CN1C(=O)COc2ccc(-c3nn(Cc4ccccc4)c(=O)c4ccccc34)cc21 CHEMBL5418358 IC50 -11.6 nM
NC(=O)CN1C(=O)C(O)(CC(=O)c2ccc3ccccc3c2)c2ccccc21 CHEMBL5430630 IC50 -11.1 nM
O=C(C1=C(O)C(=O)N(CCc2c[nH]c3ccccc23)C1c1cccnc1)c1ccc(Cl)cc1 CHEMBL5408917 IC50 -11.1 nM
COc1ccc(OCC(=O)Nc2cccc(-c3nc4ccccc4c(=O)o3)c2)cc1 CHEMBL5417193 IC50 -11.0 nM
COc1ccc(F)c(F)c1C(=O)c1cnc(NC2CCN(S(C)(=O)=O)CC2)nc1N CHEMBL384304 IC50 0.1 nM
CC[C@H](CO)Nc1nc(NCc2ccccc2)c2ncn(C(C)C)c2n1 CHEMBL14762 IC50 0.2 nM
CCc1cnn2c(NCc3ccc[n+]([O-])c3)cc(N3CCCCC3CCO)nc12 CHEMBL2006674 pKi 0.3162 nM
Nc1nc(Nc2ccc(S(N)(=O)=O)cc2)nn1C(=O)c1c(F)cccc1F CHEMBL191003 pKi 0.5012 nM
NC(COc1cncc(-c2ccc3c(c2)C(=Cc2ccc[nH]2)C(=O)N3)c1)Cc1ccccc1 CHEMBL1980407 pKi 0.631 nM
CC(C)c1n[nH]c2c(NCc3ccc(-c4ccccn4)cc3)nc(NCC(C)(C)O)nc12 CHEMBL3775792 IC50 1.0 nM
CCc1cnn2c(NCc3ccc[n+]([O-])c3)cc(N3CCCC[C@H]3CCO)nc12 CHEMBL2103840 IC50 1.0 nM
Cc1cnn2c(NCc3ccc[n+]([O-])c3)cc(N3CCCC[C@@H]3CCO)nc12 CHEMBL4292930 IC50 1.0 nM
CCc1cnn2c(NCc3ccc[n+]([O-])c3)cc(C3CCCC[C@H]3CCO)nc12 CHEMBL5171657 IC50 1.0 nM
CCc1cnn2c(NCc3ccc[n+]([O-])c3)cc(N3CCCC[C@@H]3CCO)nc12 CHEMBL5266005 IC50 1.0 nM
CC(C)(CN)CNc1nc(Cl)cc(-c2c[nH]c3ncccc23)n1 CHEMBL1968930 pKi 1.259 nM
Nc1cc(-c2c[nH]c3ncccc23)cc(Cl)n1 CHEMBL1987448 pKi 1.995 nM
CN1C/C=C/CCOc2cccc(c2)-c2ccnc(n2)Nc2cccc(c2)C1 CHEMBL1944698 IC50 3.0 nM
NC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1973720 pKi 3.162 nM
CNC1CC2OC(C)(C1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL1980995 pKi 3.981 nM
O=C(Nc1ncc(C2CCC2)s1)Nc1cccc2ccncc12 CHEMBL186342 IC50 5.0 nM
O=C(Nc1cc(C2CCC2)c[nH]1)Nc1cccc2ccncc12 CHEMBL1241758 IC50 5.0 nM
COc1ccc(-c2[nH]nc3c2C(=O)c2c(NC(=O)NNC(=O)c4ccc(O)cc4)cccc2-3)cc1 CHEMBL362560 IC50 5.0 nM
CC(C)c1n[nH]c2c(NCc3ccc(-c4ccccn4)cc3)nc(N3CCOCC3)nc12 CHEMBL3775509 IC50 5.0 nM
CC(O)CNc1nc(NCc2ccc(-c3ccccn3)cc2)c2[nH]nc(C(C)C)c2n1 CHEMBL3774632 IC50 5.0 nM
CC(C)CC(=O)Nc1n[nH]c2c1CN(C(=O)C1CCN(C)CC1)C2(C)C CHEMBL1230607 IC50 5.0 nM
Clc1cc(-c2c[nH]c3ncccc23)cc(NCc2ccccc2)n1 CHEMBL1969588 pKi 5.012 nM
N#Cc1ccc(C(=O)Nc2n[nH]c3ccc(-c4cn(Cc5ccccc5)nn4)cc23)cc1 CHEMBL1990162 pKi 5.012 nM
CNCC(=O)NC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1996980 pKi 6.31 nM
CCCC(=O)Nc1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12 CHEMBL1977223 pKi 6.31 nM
O=C(Nc1cnccn1)Nc1cccc2c(O)cccc12 CHEMBL1992371 pKi 6.31 nM
CNC(=O)NC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL2005509 pKi 6.31 nM
Nc1nc(Cl)cc(-c2c[nH]c3ncccc23)n1 CHEMBL2007574 pKi 6.31 nM
O=C(Nc1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12)c1ccc(F)cc1 CHEMBL1966204 pKi 6.31 nM
CCNC(=O)NC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1992220 pKi 6.31 nM
O=C(Cc1ccc2[nH]cnc2c1)Nc1ncc(C2CCC2)s1 CHEMBL186898 IC50 7.0 nM
O=C(CCCOc1ccc(CC(=O)Nc2cc(C3CCC3)[nH]n2)cc1)NCCCCNc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O CHEMBL4864688 IC50 7.0 nM
COc1ccc2c(c1)C(=Cc1c[nH]cn1)C(=O)N2 CHEMBL2002649 pKi 7.943 nM
Cc1ccccc1-c1c(-c2ccc3[nH]nc(N)c3c2)nnn1Cc1ccccc1 CHEMBL2000029 pKi 7.943 nM
Cc1ccc(-c2cc3nc(Br)cnc3[nH]2)cc1 CHEMBL1965169 pKi 7.943 nM
N#CCOc1ccc(Nc2nc(Nc3cccc(S(N)(=O)=O)c3)ncc2Br)cc1 CHEMBL1987034 pKi 7.943 nM
CNc1nc(C)c(-c2ccnc(Nc3ccc(N4CCNCC4)cc3)n2)s1 CHEMBL1999484 pKi 7.943 nM
O=C(Nc1ncc(C2CCC2)s1)Nc1cccc2cnccc12 CHEMBL364213 IC50 8.0 nM
CC(C)c1n[nH]c2c(NCc3ccc(-c4ccccn4)cc3)nc(NCCN)nc12 CHEMBL3775470 IC50 8.0 nM
CCC(CO)Nc1nc(NCc2ccc(-c3ccccn3)cc2)c2[nH]nc(C(C)C)c2n1 CHEMBL3774932 IC50 9.0 nM
O=C(Cc1ccc2ncccc2c1)Nc1ncc(C2CCC2)s1 CHEMBL363954 IC50 10.0 nM
OC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1986943 pKi 10.0 nM
CN(C)C1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1969151 pKi 10.0 nM
COc1cc(-c2ccc3c(c2)Nc2ccc(C(=O)NCCCN(C)C)cc2NC3=O)ccc1O CHEMBL1996702 pKi 10.0 nM
O=C(Nc1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12)c1ccccc1 CHEMBL1999931 pKi 10.0 nM
O=C(Nc1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12)c1cc(F)ccc1F CHEMBL1995811 pKi 10.0 nM
Cc1nc2ccc(CC(=O)Nc3ncc(C4CCC4)s3)cc2s1 CHEMBL186470 IC50 12.0 nM
CC(=O)NCC(=O)N1C2CCC1c1cc(Nc3ncc(C(F)(F)F)c(NC4CCC4)n3)ccc12 CHEMBL1983111 pKi 12.59 nM
O=C1Cc2c([nH]c3ccc([N+](=O)[O-])cc23)-c2ccccc2N1 CHEMBL50894 pKi 12.59 nM
CN(C)CC(=O)NC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1982271 pKi 12.59 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4ccc(Cl)c(Cl)c4)c3)cc12 CHEMBL1991063 pKi 12.59 nM
O=C(Nc1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12)c1cccc(F)c1 CHEMBL2003638 pKi 12.59 nM
CCn1c(C)c(-c2ccnc(Nc3cccc(OC)c3)n2)sc1=O CHEMBL1986263 pKi 12.59 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4cccc(Cl)c4)c3)cc12 CHEMBL1974870 pKi 12.59 nM
N#Cc1cccc(C(=O)Nc2n[nH]c3ccc(-c4cn(Cc5ccccc5)nn4)cc23)c1 CHEMBL1977128 pKi 12.59 nM
COc1ccc(C(=O)Nc2n[nH]c3ccc(-c4cn(Cc5ccccc5)nn4)cc23)cc1OC CHEMBL1991078 pKi 12.59 nM
NC1CCCCC1Nc1nc(Cl)cc(-c2c[nH]c3ncccc23)n1 CHEMBL1994438 pKi 12.59 nM
CC(Nc1cncc(-n2cnc3ccc(C#N)cc32)n1)c1ccccc1F CHEMBL1977138 pKi 12.59 nM
O=C(Cc1cccc2cnccc12)Nc1ncc(C2CCC2)s1 CHEMBL184404 IC50 13.0 nM
Cc1cc2ncn(CC(=O)Nc3ncc(C4CCC4)s3)c2cc1C CHEMBL187903 IC50 13.0 nM
O=C(Nc1ncc(C2CCC2)s1)Nc1cccc2ncccc12 CHEMBL187256 IC50 13.0 nM
O=C(NC1CCNCC1)c1n[nH]cc1NC(=O)c1c(Cl)cccc1Cl CHEMBL445813 IC50 13.0 nM
O=C(NC1CCNCC1)c1n[nH]cc1NC(=O)c1c(Cl)cccc1Cl CHEMBL5440428 IC50 13.0 nM
CN(c1ncccc1CNc1nc(Nc2ccc3c(c2)CC(=O)N3)ncc1C(F)(F)F)S(C)(=O)=O CHEMBL1084546 pKi 15.85 nM
COc1cc(-c2ccc3c(c2)Nc2c(O)cccc2NC3=O)ccc1O CHEMBL550418 pKi 15.85 nM
Cn1c2ccccc2c2c3c(c4c5ccccc5n(CCC#N)c4c21)CNC3=O CHEMBL302449 pKi 15.85 nM
O=C(Cc1c[nH]c2ccccc12)Nc1ncc(C2CCC2)s1 CHEMBL186240 IC50 16.0 nM
CC(C)c1n[nH]c2c(NCc3ccc(-c4ccccn4)cc3)nc(NCC(N)CO)nc12 CHEMBL3775608 IC50 17.0 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4cccc(OC(F)(F)F)c4)c3)cc12 CHEMBL1965836 pKi 19.95 nM
O=C(Nc1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12)c1ccc(Cl)cc1 CHEMBL1987073 pKi 19.95 nM
COc1cc(-c2ccc3c(c2)Nc2ccc([N+](=O)[O-])cc2NC3=O)ccc1O CHEMBL1995740 pKi 19.95 nM
CCCCN(CCC#N)C(=O)c1ccc2nc(-c3n[nH]c4ccccc34)[nH]c2c1 CHEMBL1983348 pKi 19.95 nM
CN1CCN(c2ccc(Nc3nc(N)c(C(=O)c4c(Cl)cccc4Cl)s3)cc2)CC1 CHEMBL1989043 pKi 19.95 nM
CC(C)c1n[nH]c2c(NCc3ccc(-c4ccccn4)cc3)nc(NCC(O)CO)nc12 CHEMBL3775677 IC50 21.0 nM
CC[C@H](Nc1nc(NCc2ccccc2)c2ncn(C(C)C)c2n1)[C@@H](C)O CHEMBL4764173 IC50 21.0 nM
CC[C@H](Nc1nc(NCc2cnc(C)cc2C)c2ncn(C(C)C)c2n1)[C@@H](C)O CHEMBL3655762 IC50 21.0 nM
O=C(Cc1ccccc1)Nc1ncc(C2CCC2)s1 CHEMBL365855 IC50 25.0 nM
O=C(Nc1cc(Br)ccn1)Nc1cccc2c1C1CCCCN1C2=O CHEMBL2180854 IC50 25.0 nM
COc1cc(-c2ccc3c(c2)Nc2ccc(C(=O)NCc4cccc(F)c4)cc2NC3=O)ccc1O CHEMBL2000832 pKi 25.12 nM
CCNc1nc(C)c(-c2ccnc(Nc3ccc(N4CCN(C(C)=O)CC4)cc3)n2)s1 CHEMBL1983715 pKi 25.12 nM
O=C(Nc1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12)c1cccc(Cl)c1 CHEMBL1983595 pKi 25.12 nM
CN1CCC(c2c(O)cc(O)c3c(=O)cc(-c4ccccc4Cl)oc23)C(O)C1 CHEMBL422897 pKi 25.12 nM
Cn1cc(-c2cc3nc(Br)cnc3[nH]2)c2cc(F)ccc21 CHEMBL1993335 pKi 25.12 nM
Cc1cnc(Nc2nc(NC(C)C)ncc2Br)s1 CHEMBL1973013 pKi 25.12 nM
COc1cc(Nc2ncc([N+](=O)[O-])c(Nc3ccccc3C(N)=O)n2)cc(OC)c1OC CHEMBL1241473 pKi 25.12 nM
NC1=NC(=O)/C(=C2\CCNC(=O)c3[nH]c(Br)cc32)N1 CHEMBL361708 IC50 30.0 nM
CC(C)c1cnn2c(NCc3ccccc3)cc(N[C@@H](CO)[C@H](O)CO)nc12 CHEMBL1234833 IC50 30.0 nM
NC(=O)c1cc2c(-c3ccc(Br)cc3)cncc2s1 CHEMBL1978195 pKi 31.62 nM
Cc1cc(Nc2nc(Cl)cc(NCc3ccccc3)n2)n[nH]1 CHEMBL2005449 pKi 31.62 nM
CN(C)c1ccc(C(=O)Nc2n[nH]c3ccc(-c4cn(Cc5ccccc5)nn4)cc23)cc1 CHEMBL1992363 pKi 31.62 nM
NCCNc1cc(-c2c[nH]c3ncccc23)cc(Cl)n1 CHEMBL1972290 pKi 31.62 nM
CCCC(=O)Nc1n[nH]c2ccc(-c3cccc(F)c3F)cc12 CHEMBL1985406 pKi 31.62 nM
CS(=O)(=O)NC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1980562 pKi 31.62 nM
COc1ccc(CC(=O)Nc2cc(C3CCC3)[nH]n2)cc1 CHEMBL4846069 IC50 32.0 nM
c1ccc(Nc2ncc(-c3ccnc(OC4CCCCC4)n3)s2)nc1 CHEMBL424696 IC50 34.0 nM
CC(C)c1n[nH]c2c(NCc3ccc(-c4ccccn4)cc3)nc(N3CCCCC3CCO)nc12 CHEMBL3774979 IC50 37.0 nM
Cc1cc(=O)n2ccc(CN(C)C)c(O)c2n1 CHEMBL1988581 pKi 39.81 nM
NC(=O)c1cc2c(-c3cccc(F)c3)cncc2s1 CHEMBL1971017 pKi 39.81 nM
O=C(Nc1ncc(C2CCC2)s1)Nc1cccc2[nH]nnc12 CHEMBL186371 IC50 41.0 nM
CN1CC[C@H](c2c(O)cc(O)c3c(=O)cc(-c4ccccc4Cl)oc23)[C@H](O)C1 CHEMBL428690 Kd 43.0 nM
O=C(Nc1ccc2ncccc2c1)Nc1ncc(C2CCC2)s1 CHEMBL187015 IC50 44.0 nM
O=C(Nc1ccc2cnccc2c1)Nc1ncc(C2CCC2)s1 CHEMBL359591 IC50 44.0 nM
CC(C)c1n[nH]c2c(NCc3ccc(-c4ccccn4)cc3)nc(N[C@@H]3CCCC[C@H]3N)nc12 CHEMBL3775223 IC50 44.0 nM
O=C(Cn1ccc2ccccc21)Nc1ncc(C2CCC2)s1 CHEMBL364338 IC50 48.0 nM
CC(C)c1n[nH]c2c(NCc3ccc(-c4ccccn4)cc3)nc(NCCO)nc12 CHEMBL3775502 IC50 49.0 nM
NC1CCCCC1Nc1nccc(-c2c[nH]c3ncccc23)n1 CHEMBL1995813 pKi 50.12 nM
NS(=O)(=O)c1cccc(Nc2ncc3ccn(-c4ccccc4)c3n2)c1 CHEMBL1988163 pKi 50.12 nM
Cn1cc(-c2cc3nc(Br)cnc3[nH]2)c2cc(C#N)ccc21 CHEMBL1978562 pKi 50.12 nM
O=c1[nH]c2cc(Br)cnc2[nH]1 CHEMBL1975921 pKi 50.12 nM
CC(C)Oc1cc(Nc2nc(NC(C)c3ccc(F)cn3)ncc2Cl)n[nH]1 CHEMBL2007421 pKi 50.12 nM
CC(C)(C)c1cnc(CSc2cnc(NC(=O)C3CCNCC3)s2)o1 CHEMBL296468 pKi 50.12 nM
NC(=O)c1cc2c(-c3ccc(Br)c(F)c3F)cncc2s1 CHEMBL1999918 pKi 50.12 nM
O=c1[nH]c2ccccc2cc1-c1csc(-c2ccncc2)n1 CHEMBL235764 IC50 54.0 nM
COc1cccc(C(=O)Nc2n[nH]c3ccc(-c4cn(Cc5ccccc5)nn4)cc23)c1 CHEMBL1980435 pKi 63.1 nM
Cc1n[nH]c2cnc(-c3cncc(OCC(N)Cc4cccc(C(F)(F)F)c4)c3)cc12 CHEMBL1998159 pKi 63.1 nM
CC(C)CNC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL2006456 pKi 63.1 nM
Clc1cc(-c2c[nH]c3ncccc23)nc(NC2CCOCC2)n1 CHEMBL1980253 pKi 63.1 nM
Cn1cc(-c2cc3nc(Br)cnc3[nH]2)c2ccccc21 CHEMBL1978167 pKi 63.1 nM
CCOc1ccc(C=C2SC(=N)NC2=O)c(O)c1 CHEMBL1971289 pKi 63.1 nM
CCCC(=O)Nc1n[nH]c2nnc(-c3cccc(F)c3F)cc12 CHEMBL1979970 pKi 63.1 nM
CS(=O)(=O)NCCNc1cc(-c2c[nH]c3ncccc23)cc(Cl)n1 CHEMBL2005718 pKi 63.1 nM
O=C(O)c1ccccc1Nc1ccnc(Nc2ccc([N+](=O)[O-])cc2)n1 CHEMBL242865 pKi 63.1 nM
NC(=O)c1cccc(-c2cnc3[nH]cc(-c4ccccc4)c3c2)c1 CHEMBL1982957 pKi 63.1 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4c[nH]c5ccccc45)c3)cc12 CHEMBL1970903 pKi 63.1 nM
CNS(=O)(=O)c1ccccc1Nc1nc(Nc2cc(N3CCN(C(C)=O)CC3)ccc2OC)ncc1Br CHEMBL1971029 pKi 63.1 nM
CC(C)c1cnc(NC(=O)Cc2ccccc2)s1 CHEMBL426972 IC50 64.0 nM
O=C(Cc1ccccc1)Nc1ncc(C2CCCC2)s1 CHEMBL186511 IC50 64.0 nM
COc1ccc2c(c1)/C(=C/c1cnc[nH]1)C(=O)N2 CHEMBL258805 IC50 65.0 nM
CC[C@H](Nc1nc(NCc2cccnc2)c2ncn(C(C)C)c2n1)[C@@H](C)O CHEMBL1922219 IC50 70.0 nM
O=C1Nc2ccccc2CN1c1csc(-c2ccncc2)n1 CHEMBL240799 IC50 79.0 nM
O=C1NC(=O)C(c2cn3c4c(cc(F)cc24)CN(C(=O)N2CCCCC2)CC3)=C1c1cn2ccccc2n1 CHEMBL5178166 IC50 79.0 nM
O=C(O)c1ccccc1Nc1ccnc(Nc2ccc3cn[nH]c3c2)n1 CHEMBL244378 pKi 79.43 nM
CN1c2ccc(N)cc2C(c2ccccc2)c2cc(N)ccc21 CHEMBL1991734 pKi 79.43 nM
NC(COc1cncc(-c2ccc3cnccc3c2)c1)Cc1c[nH]c2ccccc12 CHEMBL1981133 pKi 79.43 nM
NS(=O)(=O)c1cccc(Nc2ncc3ccn(Cc4ccccc4)c3n2)c1 CHEMBL1993424 pKi 79.43 nM
COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 CHEMBL509032 pKi 79.43 nM
CCC(CO)Nc1nc(Nc2cccc(-c3ccccn3)c2)c2ncn(C(C)C)c2n1 CHEMBL1080583 IC50 80.0 nM
O=C1Nc2cc(Br)ccc2/C1=C1/Nc2ccccc2/C1=N\O CHEMBL409450 IC50 83.0 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL388978 Kd 84.0 nM
CSc1cnc(NC(=O)Cc2ccccc2)s1 CHEMBL185734 IC50 91.0 nM
O=C(Nc1cnccn1)Nc1ccnc2c(F)cccc12 CHEMBL1975647 pKi 100.0 nM
O=C1Nc2ccccc2C1=Cc1ccc[nH]1 CHEMBL1996176 pKi 100.0 nM
Cc1n[nH]c2ccc(-c3cncc(OCCN)c3)cc12 CHEMBL1967887 pKi 100.0 nM
CC(C)(C)Nc1ncnc2[nH]cc(-c3ccccc3)c12 CHEMBL1995211 pKi 100.0 nM
CN1CCN(c2ccc(Nc3ncc(Cl)c(Nc4ccc5[nH]ncc5c4)n3)cc2)CC1 CHEMBL1979690 pKi 100.0 nM
CS(=O)(=O)NC1CCCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)C1 CHEMBL1987948 pKi 100.0 nM
COc1cc(-c2ccc3c(c2)Nc2ccc(C(=O)NCCNC(C)=O)cc2NC3=O)ccc1O CHEMBL1975500 pKi 100.0 nM
CSc1cnc2c(ccc3cnccc32)c1O CHEMBL2006933 pKi 100.0 nM
C#Cc1cn(C2CCCC2)c2ncnc(N)c12 CHEMBL1993877 pKi 100.0 nM
CN(C)CC(=O)Nc1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12 CHEMBL1965631 pKi 100.0 nM
CC(C)c1cnc(NC(=O)Nc2ccccc2)s1 CHEMBL186510 IC50 102.0 nM
O=C(Cc1ccc2ccccc2c1)Nc1cc(C2CC2)n[nH]1 CHEMBL115220 IC50 114.0 nM
CC(C)c1n[nH]c2c(NCc3ccc(-c4ccccn4)cc3)nc(N3CCSCC3)nc12 CHEMBL3775681 IC50 114.0 nM
CC(C)c1n[nH]c2c(NCc3ccc(-c4ccccn4)cc3)nc(N3CCNCC3)nc12 CHEMBL3774949 IC50 119.0 nM
Cc1ccnc2[nH]c3cc(C(C)C)ccc3c(=O)c12 CHEMBL1989471 pKi 125.89 nM
CCCC(=O)Nc1cc(-c2c[nH]c3ncccc23)cc(Cl)n1 CHEMBL1998470 pKi 125.89 nM
NC1CCCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)C1 CHEMBL1998432 pKi 125.89 nM
COc1ccc(-c2cc3nccn3c(Nc3ncccc3C(N)=O)n2)cc1OC CHEMBL1190711 pKi 125.89 nM
NC(=O)c1ccc2nc(-c3ccc([N+](=O)[O-])o3)cn2c1 CHEMBL1973359 pKi 125.89 nM
Cc1n[nH]c2ccc(-c3cccnc3)cc12 CHEMBL1967252 pKi 125.89 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(CN)Cc4ccccc4)c3)cc12 CHEMBL2000271 pKi 125.89 nM
Clc1cc(-c2c[nH]c3ncccc23)nc(NC2CCCCC2)n1 CHEMBL2006439 pKi 125.89 nM
COc1ccccc1CNC(=N)Nc1nccc(-c2cccs2)n1 CHEMBL1997197 pKi 125.89 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4ccccc4)c3)cc12 CHEMBL2002726 pKi 125.89 nM
NC(=O)c1cc2c(-c3ccc(F)cc3F)cncc2s1 CHEMBL1975787 pKi 125.89 nM
CCCNC(=O)c1ccc(Nc2nc(NCC(F)(F)F)c3cc[nH]c3n2)cc1 CHEMBL2006765 pKi 125.89 nM
CCOC(=O)c1cc(-c2csc(-c3ccncc3)n2)c(=O)[nH]c1C CHEMBL577030 IC50 131.0 nM
CN(C)C/C=C/C(=O)Nc1cccc(C(=O)Nc2cccc(Nc3ncc(Cl)c(-c4c[nH]c5ccccc45)n3)c2)c1 CHEMBL4303287 IC50 134.0 nM
S=C(Nc1cccc(Cl)c1)N1CCN(c2nnc(Cc3ccccc3)c3ccccc23)CC1 CHEMBL5426122 IC50 135.22 nM
COc1ccc(Cc2nnc(N3CCN(C(=O)Nc4ccc(OC)cc4)CC3)c3ccccc23)cc1 CHEMBL5440832 IC50 140.33 nM
Cc1nc(Nc2nc3ccc(-c4cccc(C(=O)Nc5cccc(C(F)(F)F)c5)c4)nc3s2)cc(N2CCNCC2)n1 CHEMBL2148120 Kd 150.0 nM
OCCNc1cc2cc(-c3cccnc3)ccc2cn1 CHEMBL1990912 pKi 158.49 nM
O=C(Nc1cnccn1)Nc1ccnc2ccccc12 CHEMBL1981720 pKi 158.49 nM
COc1cc(OC)cc(C(=O)Nc2n[nH]c3ccc(-c4cn(Cc5ccccc5)nn4)cc23)c1 CHEMBL2002613 pKi 158.49 nM
Brc1ccc2cnc(Nc3ccncn3)cc2c1 CHEMBL1984686 pKi 158.49 nM
NC(=O)c1cc2c(-c3ccccc3)cncc2s1 CHEMBL1999556 pKi 158.49 nM
CCCn1c(C2CCNCC2)nc(-c2ccc(Cl)c(Cl)c2)c1-c1ccnc(NC2CCCCC2)n1 CHEMBL437747 pKi 158.49 nM
CC(C)(CN)CNc1cc(-c2c[nH]c3ncccc23)cc(F)n1 CHEMBL1987261 pKi 158.49 nM
Cc1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3-c3ccc(F)cc3)cc12 CHEMBL1972339 pKi 158.49 nM
O=C(NCCc1cccs1)N1CC=C(c2c[nH]c3ncccc23)CC1 CHEMBL1987535 pKi 158.49 nM
O=C(O)c1ccccc1Nc1ccnc(Nc2ccc3[nH]ncc3c2)n1 CHEMBL396523 pKi 158.49 nM
COc1cc2c(cc1F)C(c1ccccc1Cl)=Nc1c(n[nH]c1C)N2 CHEMBL1980391 pKi 158.49 nM
O=C(Nc1ccccc1)N1CCN(c2nnc(Cc3ccccc3)c3ccccc23)CC1 CHEMBL5398705 IC50 158.73 nM
CC(C)n1cnc2c(NCc3cccc(I)c3)nc(N3CCC[C@@H]3CO)nc21 CHEMBL3085252 IC50 160.0 nM
CCC(CO)Nc1nc(NCc2ccccc2)c2ncn(C(C)C)c2n1 CHEMBL52387 IC50 160.0 nM
CC(C)c1n[nH]c2c(NCc3ccc(-c4ccccn4)cc3)nc(S(C)(=O)=O)nc12 CHEMBL3775606 IC50 165.0 nM
CC(C)c1n[nH]c2c(NCc3ccc(-c4ccccn4)cc3)nc(N[C@H]3CC[C@H](N)CC3)nc12 CHEMBL3774503 IC50 179.0 nM
O=C(Nc1ccccc1)Nc1ncc(C2CCC2)s1 CHEMBL185470 IC50 183.0 nM
CC(C)c1n[nH]c2c(NCc3ccc(-c4ccccn4)cc3)ncnc12 CHEMBL3774434 IC50 183.0 nM
O=C(Nc1ncc(C2CCC2)s1)Nc1cccc2c[nH]nc12 CHEMBL363283 IC50 190.0 nM
CCc1c(-c2ccc(C(C)=O)cc2)[nH]c2nccnc12 CHEMBL1994555 pKi 199.53 nM
OCC(CO)Nc1ncnc2[nH]cc(-c3ccccc3)c12 CHEMBL1992922 pKi 199.53 nM
O=C1NCCc2[nH]c(-c3ccncc3)cc21 CHEMBL225519 pKi 199.53 nM
NC(COc1cncc(-c2ccc3c(c2)C(=Cc2ccco2)C(=O)N3)c1)Cc1c[nH]c2ccccc12 CHEMBL2001751 pKi 199.53 nM
CCN1CCN(c2ccc(Nc3ncc(Cl)c(Nc4ccc5[nH]ncc5c4)n3)cc2)CC1 CHEMBL1967998 pKi 199.53 nM
CNC(=O)COc1ccc(Nc2nc(Nc3ccc(C)c(S(N)(=O)=O)c3)ncc2F)cc1 CHEMBL1978099 pKi 199.53 nM
O=C(Nc1cccc(C(F)(F)F)n1)Nc1ccnc2c(F)cccc12 CHEMBL1966816 pKi 199.53 nM
O=C(Nc1cnccn1)Nc1ccnc2c(F)cc(F)cc12 CHEMBL1967336 pKi 199.53 nM
CC(=O)NC1CCCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)C1 CHEMBL1980178 pKi 199.53 nM
Cc1nc(N)sc1-c1ccnc(Nc2ccc(N3CCOCC3)cc2)n1 CHEMBL482967 pKi 199.53 nM
NCCn1cc(-c2cc(-c3cc4ccccc4s3)c3[nH]ncc3c2)c2nc(N)ncc21 CHEMBL590109 pKi 199.53 nM
CN1C(=O)/C(=C2\Nc3ccc(C(=O)O)cc3\C2=N/O)c2cccc(Br)c21 CHEMBL2321958 IC50 200.0 nM
O=C1Nc2c(Br)cccc2/C1=C1/Nc2ccc(/C=N/O)cc2C1=O CHEMBL2321948 IC50 200.0 nM
CC[C@@H](CO)Nc1nc(NCc2ccccc2)c2ncn(C(C)C)c2n1 CHEMBL133342 IC50 200.0 nM
CN1CC[C@@H](c2c(O)cc(O)c3c(=O)cc(-c4ccc(C(F)(F)F)cc4Cl)oc23)[C@@H]1CO CHEMBL3905910 IC50 210.0 nM
CC[C@H](CO)Nc1nc(NCc2ccc(-c3ccccn3)cc2)c2ncn(C(C)C)c2n1 CHEMBL518800 IC50 225.0 nM
CSc1nc(NCc2ccc(-c3ccccn3)cc2)c2[nH]nc(C(C)C)c2n1 CHEMBL3775479 IC50 229.0 nM
CCC(C)(O)C#Cc1nc(NCc2ccc(Cl)cc2)c2ncn(C(C)C)c2n1 CHEMBL24484 IC50 230.0 nM
O=C1CCC(N2C(=O)c3cccc(OCCCCCOc4ccc(CC(=O)Nc5cc(C6CCC6)[nH]n5)cc4)c3C2=O)C(=O)N1 CHEMBL4519788 Kd 230.0 nM
Cc1cc(C)c(CNc2nc(N[C@@H](C)[C@@H](C)O)nc3c2ncn3C(C)C)cn1 CHEMBL4579344 IC50 232.0 nM
CN(C)C1CCCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)C1 CHEMBL1965702 pKi 251.19 nM
O=C1Nc2ccccc2Nc2nnc(I)cc21 CHEMBL1977346 pKi 251.19 nM
O=C(O)c1ccccc1Nc1ncnc(Nc2ccc3cn[nH]c3c2)n1 CHEMBL1986666 pKi 251.19 nM
O=C(Nc1cnccn1)Nc1ccnc2ccc(C(F)(F)F)cc12 CHEMBL1976455 pKi 251.19 nM
COc1ccc(C2=NNc3cccc4c(OC)ccc2c34)cc1OC CHEMBL1997335 pKi 251.19 nM
NC(=O)c1cc2c(-c3ccc(F)cc3)cncc2s1 CHEMBL1974310 pKi 251.19 nM
CCN1CCN(c2ccc(Nc3ncc(C#N)c(Nc4ccc5[nH]ncc5c4)n3)cc2)CC1 CHEMBL1973516 pKi 251.19 nM
Brc1cnc2[nH]cc(-c3ccccc3)c2c1 CHEMBL1992634 pKi 251.19 nM
CCCCOc1ncnc2[nH]cc(-c3ccccc3)c12 CHEMBL1996817 pKi 251.19 nM
CC(=O)c1cnc2ccc(-c3cc(Cl)c(O)c(Cl)c3)nc2c1N[C@H]1CC[C@H](CN(C)C)CC1 CHEMBL3688339 Kd apparent 253.0 nM
CCC(C)(O)C#Cc1nc(NCc2ccc(N(C)C)cc2)c2ncn(C(C)C)c2n1 CHEMBL23525 IC50 260.0 nM
O=C(c1ccccc1)N1CCN(c2nnc(Cc3ccccc3)c3ccccc23)CC1 CHEMBL5424761 IC50 275.75 nM
COc1ccc(NC(=O)N2CCN(c3nnc(Cc4ccccc4)c4ccccc34)CC2)cc1 CHEMBL5438882 IC50 280.33 nM
CCC(C)(O)C#Cc1nc(NCc2ccc3c(c2)OCO3)c2ncn(C(C)C)c2n1 CHEMBL286491 IC50 300.0 nM
CCC(C)(O)C#Cc1nc(Nc2ccccc2)c2ncn(C(C)C)c2n1 CHEMBL284899 IC50 300.0 nM
CCC(C)(O)C#Cc1nc(Nc2ccc(OC)cc2)c2ncn(C(C)C)c2n1 CHEMBL23317 IC50 300.0 nM
CC1(COc2ccc3c(c2)ncn3-c2ccc3cccc(N4CCC(N)CC4)c3n2)COC1 CHEMBL2105728 Kd apparent 313.0 nM
CC(C)(CNc1cc(-c2c[nH]c3ncccc23)cc(Cl)n1)CNS(C)(=O)=O CHEMBL1971172 pKi 316.23 nM
OCc1cc(-c2ccc3[nH]ncc3c2)on1 CHEMBL1974617 pKi 316.23 nM
NC(=O)c1cc(-c2ccnc(N)n2)[nH]c1-c1ccc(Cl)cc1Cl CHEMBL1965660 pKi 316.23 nM
Cc1ccc2nccc(NC(=O)Nc3cccc(C(F)(F)F)n3)c2c1 CHEMBL1964444 pKi 316.23 nM
Cc1cc(Cl)ccc1NC(=S)NNC(=O)C(O)(c1ccccc1)c1ccccc1 CHEMBL1988173 pKi 316.23 nM
c1ccc(Cn2nnc(-c3ccc4[nH]ncc4c3)c2C2CC2)cc1 CHEMBL1975418 pKi 316.23 nM
OC1CCN(c2ncnc3[nH]cc(-c4ccccc4)c23)CC1 CHEMBL1973395 pKi 316.23 nM
Cc1cc(Nc2ncc(F)c(NC3C4C=CC(C4)C3C(N)=O)n2)ccc1N1CCN(C)CC1 CHEMBL1967878 pKi 316.23 nM
O=C(NN=Cc1cc(Br)c(O)c(Br)c1)Nc1ccccc1 CHEMBL1983575 pKi 316.23 nM
Cc1ccc(Nc2nc3ccc([N+](=O)[O-])cc3[nH]2)nc1 CHEMBL1992937 pKi 316.23 nM
NC(COc1cncc(-c2cc3ccncc3s2)c1)Cc1c[nH]c2ccccc12 CHEMBL1966524 pKi 316.23 nM
CC(C)(CN)CNc1cc(-c2c[nH]c3ncccc23)cc(Cl)n1 CHEMBL1985723 pKi 316.23 nM
CCC(=O)Nc1ccc(C(=O)N2CCNCC2)c(O)c1 CHEMBL1988141 pKi 316.23 nM
CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCNCC4)cn3)nc2n(C2CCCC2)c1=O CHEMBL189963 pKi 316.23 nM
CC(=NNC(=N)N)c1cc(NC(=O)c2cccc(C(=O)Nc3cc(C(C)=NNC(=N)N)cc(C(C)=NNC(=N)N)c3)c2)cc(C(C)=NNC(=N)N)c1 CHEMBL2000685 pKi 316.23 nM
COc1ccc(-c2cnc3c(Br)cnn3c2)cc1 CHEMBL443962 pKi 316.23 nM
Cc1cccc(Nc2nc(NC3CCCCC3N)cnc2C(N)=O)c1 CHEMBL1974328 pKi 316.23 nM
O=C(Cc1ccc(-c2cccnc2)cc1)Nc1ccc(SC(F)F)cc1 CHEMBL1992581 pKi 316.23 nM
COCCN1CCN(Cc2ccc(-c3n[nH]c4c3C(=O)c3c(NC(=O)NN5CCOCC5)cccc3-4)cc2)CC1 CHEMBL3545083 Kd apparent 318.0 nM
CC(C)C(=O)Nc1ncc(C(C)C)s1 CHEMBL363711 IC50 321.0 nM
CCC(C)(O)C#Cc1nc(NCc2ccccc2)c2ncn(C(C)C)c2n1 CHEMBL26564 IC50 340.0 nM
CCCCNc1nc(C#CC(C)(O)Cc2ccccc2)nc2c1ncn2C(C)C CHEMBL133461 IC50 340.0 nM
COc1ccc(Cc2nnc(N3CCN(C(=S)Nc4cccc(Cl)c4)CC3)c3ccccc23)cc1 CHEMBL5411187 IC50 354.15 nM
S=C(Nc1ccc(Cl)cc1)N1CCN(c2nnc(Cc3ccccc3)c3ccccc23)CC1 CHEMBL5418073 IC50 358.47 nM
COc1ccc(Cc2nnc(N3CCN(C(=O)Nc4ccc(Cl)c(C(F)(F)F)c4)CC3)c3ccccc23)cc1 CHEMBL5409788 IC50 369.37 nM
O=C(Cc1ccccc1)Nc1ncc(C2CCCCC2)s1 CHEMBL186846 IC50 390.0 nM
Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(OCCN3CCOCC3)c3ccccc23)cc1 CHEMBL103667 Kd 390.0 nM
COc1ccc(Cc2nnc(N3CCN(C(=O)c4ccccc4)CC3)c3ccccc23)cc1 CHEMBL5404411 IC50 391.03 nM
Cc1ccnc(Nc2cc(C)nc(-c3ccccc3)n2)c1 CHEMBL1985367 pKi 398.11 nM
OCCCNc1ncnc2[nH]cc(-c3ccccc3)c12 CHEMBL2000071 pKi 398.11 nM
CC(C)(C)c1ccc2nc(-c3n[nH]c4ccccc34)[nH]c2c1 CHEMBL1970104 pKi 398.11 nM
Cc1cnc(Nc2cccc(S(N)(=O)=O)c2)nc1Nc1ccc(OCC(N)=O)cc1 CHEMBL1988838 pKi 398.11 nM
CC(C)C(C)Nc1ncc(Cl)c(Nc2nccs2)n1 CHEMBL1993374 pKi 398.11 nM
O=C(O)c1ccccc1Nc1ccnc(Nc2cccc(O)c2)n1 CHEMBL243088 pKi 398.11 nM
CCCC(=O)Nc1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3-c3ccccc3)cc12 CHEMBL2005936 pKi 398.11 nM
NC1CCC(Nc2cc(Cl)nc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1983589 pKi 398.11 nM
Nc1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3-c3ccccc3)cc12 CHEMBL1972158 pKi 398.11 nM
N#Cc1ccc(-c2ccncc2)cc1NCc1ccccc1 CHEMBL1967992 pKi 398.11 nM
CCCS(=O)(=O)Nc1ccc(-c2ccc3[nH]nc(NC(=O)CC)c3c2)cc1 CHEMBL1972221 pKi 398.11 nM
COCC#Cc1cccc2c1Cc1c(-c3cccs3)n[nH]c1-2 CHEMBL1985206 pKi 398.11 nM
C=CCc1cccc2c(=NO)cc(-c3ccccc3)oc12 CHEMBL1977749 pKi 398.11 nM
CS(=O)(=O)NC1CCC(Nc2cc(Cl)nc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL2005216 pKi 398.11 nM
CCCc1cc(-c2ccc3[nH]ncc3c2)on1 CHEMBL1682359 pKi 398.11 nM
O=C1Nc2ccccc2Nc2nnc(Cl)cc21 CHEMBL1968850 pKi 398.11 nM
O=C1NC(=O)c2c1c(-c1ccccc1Cl)cc1[nH]c3ccc(O)cc3c21 CHEMBL379975 pKi 398.11 nM
N#Cc1ccc2[nH]c(O)c(-c3ccc(CN4CCOCC4)cn3)c2c1 CHEMBL1969664 pKi 398.11 nM
NCc1cc(Nc2ncnc(-c3ccccc3)n2)ccc1O CHEMBL1980246 pKi 398.11 nM
CCOc1ccc(Nc2nc(C#CC(C)(O)CC)nc3c2ncn3C(C)C)cc1 CHEMBL280623 IC50 400.0 nM
CCCC(CO)Nc1nc(NCc2ccccc2)c2ncn(C(C)C)c2n1 CHEMBL131697 IC50 400.0 nM
CCC(C)(O)C#Cc1nc(NCc2ccc(OC)cc2)c2ncn(C(C)C)c2n1 CHEMBL422759 IC50 400.0 nM
O=C1Nc2c(Br)cccc2/C1=C1/Nc2ccc(CO)cc2/C1=N\O CHEMBL2321964 IC50 400.0 nM
O=C(Nc1ccc(Cl)c(C(F)(F)F)c1)N1CCN(c2nnc(Cc3ccccc3)c3ccccc23)CC1 CHEMBL5414410 IC50 404.87 nM
C[C@]12O[C@H](C[C@]1(O)CO)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)CNC4=O CHEMBL603469 Kd 410.0 nM
CC(C)(C)Nc1c(Nc2ccnc(Nc3ccc(-c4ccncc4)cc3)n2)c(=O)c1=O CHEMBL2205426 Ki 416.0 nM
CC(C)c1n[nH]c2c(NCc3ccc(-c4ccccn4)cc3)nc(N3CCN(CCO)CC3)nc12 CHEMBL3775467 IC50 422.0 nM
COc1ccc(Cc2nnc(N3CCN(C(=S)Nc4ccc(OC)cc4)CC3)c3ccccc23)cc1 CHEMBL5431456 IC50 452.49 nM
NS(=O)(=O)c1ccc(Nc2nc(OCC3CCCCC3)c3nc[nH]c3n2)cc1 CHEMBL319467 IC50 480.0 nM
COc1ccc(NC(=S)N2CCN(c3nnc(Cc4ccccc4)c4ccccc34)CC2)cc1 CHEMBL5424372 IC50 498.0 nM
CCC(C)(O)C#Cc1nc(Nc2ccc(Cl)c(Cl)c2)c2ncn(C(C)C)c2n1 CHEMBL26513 IC50 500.0 nM
OC[C@H]1CCCN1c1nc(NCc2ccccc2)c2ncn(C3CCCC3)c2n1 CHEMBL3085251 IC50 500.0 nM
CCC(C)(O)C#Cc1nc(Nc2cccc(Cl)c2)c2ncn(C(C)C)c2n1 CHEMBL282193 IC50 500.0 nM
CCC(C)(O)C#Cc1nc(NCc2ccc(Cl)c(Cl)c2)c2ncn(C(C)C)c2n1 CHEMBL25840 IC50 500.0 nM
Oc1cnc2ccc(-c3ccncc3)cc2c1 CHEMBL1973868 pKi 501.19 nM
COc1ccccc1-c1ccnc(Nc2cccc(S(C)(=O)=O)c2)n1 CHEMBL1975903 pKi 501.19 nM
NC(=O)c1cc2c(-c3ccc(Nc4nc5ccccc5o4)cc3)cnc(N)c2s1 CHEMBL1993904 pKi 501.19 nM
CCCS(=O)(=O)Nc1ccc(-c2ccc3[nH]nc(NC(C)=O)c3c2)cc1 CHEMBL1973893 pKi 501.19 nM
NC(=O)c1ccc(-c2c[nH]c3nccc(Cl)c23)cc1 CHEMBL1982711 pKi 501.19 nM
CCN(C(C)=O)c1ccc(Nc2nc(NC3CC3)c3nc[nH]c3n2)cc1 CHEMBL2006564 pKi 501.19 nM
Cc1c(-c2ccc3[nH]nc(N)c3c2)nnn1Cc1ccccc1 CHEMBL1989646 pKi 501.19 nM
CS(=O)(=O)c1ccc(-c2cncc3sc(C(N)=O)cc23)cc1 CHEMBL1972362 pKi 501.19 nM
Nc1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3-c3ccc(F)cc3)cc12 CHEMBL1986499 pKi 501.19 nM
O=C(O)c1ccc2c(c1)nc(Nc1cccc(Cl)c1)c1ccncc12 CHEMBL1230165 Kd apparent 514.0 nM
COC(=O)c1ccc2c(c1)C(=N\O)/C(=C1/C(=O)Nc3ccccc31)N2 CHEMBL2321951 IC50 520.0 nM
O=C1Nc2ccccc2/C1=C1/Nc2ccc(C(=O)O)cc2/C1=N\O CHEMBL2321952 IC50 530.0 nM
CCN1CCN(Cc2ccc(NC(=O)Nc3ccc(Oc4cc(NC)ncn4)cc3)cc2C(F)(F)F)CC1 CHEMBL574738 Kd 550.0 nM
CCC(C)(O)C#Cc1nc(NCc2ccc(OC)c(OC)c2)c2ncn(C(C)C)c2n1 CHEMBL281525 IC50 600.0 nM
O=C1Nc2c(Br)cccc2/C1=C1/Nc2ccc(/C=N\O)cc2/C1=N\O CHEMBL2321965 IC50 600.0 nM
COc1ccc(Cc2nnc(N3CCN(C(=O)Nc4ccccc4)CC3)c3ccccc23)cc1 CHEMBL5417190 IC50 601.3 nM
COc1ccc(C(=O)N2CCN(c3nnc(Cc4ccccc4)c4ccccc34)CC2)cc1 CHEMBL5417371 IC50 605.65 nM
CCc1cnc(NC(=O)Cc2ccccc2)s1 CHEMBL185498 IC50 621.0 nM
Cc1ncc(-c2ccnc(Nc3ccc(S(C)(=O)=O)cc3)n2)n1C(C)C CHEMBL488436 Kd apparent 627.0 nM
C=CCn1c(=O)c2cnc(Nc3ccc(N4CCN(C)CC4)cc3)nc2n1-c1cccc(C(C)(C)O)n1 CHEMBL1976040 pKi 630.96 nM
Nc1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3I)cc12 CHEMBL1975128 pKi 630.96 nM
NC(=O)c1cc2c(Oc3ccc(Br)cc3)cncc2s1 CHEMBL116070 pKi 630.96 nM
COc1ccc(C=NNc2ncnc3c2[nH]c2ccccc23)cc1OC CHEMBL1974664 pKi 630.96 nM
COc1cccc(C(C)NC(=O)N2CC=C(c3c[nH]c4ncccc34)CC2)c1 CHEMBL1965845 pKi 630.96 nM
CC(C)Nc1c(-c2ccc3[nH]ncc3c2)nc2ncccn12 CHEMBL1682553 pKi 630.96 nM
Cc1cc(C(N)=O)n2nc(C(C)(C)C)cc2n1 CHEMBL1986684 pKi 630.96 nM
CN(C)CC(=O)NC1CCCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)C1 CHEMBL1995712 pKi 630.96 nM
O=C(O)c1ccccc1Nc1ncnc(Nc2cccc(F)c2)n1 CHEMBL1979933 pKi 630.96 nM
CSc1ncc2c(n1)CCc1cnc(Nc3ccc(C(=O)N(C)CCN(C)C)cc3)nc1-2 CHEMBL4294760 IC50 680.0 nM
O=C(Nc1cnccc1-c1ccc(F)cc1)c1ccnc(Nc2ccc(F)cc2)n1 CHEMBL5402829 IC50 680.0 nM
CC(C)n1cnc2c(NCc3ccccc3)nc(N[C@H](C)CO)nc21 CHEMBL2112678 IC50 700.0 nM
COc1cccc(NC(=S)N2CCN(c3nnc(Cc4ccccc4)c4ccccc34)CC2)c1 CHEMBL5436482 IC50 705.0 nM
COc1ccc(Cc2nnc(N3CCN(C(=S)Nc4ccc(Cl)cc4)CC3)c3ccccc23)cc1 CHEMBL5436647 IC50 716.28 nM
O=c1oc2cc(O)ccc2c2c1[nH]c1ccc(O)cc12 CHEMBL1946917 IC50 720.0 nM
CCc1nc2c(c3cc(OC)c(OC)cc13)C(=O)NC2=O CHEMBL2003524 pKi 794.33 nM
O=c1cc(-c2ccncc2)nc(NC2CCCCC2)[nH]1 CHEMBL1958401 pKi 794.33 nM
COc1ccc(Nc2nccc(Nc3c(NC(C)C(C)(C)C)c(=O)c3=O)n2)cc1OC CHEMBL1964399 pKi 794.33 nM
Nc1cc(Nc2ccc(O)c(CNC(=O)C(F)(F)F)c2)ncn1 CHEMBL2002418 pKi 794.33 nM
O=C(O)c1ccccc1Nc1ccnc(Nc2cccc(F)c2)n1 CHEMBL243298 pKi 794.33 nM
COc1cc(-c2csc3c(C=CC(=O)NCCN(C)C)cnc(N)c23)ccc1NC(=O)c1cc2ccccc2n1C CHEMBL1989267 pKi 794.33 nM
NC(=O)Cn1cc(-c2cc(-c3cc4ccccc4s3)c3[nH]ncc3c2)c2nc(N)ncc21 CHEMBL1985095 pKi 794.33 nM
c1ccc(Cn2cc(-c3ccc4[nH]ncc4c3)nn2)cc1 CHEMBL1682345 pKi 794.33 nM
O=C1NC(=O)C(c2c[nH]c3ccccc23)=C1c1nc(N2CCNCC2)nc2ccccc12 CHEMBL1996510 pKi 794.33 nM
COc1ccc(C(=O)N2c3ccccc3Sc3c(Cl)cncc32)cc1 CHEMBL1988537 pKi 794.33 nM
NC(=O)c1cc2ccncc2s1 CHEMBL1971534 pKi 794.33 nM
O=C(NNC(=S)Nc1ccc(Cl)cc1)C(O)(c1ccccc1)c1ccccc1 CHEMBL1966722 pKi 794.33 nM
O=C(Nc1cnccn1)Nc1ccnc2c(C(F)(F)F)cccc12 CHEMBL1994538 pKi 794.33 nM
COc1c(-c2nc3ccccc3[nH]2)c(O)cc2oc(C)cc(=O)c12 CHEMBL1972355 pKi 794.33 nM
O=C(Nc1ccc(Cl)cc1)N1CCN(c2nnc(Cc3ccccc3)c3ccccc23)CC1 CHEMBL5431565 IC50 826.47 nM
O=C(c1ccc(Cl)cc1)N1CCN(c2nnc(Cc3ccccc3)c3ccccc23)CC1 CHEMBL5423237 IC50 834.55 nM
O=C(Cc1ccccc1)Nc1ncc(Br)s1 CHEMBL186201 IC50 900.0 nM
Cc1ccc(-c2ccc3c(ccc4sc5c(c43)NC[C@@H](C)NC5=O)n2)cn1 CHEMBL1231206 IC50 902.0 nM
COC(=O)[C@@]1(O)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL281948 Kd apparent 911.0 nM
S=C(Nc1ccccc1)N1CCN(c2nnc(Cc3ccccc3)c3ccccc23)CC1 CHEMBL5407116 IC50 947.33 nM
COc1ccc(Cc2nnc(N3CCN(C(=S)Nc4ccccc4)CC3)c3ccccc23)cc1 CHEMBL5396190 IC50 995.67 nM
CCCCC(=O)Nc1cc(-c2c[nH]c3ncccc23)cc(Cl)n1 CHEMBL2006450 pKi 1000.0 nM
Nc1ncnc2c1sc1ncnc(N)c12 CHEMBL1976090 pKi 1000.0 nM
O=C(NNC(=S)Nc1ccc(F)cc1)C(O)(c1ccccc1)c1ccccc1 CHEMBL1975138 pKi 1000.0 nM
CC(C)NC1=NNC(=O)C1=Cc1cc2ccccc2[nH]1 CHEMBL1988692 pKi 1000.0 nM
Cc1ccc(C)c(NC(=O)c2cc(-c3ccco3)nc3ccccc23)c1 CHEMBL1984296 pKi 1000.0 nM
CC(C)Cc1cc(-c2ccc3[nH]nc(N)c3c2)on1 CHEMBL1966343 pKi 1000.0 nM
Nc1n[nH]c2ncc(Br)cc12 CHEMBL2002105 pKi 1000.0 nM
NC(=O)c1cccc2c1Nc1nnc(Cl)cc1C(=O)N2 CHEMBL1968070 pKi 1000.0 nM
COc1cc2cnc3c(c2cc1OC)C(=O)NC3=O CHEMBL1982506 pKi 1000.0 nM
Oc1c2ccccc2c2c3c(cccc13)N=N2 CHEMBL1725279 pKi 1000.0 nM
O=C1Nc2ccccc2C1=Cc1c[nH]c2ccccc12 CHEMBL1986590 pKi 1000.0 nM
CCCC(=O)Nc1nn(C(=O)CC)c2nc3ccccc3cc12 CHEMBL1970913 pKi 1000.0 nM
COc1cccc(C(C)NC(=O)c2cc(C)c(-c3ccc4[nH]nc(C)c4c3)s2)c1 CHEMBL1997534 pKi 1000.0 nM
Clc1cc(-c2c[nH]c3ncccc23)ncn1 CHEMBL1972988 pKi 1000.0 nM
CCS(=O)(=O)c1ccc(-c2cncc3sc(C(N)=O)cc23)cc1 CHEMBL2000104 pKi 1000.0 nM
Cc1n[nH]c2ncc(C#N)c(-c3ccccc3)c12 CHEMBL1965495 pKi 1000.0 nM
CN(C)CCCC(=O)Nc1n[nH]c2nnc(-c3cccc(F)c3F)cc12 CHEMBL41783 pKi 1000.0 nM
CCCNC(=O)c1ccc(Nc2nc(CCC(F)(F)F)c3cc[nH]c3n2)cc1 CHEMBL1984760 pKi 1000.0 nM
CN1C(=O)[C@@H](N2CCc3cn(Cc4ccccc4)nc3C2=O)COc2ccccc21 CHEMBL4088216 pIC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3c(nn(Cc4ccccc4)c3Br)C2=O)COc2ccccc21 CHEMBL4549667 pIC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3cn(CC4CCS(=O)(=O)CC4)nc3C2=O)COc2ccccc21 CHEMBL4097778 pIC50 1000.0 nM