN1CCN(c2ccc(Nc3ncc4ccn(C5CC6CCC5C6)c4n3)cc2)CC1 CHEMBL214609 IC50 29.0 nM
CN1CCN(c2ccc(Nc3ncc4c5cc[nH]c(=O)c5n(C5CCCC5)c4n3)nn2)CC1 CHEMBL3702036 IC50 29.0 nM
Cc1ccc2c(-c3ccnc(Nc4cccc(C(F)(F)F)c4)n3)cnn2n1 CHEMBL187006 Ki 30.0 nM
C[C@]12O[C@H](C[C@]1(O)CO)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)CNC4=O CHEMBL603469 Kd 30.0 nM
CCC(C)(C)n1c2cnccc2c2cnc(Nc3ccc(N4CCNCC4)cn3)nc21 CHEMBL3702064 IC50 30.0 nM
c1ccc2c(c1)CCC2n1c2cnccc2c2cnc(Nc3ccc(N4CCNCC4)cn3)nc21 CHEMBL3698660 IC50 30.0 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(C(=O)N4CC5CNCC(C4)O5)cn3)nc2n1C1CCCC1 CHEMBL3691589 IC50 30.0 nM
CN1CCN(c2ccc(Nc3ncc4ccn(C5CCCCC5)c4n3)cc2)CC1 CHEMBL214329 IC50 31.0 nM
CN1CCN(c2ccc(Nc3ncc4c5ccccc5n(C5CCCC5)c4n3)nn2)CC1 CHEMBL3702201 IC50 31.0 nM
CC1CN(c2ccc(Nc3ncc4c5ccccc5n(C5CCCC5)c4n3)nc2)CC(C)N1 CHEMBL3702203 IC50 31.0 nM
CC1CNCc2ccc(Nc3ncc4c5ccncc5n([C@H]5CC[C@H](C)CC5)c4n3)nc21 CHEMBL3684981 IC50 31.3 nM
COc1cc(-c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)ccn1 CHEMBL3702164 IC50 32.0 nM
CN(C)C1CCN(c2ccc(Nc3ncc4c5ccncc5n([C@@H]5CCOC5)c4n3)nc2)CC1 CHEMBL3641948 IC50 32.0 nM
CC(=O)OCOC(=O)N1CCN(c2ccc(Nc3ncc4c(C)c(C(C)=O)c(=O)n(C5CCCC5)c4n3)nc2)CC1 CHEMBL3972685 IC50 32.0 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(N4CC5COCC(CC4=O)N5)cn3)nc2n1C1CCCC1 CHEMBL3691680 IC50 32.0 nM
C[C@H](O)Cn1c2cnccc2c2cnc(Nc3ccc(N4CCNC(C)(C)C4)nn3)nc21 CHEMBL3641971 IC50 33.0 nM
COC(=O)CC1CCN(c2ccc(Nc3ncc4c5ccnc(F)c5n(C5CCCC5)c4n3)nc2)CC1 CHEMBL3702080 IC50 33.0 nM
Cc1cc(-c2cnc(Nc3ccccn3)s2)nc(OC2CCCCC2)n1 CHEMBL427045 IC50 34.0 nM
c1cc2c3cnc(Nc4ccc(CN5CCNCC5)cn4)nc3n(C3CCCC3)c2cn1 CHEMBL3702114 IC50 34.0 nM
c1cc2c3cnc(Nc4ccc(N5CCNCC5)cn4)cc3n(C3CCCC3)c2cn1 CHEMBL3702138 IC50 34.0 nM
CC(C)N1[C@@H]2CC[C@H]1CN(c1ccc(Nc3ncc4cc(C(=O)N(C)C)n(C5CCCC5)c4n3)nc1)C(=O)C2 CHEMBL3691678 IC50 34.0 nM
COc1ccc(NC(=S)NC(=O)c2cn(-c3ccccc3)nc2-c2ccc(OC)cc2)cc1 CHEMBL2426395 IC50 35.0 nM
Fc1nccc2c3cnc(Nc4ccc(OC5CCNCC5)nn4)nc3n(C3CCCC3)c12 CHEMBL3702171 IC50 35.0 nM
O=C(O)Cc1ccc(-n2c3cnccc3c3cnc(Nc4ccc(N5CCNCC5)cn4)cc32)cc1 CHEMBL3702140 IC50 35.0 nM
C[C@H]1CN(c2ccc(Nc3ncc4c5ccncc5n([C@H]5CCC[C@@H]5O)c4n3)nn2)CCN1 CHEMBL3641965 IC50 35.0 nM
CN(C)CCCN(C)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nn1 CHEMBL3702190 IC50 35.0 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(N4CCN5CCCCC5C4=O)cn3)nc2n1C1CCCCC1 CHEMBL3691637 IC50 35.0 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(N4CCCC5(CCNCC5)C4=O)cn3)nc2n1C1CCCC1 CHEMBL3691652 IC50 35.5 nM
CCN1CCN(Cc2cnc(Nc3cc(-c4cc(F)c5nc(C)n(C(C)C)c5c4)ncn3)nc2)CC1 CHEMBL4213770 IC50 35.9 nM
CC[C@@H](C)n1c2cnccc2c2cnc(Nc3ccc(N4CCC(N(C)C)CC4)nn3)nc21 CHEMBL3702216 IC50 36.0 nM
c1cc2c3cnc(Nc4ccc(N5CCNCC5)cn4)nc3n(C3CCCC3)c2nn1 CHEMBL3237448 IC50 36.0 nM
O=C(CO)N1CCc2nc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)ccc2C1 CHEMBL3684989 IC50 36.0 nM
O=C(O)CC1CCN(c2ccc(Nc3ncc4c5ccnc(F)c5n(C5CCCC5)c4n3)nc2)CC1 CHEMBL3702081 IC50 37.0 nM
CN(C)CC(O)COc1ccc(Nc2nccc(-c3cnn4nc(N5CCOCC5)ccc34)n2)cc1 CHEMBL521871 IC50 38.0 nM
CCNc1nc(C)c(-c2ccnc(Nc3ccc(CNC(C)=O)cc3)n2)s1 CHEMBL1084715 Ki 38.0 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(C(=O)N4CC5CCC4C5O)cn3)nc2n1C1CCCC1 CHEMBL3691569 IC50 38.0 nM
COc1ccc(NC(=S)NC(=O)c2cn(-c3ccccc3)nc2-c2ccc(F)cc2)cc1 CHEMBL2426391 IC50 39.0 nM
CC(=O)N1C2CCC1CN(C(=O)c1ccc(Nc3ncc4cc(C(=O)N(C)C)n(C5CCCCCC5)c4n3)nc1)C2 CHEMBL3691551 IC50 39.0 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(C(=O)N4CC5COCC(C4)N5)cn3)nc2n1C1CCCC1 CHEMBL3691611 IC50 39.0 nM
CCN1CCN(Cc2ccc(Nc3ncc(F)c(-c4cc(F)c5nc6n(c5c4)C(C)CC6)n3)nc2C)CC1 CHEMBL4215126 IC50 39.0 nM
COc1ccc(NC(=S)NC(=O)c2cn(-c3ccccc3)nc2-c2ccc(Cl)cc2)cc1 CHEMBL2426387 IC50 40.0 nM
COc1ccc(NC(=S)NC(=O)c2cn(-c3ccccc3)nc2-c2ccc(C)cc2)cc1 CHEMBL2426383 IC50 40.0 nM
O=S1(=O)CCC(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CC1 CHEMBL3702172 IC50 40.0 nM
C[C@H](CO)n1c2cnccc2c2cnc(Nc3ccc(N4CCNCC4)cn3)nc21 CHEMBL3641933 IC50 40.0 nM
CN1CCN(c2ccc(Nc3ncc4c5ccccc5n(C5CCCC5)c4n3)nc2)CC1 CHEMBL3702198 IC50 40.0 nM
Cc1nccc2c3cnc(Nc4ccc(N5CCC(N(C)C)CC5)cn4)nc3n(C3CCCC3)c12 CHEMBL3702055 IC50 41.0 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(N4CC5CC4CN5)cn3)nc2n1C1CCCC1 CHEMBL3691648 IC50 41.0 nM
COc1ccc(NC(=S)NC(=O)c2cn(-c3ccccc3)nc2-c2ccccc2)cc1 CHEMBL2426399 IC50 42.0 nM
O[C@@H]1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCC5)c4n3)nc2)C1 CHEMBL3641991 IC50 42.0 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(N4CC5CCC(N5)C4=O)cn3)nc2n1C1CCCCCC1 CHEMBL3691619 IC50 42.0 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(N4CC5(CC6CCC(C5)N6)OC4=O)cn3)nc2n1C1CCCCC1 CHEMBL3691631 IC50 42.5 nM
COC1CCN(c2cnc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)cn2)C1 CHEMBL3698717 IC50 43.0 nM
O[C@@H]1CCC[C@@H]1n1c2cnccc2c2cnc(Nc3ccc(N4CCNCC4)cn3)nc21 CHEMBL3641920 IC50 44.0 nM
O[C@@H]1CCN(c2ccc(Nc3ncc4c5ccncc5n([C@H]5CCC[C@@H]5O)c4n3)nn2)C1 CHEMBL3641966 IC50 44.0 nM
CC1(C)CN(c2ccc(Nc3ncc4c5ccncc5n(C5CCC5)c4n3)nc2)CCN1 CHEMBL3702243 IC50 44.0 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(C(=O)N4[C@@H]5CNC[C@H]4COC5)cn3)nc2n1C1CCCC1 CHEMBL3691583 IC50 44.0 nM
CC(C)Oc1ccc2c(-c3ccnc(Nc4ccc(N5CCN(C)CC5)cc4)n3)cnn2n1 CHEMBL496162 IC50 45.0 nM
c1cc(-c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)ccn1 CHEMBL3702162 IC50 45.0 nM
C[C@@H](CO)n1c2cnccc2c2cnc(Nc3ccc(N4CCNCC4)cn3)nc21 CHEMBL3237449 IC50 45.0 nM
CNC1CCN(c2ccc(Nc3ncc4c5ccncc5n([C@@H](C)CO)c4n3)nn2)CC1 CHEMBL3641931 IC50 45.0 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(C(=O)N4CC5C[C@@H]4CN5)cn3)nc2n1C1CCCC1 CHEMBL3691591 IC50 45.0 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(N4C[C@@H]5CC[C@H](CC4=O)N5C)cn3)nc2n1C1CCCC1 CHEMBL3691677 IC50 45.0 nM
O[C@@H]1CCN(c2ccc(Nc3ncc4c5ccccc5n(C5CCCC5)c4n3)nc2)C1 CHEMBL3702204 IC50 46.0 nM
CC(=O)N1C2CCC1CN(C(=O)c1ccc(Nc3ncc4cc(C(=O)N(C)C)n(C5CCCC5)c4n3)nc1)C2 CHEMBL3691570 IC50 46.0 nM
Cc1ccc(Cl)c(N(CC#N)c2cc(Nc3ccc(OC[C@@H](O)CN(C)C)cc3)ncn2)c1 CHEMBL211514 IC50 47.0 nM
C[C@H]1CN(c2ccc(Nc3ncc4c5ccccc5n(C5CCCC5)c4n3)nn2)CCN1 CHEMBL3702202 IC50 47.0 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(C(=O)N4CCN5CCC[C@@H]5C4)cn3)nc2n1C1CCCC1 CHEMBL3691564 IC50 47.0 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(C(=O)N4CC5CCC(C4)N5)cn3)nc2n1C1C[C@H]2CC[C@@H]1C2 CHEMBL3691615 IC50 47.0 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(N4C[C@@H]5CC[C@H](CC4=O)N5)cn3)nc2n1-c1ccccc1 CHEMBL3691665 IC50 48.0 nM
CN(C)C1CCN(c2ccc(Nc3ncc4c5cc[nH]c(=O)c5n(C5CCCC5)c4n3)nc2)CC1 CHEMBL3702031 IC50 48.1 nM
c1cc(-c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)ccn1 CHEMBL3702161 IC50 49.0 nM
c1csc(Cn2c3cnccc3c3cnc(Nc4ccc(N5CCNCC5)cn4)cc32)c1 CHEMBL3702139 IC50 49.0 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(C(=O)N4CC5CC(C4)N(CC(F)(F)F)C5)cn3)nc2n1C1CCCC1 CHEMBL3691555 IC50 49.0 nM
CNC(=O)c1cc2cnc(Nc3ccc(C(=O)N4C[C@@H]5C[C@H]4CN5)cn3)nc2n1C1CCCC1 CHEMBL3691567 IC50 49.0 nM
Sc1nnc(-c2c[nH]c3ccccc23)n1/N=C/c1cccc(Br)c1 CHEMBL5426856 IC50 49.0 nM
CCC1Cc2nc3c(F)cc(-c4nc(Nc5ccc(CN6CCN(CC)CC6)cn5)ncc4F)cc3n2C1 CHEMBL4213109 IC50 49.7 nM
CN(C)CC(O)COc1ccc(Nc2cc(N(CC#N)c3cc(Cl)ccc3Cl)ncn2)cc1 CHEMBL101119 IC50 50.0 nM
Cc1nn2ncccc2c1-c1ccnc(Nc2ccc(N3CCN(C)CC3)cc2)n1 CHEMBL524086 IC50 50.0 nM
CNC(=O)c1ccc(Nc2nccc(-c3cnc(C)n3C(C)C)n2)cc1F CHEMBL455428 IC50 50.0 nM
COc1nccc2c3cnc(Nc4ccc(N5CCC(N(C)C)CC5)cn4)nc3n(C3CCCC3)c12 CHEMBL3702054 IC50 50.0 nM
C[C@H](CO)n1c2cnccc2c2cnc(Nc3ccc(N4CCC(N(C)C)CC4)cn3)nc21 CHEMBL3641934 IC50 50.0 nM
CC[C@H](C)n1c2cnccc2c2cnc(Nc3ccc(N4CCNC(C)(C)C4)cn3)nc21 CHEMBL3702228 IC50 51.0 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(N4C(=O)CN5CCC4CC5)cn3)nc2n1C1CCCC1 CHEMBL3691634 IC50 51.0 nM
C[C@H]1CC[C@H](n2c3cnccc3c3cnc(Nc4ccc5c(n4)CCN(CCC(F)(F)F)C5)nc32)CC1 CHEMBL3680384 IC50 52.4 nM
Cc1nc(N)sc1-c1ccnc(Nc2cccc([N+](=O)[O-])c2)n1 CHEMBL298445 Ki 53.0 nM
CNC1CCN(c2ccc(Nc3ncc4c5ccncc5n([C@H](C)CO)c4n3)nn2)CC1 CHEMBL3641944 IC50 53.0 nM
c1cc2c3cnc(Nc4ccc(N5CCNCC5)nn4)nc3n(C3CCC3)c2cn1 CHEMBL3702246 IC50 54.0 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(N4C[C@H]5CC[C@@H](CC4=O)N5)cn3)nc2n1C1CCC1 CHEMBL3691672 IC50 54.0 nM
CC1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)C1 CHEMBL3698705 IC50 56.0 nM
[C-]#[N+]CC1CCN(c2ccc(Nc3ncc4c5ccnc(F)c5n(C5CCCC5)c4n3)nc2)CC1 CHEMBL3640009 IC50 56.0 nM
Sc1nnc(-c2c[nH]c3ccccc23)n1/N=C/c1ccc(Cl)cc1 CHEMBL5396524 IC50 56.0 nM
COc1ccc(Nc2nc(Nc3ccc4[nH]cnc4c3)ncc2C(F)(F)F)cc1 CHEMBL372464 IC50 57.0 nM
C[C@H](C1CCCCC1)n1c2cnccc2c2cnc(Nc3ccc(N4CCNCC4)cn3)nc21 CHEMBL3698663 IC50 57.0 nM
CN(C)C1CCN(c2ccc(Nc3ncc4c5ccncc5n([C@H]5CCC[C@@H]5O)c4n3)nc2)CC1 CHEMBL3641957 IC50 57.0 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(N4CCN5CCCC5C4=O)cn3)nc2n1C1CCCCC1 CHEMBL3691635 IC50 57.0 nM
CN(C)C1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCS(=O)(=O)CC5)c4n3)nc2)CC1 CHEMBL3702181 IC50 59.0 nM
CNC1CCN(c2ccc(Nc3ncc4c5ccncc5n([C@@H]5CCOC5)c4n3)nn2)CC1 CHEMBL3641986 IC50 59.0 nM
COC(=N)c1nc2ccc3ncnc(Nc4ccc(Cl)cc4Cl)c3c2s1 CHEMBL2386747 IC50 59.0 nM
COc1cccc(Nc2nccc(-c3cnn4ncccc34)n2)c1 CHEMBL187081 Ki 60.0 nM
Fc1cc(F)cc(Nc2nccc(-c3cnn4ncccc34)n2)c1 CHEMBL184510 Ki 60.0 nM
CC1(C)CN(c2ccc(Nc3ncc4c5ccccc5n(C5CCCC5)c4n3)nn2)CCN1 CHEMBL3702199 IC50 60.0 nM
C[C@H](CO)Nc1nc(Nc2ccc(S(N)(=O)=O)cc2)ncc1Br CHEMBL4741442 IC50 61.0 nM
C[C@H](CO)Nc1nc(Nc2ccc(S(N)(=O)=O)cc2)ncc1Br CHEMBL4764656 IC50 61.0 nM
CC1(C)CN(C(=O)Cc2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CCN1 CHEMBL3702144 IC50 62.0 nM
C[C@H](CO)n1c2cnccc2c2cnc(Nc3ccc(N4CCNC(C)(C)C4)cn3)nc21 CHEMBL3641941 IC50 62.0 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(N4C[C@@H]5CC[C@H](CC4=O)N5S(C)(=O)=O)cn3)nc2n1C1CCCC1 CHEMBL3691673 IC50 62.0 nM
CN1CC[C@@H](c2c(O)cc(O)c3c(=O)cc(-c4ccccc4Cl)oc23)[C@@H]1CO CHEMBL3991935 IC50 63.0 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(C(=O)N4CCN5CCCC5C4)cn3)nc2n1C1CCCC1 CHEMBL3691563 IC50 64.0 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(C(=O)N4CC5CCC(C4)O5)cn3)nc2n1C1CCCC1 CHEMBL3691613 IC50 64.5 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(C(=O)N4CC5CC5(N(C)C)C4)cn3)nc2n1C1CCCC1 CHEMBL3691560 IC50 65.0 nM
CC(C)(C)c1cnc(CSc2cnc(NC(=O)C3CCNCC3)s2)o1 CHEMBL296468 Kd 66.0 nM
O=C(c1cnc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)s1)N1CCNCC1 CHEMBL3698685 IC50 66.0 nM
CC1(C)CN(c2ccc(Nc3ncc4c5ccncc5n([C@H]5CCC[C@H]5O)c4n3)nc2)CCN1 CHEMBL3641919 IC50 66.0 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(N4CC5(CC4=O)CC4CCC(C5)N4)cn3)nc2n1C1CCCOC1 CHEMBL3691657 IC50 66.0 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(C(=O)N4CCC5COCC(C4)N5)cn3)nc2n1C1CCCC1 CHEMBL3691614 IC50 67.0 nM
CN(C)CC(=O)N1CCN(c2ccc(Nc3ncc4c5ccnc(F)c5n(C5CCCC5)c4n3)nc2)CC1 CHEMBL3702098 IC50 68.0 nM
C[C@H](O)Cn1c2cnccc2c2cnc(Nc3ccc(N4CCC(N(C)C)CC4)cn3)nc21 CHEMBL3641980 IC50 69.0 nM
Cc1ccc2c(-c3ccnc(Nc4ccc5c(c4)OCCO5)n3)cnn2n1 CHEMBL434337 Ki 70.0 nM
c1cc2c3cnc(Nc4ccc(N5CCNC6(CCC6)C5)nn4)nc3n(C3CCCC3)c2cn1 CHEMBL3702148 IC50 70.0 nM
C[C@H]1CN(c2ccc(Nc3ncc4c5ccncc5n([C@H]5CCC[C@H]5O)c4n3)nc2)CCN1 CHEMBL3641918 IC50 71.0 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(N4CCN5CCCCC5C4=O)cn3)nc2n1C1CCCC1 CHEMBL3691636 IC50 71.0 nM
C[C@H](O)Cn1c2cnccc2c2cnc(Nc3ccc(N4CC[C@@H](O)C4)cn3)nc21 CHEMBL3641982 IC50 72.0 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(C(=O)N4C5CCC4CNC5)cn3)nc2n1C1CCCC1 CHEMBL3691565 IC50 72.5 nM
C[C@H]1CC[C@H](n2c3cnccc3c3cnc(Nc4ccc5c(n4)CCN(CCF)C5)nc32)CC1 CHEMBL3680386 IC50 72.8 nM
CNC1CCN(c2ccc(Nc3ncc4c5ccncc5n(C[C@@H](C)O)c4n3)nc2)CC1 CHEMBL3641983 IC50 73.0 nM
C[C@H]1CN(c2ccc(Nc3ncc4c5ccncc5n([C@@H](C)CO)c4n3)nn2)CCN1 CHEMBL3641935 IC50 73.0 nM
c1cncc(-c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)c1 CHEMBL3702169 IC50 73.0 nM
CC(C)(CO)Cn1c2cnccc2c2cnc(Nc3ccc(N4CCNCC4)cn3)nc21 CHEMBL3698680 IC50 73.0 nM
COc1cc(/C=N/n2c(S)nnc2-c2c[nH]c3ccccc23)cc(OC)c1OC CHEMBL5401951 IC50 73.0 nM
CN(C)C1CCN(c2ccc(Nc3ncc4c5ccncc5n(CCCO)c4n3)nc2)CC1 CHEMBL3641909 IC50 74.0 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(C(=O)N4CC5CCC(C4)N5)cn3)nc2n1C(C)(C)C CHEMBL3691600 IC50 74.0 nM
C[C@H](O)Cn1c2cnccc2c2cnc(Nc3ccc(N4CCN[C@@H](C)C4)cn3)nc21 CHEMBL3641981 IC50 75.0 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(C(=O)N4C[C@@H]5C[C@H]4C[C@H]5O)cn3)nc2n1C1CCCC1 CHEMBL3691574 IC50 75.0 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(C(=O)N4CC5CCC(C4)N5)cn3)nc2n1C1CCCOC1 CHEMBL3691606 IC50 76.0 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(N4CC5CCC(CC4=O)N5)nn3)nc2n1C1CCCC1 CHEMBL3691618 IC50 76.0 nM
C[C@H](O)Cn1c2cnccc2c2cnc(Nc3ccc(N4CCNCC4)cn3)nc21 CHEMBL3641979 IC50 77.0 nM
CN1CC2(C)CN(C(=O)c3ccc(Nc4ncc5cc(C(=O)N(C)C)n(C6CCCC6)c5n4)nc3)CC(C)(C1)C2O CHEMBL3691582 IC50 77.0 nM
c1cnn2ncc(-c3ccnc(NC4CC4)n3)c2c1 CHEMBL525194 IC50 80.0 nM
OCCn1c2cnccc2c2cnc(Nc3ccc(N4CCNCC4)nn3)nc21 CHEMBL3641978 IC50 80.0 nM
C[C@H]1CN(c2ccc(Nc3ncc4c5ccncc5n(CCCO)c4n3)nc2)CCN1 CHEMBL3641910 IC50 80.0 nM
C[C@@H](CO)n1c2cnccc2c2cnc(Nc3ccc(N4CCNC(C)(C)C4)cn3)nc21 CHEMBL3641936 IC50 85.0 nM
C[C@@H](CO)n1c2cnccc2c2cnc(Nc3ccc(N4CC[C@@H](O)C4)nn3)nc21 CHEMBL3641932 IC50 86.0 nM
CC[C@@H](C)n1c2cnccc2c2cnc(Nc3ccc(N4CCNC(C)(C)C4)cn3)nc21 CHEMBL3702242 IC50 87.0 nM
OCCCn1c2cnccc2c2cnc(Nc3ccc(N4CC[C@@H](O)C4)nn3)nc21 CHEMBL3641912 IC50 90.0 nM
CN1CC[C@@H](c2c(O)cc(O)c3c(=O)cc(-c4ccc(C(F)(F)F)cc4Cl)oc23)[C@@H]1CO CHEMBL3905910 IC50 90.0 nM
C[C@H]1CN(c2ccc(Nc3ncc4c5ccncc5n([C@@H]5CCOC5)c4n3)nn2)CCN1 CHEMBL3639408 IC50 92.0 nM
CCOC(=O)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nc1 CHEMBL3702048 IC50 93.0 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(N4CCC5(CCCN5)C4=O)cn3)nc2n1C1CCCOC1 CHEMBL3691658 IC50 93.0 nM
CN(C)C1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCSCC5)c4n3)nc2)CC1 CHEMBL3702178 IC50 96.0 nM