CNC(=O)c1ccc2cncc(-c3ccc(-c4cnn(C)c4)cc3)c2n1 CHEMBL3827983 IC50 0.2 nM
COCCNC(=O)c1ccc(Oc2sc(C(N)=O)c3c2-c2sncc2CC3)c(C)n1 CHEMBL4071040 EC50 0.35 nM
CC(=O)Nc1ccc(Oc2sc(C(N)=O)c3c2-c2sncc2CC3)cn1 CHEMBL4086487 EC50 0.4 nM
Cn1cc(-c2ccc(-c3cncc4ccc(C(N)=O)nc34)cc2)cn1 CHEMBL3828116 IC50 0.5 nM
CNc1ccc(Oc2sc(C(N)=O)c3c2-c2sncc2CC3)cn1 CHEMBL4061525 EC50 0.58 nM
CNC(=O)c1ccc2cncc(-c3ccc(-c4cnn(C)c4)cc3)c2c1 CHEMBL3828003 IC50 0.6 nM
Cc1n[nH]c2ccc(C(=O)N3CCC[C@H]3c3ccc(Cl)cc3)cc12 CHEMBL3956719 IC50 0.6 nM
NC(=O)c1sc(Oc2ccccc2)c2c1CCc1cnsc1-2 CHEMBL4083552 EC50 0.77 nM
CN(C)C(=O)Cn1cc(-c2ccc(-c3cncc4ccccc34)cc2)cn1 CHEMBL4455382 Kd 0.77 nM
OC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1986943 pKi 0.7943 nM
CNC(=O)c1ccc2cncc(-c3ccc4c(c3)CS(=O)(=O)N4C)c2n1 CHEMBL3828637 IC50 0.9 nM
Cc1ccc(F)c(NC(=O)Nc2ccc(-c3cccc4[nH]nc(N)c34)cc2)c1 CHEMBL223360 pKi 1.0 nM
Cn1cc(-c2ccc(-c3cncc4ccc(C(=O)NC5CC5)cc34)cc2)cn1 CHEMBL3827327 IC50 1.1 nM
Nc1nc(Cl)cc(-c2c[nH]c3ncccc23)n1 CHEMBL2007574 pKi 1.259 nM
COCCNC(=O)c1ccc(Oc2sc(C(N)=O)c3c2-c2sncc2CC3)cn1 CHEMBL4066819 EC50 1.3 nM
CCN1CCN(Cc2ccc(NC(=O)Nc3ccc(Oc4cc(NC)ncn4)cc3)cc2C(F)(F)F)CC1 CHEMBL574738 Kd 1.4 nM
NC(=O)c1ccc(Oc2sc(C(N)=O)c3c2-c2sncc2CC3)cn1 CHEMBL4060856 EC50 1.4 nM
CCOCCNC(=O)c1ccc(Oc2sc(C(N)=O)c3c2-c2sncc2CC3)cn1 CHEMBL4077627 EC50 1.5 nM
CCn1c(C(N)=O)cc2c1-c1ccncc1OC2(C)C CHEMBL4791276 IC50 1.5 nM
CS(=O)(=O)NCCNc1cc(-c2c[nH]c3ncccc23)cc(Cl)n1 CHEMBL2005718 pKi 1.585 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4cccc(Cl)c4)c3)cc12 CHEMBL1974870 pKi 1.585 nM
O=C(Nc1cccc(Cl)c1)Nc1ncc(CCNc2ncnc3ccsc23)s1 CHEMBL482767 pKi 1.585 nM
CN(C)CC(=O)NC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1982271 pKi 1.585 nM
CNCC(=O)NC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1996980 pKi 1.585 nM
CC(C)(O)Cn1cc(-c2ccc(-c3cncc(Cl)c3N3CCC4(CCNC4=O)CC3)cc2)cn1 CHEMBL3798944 IC50 1.6 nM
Nc1n[nH]c2cc(-c3cncc(Cl)c3N3CCC4(CCNC4=O)CC3)ccc12 CHEMBL3797855 IC50 1.7 nM
CN1c2ccc(-c3cnc(N)c(Cl)c3N3CCC4(CC3)CNC(=O)O4)cc2CS1(=O)=O CHEMBL3798853 IC50 1.9 nM
CN(C)C1CCCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)C1 CHEMBL1965702 pKi 1.995 nM
Nc1c(-c2ccc(NC(=O)Nc3cccc(C(F)(F)F)c3)cc2)ccc2nccnc12 CHEMBL2004438 pKi 1.995 nM
CN1CCC(c2c(O)cc(O)c3c(=O)cc(-c4ccccc4Cl)oc23)C(O)C1 CHEMBL422897 pKi 1.995 nM
Cn1cc(-c2ccc(-c3cncc4ccc(C(=O)N5CCC5)nc34)cc2)cn1 CHEMBL3827799 IC50 2.0 nM
Cc1n[nH]c2ccc(C(=O)N3CC[C@H]3c3ccc(Cl)cc3)cc12 CHEMBL3966985 IC50 2.0 nM
Cc1ncccc1Oc1sc(C(N)=O)c2c1-c1sncc1CC2 CHEMBL4070408 EC50 2.0 nM
Cn1ncc2cc(-c3cnc4[nH]nc(Cl)c4c3N3CCC4(CCNC4=O)CC3)ccc21 CHEMBL4877883 IC50 2.0 nM
Nc1ncc(-c2ccc3c(N)n[nH]c3c2)c(N2CCC3(CCNC3=O)CC2)c1Cl CHEMBL3799581 IC50 2.1 nM
CN1c2ccc(-c3cncc(Cl)c3N3CCC4(CC3)CNC(=O)O4)cc2CS1(=O)=O CHEMBL3799307 IC50 2.3 nM
CN1c2ccc(-c3cnc(N)c(Cl)c3N3CCC4(CCNC4=O)CC3)cc2CS1(=O)=O CHEMBL3799212 IC50 2.3 nM
Cn1ncc2cc(-c3cnc(N)c(Cl)c3N3CCC4(CCNC4=O)CC3)ccc21 CHEMBL3798382 IC50 2.3 nM
O=C(/C=C/c1cncc(F)c1-c1cnn(C2CC2)c1)Nc1ccc(CN2CCOCC2)cc1 CHEMBL4060759 EC50 2.3 nM
NC(=O)c1sc(Oc2ccc(N)nc2)c2c1CCc1cnsc1-2 CHEMBL4074204 EC50 2.3 nM
O=C1NCCC12CCN(c1c(Cl)cncc1-c1ccc3c(c1)CS(=O)(=O)N3)CC2 CHEMBL3800311 IC50 2.4 nM
CN1c2ccc(-c3cncc(Cl)c3N3CCC4(CCNC4=O)CC3)cc2CS1(=O)=O CHEMBL3797571 IC50 2.4 nM
CN1c2ccc(-c3cncc(Cl)c3N3CCC4(CC3)NC(=O)NC4=O)cc2CS1(=O)=O CHEMBL3798987 IC50 2.4 nM
Cn1cnc2ccc(-c3ccncc3/C=C/C(=O)Nc3ccc(CN4CCOCC4)cc3)cc21 CHEMBL4072106 EC50 2.4 nM
COC1CN(C(=O)c2ccc3cncc(-c4ccc(-c5cnn(C)c5)cc4)c3n2)C1 CHEMBL3827118 IC50 2.5 nM
NC(=O)c1cc2c(-c3ccc(Br)cc3)cncc2s1 CHEMBL1978195 pKi 2.512 nM
NC(=O)c1cc2c(-c3ccc(Nc4nc5ccccc5o4)cc3)cnc(N)c2s1 CHEMBL1993904 pKi 2.512 nM
CNC(=O)c1ccc(Oc2sc(C(N)=O)c3c2-c2sncc2CC3)cn1 CHEMBL4076395 EC50 2.6 nM
Cc1n[nH]c2ncc(C(=O)N3CCC[C@H]3c3ccc(Cl)cc3)cc12 CHEMBL3903492 IC50 2.6 nM
CC1=NNC(=O)C12CCN(c1c(Cl)cncc1-c1ccc3c(c1)CS(=O)(=O)N3C)CC2 CHEMBL3799396 IC50 2.7 nM
Cn1cc(-c2ccc(-c3cnc(N)c(Cl)c3N3CCC4(CC3)NC(=O)NC4=O)cc2)cn1 CHEMBL3798804 IC50 2.8 nM
CNc1n[nH]c2cc(-c3cncc(Cl)c3N3CCC4(CCNC4=O)CC3)ccc12 CHEMBL3799824 IC50 2.8 nM
Cc1n[nH]c2ccc(C(=O)N3CCC[C@H]3c3ccc(Cl)cc3)nc12 CHEMBL3947140 IC50 2.8 nM
Cc1ccc(Oc2sc(C(N)=O)c3c2-c2sncc2CC3)cn1 CHEMBL4062244 EC50 3.0 nM
NC(=O)c1sc(Oc2cccnc2)c2c1CCc1cnsc1-2 CHEMBL4091345 EC50 3.0 nM
CN1CCN(Cc2ccc(NC(=O)Nc3ccc(Oc4ccnc(N)n4)cc3)cc2C(F)(F)F)CC1 CHEMBL4472486 IC50 3.0 nM
O=C(/C=C/c1cnccc1-c1cnn(C2CC2)c1)Nc1ccc(CN2CC3CC2CO3)cc1 CHEMBL4063908 EC50 3.1 nM
CC(=O)NC1CCCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)C1 CHEMBL1980178 pKi 3.162 nM
Cn1nc(N)c2ccc(-c3cncc(Cl)c3N3CCC4(CCNC4=O)CC3)cc21 CHEMBL3799592 IC50 3.2 nM
CN1c2ccc(-c3cncc(C(F)(F)F)c3N3CCC4(CCNC4=O)CC3)cc2CS1(=O)=O CHEMBL3798726 IC50 3.3 nM
CN1c2ccc(-c3cnc(N)c(F)c3N3CCC4(CCNC4=O)CC3)cc2CS1(=O)=O CHEMBL3797440 IC50 3.3 nM
CNC(=O)c1ccc2cncc(-c3ccc4c(cnn4C)c3)c2n1 CHEMBL3827774 IC50 3.4 nM
CCc1cnn2c(NCc3ccc[n+]([O-])c3)cc(N3CCCC[C@H]3CCO)nc12 CHEMBL2103840 IC50 3.4 nM
CN(C)[C@@H]1CC[C@@]2(C)[C@@H](CC[C@@H]3[C@@H]2CC[C@]2(C)C(c4cccc5cnccc45)=CC[C@@H]32)C1 CHEMBL4637601 Kd 3.5 nM
Cn1cc(-c2c(F)cncc2/C=C/C(=O)Nc2ccc(CN3CCOCC3)cc2)cn1 CHEMBL4081088 EC50 3.6 nM
CN1c2cc(-c3cncc(Cl)c3N3CCC4(CCNC4=O)CC3)ccc2CS1(=O)=O CHEMBL3797317 IC50 3.7 nM
CN1c2ccc(-c3cncc(F)c3N3CCC4(CCNC4=O)CC3)cc2CS1(=O)=O CHEMBL3799116 IC50 3.8 nM
Cn1cc(-c2ccc(-c3cncc(Cl)c3N3CCC4(CC3)NCNC4=O)cc2)cn1 CHEMBL3798632 IC50 3.9 nM
Clc1cc(-c2c[nH]c3ncccc23)nc(NC2CCCCC2)n1 CHEMBL2006439 pKi 3.981 nM
CC(C)CNC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL2006456 pKi 3.981 nM
Cn1cc(-c2ccc(-c3cncc(Cl)c3N3CCC4(CC3)NC(=O)CNC4=O)cc2)cn1 CHEMBL3799679 IC50 4.2 nM
Cn1cc(-c2ccc(-c3cncc4ccc(N5CCNC5=O)nc34)cc2)cn1 CHEMBL3828458 IC50 4.2 nM
CN1c2ccc(-c3cncc(F)c3N3CCC4(CC3)CNC(=O)O4)cc2CS1(=O)=O CHEMBL3800037 IC50 4.3 nM
Cc1c(Br)c(Br)c2c3c1nc(N1CCNCC1)n3CCC2 CHEMBL4578881 IC50 4.4 nM
Cc1c(Br)c(Br)c2c3c1nc(N1CCNCC1)n3CCC2 CHEMBL4225966 IC50 4.4 nM
CC1=NC2(CCN(c3c(Cl)cncc3-c3ccc4c(c3)CS(=O)(=O)N4C)CC2)C(=O)N1 CHEMBL3797495 IC50 4.5 nM
Cc1cc(Oc2ccc(CCCC(=O)N(C)C)cc2F)c2c(N)c(C(N)=O)sc2n1 CHEMBL4442570 IC50 4.5 nM
CNC(=O)c1ccc2cncc(-c3ccc4cnn(C)c4c3)c2n1 CHEMBL3828209 IC50 4.6 nM
Cn1cc(-c2ccc(-c3cncc4ccc(-c5nccn5C)nc34)cc2)cn1 CHEMBL3828221 IC50 4.7 nM
Cn1cc(-c2ccc(-c3cncc4ccc(N5CCOC5=O)cc34)cc2)cn1 CHEMBL3828503 IC50 4.7 nM
Cn1cc(-c2ccc(Cc3n[nH]c4ccc(C(=O)N5CCCC5)cc34)cc2)cn1 CHEMBL3775935 IC50 5.0 nM
Cn1cc(-c2ccc(-c3cnc(N)c(Cl)c3N3CCC4(CCNC4=O)CC3)cc2)cn1 CHEMBL3797558 IC50 5.0 nM
CNC(=O)c1ccc2[nH]nc(Cc3ccc(-c4cnn(C)c4)cc3)c2c1 CHEMBL3775535 IC50 5.0 nM
NC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1973720 pKi 5.012 nM
O=C1NCCC12CCN(c1c(Cl)cncc1-c1ccc(-c3cnn(CCO)c3)cc1)CC2 CHEMBL3798663 IC50 5.5 nM
CN1c2ccc(-c3cnc(N)c(F)c3N3CCC4(CC3)CNC(=O)O4)cc2CS1(=O)=O CHEMBL3797656 IC50 5.5 nM
O=C(/C=C/c1cnccc1-c1cnn(C2CC2)c1)Nc1ccc(CN2CC3CC(C2)O3)cc1 CHEMBL4079977 EC50 5.5 nM
CN1CNC(=O)C12CCN(c1c(Cl)cncc1-c1ccc(-c3cnn(C)c3)cc1)CC2 CHEMBL3800080 IC50 5.7 nM
Cn1cc(-c2ccc(-c3cnc(N)c4ccc(C(=O)N5CC(F)(F)C5)nc34)cc2)cn1 CHEMBL3828071 IC50 5.8 nM
Cn1cc(-c2ccc(-c3cncc(Cl)c3N3CCC4(CC3)NC(=O)NC4=O)cc2)cn1 CHEMBL3800210 IC50 7.0 nM
Cn1cc(-c2ccncc2/C=C/C(=O)Nc2ccc3c(c2)CCN(CC(F)(F)F)C3)cn1 CHEMBL4060561 EC50 7.0 nM
Cn1cc(-c2ccc(-c3cncc(Cl)c3N3CCC4(CCNC4=O)CC3)cc2)cn1 CHEMBL3408213 IC50 7.2 nM
COC1CN(C(=O)c2ccc3c(N)ncc(-c4ccc(-c5cnn(C)c5)cc4)c3n2)C1 CHEMBL3828553 IC50 7.2 nM
Cn1cc(-c2ccc(-c3cncc4ccc(-c5nccn5C)cc34)cc2)cn1 CHEMBL3827678 IC50 7.3 nM
CC(C)(O)CNC(=O)c1ccc(Oc2sc(C(N)=O)c3c2-c2sncc2CC3)cn1 CHEMBL4090775 EC50 7.4 nM
CC(Nc1cncc(-n2cnc3ccc(C#N)cc32)n1)c1ccccc1F CHEMBL1977138 pKi 7.943 nM
O=C(Nc1cccc(Cl)c1)Nc1nc(CCNc2ncnc3ccsc23)cs1 CHEMBL1986177 pKi 7.943 nM
Cc1ccc(F)c(NC(=O)Nc2ccc(-c3coc4c(C#CCN5CCOCC5)cnc(N)c34)cc2)c1 CHEMBL1983640 pKi 7.943 nM
CCCC(=O)Nc1cc(-c2c[nH]c3ncccc23)cc(Cl)n1 CHEMBL1998470 pKi 7.943 nM
COC1(C)CN(C(=O)c2ccc3c(N)ncc(-c4ccc(-c5cnn(C)c5)cc4)c3n2)C1 CHEMBL3827023 IC50 8.2 nM
O=C(Nc1ccc2c(c1)Oc1ncccc1C(=O)N2c1ccncc1)Nc1ccc(Cl)c(C(F)(F)F)c1 CHEMBL4792974 IC50 8.25 nM
Cc1c(Oc2sc(C(N)=O)c3c2-c2sncc2CC3)ccc[n+]1[O-] CHEMBL4088931 EC50 8.3 nM
O=C(/C=C/c1cnccc1-c1cnn(C2CC2)c1)Nc1ccc(CN2CC(F)(F)C2)cc1 CHEMBL4059523 EC50 8.4 nM
Cn1cc(-c2ccncc2/C=C/C(=O)Nc2ccc3c(c2)CN(CC(F)(F)F)CC3)cn1 CHEMBL4069244 EC50 8.4 nM
CSc1sc(C(N)=O)c2c1-c1sncc1CC2 CHEMBL4082469 EC50 8.9 nM
COC1CN(C(=O)c2ccc3[nH]nc(Cc4ccc(-c5cnn(C)c5)cc4)c3c2)C1 CHEMBL3774402 IC50 9.0 nM
Cn1cc(-c2ccc(-c3cnc(N)c4ccc(C(=O)NC5CC5)cc34)cc2)cn1 CHEMBL3827664 IC50 9.0 nM
COc1sc(C(N)=O)c2c1-c1sncc1CC2 CHEMBL4069854 EC50 9.1 nM
Cn1cc(-c2ccc(-c3cnc(N)c(C(F)(F)F)c3N3CCC4(CCNC4=O)CC3)cc2)cn1 CHEMBL3800105 IC50 9.3 nM
Cn1cc(-c2ccc(-c3cnc(N)c(Cl)c3N3CCC4(CC3)CNC(=O)O4)cc2)cn1 CHEMBL3797472 IC50 9.5 nM
Cn1cc(-c2ccc(-c3cnc(N)c4ccc(C(=O)N5CC(C)(F)C5)nc34)cc2)cn1 CHEMBL3828286 IC50 9.8 nM
Cn1cc(-c2ccc(-c3cncc4ccc(C(=O)N5CCCC5)nc34)cc2)cn1 CHEMBL3828523 IC50 9.9 nM
O=C(Nc1ccccc1)Nc1ccc2c(c1)Oc1ncccc1C(=O)N2c1ccncc1 CHEMBL4788035 IC50 9.96 nM
O=C1NCCc2[nH]c(-c3ccncc3)cc21 CHEMBL225519 pKi 10.0 nM
O=C(/C=C/c1cnccc1-c1ccc2[nH]cnc2c1)Nc1ccc(CN2CCOCC2)cc1 CHEMBL4082587 EC50 10.0 nM
CNC(=O)c1ccc2[nH]nc(Cc3ccc4c(cnn4C)c3)c2c1 CHEMBL3775576 IC50 10.0 nM
CN(C)CCC1(C#N)CCN(c2c(Cl)cncc2-c2ccc3c(c2)CS(=O)(=O)N3C)CC1 CHEMBL3798886 IC50 10.4 nM
Cn1cc(-c2ccc(-c3cnc(N)c4ccc(C(=O)N5CCC5)nc34)cc2)cn1 CHEMBL3828084 IC50 10.7 nM
Cn1cc(-c2ccc(-c3cncc(Cl)c3N3CCC4(CC3)CNC(=O)O4)cc2)cn1 CHEMBL3799742 IC50 10.8 nM
Cn1cc(-c2ccc(Cc3n[nH]c4ccc(C(=O)N5CCOCC5)cc34)cc2)cn1 CHEMBL3774885 IC50 11.0 nM
O=C(/C=C/c1cnccc1-c1cnn(C2CC2)c1)Nc1ccc(CN2CCOCC2)cc1 CHEMBL4092865 EC50 11.0 nM
O=C(/C=C/c1cnccc1-c1cnn(C(F)F)c1)Nc1ccc(CN2CCOCC2)cc1 CHEMBL4063489 EC50 11.0 nM
CNc1ncc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)c(N)n1 CHEMBL5281052 IC50 11.0 nM
CNC(=O)c1ccc2cncc(-c3ccc4c(c3)CS(=O)(=O)N4)c2n1 CHEMBL3828575 IC50 11.2 nM
Cn1ncc2cc(-c3cnc(N)c(Cl)c3N3CCC4(CC3)CNC(=O)O4)ccc21 CHEMBL3799073 IC50 11.4 nM
CN1c2ccc(-c3cncc(Cl)c3N3CCC4(CC3)C(=O)NN=C4C(F)(F)F)cc2CS1(=O)=O CHEMBL3798129 IC50 12.0 nM
CNc1n[nH]c2ccc(C(=O)N3CCC[C@H]3c3ccc(Cl)cc3)cc12 CHEMBL3895703 IC50 12.0 nM
COc1ncc(-c2ccncc2/C=C/C(=O)Nc2ccc(CN3CCOCC3)cc2)s1 CHEMBL4087219 EC50 12.0 nM
CN(C)[C@H]1C[C@@]23CC[C@@]4(O2)C(=CC[C@]2(C)[C@@H](c5ccc6ccncc6c5)CC[C@H]24)C=C3[C@@H](O)[C@@H]1O CHEMBL4080906 IC50 12.0 nM
CN(C)[C@H]1C[C@@]23CC[C@]4(O2)C(=CC[C@]2(C)[C@@H](c5ccc6ccncc6c5)CC[C@H]24)C=C3[C@@H](O)[C@@H]1O CHEMBL4639890 IC50 12.0 nM
CN1CC[C@@H](c2c(O)cc(O)c3c(=O)cc(-c4ccc(C(F)(F)F)cc4Cl)oc23)[C@@H]1CO CHEMBL3905910 IC50 12.0 nM
Cn1cc(-c2ccc(-c3cnc(N)c(C(F)(F)F)c3N3CCC4(CC3)CNC(=O)O4)cc2)cn1 CHEMBL3798568 IC50 12.1 nM
Cc1n[nH]c2cnc(-c3cncc(OCC(N)Cc4cccc(C(F)(F)F)c4)c3)cc12 CHEMBL1998159 pKi 12.59 nM
O=C(Cc1ccc(OC(F)(F)F)cc1)N1CCC2(CC1)NCCc1c2[nH]c2ccccc12 CHEMBL1996576 pKi 12.59 nM
Cc1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3-c3ccc(F)cc3)cc12 CHEMBL1972339 pKi 12.59 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4ccc(Cl)c(Cl)c4)c3)cc12 CHEMBL1991063 pKi 12.59 nM
NC1CCCCC1Nc1nc(Cl)cc(-c2c[nH]c3ncccc23)n1 CHEMBL1994438 pKi 12.59 nM
Cn1cc(-c2ccc(-c3cncc4ccc(C(=O)N5CC(F)(F)C5)nc34)cc2)cn1 CHEMBL3827053 IC50 12.6 nM
Cn1cc(-c2ccc(Cc3n[nH]c4ccc(C(=O)N5CCCCC5)cc34)cc2)cn1 CHEMBL3775384 IC50 13.0 nM
Cn1cc(-c2ccncc2/C=C/C(=O)Nc2ccc(CN3CCOCC3)cc2)cn1 CHEMBL4063709 EC50 13.0 nM
CN(C)[C@@H]1CC[C@@]2(C)[C@@H](CC[C@@H]3[C@@H]2CC[C@]2(C)C(c4cncc(Cl)c4)=CC[C@@H]32)C1 CHEMBL4648955 Kd 13.0 nM
O=C(/C=C/c1cnccc1-c1cnn(C2CC2)c1)Nc1ccc2c(c1)CCN(CC(F)(F)F)C2 CHEMBL4082444 EC50 14.0 nM
Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12 CHEMBL1171837 IC50 14.0 nM
O=C(Nc1cccc(C(F)(F)F)c1)NC1CCN(c2ccc3nncn3n2)C1 CHEMBL5271114 IC50 14.0 nM
CN1c2ccc(-c3cncc(Cl)c3N3CCC4(CC3)OC(=O)NC4(C)C)cc2CS1(=O)=O CHEMBL3800432 IC50 14.2 nM
Cn1cc(-c2ccc(-c3cncc(C(F)(F)F)c3N3CCC4(CCNC4=O)CC3)cc2)cn1 CHEMBL3797212 IC50 14.7 nM
CN(C)[C@H]1C[C@@]23CC[C@@]4(O2)C(=CC[C@@]2(C)C4CC[C@@H]2c2ccc4ccncc4c2)C=C3[C@@H](O)[C@@H]1O CHEMBL4167143 IC50 15.0 nM
Cc1cccc(Cc2n[nH]c3cc(O)c(C(=O)N4Cc5ccccc5C4)cc23)c1 CHEMBL5270493 IC50 15.0 nM
CCCCC(=O)Nc1cc(-c2c[nH]c3ncccc23)cc(Cl)n1 CHEMBL2006450 pKi 15.85 nM
NC(=O)c1cc(-c2ccnc(N)n2)[nH]c1-c1ccc(Cl)cc1Cl CHEMBL1965660 pKi 15.85 nM
CN(C)C1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1969151 pKi 15.85 nM
COC1CN(C(=O)c2ccc3cncc(-c4ccc(-c5cnn(C)c5)cc4)c3c2)C1 CHEMBL3828370 IC50 16.0 nM
Cn1cc(-c2ccc(-c3cncc4ccc(-c5ncco5)cc34)cc2)cn1 CHEMBL3828572 IC50 16.0 nM
CC1CN(Cc2ccc(NC(=O)/C=C/c3cnccc3-c3cnn(C)c3)cc2)CCO1 CHEMBL4091382 EC50 16.0 nM
Cc1ccncc1Oc1sc(C(N)=O)c2c1-c1sncc1CC2 CHEMBL4060714 EC50 16.0 nM
CN(C)[C@H]1CC[C@@]2(C)C(=CC[C@H]3[C@@H]4CC[C@H](c5ccc6ccncc6c5)[C@@]4(C)CC[C@@H]32)C1 CHEMBL4167193 IC50 16.0 nM
CC(C)(O)Cn1cc(-c2ccc(-c3cnc(N)c(Cl)c3N3CCC4(CCNC4=O)CC3)cc2)cn1 CHEMBL3798419 IC50 16.4 nM
Cn1cc(-c2ccncc2/C=C/C(=O)Nc2ccc(CN3C4CCC3COC4)cc2)cn1 CHEMBL4070459 EC50 17.0 nM
Cn1cc(-c2ccncc2/C=C/C(=O)Nc2ccc(CN3CCC(F)(F)C3)cc2)cn1 CHEMBL4098004 EC50 17.0 nM
CN(C)[C@H]1C[C@@]23CC[C@@]4(O2)C(=CC[C@]2(C)C(c5ccc6ccncc6c5)=CCC24)C=C3[C@@H](O)[C@@H]1O CHEMBL4162429 IC50 17.0 nM
CN(C)[C@H]1C[C@@]23CC[C@@]4(O2)C(=CC[C@]2(C)[C@@H](c5ccc6cnccc6c5)CC[C@H]24)C=C3[C@@H](O)[C@@H]1O CHEMBL4635162 Kd 17.0 nM
CCN1CCN(Cc2ccc(NC(=O)N[C@@H]3CCN(c4ccnc(NC)n4)C3)cc2C(F)(F)F)CC1 CHEMBL4227266 IC50 17.4 nM
CN1C(=O)NC(=O)C12CCN(c1c(Cl)cncc1-c1ccc(-c3cnn(C)c3)cc1)CC2 CHEMBL3798611 IC50 17.5 nM
CC(=O)Nc1ccc2cncc(-c3ccc(-c4cnn(C)c4)cc3)c2n1 CHEMBL3827944 IC50 17.5 nM
Cn1cc(-c2ccc(-c3cnc(N)c4ccc(C(=O)N5CC(F)(F)C5)cc34)cc2)cn1 CHEMBL3827904 IC50 17.9 nM
Cn1ncc2cc(-c3cncc(Cl)c3N3CCC4(CCNC4=O)CC3)ccc21 CHEMBL3408216 IC50 17.9 nM
COC1CN(C(=O)c2ccc3[nH]nc(Cc4ccc5c(cnn5C)c4)c3c2)C1 CHEMBL3774959 IC50 18.0 nM
CN(C)[C@@H]1CC[C@@]2(C)[C@@H](CC[C@@H]3[C@@H]2CC[C@]2(C)C(c4ccc5ccncc5c4)=CC[C@@H]32)C1 CHEMBL4637411 Kd 18.0 nM
Nc1n[nH]c2ccc(C(=O)N3CCC[C@H]3c3ccc(Br)cc3)cc12 CHEMBL3939280 IC50 19.0 nM
Cn1cc(-c2ccncc2/C=C/C(=O)Nc2ccc(CN3CC4CC3CO4)cc2)cn1 CHEMBL4066959 EC50 19.0 nM
Cn1cc(-c2ccc(-c3cncc4ccc(C(=O)N5CC(F)(F)C5)cc34)cc2)cn1 CHEMBL3828689 IC50 19.4 nM
Cc1ccc(F)c(NC(=O)Nc2ccc(-c3ccc(OCCCn4cccc4)c4[nH]nc(N)c34)cc2)c1 CHEMBL2007266 pKi 19.95 nM
Nc1ncc(-c2cnn(CCO)c2)c2scc(-c3ccc(NC(=O)Nc4ccc(OC(F)F)cc4)cc3)c12 CHEMBL1972220 pKi 19.95 nM
NCCNc1cc(-c2c[nH]c3ncccc23)cc(Cl)n1 CHEMBL1972290 pKi 19.95 nM
CNC1CC2OC(C)(C1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL1980995 pKi 19.95 nM
Cn1cc(-c2ccc(-c3cnc(N)c4ccc(C(=O)N5CC(C)(F)C5)cc34)cc2)cn1 CHEMBL3827874 IC50 20.2 nM
Cc1nc(-c2ccc(-c3cncc(Cl)c3N3CCC4(CCNC4=O)CC3)cc2)cn1C CHEMBL3798430 IC50 20.5 nM
Cn1cc(-c2ccc(-c3cncc(F)c3N3CCC4(CC3)CNC(=O)O4)cc2)cn1 CHEMBL3800307 IC50 20.6 nM
COC1CN(C(=O)c2ccc3c(N)ncc(-c4ccc(-c5cnn(C)c5)cc4)c3c2)C1 CHEMBL3827758 IC50 21.0 nM
O=C(/C=C/c1cnccc1-c1cn[nH]c1)Nc1ccc(CN2CCOCC2)cc1 CHEMBL4091527 EC50 21.0 nM
CN(C)C(=O)c1ccc(Oc2sc(C(N)=O)c3c2-c2sncc2CC3)cn1 CHEMBL4063680 EC50 21.0 nM
NC(=O)C[C@H]1CCc2sc3ncnc(O[C@H]4CC[C@H](N5CCOCC5)CC4)c3c21 CHEMBL3361254 IC50 22.0 nM
COC1(C)CN(C(=O)c2ccc3c(N)ncc(-c4ccc(-c5cnn(C)c5)cc4)c3c2)C1 CHEMBL3827586 IC50 23.1 nM
Cn1cc(-c2ccc(-c3cnc(N)c4ccc(N5CCOC5=O)cc34)cc2)cn1 CHEMBL3827605 IC50 24.0 nM
C[C@]12CC[C@H](n3ccnn3)C[C@@H]1CC[C@@H]1[C@@H]2CC[C@]2(C)[C@@H](c3ccc4ccncc4c3)CC[C@@H]12 CHEMBL4174408 IC50 24.0 nM
CN(C)[C@H]1CC[C@@]2(C)[C@@H](CC[C@@H]3[C@@H]2CC[C@]2(C)[C@@H](c4ccc5ccncc5c4)CC[C@@H]32)C1 CHEMBL4162650 IC50 24.0 nM
CN1CCN(C(=O)c2ccc3cc(CCNc4ncnc5ccc(C#N)cc45)ccc3c2)CC1 CHEMBL4076837 IC50 24.0 nM
Cc1ccc(NC(=O)CCc2cccc(-c3cnc4[nH]ccc4c3)c2)cc1C(F)(F)F CHEMBL5183704 EC50 24.0 nM
Cn1cc(-c2ccc(Cc3n[nH]c4ccc(C(=O)N5CC(F)(F)C5)cc34)cc2)cn1 CHEMBL3775134 IC50 25.0 nM
CSc1sc(C(N)=O)c2c1-c1c(cnn1C)CC2 CHEMBL4063358 EC50 25.0 nM
CC(C)(CN)CNc1cc(-c2c[nH]c3ncccc23)cc(Cl)n1 CHEMBL1985723 pKi 25.12 nM
Nc1c(-c2ccc(NC(=O)Nc3cccc(C(F)(F)F)c3)cc2)cnc2c(-c3ccc4c(c3)OCO4)cnn12 CHEMBL1977134 pKi 25.12 nM
Cc1n[nH]c2ccc(-c3cccnc3)cc12 CHEMBL1967252 pKi 25.12 nM
NC1CCCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)C1 CHEMBL1998432 pKi 25.12 nM
O=C1NCCC12CCN(c1c(Cl)cncc1-c1ccc(-c3cnn(CCN4CCCC4)c3)cc1)CC2 CHEMBL3798318 IC50 26.9 nM
Cn1cc(-c2ccc(Cc3n[nH]c4ccc(C(=O)N5CCC(F)(F)C5)cc34)cc2)cn1 CHEMBL3775773 IC50 27.0 nM
CC1COCCN1Cc1ccc(NC(=O)/C=C/c2cnccc2-c2cnn(C)c2)cc1 CHEMBL4061835 EC50 27.0 nM
Cn1cc(-c2ccc(-c3cncc4ccc(C(=O)N5CCOCC5)nc34)cc2)cn1 CHEMBL3828120 IC50 27.8 nM
CN(C)CCn1cc(-c2ccc(-c3cncc(Cl)c3N3CCC4(CCNC4=O)CC3)cc2)cn1 CHEMBL3798294 IC50 28.0 nM
Nc1n[nH]c2ccc(C(=O)N3CCC[C@H]3c3ccc(Cl)cc3)cc12 CHEMBL3911320 IC50 28.0 nM
O=C(/C=C/c1cnccc1-c1cnn(Cc2ccccc2)c1)Nc1ccc(CN2CCOCC2)cc1 CHEMBL4101552 EC50 28.0 nM
Cc1cncc(Oc2sc(C(N)=O)c3c2-c2sncc2CC3)c1 CHEMBL4072372 EC50 28.0 nM
CC(C)n1cc(-c2ccc(-c3cnc(N)c(Cl)c3N3CCC4(CCNC4=O)CC3)cc2)cn1 CHEMBL3797823 IC50 29.5 nM
Cn1cc(-c2ccc(-c3cncc4ccc(N5CCCC5=O)nc34)cc2)cn1 CHEMBL3827470 IC50 30.0 nM
Cn1ncc2ccc(N3CCN(c4cncc5ccccc45)CC3)cc21 CHEMBL4456001 Kd 30.0 nM
CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1 CHEMBL1336 IC50 30.0 nM
Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)NCCCN2CCN(C(=O)Nc3cc(C(C)(C)C)nn3-c3ccc(C)cc3)CC2)cc1 CHEMBL5270079 Kd 30.0 nM
CC1CCCN(c2ccnc3sc(C(N)=O)c(N)c23)C1 CHEMBL5076378 IC50 31.0 nM
NC(=O)c1sc2nccc(N3CCCN(c4ccccc4)CC3)c2c1N CHEMBL2348339 IC50 31.0 nM
Cc1ccccc1-c1c(-c2ccc3[nH]nc(N)c3c2)nnn1Cc1ccccc1 CHEMBL2000029 pKi 31.62 nM
CC(C)(C)Nc1ncnc2[nH]cc(-c3ccccc3)c12 CHEMBL1995211 pKi 31.62 nM
NC(=O)c1cc(-c2ccnc(N)n2)[nH]c1-c1ccc(Cl)cc1F CHEMBL1981079 pKi 31.62 nM
COc1cc(OC)cc(C(=O)Nc2n[nH]c3ccc(-c4cn(Cc5ccccc5)nn4)cc23)c1 CHEMBL2002613 pKi 31.62 nM
CC(=O)c1ccc2cncc(N3CCN(c4ccc5cnn(C)c5c4)CC3)c2c1 CHEMBL4584784 Kd 32.0 nM
Cn1cc(-c2ccc(-c3cncc(C(F)(F)F)c3N3CCC4(CC3)CNC(=O)O4)cc2)cn1 CHEMBL3799826 IC50 32.8 nM
CCCOCC1CCCN(c2ccnc3c2C(N)=C(C(N)=O)C3)C1 CHEMBL5090279 IC50 33.0 nM
CCOCCOC[C@H]1CCCN(c2ccnc3sc(C(N)=O)c(N)c23)C1 CHEMBL5071605 IC50 33.0 nM
CC(=O)Nc1ccc2cncc(-c3ccc(-c4cnn(C)c4)cc3)c2c1 CHEMBL3827699 IC50 34.0 nM
CC(=O)N(C)[C@H]1CC[C@@]2(C)[C@@H](CC[C@@H]3[C@@H]2CC[C@]2(C)[C@@H](c4ccc5ccncc5c4)CC[C@@H]32)C1 CHEMBL4170978 IC50 34.0 nM
COC[C@H]1CCCN(c2ccnc3sc(C(N)=O)c(N)c23)C1 CHEMBL5083027 IC50 34.0 nM
c1ccc(-c2cnc3[nH]ccc3c2)cc1 CHEMBL4091294 IC50 35.2 nM
Cn1cc(-c2ccc(-c3cnc(N)c4ccc(C(=O)N5CCCC5)nc34)cc2)cn1 CHEMBL3828266 IC50 35.5 nM
CN1CCCC12CCN(c1c(Cl)cncc1-c1ccc3c(c1)CS(=O)(=O)N3C)CC2 CHEMBL3798587 IC50 37.4 nM
O=C(CCCC[C@@H]1SC[C@H]2NC(=O)N[C@@H]12)NCC1CCN(CC(=O)Nc2ccc(Oc3ccc(NC(=O)Nc4cccc(C(F)(F)F)c4)cc3)cn2)CC1 CHEMBL5177635 IC50 38.5 nM
Cc1n[nH]c2ccc(-c3cncc(OCCN)c3)cc12 CHEMBL1967887 pKi 39.81 nM
CNCC#Cc1cnc(N)c2c(-c3ccc(NC(=O)Nc4cccc(C)c4)cc3)csc12 CHEMBL1964441 pKi 39.81 nM
Cc1ccc(NC(=O)CCc2cccc(-c3cnc4[nH]cc(Br)c4c3)c2)cc1C(F)(F)F CHEMBL5188580 IC50 40.3 nM
Nc1ccc(Oc2ccc(NC(=O)Nc3cccc(Cl)c3)cc2)cn1 CHEMBL5183125 IC50 40.6 nM
CN(C)[C@@H]1CC[C@@]2(C)[C@@H](CC[C@@H]3[C@@H]2CC[C@]2(C)C(c4cccnc4)=CC[C@@H]32)C1 CHEMBL4633633 Kd 41.0 nM
Cn1cc(-c2ccc(Cc3n[nH]c4ccc(C(=O)N5CC[C@@H](O)C5)cc34)cc2)cn1 CHEMBL3775317 IC50 42.0 nM
CC(=O)N1CCC(n2cc(Nc3ncc(Cl)c(-c4cnc5ccccn45)n3)cn2)CC1 CHEMBL3823659 IC50 42.0 nM
Cn1ncc2cc(Cc3n[nH]c4ccc(C(=O)N5CC[C@H](O)C5)cc34)ccc21 CHEMBL3775024 IC50 43.0 nM
Cn1cc(-c2ccc(-c3cncc4ccc(S(N)(=O)=O)cc34)cc2)cn1 CHEMBL3827333 IC50 43.0 nM
Cn1cc(-c2ccc(-c3cncc4ccc(-c5ncco5)nc34)cc2)cn1 CHEMBL3827150 IC50 45.0 nM
CN(C)[C@@H]1CC[C@@]2(C)[C@@H](CC[C@@H]3[C@@H]2CC[C@]2(C)C(c4ccc5cnccc5c4)=CC[C@@H]32)C1 CHEMBL4646453 Kd 45.0 nM
Cn1ncc2cc(-c3cnc4[nH]ccc4c3N3CCC4(CCNC4=O)CC3)ccc21 CHEMBL4856360 IC50 46.0 nM
Nc1ccc(Oc2ccc(NC(=O)Nc3cccc(C(F)(F)F)c3)cc2)cn1 CHEMBL5190752 IC50 46.5 nM
CN(C)c1nn(C)c2cc(-c3cncc(Cl)c3N3CCC4(CCNC4=O)CC3)ccc12 CHEMBL3798283 IC50 47.0 nM
Nc1ccc(Oc2ccc(NC(=O)Nc3cccc(F)c3)cc2)cn1 CHEMBL5187701 IC50 47.3 nM
C[C@]12CC[C@H]3[C@@H](CC=C4C[C@@H](O)CC[C@@]43C)[C@@H]1CC[C@@H]2c1ccc2ccncc2c1 CHEMBL4173827 IC50 48.0 nM
COCCN1CCCC12CCN(c1c(Cl)cncc1-c1ccc3c(c1)CS(=O)(=O)N3C)CC2 CHEMBL3798778 IC50 49.2 nM
Nc1ccc(Oc2cccc(NC(=O)Nc3ccc(F)c(C(F)(F)F)c3)c2)cn1 CHEMBL5174364 IC50 49.6 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(CC(C)O)c5)cnc(N)c34)cc2)c1 CHEMBL1989708 pKi 50.12 nM
CC(C)(CN)CNc1cc(-c2c[nH]c3ncccc23)cc(F)n1 CHEMBL1987261 pKi 50.12 nM
Clc1cc(-c2c[nH]c3ncccc23)ncn1 CHEMBL1972988 pKi 50.12 nM
Nc1n[nH]c2c(OCCCn3cccc3)ccc(-c3ccc(NC(=O)Nc4cccc(Cl)c4)cc3)c12 CHEMBL1965387 pKi 50.12 nM
Cc1cc(=O)n2ccc(CN(C)C)c(O)c2n1 CHEMBL1988581 pKi 50.12 nM
O=C(Nc1ccc(Oc2cnc3[nH]ccc3c2)cc1)Nc1cccc(C(F)(F)F)c1 CHEMBL5193587 IC50 50.4 nM
Nc1ccc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)cn1 CHEMBL5209455 IC50 51.1 nM
NC(=O)c1cccc(-c2cnc3[nH]ccc3c2)c1 CHEMBL5421134 IC50 51.9 nM
Cn1cc(-c2ccc(Cc3n[nH]c4ccc(C(=O)N5CC[C@H](O)C5)cc34)cc2)cn1 CHEMBL3775321 IC50 53.0 nM
Cc1ccc(NC(=O)/C=C/c2cccc(-c3cnc4[nH]ccc4c3)c2)cc1C(F)(F)F CHEMBL5199633 IC50 53.9 nM
CC(C)n1ncc2cc(-c3cnc(N)c(Cl)c3N3CCC4(CCNC4=O)CC3)ccc21 CHEMBL3800533 IC50 54.1 nM
CN1CCN(C(=O)c2ccc3cc(CCNc4ccnc5ccc(C#N)cc45)ccc3c2)CC1 CHEMBL4878072 Kd 55.0 nM
CN(C)C(=O)Cc1ccc(N2CCCN(c3ccnc4sc(C(N)=O)c(N)c34)CC2)cc1 CHEMBL2348353 Kd 55.0 nM
Nc1ccc(Oc2ccc(NC(=O)Nc3cccc(Br)c3)cc2)cn1 CHEMBL5185743 IC50 55.0 nM
Cc1ccc(NC(=O)Cc2cccc(-c3cnc4[nH]ccc4c3)c2)cc1C(F)(F)F CHEMBL5193550 IC50 55.1 nM
Cn1ncc2cc(Cc3n[nH]c4ccc(C(=O)N5CCC(F)(F)C5)cc34)ccc21 CHEMBL3775076 IC50 56.0 nM
Nc1cc(N2C(=O)c3cccnc3Oc3cc(NC(=O)Nc4ccc(Cl)c(C(F)(F)F)c4)ccc32)ccn1 CHEMBL4777657 IC50 57.5 nM
Nc1ccc(Oc2cccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)c2)cn1 CHEMBL5171978 IC50 59.1 nM
COCC(=O)Nc1cccc(-c2cnc3[nH]ccc3c2)c1 CHEMBL5441138 IC50 59.7 nM
COc1cccc(NC(=O)Nc2ccc(Oc3ccc(N)nc3)cc2)c1 CHEMBL5176210 IC50 60.2 nM
c1ccc(-c2cnc3[nH]cc(-c4ccccc4)c3c2)cc1 CHEMBL3102859 IC50 60.3 nM
O=C(Nc1cccc(Oc2cnc3[nH]ccc3c2)c1)Nc1cccc(C(F)(F)F)c1 CHEMBL5173581 IC50 61.7 nM
Nc1ccc(Oc2cccc(NC(=O)Nc3cccc(C(F)(F)F)c3)c2)cn1 CHEMBL5172387 IC50 62.3 nM
OCc1cccc(-c2cnc3[nH]ccc3c2)c1 CHEMBL5406308 IC50 62.4 nM
O=C(CCc1cccc(-c2cnc3[nH]ccc3c2)c1)Nc1cc(F)cc(F)c1 CHEMBL5186605 IC50 62.8 nM
C#Cc1cn(C2CCCC2)c2ncnc(N)c12 CHEMBL1993877 pKi 63.1 nM
CCc1ccc2nccc(NC(=O)Nc3cccc(C(F)(F)F)n3)c2c1 CHEMBL2000934 pKi 63.1 nM
COc1ccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(CC(O)CO)c5)cnc(N)c34)cc2)cc1 CHEMBL1965170 pKi 63.1 nM
O=C(Nc1cccc(C(F)(F)F)n1)Nc1ccnc2ccc(Cl)cc12 CHEMBL1967513 pKi 63.1 nM
O=C(Nc1cccc(F)c1)Nc1cccc(-c2ccc3cn[nH]c3c2)c1 CHEMBL1983393 pKi 63.1 nM
O=C(Nc1cc(-c2c[nH]c3ncccc23)cc(Cl)n1)c1c(F)cccc1F CHEMBL1991410 pKi 63.1 nM
CN(C)[C@@H]1CC[C@@]2(C)[C@@H](CC[C@@H]3[C@@H]2CC[C@]2(C)[C@@H](c4ccc5ccncc5c4)CC[C@@H]32)C1 CHEMBL4159279 IC50 64.0 nM
O=C(CCc1cccc(-c2cnc3[nH]ccc3c2)c1)Nc1ccc(NCCN2CCOCC2)c(C(F)(F)F)c1 CHEMBL5203621 IC50 64.5 nM
Cn1cc(-c2ccc(-c3cncc4ccc(C(=O)N5CCNCC5)nc34)cc2)cn1 CHEMBL3827673 IC50 65.0 nM
NC(=O)c1sc(Oc2ccccn2)c2c1CCc1cnsc1-2 CHEMBL4061783 EC50 66.0 nM
Nc1ccc(Oc2cccc(NC(=O)Nc3ccc(F)cc3)c2)cn1 CHEMBL5170240 IC50 68.4 nM
Cc1ccc(NC(=O)CCc2cccc(-c3cnc4[nH]cc(Cl)c4c3)c2)cc1C(F)(F)F CHEMBL5187110 IC50 68.5 nM
Cn1cc(-c2ccc(-c3cnc(N)c4ccc(C(=O)N5CCC5)cc34)cc2)cn1 CHEMBL3828470 IC50 70.0 nM
Cc1ncc2sc(C(=O)N3CCC[C@H]3c3ccc(Cl)cc3)nn12 CHEMBL3938208 IC50 70.0 nM
C[S+]([O-])c1sc(C(N)=O)c2c1-c1sncc1CC2 CHEMBL4102907 EC50 70.0 nM
O=C(NCCc1cccc(-c2cnc3[nH]ccc3c2)c1)c1ccc(Cl)c(C(F)(F)F)c1 CHEMBL5169620 IC50 70.4 nM
Cn1cc(-c2ccc(-c3cnc(N)c4ccc(C(=O)N5CCOCC5)nc34)cc2)cn1 CHEMBL3827675 IC50 73.0 nM
CNC(=O)c1ccc2[nH]nc(Cc3ccc(-c4cnn(CC(C)(C)O)c4)cc3)c2c1 CHEMBL3775775 IC50 76.0 nM
CC(=O)Nc1ccc2c(N)ncc(-c3ccc(-c4cnn(C)c4)cc3)c2c1 CHEMBL3828310 IC50 76.0 nM
CN(C)C(=O)c1ccc(N2CCCN(c3ccnc4sc(C(N)=O)c(N)c34)CC2)cc1 CHEMBL2348350 Kd 78.0 nM
Cn1cc(-c2ccc(-c3cncc(F)c3N3CCC4(CCNC4=O)CC3)cc2)cn1 CHEMBL3798362 IC50 79.3 nM
O=C(Nc1cc(-c2c[nH]c3ncccc23)cc(Cl)n1)c1ccccc1 CHEMBL1993413 pKi 79.43 nM
CCN(CC)CCCNC(=O)c1cnc(N)c2c(-c3ccc(NC(=O)Nc4cccc(C)c4)cc3)csc12 CHEMBL1999414 pKi 79.43 nM
N#Cc1ccc(-c2ccncc2)cc1NCc1ccccc1 CHEMBL1967992 pKi 79.43 nM
O=C(Nc1cccc(C(F)(F)F)n1)Nc1ccnc2ccc(F)cc12 CHEMBL2007603 pKi 79.43 nM
O=C(NCCc1cccs1)N1CC=C(c2c[nH]c3ncccc23)CC1 CHEMBL1987535 pKi 79.43 nM
Cn1cc(-c2ccc(Cc3n[nH]c4ccc(N5CCCC5=O)cc34)cc2)cn1 CHEMBL3775547 IC50 82.0 nM
CN(C)C(=O)Cc1ccc(N2CCCN(c3ccnc4ccc(C#N)cc34)CC2)cc1 CHEMBL4853053 IC50 82.0 nM
Cn1cc(-c2ccncc2/C=C/C(=O)Nc2ccc(CN3CC(F)(F)C3)cc2)cn1 CHEMBL4087859 EC50 84.0 nM
c1ccc(-c2cnc3[nH]cc(-c4ccoc4)c3c2)cc1 CHEMBL5434520 IC50 85.1 nM
Cc1ccc(NC(=O)CCc2cc(-c3cnc4[nH]ccc4c3)ccc2Cl)cc1C(F)(F)F CHEMBL5200463 IC50 85.4 nM
Cn1cc(-c2ccc(-c3cncc4ccc(N5CCCS5(=O)=O)cc34)cc2)cn1 CHEMBL3827790 IC50 87.0 nM
Cn1cc(-c2ccc(-c3cnc(N)c4ccc(-c5nccn5C)nc34)cc2)cn1 CHEMBL3828129 IC50 87.0 nM
Cc1ncc2ccc(C(=O)N3CCC[C@H]3c3ccc(Cl)cc3)cn12 CHEMBL3948055 IC50 90.0 nM
CC(C)c1cnn2c(NCc3ccccc3)cc(N[C@@H](CO)[C@H](O)CO)nc12 CHEMBL1234833 IC50 90.0 nM
O=C(Nc1ccc(Oc2cnc3[nH]ccc3c2)cc1)Nc1ccc(Cl)c(C(F)(F)F)c1 CHEMBL5191407 IC50 90.9 nM
NC(=O)c1sc2nccc(N3CCCC(CO)C3)c2c1N CHEMBL5078832 IC50 93.0 nM
Cn1cc(-c2ccc(Cc3n[nH]c4ccc(C(=O)N5CC(O)C5)cc34)cc2)cn1 CHEMBL3775423 IC50 94.0 nM
Nc1ccc(Oc2cccc(NC(=O)Nc3ccc(F)c(Cl)c3)c2)cn1 CHEMBL5173845 IC50 94.6 nM
Cn1cc(-c2ccncc2CCC(=O)Nc2ccc(CN3CCOCC3)cc2)cn1 CHEMBL4074871 EC50 95.0 nM
COc1ccc(-c2ccncc2/C=C/C(=O)Nc2ccc(CN3CCOCC3)cc2)s1 CHEMBL4097361 EC50 97.0 nM
CCCCNC(=O)Nc1cccc(-c2cnc3[nH]ccc3c2)c1 CHEMBL5440418 IC50 98.4 nM
CS(=O)(=O)NC1CCC(Nc2cc(Cl)nc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL2005216 pKi 100.0 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(C#CCCCCCCCCN)cnc(N)c34)cc2)c1 CHEMBL1978166 pKi 100.0 nM
O=C(Nc1cccc(C(F)(F)F)n1)Nc1ccnc2cc(F)c(F)cc12 CHEMBL1981792 pKi 100.0 nM
O=C(Nc1cnccn1)Nc1ccnc2ccc(N3CC4COCC4C3)cc12 CHEMBL2002599 pKi 100.0 nM
Cn1cc(-c2ccc(Cc3n[nH]c4ccc(C(=O)NC5CC5)cc34)cc2)cn1 CHEMBL3775680 IC50 100.0 nM
Cc1ncc2sc(C(=O)N3CCCC3c3ccc(Cl)cc3)nn12 CHEMBL3934243 IC50 100.0 nM
O=C(c1ccc2[nH]ncc2c1)N1CCC[C@H]1c1ccc(Cl)cc1 CHEMBL3929167 IC50 100.0 nM
C[C@]12CC[C@H](O)CC1=CC[C@@H]1[C@@H]2CC[C@]2(C)C(c3ccc4ccncc4c3)=CC[C@@H]12 CHEMBL4164953 IC50 101.0 nM
C[C@]12CC[C@H]3[C@@H](CC=C4C[C@@H](O)CC[C@@]43C)[C@@H]1CC[C@@H]2c1ccc2nc(N)ncc2c1 CHEMBL4172737 IC50 101.0 nM
CN(C)[C@H]1CC[C@@]2(C)[C@@H](CC[C@@H]3[C@@H]2CC[C@]2(C)C(c4ccc5ccncc5c4)=CC[C@@H]32)C1 CHEMBL4793909 IC50 101.0 nM
CN(C)[C@H]1CC[C@@]2(C)C(=CC[C@@H]3[C@@H]2CC[C@]2(C)C(c4ccc5ccncc5c4)=CC[C@@H]32)C1 CHEMBL4799612 IC50 101.0 nM
C[C@]12CC[C@H](N3CCOCC3)C[C@@H]1CC[C@@H]1[C@@H]2CC[C@]2(C)[C@@H](c3ccc4ccncc4c3)CC[C@@H]12 CHEMBL4160370 IC50 101.0 nM
CN(C)C(=O)c1ccc2cc(CCNc3ccnc4ccc(C#N)cc34)ccc2c1 CHEMBL4856755 IC50 103.0 nM
NCc1cccc(-c2cnc3[nH]ccc3c2)c1 CHEMBL5399338 IC50 106.6 nM
CC(=O)Nc1ccc2[nH]nc(Cc3ccc(-c4cnn(C)c4)cc3)c2c1 CHEMBL3775496 IC50 110.0 nM
O=C(/C=C/c1cnccc1-c1cnsc1)Nc1ccc(CN2CCOCC2)cc1 CHEMBL4094902 EC50 110.0 nM
Cn1cc(-c2ccncc2/C=C/C(=O)Nc2ccccc2)cn1 CHEMBL4083599 EC50 110.0 nM
Cc1n[nH]c2ccc(C(=O)N3CCOCC3c3ccc(Cl)cc3)cc12 CHEMBL3938357 IC50 115.0 nM
O=Cc1cccc(-c2cnc3[nH]ccc3c2)c1 CHEMBL5415489 IC50 116.2 nM
N#Cc1ccc2nccc(NCCc3ccc4cc(C(=O)N5CCN(CCCO)CC5)ccc4c3)c2c1 CHEMBL4868007 IC50 117.0 nM
Cc1ccc(NC(=O)Nc2cccc(Oc3ccc(N)nc3)c2)cc1Cl CHEMBL5177671 IC50 117.5 nM
CN1CC[C@H](c2c(O)cc(O)c3c(=O)cc(-c4ccccc4Cl)oc23)[C@H](O)C1 CHEMBL428690 Kd 120.0 nM
Nc1n[nH]c2ccc(C(=O)N3CCC[C@H]3c3ccc(F)cc3)cc12 CHEMBL3975326 IC50 120.0 nM
Cc1n[nH]c2cnc(C(=O)N3CCC[C@H]3c3ccc(Cl)cc3)cc12 CHEMBL3916750 IC50 125.0 nM
O=C(Nc1cnccn1)Nc1ccnc2ccccc12 CHEMBL1981720 pKi 125.89 nM
NC(=O)c1ccc2nc(-c3ccc([N+](=O)[O-])o3)cn2c1 CHEMBL1973359 pKi 125.89 nM
O=C(Nc1ccc(-c2ccc3cn[nH]c3c2)cc1)Nc1cccc(F)c1 CHEMBL1969942 pKi 125.89 nM
N#Cc1ccc(NC(=O)CCc2cccc(-c3cnc4[nH]ccc4c3)c2)cc1C(F)(F)F CHEMBL5199011 IC50 125.9 nM
Nc1ccc(Oc2ccc(NC(=O)Nc3ccc(F)c(C(F)(F)F)c3)cc2)cn1 CHEMBL5174994 IC50 128.6 nM
COc1cc2c(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3F)ccnc2cc1OCCCN1CCOCC1 CHEMBL1230609 Kd 130.0 nM
O=C(CCc1cnccc1-c1cnn(C2CC2)c1)Nc1ccc(CN2CCOCC2)cc1 CHEMBL4093832 EC50 130.0 nM
NC(=O)c1sc2nccc(N3CCCCC3)c2c1N CHEMBL2348334 IC50 130.0 nM
CC(=O)Nc1ccc(Oc2ccc(NC(=O)Nc3cccc(C(F)(F)F)c3)cc2)cn1 CHEMBL5198994 IC50 130.9 nM
O=C(CO)Nc1cccc(-c2cnc3[nH]ccc3c2)c1 CHEMBL5431726 IC50 136.3 nM
Cn1cc(-c2ccc(Cc3n[nH]c4ccc(C(=O)N5CCNCC5)cc34)cc2)cn1 CHEMBL3775562 IC50 140.0 nM
O=C(/C=C/c1cnccc1-c1cncs1)Nc1ccc(CN2CCOCC2)cc1 CHEMBL4105077 EC50 140.0 nM
CNC(=O)c1sc(SC)c2c1CCc1cnsc1-2 CHEMBL4062262 EC50 140.0 nM
COCCCN1CCCC12CCN(c1c(Cl)cncc1-c1ccc3c(c1)CS(=O)(=O)N3C)CC2 CHEMBL3800399 IC50 141.0 nM
CC(=O)OCC(=O)Nc1cccc(-c2cnc3[nH]ccc3c2)c1 CHEMBL5403765 IC50 142.5 nM
O=C(CCc1cccc(-c2cnc3[nH]ccc3c2)c1)Nc1cccc(F)c1F CHEMBL5187943 IC50 143.3 nM
Cc1cccc(NC(=O)Nc2ccc(Oc3ccc(N)nc3)cc2)c1 CHEMBL5177423 IC50 145.2 nM
CN1c2ccc(-c3cncc(Cl)c3N3CCC4(CCCN4CCCS(C)(=O)=O)CC3)cc2CS1(=O)=O CHEMBL3799159 IC50 146.0 nM
Nc1n[nH]c2ccc(C(=O)N3CC[C@@H](c4ccc(Cl)cc4)C3)cc12 CHEMBL3955876 IC50 150.0 nM
O=C(/C=C/c1cnccc1-c1cnn(CC(F)(F)F)c1)Nc1ccc(CN2CCOCC2)cc1 CHEMBL4085116 EC50 150.0 nM
OCCc1cccc(-c2cnc3[nH]ccc3c2)c1 CHEMBL5409187 IC50 151.9 nM
Nc1ccc(Oc2cccc(NC(=O)Nc3ccc(Cl)c(Cl)c3)c2)cn1 CHEMBL5203799 IC50 155.7 nM
Nc1ccc(Oc2ccc(NC(=O)Nc3cccc(Cl)c3Cl)cc2)cn1 CHEMBL5202901 IC50 155.8 nM
Cc1ccc(NC(=O)CCc2cccc(-c3cnc4[nH]ccc4c3)c2)cc1F CHEMBL5179085 IC50 158.4 nM
O=C(Nc1ccc(-c2ccc(=O)[nH]n2)cc1)Nc1cccc(C(F)(F)F)c1 CHEMBL2007124 pKi 158.49 nM
Cc1cc(=O)[nH]nc1-c1ccc(NC(=O)Nc2cc(C(F)(F)F)ccc2F)c(Cl)c1 CHEMBL1997892 pKi 158.49 nM
N#Cc1ccc2nc(N)n(-c3nccs3)c2c1 CHEMBL1988805 pKi 158.49 nM
CCCC(=O)Nc1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12 CHEMBL1977223 pKi 158.49 nM
Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(OCCN3CCOCC3)c3ccccc23)cc1 CHEMBL103667 pKi 158.49 nM
Nc1ncc(-c2cnn(CCO)c2)c2scc(-c3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12 CHEMBL1980297 pKi 158.49 nM
CN(C(=O)CCOCCOCCOCCOCCNc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O)[C@H]1CC[C@@]2(C)[C@@H](CC[C@@H]3[C@@H]2CC[C@]2(C)[C@@H](c4ccc5ccncc5c4)CC[C@@H]32)C1 CHEMBL4176300 IC50 159.0 nM
Cn1ncc2cc(Cc3n[nH]c4ccc(C(=O)N5CC(O)C5)cc34)ccc21 CHEMBL3775123 IC50 160.0 nM
c1ccc(-c2cnc3[nH]cc(-c4ccsc4)c3c2)cc1 CHEMBL5399686 IC50 162.1 nM
Cc1ccc(NC(=O)CCc2cccc(-c3cnc4[nH]cc(I)c4c3)c2)cc1C(F)(F)F CHEMBL5205472 IC50 167.5 nM
Cc1ccc(NC(=O)CNc2cccc(-c3cnc4[nH]ccc4c3)c2)cc1C(F)(F)F CHEMBL5192875 IC50 169.8 nM
O=C(CCc1cccc(-c2cnc3[nH]ccc3c2)c1)Nc1ccc(Cl)c(C(F)(F)F)c1 CHEMBL5169918 IC50 177.2 nM
Cc1ccc(NC(=O)COc2cccc(-c3cnc4[nH]ccc4c3)c2)cc1C(F)(F)F CHEMBL5177966 IC50 185.2 nM
Cc1ccc(NC(=O)/C=C/c2cc(-c3cnc4[nH]ccc4c3)ccc2Cl)cc1C(F)(F)F CHEMBL5200780 IC50 185.4 nM
Cc1ccc(NC(=O)CCc2cccc(-c3cnc4[nH]ccc4c3)c2)cc1 CHEMBL5170909 IC50 187.6 nM
COc1ccc(NC(=O)CCc2cccc(-c3cnc4[nH]ccc4c3)c2)cc1 CHEMBL5175694 IC50 190.7 nM
CN(C(=O)CCOCCOCCNc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O)[C@H]1CC[C@@]2(C)[C@@H](CC[C@@H]3[C@@H]2CC[C@]2(C)[C@@H](c4ccc5ccncc5c4)CC[C@@H]32)C1 CHEMBL4170540 IC50 192.0 nM
Nc1ccc(Oc2cccc(NC(=O)Nc3cccc(Cl)c3)c2)cn1 CHEMBL5178424 IC50 192.3 nM
CN(C)C/C=C/C(=O)Nc1cccc(C(=O)Nc2cccc(Nc3ncc(Cl)c(-c4c[nH]c5ccccc45)n3)c2)c1 CHEMBL4303287 IC50 194.0 nM
CN1CCN(C(=O)c2ccc3nc(CCNc4ccnc5ccc(C#N)cc45)ccc3c2)CC1 CHEMBL4875076 IC50 195.0 nM
Cc1ccc(NC(=O)/C=C/c2cc(-c3cnc4[nH]ccc4c3)ccc2F)cc1C(F)(F)F CHEMBL5202198 IC50 197.2 nM
NC(=O)c1ccc(-c2c[nH]c3nccc(Cl)c23)cc1 CHEMBL1982711 pKi 199.53 nM
Cc1cc(=O)[nH]nc1-c1ccc(NC(=O)Nc2cc(C(F)(F)F)ccc2F)cc1 CHEMBL1965033 pKi 199.53 nM
CC(C)(C)c1cnc(CSc2cnc(NC(=O)C3CCNCC3)s2)o1 CHEMBL296468 pKi 199.53 nM
CCc1c(-c2ccc(C(C)=O)cc2)[nH]c2nccnc12 CHEMBL1994555 pKi 199.53 nM
Cc1c[nH]c2nccc(Oc3c(F)cc(Nc4cc(Cl)nc(N)n4)cc3F)c12 CHEMBL1971943 pKi 199.53 nM
COc1ccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(CC(C)(C)O)c5)cnc(N)c34)cc2)cc1 CHEMBL2004290 pKi 199.53 nM
Cc1ccc2nccc(NC(=O)Nc3cccc(C(F)(F)F)n3)c2c1 CHEMBL1964444 pKi 199.53 nM
Cn1cnc(-c2ccc3[nH]nc(Cc4ccc(-c5cnn(C)c5)cc4)c3c2)c1 CHEMBL3775519 IC50 200.0 nM
CSc1sc(C(N)=O)c2c1-c1oncc1CC2 CHEMBL4069269 EC50 200.0 nM
C[C@]12CC[C@H](O)C[C@@H]1CC[C@@H]1[C@@H]2CC[C@]2(C)[C@@H](c3ccc4ccncc4c3)CC[C@@H]12 CHEMBL4169344 IC50 201.0 nM
CN(C)C(=O)c1ccc(N2CCCN(c3ccnc4ccc(C#N)cc34)CC2)cc1 CHEMBL4858759 IC50 203.0 nM
Cc1ccc(NC(=O)Nc2cccc(Oc3ccc(N)nc3)c2)cc1 CHEMBL5172664 IC50 205.3 nM
CCNC(=O)Nc1cccc(-c2cnc3[nH]ccc3c2)c1 CHEMBL5409281 IC50 212.8 nM
CC(=O)c1cccc(-c2cnc3[nH]ccc3c2)c1 CHEMBL2000568 IC50 215.6 nM
N#Cc1ccc2nccc(NCCc3ccccc3)c2c1 CHEMBL4855789 IC50 217.0 nM
Nc1ccc(Oc2cccc(NC(=O)Nc3cccc(Br)c3)c2)cn1 CHEMBL5175237 IC50 219.5 nM
CS(=O)(=O)c1sc(C(N)=O)c2c1-c1sncc1CC2 CHEMBL4097047 EC50 220.0 nM
NS(=O)(=O)c1cccc(-c2cnc3[nH]ccc3c2)c1 CHEMBL5412040 IC50 220.6 nM
CCNC(=O)c1cccc(-c2cnc3[nH]ccc3c2)c1 CHEMBL5426252 IC50 224.8 nM
Cc1ccc(NC(=O)CSc2cccc(-c3cnc4[nH]ccc4c3)c2)cc1C(F)(F)F CHEMBL5207793 IC50 225.3 nM
Cc1n[nH]c2ccc(C(=O)N3CCN(C)CC3c3ccc(Cl)cc3)cc12 CHEMBL3967915 IC50 230.0 nM
CC(O)c1cccc(-c2cnc3[nH]ccc3c2)c1 CHEMBL5412342 IC50 230.4 nM
CC(C)(C)c1cc(NC(=O)Nc2cccc3ccccc23)n(-c2cccc(C(=O)NCCOCCO)c2)n1 CHEMBL1978271 pKi 251.19 nM
Oc1cc(O)cc(C=Cc2ccc(O)c(O)c2)c1 CHEMBL1972346 pKi 251.19 nM
CCNc1nc(C)c(-c2ccnc(Nc3ccc(N4CCN(C(C)=O)CC4)cc3)n2)s1 CHEMBL1983715 pKi 251.19 nM
O=C(Nc1cnccn1)Nc1ccnc2c(F)cc(F)cc12 CHEMBL1967336 pKi 251.19 nM
Nc1ncnc2c1c(-c1ccc(Oc3ccc(CO)cc3)cc1)cn2C1CCOC1 CHEMBL1976376 pKi 251.19 nM
CCC(=O)Nc1ccc(C(=O)N2CCNCC2)c(O)c1 CHEMBL1988141 pKi 251.19 nM
COc1ccc2[nH]cc(C=C3C(=O)Nc4ccccc43)c2c1 CHEMBL1997275 pKi 251.19 nM
c1ccc(-c2cnc3[nH]cc(-c4cccs4)c3c2)cc1 CHEMBL5397227 IC50 264.8 nM
Cn1cc(-c2ccc(Cc3n[nH]c4ccc(C(N)=O)cc34)cc2)cn1 CHEMBL3775614 IC50 270.0 nM
Cc1cccc(NC(=O)Nc2cccc(Oc3ccc(N)nc3)c2)c1 CHEMBL5183427 IC50 271.8 nM
CNC(=O)c1cccc(-c2cnc3[nH]ccc3c2)c1 CHEMBL5083764 IC50 276.0 nM
Cc1ncc2sc(C(=O)N3CCCC3c3ccc(F)cc3)nn12 CHEMBL3906261 IC50 290.0 nM
C[C@]12CC[C@H]3[C@@H](CC=C4C[C@@H](O)CC[C@@]43C)[C@@H]1CC[C@@H]2c1ccc2c(N)n[nH]c2c1 CHEMBL4175290 IC50 301.0 nM
Cn1cc(-c2ccc(Cc3n[nH]c4ccc(S(=O)(=O)NC5CC5)cc34)cc2)cn1 CHEMBL3774509 IC50 313.0 nM
O=C(O)c1ccccc1Nc1ccnc(Nc2ccc3cn[nH]c3c2)n1 CHEMBL244378 pKi 316.23 nM
COc1c(-c2nc3ccccc3[nH]2)c(O)cc2oc(C)cc(=O)c12 CHEMBL1972355 pKi 316.23 nM
CC(C)(C)c1cc(NC(=O)C(=O)c2cccc3ccccc23)n(-c2cccc(OCC(=O)O)c2)n1 CHEMBL1964902 pKi 316.23 nM
Oc1cnc2ccc(-c3ccncc3)cc2c1 CHEMBL1973868 pKi 316.23 nM
O=C(O)c1ccccc1Nc1ccnc(Nc2ccc([N+](=O)[O-])cc2)n1 CHEMBL242865 pKi 316.23 nM
NC(COc1cncc(-c2ccc3cnccc3c2)c1)Cc1c[nH]c2ccccc12 CHEMBL1981133 pKi 316.23 nM
O=C(Nc1cnccn1)Nc1cccc2c(O)cccc12 CHEMBL1992371 pKi 316.23 nM
Cc1ccc(NCc2ccc(-c3ccc(F)cc3)nc2)cc1 CHEMBL1986899 pKi 316.23 nM
Nc1ccc(Oc2cccc(NC(=O)Nc3ccccc3F)c2)cn1 CHEMBL5169532 IC50 317.2 nM
O=C(NCc1ccccc1F)Nc1ccc2c(c1)Oc1ncccc1C(=O)N2c1ccncc1 CHEMBL4800453 IC50 324.0 nM
c1cc2cc(c1)-c1cnc3ccc(nn13)NCCCCCO2 CHEMBL4104223 EC50 337.0 nM
O=[N+]([O-])c1ccc2nccc(NCCc3ccccc3)c2c1 CHEMBL4863646 IC50 346.0 nM
Cc1ccc(NC(=O)Nc2ccc(Oc3cnc4[nH]ccc4c3)cc2)cc1C(F)(F)F CHEMBL5197639 IC50 355.6 nM
CNC(=O)c1cc(N2C(=O)c3cccnc3Oc3cc(NC(=O)Nc4ccc(Cl)c(C(F)(F)F)c4)ccc32)ccn1 CHEMBL4780260 IC50 361.0 nM
Nc1ccc(Sc2ccc(NC(=O)Nc3cccc(C(F)(F)F)c3)cc2)cn1 CHEMBL5180478 IC50 387.4 nM
Cn1cc(-c2ccc(-c3cncc4ccc(C#N)nc34)cc2)cn1 CHEMBL3828169 IC50 396.0 nM
CN(C)CCCN(C)C(=O)c1cccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2cccc3ccccc23)c1 CHEMBL1964948 pKi 398.11 nM
Nc1ncnn2ccc(C(=O)Nc3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12 CHEMBL1990583 pKi 398.11 nM
N#CC1=C(c2ccccc2)CC(c2ccc(Cl)cc2)C(C(=O)c2ccccc2)C1=O CHEMBL1978371 pKi 398.11 nM
O=C(Cc1cccs1)Nc1nc2ccccc2s1 CHEMBL1421720 pKi 398.11 nM
CC(C)(C)c1cc(NC(=O)Nc2cccc3ccccc23)n(-c2cccc(C(=O)NCCCO)c2)n1 CHEMBL2007073 pKi 398.11 nM
COC[C@@H]1CCCN(c2ccnc3sc(C(N)=O)c(N)c23)C1 CHEMBL5088336 IC50 410.0 nM
Cc1ncc2sc(C(=O)N3CCCC3c3ccccc3)nn12 CHEMBL3899488 IC50 415.0 nM
Nc1n[nH]c2ccc(C(=O)N3CC[C@H]3c3ccc(F)cc3)cc12 CHEMBL3964636 IC50 435.0 nM
CN1C(=O)CCC(N2C(=O)c3cccc(NCCOCCOCCOCCOCCC(=O)N(C)[C@H]4CC[C@@]5(C)[C@@H](CC[C@@H]6[C@@H]5CC[C@]5(C)[C@@H](c7ccc8ccncc8c7)CC[C@@H]65)C4)c3C2=O)C1=O CHEMBL4164360 IC50 443.0 nM
N#Cc1ccc2nccc(NCCc3ccc4cc(C(=O)N5CCNCC5)ccc4c3)c2c1 CHEMBL4851694 IC50 449.0 nM
COC(=O)c1cccc(-c2cnc3[nH]ccc3c2)c1 CHEMBL5075969 IC50 455.7 nM
O=C(Nc1cccc(Oc2cnc3[nH]ccc3c2)c1)Nc1ccc(Cl)c(C(F)(F)F)c1 CHEMBL5195693 IC50 488.3 nM
CSc1sc(C#N)c2c1-c1sncc1CC2 CHEMBL4082699 EC50 490.0 nM
CC1CCc2nc(N)c(C#N)c(-c3cccnc3)c2C1 CHEMBL1409113 IC50 500.0 nM
O=C(O)c1ccccc1Nc1ccnc(Nc2cccc(F)c2)n1 CHEMBL243298 pKi 501.19 nM
OC1CCC(Nc2cc(Cl)nc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1991674 pKi 501.19 nM
COCOc1cccc(OCOC)c1-c1ccc(NS(C)(=O)=O)cc1C(=O)OC CHEMBL2004025 pKi 501.19 nM
CC(N)C1CCC(C(=O)Nc2ccnc3[nH]ccc23)CC1 CHEMBL2002992 pKi 501.19 nM
Nc1noc2cccc(-c3cccc(O)c3)c12 CHEMBL1970340 pKi 501.19 nM
CCN(CC)CCCNC(=O)c1cnc(N)c2c(-c3ccc(NC(=O)Nc4cccc(F)c4)cc3)csc12 CHEMBL1996649 pKi 501.19 nM
CC(C)(C)c1cc(NC(=O)C(=O)c2cccc3ccccc23)n(-c2ccc(OCC(=O)O)cc2)n1 CHEMBL2005699 pKi 501.19 nM
C=CCc1cccc2c(=NO)cc(-c3ccccc3)oc12 CHEMBL1977749 pKi 501.19 nM
CC(C)(C)c1cc(NC(=O)C(=O)c2cccc3ccccc23)n(-c2cccc(OCC(=O)NCCO)c2)n1 CHEMBL1998680 pKi 501.19 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL388978 Kd 510.0 nM
CC1CCN(c2ccnc3sc(C(N)=O)c(N)c23)CC1 CHEMBL5093576 IC50 520.0 nM
CSc1sc(C(N)=O)c2c1-c1snnc1CC2 CHEMBL4060582 EC50 550.0 nM
Cn1cc(-c2ccc(-c3cncc(Cl)c3N3CCC4(CC3)COC(=O)N4)cc2)cn1 CHEMBL3798712 IC50 555.0 nM
Cn1cc(-c2ccc(-c3cnc(N)c4ccc(C(=O)N5CCNCC5)nc34)cc2)cn1 CHEMBL3828472 IC50 559.0 nM
Cn1cc(-c2ccc(-c3cncc4ccc(C(=O)O)nc34)cc2)cn1 CHEMBL3827482 IC50 590.0 nM
O=C(Nc1ccccc1)Nc1ccc2c(c1)Oc1ncccc1C(=O)N2c1ccoc1 CHEMBL4796082 IC50 593.0 nM
Cc1nc(CC(=O)N2CCN(c3cncc4ccccc34)CC2)co1 CHEMBL4447689 Kd 600.0 nM
CSc1sc(C(=O)Nc2ccsn2)c2c1-c1sncc1CC2 CHEMBL4084957 EC50 620.0 nM
CC(C)(C)CCOc1cc(-c2ccc(C(N)=O)cc2)cc2[nH]nc(N)c12 CHEMBL2001398 pKi 630.96 nM
CC(C)(C)c1cc(NC(=O)Nc2cccc3ccccc23)n(-c2cccc(C(=O)NCCCCO)c2)n1 CHEMBL1994977 pKi 630.96 nM
CCOc1ccc(C=C2SC(=N)NC2=O)c(O)c1 CHEMBL1971289 pKi 630.96 nM
CC(C)(C)c1cc(NC(=O)C(=O)c2cccc3ccccc23)n(-c2ccc(OCCC(=O)O)cc2)n1 CHEMBL2003689 pKi 630.96 nM
COc1ccc(-c2cc(=O)c3c(O)cc(O)cc3o2)cc1 CHEMBL243664 pKi 630.96 nM
O=C(NN=Cc1cc(Br)c(O)c(Br)c1)Nc1ccccc1 CHEMBL1983575 pKi 630.96 nM
O=C(Nc1nc2ccccc2s1)c1cccc2c1CN(c1nc(C(=O)O)c(-c3ccc(CO)cc3)s1)CC2 CHEMBL1983980 pKi 630.96 nM
NC(=O)c1ccc(-c2ccncc2/C=C/C(=O)Nc2ccc(CN3CCOCC3)cc2)s1 CHEMBL4079336 EC50 690.0 nM
C[C@]12CC[C@H](O)C[C@@H]1CC[C@@H]1[C@@H]2CC[C@]2(C)C(c3ccc4ccncc4c3)=CC[C@@H]12 CHEMBL4176230 IC50 701.0 nM
C[C@]12CC[C@H](O)CC1=CC[C@@H]1[C@@H]2CC[C@]2(C)C(c3ccc4c(N)n[nH]c4c3)=CC[C@@H]12 CHEMBL4170388 IC50 701.0 nM
CN[C@H]1CC[C@@]2(C)[C@@H](CC[C@@H]3[C@@H]2CC[C@]2(C)[C@@H](c4ccc5ccncc5c4)CC[C@@H]32)C1 CHEMBL4163735 IC50 701.0 nM
COCCN1CCCC12CCN(c1c(Cl)cncc1-c1ccc(-c3cnn(C)c3)cc1)CC2 CHEMBL3797689 IC50 702.0 nM
Cn1cc(-c2ccc(Cc3n[nH]c4ccc(NS(C)(=O)=O)cc34)cc2)cn1 CHEMBL3774400 IC50 710.0 nM
CCn1c(C)c(-c2ccnc(Nc3cccc(OC)c3)n2)sc1=O CHEMBL1986263 pKi 794.33 nM
O=C(Nc1cccc(C2Nc3ccc4ccccc4c3C3C=CCC32)c1)c1ccc(F)cc1 CHEMBL1992042 pKi 794.33 nM
O=C1Cc2c([nH]c3ccc([N+](=O)[O-])cc23)-c2ccccc2N1 CHEMBL50894 pKi 794.33 nM
OC1CCCC(Nc2cc(Cl)nc(-c3c[nH]c4ncccc34)n2)C1 CHEMBL1976936 pKi 794.33 nM
NC(=O)c1cc2ccncc2s1 CHEMBL1971534 pKi 794.33 nM
CCN(CCN(C)C)C(=O)c1cccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2cccc3ccccc23)c1 CHEMBL1992354 pKi 794.33 nM
Cn1cc(Nc2ncc(Br)c(Nc3ccccc3C(N)=O)n2)cn1 CHEMBL1994669 pKi 794.33 nM
CN(C)c1ccc(-c2cc(-c3ccc([N+](=O)[O-])cc3)nc(NS(=O)(=O)c3ccc(N)cc3)n2)cc1 CHEMBL1980167 pKi 794.33 nM
CC(C)(C)n1nc(-c2ccc(Cl)cc2)c2c(N)ncnc21 CHEMBL406845 pKi 794.33 nM
Nc1n[nH]c2ccc(C(=O)N3CCCC[C@H]3c3ccc(F)cc3)cc12 CHEMBL3984494 IC50 800.0 nM
Cc1nn(C2CCN(C(=O)[C@@H](C)O)CC2)c(C)c1Nc1ncc(Cl)c(-c2cnn3ccccc23)n1 CHEMBL3823030 IC50 810.0 nM
N#Cc1ccc2ncnc(NCCc3ccccc3)c2c1 CHEMBL4226806 Kd 830.0 nM
O=C(Nc1ccc(Oc2cnc3[nH]ccc3c2)cc1)Nc1cccc(Cl)c1 CHEMBL5182873 IC50 885.0 nM
CSc1sc(C(=O)Nc2ccon2)c2c1-c1sncc1CC2 CHEMBL4065027 EC50 890.0 nM
CN1c2ccc(N)cc2C(c2ccccc2)c2cc(N)ccc21 CHEMBL1991734 pKi 1000.0 nM
CCN(CC)CCNC(=O)c1cccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2cccc3ccccc23)c1 CHEMBL1970290 pKi 1000.0 nM
CC(C)(C)c1cc(NC(=O)C(=O)c2cccc3ccccc23)n(-c2ccc(OCC(N)=O)cc2)n1 CHEMBL1977634 pKi 1000.0 nM
Nc1cc2c(Oc3ccc(Cl)cc3)cncc2s1 CHEMBL2002471 pKi 1000.0 nM
COc1cc(-c2ccc3c(c2)Nc2ccc([N+](=O)[O-])cc2NC3=O)ccc1O CHEMBL1995740 pKi 1000.0 nM
CCN(CCN)C(=O)c1cccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2cccc3ccccc23)c1 CHEMBL2004637 pKi 1000.0 nM
CCOC(=O)c1c(C)n(-c2ccc(I)cc2)c2c1cc(O)c1ccccc12 CHEMBL1970352 pKi 1000.0 nM
Cc1ccc(C)c(NC(=O)c2cc(-c3ccco3)nc3ccccc23)c1 CHEMBL1984296 pKi 1000.0 nM
CN1C(=O)[C@@H](N2CCc3cn(Cc4ccccc4)nc3C2=O)COc2ccccc21 CHEMBL4088216 pIC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3c(nn(Cc4ccccc4)c3Br)C2=O)COc2ccccc21 CHEMBL4549667 pIC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3cn(CC4CCS(=O)(=O)CC4)nc3C2=O)COc2ccccc21 CHEMBL4097778 pIC50 1000.0 nM