C[C@@]1(O)CCC[C@H]1n1c(=O)c(C(F)F)cc2cnc(NC3CCN(S(C)(=O)=O)CC3)nc21 CHEMBL4446357 Ki 0.16 nM
c1ccc(-n2c3cnccc3c3cnc(Nc4ccc(N5CCNCC5)cc4)nc32)cc1 CHEMBL3698653 IC50 0.36 nM
c1ccc2c(c1)c1cnc(Nc3ccc(N4CCNCC4)cc3)nc1n2C1CCCCC1 CHEMBL3698657 IC50 0.41 nM
c1ccc2c(c1)c1cnc(Nc3ccc(N4CCNCC4)cc3)nc1n2C1CCOCC1 CHEMBL3698681 IC50 0.75 nM
CCN1CCN(Cc2ccc(Nc3ncc(F)c(-c4cc(F)c5nc6n(c5c4)C(C)(C)CC6)n3)nc2)CC1 CHEMBL4208172 IC50 0.9 nM
CC1(C)CCC(n2c3cnccc3c3cnc(Nc4ccc(N5CCNCC5)cn4)nc32)CC1 CHEMBL3237704 IC50 1.1 nM
c1cc2c3cnc(Nc4cnc(N5CCNCC5)nc4)nc3n(C3CCCC3)c2cn1 CHEMBL3698644 IC50 1.1 nM
c1ccc2c(c1)c1cnc(Nc3ccc(N4CCNCC4)cn3)nc1n2C1CCCC1 CHEMBL3698672 IC50 1.2 nM
c1cc2c3cnc(Nc4ccc(N5CCNCC5)nc4)nc3n(C3CCCC3)c2cn1 CHEMBL3698643 IC50 1.3 nM
O[C@@H]1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)C1 CHEMBL3698654 IC50 1.5 nM
CCN1CCN(Cc2cnc(Nc3cc(-c4cc(F)c5nc(C)n(C(C)C)c5c4)ccn3)cn2)CC1 CHEMBL4204030 IC50 1.6 nM
CCN1CCN(Cc2cnc(Nc3cc(-c4cc(F)c5nc(C)n(C(C)C)c5c4)c(F)cn3)cn2)CC1 CHEMBL4218267 IC50 1.6 nM
COCCN1CCN(Cc2cnc(Nc3cc(-c4cc(F)c5nc(C)n(C(C)C)c5c4)ncn3)cn2)CC1 CHEMBL4214634 IC50 1.6 nM
Cc1nc2c(F)cc(-c3cc(Nc4cnc(CN5CCN(C6CCCC6)CC5)cn4)ncn3)cc2n1C(C)C CHEMBL4216534 IC50 1.8 nM
CCN1CCN(Cc2ccc(Nc3ncc(F)c(-c4cc(F)c5nc(C)n(C(C)C)c5c4)n3)nc2)CC1 CHEMBL3301610 IC50 1.9 nM
CN1CCN(Cc2ccc(NC(=O)c3n[nH]cc3Nc3ncnc4[nH]ccc34)cc2)CC1 CHEMBL4077071 IC50 1.96 nM
O[C@@H]1CCN(c2ccc(Nc3ncc4c5ccnc(F)c5n(C5CCCC5)c4n3)nc2)C1 CHEMBL3702091 IC50 2.0 nM
CC(C)N1CCN(c2ccc(Nc3ncc4cc5n(c4n3)C3(CCCCC3)CNC5=O)nc2)CC1 CHEMBL3904602 IC50 2.0 nM
O=S1(=O)CC=C(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CC1 CHEMBL3702167 IC50 2.2 nM
Cc1nc2c(F)cc(-c3cc(Nc4cnc(CN5CCN(CC6CC6)CC5)cn4)ncn3)cc2n1C(C)C CHEMBL4213557 IC50 2.2 nM
Cc1nc2c(F)cc(-c3cc(Nc4cnc(CN5CCN(C(C)C)CC5)cn4)ncn3)cc2n1C(C)C CHEMBL4202432 IC50 2.3 nM
CCC1CCc2nc3c(F)cc(-c4nc(Nc5ccc(CN6CCN(C)CC6)cn5)ncc4F)cc3n21 CHEMBL4217694 IC50 2.4 nM
c1ccc2c(c1)c1cnc(Nc3ccc(N4CCNCC4)cn3)nc1n2C1CCCCC1 CHEMBL3698658 IC50 2.5 nM
c1cc2c3cnc(Nc4ccc(CN5CCOCC5)cn4)nc3n(C3CCCC3)c2cn1 CHEMBL3702049 IC50 2.6 nM
c1cc2c3cnc(Nc4ccc(N5CCNCC5)cc4)nc3n(C3CC4CCC3C4)c2cn1 CHEMBL3698675 IC50 2.6 nM
CN(C)C1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)CC1 CHEMBL3698649 IC50 2.6 nM
OCC1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)CC1 CHEMBL3698733 IC50 2.6 nM
O=C1CNCCN1Cc1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nc1 CHEMBL3702128 IC50 2.7 nM
CCN1CCN(Cc2cnc(Nc3cc(-c4cc(F)c5nc(C)n(C(C)C)c5c4)ncn3)cn2)CC1 CHEMBL4208504 IC50 2.7 nM
OCC1CCN(c2ccc(Nc3ncc4c5ccnc(F)c5n(C5CCCC5)c4n3)nc2)CC1 CHEMBL3702093 IC50 2.8 nM
CN(C)C1CCN(c2ccc(Nc3ncc4c5ccnc(Cl)c5n(C5CCCC5)c4n3)nc2)CC1 CHEMBL3702060 IC50 2.8 nM
c1cc2c3cnc(Nc4ccc(N5CCNCC5)cc4)nc3n(C3CCCC3)c2cn1 CHEMBL3698639 IC50 2.9 nM
CCN1CCN(Cc2ccc(Nc3cc(-c4cc(F)c5nc(C)n(C(C)C)c5c4)ccn3)nc2)CC1 CHEMBL4208198 IC50 2.9 nM
CCN1CCC(Cc2cnc(Nc3cc(-c4cc(F)c5nc(C)n(C(C)C)c5c4)ncn3)cn2)CC1 CHEMBL4207218 IC50 2.9 nM
O=C1CN(Cc2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CCN1 CHEMBL3702127 IC50 3.0 nM
c1ccc2c(c1)c1cnc(Nc3ccc(N4CCNCC4)cn3)nc1n2C1CCCCCC1 CHEMBL3698674 IC50 3.1 nM
CCNC1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CC1 CHEMBL3642019 IC50 3.1 nM
O=S(=O)(c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nc1)N1CCNCC1 CHEMBL3702129 IC50 3.1 nM
O=C(O)CN1CCN(Cc2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CC1 CHEMBL3702122 IC50 3.3 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(-c4csc5c(=O)cc(N6CCOCC6)oc45)cc3)nc2n1C1CCCC1 CHEMBL5190816 IC50 3.3 nM
CN1CCN(Cc2ccc(NC(=O)c3n[nH]cc3Nc3ncnc4sccc34)cc2)CC1 CHEMBL4075720 IC50 3.33 nM
c1cc2c3cnc(Nc4ccc(N5CCNCC5)cn4)nc3n(C34CC5CC(CC(C5)C3)C4)c2cn1 CHEMBL3698661 IC50 3.5 nM
O=C(O)CN1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)CC1 CHEMBL3702120 IC50 3.6 nM
c1ccc2c(c1)c1cnc(Nc3ccc(N4CCNCC4)cc3)nc1n2C1CCCC1 CHEMBL3698682 IC50 3.7 nM
CC1(C)CCc2nc3c(F)cc(-c4nc(Nc5ccc(CN6CCNCC6)cn5)ncc4F)cc3n21 CHEMBL4209329 IC50 3.7 nM
C[C@@H](O)CNC1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)CC1 CHEMBL3641997 IC50 3.8 nM
O=S(=O)(c1ccc(Nc2ncc3c4ccnc(F)c4n(C4CCCC4)c3n2)nc1)N1CCNCC1 CHEMBL3702130 IC50 3.9 nM
CCN1CCC(Oc2cnc(Nc3cc(-c4cc(F)c5nc(C)n(C(C)C)c5c4)ncn3)cn2)CC1 CHEMBL4208875 IC50 4.0 nM
CN1CCN(Cc2ccc(Nc3ncc(F)c(-c4cc(F)c5nc6n(c5c4)C(C)(C)CC6)n3)nc2)CC1 CHEMBL4215702 IC50 4.0 nM
COc1ccc(F)c(F)c1C(=O)c1cnc(NC2CCN(S(C)(=O)=O)CC2)nc1N CHEMBL384304 IC50 4.0 nM
Cc1cc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)cnc1N1CCNCC1 CHEMBL3698641 IC50 4.2 nM
Clc1nccc2c3cnc(Nc4ccc(N5CCNCC5)cn4)nc3n(C3CCCC3)c12 CHEMBL3237444 IC50 4.3 nM
c1cc2c3cnc(Nc4ccc(N5CCNCC5)cn4)nc3n(C3CCCC3)c2cn1 CHEMBL3237442 IC50 4.4 nM
c1cnc2c(c1)c1cnc(Nc3ccc(N4CCNCC4)cc3)nc1n2C1CCCC1 CHEMBL3698671 IC50 4.4 nM
CC1CCC(n2c3cnccc3c3cnc(Nc4ccc(N5CCNCC5)cn4)nc32)CC1 CHEMBL3237702 IC50 4.4 nM
CCN1CCN(Cc2ccc(Nc3cc(-c4cc(F)c5nc(C)n(C(C)C)c5c4)ncn3)nc2)CC1 CHEMBL4214898 IC50 4.4 nM
c1cc2c3cnc(Nc4ccc(N5CCNCC5)cn4)cc3n(C3CCCCC3)c2cn1 CHEMBL3702142 IC50 4.6 nM
CCN(CC)C1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CC1 CHEMBL3702052 IC50 4.6 nM
OC[C@H](O)CNC1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)CC1 CHEMBL3642002 IC50 4.8 nM
O[C@H]1CCN(c2ccc(Nc3ncc4c5ccnc(F)c5n(C5CCCC5)c4n3)nc2)C1 CHEMBL3702092 IC50 4.8 nM
CC(C)n1c2cnccc2c2cnc(Nc3ccc(N4CCC(N(C)C)CC4)nn3)nc21 CHEMBL3702067 IC50 4.8 nM
COCCN1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CC1 CHEMBL3702050 IC50 4.9 nM
OCCN1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CC1 CHEMBL3702096 IC50 4.9 nM
CN(C)C1CCN(c2ccc(Nc3ncc4c5ccnc(F)c5n(C5CCCC5)c4n3)nn2)CC1 CHEMBL3702154 IC50 5.0 nM
c1cc2c3cnc(Nc4ccc(N5CCNCC5)cn4)nc3n(C3CC4CCC3C4)c2cn1 CHEMBL3698659 IC50 5.1 nM
OCCNC1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CC1 CHEMBL3642014 IC50 5.1 nM
O=C(O)CNC1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CC1 CHEMBL3642032 IC50 5.1 nM
C[C@H](CO)NC1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CC1 CHEMBL3641992 IC50 5.1 nM
c1cc2c3cnc(Nc4ccc(C5CCNCC5)cn4)nc3n(C3CCCC3)c2cn1 CHEMBL3702159 IC50 5.3 nM
CN(C)C1CC2CCC(C1)N2c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nc1 CHEMBL3702065 IC50 5.3 nM
c1cc2c3cnc(Nc4ccc(N5CCCNCC5)cn4)nc3n(C3CCCC3)c2cn1 CHEMBL3698683 IC50 5.6 nM
C[C@H](O)CNC1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)CC1 CHEMBL3641995 IC50 5.7 nM
C[C@@H](C1CCCCC1)n1c2cnccc2c2cnc(Nc3ccc(N4CCNCC4)cn3)nc21 CHEMBL3698664 IC50 5.7 nM
O=C(O)CNC1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)CC1 CHEMBL3642033 IC50 5.7 nM
CCN(CC)C1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)CC1 CHEMBL3702053 IC50 5.8 nM
Cc1nc2c(F)cc(-c3cc(Nc4cnc(CN5CCN(CC(F)(F)F)CC5)cn4)ncn3)cc2n1C(C)C CHEMBL4214123 IC50 5.8 nM
OC1CCC(n2c3cnccc3c3cnc(Nc4ccc(N5CCNCC5)cn4)nc32)CC1 CHEMBL3971812 IC50 5.9 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(N4CCNCC4)cn3)nc2n1C1CCCC1 CHEMBL3545110 IC50 6.0 nM
c1cc2c3cnc(Nc4ccc(N5CCNCC5)cn4)nc3n(C3CCC3)c2cn1 CHEMBL3698665 IC50 6.1 nM
c1cc2c3cnc(Nc4nc(CN5CCNCC5)cs4)nc3n(C3CCCC3)c2cn1 CHEMBL3702071 IC50 6.2 nM
OCC(CO)NC1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)CC1 CHEMBL3642001 IC50 6.3 nM
CCN1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CC1 CHEMBL3702047 IC50 6.4 nM
O=C(c1csc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)n1)N1CCNCC1 CHEMBL3698684 IC50 6.5 nM
Oc1ccc(-c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)cn1 CHEMBL3702168 IC50 6.5 nM
c1cc2c3cnc(Nc4ccc(N5CCNCC5)nn4)nc3n(C3CCCC3)c2cn1 CHEMBL3698642 IC50 6.6 nM
c1cc2c3cnc(Nc4ccc(N5CCCNCC5)nn4)nc3n(C3CCCC3)c2cn1 CHEMBL3698747 IC50 6.8 nM
CN(CCO)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nn1 CHEMBL3702191 IC50 6.9 nM
C1=C(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CCNC1 CHEMBL3702158 IC50 7.0 nM
CC(C)(C)n1c2cnccc2c2cnc(Nc3ccc(N4CCNCC4)cn3)nc21 CHEMBL3698662 IC50 7.0 nM
O[C@H]1CCCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)C1 CHEMBL3698735 IC50 7.1 nM
N#Cc1ccc2c3cnc(Nc4ccc(N5CCNCC5)cn4)nc3n(C3CCCC3)c2c1 CHEMBL3698676 IC50 7.2 nM
OCCC1CCN(c2ccc(Nc3ncc4c5ccnc(F)c5n(C5CCCC5)c4n3)nc2)CC1 CHEMBL3702095 IC50 7.6 nM
Cc1cc(-c2cnc(Nc3cnc(CN4CCN(C)CC4)cn3)s2)nc(OC2CCCCC2)n1 CHEMBL210540 IC50 7.8 nM
O=C(c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nc1)N1CCNCC1 CHEMBL3702123 IC50 8.0 nM
CN1CCN(c2ccc(Nc3ncc4c5ccccc5n(C5CCCC5)c4n3)nc2)CC1 CHEMBL3702198 IC50 8.0 nM
c1ccc(-n2c3cnccc3c3cnc(Nc4ccc(N5CCNCC5)cn4)nc32)cc1 CHEMBL3698650 IC50 8.0 nM
C[C@@H](CO)NC1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CC1 CHEMBL3642030 IC50 8.0 nM
NC1CCN(c2ccc(Nc3ncc4c5ccccc5n(C5CCCC5)c4n3)nn2)CC1 CHEMBL3702208 IC50 8.0 nM
C[C@H]1CC[C@@H](n2c3cnccc3c3cnc(Nc4ccc5c(n4)CCN(C(=O)CO)C5)nc32)CC1 CHEMBL5207533 IC50 8.0 nM
OC1CCN(Cc2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CC1 CHEMBL3702117 IC50 8.2 nM
NCC1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)CC1 CHEMBL3698731 IC50 8.8 nM
c1ccc2c(c1)c1cnc(Nc3ccc(N4CCNCC4)nn3)nc1n2C1CCCC1 CHEMBL3702207 IC50 8.8 nM
CC1(n2c3cnccc3c3cnc(Nc4ccc(N5CCNCC5)cn4)nc32)CCC1 CHEMBL3698668 IC50 8.9 nM
OC1CCN(C2CCN(c3ccc(Nc4ncc5c6ccncc6n(C6CCCC6)c5n4)nn3)CC2)CC1 CHEMBL3642011 IC50 9.0 nM
O=S1(=O)CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)CC1 CHEMBL3698724 IC50 9.2 nM
CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCNCC4)cn3)nc2n(C2CCCC2)c1=O CHEMBL189963 IC50 9.3 nM
CCOC(=O)CN1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)CC1 CHEMBL3702119 IC50 9.8 nM
CN1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CC1 CHEMBL3698638 IC50 10.0 nM
O[C@H]1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)C1 CHEMBL3698655 IC50 10.0 nM
CN(C)CCNC1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)CC1 CHEMBL3642035 IC50 10.0 nM
C[C@H]1CN(c2ccc(Nc3ncc4c5ccncc5n(C5CCC5)c4n3)nc2)CCN1 CHEMBL3702244 IC50 10.0 nM
NC1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CC1 CHEMBL3698647 IC50 10.0 nM
NC1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)CC1 CHEMBL3698744 IC50 10.0 nM
O=C(NC1CCNCC1)c1n[nH]cc1NC(=O)c1c(Cl)cccc1Cl CHEMBL445813 IC50 10.0 nM
C[C@H](CO)NC1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)CC1 CHEMBL3642000 IC50 11.0 nM
CC[C@@H](C)n1c2cnccc2c2cnc(Nc3ccc(N4CCN[C@@H](C)C4)cn3)nc21 CHEMBL3702221 IC50 11.0 nM
CNC1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)CC1 CHEMBL3698708 IC50 11.0 nM
O=c1[nH]ccc2c3cnc(Nc4ccc(N5CCNCC5)cn4)nc3n(C3CCCC3)c12 CHEMBL3237446 IC50 11.0 nM
N[C@@H]1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)C1 CHEMBL3698739 IC50 11.0 nM
CCOC(=O)CN1CCN(Cc2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CC1 CHEMBL3702121 IC50 11.0 nM
CC[C@@H](C)n1c2cnccc2c2cnc(Nc3ccc(N4CCNCC4)cn3)nc21 CHEMBL3702220 IC50 11.0 nM
CCN(CCO)C1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)CC1 CHEMBL3642010 IC50 11.0 nM
OC1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)CC1 CHEMBL3698732 IC50 11.1 nM
c1cc2c3cnc(Nc4ccc(N[C@@H]5CCNC5)nn4)nc3n(C3CCCC3)c2cn1 CHEMBL3698721 IC50 11.2 nM
CC1(C)CCc2nc3c(F)cc(-c4nc(Nc5ccc(CN6CCN(CCF)CC6)cn5)ncc4F)cc3n21 CHEMBL4210707 IC50 11.2 nM
C[C@@H]1CN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)CCN1 CHEMBL3698640 IC50 11.5 nM
C[C@@H]1C[C@H]2CN1CCn1nc3c(cccc3c1O)-c1nc3c(cccc3nc1O)O2 CHEMBL215803 IC50 12.0 nM
CN(C)C1CCN(c2ccc(Nc3ncc4c5ccccc5n(C5CCCC5)c4n3)nc2)CC1 CHEMBL3702209 IC50 12.0 nM
OC[C@@H](O)CNC1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)CC1 CHEMBL3642036 IC50 12.0 nM
C[C@@H](O)CNC1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CC1 CHEMBL3642016 IC50 12.0 nM
c1cc2c3cnc(Nc4ccc(N5CCC(NC6CC6)CC5)cn4)nc3n(C3CCCC3)c2cn1 CHEMBL3642020 IC50 12.0 nM
c1ccc(-n2c3cnccc3c3cnc(Nc4ccc(N5CCNCC5)cn4)cc32)cc1 CHEMBL3702135 IC50 12.0 nM
OC1CN(C2CCN(c3ccc(Nc4ncc5c6ccncc6n(C6CCCC6)c5n4)nc3)CC2)C1 CHEMBL3642029 IC50 12.0 nM
CC1(C)CN(c2ccc(Nc3ncc4c5ccncc5n(C5CCC5)c4n3)nn2)CCN1 CHEMBL3702248 IC50 12.0 nM
OCCNC1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)CC1 CHEMBL3641994 IC50 12.0 nM
c1cc2c3cnc(Nc4ccc(NC5CCNCC5)nn4)nc3n(C3CCCC3)c2cn1 CHEMBL3698726 IC50 12.4 nM
CC(C)N1CCN(Cc2ccc(Nc3ncc(F)c(-c4cc(F)c5nc6n(c5c4)C(C)CC6)n3)nc2)CC1 CHEMBL4211828 IC50 12.7 nM
OCCCNC1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)CC1 CHEMBL3642009 IC50 13.0 nM
c1cc2c3cnc(Nc4ccc(N5CCNCC5)cn4)nc3n(C3CCCC3)c2nn1 CHEMBL3237448 IC50 13.0 nM
Fc1ccc(-n2c3cnccc3c3cnc(Nc4ccc(N5CCNCC5)cn4)nc32)cc1 CHEMBL3698651 IC50 13.0 nM
CNC1CCN(c2ccc(Nc3ncc4c5ccnc(F)c5n(C5CCCC5)c4n3)nc2)CC1 CHEMBL3702210 IC50 13.0 nM
C[C@@H](CO)NC1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)CC1 CHEMBL3641998 IC50 13.0 nM
OCCCNc1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nn1 CHEMBL3702197 IC50 13.0 nM
CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCN(C/C=C/C(F)(F)F)CC4)cn3)nc2n(C2CCCC2)c1=O CHEMBL5277376 IC50 13.0 nM
c1cc2c3cnc(Nc4ccc(N5CCNCC5)cn4)nc3n(C3CCCCC3)c2cn1 CHEMBL3237451 IC50 13.1 nM
CN(C)C1CN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)CCC1O CHEMBL3642038 IC50 13.3 nM
N#Cc1nccc2c3cnc(Nc4ccc(N5CCNCC5)cn4)nc3n(C3CCCC3)c12 CHEMBL3237447 IC50 13.4 nM
CN(CCO)C1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)CC1 CHEMBL3641996 IC50 14.0 nM
C[C@H](O)CNC1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CC1 CHEMBL3642015 IC50 14.0 nM
CCCNC1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CC1 CHEMBL3642021 IC50 14.0 nM
CCC(C)(C)n1c2cnccc2c2cnc(Nc3ccc(N4CCC(N(C)C)CC4)nn3)nc21 CHEMBL3702063 IC50 14.0 nM
O[C@@H]1CCCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)C1 CHEMBL3698734 IC50 14.0 nM
C[C@@H](CO)Nc1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nn1 CHEMBL3702196 IC50 14.0 nM
CN1CCN(Cc2ccc(NC(=O)c3n[nH]cc3Nc3ccncn3)cc2)CC1 CHEMBL5399420 IC50 14.33 nM
CNC1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCC5)c4n3)nc2)CC1 CHEMBL3702245 IC50 15.0 nM
OC1CCCN(Cc2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)C1 CHEMBL3702118 IC50 15.0 nM
C=CC(=O)N1CCN(c2ccc(Nc3ncc4c(C)c(C(C)=O)c(=O)n(C5CCCC5)c4n3)nc2)CC1 CHEMBL4860767 IC50 15.0 nM
c1cc2c3cnc(Nc4ccc(N[C@H]5CCNC5)nn4)nc3n(C3CCCC3)c2cn1 CHEMBL3698722 IC50 15.1 nM
c1ccc2c(c1)c1cnc(Nc3ccc(N4CCNCC4)cn3)nc1n2C1CCOCC1 CHEMBL3698673 IC50 15.3 nM
N[C@H]1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)C1 CHEMBL3698738 IC50 15.7 nM
COCCN1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)CC1 CHEMBL3702051 IC50 15.8 nM
CCN1CCN(Cc2ccc(Nc3ncc(F)c(-c4ccc5nc6n(c5c4)C(C)(C)CC6)n3)nc2)CC1 CHEMBL4210028 IC50 15.8 nM
O=S1(=O)CCC(Nc2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)C1 CHEMBL3698723 IC50 15.9 nM
CCC(CC)n1c2cnccc2c2cnc(Nc3ccc(N4CCC(N(C)C)CC4)nn3)nc21 CHEMBL3702070 IC50 16.0 nM
CCC(CC)n1c2cnccc2c2cnc(Nc3ccc(N4CCNCC4)cn3)nc21 CHEMBL3702068 IC50 16.0 nM
CN(C)C1CCN(C(=O)c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CC1 CHEMBL3702132 IC50 16.0 nM
CN(C)C1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCC5)c4n3)nc2)CC1 CHEMBL3702241 IC50 16.0 nM
C[C@@H](O)CNc1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nn1 CHEMBL3702193 IC50 16.0 nM
O[C@H]1CCN(C2CCN(c3ccc(Nc4ncc5c6ccncc6n(C6CCCC6)c5n4)nn3)CC2)C1 CHEMBL3642006 IC50 16.0 nM
COc1ccc2c3cnc(Nc4ccc(N5CCNCC5)cn4)nc3n(C3CCCC3)c2n1 CHEMBL3702087 IC50 16.0 nM
O=S1(=O)CC=C(c2ccc(Nc3ncc4c5ccnc(F)c5n(C5CCCC5)c4n3)nc2)CC1 CHEMBL3702173 IC50 16.0 nM
CNCCN(C)C1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)CC1 CHEMBL3641999 IC50 16.0 nM
c1cc2c3cnc(Nc4ccc(N5CCNCC5)nn4)nc3n(C3CCC3)c2cn1 CHEMBL3702246 IC50 16.0 nM
OCCNc1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nn1 CHEMBL3702192 IC50 16.1 nM
Oc1cc(-c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)ccn1 CHEMBL3702166 IC50 16.6 nM
c1cc2c3cnc(Nc4ccc(N5CCNCC5)cn4)cc3n(C3CCSC3)c2cn1 CHEMBL3702141 IC50 17.0 nM
CN(C)CCN(C)C1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)CC1 CHEMBL3642034 IC50 17.0 nM
O[C@H]1CCN(Cc2csc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)n2)C1 CHEMBL3702072 IC50 17.0 nM
Fc1nccc2c3cnc(Nc4ccc(N5CCNCC5)cn4)nc3n(C3CCCC3)c12 CHEMBL3237443 IC50 17.0 nM
CCN1CCN(Cc2ccc(Nc3nccc(-c4cc(F)c5nc6n(c5c4)C(C)(C)CC6)n3)nc2)CC1 CHEMBL4205645 IC50 17.4 nM
O[C@@H]1CCCN(C2CCN(c3ccc(Nc4ncc5c6ccncc6n(C6CCCC6)c5n4)nn3)CC2)C1 CHEMBL3642007 IC50 18.0 nM
OC1CCN(C2CCN(c3ccc(Nc4ncc5c6ccncc6n(C6CCCC6)c5n4)nc3)CC2)CC1 CHEMBL3642018 IC50 18.0 nM
CN(CC(=O)O)C1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CC1 CHEMBL3642026 IC50 18.0 nM
COCCCNCC(=O)N1CCN(c2ccc(Nc3ncc4c(C)c(C(C)=O)c(=O)n(C5CCCC5)c4n3)nc2)CC1 CHEMBL3905696 IC50 18.0 nM
Cc1nc(Nc2ncc(F)c(-c3cc(F)c4nc5n(c4c3)C(C)(C)CC5)n2)ccc1CN1CCNCC1 CHEMBL4207474 IC50 18.7 nM
CNC1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCC5)c4n3)nn2)CC1 CHEMBL3641990 IC50 19.0 nM
c1cc2c3cnc(Nc4ccc(N5CCC(NC6CCC6)CC5)cn4)nc3n(C3CCCC3)c2cn1 CHEMBL3642023 IC50 19.0 nM
CC1(C)CCc2nc3c(F)cc(-c4nc(Nc5ccc(CN6CCN(C7CC7)CC6)cn5)ncc4F)cc3n21 CHEMBL4207451 IC50 19.0 nM
CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCN(C(=O)/C(C#N)=C/c5ccccc5)CC4)cn3)nc2n(C2CCCC2)c1=O CHEMBL5277470 IC50 19.0 nM
Cc1nc(Nc2c[nH]nc2C(=O)Nc2ccc(CN3CCN(C)CC3)cc2)c2cc(C(C)C)sc2n1 CHEMBL4160544 IC50 19.24 nM
C[C@H]1CN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)CCN1 CHEMBL3698645 IC50 19.5 nM
c1cc2c3cnc(Nc4ccc(N5CCCC5)nn4)nc3n(C3CCCC3)c2cn1 CHEMBL3698741 IC50 19.7 nM
CC[C@@H](C)n1c2cnccc2c2cnc(Nc3ccc(N4CCNC(C)(C)C4)nn3)nc21 CHEMBL3702224 IC50 20.0 nM
CC(C)NC1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CC1 CHEMBL3642024 IC50 20.0 nM
c1cc2c3cnc(Nc4ccc(N[C@@H]5CCNC5)cn4)nc3n(C3CCCC3)c2cn1 CHEMBL3698694 IC50 20.0 nM
CN1CC[C@H](c2c(O)cc(O)c3c(=O)cc(-c4ccccc4Cl)oc23)[C@H](O)C1 CHEMBL428690 IC50 20.0 nM
CN(C)C1CCN(S(=O)(=O)c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CC1 CHEMBL3702131 IC50 20.5 nM
CC[C@@H](C)n1c2cnccc2c2cnc(Nc3ccc(N4CCN[C@@H](C)C4)nn3)nc21 CHEMBL3702217 IC50 21.0 nM
c1cnc2c(c1)c1cnc(Nc3ccc(N4CCNCC4)cn3)nc1n2C1CCCC1 CHEMBL3698670 IC50 21.0 nM
COc1ccc(-n2c3cnccc3c3cnc(Nc4ccc(N5CCNCC5)cn4)nc32)cc1 CHEMBL3698652 IC50 21.0 nM
c1cc2c3cnc(Nc4ccc(N5CCNCC5)cn4)nc3n(C3CCCCCC3)c2cn1 CHEMBL3698669 IC50 21.0 nM
FCCNC1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CC1 CHEMBL3642022 IC50 21.0 nM
Oc1nccc2c3cnc(Nc4ccc(CN5CCNCC5)cn4)nc3n(C3CCCC3)c12 CHEMBL3702116 IC50 21.0 nM
FC(F)(F)C1CN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CCN1 CHEMBL3702074 IC50 21.0 nM
COc1nccc2c3cnc(Nc4ccc(N5CCNCC5)cn4)nc3n(C3CCCC3)c12 CHEMBL3698687 IC50 22.0 nM
OC1CN(C2CCN(c3ccc(Nc4ncc5c6ccncc6n(C6CCCC6)c5n4)nn3)CC2)C1 CHEMBL3642004 IC50 22.0 nM
CC1CN(c2ccc(Nc3ncc4c5ccnc(F)c5n(C5CCCC5)c4n3)nc2)CC(C)N1 CHEMBL3702094 IC50 22.0 nM
CN1CCN(c2ccc(Nc3ncc4c5ccccc5n(C5CCCC5)c4n3)nn2)CC1 CHEMBL3702201 IC50 22.0 nM
CCC1CCc2nc3c(F)cc(-c4nc(Nc5ccc(CN6CCN(CC)CC6)cn5)ncc4F)cc3n21 CHEMBL4213847 IC50 22.0 nM
CC[C@@H](C)n1c2cnccc2c2cnc(Nc3ccc(N4CCNCC4)nn3)nc21 CHEMBL3702223 IC50 23.0 nM
C[C@H]1CN(c2ccc(Nc3ncc4c5ccccc5n(C5CCCC5)c4n3)nn2)CCN1 CHEMBL3702202 IC50 23.0 nM
CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCN(C(=O)CNCCN)CC4)cn3)nc2n(C2CCCC2)c1=O CHEMBL3986282 IC50 23.0 nM
CCN1CCN(Cc2ccc(Nc3cc(-c4cc(F)c5nc(C)n(C(C)C)c5c4)ccn3)nn2)CC1 CHEMBL4205366 IC50 23.6 nM
CN(C)[C@H]1CN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)CC[C@@H]1O CHEMBL3702160 IC50 24.0 nM
O=S1(=O)CCC(Nc2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)C1 CHEMBL3698696 IC50 24.0 nM
c1cc2c3cnc(Nc4ccc(N[C@H]5CCNC5)cn4)nc3n(C3CCCC3)c2cn1 CHEMBL3698695 IC50 24.0 nM
O[C@H]1CCN(c2ccc(Nc3ncc4c5ccnc(F)c5n(C5CCCC5)c4n3)nn2)C1 CHEMBL3702211 IC50 24.0 nM
c1cc2c3cnc(Nc4ccc(N5CCOCC5)nn4)nc3n(C3CCCC3)c2cn1 CHEMBL3698736 IC50 24.3 nM
CCC(C)(C)n1c2cnccc2c2cnc(Nc3ccc(N4CCNCC4)cn3)nc21 CHEMBL3702064 IC50 25.0 nM
OCC1(n2c3cnccc3c3cnc(Nc4ccc(N5CCNCC5)cn4)nc32)CCCC1 CHEMBL3698679 IC50 25.0 nM
FC(F)(F)c1cccc(-n2c3cnccc3c3cnc(Nc4ccc(N5CCNCC5)cn4)cc32)c1 CHEMBL3702136 IC50 26.0 nM
O[C@H]1CCN(Cc2csc(Nc3ncc4c5ccnc(F)c5n(C5CCCC5)c4n3)n2)C1 CHEMBL3702086 IC50 26.0 nM
COC(=O)CNC1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)CC1 CHEMBL3642031 IC50 26.0 nM
C[C@H](O)CNc1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nn1 CHEMBL3702194 IC50 26.0 nM
c1cc2c3cnc(Nc4ccc(N5CCC(N6CCOCC6)CC5)nn4)nc3n(C3CCCC3)c2cn1 CHEMBL3642003 IC50 26.0 nM
c1cc2c3cnc(Nc4ccc(NCC5CCNC5)nn4)nc3n(C3CCCC3)c2cn1 CHEMBL3698728 IC50 26.6 nM
CN(C)C1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCC5)c4n3)nn2)CC1 CHEMBL3702247 IC50 27.0 nM
CCN1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)CC1 CHEMBL3702045 IC50 27.0 nM
C[C@@H]1CN(c2ccc(Nc3ncc4c5ccnc(F)c5n(C5CCCC5)c4n3)nn2)CCN1 CHEMBL3702155 IC50 27.0 nM
CC[C@@H](C)n1c2cnccc2c2cnc(Nc3ccc(N4CCC(NC)CC4)nn3)nc21 CHEMBL3702218 IC50 27.0 nM
O[C@@H]1CCN(c2ccc(Nc3ncc4c5ccccc5n(C5CCCC5)c4n3)nc2)C1 CHEMBL3702204 IC50 27.0 nM
CCN(CCO)C1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CC1 CHEMBL3642028 IC50 28.0 nM
CC1(C)CN(c2ccc(Nc3ncc4c5ccncc5n(C5CCC5)c4n3)nc2)CCN1 CHEMBL3702243 IC50 28.0 nM
CC(=O)OCOC(=O)N1CCN(c2ccc(Nc3ncc4c(C)c(C(C)=O)c(=O)n(C5CCCC5)c4n3)nc2)CC1 CHEMBL3972685 IC50 28.0 nM
CCN1CCN(Cc2ccc(Nc3ncc(F)c(-c4cc(F)c5nc6n(c5c4)C(C)CC6)n3)nc2)CC1 CHEMBL4212542 IC50 28.0 nM
COc1ccc(NC(=S)NC(=O)c2cn(-c3ccccc3)nc2-c2ccc(OC)cc2)cc1 CHEMBL2426395 IC50 29.0 nM
C[C@@H](CO)n1c2cnccc2c2cnc(Nc3ccc(N4CCNCC4)cn3)nc21 CHEMBL3237449 IC50 29.0 nM
CC1CN(c2ccc(Nc3ncc4c5ccccc5n(C5CCCC5)c4n3)nc2)CC(C)N1 CHEMBL3702203 IC50 30.0 nM
c1cc2c3cnc(Nc4ccc(N5CCC(N6CCCC6)CC5)nn4)nc3n(C3CCCC3)c2cn1 CHEMBL3641993 IC50 30.0 nM
O[C@H]1CCCN(C2CCN(c3ccc(Nc4ncc5c6ccncc6n(C6CCCC6)c5n4)nn3)CC2)C1 CHEMBL3642008 IC50 30.0 nM
c1cc2c3cnc(Nc4ccc(N5CCNCC5)cn4)nc3n(CC3CCCCC3)c2cn1 CHEMBL3698667 IC50 30.4 nM
c1cc2c3cnc(Nc4ccc(NC5CCNCC5)cn4)nc3n(C3CCCC3)c2cn1 CHEMBL3698700 IC50 31.0 nM
Cn1c(=O)ccc2c3cnc(Nc4ccc(N5CCNCC5)cn4)nc3n(C3CCCC3)c21 CHEMBL3702089 IC50 31.0 nM
CCc1cnn2c(NCc3ccc[n+]([O-])c3)cc(N3CCCC[C@H]3CCO)nc12 CHEMBL2103840 Kd apparent 32.0 nM
COc1ccc(NC(=S)NC(=O)c2cn(-c3ccccc3)nc2-c2ccc(F)cc2)cc1 CHEMBL2426391 IC50 33.0 nM
c1cc2c3cnc(Nc4ccc(CN5CCNCC5)cn4)nc3n(C3CCCC3)c2cn1 CHEMBL3702114 IC50 33.0 nM
COc1nccc2c3cnc(Nc4ccc(N5CCC(N(C)C)CC5)cn4)nc3n(C3CCCC3)c12 CHEMBL3702054 IC50 33.0 nM
Cc1nc(Nc2c[nH]nc2C(=O)Nc2ccc(CN3CCOCC3)cc2)c2cc(C(C)C)sc2n1 CHEMBL4171138 IC50 33.21 nM
C[C@H](CO)Nc1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nn1 CHEMBL3702195 IC50 33.7 nM
CC1(C)CN(c2ccc(Nc3ncc4c5ccccc5n(C5CCCC5)c4n3)nn2)CCN1 CHEMBL3702199 IC50 34.0 nM
COC(=O)CNC1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CC1 CHEMBL3642027 IC50 34.0 nM
CCN1CCN(c2ccc(Nc3ncc4c(C)c(C(C)=O)c(=O)n(C5CCCC5)c4n3)nc2)CC1 CHEMBL3954429 IC50 34.0 nM
O=S1(=O)CCC(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CC1 CHEMBL3702172 IC50 35.0 nM
O[C@@H]1CCN(C2CCN(c3ccc(Nc4ncc5c6ccncc6n(C6CCCC6)c5n4)nn3)CC2)C1 CHEMBL3642005 IC50 36.0 nM
CCN1CCN(Cc2ccc(Nc3ncc(F)c(-c4cc(F)c5nc6n(c5c4)CC(C)(C)C6)n3)nc2)CC1 CHEMBL4207804 IC50 36.0 nM
CN(CCO)C1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CC1 CHEMBL3642013 IC50 37.0 nM
FC(F)(F)CNC1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CC1 CHEMBL3642025 IC50 38.0 nM
COc1cc(-c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)ccn1 CHEMBL3702164 IC50 38.0 nM
c1ccc2c(c1)CCC2n1c2cnccc2c2cnc(Nc3ccc(N4CCNCC4)cn3)nc21 CHEMBL3698660 IC50 38.0 nM
CC1CN(c2ccc(Nc3ncc4c5ccccc5n(C5CCCC5)c4n3)nn2)CC(C)N1 CHEMBL3702206 IC50 39.0 nM
CCN(CC)c1cnc2ccc(-c3nc(Nc4ccc(N5CCNCC5)cn4)ncc3F)cc2n1 CHEMBL5079648 IC50 39.0 nM
C1=CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)CC1 CHEMBL3702156 IC50 40.0 nM
CN(C)[C@H]1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)C1 CHEMBL3702188 IC50 40.0 nM
CN(C)[C@@H]1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)C1 CHEMBL3702189 IC50 40.0 nM
CN(C)[C@@H]1CN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)CC[C@H]1O CHEMBL3642037 IC50 41.0 nM
COc1ccc(NC(=S)NC(=O)c2cn(-c3ccccc3)nc2-c2ccc(Cl)cc2)cc1 CHEMBL2426387 IC50 42.0 nM
CC[C@@H](C)n1c2cnccc2c2cnc(Nc3ccc(N4CCC(NC)CC4)cn3)nc21 CHEMBL3702225 IC50 42.0 nM
COc1ccc(NC(=S)NC(=O)c2cn(-c3ccccc3)nc2-c2ccc(C)cc2)cc1 CHEMBL2426383 IC50 43.0 nM
CN1CC[C@H](c2c(O)cc(O)c3c(=O)cc(/C=C/c4c(Cl)cccc4Cl)oc23)[C@H](O)C1 CHEMBL4079206 IC50 45.0 nM
CCN1CCN(Cc2ccc(Nc3ncc(F)c(-c4cc(F)c5nc6n(c5c4)CCCC6)n3)nc2)CC1 CHEMBL4208366 IC50 45.6 nM
CCN1CCN(Cc2ccc(Nc3ncc(F)c(-c4cc(F)c5nc6n(c5c4)C(C)(C)CC6)n3)nc2C)CC1 CHEMBL4211479 IC50 46.0 nM
Cc1nccc2c3cnc(Nc4ccc(N5CCNCC5)cn4)nc3n(C3CCCC3)c12 CHEMBL3237445 IC50 47.0 nM
c1cc2c3cnc(Nc4ccc(N5CCCCC5)nn4)nc3n(C3CCCC3)c2cn1 CHEMBL3698737 IC50 48.0 nM
CN(C)C1CCN(c2ccc(Nc3ncc4c5ccccc5n(C5CCCC5)c4n3)nn2)CC1 CHEMBL3702200 IC50 48.0 nM
CC[C@@H](C)n1c2cnccc2c2cnc(Nc3ccc(N4CC[C@@H](O)C4)nn3)nc21 CHEMBL3702219 IC50 49.0 nM
COc1ccc(NC(=S)NC(=O)c2cn(-c3ccccc3)nc2-c2ccccc2)cc1 CHEMBL2426399 IC50 50.0 nM
CC[C@@H](C)n1c2cnccc2c2cnc(Nc3ccc(N4CC[C@@H](O)C4)cn3)nc21 CHEMBL3702222 IC50 50.0 nM
Fc1nccc2c3cnc(Nc4ccc(CN5CCNCC5)cn4)nc3n(C3CCCC3)c12 CHEMBL3702115 IC50 52.0 nM
OCCCn1c2cnccc2c2cnc(Nc3ccc(N4CCNCC4)nn3)nc21 CHEMBL3641911 IC50 53.0 nM
c1cc2c3cnc(Nc4ccc(N5CCNCC5)cn4)nc3n(C3CCOCC3)c2cn1 CHEMBL3698656 IC50 57.0 nM
O[C@@H]1CCC[C@@H]1n1c2cnccc2c2cnc(Nc3ccc(N4CCNCC4)cn3)nc21 CHEMBL3641920 IC50 58.0 nM
CC[C@@H](C)n1c2cnccc2c2cnc(Nc3ccc(N4CCC(N(C)C)CC4)nn3)nc21 CHEMBL3702216 IC50 59.0 nM
c1cc(-c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)ccn1 CHEMBL3702162 IC50 60.0 nM
C1=C(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)CCNC1 CHEMBL3702157 IC50 60.0 nM
CCN(CC)c1cnc2ccc(-c3nc(Nc4ccc(C(=O)N5CCNCC5)cn4)ncc3F)cc2n1 CHEMBL5083405 IC50 60.0 nM
C[C@H](C1CCCCC1)n1c2cnccc2c2cnc(Nc3ccc(N4CCNCC4)cn3)nc21 CHEMBL3698663 IC50 61.0 nM
O=C(Nc1ccccn1)Nc1cccc2c1[C@H]1CCCN1C2=O CHEMBL141247 IC50 71.0 nM
O=S1(=O)CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CC1 CHEMBL3698697 IC50 73.0 nM
Cc1ccc(/C=N/n2c(S)nnc2-c2c[nH]c3ccccc23)cc1 CHEMBL5411451 IC50 75.0 nM
CC[C@@H](C)n1c2cnccc2c2cnc(Nc3ccc(N4CCNC(C)(C)C4)cn3)nc21 CHEMBL3702242 IC50 77.0 nM
Cc1nc(Nc2c[nH]nc2C(=O)Nc2ccc(N3CCNCC3)cc2)c2ccsc2n1 CHEMBL4164331 IC50 84.31 nM
CN(C)CCCN(C)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nn1 CHEMBL3702190 IC50 85.0 nM
Fc1cnc(Nc2ccc(N3CCNCC3)cn2)nc1-c1ccc2ncc(N3CCOCC3)nc2c1 CHEMBL5077663 IC50 85.0 nM
O[C@@H]1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCC5)c4n3)nc2)C1 CHEMBL3641991 IC50 92.0 nM
Oc1ccc(/C=N/n2c(S)nnc2-c2c[nH]c3ccccc23)c(O)c1 CHEMBL5440583 IC50 95.0 nM
CN(C)c1cnc2ccc(-c3nc(Nc4ccc(N5CCNCC5)cn4)ncc3F)cc2n1 CHEMBL5089915 IC50 97.0 nM
c1cc(-c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)ccn1 CHEMBL3702161 IC50 101.0 nM
NC1[C@H]2CN(c3ccc(Nc4ncc5c6ccncc6n(C6CCCC6)c5n4)nn3)C[C@@H]12 CHEMBL3702174 IC50 101.0 nM
COc1ccc(F)cc1-c1c(F)cnc2[nH]c(C3=CCN([C@H]4CC[C@H](C(=O)O)CC4)CC3)cc12 CHEMBL4777981 IC50 101.0 nM
CN(C)C1CCN(c2ccc(Nc3ncc4c5ccncc5n(CCCO)c4n3)nc2)CC1 CHEMBL3641909 IC50 102.0 nM
CN(C)c1cnc2ccc(-c3nc(Nc4ccc(C(=O)N5CCNCC5)cn4)ncc3F)cc2n1 CHEMBL5081489 IC50 102.0 nM
OCCCn1c2cnccc2c2cnc(Nc3ccc(N4CC[C@@H](O)C4)nn3)nc21 CHEMBL3641912 IC50 103.0 nM
Oc1ccc2c3cnc(Nc4ccc(N5CCNCC5)cn4)nc3n(C3CCCC3)c2n1 CHEMBL3702088 IC50 104.0 nM
CCC(CC)n1c2cnccc2c2cnc(Nc3ccc(N4CC[C@@H](O)C4)nn3)nc21 CHEMBL3702069 IC50 110.0 nM
O[C@H]1CCN(c2ccc(Nc3ncc4c5ccccc5n(C5CCCC5)c4n3)nc2)C1 CHEMBL3702205 IC50 111.0 nM
O=C(c1cnc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)s1)N1CCNCC1 CHEMBL3698685 IC50 112.0 nM
c1cc2c3cnc(Nc4ccc(N5CCNCC5)cn4)cc3n(C3CCCC3)c2cn1 CHEMBL3702138 IC50 112.0 nM
Fc1cnc(Nc2ccc(N3CCNCC3)cn2)nc1-c1ccc2nccnc2c1 CHEMBL5082230 IC50 118.0 nM
CC(C)N1CCN(C(=O)c2ccc(Nc3ncc(F)c(-c4ccc5ncc(N(C)C)nc5c4)n3)nc2)CC1 CHEMBL5077271 IC50 118.0 nM
O=C(Nc1ccc(N2CCNCC2)cc1)c1n[nH]cc1Nc1cc(Oc2ccccc2)ncn1 CHEMBL5401158 IC50 121.6 nM
O=C(Nc1ccc(N2CCNCC2)cc1)c1n[nH]cc1Nc1cc(C2CC2)ncn1 CHEMBL5415967 IC50 125.31 nM
CC(C)(CO)Cn1c2cnccc2c2cnc(Nc3ccc(N4CCNCC4)cn3)nc21 CHEMBL3698680 IC50 129.0 nM
CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1 CHEMBL1336 IC50 130.0 nM
c1csc(Cn2c3cnccc3c3cnc(Nc4ccc(N5CCNCC5)cn4)cc32)c1 CHEMBL3702139 IC50 131.0 nM
O=C(Nc1c[nH]nc1-c1nc2ccc(CN3CCOCC3)cc2[nH]1)NC1CC1 CHEMBL495727 Kd apparent 140.0 nM
CC(C)(C)c1cnc(CSc2cnc(NC(=O)C3CCNCC3)s2)o1 CHEMBL296468 Kd apparent 142.0 nM
Sc1nnc(-c2c[nH]c3ccccc23)n1/N=C/c1cccc(Br)c1 CHEMBL5426856 IC50 146.0 nM
Cn1c(=O)ccc2c3cnc(Nc4ccc(N5CC[C@@H](O)C5)cn4)nc3n(C3CCCC3)c21 CHEMBL3702090 IC50 149.0 nM
CN(C)C1CCN(c2ccc(Nc3ncc4c5ccnc(F)c5n(CC5CC5)c4n3)nn2)CC1 CHEMBL3702076 IC50 150.0 nM
O=C(Nc1ccc(N2CCNCC2)cc1)c1n[nH]cc1Nc1cc(OC2CCCC2)ncn1 CHEMBL5435746 IC50 158.01 nM
CCN(CC)c1cnc2ccc(-c3nc(Nc4ccc(C(=O)N5CCN(C(C)C)CC5)cn4)ncc3F)cc2n1 CHEMBL5076627 IC50 174.0 nM
O=C(c1ccc(Nc2ncc(F)c(-c3ccc4ncc(N5CCOCC5)nc4c3)n2)nc1)N1CCNCC1 CHEMBL5085896 IC50 175.0 nM
C[C@H]1CN(c2ccc(Nc3ncc4c5ccncc5n(CCCO)c4n3)nc2)CCN1 CHEMBL3641910 IC50 176.0 nM
O=C(O)Cc1ccc(-n2c3cnccc3c3cnc(Nc4ccc(N5CCNCC5)cn4)cc32)cc1 CHEMBL3702140 IC50 178.0 nM
CCN1CCN(Cc2ccc(Nc3ncc(F)c(-c4cc(F)c5nc6n(c5c4)C(C)CC6)n3)nc2C)CC1 CHEMBL4215126 IC50 178.0 nM
COc1ccc(/C=N/n2c(S)nnc2-c2c[nH]c3ccccc23)cc1OC CHEMBL5411462 IC50 198.0 nM
O=C(c1ccc(Nc2ncc(F)c(-c3ccc4nccnc4c3)n2)nc1)N1CCNCC1 CHEMBL5088816 IC50 199.0 nM
COc1cc(/C=N/n2c(S)nnc2-c2c[nH]c3ccccc23)cc(OC)c1OC CHEMBL5401951 IC50 200.0 nM
Cc1nc2ccc(-c3nc(Nc4ccc(N5CCNCC5)cn4)ncc3F)cc2nc1C CHEMBL5090931 IC50 204.0 nM
CN1CC[C@@H](c2c(O)cc(O)c3c(=O)cc(-c4ccc(C(F)(F)F)cc4Cl)oc23)[C@@H]1CO CHEMBL3905910 IC50 210.0 nM
Oc1cc2c3cnc(Nc4ccc(N5CCNCC5)cn4)nc3n(C3CCCC3)c2cn1 CHEMBL3698678 IC50 218.0 nM
Sc1nnc(-c2c[nH]c3ccccc23)n1/N=C/c1ccc(Cl)cc1 CHEMBL5396524 IC50 235.0 nM
CN[C@H]1CC2OC([C@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(O)=NC4 CHEMBL3975634 IC50 242.6 nM
CCN1CCN(Cc2ccc(Nc3ncc(F)c(-c4cc(F)c5nc6n(c5c4)CCC6)n3)nc2)CC1 CHEMBL4214566 IC50 244.1 nM
CCN1CCN(Cc2ccc(Nc3ncc(F)c(-c4cc(F)c5nc6n(c5c4)CCCCC6)n3)nc2)CC1 CHEMBL4204961 IC50 247.8 nM
Nc1ccc(Oc2ccc(NC(=O)Nc3cccc(C(F)(F)F)c3)cc2)cn1 CHEMBL5190752 IC50 251.3 nM
c1cc2c3cnc(Nc4ccc(N5CCNCC5)cn4)cc3n(Cc3ccsc3)c2cn1 CHEMBL3702137 IC50 257.0 nM
CCN(CC)c1cnc2ccc(-c3nc(Nc4ccc(CN5CCN(C(C)C)CC5)cn4)ncc3F)cc2n1 CHEMBL5093528 IC50 258.0 nM
Cc1nc(Nc2ncc(F)c(-c3cc(F)c4nc5n(c4c3)C(C)(C)CC5)n2)ccc1CN1CCN(C)CC1 CHEMBL4216447 IC50 271.0 nM
Sc1nnc(-c2c[nH]c3ccccc23)n1/N=C/c1ccc(Cl)cc1Cl CHEMBL5419338 IC50 271.0 nM
CCN1CCN(C(=O)c2ccc(Nc3ncc(F)c(-c4ccc5ncc(N(CC)CC)nc5c4)n3)nc2)CC1 CHEMBL5081007 IC50 272.0 nM
CN(C)C1CCN(c2ccc(Nc3ncc4c5ccncc5n([C@H]5CCC[C@H]5O)c4n3)nn2)CC1 CHEMBL3641914 IC50 275.0 nM
CC1CCc2nc3c(F)cc(-c4nc(Nc5ccc(CN6CCN(C)CC6)cn5)ncc4F)cc3n21 CHEMBL4209318 IC50 275.0 nM
CNc1nc(C)c(-c2nc(Nc3ccc(N4CCC(N(C)C)CC4)cn3)ncc2F)s1 CHEMBL5287062 Ki 279.0 nM
CN1CCN(C(=O)c2ccc(Nc3ncc(F)c(-c4ccc5nccnc5c4)n3)nc2)CC1 CHEMBL5082257 IC50 282.0 nM
COc1ccc(F)cc1-c1ccnc2[nH]c(C3=CCN(CC(O)CO)CC3)cc12 CHEMBL3668457 IC50 298.0 nM
CCN(CC)c1cnc2ccc(-c3nc(Nc4ccc(N5CCN(C)CC5)cn4)ncc3F)cc2n1 CHEMBL5089214 IC50 306.0 nM
CC(C)N1CCN(C(=O)c2ccc(Nc3ncc(F)c(-c4ccc5nccnc5c4)n3)nc2)CC1 CHEMBL5078670 IC50 308.0 nM
C[C@@H](O)Cn1c2cnccc2c2cnc(Nc3ccc(N4CCC(N(C)C)CC4)cn3)nc21 CHEMBL3641916 IC50 314.0 nM
CC(C)N1CCN(Cc2ccc(Nc3ncc(F)c(-c4ccc5nccnc5c4)n3)nc2)CC1 CHEMBL5085873 IC50 315.0 nM
CC(C)(C)c1nc(-c2cccc(NS(=O)(=O)c3c(F)cccc3F)c2F)c(-c2ccnc(N)n2)s1 CHEMBL2028663 Kd apparent 318.0 nM
CCC1Cc2nc3c(F)cc(-c4nc(Nc5ccc(CN6CCN(CC)CC6)cn5)ncc4F)cc3n2C1 CHEMBL4213109 IC50 339.0 nM
CN(C)C1CCN(c2ccc(Nc3ncc4c5ccncc5n([C@@H]5CCNC5)c4n3)nc2)CC1 CHEMBL3641908 IC50 340.0 nM
O[C@H]1CCN(C2CCN(c3ccc(Nc4ncc5c6ccncc6n(C6CCCC6)c5n4)nc3)CC2)C1 CHEMBL3642017 IC50 350.0 nM
CS(=O)(=O)N1CCN(Cc2ccc(Nc3ncc(F)c(-c4ccc5nccnc5c4)n3)nc2)CC1 CHEMBL5093557 IC50 351.0 nM
COc1ccc(-c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)cn1 CHEMBL3702163 IC50 360.0 nM
CC(=O)N[C@@H]1CCC[C@H](C(=O)Nc2cc(-c3cnn4c3CC(C)(C)C4)c(Cl)cn2)C1 CHEMBL4462530 IC50 363.0 nM
C[C@@H](O)Cn1c2cnccc2c2cnc(Nc3ccc(N4CCNCC4)cn3)nc21 CHEMBL3641915 IC50 370.0 nM
FC(F)(F)CNC1CCN(c2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nn2)CC1 CHEMBL3642012 IC50 380.0 nM
CCN1CCN(Cc2ccc(Nc3ncc(F)c(-c4cc(F)c5nc6n(c5c4)CC(C)C6)n3)nc2)CC1 CHEMBL4215568 IC50 392.0 nM
c1cc2c3cnc(Nc4ccc(NCC5CNC5)nn4)nc3n(C3CCCC3)c2cn1 CHEMBL3698727 IC50 396.0 nM
COC(=O)[C@@]1(O)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL281948 Kd apparent 399.0 nM
COCCn1c2cnccc2c2cnc(Nc3ccc(N4CCNCC4)nn3)nc21 CHEMBL3702213 IC50 400.0 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL388978 IC50 402.0 nM
Cc1cc(N2CCNCC2)cnc1Nc1ncc2c3ccncc3n(C3CCCC3)c2n1 CHEMBL3698686 IC50 406.0 nM
Sc1nnc(-c2c[nH]c3ccccc23)n1/N=C/c1ccc(Br)cc1 CHEMBL5418155 IC50 462.0 nM
COc1cc2c3cnc(Nc4ccc(N5CCNCC5)cn4)nc3n(C3CCCC3)c2cn1 CHEMBL3698677 IC50 500.0 nM
COc1cc2c3cnc(Nc4ccc(N5CCNCC5)cn4)nc3n(C3CCCC3)c2nn1 CHEMBL3702106 IC50 520.0 nM
CN(C)c1cnc2ccc(-c3ccnc(Nc4ccc(N5CCNCC5)cn4)n3)cc2n1 CHEMBL5081097 IC50 524.0 nM
CC(=O)N[C@@H]1CCC[C@H](C(=O)Nc2cc(-c3cnn4c3CC(C)(C)C4)c(F)cn2)C1 CHEMBL4754081 IC50 532.0 nM
Cc1nc2ccc(-c3nc(Nc4ccc(C(=O)N5CCN(C(C)C)CC5)cn4)ncc3F)cc2nc1C CHEMBL5080781 IC50 544.0 nM
COc1ccc(/C=N/n2c(S)nnc2-c2c[nH]c3ccccc23)cc1 CHEMBL5431823 IC50 574.0 nM
Sc1nnc(-c2c[nH]c3ccccc23)n1/N=C/c1ccccc1 CHEMBL5407831 IC50 577.0 nM
C[C@@H](O)Cn1c2cnccc2c2cnc(Nc3ccc(N4CC[C@@H](O)C4)cn3)nc21 CHEMBL3641917 IC50 590.0 nM
CCN1CCN(Cc2ccc(Nc3ncc(F)c(-c4ccc5nc(C)c(C)nc5c4)n3)nc2)CC1 CHEMBL5088870 IC50 611.0 nM
CC(C)N1CCN(C(=O)c2ccc(Nc3ncc(F)c(-c4ccc5ncc(N6CCOCC6)nc5c4)n3)nc2)CC1 CHEMBL5079586 IC50 611.0 nM
COc1cnc(Nc2ccc(N3CCNCC3)cn2)nc1-c1ccc2ncc(N(C)C)nc2c1 CHEMBL5094319 IC50 646.0 nM
CCN1CCN(Cc2ccc(Nc3nccc(-c4cc(F)c5nc6n(c5c4)C(C)CC6)n3)nc2)CC1 CHEMBL4207966 IC50 752.0 nM
Oc1cccc(/C=N/n2c(S)nnc2-c2c[nH]c3ccccc23)c1O CHEMBL5401495 IC50 770.0 nM
Cc1nc2ccc(-c3nc(Nc4ccc(CN5CCN(C(C)C)CC5)cn4)ncc3F)cc2nc1C CHEMBL5073277 IC50 781.0 nM
COCCn1c2cnccc2c2cnc(Nc3ccc(N4CCNCC4)cn3)nc21 CHEMBL3702212 IC50 790.0 nM
Oc1ccc(/C=N/n2c(S)nnc2-c2c[nH]c3ccccc23)cc1 CHEMBL5439029 IC50 817.0 nM
CN(C)C1CCN(c2ccc(Nc3ncc4c5ccncc5n([C@H]5CCC[C@H]5O)c4n3)nc2)CC1 CHEMBL3641913 IC50 830.0 nM
O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)ccc12 CHEMBL31574 IC50 850.0 nM
O=C(O)c1ccc(Nc2ncc3c4ccnc(O)c4n(C4CCCC4)c3n2)nc1 CHEMBL3702126 IC50 860.0 nM
C=CC(=O)Nc1ccc(C(=O)Nc2n[nH]c3ccc(-c4cncc(NC[C@@H](O)c5ccccc5)c4)cc23)cc1 CHEMBL5288241 IC50 950.0 nM
CN1C(=O)[C@@H](N2CCc3cn(Cc4ccccc4)nc3C2=O)COc2ccccc21 CHEMBL4088216 pIC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3c(nn(Cc4ccccc4)c3Br)C2=O)COc2ccccc21 CHEMBL4549667 pIC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3cn(CC4CCS(=O)(=O)CC4)nc3C2=O)COc2ccccc21 CHEMBL4097778 pIC50 1000.0 nM
Cc1nc2ccc(-c3nc(Nc4ccc(C(=O)N5CCN(C)CC5)cn4)ncc3F)cc2nc1C CHEMBL5093550 IC50 1000.0 nM