COc1ccc(F)cc1-c1cc(NC(=O)COc2ccc(Cl)cn2)ncn1 CHEMBL3694408 IC50 0.005 nM
COc1ccc(F)cc1-c1cc(NC(=O)Cc2cccnc2)ncn1 CHEMBL3694406 IC50 0.015 nM
COc1ccc(F)cc1-c1cc(NC(=O)C2CCCNC2)ncn1 CHEMBL3694400 IC50 0.018 nM
COc1ccccc1-c1cc(NC(=O)C2CCC(=O)NC2)ncn1 CHEMBL3694402 IC50 0.019 nM
COc1ccc(F)cc1-c1cc(NC(=O)Cc2ccncc2)ncn1 CHEMBL3694407 IC50 0.029 nM
COc1cccc(F)c1-c1cc(NC(=O)C2CCCNC2)ncn1 CHEMBL3694401 IC50 0.039 nM
COc1ccccc1-c1cc(NC(=O)c2ccc(C)c(NS(C)(=O)=O)c2)ncn1 CHEMBL3694404 IC50 0.116 nM
CC(C)n1cc(-c2ccnc3[nH]c(C4CCN(CC(=O)N5CCCCC5)CC4)cc23)ccc1=O CHEMBL5197170 Kd 0.213 nM
CN(C)C/C=C/C(=O)N1CCC(C(=O)Nc2ncc(SCc3ncc(C(C)(C)C)o3)s2)CC1 CHEMBL4777844 IC50 0.495 nM
CN1CCC(c2c(O)cc(O)c3c(=O)cc(-c4ccccc4Cl)oc23)C(O)C1 CHEMBL422897 pKi 0.631 nM
CCc1cnn2c(NCc3ccc[n+]([O-])c3)cc(N3CCCCC3CCO)nc12 CHEMBL2006674 pKi 0.7943 nM
COc1cc(CS(C)(=O)=NC#N)cc(Nc2ncc(F)c(-c3ccc(F)cc3OC)n2)c1 CHEMBL3934141 IC50 1.0 nM
CN1C/C=C/CCOc2cccc(c2)-c2ccnc(n2)Nc2cccc(c2)C1 CHEMBL1944698 Kd apparent 1.0 nM
CCc1cnn2c(NCc3ccc[n+]([O-])c3)cc(N3CCCC[C@H]3CCO)nc12 CHEMBL2103840 IC50 1.0 nM
COCCN1CCN(Cc2ccc(-c3n[nH]c4c3C(=O)c3c(NC(=O)NN5CCOCC5)cccc3-4)cc2)CC1 CHEMBL3545083 IC50 1.0 nM
COc1ccccc1-c1cc(NC(=O)c2cccc(NS(C)(=O)=O)c2)ncn1 CHEMBL3694405 IC50 1.08 nM
COc1ccc(F)cc1-c1ccnc2[nH]c(C3=CCN(CC(O)CO)CC3)cc12 CHEMBL3668457 IC50 1.2 nM
COc1ccccc1-c1cc(NC(=O)c2ccc(NS(C)(=O)=O)cc2)ncn1 CHEMBL3694403 IC50 1.25 nM
OC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1986943 pKi 1.259 nM
COc1cc(F)ccc1-c1cc(Nc2cc(CS(C)(=O)=O)ccn2)ncc1F CHEMBL5087022 Kd 1.3 nM
Cc1ccc([N+](=O)[O-])cc1S(=O)(=O)N(C)/N=C/c1cnc2ccc(Br)cn12 CHEMBL393525 IC50 1.4 nM
CN1CC[C@@H](c2c(O)cc(O)c3c(=O)cc(-c4ccc(C(F)(F)F)cc4Cl)oc23)[C@@H]1CO CHEMBL3905910 IC50 1.7 nM
C=CC(=O)Nc1ccc(C(=O)N2CCCC(C(=O)Nc3ncc(SCc4ncc(C(C)(C)C)o4)s3)C2)cc1 CHEMBL4644893 IC50 1.79 nM
CN1CC[C@H](c2c(O)cc(O)c3c(=O)cc(/C=C/c4c(Cl)cccc4Cl)oc23)[C@H](O)C1 CHEMBL4079206 IC50 1.9 nM
Cn1cc(Nc2ncc(Br)c(Nc3ccccc3C(N)=O)n2)cn1 CHEMBL1994669 pKi 1.995 nM
Fc1cccc(CNc2nc(-c3ccnc4[nH]c(C5CCNCC5)cc34)c(F)cc2F)c1 CHEMBL3673540 IC50 2.0 nM
CNC(=O)N1CC=C(c2cc3c(-c4cncc(OCc5cccc(F)c5)n4)ccnc3[nH]2)CC1 CHEMBL3673541 IC50 2.0 nM
O=C(CO)N1CC=C(c2cc3c(-c4cncc(OCc5cccc(F)c5)n4)ccnc3[nH]2)CC1 CHEMBL3673542 IC50 2.0 nM
CCS(=O)(Cc1cccc(Nc2ncc(F)c(-c3ccc(F)cc3OC)n2)c1)=NC#N CHEMBL3959283 IC50 2.0 nM
COc1cc(F)ccc1-c1nc(Nc2cc(F)c(F)c(CS(C)(=O)=NC#N)c2)ncc1F CHEMBL3973367 IC50 2.0 nM
COc1cc(F)ccc1-c1nc(Nc2cc(Br)cc(CS(C)(=N)=O)c2)ncc1F CHEMBL3946675 IC50 2.0 nM
COc1cc(F)ccc1-c1nc(Nc2cc(CS(C)(=N)=O)cc(C(F)(F)F)c2)ncc1F CHEMBL3905335 IC50 2.0 nM
CCS(=O)(Cc1cc(F)cc(Nc2ncc(F)c(-c3ccc(F)cc3OC)n2)c1)=NC#N CHEMBL3979266 IC50 2.0 nM
COc1cc(F)ccc1-c1nc(Nc2cccc(CS(=O)(=NC#N)C3CC3)c2)ncc1F CHEMBL3944304 IC50 2.0 nM
CS(=N)(=O)Cc1cccc(Nc2ncc(F)c(-c3ccc(F)cc3OCc3ccccc3)n2)c1 CHEMBL3927078 IC50 2.0 nM
COc1cc(F)ccc1-c1nc(Nc2cc(Br)cc(CS(C)(=O)=NC#N)c2)ncc1F CHEMBL3919796 IC50 2.0 nM
COc1cc(F)ccc1-c1nc(Nc2cc(Cl)cc(CS(C)(=O)=NC#N)c2)ncc1F CHEMBL3967588 IC50 2.0 nM
COc1cc(F)ccc1-c1nc(Nc2cc(C)cc(CS(C)(=O)=NC#N)c2)ncc1F CHEMBL3953160 IC50 2.0 nM
CN(C)C(=O)c1cc2cnc(Nc3ccc(-c4csc5c(=O)cc(N6CCOCC6)oc45)cc3)nc2n1C1CCCC1 CHEMBL5190816 IC50 2.0 nM
c1ccc(Nc2ncc(-c3ccnc(OC4CCCCC4)n3)s2)nc1 CHEMBL424696 IC50 2.5 nM
CS(=O)(=O)NC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1980562 pKi 2.512 nM
Cn1cc(Nc2ncc(Cl)c(Nc3ccccc3C(N)=O)n2)cn1 CHEMBL1984548 pKi 2.512 nM
COc1ccc(F)cc1-c1c(F)cnc2[nH]c(C3=CCN([C@H]4CC[C@H](C(=O)O)CC4)CC3)cc12 CHEMBL4777981 IC50 2.6 nM
CN1CC[C@H](c2c(O)cc(O)c3c(=O)cc(-c4ccccc4Cl)oc23)[C@H](O)C1 CHEMBL428690 Ki 3.0 nM
COc1cc(F)ccc1-c1ccnc(NC(=O)[C@H]2CCC[C@@H](NC(C)=O)C2)c1 CHEMBL3673434 IC50 3.0 nM
COc1cc(F)ccc1-c1nc(Nc2cccc(CS(C)(=O)=NC#N)c2)ncc1F CHEMBL3960348 IC50 3.0 nM
COc1cc(CS(C)(=N)=O)cc(Nc2ncc(F)c(-c3ccc(F)cc3OC)n2)c1 CHEMBL3960677 IC50 3.0 nM
COCCOC(=O)N=S(C)(=O)Cc1cc(F)cc(Nc2ncc(F)c(-c3ccc(F)cc3OC)n2)c1 CHEMBL3932396 IC50 3.0 nM
COc1cc(F)ccc1-c1cc(Nc2cc(CS(C)(=N)=O)ccn2)ncc1F CHEMBL4756595 IC50 3.0 nM
C=CC(=O)N1CCC(C(=O)Nc2ncc(SCc3ncc(C(C)(C)C)o3)s2)CC1 CHEMBL4641226 IC50 3.16 nM
CNCC(=O)NC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1996980 pKi 3.162 nM
CNC(=O)NC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL2005509 pKi 3.162 nM
Nc1cc(-c2c[nH]c3ncccc23)cc(Cl)n1 CHEMBL1987448 pKi 3.981 nM
NC(=O)c1cc(-c2ccnc(N)n2)[nH]c1-c1ccc(Cl)cc1Cl CHEMBL1965660 pKi 3.981 nM
CCNC(=O)NC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1992220 pKi 3.981 nM
Cc1nc(N)sc1-c1ccnc(Nc2cccc([N+](=O)[O-])c2)n1 CHEMBL298445 Ki 4.0 nM
CC(C)(C)c1cnc(CSc2cnc(NC(=O)C3CCNCC3)s2)o1 CHEMBL296468 Ki 4.0 nM
COc1cc(F)ccc1-c1nc(Nc2cc(F)c(F)c(CS(C)(=N)=O)c2)ncc1F CHEMBL3897217 IC50 4.0 nM
CCOc1cc(F)ccc1-c1nc(Nc2cc(F)cc(CS(C)(=N)=O)c2)ncc1F CHEMBL3959867 IC50 4.0 nM
COc1cc(F)ccc1-c1nc(Nc2cc(CS(C)(=O)=NC#N)cc(C(F)(F)F)c2)ncc1F CHEMBL3937866 IC50 4.0 nM
CCS(=N)(=O)Cc1cc(F)cc(Nc2ncc(F)c(-c3ccc(F)cc3OC)n2)c1 CHEMBL3917892 IC50 4.0 nM
COc1cc(F)ccc1-c1nc(Nc2cc(F)cc(CS(=O)(=NC#N)C3CC3)c2)ncc1F CHEMBL3949630 IC50 4.0 nM
CS(=N)(=O)Cc1cccc(Nc2ncc(F)c(-c3ccc(F)cc3OCc3ccc(F)cc3)n2)c1 CHEMBL3892881 IC50 4.0 nM
CSc1sc(C(N)=O)c2c1-c1sncc1CC2 CHEMBL4082469 IC50 4.0 nM
Cc1cnn2c(NCc3ccc[n+]([O-])c3)cc(N3CCCC[C@@H]3CCO)nc12 CHEMBL4292930 IC50 4.0 nM
Cn1ncc(-c2nc(N[C@H]3CC[C@H](N)CC3)ncc2Cl)c1CC1CC1 CHEMBL4754493 Kd 4.0 nM
COc1cc(C(=O)N2CCCC2)ccc1-c1ccnc2[nH]c(C3CCNCC3)cc12 CHEMBL5170524 IC50 4.0 nM
COc1cc(C(=O)N2CCCC2)ccc1-c1ccnc2[nH]c(C3CCN(CCO)CC3)cc12 CHEMBL5192311 IC50 4.0 nM
CC(C)n1cc(-c2ccnc3[nH]c(C4CCN(CC(=O)N(C)C)CC4)cc23)cnc1=O CHEMBL5179773 IC50 4.0 nM
CCc1cnn2c(NCc3ccc[n+]([O-])c3)cc(C3CCCC[C@H]3CCO)nc12 CHEMBL5171657 IC50 4.0 nM
CC(C)(C)c1coc(CSc2cnc(NC(=O)C3CCNCC3)s2)n1 CHEMBL5273925 IC50 4.0 nM
CCc1cnn2c(NCc3ccc[n+]([O-])c3)cc(N3CCCC[C@@H]3CCO)nc12 CHEMBL5266005 IC50 4.0 nM
Cc1n[nH]c2ncc(C(=O)N3CCC[C@H]3c3ccc(Cl)cc3)cc12 CHEMBL3903492 IC50 4.0 nM
CN(C)CC/C=C/C(=O)Nc1ccc(C(=O)N2CCCC(C(=O)Nc3ncc(SCc4ncc(C(C)(C)C)o4)s3)C2)cc1 CHEMBL4753717 IC50 4.4 nM
c1ccc(CNc2cncc(-c3ccnc4[nH]c(C5CCNCC5)cc34)n2)cc1 CHEMBL3673501 IC50 5.0 nM
Fc1cc(F)cc(CNc2cncc(-c3ccnc4[nH]c(C5CCNCC5)cc34)n2)c1 CHEMBL3673503 IC50 5.0 nM
COc1cc(F)ccc1-c1nc(Nc2cc(F)cc(CS(C)(=N)=O)c2)ncc1F CHEMBL3962241 IC50 5.0 nM
COc1cc(F)ccc1-c1nc(Nc2cccc(CS(C)(=N)=O)c2)ncc1F CHEMBL3965161 IC50 5.0 nM
CCS(=N)(=O)Cc1cccc(Nc2ncc(F)c(-c3ccc(F)cc3OC)n2)c1 CHEMBL3976450 IC50 5.0 nM
CCOc1cc(F)ccc1-c1nc(Nc2cc(F)cc(CS(C)(=O)=NC#N)c2)ncc1F CHEMBL3923419 IC50 5.0 nM
COc1cc(F)ccc1-c1nc(Nc2cc(Cl)cc(CS(C)(=N)=O)c2)ncc1F CHEMBL3981911 IC50 5.0 nM
COc1cc(F)ccc1-c1nc(Nc2cc(CS(C)(=N)=O)cc(C(F)(F)C(F)(F)F)c2)ncc1F CHEMBL3912866 IC50 5.0 nM
C[C@H](CO)Nc1nc(Nc2ccc(S(N)(=O)=O)cc2)ncc1Br CHEMBL4741442 IC50 5.0 nM
C[C@@H](O)[C@@H](C)Oc1nc(Nc2ccc(S(=N)(=O)C3CC3)cc2)ncc1C(F)(F)F CHEMBL4442620 IC50 5.0 nM
Nc1nc(C[C@H]2CC3CCC2C3)sc1C(=O)c1ccccc1[N+](=O)[O-] CHEMBL4761602 IC50 5.0 nM
Nc1nc(N[C@H]2CC3CCC2C3)sc1C(=O)c1ccccc1[N+](=O)[O-] CHEMBL5202522 IC50 5.0 nM
COc1ccccc1-c1cc(Nc2cccc(CS(N)(=O)=O)c2)ncn1 CHEMBL3263773 IC50 5.0 nM
C[C@H](CO)Nc1nc(Nc2ccc(S(N)(=O)=O)cc2)ncc1Br CHEMBL4764656 IC50 5.0 nM
CN(C)CC(=O)NC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1982271 pKi 5.012 nM
CC(C)(CN)CNc1nc(Cl)cc(-c2c[nH]c3ncccc23)n1 CHEMBL1968930 pKi 5.012 nM
CN(C)C1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1969151 pKi 5.012 nM
Cn1ncc(-c2nc(N[C@H]3CC[C@H](N)CC3)ncc2F)c1CC1CC1 CHEMBL4632717 Kd 5.4 nM
O=C(NC1CCNCC1)c1n[nH]cc1NC(=O)c1c(Cl)cccc1Cl CHEMBL445813 Kd 5.8 nM
CC(C)N1c2cc(Nc3nccc(-c4cccc(N)c4)n3)ccc2N(C)C(=O)[C@H]1C CHEMBL4755696 IC50 5.9 nM
CNc1nc(C)c(-c2ccnc(Nc3cc(OC)c(OC)c(OC)c3)n2)s1 CHEMBL1083152 Ki 6.0 nM
O=C(CO)N1CCC(c2cc3c(-c4nc(NCc5cccc(F)c5)c(F)cc4F)ccnc3[nH]2)CC1 CHEMBL3673545 IC50 6.0 nM
COCCNC(=O)Nc1nc2cc(OS(=O)(=O)c3c(F)cccc3F)ccc2[nH]1 CHEMBL4448572 IC50 6.0 nM
COc1cc(F)ccc1-c1cc(Nc2cc(C[S@](C)(=N)=O)ccn2)ncc1F CHEMBL4589249 IC50 6.0 nM
COc1cc(F)ccc1-c1ccnc2[nH]c(C3CCNCC3)cc12 CHEMBL3663760 IC50 6.0 nM
CC(C)n1cc(-c2ccnc3[nH]c(C4CCN(CC(=O)N5CCCC5)CC4)cc23)ccc1=O CHEMBL5207871 IC50 6.0 nM
COc1cc(F)ccc1-c1ccnc2[nH]c(C3CCN(CC(=O)N(C)C)CC3)cc12 CHEMBL5195947 IC50 6.0 nM
CCC(CC)c1cc(N[C@H]2CC[C@H](N)C2)n2nccc2n1 CHEMBL5199065 IC50 6.0 nM
COc1cc(F)ccc1-c1ncnc(Nc2cccc(C[S@@](C)(=N)=O)c2)n1 CHEMBL4560679 IC50 6.0 nM
NC(=O)c1cc(-c2ccnc(N)n2)[nH]c1-c1ccc(Cl)cc1F CHEMBL1981079 pKi 6.31 nM
Fc1cccc(COc2cncc(-c3ccnc4[nH]c(C5=CCNCC5)cc34)n2)c1 CHEMBL3673532 IC50 7.0 nM
CNC(=O)N=S(C)(=O)Cc1cccc(Nc2ncc(F)c(-c3ccc(F)cc3OC)n2)c1 CHEMBL3916775 IC50 7.0 nM
COc1cc(F)ccc1-c1nc(Nc2cc(F)cc(CS(=N)(=O)C3CC3)c2)ncc1F CHEMBL3934257 IC50 7.0 nM
COc1ccc(CNc2cc(-c3c[nH]c4ncccc34)cc(F)n2)cc1 CHEMBL1986855 pKi 7.943 nM
CN1CCC(c2cc3c(-c4cc(NCc5ccc(S(C)(=O)=O)cc5)ccc4F)ccnc3[nH]2)CC1 CHEMBL3668461 IC50 8.0 nM
Fc1cccc(CNc2ccc(Cl)c(-c3ccnc4[nH]c(C5CCCNC5)cc34)n2)c1 CHEMBL3668473 IC50 8.0 nM
CS(=O)(=O)N1CC=C(c2cc3c(-c4cncc(OCc5cccc(F)c5)n4)ccnc3[nH]2)CC1 CHEMBL3673539 IC50 8.0 nM
CCOC(=O)N=S(C)(=O)Cc1cccc(Nc2ncc(F)c(-c3ccc(F)cc3OC)n2)c1 CHEMBL3906489 IC50 8.0 nM
CS(=N)(=O)Cc1cccc(Nc2ncc(F)c(-c3cccc4c3OCCC4)n2)c1 CHEMBL3978185 IC50 8.0 nM
CCOC(=O)N=S(C)(=O)Cc1cc(F)cc(Nc2ncc(F)c(-c3ccc(F)cc3OC)n2)c1 CHEMBL3934755 IC50 8.0 nM
COc1cc(F)ccc1-c1nc(Nc2cc(CS(C)(=O)=NC#N)cc(C(F)(F)C(F)(F)F)c2)ncc1F CHEMBL3984385 IC50 8.0 nM
CC(C)n1nc(-c2ccnc3[nH]c(C4CCN(CC(=O)N(C)C)CC4)cc23)ccc1=O CHEMBL5204473 IC50 8.0 nM
CN(C)C/C=C/C(=O)Nc1ccc(C(=O)Nc2ncc(SCc3ncc(C(C)(C)C)o3)s2)cc1 CHEMBL4756353 IC50 8.9 nM
CC(C)c1nn(-c2c(Cl)cccc2Cl)c2nc(Cc3ccc(OCCO)cc3)[nH]c(=O)c12 CHEMBL258721 IC50 9.0 nM
CCNc1nc(C)c(-c2ccnc(Nc3ccc(CNC(C)=O)cc3)n2)s1 CHEMBL1084715 Ki 9.0 nM
NC1CCCC(c2cc3c(-c4cccc(NCc5cccc(F)c5)n4)ccnc3[nH]2)C1 CHEMBL3673494 IC50 9.0 nM
Fc1ccc(CNc2cncc(-c3ccnc4[nH]c(C5CCNCC5)cc34)n2)cc1F CHEMBL3673507 IC50 9.0 nM
Fc1cccc(CNc2cncc(-c3ccnc4[nH]c(C5=CCNCC5)cc34)n2)c1 CHEMBL3673530 IC50 9.0 nM
O=C(CO)N1CC=C(c2cc3c(-c4cncc(NCc5cccc(F)c5)n4)ccnc3[nH]2)CC1 CHEMBL3673538 IC50 9.0 nM
CCOC(=O)N=S(C)(=O)Cc1cccc(Nc2ncc(F)c(-c3ccc(F)cc3OCc3ccccc3)n2)c1 CHEMBL3900262 IC50 9.0 nM
CCOC(=O)N=S(C)(=O)Cc1cccc(Nc2ncc(F)c(-c3cccc4c3OCC4)n2)c1 CHEMBL3972796 IC50 9.0 nM
COc1cc(C(=O)N2CCCC2)ccc1-c1ccnc2[nH]c(-c3ccc(CN4CCOCC4)cc3)nc12 CHEMBL5173041 IC50 9.0 nM
COc1cc(/C=C/C(=O)N2CCC=CC2=O)cc(OC)c1OCCN1CCN(C(=O)CN2CCC(C(=O)Nc3ncc(SCc4ncc(C(C)(C)C)o4)s3)CC2)CC1 CHEMBL5218576 DC50 9.0 nM
O=C1NCCc2[nH]c(-c3ccncc3)cc21 CHEMBL225519 pKi 10.0 nM
COc1cc(F)ccc1-c1ccnc(NC(=O)C2CCC(NC(C)=O)C2)c1 CHEMBL3673435 IC50 10.0 nM
COc1ccccc1-c1cc(N(C)C(=O)[C@@H]2CCCNC2)ncn1 CHEMBL3694399 IC50 10.0 nM
Fc1cncc(CNc2ccc(Cl)c(-c3ccnc4[nH]c(C5CCNCC5)cc34)n2)c1 CHEMBL3663778 IC50 10.0 nM
COc1ccc(F)cc1-c1ccnc2[nH]c(C3=CCNCC3)cc12 CHEMBL3668361 IC50 10.0 nM
Fc1cccc(CNc2cncc(-c3ccnc4[nH]c(C5CCNCC5)cc34)n2)c1 CHEMBL3673504 IC50 10.0 nM
CN1CCC(c2cc3c(-c4cncc(NCc5ccccc5)n4)ccnc3[nH]2)CC1 CHEMBL3673512 IC50 10.0 nM
CNC(=O)N1CCC(c2cc3c(-c4nc(NCc5cccc(F)c5)c(F)cc4F)ccnc3[nH]2)CC1 CHEMBL3673544 IC50 10.0 nM
CCOc1ccccc1CNc1nc(C)nc2[nH]cc(-c3ccnc(N)c3)c12 CHEMBL4294976 IC50 10.0 nM
CC(=O)N[C@@H]1CCC[C@H](C(=O)Nc2cc(-c3cnn4c3CC(C)(C)CC4)c(F)cn2)C1 CHEMBL4752748 IC50 10.0 nM
CN(C)C(=O)CN1CCC(c2cc3c(-c4ccc(=O)n(C)c4)ccnc3[nH]2)CC1 CHEMBL5207813 IC50 10.0 nM
COc1cc(F)ccc1-c1ccnc2[nH]c(C3CCN(C)CC3)cc12 CHEMBL3663770 IC50 10.0 nM
CNC(=O)CN1CCC(c2cc3c(-c4ccc(=O)n(C(C)C)c4)ccnc3[nH]2)CC1 CHEMBL5177440 IC50 10.0 nM
CN(C)C/C=C/C(=O)Nc1cccc(C(=O)Nc2ncc(SCc3ncc(C(C)(C)C)o3)s2)c1 CHEMBL4786429 IC50 10.7 nM
COc1cc(Nc2nccc(-c3sc(C)nc3C)n2)cc(OC)c1OC CHEMBL1083151 Ki 11.0 nM
COc1ccc(F)cc1-c1ccnc2[nH]c(C3CCNCC3)cc12 CHEMBL3663759 IC50 11.0 nM
Fc1ccc(NCc2ccccc2)cc1-c1ccnc2[nH]c(C3CCCNC3)cc12 CHEMBL3668476 IC50 11.0 nM
O=C(CO)N1CCC(c2cc3c(-c4cncc(NCc5cccc(F)c5)n4)ccnc3[nH]2)CC1 CHEMBL3673509 IC50 11.0 nM
OCC(O)CN1CCC(c2cc3c(-c4cncc(OCc5cccc(F)c5)n4)ccnc3[nH]2)CC1 CHEMBL3673523 IC50 11.0 nM
CNC(=O)C1CC=C(c2cc3c(-c4cncc(NCc5ccccc5)n4)ccnc3[nH]2)CC1 CHEMBL3673547 IC50 11.0 nM
COc1cc(C(=O)N2CCCC2)ccc1-c1ccnc2[nH]c(C3CCN(C(C)=O)CC3)cc12 CHEMBL5207146 IC50 11.0 nM
CSCCn1cc(-c2ccnc3[nH]c(C4CCN(CC(=O)N(C)C)CC4)cc23)ccc1=O CHEMBL5198372 IC50 11.0 nM
CC(C)c1c2cc(-c3ccnc(N[C@H]4CC[C@H](NC5CCOCC5)CC4)n3)ccc2nn1C CHEMBL3940387 IC50 11.0 nM
COc1cc(F)c(F)cc1-c1ccnc2[nH]c(C3CCNCC3)cc12 CHEMBL3663764 IC50 12.0 nM
CN1CCC(c2cc3c(-c4cccc(NCc5c(F)cccc5F)n4)ccnc3[nH]2)CC1 CHEMBL3668375 IC50 12.0 nM
COc1ccc(F)cc1-c1ccnc2[nH]c(C3CNC3)cc12 CHEMBL3668418 IC50 12.0 nM
Fc1cccc(COc2cncc(-c3ccnc4[nH]c(C5CCNCC5)cc34)n2)c1 CHEMBL3673517 IC50 12.0 nM
Cc1ccccc1-c1c(-c2ccc3[nH]nc(N)c3c2)nnn1Cc1ccccc1 CHEMBL2000029 pKi 12.59 nM
O=C1Cc2c([nH]c3ccc([N+](=O)[O-])cc23)-c2ccccc2N1 CHEMBL50894 pKi 12.59 nM
CNC1CC2OC(C)(C1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL1980995 pKi 12.59 nM
Nc1nc(Cl)cc(-c2c[nH]c3ncccc23)n1 CHEMBL2007574 pKi 12.59 nM
CN1CCC(c2cc3c(-c4cccc(NCc5ccc6c(c5)OCO6)n4)ccnc3[nH]2)CC1 CHEMBL3668378 IC50 13.0 nM
CN1CCC(c2cc3c(-c4cncc(OCc5cccc(F)c5)n4)ccnc3[nH]2)CC1 CHEMBL3673520 IC50 13.0 nM
Cc1nc2ccc(-c3ccnc4[nH]c(C5CCN(CC(=O)N(C)C)CC5)cc34)cc2n1C(C)C CHEMBL5181709 IC50 13.0 nM
CC(=O)N[C@@H]1CCC[C@H](C(=O)Nc2cc(-c3cnn4c3CC(C)(C)C4)c(Cl)cn2)C1 CHEMBL4462530 IC50 13.4 nM
CC(C)N1c2cc(Nc3nccc(-c4cccc5[nH]ccc45)n3)ccc2N(C)C(=O)[C@H]1C CHEMBL4798556 IC50 13.8 nM
Clc1cnc(NCc2ccccc2)cc1-c1ccnc2[nH]c(C3CCNCC3)cc12 CHEMBL3663792 IC50 14.0 nM
CN1CCC(c2cc3c(-c4cccc(NCc5cccc(Cl)c5)n4)ccnc3[nH]2)CC1 CHEMBL3668370 IC50 14.0 nM
COc1ccc(F)cc1-c1ccnc2[nH]c(C3CCN(Cc4cccnc4)C3)cc12 CHEMBL3668385 IC50 14.0 nM
COc1ccc(F)cc1-c1ccnc2[nH]c(C3CCCN(CCCN)C3)cc12 CHEMBL3668401 IC50 14.0 nM
CN1CCC(c2cc3c(-c4cncc(NCc5cccc(F)c5)n4)ccnc3[nH]2)CC1 CHEMBL3673518 IC50 14.0 nM
CCOC(=O)NS(=O)(=O)N1CCC(c2cc3c(-c4cncc(NCc5cccc(F)c5)n4)ccnc3[nH]2)CC1 CHEMBL3673524 IC50 14.0 nM
OCC(O)CN1CC=C(c2cc3c(-c4cncc(NCc5cccc(F)c5)n4)ccnc3[nH]2)CC1 CHEMBL3673531 IC50 14.0 nM
CCOC(=O)N=S(C)(=O)Cc1cccc(Nc2ncc(F)c(-c3cccc4c3OCCC4)n2)c1 CHEMBL3949057 IC50 14.0 nM
COc1cc(F)ccc1-c1nc(Nc2cccc(CS(=N)(=O)C3CC3)c2)ncc1F CHEMBL3921855 IC50 14.0 nM
CC(C)n1cc(-c2ccnc3[nH]c(C4CCN(Cc5cccs5)CC4)cc23)ccc1=O CHEMBL5192022 IC50 14.0 nM
COc1ccc(F)c(F)c1C(=O)c1cnc(NC2CCN(S(C)(=O)=O)CC2)nc1N CHEMBL384304 Kd 15.0 nM
COc1ccc(F)cc1-c1ccnc2[nH]c([C@@H]3CCCNC3)cc12 CHEMBL3663746 IC50 15.0 nM
Fc1cccc(CNc2ccc(Cl)c(-c3ccnc4[nH]c(C5CCNCC5)cc34)n2)c1 CHEMBL3663774 IC50 15.0 nM
CN1CCC(c2cc3c(-c4cccc(NCc5ccccc5)n4)ccnc3[nH]2)CC1 CHEMBL3663796 IC50 15.0 nM
CN1CCC(c2cc3c(-c4nc(NCc5cccc(F)c5)ccc4Cl)ccnc3[nH]2)CC1 CHEMBL3663797 IC50 15.0 nM
COc1ccc(F)cc1-c1ccnc2[nH]c([C@@H]3CCNC3)cc12 CHEMBL3663802 IC50 15.0 nM
CN1CCC(c2cc3c(-c4cccc(NCc5cc[nH]n5)n4)ccnc3[nH]2)CC1 CHEMBL3668427 IC50 15.0 nM
Fc1cccc(CNc2cc(-c3ccnc4[nH]c(C5CCNCC5)cc34)c(Cl)cn2)c1 CHEMBL3673493 IC50 15.0 nM
CS(=O)(=O)N1CCC(c2cc3c(-c4cncc(NCc5ccccc5)n4)ccnc3[nH]2)CC1 CHEMBL3673500 IC50 15.0 nM
CCN(C(=O)O)S(=O)(=O)N1CCC(c2cc3c(-c4cncc(NCc5ccccc5)n4)ccnc3[nH]2)CC1 CHEMBL3673515 IC50 15.0 nM
C1=C(c2cc3c(-c4cncc(NCc5ccccc5)n4)ccnc3[nH]2)CCNC1 CHEMBL3673521 IC50 15.0 nM
CC(=O)N[C@@H]1CC[C@H](C(=O)Nc2cc(-c3cnn4c3CC(C)(C)C4)c(Cl)cn2)C1 CHEMBL4784117 EC50 15.0 nM
C=CC(=O)Nc1ccc(C(=O)N2CCCC(Nc3ncc(/C=C/c4ncc(C(C)(C)C)o4)s3)C2)cc1 CHEMBL4753350 IC50 15.1 nM
O=C(O)c1ccccc1Nc1ccnc(Nc2ccc3cn[nH]c3c2)n1 CHEMBL244378 pKi 15.85 nM
CC(C)CNC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL2006456 pKi 15.85 nM
Nc1nc(Nc2ccc(S(N)(=O)=O)cc2)nn1C(=O)c1c(F)cccc1F CHEMBL191003 pKi 15.85 nM
NC1CCCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)C1 CHEMBL1998432 pKi 15.85 nM
COc1ccc(F)cc1-c1ccnc2[nH]c(C3CCCNC3)cc12 CHEMBL3663743 IC50 16.0 nM
COc1cc(F)ccc1-c1ccnc2[nH]c(-c3ccc(CN4CCOCC4)cc3)cc12 CHEMBL5170195 IC50 16.0 nM
CCC1CNC(=O)c2cc(-c3ccnc(N)n3)[nH]c21 CHEMBL526092 IC50 17.0 nM
COc1ccccc1-c1cc(Nc2ccc(F)c(NS(C)(=O)=O)c2)ncn1 CHEMBL3895785 Ki 17.0 nM
COc1ccc(F)cc1-c1ccnc2[nH]c(C3CCN(C)CC3)cc12 CHEMBL3663769 IC50 17.0 nM
Fc1ccc(F)c(CNc2ccc(Cl)c(-c3ccnc4[nH]c(C5CCNCC5)cc34)n2)c1 CHEMBL3663777 IC50 17.0 nM
COc1ccc(F)cc1-c1ccnc2[nH]c(C3CCNC3)cc12 CHEMBL3663799 IC50 17.0 nM
COc1ccc(F)cc1-c1ccnc2[nH]c(C3CCNCC3)c(C)c12 CHEMBL3668350 IC50 17.0 nM
CN1CCC(c2cc3c(-c4cccc(NCCc5ccccc5)n4)ccnc3[nH]2)CC1 CHEMBL3668421 IC50 17.0 nM
Fc1cncc(CNc2ccc(Cl)c(-c3ccnc4[nH]c(C5CCCNC5)cc34)n2)c1 CHEMBL3668480 IC50 17.0 nM
CNC(=O)N1CC=C(c2cc3c(-c4cncc(NCc5cccc(F)c5)n4)ccnc3[nH]2)CC1 CHEMBL3673533 IC50 17.0 nM
Clc1ccc(NCc2cccnc2)nc1-c1ccnc2[nH]c(C3CCNCC3)cc12 CHEMBL3663775 IC50 18.0 nM
Fc1cnc(NCc2ccccc2)cc1-c1ccnc2[nH]c(C3CCCNC3)cc12 CHEMBL3668481 IC50 18.0 nM
O=C(O)C1CC=C(c2cc3c(-c4cncc(OCc5cccc(F)c5)n4)ccnc3[nH]2)CC1 CHEMBL3673549 IC50 18.0 nM
COc1cc(Cl)ccc1-c1ccnc2[nH]c(C3CCNCC3)cc12 CHEMBL3663761 IC50 19.0 nM
Fc1ccc(CNc2ccc(Cl)c(-c3ccnc4[nH]c(C5CCNCC5)cc34)n2)cc1F CHEMBL3663780 IC50 19.0 nM
CN1CCC(c2cc3c(-c4nc(NCc5ccccc5)ccc4Cl)ccnc3[nH]2)CC1 CHEMBL3663794 IC50 19.0 nM
COc1ccc(F)cc1-c1ccnc2[nH]c(C3CCN(C(=O)CN4CCOCC4)CC3)cc12 CHEMBL3668452 IC50 19.0 nM
CNC(=O)N1CC=C(c2cc3c(-c4cc(F)ccc4OC)ccnc3[nH]2)CC1 CHEMBL3668485 IC50 19.0 nM
CCN(C(=O)O)S(=O)(=O)N1CC=C(c2cc3c(-c4cc(F)ccc4OC)ccnc3[nH]2)CC1 CHEMBL3668497 IC50 19.0 nM
CNC(=O)N1CCC(c2cc3c(-c4cncc(NCc5cccc(F)c5)n4)ccnc3[nH]2)CC1 CHEMBL3673526 IC50 19.0 nM
COc1cc(F)ccc1-c1ccnc2[nH]c(-c3ccc(CN4CCOCC4)cc3)nc12 CHEMBL5188442 IC50 19.0 nM
CC(C)N1c2cc(Nc3nccc(-c4ccnc5ccccc45)n3)ccc2N(C)C(=O)[C@H]1C CHEMBL4762677 IC50 19.8 nM
Cc1cc(=O)n2ccc(CN(C)C)c(O)c2n1 CHEMBL1988581 pKi 19.95 nM
Clc1ccccc1CNc1cccc(-c2ccnc3[nH]c(C4CCNCC4)cc23)n1 CHEMBL3668412 IC50 20.0 nM
Fc1ccc(CNc2ccc(Cl)c(-c3ccnc4[nH]c(C5CCCNC5)cc34)n2)cc1F CHEMBL3668472 IC50 20.0 nM
Fc1ccc2c(c1)-c1ccnc3[nH]c(C4=CCNCC4)c(c13)CO2 CHEMBL3901726 IC50 20.0 nM
Clc1ccnc2[nH]c(-c3ccc(N4CCNCC4)cc3)cc12 CHEMBL4084410 IC50 20.0 nM
FC(F)(F)c1cnc(N[C@H]2CCCNC2)nc1-c1n[nH]c2ccccc12 CHEMBL4474655 IC50 20.0 nM
Clc1cnc(NC2CCCCC2)nc1-c1c[nH]c2cccnc12 CHEMBL4465061 IC50 20.0 nM
Cc1ncc(-c2ccnc(Nc3ccc(S(C)(=O)=O)cc3)n2)n1C(C)C CHEMBL488436 IC50 20.0 nM
CN1CC[C@@H](c2c(O)cc(O)c3c(=O)cc(-c4ccccc4Cl)oc23)[C@@H]1CO CHEMBL3991935 IC50 20.0 nM
Clc1ccc(NCc2ccccc2)nc1-c1ccnc2[nH]c(C3CCNCC3)cc12 CHEMBL3663773 IC50 21.0 nM
Clc1ccc(CNc2ccc(Cl)c(-c3ccnc4[nH]c(C5CCNCC5)cc34)n2)cc1 CHEMBL3663776 IC50 21.0 nM
CN(Cc1ccccc1)c1ccc(Cl)c(-c2ccnc3[nH]c(C4CCNCC4)cc23)n1 CHEMBL3663786 IC50 21.0 nM
COc1ccc(F)cc1-c1ccnc2[nH]c(C3CCCN(CCO)C3)cc12 CHEMBL3668400 IC50 21.0 nM
COc1ccc(F)cc1-c1ccnc2[nH]c(C3CCN(S(C)(=O)=O)CC3)cc12 CHEMBL3639672 IC50 21.0 nM
COc1ccc(F)cc1-c1ccnc2[nH]c(C3CCN(CC(O)CO)CC3)cc12 CHEMBL3668420 IC50 21.0 nM
Fc1cc(NCc2ccccc2)nc(-c2ccnc3[nH]c(C4CCCNC4)cc23)c1 CHEMBL3668482 IC50 21.0 nM
Fc1cccc(CNc2ccc(F)c(-c3ccnc4[nH]c(C5CCCNC5)cc34)c2)c1 CHEMBL3668484 IC50 21.0 nM
COc1ccc(F)cc1-c1ccnc2[nH]c(C3=CCN(C(=O)CC#N)CC3)cc12 CHEMBL3668491 IC50 21.0 nM
CC(=O)N1CCC(c2cc3c(-c4cncc(NCc5cccc(F)c5)n4)ccnc3[nH]2)CC1 CHEMBL3673519 IC50 21.0 nM
O=C(O)C1CC=C(c2cc3c(-c4cncc(NCc5ccccc5)n4)ccnc3[nH]2)CC1 CHEMBL3673546 IC50 21.0 nM
CN1Cc2c(C3=CCNCC3)[nH]c3nccc(c23)-c2cc(F)ccc21 CHEMBL3950787 IC50 21.0 nM
COc1ccc(F)cc1-c1ccnc2[nH]c(C3CCNCC3S(C)(=N)=O)cc12 CHEMBL3928559 IC50 22.0 nM
COc1cc(F)ccc1-c1ccnc2[nH]c(C3CCCNC3)cc12 CHEMBL3663744 IC50 22.0 nM
COc1ccc(F)cc1-c1ccnc2[nH]c(C3CCN(C)C3)cc12 CHEMBL3663803 IC50 22.0 nM
COC(=O)CCCN[C@H]1CC[C@H](c2cc3c(-c4cc(F)ccc4OC)ccnc3[nH]2)CC1 CHEMBL3668393 IC50 22.0 nM
COc1ccc(F)cc1-c1ccnc2[nH]c(C3CCN(C(=O)CNC4CCC(O)CC4)CC3)cc12 CHEMBL3668453 IC50 22.0 nM
COc1ccc(F)cc1-c1ccnc2[nH]c(C3CCN(C(=O)CNCCO)CC3)cc12 CHEMBL3668454 IC50 22.0 nM
CNS(=O)(=O)CC(=O)N1CC=C(c2[nH]c3nccc4c3c2CN(C)c2ccc(F)cc2-4)CC1 CHEMBL3967958 IC50 22.0 nM
CNc1cccc(-c2ccnc(Nc3ccc4c(c3)N(C(C)C)[C@H](C)C(=O)N4C)n2)c1 CHEMBL4764023 IC50 22.0 nM
C=CC(=O)NC1CCC(C(=O)N2CCCC(Nc3ncc(SCc4ncc(C(C)(C)C)o4)s3)C2)CC1 CHEMBL4793573 IC50 22.0 nM
CC(C)N1c2cc(Nc3nccc(-c4cncc5ccccc45)n3)ccc2N(C)C(=O)[C@H]1C CHEMBL4742169 IC50 22.4 nM
O=C(CO)N1CC=C(c2cc3c(-c4cncc(NCc5ccccc5)n4)ccnc3[nH]2)CC1 CHEMBL3986015 IC50 23.0 nM
COc1ccc(F)cc1-c1ccnc2[nH]c([C@H]3CCCNC3)cc12 CHEMBL3663745 IC50 23.0 nM
COc1ccc(F)cc1-c1ccnc2[nH]c([C@H]3CCNC3)cc12 CHEMBL3663801 IC50 23.0 nM
COc1ccc(F)cc1-c1ccnc2[nH]c(C3CCCC(N)C3)cc12 CHEMBL3668349 IC50 23.0 nM
COc1ccc(F)cc1-c1ccnc2[nH]c(C3CCN(Cc4ccncc4)C3)cc12 CHEMBL3668386 IC50 23.0 nM
COc1ccc(F)cc1-c1ccnc2[nH]c(C3CCCN(CCCNC(=O)OCc4ccccc4)C3)cc12 CHEMBL3668399 IC50 23.0 nM
COc1ccc(F)cc1-c1ccnc2[nH]c(C3CCN(C(=O)CO)CC3)cc12 CHEMBL3668408 IC50 23.0 nM
COc1ccc(F)cc1-c1ccnc2[nH]c(C3CCN(C(=O)CN4CCCCC4)CC3)cc12 CHEMBL3668451 IC50 23.0 nM
CN1CCC(c2cc3c(-c4cc(NCc5ccncc5)ccc4F)ccnc3[nH]2)CC1 CHEMBL3668460 IC50 23.0 nM
Clc1cnc(NCc2ccccc2)cc1-c1ccnc2[nH]c(C3CCCNC3)cc12 CHEMBL3668475 IC50 23.0 nM
CNC(=O)N1CC=C(c2cc3c(-c4cc(F)c(F)cc4OC)ccnc3[nH]2)CC1 CHEMBL3668500 IC50 23.0 nM
COc1ccc(F)cc1-c1ccnc2[nH]c(C3=CCN(S(C)(=O)=O)CC3)c(C#N)c12 CHEMBL3668515 IC50 23.0 nM
CC(C)N1c2cc(Nc3ncc(Cl)c(-c4cncc5ccccc45)n3)ccc2N(C)C(=O)[C@H]1C CHEMBL4783301 IC50 23.0 nM
C=CC(=O)Nc1ccc(C(=O)Nc2cccc(C(=O)Nc3ncc(SCc4ncc(C(C)(C)C)o4)s3)c2)cc1 CHEMBL4761637 IC50 23.7 nM
CC(C)N1c2cc(Nc3ncc(F)c(-c4cncc5ccccc45)n3)ccc2N(C)C(=O)[C@H]1C CHEMBL4757918 IC50 23.9 nM
Clc1ccc(OCc2ccccc2)nc1-c1ccnc2[nH]c(C3CCNCC3)cc12 CHEMBL3663798 IC50 24.0 nM
COc1ccc(F)cc1-c1ccnc2[nH]c(C3CCC(N)CC3)cc12 CHEMBL3668348 IC50 24.0 nM
CN1CCC(c2cc3c(-c4cccc(NCc5ccccc5Cl)n4)ccnc3[nH]2)CC1 CHEMBL3668413 IC50 24.0 nM
CC(=O)N1CCC(c2cc3c(-c4cncc(OCc5cccc(F)c5)n4)ccnc3[nH]2)CC1 CHEMBL3673528 IC50 24.0 nM
CN1Cc2c(C3=CCN(CCS(N)(=O)=O)CC3)[nH]c3nccc(c23)-c2cc(F)ccc21 CHEMBL3916153 IC50 24.0 nM
C=CC(=O)Nc1cccc(C(=O)Nc2ncc(SCc3ncc(C(C)(C)C)o3)s2)c1 CHEMBL4643057 IC50 24.6 nM
Clc1ccc(NCc2ccncc2)nc1-c1ccnc2[nH]c(C3CCNCC3)cc12 CHEMBL3663781 IC50 25.0 nM
Clc1ccc(NCc2ccccc2)cc1-c1ccnc2[nH]c(C3CCNCC3)cc12 CHEMBL3663793 IC50 25.0 nM
COc1cc(F)ccc1-c1ccnc2[nH]c(C3CCNC3)cc12 CHEMBL3663800 IC50 25.0 nM
Clc1ccc(NCc2ccccc2)nc1-c1ccnc2[nH]c(C3CCNC3)cc12 CHEMBL3663804 IC50 25.0 nM
Clc1cnc2[nH]c(C3CCNCC3)cc2c1-c1cccc(NCc2ccccc2)n1 CHEMBL3668351 IC50 25.0 nM
CN1CCC(c2cc3c(-c4nc(NCC5CCS(=O)(=O)CC5)ccc4Cl)ccnc3[nH]2)CC1 CHEMBL3668445 IC50 25.0 nM
CN1CCC(c2cc3c(-c4cc(NCc5ccc(C(N)=O)cc5)ccc4F)ccnc3[nH]2)CC1 CHEMBL3668462 IC50 25.0 nM
Clc1cnc2[nH]c(C3CCCNC3)cc2c1-c1ccnc(NCc2ccccc2)c1 CHEMBL3668483 IC50 25.0 nM
CS(=O)(Cc1cccc(Nc2ncc(F)c(-c3ccc(F)cc3OCc3ccccc3)n2)c1)=NC#N CHEMBL3892285 IC50 25.0 nM
CN1Cc2c(C3=CCN(S(C)(=O)=O)CC3)[nH]c3nccc(c23)-c2cc(F)ccc21 CHEMBL3923769 IC50 25.0 nM
CN1Cc2c(C3=CCN(CCS(=O)(=O)N(C)C)CC3)[nH]c3nccc(c23)-c2cc(F)ccc21 CHEMBL3891660 IC50 25.0 nM
CC(=O)N[C@@H]1CCC[C@H](C(=O)Nc2cc(-c3cnn4c3CC(C)(C)C4)c(F)cn2)C1 CHEMBL4754081 IC50 25.0 nM
CCOC(=O)NS(=O)(=O)N1CC=C(c2cc3c(-c4cc(F)ccc4OC)ccnc3[nH]2)CC1 CHEMBL4850143 IC50 25.0 nM
CC(C)n1cc(-c2ccnc3[nH]c(C4CCN(CC(=O)N(C)C)CC4)cc23)ccc1=O CHEMBL5198038 IC50 25.0 nM
Clc1cc(-c2c[nH]c3ncccc23)nc(NC2CCOCC2)n1 CHEMBL1980253 pKi 25.12 nM
Cc1cnc(OC2CCCCC2)nc1-c1cnc(Nc2ccccn2)s1 CHEMBL212049 IC50 26.0 nM
COc1cc(F)c(F)cc1-c1ccnc2[nH]c(C3CCCNC3)cc12 CHEMBL3668471 IC50 26.0 nM
CN1CCc2c(C3=CCNCC3)[nH]c3nccc(c23)-c2cc(F)ccc21 CHEMBL3957008 IC50 26.0 nM
Cc1cc(C)c(CNc2nc(N[C@@H](C)[C@@H](C)O)nc3c2ncn3C(C)C)cn1 CHEMBL4579344 IC50 26.0 nM
CC[C@H](Nc1nc(NCc2ccccc2)c2ncn(C(C)C)c2n1)[C@@H](C)O CHEMBL4764173 IC50 26.0 nM
CC[C@H](Nc1nc(NCc2cnc(C)cc2C)c2ncn(C(C)C)c2n1)[C@@H](C)O CHEMBL3655762 IC50 26.0 nM
COc1ccccc1-c1ccnc2[nH]c(C3CCNCC3)cc12 CHEMBL3663768 IC50 27.0 nM
Fc1ccc(CNc2ccc(Cl)c(-c3ccnc4[nH]c(C5CCCNC5)cc34)n2)cc1 CHEMBL3668474 IC50 27.0 nM
COc1ccc(F)cc1-c1ccnc2[nH]c(C3=CCN(C(=O)NC#N)CC3)cc12 CHEMBL3668510 IC50 27.0 nM
O=C(CO)N1CCC(c2cc3c(-c4cncc(OCc5cccc(F)c5)n4)ccnc3[nH]2)CC1 CHEMBL3673522 IC50 27.0 nM
CN1Cc2c(C3=CCNCC3)[nH]c3ncc(F)c(c23)-c2cc(F)ccc21 CHEMBL3960058 IC50 27.0 nM
Nc1nccc(-c2cc3c([nH]2)[C@@H](CCF)CNC3=O)n1 CHEMBL524266 IC50 28.0 nM
COc1ccc(F)cc1-c1ccnc2[nH]c([C@H]3CC[C@H](NCC(O)CO)CC3)cc12 CHEMBL3668395 IC50 28.0 nM
CN1CCC(c2cc3c(-c4nc(NCc5ccc(C(N)=O)cc5)ccc4Cl)ccnc3[nH]2)CC1 CHEMBL3668433 IC50 28.0 nM
COc1ccc(F)cc1-c1ccnc2[nH]c(C3=CCN(CC(N)=O)CC3)cc12 CHEMBL3668496 IC50 28.0 nM
CNC(=O)N1CC=C(c2[nH]c3nccc(-c4cc(F)ccc4OC)c3c2C#N)CC1 CHEMBL3668516 IC50 28.0 nM
OCC(O)CN1CCC(c2cc3c(-c4cncc(NCc5ccccc5)n4)ccnc3[nH]2)CC1 CHEMBL3673514 IC50 28.0 nM
CN1Cc2c(C3=C[C@H](CO)NCC3)[nH]c3nccc(c23)-c2cc(F)ccc21 CHEMBL3955479 IC50 28.0 nM
CC(C)N1CCN(c2ccc(Nc3ncc4cc5n(c4n3)C3(CCCCC3)CNC5=O)nc2)CC1 CHEMBL3904602 IC50 28.0 nM
Nc1nccc(-c2cc3c([nH]2)CCNC3=O)n1 CHEMBL402272 IC50 29.0 nM
CN1CCC(c2cc3c(-c4cccc(NCc5cccnc5)n4)ccnc3[nH]2)CC1 CHEMBL3668364 IC50 29.0 nM
COc1ccc(F)cc1-c1ccnc2[nH]c(C3CCN(CCNC(=O)OC(C)(C)C)C3)cc12 CHEMBL3668388 IC50 29.0 nM
COc1ccc(F)cc1-c1ccnc2[nH]c([C@H]3CC[C@H](NCC4CC4C(=O)O)CC3)cc12 CHEMBL3668417 IC50 29.0 nM
Clc1ccc(NCc2ccccc2)cc1-c1ccnc2[nH]c(C3CCCNC3)cc12 CHEMBL3668469 IC50 29.0 nM
c1cncc(CNc2cncc(-c3ccnc4[nH]c(C5CCNCC5)cc34)n2)c1 CHEMBL3673505 IC50 29.0 nM
CN1Cc2c(C3=CCNCC3)[nH]c3nccc(c23)-c2cc(F)c(F)cc21 CHEMBL3970723 IC50 29.0 nM
c1cc(NCC2CCOCC2)nc(-c2ccnc3[nH]c(C4CCNCC4)cc23)c1 CHEMBL3668362 IC50 30.0 nM
CN1CCC(c2cc3c(-c4cccc(NCCO)n4)ccnc3[nH]2)CC1 CHEMBL3668435 IC50 30.0 nM
COc1ccc(F)cc1-c1ccnc2[nH]c(C3CN(C)C3)cc12 CHEMBL3668455 IC50 30.0 nM
COc1ccc(F)cc1-c1ccnc2[nH]c(C3=CCN(S(N)(=O)=O)CC3)cc12 CHEMBL3668486 IC50 30.0 nM
CC(=O)N1CCC(c2cc3c(-c4cncc(NCc5ccccc5)n4)ccnc3[nH]2)CC1 CHEMBL3673513 IC50 30.0 nM
CNC(=O)N1CC=C(c2[nH]c3nccc4c3c2CN(C)c2ccc(F)cc2-4)CC1 CHEMBL3938690 IC50 30.0 nM
CC[C@H]1c2c(C3=CCNCC3)[nH]c3nccc(c23)-c2cc(F)ccc2N1C CHEMBL3923572 IC50 30.0 nM
CN1Cc2c(C3=CCN[C@@H](CO)C3)[nH]c3nccc(c23)-c2cc(F)ccc21 CHEMBL3927462 IC50 30.0 nM
COc1cc(O)c2c(=O)cc(-c3ccc(N4CCN(C)CC4)cc3)oc2c1N1CCNCC1 CHEMBL5287796 IC50 30.0 nM
CC(C)C1CNC(=O)c2cc(-c3ccnc(N)n3)[nH]c21 CHEMBL445340 IC50 31.0 nM
COc1cccnc1-c1ccnc2[nH]c(C3CCNCC3)cc12 CHEMBL3663762 IC50 31.0 nM
COc1ccc(F)cc1-c1ccnc2[nH]c(C3CCN(C(=O)CN4CCC(O)CC4)CC3)cc12 CHEMBL3668419 IC50 31.0 nM
c1cc(-c2cncc(NCC3CCOCC3)n2)c2cc(C3CCNCC3)[nH]c2n1 CHEMBL3673502 IC50 31.0 nM
O=C(CO)N1CCC(c2cc3c(-c4cncc(NCc5cc(F)cc(F)c5)n4)ccnc3[nH]2)CC1 CHEMBL3673508 IC50 31.0 nM
O=C(O)c1ccccc1Nc1ccnc(Nc2cccc(F)c2)n1 CHEMBL243298 pKi 31.62 nM
NC1CCCCC1Nc1nccc(-c2c[nH]c3ncccc23)n1 CHEMBL1995813 pKi 31.62 nM
CC(C)(CNc1cc(-c2c[nH]c3ncccc23)cc(Cl)n1)CNS(C)(=O)=O CHEMBL1971172 pKi 31.62 nM
COc1ccccc1-c1ccnc(Nc2cccc(S(C)(=O)=O)c2)n1 CHEMBL1975903 pKi 31.62 nM
COc1ccc(-c2ccnc(Nc3ccc4c(c3)N(C(C)C)[C@H](C)C(=O)N4C)n2)cc1 CHEMBL4796617 IC50 31.7 nM
COc1ccc(F)cc1-c1ccnc2[nH]c(C3CCN(CC(N)=O)CC3)cc12 CHEMBL3668512 IC50 32.0 nM
Clc1ccc(NCc2ccccc2)nc1-c1ccnc2[nH]c(C3CCCNC3)cc12 CHEMBL3663753 IC50 33.0 nM
Fc1ccccc1CNc1ccc(Cl)c(-c2ccnc3[nH]c(C4CCNCC4)cc23)n1 CHEMBL3663779 IC50 33.0 nM
COc1ccc(F)cc1-c1ccnc2[nH]c(C3=CCN(C(C)=O)CC3)cc12 CHEMBL3668373 IC50 33.0 nM
c1ccc(CCNc2cccc(-c3ccnc4[nH]c(C5CCNCC5)cc34)n2)cc1 CHEMBL3668410 IC50 33.0 nM
COc1ccc(F)cc1-c1ccnc2[nH]c(C3CCCCNC3)cc12 CHEMBL3668464 IC50 33.0 nM
Fc1ccc(NCc2ccccc2)cc1-c1c(Cl)cnc2[nH]c(C3CCNCC3)cc12 CHEMBL3668465 IC50 33.0 nM
COc1ccc(F)cc1-c1ccnc2[nH]c(C3=CCN(CC(=O)O)CC3)cc12 CHEMBL3668495 IC50 33.0 nM
C=CC(=O)Nc1ccc(C(=O)N2CC[C@@H](Nc3ncc(SCc4ncc(C(C)(C)C)o4)s3)C2)cc1 CHEMBL4788136 IC50 33.0 nM
CN1CCC(c2cc3c(-c4cccc(NCC5CCOCC5)n4)ccnc3[nH]2)CC1 CHEMBL3668363 IC50 34.0 nM
CN1CCC(c2cc3c(-c4cccc(NCC5CC5)n4)ccnc3[nH]2)CC1 CHEMBL3668366 IC50 34.0 nM
CCOC(=O)C1CC1CN[C@H]1CC[C@H](c2cc3c(-c4cc(F)ccc4OC)ccnc3[nH]2)CC1 CHEMBL3668394 IC50 34.0 nM
COc1ccc(F)cc1-c1ccnc2[nH]c(C3CN(CCN)C3)cc12 CHEMBL3668440 IC50 34.0 nM
CN1Cc2c(C3=CCNCC3)[nH]c3ncc(F)c(c23)-c2ccccc21 CHEMBL3942903 IC50 34.0 nM
O=C(c1ccc(-c2ccnc3[nH]c(-c4ccc(CN5CCOCC5)cc4)nc23)cc1)N1CCCC1 CHEMBL5201044 IC50 34.0 nM
O=C1NCCc2[nH]c(-c3ccncc3)cc21 CHEMBL5275973 IC50 34.0 nM
CN1CCC(c2cc3c(-c4cccc(NCCCc5ccccc5)n4)ccnc3[nH]2)CC1 CHEMBL3974193 IC50 35.0 nM
COc1ccc(F)cc1-c1ccnc2[nH]c(C3CCCN(C)C3)cc12 CHEMBL3663751 IC50 35.0 nM
CN1CCC(c2cc3c(-c4nc(NCc5ccc(OCC(=O)O)cc5)ccc4Cl)ccnc3[nH]2)CC1 CHEMBL3668447 IC50 35.0 nM
CNC(=O)N1CCC(c2cc3c(-c4cncc(NCc5ccccc5)n4)ccnc3[nH]2)CC1 CHEMBL3673525 IC50 35.0 nM
C1=C/COCc2cc(ccc2OCCN2CCCC2)Nc2nccc(n2)-c2ccc(o2)COC/1 CHEMBL2035185 IC50 36.0 nM
COc1ccc(F)cc1-c1ccnc2[nH]c(C3=CCN(C(=O)CO)CC3)cc12 CHEMBL3668374 IC50 36.0 nM
c1ccc(SCCNc2cccc(-c3ccnc4[nH]c(C5CCNCC5)cc34)n2)cc1 CHEMBL3668380 IC50 36.0 nM
COc1ccc(F)cc1-c1ccnc2[nH]c(C3CCN(CC4CCCOC4)C3)cc12 CHEMBL3668387 IC50 36.0 nM
c1cc(CNc2cncc(-c3ccnc4[nH]c(C5CCNCC5)cc34)n2)ccn1 CHEMBL3673506 IC50 36.0 nM
CN1Cc2c(C3=CCN(S(C)(=O)=O)CC3)[nH]c3nccc(c23)-c2cc(F)c(F)cc21 CHEMBL3973391 IC50 36.0 nM
CC(=O)N[C@@H]1CCC[C@H](C(=O)Nc2cc(-c3cnc4n3CC(C)(C)C4)c(Cl)cn2)C1 CHEMBL4749175 IC50 36.0 nM
CC(=O)N[C@@H]1CCC[C@H](C(=O)Nc2cc(-c3cnn4c3CC(C)C4)c(Cl)cn2)C1 CHEMBL4753256 IC50 36.0 nM
CC(=O)N1CCC(n2cc(Nc3ncc(Cl)c(-c4cnc5ccccn45)n3)cn2)CC1 CHEMBL3823659 IC50 37.0 nM
COc1ccc(F)cc1-c1ccnc2[nH]c(C3CNCCO3)cc12 CHEMBL3663807 IC50 37.0 nM
COc1ccc(F)cc1-c1ccnc2[nH]c(C3=CCN(S(C)(=O)=O)CC3)cc12 CHEMBL3668392 IC50 37.0 nM
COc1ccc(F)cc1-c1ccnc2[nH]c(C3=CCN(C(=O)Nc4cnn(C)c4)CC3)cc12 CHEMBL3668494 IC50 37.0 nM
CN1Cc2c(C3=C[C@@H]4COC(=O)N4CC3)[nH]c3nccc(c23)-c2cc(F)ccc21 CHEMBL3924439 IC50 37.0 nM
CCNc1cccc(-c2ccnc(Nc3ccc4c(c3)N(C(C)C)[C@H](C)C(=O)N4C)n2)c1 CHEMBL4786023 IC50 37.8 nM
COc1ccc(F)cc1-c1ccnc2[nH]c(C3=CC4CCC(C3)N4S(C)(=O)=O)cc12 CHEMBL3965720 IC50 38.0 nM
COc1ccc(F)cc1-c1ccnc2[nH]c(C3CCN(Cc4ccccn4)C3)cc12 CHEMBL3668384 IC50 38.0 nM
COc1ccc(F)cc1-c1ccnc2[nH]c(C3CCN(CC(=O)N(C)C)CC3)cc12 CHEMBL3668502 IC50 38.0 nM
CN(CC(O)CO)C(=O)CN1CC=C(c2[nH]c3nccc4c3c2CN(C)c2ccc(F)cc2-4)CC1 CHEMBL3900836 IC50 38.0 nM
CN1Cc2c(C3=CCN(S(C)(=O)=O)CC3)[nH]c3ncc(F)c(c23)-c2cc(F)ccc21 CHEMBL3946855 IC50 38.0 nM
CC1(C)Cc2c(-c3cc(NC(=O)[C@H]4C[C@@H](O)C4)ncc3Cl)cnn2C1 CHEMBL4740254 EC50 38.0 nM
Clc1cnc2[nH]c(C3CCCNC3)cc2c1-c1cccc(NCc2ccccc2)n1 CHEMBL3668354 IC50 39.0 nM
COc1ccc(F)cc1-c1ccnc2[nH]c(C3CCN(CCN)C3)cc12 CHEMBL3668396 IC50 39.0 nM
COc1cc(C#N)ccc1-c1ccnc2[nH]c(C3CCCNC3)cc12 CHEMBL3668409 IC50 39.0 nM
COc1ccc(F)cc1-c1ccnc2[nH]c(C3=CCN(CC(=O)N(C)C)CC3)cc12 CHEMBL3668493 IC50 39.0 nM
CNC(=O)CN1CCC(c2cc3c(-c4cc(F)ccc4OC)ccnc3[nH]2)CC1 CHEMBL3668513 IC50 39.0 nM
CC(=O)N[C@@H]1CCC[C@H](C(=O)Nc2cc(-c3cnn4c3CC(C)(C)CC4)ccn2)C1 CHEMBL4785242 EC50 39.0 nM
CC(=O)N1CCC(c2cc3c(-c4ccc(=O)n(C(C)C)c4)ccnc3[nH]2)CC1 CHEMBL5181511 IC50 39.0 nM
CC(C)N1c2cc(Nc3nccc(-c4ccccc4N)n3)ccc2N(C)C(=O)[C@H]1C CHEMBL4760844 IC50 39.2 nM
NC(=O)c1ccccc1Nc1nc(Nc2ccccc2)ncc1C(F)(F)F CHEMBL1997554 pKi 39.81 nM
O=C(O)c1ccccc1Nc1ccnc(Nc2ccc3[nH]ncc3c2)n1 CHEMBL396523 pKi 39.81 nM
NC(=O)c1ccc2nc(-c3ccc([N+](=O)[O-])o3)cn2c1 CHEMBL1973359 pKi 39.81 nM
CCCC(=O)Nc1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12 CHEMBL1977223 pKi 39.81 nM
COc1ccc(F)cc1-c1ccnc2[nH]c(C3CCN(CCN4CCOCC4)CC3)cc12 CHEMBL3949793 IC50 40.0 nM
O=C(CO)N1CCC(c2cc3c(-c4cncc(NCc5ccccc5)n4)ccnc3[nH]2)CC1 CHEMBL3673510 IC50 40.0 nM
CN1Cc2c(C3=CCN(CC(=O)N(C)C4CC(O)C4)CC3)[nH]c3nccc(c23)-c2cc(F)ccc21 CHEMBL3938400 IC50 40.0 nM
CN(C)C(=O)CN1CC=C(c2[nH]c3nccc4c3c2CN(C)c2cc(F)c(F)cc2-4)CC1 CHEMBL3931677 IC50 40.0 nM
CN1Cc2c(C3=CCN(S(C)(=O)=O)CC3)[nH]c3ncc(F)c(c23)-c2ccccc21 CHEMBL3929697 IC50 40.0 nM
CC(=O)N[C@@H]1CCC[C@H](C(=O)Nc2cc(-c3cnn4c3CC(C)(C)C4)c(C)cn2)C1 CHEMBL4753076 IC50 40.0 nM
CN1CCC(c2cc3c(-c4nc(NCc5ccc(S(C)(=O)=O)cc5)ccc4Cl)ccnc3[nH]2)CC1 CHEMBL3668431 IC50 41.0 nM
CN1CCC(c2cc3c(-c4cncc(NCc5cccnc5)n4)ccnc3[nH]2)CC1 CHEMBL3673534 IC50 41.0 nM
CNC(=O)N1CC2C=C(c3[nH]c4nccc5c4c3CN(C)c3ccc(F)cc3-5)CC2C1 CHEMBL3982622 IC50 41.0 nM
CN1Cc2c(C3=C[C@H]4COC(=O)N4CC3)[nH]c3nccc(c23)-c2cc(F)ccc21 CHEMBL3905946 IC50 41.0 nM
CN1Cc2c(C3=C[C@@H](CO)NCC3)[nH]c3nccc(c23)-c2cc(F)ccc21 CHEMBL3928730 IC50 41.0 nM
Nc1cc(-c2ccc3occc3c2)cc(N)n1 CHEMBL5092362 IC50 41.0 nM
COc1cc(F)ccc1-c1ccnc2[nH]c(C3CNCCO3)cc12 CHEMBL3663806 IC50 42.0 nM
COc1ccc(F)cc1-c1c(F)cnc2[nH]c(C3=CCN(CC(=O)N4CC(O)C4)CC3)cc12 CHEMBL3668559 IC50 42.0 nM
CN1Cc2c(C3=CCN(C4CC(CC(=O)O)C4)CC3)[nH]c3nccc(c23)-c2cc(F)ccc21 CHEMBL3923934 IC50 42.0 nM
CN1Cc2c(C3=CCN(CC(=O)O)CC3)[nH]c3nccc(c23)-c2cc(F)c(F)cc21 CHEMBL3937675 IC50 42.0 nM
COc1ccc(F)cc1-c1ccnc2[nH]c(C3CCN(CCN4CCOCC4)C3)cc12 CHEMBL3668391 IC50 43.0 nM
Clc1ccc(NCc2cccnc2)nc1-c1ccnc2[nH]c(C3CCCNC3)cc12 CHEMBL3668478 IC50 43.0 nM
OCC(O)CN1CCC(c2cc3c(-c4cncc(NCc5cccnc5)n4)ccnc3[nH]2)CC1 CHEMBL3673535 IC50 43.0 nM
CN(CCO)C(=O)CN1CC2C=C(c3[nH]c4nccc5c4c3CN(C)c3ccc(F)cc3-5)CC2C1 CHEMBL3959305 IC50 43.0 nM
CN1Cc2c(C3=CCN(CC(=O)N(C)C4CC(O)C4)CC3)[nH]c3ncc(F)c(c23)-c2cc(F)ccc21 CHEMBL3912612 IC50 43.0 nM
C[C@H](Nc1cccc(-c2ccnc3[nH]c(C4CCN(C)CC4)cc23)n1)c1ccccc1 CHEMBL3668377 IC50 44.0 nM
COc1ccc(F)cc1-c1ccnc2[nH]c(C3CCN(CCO)C3)cc12 CHEMBL3668382 IC50 44.0 nM
COc1ccc(F)cc1-c1ccnc2[nH]c(C3CCN(C4CCOCC4)C3)cc12 CHEMBL3668383 IC50 44.0 nM
COc1ccc(F)cc1-c1ccnc2[nH]c(C3CCN(C(C)=O)CC3)cc12 CHEMBL3668407 IC50 44.0 nM
O=C(O)C1CC=C(c2cc3c(-c4cncc(NCc5cccc(F)c5)n4)ccnc3[nH]2)CC1 CHEMBL3673548 IC50 44.0 nM
NC(=O)C1CC=C(c2cc3c(-c4cncc(NCc5cccc(F)c5)n4)ccnc3[nH]2)CC1 CHEMBL3673552 IC50 44.0 nM
CN1Cc2c(C3=CCN(CC(=O)N4CC(O)C4)CC3)[nH]c3nccc(c23)-c2cc(F)ccc21 CHEMBL3985050 IC50 44.0 nM
CN(C)C(=O)CN1CC=C(c2[nH]c3ncc(F)c4c3c2CN(C)c2ccc(F)cc2-4)CC1 CHEMBL3952162 IC50 44.0 nM
CN1Cc2c(C3=CC4CCCC(C3)N4C(=O)CC#N)[nH]c3nccc(c23)-c2cc(F)ccc21 CHEMBL3903886 IC50 44.0 nM
CN1CCC(c2cc3c(-c4nc(NCc5ccc(S(N)(=O)=O)cc5)ccc4Cl)ccnc3[nH]2)CC1 CHEMBL3668432 IC50 45.0 nM
COc1ccc(F)cc1-c1c(F)cnc2[nH]c(C3=CCN(CC(=O)N(C)C)CC3)cc12 CHEMBL3668499 IC50 45.0 nM
COc1ccc(F)cc1-c1ccnc2[nH]c(C3CCN(CC(=O)N4CCC[C@H]4CO)CC3)cc12 CHEMBL3668514 IC50 45.0 nM
COc1ccc(F)cc1-c1ccnc2[nH]c(C3CCN(CC(=O)NC4CC(O)C4)CC3)cc12 CHEMBL3639673 IC50 45.0 nM
COc1ccc(F)cc1-c1ccnc2[nH]c(C3=CCN(CC(=O)N(C)C)CC3)c(C#N)c12 CHEMBL3668522 IC50 45.0 nM
CNC(=O)N1CCC(c2cc3c(-c4cncc(OCc5cccc(F)c5)n4)ccnc3[nH]2)CC1 CHEMBL3673529 IC50 45.0 nM
CN(CC(O)CO)C(=O)CN1CC=C(c2[nH]c3ncc(F)c4c3c2CN(C)c2ccc(F)cc2-4)CC1 CHEMBL3911547 IC50 45.0 nM
CN1Cc2c(C3=CCN(CC(=O)N4CCC[C@H]4CO)CC3)[nH]c3nccc(c23)-c2cc(F)c(F)cc21 CHEMBL3946513 IC50 45.0 nM
CN1Cc2c(C3=CCN(C4CCC(=CC#N)CC4)CC3)[nH]c3nccc(c23)-c2cc(F)ccc21 CHEMBL3920906 IC50 45.0 nM
COc1cc(F)ccc1-c1ccnc2[nH]c(C3CCN(CCO)CC3)cc12 CHEMBL5180640 IC50 45.0 nM
COc1ccc(F)cc1-c1ccnc2[nH]c(C3CCN(C4CCNC4)C3)cc12 CHEMBL3668397 IC50 46.0 nM
CN1CCC(c2cc3c(-c4nc(NCc5cccc(S(C)(=O)=O)c5)ccc4Cl)ccnc3[nH]2)CC1 CHEMBL3668459 IC50 46.0 nM
CC(C)[C@@H](NC1CC=C(c2[nH]c3nccc4c3c2CN(C)c2ccc(F)cc2-4)CC1)C(=O)O CHEMBL3981309 IC50 46.0 nM
CN1Cc2c(C3=C[C@H]4CC[C@@H](C3)N4)[nH]c3nccc(c23)-c2cc(F)ccc21 CHEMBL3975203 IC50 46.0 nM
CN(C)C(=O)CN1CC2C=C(c3[nH]c4nccc5c4c3CN(C)c3ccc(F)cc3-5)CC2C1 CHEMBL3953940 IC50 46.0 nM
CN1Cc2c(C3=CCCNC3)[nH]c3nccc(c23)-c2cc(F)ccc21 CHEMBL3934364 IC50 46.0 nM
CN(CCO)C(=O)CN1CC=C(c2[nH]c3nccc4c3c2CN(C)c2cc(F)c(F)cc2-4)CC1 CHEMBL3951656 IC50 46.0 nM
COc1cc(F)ccc1-c1ccnc(Nc2ccc3c(c2)N(C(C)C)[C@H](C)C(=O)N3C)n1 CHEMBL4793212 IC50 46.9 nM
CN(C)CCOc1ccc(CNc2cccc(-c3ccnc4[nH]c(C5CCN(C)CC5)cc34)n2)cc1 CHEMBL3668424 IC50 47.0 nM
CN(C)C(=O)CN1CC=C(c2cc3c(-c4cccc(F)c4F)ccnc3[nH]2)CC1 CHEMBL3668501 IC50 47.0 nM
CCN(C(=O)O)S(=O)(=O)NC1CC=C(c2cc3c(-c4cc(F)ccc4OC)ccnc3[nH]2)CC1 CHEMBL3668517 IC50 47.0 nM
CCOC(=O)NS(=O)(=O)N1CC=C(c2[nH]c3nccc4c3c2CN(C)c2ccc(F)cc2-4)CC1 CHEMBL3984563 IC50 47.0 nM
COC(=O)CC1CCC(N2CC=C(c3[nH]c4nccc5c4c3CN(C)c3cc(F)c(F)cc3-5)CC2)CC1 CHEMBL3944130 IC50 47.0 nM
COc1cc(F)ccc1-c1ccnc2[nH]c(C3CCC(NC(C)=O)C3)nc12 CHEMBL5191333 IC50 47.0 nM
CCN(Cc1ccccc1)c1ccc(Cl)c(-c2ccnc3[nH]c(C4CCNCC4)cc23)n1 CHEMBL3663787 IC50 48.0 nM
CCC1c2c(C3=CCNCC3)[nH]c3nccc(c23)-c2cc(F)ccc2N1C CHEMBL3976491 IC50 48.0 nM
CN(CCO)C(=O)CN1CC=C(c2[nH]c3nccc4c3c2CN(C)c2ccc(F)cc2-4)CC1 CHEMBL3915267 IC50 48.0 nM
CN1Cc2c(C3=CCN(CC(=O)N4CC[C@H](O)C4)CC3)[nH]c3nccc(c23)-c2cc(F)ccc21 CHEMBL3971127 IC50 48.0 nM
CN1Cc2c(C3=CCN(CC(=O)O)CC3)[nH]c3ncc(F)c(c23)-c2cc(F)ccc21 CHEMBL3984185 IC50 48.0 nM
CN1Cc2c(C3=CCN([C@H]4CC[C@@H](CC(=O)O)CC4)CC3)[nH]c3nccc(c23)-c2cc(F)ccc21 CHEMBL3958069 IC50 48.0 nM
CC(C)N1c2cc(Nc3nccc(-c4ccc(N)cc4)n3)ccc2N(C)C(=O)[C@H]1C CHEMBL4740586 IC50 48.9 nM
COc1cc(F)ccc1-c1ccnc2[nH]c(C3CCCN(C)C3)cc12 CHEMBL3663750 IC50 49.0 nM
Fc1ccc(NCc2ccccc2)cc1-c1ccnc2[nH]c(C3CCNCC3)cc12 CHEMBL3663791 IC50 49.0 nM
C[C@H](Nc1ccc(Cl)c(-c2ccnc3[nH]c(C4CCNCC4)cc23)n1)c1ccccc1 CHEMBL3663795 IC50 49.0 nM
CN1CCC(c2cc3c(-c4cccc(NCc5ccc6c(c5)CNC6)n4)ccnc3[nH]2)CC1 CHEMBL3668428 IC50 49.0 nM
COc1ccc(F)cc1-c1c(F)cnc2[nH]c(C3=CCN(S(C)(=O)=O)CC3)c(C#N)c12 CHEMBL3668530 IC50 49.0 nM
CC(=O)NC1CCCC(C(=O)Nc2cc(-c3cnn4c3CC(C)(C)C4)c(Cl)cn2)C1 CHEMBL4759074 IC50 49.0 nM
CN1CCC(c2cc3c(-c4cccc(N(C)Cc5ccccc5)n4)ccnc3[nH]2)CC1 CHEMBL3668369 IC50 50.0 nM
COCCN1CCCC(c2cc3c(-c4cc(F)ccc4OC)ccnc3[nH]2)C1 CHEMBL3668402 IC50 50.0 nM
CCCc1cc(N[C@@H]2CC[C@@H](N)C2)n2nccc2n1 CHEMBL5285499 IC50 50.0 nM
O=c1cc(-c2ccncc2)nc(NC2CCCCC2)[nH]1 CHEMBL1958401 pKi 50.12 nM
CS(=O)(=O)NC1CCCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)C1 CHEMBL1987948 pKi 50.12 nM
CCC(=O)Nc1ccc(C(=O)N2CCNCC2)c(O)c1 CHEMBL1988141 pKi 50.12 nM
CC(C)Nc1cccc(-c2ccnc(Nc3ccc4c(c3)N(C(C)C)[C@H](C)C(=O)N4C)n2)c1 CHEMBL4745398 IC50 50.9 nM
CN1CCC(c2cc3c(-c4cccc(NCCSc5ccccc5)n4)ccnc3[nH]2)CC1 CHEMBL3668365 IC50 51.0 nM
CN1CCC(c2cc3c(-c4nc(NCc5ccncc5)ccc4Cl)ccnc3[nH]2)CC1 CHEMBL3668426 IC50 51.0 nM
CN(C)C(=O)CN1CC=C(c2[nH]c3nccc4c3c2CN(C)c2ccc(F)cc2-4)CC1 CHEMBL3914190 IC50 51.0 nM
CN1Cc2c(C3=CCN(CC(=O)N4CCC[C@@H]4CO)CC3)[nH]c3ncc(F)c(c23)-c2cc(F)ccc21 CHEMBL3981660 IC50 51.0 nM
CN1Cc2c(C3=CCN([C@H]4CC[C@H](C(=O)O)CC4)CC3)[nH]c3nccc(c23)-c2cc(F)ccc21 CHEMBL3951638 IC50 51.0 nM
CN1CCC(c2cc3c(-c4cc(NCC5CCOCC5)ccc4F)ccnc3[nH]2)CC1 CHEMBL3668450 IC50 52.0 nM
CN1Cc2c(C3=CCN(CC(=O)N4CC[C@H](O)C4)CC3)[nH]c3ncc(F)c(c23)-c2cc(F)ccc21 CHEMBL3970274 IC50 52.0 nM
CN1Cc2c(C3=CCN(CC(=O)N4CC(O)C4)CC3)[nH]c3nccc(c23)-c2cc(F)c(F)cc21 CHEMBL3945173 IC50 52.0 nM
CS(=O)(=O)N1CC=C(c2cc3c(-c4cccc(F)c4F)ccnc3[nH]2)CC1 CHEMBL3668490 IC50 53.0 nM
COc1ccc(F)cc1-c1ccnc2[nH]c(C3=CCN(CC(=O)N4CCC[C@H]4CO)CC3)cc12 CHEMBL3668506 IC50 53.0 nM
CN1Cc2c(C3=CCN(CC(=O)N(C)C4CC(O)C4)CC3)[nH]c3nccc(c23)-c2cc(F)c(F)cc21 CHEMBL3983849 IC50 53.0 nM
CN1Cc2c(C3=C[C@@H]4COC(=O)N4CC3)[nH]c3nccc(c23)-c2cc(F)c(F)cc21 CHEMBL3930577 IC50 54.0 nM
CN(C)C/C=C/C(=O)Nc1ccc(C(=O)N2CC[C@@H](Nc3ncc(SCc4ncc(C(C)(C)C)o4)s3)C2)cc1 CHEMBL4758168 IC50 54.5 nM
CC(=O)N1CCC(CNc2ccc(Cl)c(-c3ccnc4[nH]c(C5CCN(C)CC5)cc34)n2)CC1 CHEMBL3668448 IC50 55.0 nM
CN(Cc1ccccc1)c1ccc(Cl)c(-c2ccnc3[nH]c(C4CCCNC4)cc23)n1 CHEMBL3668470 IC50 55.0 nM
COc1ccc(F)cc1-c1ccnc2[nH]c(C3=CCN(Cc4ccc(NC(C)=O)cc4)CC3)cc12 CHEMBL3668487 IC50 56.0 nM
COc1ccc(F)cc1-c1ccnc2[nH]c(C3=CCN(C(=O)[C@H]4C[C@@H](O)CN4)CC3)cc12 CHEMBL3668507 IC50 56.0 nM
COc1ccc(F)cc1-c1ccnc2[nH]c(C3CCN(CC(=O)N(C)CCO)CC3)cc12 CHEMBL3668518 IC50 56.0 nM
CN1Cc2c(C3=CCC(N[C@H](C(=O)O)c4ccccc4)CC3)[nH]c3nccc(c23)-c2cc(F)ccc21 CHEMBL3976947 IC50 56.0 nM
CN(C)C(=O)CN1CC=C(c2[nH]c3ncc(F)c4c3c2CN(C)c2ccccc2-4)CC1 CHEMBL3908787 IC50 56.0 nM
COc1ccc(F)cc1-c1ccnc2[nH]c(C3=CCN([C@H]4CC[C@H](CC(=O)O)CC4)CC3)cc12 CHEMBL3668554 IC50 57.0 nM
CN1Cc2c(C3=CCN(CC(=O)N(CCO)CCO)CC3)[nH]c3nccc(c23)-c2cc(F)ccc21 CHEMBL3942947 IC50 57.0 nM
CN1Cc2c(C3=CC4CCCC(C3)N4CC(=O)N3CCC[C@H]3CO)[nH]c3nccc(c23)-c2cc(F)ccc21 CHEMBL3969304 IC50 57.0 nM
CN1Cc2c(C3=CCN([C@H]4CC[C@H](C(=O)O)CC4)CC3)[nH]c3nccc(c23)-c2cc(F)c(F)cc21 CHEMBL3952127 IC50 57.0 nM
COC(=O)C(C)=C1CCC(N2CC=C(c3[nH]c4nccc5c4c3CN(C)c3ccc(F)cc3-5)CC2)CC1 CHEMBL3898302 IC50 57.0 nM
CCN1CCN(Cc2ccc(Nc3ncc(F)c(-c4cc(F)c5nc(C)n(C(C)C)c5c4)n3)nc2)CC1 CHEMBL3301610 IC50 57.0 nM
COc1cc(F)ccc1-c1ccnc2[nH]c(C3CCNCC3)nc12 CHEMBL5192139 IC50 57.0 nM
COc1cc(C(=O)N2CCCC2)ccc1-c1ccnc2[nH]c(C3CCOCC3)cc12 CHEMBL5199352 IC50 57.0 nM
CN1Cc2c(C3=C[C@H](CO)NCC3)[nH]c3nccc(c23)-c2cc(F)c(F)cc21 CHEMBL3982368 IC50 58.0 nM
CN1Cc2c(C3=CCN([C@H]4CC[C@@H](CC(=O)O)CC4)CC3)[nH]c3nccc(c23)-c2cc(F)c(F)cc21 CHEMBL3917273 IC50 58.0 nM
CN1Cc2c(C3=CCN(C4CCC(=CC(=O)O)CC4)CC3)[nH]c3nccc(c23)-c2cc(F)ccc21 CHEMBL3907184 IC50 58.0 nM
CC[C@H](Nc1nc(NCc2cccc(Cl)c2)c2ncn(C(C)C)c2n1)[C@@H](C)O CHEMBL3655764 IC50 60.0 nM
[O-][n+]1cccc(CNc2ccc(Cl)c(-c3ccnc4[nH]c(C5CCNCC5)cc34)n2)c1 CHEMBL3919070 IC50 60.0 nM
CS(=O)(=O)N1CCC(c2cc3c(-c4cncc(OCc5cccc(F)c5)n4)ccnc3[nH]2)CC1 CHEMBL3673527 IC50 60.0 nM
CC[C@H]1c2c(C3=CCN(CC(=O)N(C)C)CC3)[nH]c3nccc(c23)-c2cc(F)ccc2N1C CHEMBL3937985 IC50 60.0 nM
COc1ccc(F)cc1-c1ccnc2[nH]c(C3=CC4CCC(C3)N4C(=O)Cn3c(OC)cc4cccnc43)cc12 CHEMBL3930674 IC50 61.0 nM
COc1ccc(F)cc1-c1ccnc2[nH]c(C3CCN(CC4CCOCC4)C3)cc12 CHEMBL3668390 IC50 61.0 nM
CN1Cc2c(C3=CCN(CC(=O)O)CC3)[nH]c3nccc(c23)-c2cc(F)ccc21 CHEMBL3892764 IC50 61.0 nM
CN1Cc2c(C3=CCC(N[C@@H](Cc4ccccc4)C(=O)O)CC3)[nH]c3nccc(c23)-c2cc(F)ccc21 CHEMBL3953020 IC50 61.0 nM
COc1ccc(F)cc1-c1ccnc2[nH]c(C3=CCC(C(=O)O)CC3)cc12 CHEMBL3668489 IC50 62.0 nM
COc1ccc(F)cc1-c1ccnc2[nH]c(C3=CCN(CC(=O)N4CC(O)C4)CC3)cc12 CHEMBL3668505 IC50 62.0 nM
CS(=O)(=O)N1CC=C(c2[nH]c3nccc4c3c2CNc2ccc(F)cc2-4)CC1 CHEMBL3899222 IC50 62.0 nM
CN1Cc2c(C3=CCN(CC(=O)N4CCC[C@@H]4CO)CC3)[nH]c3nccc(c23)-c2cc(F)ccc21 CHEMBL3960860 IC50 62.0 nM
CN1Cc2c(C3=CC4CN(S(C)(=O)=O)CC4C3)[nH]c3nccc(c23)-c2cc(F)ccc21 CHEMBL3914697 IC50 62.0 nM
COc1ccc(F)cc1-c1ccnc2[nH]c(C3CNC(C)(C)CO3)cc12 CHEMBL3668345 IC50 63.0 nM
Fc1cccc(-c2c(Cl)cnc3[nH]c(C4CCCNC4)cc23)c1 CHEMBL3668352 IC50 63.0 nM
CNC(=O)C1CC=C(c2[nH]c3nccc4c3c2CN(C)c2ccc(F)cc2-4)CC1 CHEMBL3975721 IC50 63.0 nM
CN1Cc2c(C3=CCN(CC(=O)N4CC(F)(F)C4)CC3)[nH]c3nccc(c23)-c2cc(F)ccc21 CHEMBL3967245 IC50 63.0 nM
CN1Cc2c(C3=CCNCC3)[nH]c3nccc(c23)-c2cccnc21 CHEMBL3970239 IC50 63.0 nM
CN1Cc2c(C3=CCN([C@H]4CC[C@H](C(=O)O)CC4)CC3)[nH]c3ncc(F)c(c23)-c2ccccc21 CHEMBL3982885 IC50 63.0 nM
COc1ccc(F)cc1-c1ccnc2[nH]c(C3=CCC(NCC(=O)O)CC3)cc12 CHEMBL4872494 IC50 63.0 nM
CN(c1ncccc1CNc1nc(Nc2ccc3c(c2)CC(=O)N3)ncc1C(F)(F)F)S(C)(=O)=O CHEMBL1084546 pKi 63.1 nM
NC1CCC(Nc2cc(Cl)nc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1983589 pKi 63.1 nM
CS(=O)(=O)NCCNc1cc(-c2c[nH]c3ncccc23)cc(Cl)n1 CHEMBL2005718 pKi 63.1 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4cccc(Cl)c4)c3)cc12 CHEMBL1974870 pKi 63.1 nM
CN1CCN(c2ccc(Nc3nc(N)c(C(=O)c4c(Cl)cccc4Cl)s3)cc2)CC1 CHEMBL1989043 pKi 63.1 nM
Cc1ccc(Nc2nc3ccc([N+](=O)[O-])cc3[nH]2)nc1 CHEMBL1992937 pKi 63.1 nM
CNc1nc(C)c(-c2ccnc(Nc3ccc(N4CCNCC4)cc3)n2)s1 CHEMBL1999484 pKi 63.1 nM
COc1ccc(F)cc1-c1ccnc2[nH]c([C@H]3CC[C@H](NCCCC(=O)O)CC3)cc12 CHEMBL3668403 IC50 64.0 nM
COc1ccc(F)cc1-c1ccnc2[nH]c(C3=CCN(S(=O)(=O)N(C(=O)O)C(C)(C)C)CC3)cc12 CHEMBL3668488 IC50 64.0 nM
CN1Cc2c(C3=CCC(N[C@H](C(=O)O)C(C)(C)C)CC3)[nH]c3nccc(c23)-c2cc(F)ccc21 CHEMBL3932928 IC50 64.0 nM
CN1Cc2c(C3=CCN([C@H]4CC[C@H](CC(=O)O)CC4)CC3)[nH]c3nccc(c23)-c2cc(F)ccc21 CHEMBL3976427 IC50 64.0 nM
CC[C@H]1c2c(C3=CCN([C@H]4C[C@@H](C(=O)OC)C4)CC3)[nH]c3nccc(c23)-c2cc(F)ccc2N1C CHEMBL3976415 IC50 64.0 nM
COc1ccc(F)cc1-c1ccnc2[nH]c(C3=CCN([C@H]4CC[C@@H](C(=O)O)CC4)CC3)cc12 CHEMBL4861217 IC50 64.0 nM
Clc1ccc(NCc2ccccc2)nc1-c1ccnc2[nH]c(C3CNCCO3)cc12 CHEMBL3668344 IC50 65.0 nM
CN(C)C/C=C/C(=O)Nc1ccc(C(=O)N2CCCC(Nc3ncc(SCc4ncc(C(C)(C)C)o4)s3)C2)cc1 CHEMBL4761001 IC50 65.0 nM
Fc1ccccc1CNc1ccc(Cl)c(-c2ccnc3[nH]c(C4CCCNC4)cc23)n1 CHEMBL3668477 IC50 66.0 nM
COc1ccc(F)cc1-c1ccnc2[nH]c(C3CCN(CC(=O)N(C)C4CC(O)C4)CC3)cc12 CHEMBL3668541 IC50 66.0 nM
CNC(=O)N1CCC(c2cc3c(-c4cncc(NCc5cccnc5)n4)ccnc3[nH]2)CC1 CHEMBL3673537 IC50 66.0 nM
CN1Cc2c(-c3ccc(S(C)(=O)=O)cc3)[nH]c3nccc(c23)-c2cc(F)ccc21 CHEMBL3899955 IC50 66.0 nM
CN1Cc2c(C3=CC4CCCC(C3)N4CC(=O)N(C)C3CC(O)C3)[nH]c3nccc(c23)-c2cc(F)ccc21 CHEMBL3897049 IC50 66.0 nM
CN1Cc2c(C3=CCN4C(=O)OC[C@H]4C3)[nH]c3nccc(c23)-c2cc(F)ccc21 CHEMBL3937521 IC50 66.0 nM
C=CC(=O)Nc1ccc(O[C@@H]2CCC[C@@H](Nc3ncc(SCc4ncc(C(C)(C)C)o4)s3)C2)cc1 CHEMBL4788401 IC50 66.5 nM
Nc1ccc(F)c(-c2ccnc3[nH]c(C4CCNCC4)cc23)c1 CHEMBL3668458 IC50 67.0 nM
CN(C)C(=O)CN1CC=C(c2[nH]c3nccc4c3c2CCN(C)c2ccc(F)cc2-4)CC1 CHEMBL3944945 IC50 67.0 nM
CN1Cc2c(C3=CCN([C@H]4CC[C@H](CC(=O)O)CC4)CC3)[nH]c3ncc(F)c(c23)-c2cc(F)ccc21 CHEMBL3915400 IC50 67.0 nM
CC(C)N1c2cc(Nc3nccc(-c4cccc5c4CCCN5)n3)ccc2N(C)C(=O)[C@H]1C CHEMBL4758996 IC50 67.0 nM
COc1ccc(C)cc1-c1ccnc2[nH]c(C3CCNCC3)cc12 CHEMBL3663766 IC50 68.0 nM
CN1Cc2c(-c3ccc(CC(=O)O)cc3)[nH]c3nccc(c23)-c2cc(F)ccc21 CHEMBL3977523 IC50 68.0 nM
CN1CCC(c2cc3c(-c4cccc(N(C)Cc5ccccc5Cl)n4)ccnc3[nH]2)CC1 CHEMBL3668414 IC50 69.0 nM
CN1Cc2c(C3=CCN(S(C)(=O)=O)CC3)[nH]c3nccc(c23)-c2cccnc21 CHEMBL3922725 IC50 69.0 nM
COc1ccc(F)cc1-c1ccnc2[nH]c(C3C[C@@H]4CN(S(C)(=O)=O)C[C@@H]4C3)cc12 CHEMBL3924904 IC50 70.0 nM
COc1ccc(F)cc1-c1ccnc2[nH]c(C3=CCC(N4CCC[C@H]4C(=O)O)CC3)cc12 CHEMBL3668509 IC50 70.0 nM
COc1ccc(F)cc1-c1c(F)cnc2[nH]c(C3=CC4CN(CC(=O)N5CC(O)C5)CC4C3)cc12 CHEMBL3668558 IC50 70.0 nM
CN1Cc2c(C3=CCN(CC(=O)N4CCC[C@H]4CO)CC3)[nH]c3nccc(c23)-c2cc(F)ccc21 CHEMBL3924254 IC50 70.0 nM
CN(C)C(=O)CN1CCC(c2cc3c(-c4ccc(=O)n(C5CCC5)c4)ccnc3[nH]2)CC1 CHEMBL5169733 IC50 70.0 nM
COc1ccc(F)cc1-c1ccnc2[nH]c(C3=CC4CN(C(=O)CO)CC4C3)cc12 CHEMBL3668545 IC50 71.0 nM
CNC(=O)N1C[C@@H]2CC(c3cc4c(-c5cc(F)ccc5OC)ccnc4[nH]3)=C[C@@H]2C1 CHEMBL3668549 IC50 71.0 nM
COc1ccc(F)cc1-c1ccnc2[nH]c(C3=CCN([C@H]4CC[C@@H](CC(=O)O)CC4)CC3)cc12 CHEMBL3668553 IC50 71.0 nM
CN1Cc2c(C3=CCN([C@H]4CC[C@@H](CC(=O)O)CC4)CC3)[nH]c3ncc(F)c(c23)-c2ccccc21 CHEMBL3892177 IC50 71.0 nM
CN1Cc2c(C3=C[C@H]4CC[C@@H](C3)N4CC(=O)N3CCC[C@H]3CO)[nH]c3nccc(c23)-c2cc(F)ccc21 CHEMBL3959178 IC50 72.0 nM
COc1ccc(F)cc1-c1ccnc2[nH]c(C3CN(Cc4ccncc4)C3)cc12 CHEMBL3668438 IC50 73.0 nM
CN1Cc2c(C3=C[C@H]4CC[C@@H](C3)N4CC(=O)N(C)C3CC(O)C3)[nH]c3nccc(c23)-c2cc(F)ccc21 CHEMBL4113920 IC50 73.0 nM
CN1Cc2c(C3=CCN([C@H]4CC[C@H](CC(=O)O)CC4)CC3)[nH]c3ncc(F)c(c23)-c2ccccc21 CHEMBL3954215 IC50 73.0 nM
COc1ccc(F)cc1-c1ccnc2[nH]c(C3CCN(C(C)=O)C3)cc12 CHEMBL3668381 IC50 74.0 nM
COc1ccc(F)cc1-c1ccnc2[nH]c(C3(O)CCNCC3)cc12 CHEMBL3668398 IC50 75.0 nM
CN1CCC(c2cc3c(-c4nc(NCC5CCN(C(=O)OC(C)(C)C)C5)ccc4Cl)ccnc3[nH]2)CC1 CHEMBL3668444 IC50 75.0 nM
CN1Cc2c(-c3cccnc3)[nH]c3nccc(c23)-c2cc(F)ccc21 CHEMBL3958055 IC50 75.0 nM
CN1Cc2c(C3=CCN([C@H]4CC[C@H](C(=O)O)CC4)CC3)[nH]c3ncc(F)c(c23)-c2cc(F)ccc21 CHEMBL3918837 IC50 75.0 nM
COc1ccc(F)cc1-c1ccnc2[nH]c(C3=CCN(c4ccc(CC(=O)O)cc4)CC3)cc12 CHEMBL4857987 IC50 75.0 nM
COc1ccc(F)cc1-c1ccnc2[nH]c(C3CN(CCO)C3)cc12 CHEMBL3668443 IC50 76.0 nM
CN1Cc2c(C3=CCN(C4CC(C(=O)O)C4)CC3)[nH]c3ncc(F)c(c23)-c2cc(F)ccc21 CHEMBL3891658 IC50 76.0 nM
COc1ccc(Cl)cc1-c1ccnc2[nH]c(C3CCNCC3)cc12 CHEMBL3663765 IC50 77.0 nM
COc1ccc(F)nc1-c1ccnc2[nH]c(C3CCNCC3)cc12 CHEMBL3663767 IC50 77.0 nM
COc1ccc(F)cc1-c1ccnc2[nH]c(C3CCN(CC(=O)N4CC(O)C4)CC3)cc12 CHEMBL3668519 IC50 77.0 nM
COc1ccc(F)cc1-c1ccnc2[nH]c(C3=CC4CN(C(=O)CC#N)CC4C3)cc12 CHEMBL3668546 IC50 77.0 nM
CN1CCC(c2cc3c(-c4nc(NCc5nnc[nH]5)ccc4Cl)ccnc3[nH]2)CC1 CHEMBL3668449 IC50 78.0 nM
COCCS(=O)(=O)N1CC2C=C(c3cc4c(-c5cc(F)ccc5OC)ccnc4[nH]3)CC2C1 CHEMBL3668539 IC50 78.0 nM
COc1ccc(F)cc1-c1c(C#N)cnc2[nH]c(C3CCN(CC(=O)N4CCC[C@H]4CO)CC3)cc12 CHEMBL3668555 IC50 78.0 nM
CN1CCc2c(C3=CCN(S(C)(=O)=O)CC3)[nH]c3nccc(c23)-c2cc(F)ccc21 CHEMBL3974363 IC50 78.0 nM
CN1Cc2c(C3=CCN(CC(=O)N4CC(O)C4)CC3)[nH]c3ncc(F)c(c23)-c2cc(F)ccc21 CHEMBL3899072 IC50 79.0 nM
CN1Cc2c(C3=CCN(C4CC(CC(=O)O)C4)CC3)[nH]c3ncc(F)c(c23)-c2cc(F)ccc21 CHEMBL3966523 IC50 79.0 nM
O=C1Nc2cc(-c3ccc(O)cc3)ccc2C1=Cc1ccc[nH]1 CHEMBL1980329 pKi 79.43 nM
N#Cc1cccc(C(=O)Nc2n[nH]c3ccc(-c4cn(Cc5ccccc5)nn4)cc23)c1 CHEMBL1977128 pKi 79.43 nM
O=C(O)c1ccccc1Nc1ccnc(Nc2ccc([N+](=O)[O-])cc2)n1 CHEMBL242865 pKi 79.43 nM
NCCNc1cc(-c2c[nH]c3ncccc23)cc(Cl)n1 CHEMBL1972290 pKi 79.43 nM
NC1CCCCC1Nc1nc(Cl)cc(-c2c[nH]c3ncccc23)n1 CHEMBL1994438 pKi 79.43 nM
CC(C)N1c2cc(Nc3nccc(-c4cccc5cnccc45)n3)ccc2N(C)C(=O)[C@H]1C CHEMBL4756594 IC50 79.8 nM
CC[C@H](Nc1nc(NCc2cccc(F)c2)c2ncn(C(C)C)c2n1)[C@@H](C)O CHEMBL3655765 IC50 80.0 nM
Clc1ccc(OCc2cccnc2)nc1-c1ccnc2[nH]c(C3CCCNC3)cc12 CHEMBL3668479 IC50 80.0 nM
COc1ccc(F)cc1-c1ccnc2[nH]c(C3=CCC(N[C@@H](C(=O)O)C(C)C)CC3)cc12 CHEMBL3668508 IC50 80.0 nM
COCCS(=O)(=O)N1CC2C=C(c3[nH]c4nccc5c4c3CN(C)c3ccc(F)cc3-5)CC2C1 CHEMBL3976153 IC50 80.0 nM
CN1Cc2c(C3=CCN([C@H]4CC[C@@H](C(=O)O)CC4)CC3)[nH]c3ncc(F)c(c23)-c2ccccc21 CHEMBL3961156 IC50 80.0 nM
Clc1ccc(NCC2CCOCC2)nc1-c1ccnc2[nH]c(C3CCNCC3)cc12 CHEMBL3663788 IC50 81.0 nM
COc1ccc(F)cc1-c1ccnc2[nH]c(C3=CCN(CC(=O)N(C)C)C(C)(C)C3)cc12 CHEMBL3668538 IC50 81.0 nM
O=C(CO)N1CCC(c2cc3c(-c4cncc(NCc5cccnc5)n4)ccnc3[nH]2)CC1 CHEMBL3673536 IC50 81.0 nM
CN1Cc2c(C3=CCC(N[C@@H](Cc4ccc(O)cc4)C(=O)O)CC3)[nH]c3nccc(c23)-c2cc(F)ccc21 CHEMBL3969672 IC50 81.0 nM
CC(=O)c1cnc2ccc(-c3cc(Cl)c(O)c(Cl)c3)nc2c1N[C@H]1CC[C@H](CN(C)C)CC1 CHEMBL3688339 Kd apparent 81.0 nM
COc1ccc(F)cc1-c1c(F)cnc2[nH]c(C3=CCN([C@H]4CC[C@@H](C(=O)O)CC4)CC3)cc12 CHEMBL4851229 IC50 81.0 nM
CC(C)N1c2cc(Nc3nccc(-c4cccc5ncccc45)n3)ccc2N(C)C(=O)[C@H]1C CHEMBL4752747 IC50 81.6 nM
COc1ccccc1-c1ccnc2[nH]c(C3CCN(CC(=O)N(C)C)CC3)cc12 CHEMBL3668523 IC50 82.0 nM
COc1ccc(F)cc1-c1ccnc2[nH]c(C3=CCN(CC(=O)N(C)C)[C@@H](CO)C3)cc12 CHEMBL3668535 IC50 82.0 nM
CN1Cc2c(C3=CCN([C@H]4CC[C@H](CC(=O)O)CC4)CC3)[nH]c3nccc(c23)-c2cc(F)c(F)cc21 CHEMBL3975804 IC50 82.0 nM
Nc1nccc(-c2cc3c([nH]2)C(C2CCC2)CNC3=O)n1 CHEMBL497995 IC50 83.0 nM
COc1ccc(F)cc1-c1c(F)cnc2[nH]c(C3=CCN(CC(=O)N4CCC(O)CC4)CC3)cc12 CHEMBL3668562 IC50 83.0 nM
COc1ccc(F)cc1-c1ccnc2[nH]c(C3=CCN(CC(=O)N4CC(O)C4)C(C)(C)C3)cc12 CHEMBL3673490 IC50 83.0 nM
CNC(=O)N1C2C=C(c3[nH]c4nccc5c4c3CN(C)c3ccc(F)cc3-5)CC1CCC2 CHEMBL3950866 IC50 83.0 nM
COc1ccc(F)cc1-c1ccnc2[nH]c(C3=CCN([C@H]4CC[C@H](C(=O)O)CC4)CC3)cc12 CHEMBL4855780 IC50 83.0 nM
CNC(=O)N1CC=C(c2cc3c(-c4cccc(F)c4F)ccnc3[nH]2)CC1 CHEMBL3668492 IC50 84.0 nM
CNC(=O)C1CC=C(c2cc3c(-c4cncc(OCc5cccc(F)c5)n4)ccnc3[nH]2)CC1 CHEMBL3673550 IC50 84.0 nM
CC(C(=O)O)=C1CCC(N2CC=C(c3[nH]c4nccc5c4c3CN(C)c3ccc(F)cc3-5)CC2)CC1 CHEMBL3977776 IC50 84.0 nM
CN1CC[C@H](c2c(OP(=O)(O)O)cc(O)c3c(=O)cc(-c4ccccc4Cl)oc23)[C@H](O)C1 CHEMBL4594423 IC50 84.0 nM
COc1cc(F)ccc1-c1ccnc2[nH]c(C3CCN(C(C)=O)CC3)cc12 CHEMBL5173492 IC50 84.0 nM
COc1ccc(F)cc1-c1ccnc2[nH]c(C3=C[C@H](C)N(S(C)(=O)=O)CC3)cc12 CHEMBL3668524 IC50 85.0 nM
CNC(=O)N1CC=C(c2[nH]c3ncc(F)c(-c4cc(F)ccc4OC)c3c2C#N)CC1 CHEMBL3668531 IC50 85.0 nM
CN1Cc2c(C3=CCN(S(C)(=O)=O)CC3)[nH]c3nccc(c23)-c2ccccc21 CHEMBL3898182 IC50 85.0 nM
CN1CCC(c2cc3c(-c4cccc(NCc5ccc6cc[nH]c6c5)n4)ccnc3[nH]2)CC1 CHEMBL3668430 IC50 86.0 nM
COc1ccc(F)cc1-c1c(C#N)cnc2[nH]c(C3=CC4CN(CC(=O)N(C)C)CC4C3)cc12 CHEMBL3668543 IC50 86.0 nM
CN1Cc2c(C3=CCC(NCC(=O)O)CC3)[nH]c3nccc(c23)-c2cc(F)ccc21 CHEMBL3969174 IC50 86.0 nM
CN1Cc2c(C3=CCN(CC(=O)N4CCC[C@H]4CO)CC3)[nH]c3ncc(F)c(c23)-c2cc(F)ccc21 CHEMBL3982110 IC50 86.0 nM
CN(CCO)C(=O)CN1C2C=C(c3[nH]c4nccc5c4c3CN(C)c3ccc(F)cc3-5)CC1CCC2 CHEMBL3907123 IC50 86.0 nM
COc1ccc(F)cc1-c1ccnc2[nH]c(C3=CCC(N4CCC(CC(=O)O)CC4)CC3)cc12 CHEMBL4865444 IC50 86.0 nM
Clc1ccc(NCC2CCCOC2)nc1-c1ccnc2[nH]c(C3CCNCC3)cc12 CHEMBL3663789 IC50 87.0 nM
COc1ccc(F)cc1-c1c(C#N)cnc2[nH]c(C3=CC4CN(S(C)(=O)=O)CC4C3)cc12 CHEMBL3668542 IC50 87.0 nM
NC(=O)C1CC=C(c2cc3c(-c4cncc(OCc5cccc(F)c5)n4)ccnc3[nH]2)CC1 CHEMBL3673551 IC50 87.0 nM
CN1Cc2c(C3=CC4CNCC4C3)[nH]c3nccc(c23)-c2cc(F)ccc21 CHEMBL3951695 IC50 88.0 nM
CN1Cc2c(C3=CCN(C4CCC(C(C#N)C(=O)O)CC4)CC3)[nH]c3nccc(c23)-c2cc(F)ccc21 CHEMBL3971069 IC50 88.0 nM
CN1Cc2c(C3=CCN(CC(=O)N4CC(CO)C4)CC3)[nH]c3ncc(F)c(c23)-c2cc(F)ccc21 CHEMBL3908119 IC50 89.0 nM
COc1ccc(F)cc1-c1ccnc2[nH]c(C3=CCC(C(=O)NS(C)(=O)=O)CC3)cc12 CHEMBL4855187 IC50 89.0 nM
COc1ccc(F)cc1-c1c(F)cnc2[nH]c(C3=CC4CCC(C3)N4CC(=O)N(C)C)cc12 CHEMBL3969365 IC50 90.0 nM
COc1ccc(F)cc1-c1ccnc2[nH]c(C3CN(CCN4CCOCC4)C3)cc12 CHEMBL3668442 IC50 90.0 nM
COc1ccc(F)cc1-c1c(F)cnc2[nH]c(C3CCN(CC(=O)N(C)C)CC3)cc12 CHEMBL3668521 IC50 90.0 nM
COc1ccc(F)cc1-c1c(C#N)cnc2[nH]c(C3CCN(CC(=O)N(C)C)CC3)cc12 CHEMBL3668540 IC50 90.0 nM
CN1Cc2c(C3=CCCNCC3)[nH]c3nccc(c23)-c2cc(F)ccc21 CHEMBL3942621 IC50 90.0 nM
CN1Cc2c(C3=CCN([C@H]4CC[C@H](CC(=O)O)CC4)CC3)[nH]c3nccc(c23)-c2ccccc21 CHEMBL3910044 IC50 90.0 nM
CC[C@H](Nc1nc(NCc2cccnc2)c2ncn(C(C)C)c2n1)[C@@H](C)O CHEMBL1922219 IC50 90.0 nM
CN1CCC(c2cc3c(-c4cccc(NCC5CCN(C)C5)n4)ccnc3[nH]2)CC1 CHEMBL3668429 IC50 91.0 nM
COc1ccc(F)cc1-c1ccnc2[nH]c(C3=C[C@H]4CN(S(C)(=O)=O)C[C@H]4C3)cc12 CHEMBL3668528 IC50 91.0 nM
CN(CCO)C(=O)CN1CCC(c2[nH]c3nccc4c3c2CN(C)c2ccc(F)cc2-4)CC1 CHEMBL3892247 IC50 91.0 nM
CN1Cc2c(C3=CCC(N[C@@H](CO)C(=O)O)CC3)[nH]c3nccc(c23)-c2cc(F)ccc21 CHEMBL3911825 IC50 91.0 nM
CC(=O)N[C@@H]1CCC[C@H](C(=O)Nc2cc(-c3cnn4c3CCCCC4)c(Cl)cn2)C1 CHEMBL4786995 IC50 92.0 nM
CN1CCCC(c2cc3c(-c4nc(NCc5ccccc5)ccc4Cl)ccnc3[nH]2)C1 CHEMBL3663754 IC50 93.0 nM
COc1ccc(F)cc1-c1ccnc2[nH]c(C3=C[C@@H](CO)N(CC(=O)N(C)C)CC3)cc12 CHEMBL3668527 IC50 93.0 nM
CNC(=O)N1C[C@H]2CC(c3cc4c(-c5cc(F)ccc5OC)ccnc4[nH]3)=C[C@H]2C1 CHEMBL3668550 IC50 93.0 nM
CNS(=O)(=O)CC(=O)N1CC2C=C(c3cc4c(-c5cc(F)ccc5OC)ccnc4[nH]3)CC2C1 CHEMBL3668556 IC50 93.0 nM
CN1Cc2c(C3CCN(CC(=O)N4CCC[C@H]4CO)CC3)[nH]c3nccc(c23)-c2cc(F)ccc21 CHEMBL3967032 IC50 93.0 nM
CS(=O)(=O)N1CC=C(c2[nH]c3nccc4c3c2COc2ccc(F)cc2-4)CC1 CHEMBL3929678 IC50 94.0 nM
CN1Cc2c(C3=CC4CN(CC(=O)N5CC(O)C5)CC4C3)[nH]c3nccc(c23)-c2cc(F)ccc21 CHEMBL3933775 IC50 94.0 nM
CNC(=O)N1CC=C(c2[nH]c3nccc4c3c2CN(C)c2ncccc2-4)CC1 CHEMBL3953907 IC50 94.0 nM
COc1ccc(F)cc1-c1ccnc2[nH]c(C3=CCC(N[C@H](C(=O)O)C(C)(C)C)CC3)cc12 CHEMBL3668520 IC50 95.0 nM
Nc1nccc(-c2cc3c([nH]2)[C@H](CCF)CNC3=O)n1 CHEMBL451570 IC50 96.0 nM
CN1CCC(c2cc3c(-c4nc(NCC5CC5)ccc4Cl)ccnc3[nH]2)CC1 CHEMBL3668423 IC50 96.0 nM
CN1Cc2c(C3=C[C@H]4CC[C@@H](C3)N4S(C)(=O)=O)[nH]c3nccc(c23)-c2cc(F)ccc21 CHEMBL3901001 IC50 96.0 nM
CN1Cc2c(C3=CCNCC3)[nH]c3nccc(c23)-c2ccccc21 CHEMBL3914925 IC50 96.0 nM
COc1cc(F)ccc1-c1cc(NC(=O)[C@H]2CCC[C@@H](NC(C)=O)C2)ncc1Cl CHEMBL4755256 IC50 96.0 nM
CN1Cc2c(C3=C[C@H]4CC[C@@H](C3)N4CC(=O)N3CC(O)C3)[nH]c3nccc(c23)-c2cc(F)ccc21 CHEMBL3906898 IC50 97.0 nM
CN1Cc2c(C3=CC4CCCC(C3)N4CC(=O)N3CC(O)C3)[nH]c3nccc(c23)-c2cc(F)ccc21 CHEMBL3941567 IC50 98.0 nM
C=CC(=O)Nc1ccc(C(=O)N2CCCC(Nc3ncc(SCc4ncc(C(C)(C)C)o4)s3)C2)cc1 CHEMBL4781539 IC50 98.0 nM
COc1ccc(F)cc1-c1c(F)cnc2[nH]c(C3=CCN(C4CCC(CC(=O)O)CC4)CC3)cc12 CHEMBL3668563 IC50 99.0 nM
CN(CC(O)CO)C(=O)CN1CC2C=C(c3[nH]c4nccc5c4c3CN(C)c3ccc(F)cc3-5)CC2C1 CHEMBL3986185 IC50 99.0 nM