CCc1cc(Oc2cccc(N(Cc3cccc(OC(F)(F)C(F)F)c3)C[C@@H](O)C(F)(F)F)c2)ccc1Cl CHEMBL67129 IC50 0.77 nM
O=C(N[C@@H]1CCC(F)(F)C1)N[C@@](Cc1ccccc1)(c1cc(F)cc(OC(F)(F)C(F)F)c1)c1ccc(Cl)cn1 CHEMBL2152167 IC50 1.0 nM
CC(C)Oc1cc([C@@](Cc2ccccc2)(NC(=O)C(O)C(O)(C(F)(F)F)C(F)(F)F)c2cc(F)cc(OC(F)(F)C(F)F)c2)ccc1F CHEMBL4439823 IC50 1.0 nM
CC(C)Oc1cc([C@@](Cc2ccccc2)(NC[C@H](O)CC(F)(F)F)c2cc(F)cc(OC(F)(F)C(F)F)c2)ccc1F CHEMBL3814374 IC50 1.3 nM
OC(CN[C@@](Cc1ccccc1)(c1cc(F)cc(OC(F)(F)C(F)F)c1)c1ccc(Cl)cn1)CC(F)(F)F CHEMBL3813720 IC50 1.5 nM
COc1ccc(-c2c(F)cc(C(=O)O)cc2F)cc1C1=C(CN2C(=O)O[C@H](c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2C)CC(C)(C)CC1 CHEMBL3906320 IC50 1.5 nM
COc1ccc(-c2ccc(C(=O)O)cc2C(F)(F)F)cc1C1=C(CN2C(=O)O[C@H](c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2C)CC(C)(C)CC1 CHEMBL3914103 IC50 1.6 nM
CC(C)Oc1cc([C@@](Cc2ccccc2)(NC[C@@H](O)C(F)(F)F)c2cc(F)cc(OC(F)(F)C(F)F)c2)ccc1F CHEMBL3813836 IC50 1.8 nM
COc1cc(F)c(-c2ccc(C(=O)O)cc2Cl)cc1C1=C(CN2C(=O)O[C@H](c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2C)CC(C)(C)CC1 CHEMBL3965631 IC50 1.9 nM
COc1cc(C)c(-c2ccc(C(=O)O)cc2C)cc1C1=C(CN2C(=O)O[C@H](c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2C)CC(C)(C)CC1 CHEMBL3955558 IC50 1.9 nM
O=C(NCCC(F)(F)F)N[C@@](Cc1ccccc1)(c1cc(F)cc(OC(F)(F)C(F)F)c1)c1ccc(Cl)cn1 CHEMBL2152180 IC50 2.0 nM
NC(C(=O)N[C@@](Cc1ccccc1)(c1cc(F)cc(OC(F)(F)C(F)F)c1)c1ccc(F)c(OC2CC2)c1)C(O)(C(F)(F)F)C(F)(F)F CHEMBL4574163 IC50 2.0 nM
CC(C)Oc1cc([C@@](Cc2ccccc2)(NC[C@@H](O)CC(F)(F)F)c2cc(F)cc(OC(F)(F)C(F)F)c2)ccc1F CHEMBL3814963 IC50 2.5 nM
COc1cc(F)c(-c2ccc(C(=O)O)cc2F)cc1C1=C(CN2C(=O)O[C@H](c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2C)CC(C)(C)CC1 CHEMBL3982930 IC50 2.5 nM
CC(C)Oc1cc([C@@](Cc2ccccc2)(NC[C@H](O)C(F)(F)F)c2cc(F)cc(OC(F)(F)C(F)F)c2)ccc1F CHEMBL3814418 IC50 2.9 nM
O[C@H](CN(Cc1cccc(OC(F)(F)C(F)F)c1)c1cccc(Oc2ccccc2)c1)C(F)(F)F CHEMBL303954 IC50 3.0 nM
CCc1cc(Oc2cccc(N(Cc3cccc(OC(F)(F)C(F)F)c3)CC(O)C(F)(F)F)c2)ccc1Cl CHEMBL69563 IC50 3.0 nM
CCOC(=O)N1c2ccc(C(F)(F)F)cc2[C@@H](N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C(=O)OC)C[C@H]1CC CHEMBL479527 IC50 3.0 nM
O=C(NCC(F)(F)F)N[C@@](Cc1ccccc1)(c1cc(F)cc(OC(F)(F)C(F)F)c1)c1ccc(Cl)cn1 CHEMBL2152183 IC50 3.0 nM
COc1ncc(-c2sc(C)nc2C)cc1-c1cnc(N2CC(F)C2)nc1CN1C(=O)O[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C CHEMBL3913846 IC50 3.0 nM
COc1ncc(-c2c(C)nn(C)c2C)cc1-c1cnc(N2CC(F)C2)nc1CN1C(=O)O[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C CHEMBL3932157 IC50 3.0 nM
COc1ncc(-c2c(C)noc2C)cc1-c1cnc(N2CC(F)C2)nc1CN1C(=O)O[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C CHEMBL3907705 IC50 3.0 nM
CC(C)Oc1cc([C@@](Cc2ccccc2)(NC(=O)C(N)C(O)(C(F)(F)F)C(F)(F)F)c2cc(F)cc(OC(F)(F)C(F)F)c2)ccc1F CHEMBL4457286 IC50 3.0 nM
COc1cc(F)c(-c2ccc(C(=O)O)cc2C)cc1C1=C(CN2C(=O)O[C@H](c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2C)CC(C)(C)CC1 CHEMBL3972983 IC50 3.9 nM
O=C(NC1CCC(F)(F)C1)N[C@@](Cc1ccccc1)(c1cc(F)cc(OC(F)(F)C(F)F)c1)c1ccc(Cl)cn1 CHEMBL2152166 IC50 5.0 nM
COc1ncc(-c2c(C)n[nH]c2C)cc1-c1cnc(N2CC(F)C2)nc1CN1C(=O)O[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C CHEMBL3971102 IC50 5.0 nM
COc1ncc(C(C)C)cc1-c1cnc(N2CC(F)(F)C2)nc1CN1C(=O)O[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C CHEMBL3938675 IC50 5.0 nM
COc1ncc(C(C)C)cc1-c1cnc(N2CCC2)nc1CN1C(=O)O[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C CHEMBL3927563 IC50 5.0 nM
COc1ncc(-c2c(C)cc(C(=O)OC(C)(C)C)cc2C)cc1-c1ccc(N2CC(F)(F)C2)nc1CN1C(=O)O[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C CHEMBL3979835 IC50 5.0 nM
COc1ncc(-c2ccc(C(=O)O)cc2C)cc1-c1ccc(N2CC(F)(F)C2)nc1CN1C(=O)O[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C CHEMBL3970660 IC50 5.0 nM
C[C@H]1[C@@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)OC(=O)N1CC1=C(c2cc(F)cc(-c3ccc(C(=O)O)cc3C(F)(F)F)c2)CCC(C)(C)C1 CHEMBL3953367 IC50 5.0 nM
CC(C)Oc1cc([C@@](Cc2ccccc2)(NCC(O)C(O)(C(F)(F)F)C(F)(F)F)c2cc(F)cc(OC(F)(F)C(F)F)c2)ccc1F CHEMBL4552555 IC50 5.0 nM
CC(C)(C)Oc1cc([C@@](Cc2ccccc2)(NC(=O)C(N)C(O)(C(F)(F)F)C(F)(F)F)c2cc(F)cc(OC(F)(F)C(F)F)c2)ccc1F CHEMBL4469874 IC50 5.0 nM
COc1ncc(-c2ccc(C(=O)O)cc2Cl)cc1C1=C(CN2C(=O)O[C@H](c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2C)CC(C)(C)CC1 CHEMBL3948773 IC50 5.3 nM
COc1ncc(-c2ccc(C(=O)O)cc2C)cc1C1=C(CN2C(=O)O[C@H](c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2C)CC(C)(C)CC1 CHEMBL3986115 IC50 5.4 nM
COc1ccc(-c2ccc(C(=O)O)cc2C)cc1C1=C(CN2C(=O)O[C@H](c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2C)CC(C)(C)CC1 CHEMBL3927226 IC50 5.8 nM
CCNC(=O)c1ccc(-c2ccc(F)c(C3=C(CN4C(=O)O[C@H](c5cc(C(F)(F)F)cc(C(F)(F)F)c5)[C@@H]4C)CC(C)(C)CC3)c2)c(C(F)(F)F)c1 CHEMBL3898351 IC50 5.9 nM
O=C(NC1CCC(F)(F)C1)N[C@@](Cc1ccccc1)(c1cc(F)cc(C(F)(F)F)c1)c1ccc(Cl)cn1 CHEMBL2152158 IC50 6.0 nM
O=C(NC1CCCC1)N[C@@](Cc1ccccc1)(c1cc(F)cc(OC(F)(F)C(F)F)c1)c1ccc(Cl)cn1 CHEMBL2152165 IC50 6.0 nM
O=C(NCC(F)(F)C(F)(F)F)N[C@@](Cc1ccccc1)(c1cc(F)cc(OC(F)(F)C(F)F)c1)c1ccc(Cl)cn1 CHEMBL2152181 IC50 6.0 nM
CN(Cc1cnc(N2CCC(c3nc4c(c(C5CCC(F)(F)CC5)c3[C@@H](F)c3ccc(C(F)(F)F)cc3)[C@@H](O)CC(C)(C)C4)CC2)nc1)S(C)(=O)=O CHEMBL3934696 IC50 6.0 nM
CC(C)S(=O)(=O)N(C)Cc1cnc(N2CCC(c3nc4c(c(C5CCC(F)(F)CC5)c3[C@@H](F)c3ccc(C(F)(F)F)cc3)[C@@H](O)CC(C)(C)C4)CC2)nc1 CHEMBL3912224 IC50 6.0 nM
COc1ncc(-c2ccc(C(=O)O)cc2C)cc1-c1ccc(N2CC(F)C2)nc1CN1C(=O)O[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C CHEMBL3895147 IC50 6.0 nM
CC(C)Oc1cc([C@@](Cc2ccccc2)(NC(=O)C(N)C(O)C(F)(F)F)c2cc(F)cc(OC(F)(F)C(F)F)c2)ccc1F CHEMBL4439856 IC50 6.0 nM
C[C@H]1[C@@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)OC(=O)N1CC1=C(c2cc(-c3ccc(C(=O)O)cc3C(F)(F)F)ccc2F)CCC(C)(C)C1 CHEMBL3987174 IC50 6.4 nM
Cc1cc(C(=O)O)ccc1-c1cc(C2=C(CN3C(=O)O[C@H](c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H]3C)CC(C)(C)CC2)ccc1F CHEMBL3941193 IC50 6.6 nM
COc1cc(C(F)(F)F)c(-c2ccc(C(=O)O)cc2)cc1C1=C(CN2C(=O)O[C@H](c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2C)CC(C)(C)CC1 CHEMBL3915159 IC50 6.9 nM
CC1(C)Cc2nc(C3CCCC3)c([C@@H](F)c3ccc(C(F)(F)F)cc3)c(C3CCCCC3)c2[C@@H](O)C1 CHEMBL1081288 IC50 7.0 nM
O=C(N[C@H]1CCC(F)(F)C1)N[C@@](Cc1ccccc1)(c1cc(F)cc(OC(F)(F)C(F)F)c1)c1ccc(Cl)cn1 CHEMBL2152168 IC50 7.0 nM
O=C(NC1CC(F)(F)C1)N[C@@](Cc1ccccc1)(c1cc(F)cc(OC(F)(F)C(F)F)c1)c1ccc(Cl)cn1 CHEMBL2152170 IC50 7.0 nM
COc1ncc(-c2c(C)cc(C(=O)O)cc2C)cc1-c1cnc(N2CC(F)C2)nc1CN1C(=O)O[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C CHEMBL3966328 IC50 7.0 nM
COc1ncc(-c2c(C)cc(C(=O)O)cc2C)cc1-c1ccc(N2CC(F)(F)C2)nc1CN1C(=O)O[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C CHEMBL3942160 IC50 7.0 nM
COc1ccc(C(C)C)cc1-c1ccc(C(F)(F)F)cc1CN1C(=O)O[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C CHEMBL1800622 IC50 7.0 nM
C[C@H]1[C@@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)OC(=O)N1CC1=C(c2cc(-c3ccc(C(=O)N4CCOCC4)cc3C(F)(F)F)ccc2F)CCC(C)(C)C1 CHEMBL3926422 IC50 7.1 nM
COc1ccc(-c2ccc(C(=O)O)cc2Cl)cc1C1=C(CN2C(=O)O[C@H](c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2C)CC(C)(C)CC1 CHEMBL3932190 IC50 7.3 nM
O[C@H](CN1c2ccccc2N(Cc2cccc(OC(F)(F)F)c2)CC1c1cccc(OC(F)F)c1)C(F)(F)F CHEMBL4114495 IC50 7.5 nM
C[C@H]1[C@@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)OC(=O)N1CC1=C(c2cc(-c3ccc(C(=O)O)cc3C(F)(F)F)ccc2Cl)CCC(C)(C)C1 CHEMBL3912017 IC50 7.5 nM
COc1cc(C(F)(F)F)c(-c2ccc(C(=O)O)cc2C)cc1C1=C(CN2C(=O)O[C@H](c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2C)CC(C)(C)CC1 CHEMBL3928848 IC50 7.6 nM
CCCNC(=O)N[C@@](Cc1ccccc1)(c1cc(F)cc(OC(F)(F)C(F)F)c1)c1ccc(Cl)cn1 CHEMBL2152179 IC50 8.0 nM
O[C@H](CN1c2ccccc2N(CC2=CCCCC2)C[C@H]1c1cccc(OC(F)(F)F)c1)C(F)(F)F CHEMBL3982660 IC50 8.0 nM
CC1(C)Cc2nc(C3CCN(c4ncc(OCC(CO)CO)cn4)CC3)c([C@@H](F)c3ccc(C(F)(F)F)cc3)c(C3CCC(F)(F)CC3)c2[C@@H](O)C1 CHEMBL3929958 IC50 8.0 nM
COc1ncc(-c2c(C)cc(-c3n[nH]c(=O)o3)cc2C)cc1-c1cnc(N2CC(F)C2)nc1CN1C(=O)O[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C CHEMBL3933008 IC50 8.0 nM
COc1ccc(-c2ccc(C(=O)O)c(F)c2F)cc1C1=C(CN2C(=O)O[C@H](c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2C)CC(C)(C)CC1 CHEMBL3949935 IC50 8.4 nM
COc1ccc(-c2ccc(C(=O)O)cc2C(F)(F)F)nc1C1=C(CN2C(=O)O[C@H](c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2C)CC(C)(C)CC1 CHEMBL3897170 IC50 8.9 nM
O=C(N[C@@](Cc1ccccc1)(c1cc(F)cc(OC(F)(F)C(F)F)c1)c1ccc(Cl)cn1)N1CC(F)(F)C(F)(F)C1 CHEMBL2152175 IC50 9.0 nM
OC(CN[C@@](Cc1ccccc1)(c1cc(F)cc(C(F)(F)F)c1)c1ccc(Cl)cn1)CC(F)(F)F CHEMBL3814359 IC50 9.0 nM
O[C@H](CNCC(Cc1ccccc1)(c1cc(F)cc(OC(F)(F)C(F)F)c1)c1ccc(Cl)cn1)C(F)(F)F CHEMBL3679155 IC50 9.0 nM
Cc1ccc(CC(CNC[C@@H](O)C(F)(F)F)(c2cccc(OC(F)(F)F)c2)c2cccc(OC(F)(F)F)c2)cc1 CHEMBL3683926 IC50 9.0 nM
CC(C)c1nc2c(c3c1[C@@H](c1ccc(C(F)(F)F)cc1)OC31CCOCC1)[C@@H](O)CC1(CC1)[C@H]2O CHEMBL3894287 IC50 9.0 nM
CC(C)(O)CCOc1cnc(N2CCC(c3nc4c(c(C5CCC(F)(F)CC5)c3[C@@H](F)c3ccc(C(F)(F)F)cc3)[C@@H](O)CC(C)(C)C4)CC2)nc1 CHEMBL3975279 IC50 9.0 nM
CCn1nc(C)c(-c2cnc(OC)c(-c3cnc(N4CC(F)C4)nc3CN3C(=O)O[C@H](c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H]3C)c2)c1C CHEMBL3925726 IC50 9.0 nM
COc1ncc(-c2ccc(C(=O)O)cc2C)cc1-c1cnc(N2CC(F)(F)C2)nc1CN1C(=O)O[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C CHEMBL3933239 IC50 9.0 nM
COc1ncc(-c2ccc(C(=O)O)cc2C)cc1-c1cnc(N2CC(F)(F)C2)nc1CN1C(=O)O[C@H](c2cc(F)cc(C(F)(F)F)c2)[C@@H]1C CHEMBL3916319 IC50 9.0 nM
COc1ncc(-c2ccc(C(=O)O)cc2C)cc1-c1ccc(N2CCOCC2)nc1CN1C(=O)O[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C CHEMBL3947462 IC50 9.0 nM
COc1ccc(-c2ccc(C(=O)O)cc2C)cc1-c1ccc(C(F)(F)F)cc1CN1C(=O)O[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C CHEMBL4873416 IC50 9.0 nM
COc1cc(C(F)(F)F)c(-c2ccc(C(=O)O)cc2F)cc1C1=C(CN2C(=O)O[C@H](c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2C)CC(C)(C)CC1 CHEMBL3891904 IC50 9.1 nM
C[C@H]1[C@@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)OC(=O)N1CC1=C(c2ccc(F)c(-c3ccc(C(=O)O)cc3C(F)(F)F)c2)CCC(C)(C)C1 CHEMBL3920961 IC50 9.6 nM
Cc1c(Cl)ccc(OCC(=O)Nc2ccc(-c3nc4cc(C#N)ccc4o3)cc2)c1C CHEMBL261502 IC50 10.0 nM
O=C(NC1CC1(F)F)N[C@@](Cc1ccccc1)(c1cc(F)cc(OC(F)(F)C(F)F)c1)c1ccc(Cl)cn1 CHEMBL2152169 IC50 10.0 nM
CN1CCC(Oc2cnc(N3CCC(c4nc5c(c(C6CCC(F)(F)CC6)c4[C@@H](F)c4ccc(C(F)(F)F)cc4)[C@@H](O)CC(C)(C)C5)CC3)nc2)CC1 CHEMBL3986429 IC50 10.0 nM
CC1(C)Cc2nc(C3CCN(c4ncc(OCCCS(C)(=O)=O)cn4)CC3)c([C@@H](F)c3ccc(C(F)(F)F)cc3)c(C3CCC(F)(F)CC3)c2[C@@H](O)C1 CHEMBL3938925 IC50 10.0 nM
COc1ncc(-c2c(C)cc(C(=O)O)cc2C)cc1-c1cnc(N2CCOCC2)nc1CN1C(=O)O[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C CHEMBL3978643 IC50 10.0 nM
COc1ncc(-c2c(C)cc(-c3n[nH]c(=O)o3)cc2C)cc1-c1cnc(N2CCOCC2)nc1CN1C(=O)O[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C CHEMBL3949582 IC50 10.0 nM
COc1ncc(-c2ccc(C(=O)Nc3nnn[nH]3)cc2C)cc1-c1cnc(N2CC(F)C2)nc1CN1C(=O)O[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C CHEMBL3959462 IC50 10.0 nM
Cc1cc(C(=O)O)ccc1-c1cccc(C2=C(CN3C(=O)O[C@H](c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H]3C)CC(C)(C)CC2)c1 CHEMBL3926760 IC50 10.7 nM
Cc1cc(Br)ccc1OCC(=O)Nc1ccc(-c2nc3cc(C#N)ccc3o2)cc1 CHEMBL259502 IC50 11.0 nM
O[C@H](CN1c2ccccc2N(Cc2cccc(OC(F)(F)F)c2)C[C@H]1c1cccc(OC(F)(F)C(F)F)c1)C(F)(F)F CHEMBL3805284 IC50 11.0 nM
O[C@H](CN1c2ccccc2N(C2C=Cc3ccccc32)CC1c1cccc(OC(F)(F)C(F)F)c1)C(F)(F)F CHEMBL4109643 IC50 11.0 nM
COc1cc([C@H]2OC3(CCOCC3)c3c2c(C(C)C)nc2c3[C@@H](O)CC3(CC3)C2)ccc1C(F)(F)F CHEMBL3933248 IC50 11.0 nM
COc1cc([C@H]2OC3(CCOCC3)c3c2c(C(C)C)nc2c3[C@@H](O)CC3(CC3)[C@H]2O)ccc1C(F)(F)F CHEMBL3982297 IC50 11.0 nM
CC1(C)Cc2nc(C3CCN(c4ncc(OC[C@H](O)CO)cn4)CC3)c([C@@H](F)c3ccc(C(F)(F)F)cc3)c(C3CCC(F)(F)CC3)c2[C@@H](O)C1 CHEMBL4114338 IC50 11.0 nM
COc1ncc(C(C)C)cc1-c1cnc(N2CC(F)C2)nc1CN1C(=O)O[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C CHEMBL3907016 IC50 11.0 nM
COc1ncc(-c2ccc(C(=O)Nc3nnn[nH]3)cc2C)cc1-c1cnc(N2CCOCC2)nc1CN1C(=O)O[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C CHEMBL3951553 IC50 11.0 nM
NC(C(=O)N[C@](Cc1ccccc1)(c1ccc(F)cc1)c1cc(F)cc(C(F)(F)F)c1)C(O)(C(F)(F)F)C(F)(F)F CHEMBL4473304 IC50 11.0 nM
Cc1cc(C(=O)O)ccc1-c1ccc(Cl)c(C2=C(CN3C(=O)O[C@H](c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H]3C)CC(C)(C)CC2)c1 CHEMBL3919350 IC50 11.4 nM
COc1cc(C)c(-c2ccc(C(=O)O)cc2)cc1C1=C(CN2C(=O)O[C@H](c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2C)CC(C)(C)CC1 CHEMBL3942098 IC50 11.6 nM
Cc1cc(C(=O)O)ccc1-c1cc(F)cc(C2=C(CN3C(=O)O[C@H](c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H]3C)CC(C)(C)CC2)c1 CHEMBL3954404 IC50 11.9 nM
CC[C@@H]1C[C@H](N(Cc2cc(Cl)cc(C(F)(F)F)c2)c2nnn(C)n2)c2nc(C)ccc2N1C(=O)OC(C)C CHEMBL2017388 IC50 12.0 nM
O[C@H](CN1c2ccccc2N(Cc2cc(Cl)cc(Cl)c2)C[C@H]1c1cccc(C(F)(F)F)c1)C(F)(F)F CHEMBL3908802 IC50 12.0 nM
O[C@H](CN1c2ccccc2N(C2CCCc3ccccc32)CC1c1cccc(C(F)(F)F)c1)C(F)(F)F CHEMBL4109886 IC50 12.0 nM
CCOc1ncc(C(F)(F)F)cc1-c1cnc(N2CC(F)C2)nc1CN1C(=O)O[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C CHEMBL3917772 IC50 12.0 nM
CCCn1nc(C)c(-c2cnc(OC)c(-c3cnc(N4CC(F)C4)nc3CN3C(=O)O[C@H](c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H]3C)c2)c1C CHEMBL3952524 IC50 12.0 nM
COc1ncc(-c2ccc(C(=O)O)cc2C)cc1-c1cnc(N2CC(F)C2)nc1CN1C(=O)O[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C CHEMBL3938288 IC50 12.0 nM
COc1ncc(-c2ccc(-c3n[nH]c(=O)o3)cc2C)cc1-c1cnc(N2CC(F)C2)nc1CN1C(=O)O[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C CHEMBL3950475 IC50 12.0 nM
COc1ncc(-c2ccc(C(=O)O)cc2C)cc1-c1cnc(N2CC(F)C2)nc1CN1C(=O)O[C@H](c2cc(F)cc(C(F)(F)F)c2)[C@@H]1C CHEMBL3946753 IC50 12.0 nM
COc1cc(C(F)(F)F)c(-c2ccc(C(=O)O)cc2Cl)cc1C1=C(CN2C(=O)O[C@H](c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2C)CC(C)(C)CC1 CHEMBL3897353 IC50 12.3 nM
COc1ncc(-c2ccc(C(=O)O)cc2C(C)C)cc1C1=C(CN2C(=O)O[C@H](c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2C)CC(C)(C)CC1 CHEMBL3980987 IC50 12.6 nM
Cc1cc(C(=O)O)ccc1-c1ccc(Cl)c(-c2ccc(C(F)(F)F)cc2CN2C(=O)O[C@H](c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2C)c1 CHEMBL4875851 IC50 12.7 nM
Cc1cc(C#N)cc2nc(-c3ccc(NC(=O)CN4CCN(c5cccc(C(F)(F)F)c5)CC4)cc3)oc12 CHEMBL1643160 IC50 13.0 nM
CC(C)Oc1ccc(F)cc1-c1ccc(N2CCC(CNC(=O)c3ccc(-c4nc5cc(C#N)cc(C(C)C)c5o4)cc3)CC2)nc1 CHEMBL1682748 IC50 13.0 nM
CC[C@@H]1C[C@H](N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2nnn(C)n2)c2cc(C(F)(F)F)ccc2N1C(=O)OC(C)C CHEMBL2032415 IC50 13.0 nM
CC1(C)Cc2nc(C3CCN(c4ncc(OCC(C)(CO)CO)cn4)CC3)c([C@@H](F)c3ccc(C(F)(F)F)cc3)c(C3CCC(F)(F)CC3)c2[C@@H](O)C1 CHEMBL3906719 IC50 13.0 nM
COc1ncc(-c2ccc(C(=O)O)cc2C)cc1-c1cnc(N2CCOCC2)nc1CN1C(=O)O[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C CHEMBL3976354 IC50 13.0 nM
COc1ncc(-c2ccc(C(=O)O)cc2F)cc1C1=C(CN2C(=O)O[C@H](c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2C)CC(C)(C)CC1 CHEMBL3978985 IC50 13.0 nM
COc1cc(F)c(C(C)C)cc1-c1ccc([N+](=O)[O-])cc1CN1C(=O)O[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C CHEMBL1935001 IC50 13.3 nM
O[C@H](CF)CN1c2cccc(-c3cccc(OC(F)(F)F)c3)c2OC[C@@H]1c1cccc(OC(F)(F)C(F)F)c1 CHEMBL602678 IC50 14.0 nM
O[C@H](CN[C@@](Cc1ccccc1)(c1cc(F)cc(OC(F)(F)C(F)F)c1)c1ccc(Cl)cn1)C(F)(F)F CHEMBL3813777 IC50 14.0 nM
O[C@H](CNCC(Cc1ccccc1)(c1cccc(OC(F)(F)F)c1)c1cccc(OC(F)(F)F)c1)C(F)(F)F CHEMBL3683925 IC50 14.0 nM
O[C@H](CN1c2ccccc2N(Cc2cccc(OC(F)F)c2)CC1c1cccc(OC(F)F)c1)C(F)(F)F CHEMBL4106766 IC50 14.0 nM
COc1ncc(C(F)(F)F)cc1-c1cnc(N2CC(F)C2)nc1CN1C(=O)O[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C CHEMBL3895246 IC50 14.0 nM
COc1ncc(C(C)(O)C(F)(F)F)cc1-c1cnc(N2CC(F)C2)nc1CN1C(=O)O[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C CHEMBL3944969 IC50 14.0 nM
COc1cc(F)c(-c2ccc(C(=O)O)cc2)cc1C1=C(CN2C(=O)O[C@H](c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2C)CC(C)(C)CC1 CHEMBL3943442 IC50 14.6 nM
CCc1c(C)c(Cl)c2c(c1OC(=O)C1(C)C3CCC1CC3)Oc1ccc([C@@H](O)CC(C)(C)C)c(OC)c1C(=O)O2 CHEMBL425892 IC50 15.0 nM
N#Cc1ccc2oc(-c3ccc(NC(=O)COc4ccc(Cl)c5c4CCC5)cc3)nc2c1 CHEMBL259710 IC50 15.0 nM
Cc1cc(C#N)cc2nc(-c3ccc(NC(=O)CN4CCN(c5ccc(C(F)(F)F)cn5)CC4)cc3)oc12 CHEMBL1682747 IC50 15.0 nM
CC[C@@H]1C[C@H](N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2nnn(CCCO)n2)c2cc(C(F)(F)F)ccc2N1C(=O)OC(C)C CHEMBL2029489 IC50 15.0 nM
CC[C@@H]1C[C@H](N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2nnn(CCC#N)n2)c2cc(C(F)(F)F)ccc2N1C(=O)OC(C)C CHEMBL2029482 IC50 15.0 nM
COc1ccc([C@@](Cc2ccccc2)(NC(=O)NC2CCCC2)c2cc(F)cc(C(F)(F)F)c2)cn1 CHEMBL2165719 IC50 15.0 nM
CC(C)c1nc2c(c3c1[C@@H](c1ccc(C(F)(F)F)cc1)OC31CCOCC1)[C@@H](O)CC1(CC1)C2 CHEMBL3971960 IC50 15.0 nM
COc1ncc(-c2c(C)n[nH]c2C)cc1-c1cnc(N2CC(F)(F)C2)nc1CN1C(=O)O[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C CHEMBL3946027 IC50 15.0 nM
COc1ncc(-c2c(C)cc(C(=O)O)cc2C)cc1-c1cnc(N2CC(F)C2)nc1CN1C(=O)O[C@H](c2cc(F)cc(C(F)(F)F)c2)[C@@H]1C CHEMBL3893066 IC50 15.0 nM
COc1ncc(-c2ccc(C(=O)OC(C)(C)C)cc2C)cc1-c1ccc(N2CC(F)(F)C2)nc1CN1C(=O)O[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C CHEMBL3971757 IC50 15.0 nM
COc1ncc(-c2ccc(C(=O)OC(C)(C)C)cc2C)cc1-c1ccc(N2CC(F)C2)nc1CN1C(=O)O[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C CHEMBL3924456 IC50 15.0 nM
COC(=O)c1ccc(-c2cc(C3=C(CN4C(=O)O[C@H](c5cc(C(F)(F)F)cc(C(F)(F)F)c5)[C@@H]4C)CC(C)(C)CC3)c(OC)cc2F)c(C)c1 CHEMBL3971977 IC50 15.0 nM
Cc1cc(C(=O)O)ccc1-c1cc(C2=C(CN3C(=O)O[C@H](c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H]3C)CC(C)(C)CC2)ccc1C CHEMBL3970749 IC50 15.9 nM
C[C@H]1[C@@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)OC(=O)N1CC1=C(c2cc(-c3ccc(C(=O)O)cc3F)cc(C(F)(F)F)c2)CCC(C)(C)C1 CHEMBL3907248 IC50 15.9 nM
Cc1cc(C#N)cc2nc(-c3ccc(NC(=O)CN4CCN(c5ccc(C(F)(F)F)cc5)CC4)cc3)oc12 CHEMBL1643161 IC50 16.0 nM
CC[C@@H]1C[C@H](N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2nnn(CCO)n2)c2cc(C(F)(F)F)ccc2N1C(=O)OC(C)C CHEMBL2029483 IC50 16.0 nM
O=C(NC1CCCC1)N[C@@](Cc1ccccc1F)(c1cc(F)cc(C(F)(F)F)c1)c1ccc(Cl)cn1 CHEMBL2165691 IC50 16.0 nM
O[C@H](CN1c2ccc(F)cc2N(Cc2cccc(OC(F)(F)F)c2)CC1c1cccc(OC(F)F)c1)C(F)(F)F CHEMBL4115182 IC50 16.0 nM
O[C@H](CN1c2ccccc2N(Cc2cccc(OC(F)F)c2)C[C@H]1c1cccc(C(F)(F)F)c1)C(F)(F)F CHEMBL3908168 IC50 16.0 nM
CN1CCC(Oc2cnc(N3CCC(c4nc5c(c(C6CCC(F)(F)CC6)c4[C@@H](F)c4ccc(C(F)(F)F)cc4)[C@@H](O)CC(C)(C)C5)CC3)nc2)C1 CHEMBL3892768 IC50 16.0 nM
CC1(C)Cc2nc(C3CCN(c4ncc(OCCCO)cn4)CC3)c([C@@H](F)c3ccc(C(F)(F)F)cc3)c(C3CCC(F)(F)CC3)c2[C@@H](O)C1 CHEMBL3962825 IC50 16.0 nM
COc1ncc(C(C)C)cc1-c1cnc(N2CC(F)C2)nc1CN1C(=O)O[C@H](c2cc(F)cc(F)c2)[C@@H]1C CHEMBL3924433 IC50 16.0 nM
COc1cc(F)c(C(C)C)cc1-c1ccc(SC)cc1CN1C(=O)O[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C CHEMBL1935006 IC50 16.2 nM
COc1cc(F)c(C(C)C)cc1-c1ccc(Cl)cc1CN1C(=O)O[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C CHEMBL1934997 IC50 16.5 nM
COc1cc(F)c(C(C)C)cc1-c1ccc(C)cc1CN1C(=O)O[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C CHEMBL1935003 IC50 16.7 nM
CC(C)c1nc2c(c(C3CCCCC3)c1[C@@H](F)c1ccc(C(F)(F)F)cc1)[C@@H](O)CC1(CCC1)C2 CHEMBL1081450 IC50 17.0 nM
COc1ncc(-c2ccc(C(=O)O)cc2C)cc1-c1ccc(C(F)(F)F)nc1CN1C(=O)N[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C CHEMBL4797108 IC50 17.0 nM
COc1cc(F)c(C(C)C)cc1-c1ccc(C(F)(F)F)cc1CN1C(=O)O[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C CHEMBL1800807 IC50 17.0 nM
COc1cc(F)c(C(C)C)cc1-c1ccc(C(F)(F)F)cc1CN1C(=O)O[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)C1(C)C CHEMBL1800810 IC50 17.8 nM
COc1ncc(-c2ccc(C(=O)O)c(F)c2F)cc1C1=C(CN2C(=O)O[C@H](c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2C)CC(C)(C)CC1 CHEMBL3934300 IC50 17.9 nM
COC(=O)c1c(Cl)ccc(OCC(=O)Nc2ccc(-c3nc4cc(C#N)ccc4o3)cc2)c1C CHEMBL259503 IC50 18.0 nM
N#Cc1ccc2oc(-c3ccc(NC(=O)COc4ccc(Cl)c(C(F)(F)F)c4)cc3)nc2c1 CHEMBL258795 IC50 18.0 nM
CC(C)c1cc(C#N)cc2nc(-c3ccc(C(=O)NC[C@@]4(C)CN(c5ccc(-c6ccccc6OC(F)(F)F)cn5)C(=O)O4)cc3)oc12 CHEMBL1771147 IC50 18.0 nM
COc1cc(F)c(C(C)C)cc1-c1ccc(C(C)(C)F)cc1CN1C(=O)O[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C CHEMBL1935011 IC50 18.0 nM
CC(C)c1nc2c(c3c1[C@@H](c1ccc(C(F)(F)F)cc1)OC31CCOCC1)[C@@H](O)CC(C)(C)C2 CHEMBL3360279 IC50 18.0 nM
CC(C)c1nc2c(c3c1[C@@H](c1ccc(C(F)(F)F)c(C#N)c1)OC31CCOCC1)[C@@H](O)CC1(CC1)C2 CHEMBL3945816 IC50 18.0 nM
COc1ncc(-c2c(C)nn(CC#N)c2C)cc1-c1cnc(N2CC(F)C2)nc1CN1C(=O)O[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C CHEMBL3954716 IC50 18.0 nM
COc1ncc(C(C)C)cc1-c1cnc(N2CCC[C@@H]2C)nc1CN1C(=O)O[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C CHEMBL3895826 IC50 18.0 nM
COc1ccc(-c2ccc(C(=O)O)cc2C)cc1-c1ccc(C(F)(F)F)nc1CN1C(=O)N[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C CHEMBL4781837 IC50 18.0 nM
COc1cc(F)c(C(C)C)cc1-c1ccc(C(F)(F)F)cc1CN1C(=O)O[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)C12CC2 CHEMBL4852781 IC50 18.0 nM
Cc1cc(C#N)cc2nc(-c3ccc(NC(=O)CN4CCN(c5cccc(Cl)c5)CC4)cc3)oc12 CHEMBL1643157 IC50 19.0 nM
CC(C)c1ccccc1-c1ccc(N2CCC(CNC(=O)c3ccc(-c4nc5cc(C#N)cc(C(C)C)c5o4)cc3)CC2)nc1 CHEMBL1684870 IC50 19.0 nM
O[C@H](CNCC(Cc1ccccn1)(c1cccc(OC(F)(F)F)c1)c1cccc(OC(F)(F)F)c1)C(F)(F)F CHEMBL3683923 IC50 19.0 nM
CN1CCN(c2cnc(N3CCC(c4nc5c(c(C6CCC(F)(F)CC6)c4[C@@H](F)c4ccc(C(F)(F)F)cc4)[C@@H](O)CC(C)(C)C5)CC3)nc2)CC1 CHEMBL3958020 IC50 19.0 nM
CC1(C)Cc2nc(C3CCN(c4ncc(CCCCC(=O)O)cn4)CC3)c([C@@H](F)c3ccc(C(F)(F)F)cc3)c(C3CCC(F)(F)CC3)c2[C@@H](O)C1 CHEMBL3977505 IC50 19.0 nM
CC1(C)Cc2nc(C3CCN(c4ncc(C(=O)N5CCOCC5)cn4)CC3)c([C@@H](F)c3ccc(C(F)(F)F)cc3)c(C3CCC(F)(F)CC3)c2[C@@H](O)C1 CHEMBL3896401 IC50 19.0 nM
COc1ncc(-c2c(C)n[nH]c2C)cc1-c1cnc(N2CCC2)nc1CN1C(=O)O[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C CHEMBL3941988 IC50 19.0 nM
COc1ccc(-c2ccc(C(=O)O)cc2C)cc1-c1cnc(N(C)C)nc1CN1C(=O)O[C@H](c2cc(Cl)cc(Cl)c2)[C@@H]1C CHEMBL4876430 IC50 19.0 nM
COc1cc(F)c(C(C)C)cc1-c1ccc(SC(F)(F)F)cc1CN1C(=O)O[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C CHEMBL1935009 IC50 19.6 nM
COc1cc(F)c(C(C)C)cc1-c1ccc(Br)cc1CN1C(=O)O[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C CHEMBL1934998 IC50 19.8 nM
CC(C)c1cccc(Oc2cccc(N(Cc3cccc(OC(F)(F)C(F)F)c3)CC(O)C(F)(F)F)c2)c1 CHEMBL69699 IC50 20.0 nM
CC[C@@H]1C[C@H](N(Cc2cc(Cl)cc(C(F)(F)F)c2)c2nnn(C)n2)c2nc(C(F)(F)F)ccc2N1C(=O)OC(C)C CHEMBL2017387 IC50 20.0 nM
O=C(NC1CCCC1)N[C@@](Cc1ccccc1)(c1cc(F)cc(C(F)(F)F)c1)c1ccc(Cl)cn1 CHEMBL2152152 IC50 20.0 nM
O=C(NC1CCCCC1(F)F)N[C@@](Cc1ccccc1)(c1cc(F)cc(C(F)(F)F)c1)c1ccc(Cl)cn1 CHEMBL2152162 IC50 20.0 nM
Cc1sc(N[C@](Cc2ccccc2)(c2cc(F)cc(OC(F)(F)C(F)F)c2)c2ccc(Cl)cn2)nc1C(F)(F)F CHEMBL3116157 IC50 20.0 nM
Fc1cc(OC(F)(F)C(F)F)cc([C@@](Cc2ccccc2)(Nc2nc3c(s2)CCCC3)c2ccc(Cl)cn2)c1 CHEMBL3116159 IC50 20.0 nM
C[C@H](c1cccc(C(F)(F)F)c1)N1C[C@@H](c2cccc(C(F)(F)F)c2)N(C[C@@H](O)C(F)(F)F)c2ccccc21 CHEMBL3805336 IC50 20.0 nM
O[C@H](CN1c2ccccc2N(Cc2cccc(OC(F)(F)F)c2)C[C@H]1c1ccc(Cl)cc1)C(F)(F)F CHEMBL3916464 IC50 20.0 nM
COc1ncc(-c2c(C)n[nH]c2C)cc1-c1cnc(N2CCCC2)nc1CN1C(=O)O[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C CHEMBL3927335 IC50 20.0 nM
COc1ncc(-c2ccc(C(=O)O)cc2C)cc1-c1ccc(C(F)(F)F)nc1CN1C(=O)O[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C CHEMBL4852134 IC50 20.0 nM
C[C@H]1[C@@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)OC(=O)N1CC1=C(c2cc(-c3ccc(C(=O)O)cc3Cl)ccc2F)CCC(C)(C)C1 CHEMBL3910458 IC50 20.3 nM
CC[C@@H]1C[C@H](N(Cc2cc(C#N)cc(C(F)(F)F)c2)c2nnn(C)n2)c2nc(C)ccc2N1C(=O)OC(C)C CHEMBL2017389 IC50 21.0 nM
CCC(C)OC(=O)N1C[C@@H](N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ncc(-c3cnn(C)c3)cn2)C[C@H]1CC CHEMBL3685771 IC50 21.0 nM
CC(C)(O)COc1cnc(N2CCC(c3nc4c(c(C5CCC(F)(F)CC5)c3[C@@H](F)c3ccc(C(F)(F)F)cc3)[C@@H](O)CC(C)(C)C4)CC2)nc1 CHEMBL3947718 IC50 21.0 nM
O[C@H]1CC2(CCC2)Cc2nc(C3CCCC3)c([C@@H](F)c3ccc(C(F)(F)F)cc3)c(C3CCCCC3)c21 CHEMBL1081802 IC50 22.0 nM
CC(C)c1cc(C#N)cc2nc(-c3ccc(C(=O)NCC4CCN(c5nccc(C(F)(F)F)n5)CC4)cc3)oc12 CHEMBL1684850 IC50 22.0 nM
Cc1ccc(OC(C)C)c(-c2ccc(N3CCC(CNC(=O)c4ccc(-c5nc6cc(C#N)cc(C(C)C)c6o5)cc4)CC3)nc2)c1 CHEMBL1684866 IC50 22.0 nM
CC(C)c1cc(C#N)cc2nc(-c3ccc(C(=O)NC[C@]4(C)CN(c5ccc(-c6ccccc6OC(F)(F)F)cn5)C(=O)O4)cc3)oc12 CHEMBL1771146 IC50 22.0 nM
CC[C@@H]1C[C@H](N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2nnn(C)n2)c2nc(C)ccc2N1C(=O)OC(C)C CHEMBL2017198 IC50 22.0 nM
O[C@H](CN[C@@](Cc1ccccc1)(c1cc(F)cc(C(F)(F)F)c1)c1ccc(Cl)cn1)C(F)(F)F CHEMBL3814646 IC50 22.0 nM
C[C@@H](O)COc1cnc(N2CCC(c3nc4c(c(C5CCC(F)(F)CC5)c3[C@@H](F)c3ccc(C(F)(F)F)cc3)[C@@H](O)CC(C)(C)C4)CC2)nc1 CHEMBL4113068 IC50 22.0 nM
COc1ncc(-c2c(C)nn(CC(N)=O)c2C)cc1-c1cnc(N2CC(F)C2)nc1CN1C(=O)O[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C CHEMBL3918135 IC50 22.0 nM
COc1ncc(-c2ccc(C(=O)OC(C)(C)C)cc2C)cc1-c1ccc(N2CCOCC2)nc1CN1C(=O)O[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C CHEMBL3974503 IC50 22.0 nM
COc1cc(F)c(C(C)C)cc1-c1ccc(C(F)(F)F)cc1[C@@H]1CC[C@H]2[C@@H](c3cccc(C(F)(F)F)c3)OC(=O)N12 CHEMBL3657496 IC50 22.0 nM
Cc1cc(C)c2oc(-c3ccc(NC(=O)COc4ccc(F)cc4C)cc3)nc2c1 CHEMBL409318 IC50 23.0 nM
CC(C)c1nc2c(c(C3CCCCC3)c1[C@@H](F)c1ccc(C(F)(F)F)cc1)[C@@H](O)CC(C)(C)C2 CHEMBL1081287 IC50 23.0 nM
CC[C@@H]1C[C@H](N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2nnn(C)n2)c2nc(C(F)(F)F)ccc2N1C(=O)OC(C)C CHEMBL2017195 IC50 23.0 nM
CC[C@@H]1C[C@H](N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2nnn(CC#N)n2)c2cc(C(F)(F)F)ccc2N1C(=O)OC(C)C CHEMBL2029481 IC50 23.0 nM
Cc1ccc(C[C@](NC(=O)NC2CCCC2)(c2cc(F)cc(C(F)(F)F)c2)c2ccc(Cl)cn2)cc1 CHEMBL2165690 IC50 23.0 nM
CC[C@@H]1C[C@H](N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ncc(-c3cnn(C)c3)cn2)CN1C(=O)OC(C)C CHEMBL3685781 IC50 23.0 nM
COc1ncc(-c2c(C)n[nH]c2C)cc1-c1cnc(N2CCOCC2)nc1CN1C(=O)O[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C CHEMBL3971568 IC50 23.0 nM
COc1ccc(-c2ccc(C(=O)O)cc2C)cc1-c1ccc(C(F)(F)F)nc1CN1C(=O)O[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C CHEMBL4853626 IC50 23.0 nM
COc1ccc(-c2ccc(C(=O)O)cc2F)cc1C1=C(CN2C(=O)O[C@H](c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2C)CC(C)(C)CC1 CHEMBL3957430 IC50 23.2 nM
COc1cc(F)c(C(C)C)cc1-c1ccc(C#N)cc1CN1C(=O)O[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C CHEMBL1935000 IC50 23.3 nM
COc1cc(F)c(C(C)C)cc1-c1ccc(I)cc1CN1C(=O)O[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C CHEMBL1934999 IC50 23.5 nM
CC(C)c1nc2c(c(-c3ccc(F)cc3)c1[C@@H](F)c1ccc(C(F)(F)F)cc1)[C@@H](O)CC1(CCC1)C2 CHEMBL1086624 IC50 24.0 nM
COc1cc(F)c(C(C)C)cc1-c1ccc(N2CCC(CNC(=O)c3ccc(-c4nc5cc(C#N)cc(C(C)C)c5o4)cc3)CC2)nc1 CHEMBL1684865 IC50 24.0 nM
CCOC(=O)N1c2c(C)cc(C(F)(F)F)nc2[C@@H](N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2nnn(C)n2)C[C@H]1CC CHEMBL2017386 IC50 24.0 nM
CC[C@@H]1C[C@H](N(Cc2cc(Cl)cc(Cl)c2)c2nnn(C)n2)c2nc(C)ccc2N1C(=O)OC(C)C CHEMBL2017391 IC50 24.0 nM
CC[C@@H]1C[C@H](N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2cc(C)no2)c2cc(C(F)(F)F)ccc2N1C(=O)OC(C)C CHEMBL2032417 IC50 24.0 nM
CC(C)(O)c1ccc(C2CN(Cc3cccc(OC(F)(F)F)c3)c3ccccc3N2C[C@@H](O)C(F)(F)F)cc1 CHEMBL4107916 IC50 24.0 nM
COc1cc(C2=C(CN3C(=O)O[C@H](c4cc(C(F)(F)F)cc(C(F)(F)F)c4)[C@@H]3C)CC(C)(C)CC2)cc(-c2ccc(C(=O)O)cc2C)c1 CHEMBL3924471 IC50 24.3 nM
COc1cc(F)c(C(C)C)cc1-c1ccc(C2CC2)cc1CN1C(=O)O[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C CHEMBL1935013 IC50 24.8 nM
COc1cc(F)c(C(C)C)cc1-c1ccc(C(C)(C)C)cc1CN1C(=O)O[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C CHEMBL1935005 IC50 24.9 nM
COc1cc(F)c(C(C)C)cc1-c1ccc(F)cc1CN1C(=O)O[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C CHEMBL1934996 IC50 25.0 nM
O=C(NC1CCCC1)NC(Cc1ccccc1)(c1cccc(OC(F)(F)C(F)F)c1)c1ccc(Cl)cn1 CHEMBL2165681 IC50 25.0 nM
CC[C@H]1C[C@@H](N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ncc(-c3cnn(C)c3)cn2)CN1C(=O)N1CCCCC1 CHEMBL3685783 IC50 25.0 nM
FC(F)(F)CCNCC(Cc1ccccc1)(c1cccc(OC(F)(F)F)c1)c1cccc(OC(F)(F)F)c1 CHEMBL3683927 IC50 25.0 nM
O[C@H](CN1c2ccccc2N(Cc2cccc(OC(F)(F)F)c2)CC1c1ccc(-c2ccccc2)cc1)C(F)(F)F CHEMBL4108875 IC50 25.0 nM
C[C@H](O)COc1cnc(N2CCC(c3nc4c(c(C5CCC(F)(F)CC5)c3[C@@H](F)c3ccc(C(F)(F)F)cc3)[C@@H](O)CC(C)(C)C4)CC2)nc1 CHEMBL3985193 IC50 25.0 nM
COc1ccc(-c2ccc(C(=O)O)cc2C)cc1-c1cnc(N(C)C)nc1CN1C(=O)O[C@H](c2cc(Cl)cc(C(F)(F)F)c2)[C@@H]1C CHEMBL4856008 IC50 25.0 nM
COc1cc(F)c(C(C)C)cc1-c1ccc(C(F)(F)F)cc1CN1C[C@@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)OC1=O CHEMBL1800808 IC50 25.6 nM
O[C@@H](CN1c2cccc(-c3cccc(OC(F)(F)F)c3)c2OC[C@@H]1c1cccc(OC(F)(F)C(F)F)c1)C(F)(F)F CHEMBL602483 IC50 26.0 nM
Cc1cc(C)c2c(c1)[C@@H](N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1nnn(C)n1)CCCN2C[C@H]1CC[C@H](C(=O)O)CC1 CHEMBL2017179 IC50 26.0 nM
CC[C@@H]1C[C@H](N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2cc(C)[nH]n2)c2cc(C(F)(F)F)ccc2N1C(=O)OC(C)C CHEMBL2032416 IC50 26.0 nM
O=C(NC1CCCC1)N[C@@](Cc1ccccc1)(c1cc(F)cc(C(F)(F)F)c1)c1ccc(F)cn1 CHEMBL2165717 IC50 26.0 nM
Cc1cc(C(=O)O)ccc1-c1cnc(C)c(-c2cnc(N3CC(F)C3)nc2CN2C(=O)O[C@H](c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2C)c1 CHEMBL3895903 IC50 26.0 nM
CC(C)Oc1cc([C@@](Cc2ccccc2)(NCC(N)C(O)(C(F)(F)F)C(F)(F)F)c2cc(F)cc(OC(F)(F)C(F)F)c2)ccc1F CHEMBL4468692 IC50 26.0 nM
CCNC(=O)N[C@@](Cc1ccccc1)(c1cc(F)cc(OC(F)(F)C(F)F)c1)c1ccc(Cl)cn1 CHEMBL2152182 IC50 27.0 nM
COc1cc(C(F)(F)F)c(-c2ccc(C(=O)O)c(F)c2)cc1C1=C(CN2C(=O)O[C@H](c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2C)CC(C)(C)CC1 CHEMBL3919949 IC50 27.0 nM
COc1cc(F)c(C(C)C)cc1-c1ccc(S(=O)(=O)C(F)(F)F)cc1CN1C(=O)O[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C CHEMBL1935099 IC50 27.1 nM
Cc1ccccc1OCC(=O)Nc1ccc(-c2nc3cc(C#N)cc(C(C)(C)O)c3o2)cc1 CHEMBL593709 IC50 28.0 nM
CC(C)Oc1ccc(C(F)(F)F)cc1-c1ccc(N2CCC(CNC(=O)c3ccc(-c4nc5cc(C#N)cc(C(C)C)c5o4)cc3)CC2)nc1 CHEMBL1684867 IC50 28.0 nM
CN(CCO)c1cnc(N2CCC(c3nc4c(c(C5CCC(F)(F)CC5)c3[C@@H](F)c3ccc(C(F)(F)F)cc3)[C@@H](O)CC(C)(C)C4)CC2)nc1 CHEMBL3956886 IC50 28.0 nM
COc1ncc(-c2ccc(C(=O)O)cc2C)cc1-c1ccc(C(F)(F)F)cc1CN1C(=O)N(C)[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C CHEMBL4755391 IC50 28.0 nM
COC(=O)c1ccc(-c2cnc(OC)c(C3=C(CN4C(=O)O[C@H](c5cc(C(F)(F)F)cc(C(F)(F)F)c5)[C@@H]4C)CC(C)(C)CC3)c2)c(C)c1 CHEMBL3951447 IC50 28.4 nM
CC1(C)Cc2nc(C3CCN(c4ncc(OC[C@@H](O)CO)cn4)CC3)c([C@H](F)c3ccc(C(F)(F)F)cc3)c(C3CCC(F)(F)CC3)c2[C@H](O)C1 CHEMBL3961778 IC50 28.5 nM
CC(C)Oc1ccccc1-c1ccc(N2CCC(CNC(=O)c3ccc(-c4nc5cc(C#N)cc(C(C)C)c5o4)cc3)CC2)nc1 CHEMBL1684869 IC50 29.0 nM
CCOC(=O)N1c2ccc(C(F)(F)F)nc2[C@@H](N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2nnn(C)n2)C[C@H]1CC CHEMBL2017394 IC50 29.0 nM
CC[C@@H]1C[C@H](N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2nnn(CCN)n2)c2cc(C(F)(F)F)ccc2N1C(=O)OC(C)C CHEMBL2029484 IC50 29.0 nM
CC(C)c1nc2c(c3c1[C@@H](c1ccc(C(C)(C)C)cc1)OC31CCCC1)[C@@H](O)CC(C)(C)C2 CHEMBL3359665 IC50 29.0 nM
O[C@H](CN1c2ccccc2N(CC2CCOCC2)C[C@H]1c1cccc(OC(F)(F)F)c1)C(F)(F)F CHEMBL3959235 IC50 29.0 nM
CN(C)C(=O)c1cnc(N2CCC(c3nc4c(c(C5CCC(F)(F)CC5)c3[C@@H](F)c3ccc(C(F)(F)F)cc3)[C@@H](O)CC(C)(C)C4)CC2)nc1 CHEMBL3950806 IC50 29.0 nM
COc1ncc(-c2ccc(-c3n[nH]c(=O)o3)cc2C)cc1-c1cnc(N2CCOCC2)nc1CN1C(=O)O[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C CHEMBL3923841 IC50 29.0 nM
COc1ccc(-c2ccccc2C)cc1-c1ccc(C(F)(F)F)cc1CN1C(=O)O[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C CHEMBL4859118 IC50 29.48 nM
OC(CN(Cc1cccc(OC(F)(F)C(F)F)c1)c1cccc(Oc2ccc(F)cc2)c1)C(F)(F)F CHEMBL71333 IC50 30.0 nM
OC(CN(Cc1cccc(OC(F)(F)C(F)F)c1)c1cccc(Oc2cccc(Cl)c2Cl)c1)C(F)(F)F CHEMBL308436 IC50 30.0 nM
OC(CN(Cc1cccc(OC(F)(F)C(F)F)c1)c1cccc(Oc2cccc(OC(F)(F)F)c2)c1)C(F)(F)F CHEMBL302797 IC50 30.0 nM
COc1c([C@@H](O)CC(C)C)ccc2c1C(=O)Oc1c(Cl)c(C)c(C)c(OC(=O)C3(C)C4CCC3CC4)c1O2 CHEMBL363716 IC50 30.0 nM
COc1c([C@@H](O)CC(C)(C)C)ccc2c1C(=O)Oc1c(Cl)c(C)c(C)c(OC(=O)C3(C)C4CCC3CC4)c1O2 CHEMBL362080 IC50 30.0 nM
OC(CN(Cc1cccc(OC(F)(F)C(F)F)c1)c1cccc(Oc2cccc(CC(F)(F)F)c2)c1)C(F)(F)F CHEMBL237396 IC50 30.0 nM
CC[C@@H]1C[C@H](N(Cc2cc(F)cc(C(F)(F)F)c2)c2nnn(C)n2)c2nc(C)ccc2N1C(=O)OC(C)C CHEMBL2017390 IC50 30.0 nM
O=C(NC1CCCC1)NC(Cc1ccccc1)(c1cc(F)cc(C(F)(F)F)c1)c1ccc(Cl)cn1 CHEMBL2165706 IC50 30.0 nM
CC[C@@H]1C[C@H](N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ncc(-c3cnn(C)c3)cn2)CN1c1nc(N2CCC(O)CC2)ncc1Cl CHEMBL3685777 IC50 30.0 nM
O[C@H](CNCC(Cc1ccccc1)(c1cc(F)cc(C(F)(F)F)c1)c1ccc(F)cn1)C(F)(F)F CHEMBL3679157 IC50 30.0 nM
COc1ccc(-c2ccc(C(=O)O)cc2C)cc1-c1cnc(N(C)C)nc1CN1C(=O)O[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C CHEMBL4854376 IC50 30.0 nM
CC(C)c1cc(-c2ccc(C(F)(F)F)cc2CN2C(=O)O[C@H](c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2C)c(Cl)cc1F CHEMBL4876714 IC50 30.4 nM
Cc1cc(C)c2oc(-c3ccc(NC(=O)COc4ccc(Br)cc4C)cc3)nc2c1 CHEMBL261062 IC50 31.0 nM
CC1(C)Cc2nc(C3CCCC3)c([C@@H](F)c3ccc(C(F)(F)F)cc3)c(-c3ccc(F)cc3)c2[C@@H](O)C1 CHEMBL1086623 IC50 31.0 nM
Cc1cc(C#N)cc2nc(-c3ccc(NC(=O)COC4CCN(S(=O)(=O)Cc5ccccc5)CC4)cc3)oc12 CHEMBL1642944 IC50 31.0 nM
CC(C)COc1ccccc1-c1ccc(N2CCC(CNC(=O)c3ccc(-c4nc5cc(C#N)cc(C(C)C)c5o4)cc3)CC2)nc1 CHEMBL1681821 IC50 31.0 nM
CC[C@@H]1C[C@H](N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2nnn(C)n2)c2nc(N(C)C)ccc2N1C(=O)OC(C)C CHEMBL2017203 IC50 31.0 nM
O=C(NC1CCCC1)NC(Cc1ccccc1)(c1cccc(OC(F)(F)F)c1)c1ccc(Cl)cn1 CHEMBL2165680 IC50 31.0 nM
O=C(NC1CCCC1)NC(Cc1ccccc1)(c1ccc(Cl)nc1)c1cc(F)cc(C(F)(F)F)c1 CHEMBL2165718 IC50 31.0 nM
CC1(C)Cc2nc(C3CCN(c4ncc(OCCC(F)(F)F)cn4)CC3)c([C@@H](F)c3ccc(C(F)(F)F)cc3)c(C3CCC(F)(F)CC3)c2[C@@H](O)C1 CHEMBL3921049 IC50 31.0 nM
COc1cc(F)c(C(C)C)cc1-c1ccccc1CN1C(=O)O[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C CHEMBL1934995 IC50 31.21 nM
COc1c([C@@H](O)CC(C)(C)C)ccc2c1C(=O)Oc1c(Cl)c(C)c(Br)c(OC(=O)C3(C)C4CCC3CC4)c1O2 CHEMBL363570 IC50 32.0 nM
CC[C@@H]1C[C@H](N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ncc(-c3cnn(C)c3)cn2)CN1C(=O)N1CCOCC1 CHEMBL3685775 IC50 32.0 nM
CNC(=O)c1cnc(N2CCC(c3nc4c(c(C5CCC(F)(F)CC5)c3[C@@H](F)c3ccc(C(F)(F)F)cc3)[C@@H](O)CC(C)(C)C4)CC2)nc1 CHEMBL3983253 IC50 32.0 nM
CC1(C)Cc2nc(C3CCN(c4ncc(OC[C@@H](O)CO)cn4)CC3)c([C@@H](F)c3ccc(C(F)(F)F)cc3)c(C3CCC(F)(F)CC3)c2[C@@H](O)C1 CHEMBL3975992 IC50 32.0 nM
CC1(C)Cc2nc(C3CCN(c4ncc(S(C)(=O)=O)cn4)CC3)c([C@@H](F)c3ccc(C(F)(F)F)cc3)c(C3CCC(F)(F)CC3)c2[C@@H](O)C1 CHEMBL3983100 IC50 32.0 nM
OC(CN1c2cccc(-c3cccc(OC(F)(F)F)c3)c2CCC1c1cccc(OC(F)(F)C(F)F)c1)C(F)(F)F CHEMBL479339 IC50 33.0 nM
CC(C)c1nc2c(c(C3CCCCC3)c1C(=O)c1ccc(C(F)(F)F)cc1)[C@@H](O)CC1(CCC1)C2 CHEMBL1086637 IC50 33.0 nM
CC1(C)Cc2nc(C3CCN(c4ncc(N5CC[C@H](O)C5)cn4)CC3)c([C@@H](F)c3ccc(C(F)(F)F)cc3)c(C3CCC(F)(F)CC3)c2[C@@H](O)C1 CHEMBL3902695 IC50 33.0 nM
Cc1cc(C(=O)O)ccc1-c1nc(C)c(-c2cnc(N3CC(F)C3)nc2CN2C(=O)O[C@H](c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2C)s1 CHEMBL3937783 IC50 33.0 nM
COc1cc(F)c(C(C)C)cc1-c1ccc(S(C)(=O)=O)cc1CN1C(=O)O[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C CHEMBL1935014 IC50 33.5 nM
CC[C@@H]1C[C@H](N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ncc(-c3cn[nH]c3)cn2)CN1C(=O)OC(C)C CHEMBL3685780 IC50 34.0 nM
CSc1cnc(N2CCC(c3nc4c(c(C5CCC(F)(F)CC5)c3[C@@H](F)c3ccc(C(F)(F)F)cc3)[C@@H](O)CC(C)(C)C4)CC2)nc1 CHEMBL3928603 IC50 34.0 nM
COc1ncc(C2CC2)cc1-c1cnc(N2CC(F)C2)nc1CN1C(=O)O[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C CHEMBL3900355 IC50 34.0 nM
COc1ncc(-c2ccc(C(=O)O)cc2C)cc1-c1ccc(C(F)(F)F)cc1CN1C(=O)O[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C CHEMBL4852538 IC50 34.0 nM
CN(CCO)Cc1cnc(N2CCC(c3nc4c(c(C5CCC(F)(F)CC5)c3[C@@H](F)c3ccc(C(F)(F)F)cc3)[C@@H](O)CC(C)(C)C4)CC2)nc1 CHEMBL3980185 IC50 35.0 nM
COc1ncc(-c2ccc(C(=O)O)cc2C)cc1-c1cnc(N2CC(F)C2)nc1CN1C(=O)O[C@H](c2cc(F)cc(F)c2)[C@@H]1C CHEMBL3898489 IC50 35.0 nM
O=C(N[C@@](Cc1ccccc1)(c1cc(F)cc(C(F)(F)F)c1)c1ccc(Cl)cn1)C(O)C(O)(C(F)(F)F)C(F)(F)F CHEMBL4475826 IC50 35.0 nM
CC(C)OC(=O)N1c2ccc(C(F)(F)F)cc2[C@@H](N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2nnn(CCCO)n2)C[C@H]1C CHEMBL2032422 IC50 36.0 nM
O=C(N[C@@](Cc1ccccc1)(c1cc(F)cc(OC(F)(F)C(F)F)c1)c1ccc(Cl)cn1)c1ccc(F)c(C(F)(F)F)c1 CHEMBL2165720 IC50 36.0 nM
N#Cc1ccc([C@@](Cc2ccccc2)(NC(=O)NC2CCCC2)c2cc(F)cc(C(F)(F)F)c2)nc1 CHEMBL2165707 IC50 36.0 nM
COc1ncc(-c2c(C)nn(C(C)C)c2C)cc1-c1cnc(N2CC(F)C2)nc1CN1C(=O)O[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C CHEMBL3898918 IC50 36.0 nM
CC(C)c1cc(C#N)cc2nc(-c3ccc(C(=O)NCC4CCN(c5cccc(C(F)(F)F)n5)CC4)cc3)oc12 CHEMBL1684852 IC50 37.0 nM
CC(C)c1cc(C#N)cc2nc(-c3ccc(C(=O)NC[C@H]4CC[C@@H](c5ccc(C(C)(C)C)cc5)CC4)cc3)oc12 CHEMBL1771123 IC50 37.0 nM
CC(C)OC(=O)N1c2ccc(C(F)(F)F)cc2[C@@H](N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2nnn(CCCO)n2)C[C@H]1C(C)C CHEMBL2032424 IC50 37.0 nM
CC1(C)Cc2nc(C3CCCC3)c3c(c2[C@@H](O)C1)C1(CCCC1)O[C@@H]3c1ccc(C(F)(F)F)cc1 CHEMBL3360275 IC50 37.0 nM
CC1(C)Cc2nc(C3CCN(c4ncc(OCCO)cn4)CC3)c([C@@H](F)c3ccc(C(F)(F)F)cc3)c(C3CCC(F)(F)CC3)c2[C@@H](O)C1 CHEMBL3927830 IC50 37.0 nM
CC1(C)Cc2nc(C3CCN(c4ncc(OCCCCC(=O)O)cn4)CC3)c([C@@H](F)c3ccc(C(F)(F)F)cc3)c(C3CCC(F)(F)CC3)c2[C@@H](O)C1 CHEMBL3911802 IC50 37.0 nM
COc1ccc(-c2ccc(C(=O)O)cc2C)cc1-c1ccc(C(F)(F)F)cc1CN1C(=O)N[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C CHEMBL4763753 IC50 37.0 nM
CC(C)c1cc(C#N)cc2nc(-c3ccc(C(=O)NC[C@H]4CC[C@H](c5ccc(C(C)(C)C)cc5)CC4)cc3)oc12 CHEMBL1771124 IC50 38.0 nM
COc1ncc(Cl)cc1-c1cnc(N2CC(F)C2)nc1CN1C(=O)O[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C CHEMBL3922551 IC50 38.0 nM
COc1ncc(-c2ccc(C(=O)O)cc2C)cc1-c1ccc(C(F)(F)F)cc1CN1C(=O)N[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C CHEMBL4756571 IC50 38.0 nM
CC[C@@H]1C[C@H](N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2nnn(C)n2)c2nc(OC)c(C)cc2N1C(=O)OC(C)C CHEMBL2017384 IC50 38.4 nM
O[C@@H](CN1c2cccc(-c3cccc(OC(F)(F)F)c3)c2CC[C@@H]1c1cccc(OC(F)(F)F)c1)C(F)(F)F CHEMBL490868 IC50 39.0 nM
O[C@@H](CN1c2cccc(-c3cccc(OC(F)(F)F)c3)c2CC[C@@H]1c1cccc(OC(F)(F)C(F)F)c1)C(F)(F)F CHEMBL516439 IC50 39.0 nM
CC1(C)Cc2nc(C3CCCC3)c(Cc3ccc(C(F)(F)F)cc3)c(C3CCCCC3)c2[C@@H](O)C1 CHEMBL1081307 IC50 39.0 nM
Cc1cccc(-c2ccc(N3CCC(CNC(=O)c4ccc(-c5nc6cc(C#N)cc(C(C)C)c6o5)cc4)CC3)nc2)c1 CHEMBL1684863 IC50 39.0 nM
CC[C@@H]1C[C@H](N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ncc(-c3cnn(C)c3)cn2)CN1C(=O)N1CCCC1 CHEMBL3685774 IC50 39.0 nM
COc1ccc(C(C)C)cc1-c1ccc(C(F)(F)F)cc1CN1C(=O)O[C@H](c2ccccc2)[C@@H]1C CHEMBL1800802 IC50 39.3 nM
Cc1cc(C)c2oc(-c3ccc(NC(=O)COc4ccc(Cl)c(C)c4C)cc3)nc2c1 CHEMBL264963 IC50 40.0 nM
CCOC(=O)c1ccc(N2CCN(CC(=O)Nc3ccc(-c4nc5cc(C#N)cc(C)c5o4)cc3)CC2)cc1 CHEMBL1643164 IC50 40.0 nM
CC(C)c1cc(C#N)cc2nc(-c3ccc(C(=O)NCC4CCN(c5ccc(C(F)(F)F)cn5)CC4)cc3)oc12 CHEMBL1684652 IC50 40.0 nM
CC(C)c1cc(C#N)cc2nc(-c3ccc(C(=O)NC[C@H]4CC[C@H](c5ccc(C(F)(F)F)cc5)CC4)cc3)oc12 CHEMBL1771126 IC50 40.0 nM
CC(C)OC(=O)N1c2ccc(C(F)(F)F)cc2[C@@H](N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2nnn(CCN)n2)C[C@H]1C(C)C CHEMBL2029379 IC50 40.0 nM
Fc1cc(OC(F)(F)C(F)F)cc([C@@](Cc2ccccc2)(Nc2nc(C(F)(F)F)c(Br)s2)c2ccc(Cl)cn2)c1 CHEMBL3116160 IC50 40.0 nM
Cc1nc(N[C@](Cc2ccccc2)(c2cc(F)cc(OC(F)(F)C(F)F)c2)c2ccc(Cl)cn2)sc1C CHEMBL3116161 IC50 40.0 nM
Fc1cc(C(F)(F)F)cc([C@@](Cc2ccccc2)(Nc2nc3c(s2)CCC3)c2ccc(Cl)cn2)c1 CHEMBL3116344 IC50 40.0 nM
Cc1nc(N[C@](Cc2ccccc2)(c2cc(F)cc(C(F)(F)F)c2)c2ccc(Cl)cn2)sc1C CHEMBL3116346 IC50 40.0 nM
Fc1cc(OC(F)(F)C(F)F)cc([C@@](Cc2ccccc2)(Nc2nc3cc(F)cc(F)c3[nH]2)c2ccc(Cl)cn2)c1 CHEMBL3116154 IC50 40.0 nM
COCc1cnc(N2CCC(c3nc4c(c(C5CCC(F)(F)CC5)c3[C@@H](F)c3ccc(C(F)(F)F)cc3)[C@@H](O)CC(C)(C)C4)CC2)nc1 CHEMBL3943115 IC50 40.0 nM
O[C@@H](CN1c2cccc(-c3cc(F)c(F)c(F)c3)c2OC[C@@H]1c1cccc(OC(F)(F)C(F)F)c1)C(F)(F)F CHEMBL600212 IC50 41.0 nM
CCC(CC)OC(=O)N1C[C@@H](N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ncc(-c3cnn(C)c3)cn2)C[C@H]1CC CHEMBL3685768 IC50 41.0 nM
COc1ccc(-c2ccccc2F)cc1-c1ccc(C(F)(F)F)cc1CN1C(=O)O[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C CHEMBL4875002 IC50 41.8 nM
COC(=O)c1c(Cl)ccc(OCC(=O)Nc2ccc(-c3nc4cc(C)cc(C)c4o3)cc2)c1C CHEMBL264964 IC50 42.0 nM
CC(C)OC(=O)N1c2ccc(C(F)(F)F)cc2[C@@H](N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2nnn(C)n2)C[C@H]1C1CC1 CHEMBL2032421 IC50 42.0 nM
CC1(C)Cc2nc(C3CCOCC3)c3c(c2[C@@H](O)C1)C1(CCCC1)O[C@@H]3c1ccc(C(F)(F)F)cc1 CHEMBL3360276 IC50 42.0 nM
CC1(C)Cc2nc(C3CCN(c4ncc(OC(F)F)cn4)CC3)c([C@@H](F)c3ccc(C(F)(F)F)cc3)c(C3CCC(F)(F)CC3)c2[C@@H](O)C1 CHEMBL3905464 IC50 42.0 nM
CCc1ncc(-c2cc(-c3ccc(C(=O)O)cc3C)ccc2OC)c(CN2C(=O)O[C@H](c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2C)n1 CHEMBL4848688 IC50 42.0 nM
CC(C)c1cc(C#N)cc2nc(-c3ccc(C(=O)NCC4CCN(c5ccc(-c6ccccc6)cn5)CC4)cc3)oc12 CHEMBL1684861 IC50 43.0 nM
CC(C)c1nc2c(c3c1[C@@H](c1ccc(C(F)(F)F)c(C#N)c1)OC31CCOCC1)[C@@H](O)CC1(CC1)[C@H]2O CHEMBL3924452 IC50 43.0 nM
CC(OCC(=O)Nc1ccc(-c2nc3cc(C#N)ccc3o2)cc1)(C(F)(F)F)C(F)(F)F CHEMBL597074 IC50 44.0 nM
CC[C@@H]1C[C@H](N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2nnn(CCO)n2)c2nc(C(F)(F)F)ccc2N1C(=O)OC(C)C CHEMBL2017200 IC50 44.0 nM
CC[C@@H]1C[C@H](N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2nnn(CC(=O)OC)n2)c2cc(C(F)(F)F)ccc2N1C(=O)OC(C)C CHEMBL2029486 IC50 44.0 nM
COc1cc(F)c(-c2ccc(C(=O)O)cc2C)cc1-c1ccc(C(F)(F)F)cc1[C@@H]1CC[C@H]2[C@@H](c3cc(C)cc(C(F)(F)F)c3)OC(=O)N12 CHEMBL3657495 IC50 44.65 nM
COc1ncc(C(C)C)cc1-c1ccc(C(F)(F)F)cc1[C@@H]1CC[C@H]2[C@@H](c3cc(C(F)(F)F)cc(C(F)(F)F)c3)OC(=O)N12 CHEMBL3657510 IC50 44.66 nM
OC(CN1c2cccc(-c3cccc(OC(F)(F)F)c3)c2OCC1c1cccc(OC(F)(F)C(F)F)c1)C(F)(F)F CHEMBL601875 IC50 45.0 nM
CC(C)c1nc2c(c3c1[C@@H](c1ccc(C(F)(F)F)cc1)OC31CCCCC1)[C@@H](O)CC(C)(C)C2 CHEMBL3360278 IC50 45.0 nM
CCOCc1cnc(N2CCC(c3nc4c(c(C5CCC(F)(F)CC5)c3[C@@H](F)c3ccc(C(F)(F)F)cc3)[C@@H](O)CC(C)(C)C4)CC2)nc1 CHEMBL3906880 IC50 45.0 nM
CCc1cc(CN2C[C@@H](c3cccc(C(F)(F)F)c3)N(C[C@@H](O)C(F)(F)F)c3ccccc32)ccc1Cl CHEMBL3912106 IC50 45.1 nM
O[C@H](CN1c2ccccc2N(Cc2cc(F)cc(C(F)(F)F)c2)C[C@H]1c1cccc(C(F)(F)F)c1)C(F)(F)F CHEMBL3978954 IC50 45.2 nM
CC(C)c1cc(C#N)cc2nc(-c3ccc(C(=O)NC[C@@H]4CN(c5ccc(-c6ccccc6OC(F)(F)F)cn5)C(=O)O4)cc3)oc12 CHEMBL1771144 IC50 46.0 nM
CC[C@@H]1C[C@H](N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ncc(-c3cnn(C)c3)cn2)CN1C(=O)OCC1CCOCC1 CHEMBL3685767 IC50 46.0 nM
CC1(C)Cc2nc(C3CCN(c4ncc(N5CCC(O)CC5)cn4)CC3)c([C@@H](F)c3ccc(C(F)(F)F)cc3)c(C3CCC(F)(F)CC3)c2[C@@H](O)C1 CHEMBL3975277 IC50 46.0 nM
COc1ccc(-c2ccc(C(=O)O)cc2C)cc1-c1cnc(N2CCC2)nc1CN1C(=O)O[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C CHEMBL4846106 IC50 46.0 nM
COc1cccc(Cl)c1-c1ccc(N2CCC(CNC(=O)c3ccc(-c4nc5cc(C#N)cc(C(C)C)c5o4)cc3)CC2)nc1 CHEMBL1684864 IC50 47.0 nM
CC[C@@H]1C[C@H](N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2nnn(C)n2)c2nc(Br)ccc2N1C(=O)OC(C)C CHEMBL2017197 IC50 47.0 nM
CC(C)OC(=O)N1c2ccc(C(F)(F)F)cc2[C@@H](N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2nnn(CCN)n2)C[C@H]1C CHEMBL2032425 IC50 47.0 nM
CC(C)OC(=O)N1c2ccc(C(F)(F)F)cc2[C@@H](N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2nnn(C)n2)C[C@H]1C(C)C CHEMBL2032420 IC50 47.0 nM
CC(C)c1nc2c(c3c1[C@@H](c1ccc(C(C)(C)C#N)cc1)OC31CCCC1)[C@@H](O)CC(C)(C)C2 CHEMBL3359664 IC50 47.0 nM
CC[C@@H]1C[C@H](N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ncc(-c3cnn(C)c3)cn2)CN1C(=O)OCC(C)(C)C CHEMBL3685765 IC50 47.0 nM
COc1ncc(-c2c(C)cc(C(=O)O)cc2C)cc1-c1ccc(C(F)(F)F)cc1[C@@H]1CC[C@H]2[C@@H](c3cc(C(F)(F)F)cc(C(F)(F)F)c3)OC(=O)N12 CHEMBL3657521 IC50 47.0 nM
COc1cc(F)c(-c2ccc(C(=O)O)cc2C)cc1-c1ccc(C(F)(F)F)cc1[C@@H]1C=C[C@H]2[C@@H](c3cc(C(F)(F)F)cc(C(F)(F)F)c3)OC(=O)N12 CHEMBL3657515 IC50 47.94 nM
Cc1ccc(-c2ccc(N3CCC(CNC(=O)c4ccc(-c5nc6cc(C#N)cc(C(C)C)c6o5)cc4)CC3)nc2)cc1 CHEMBL1684862 IC50 48.0 nM
CC(C)OC(=O)N1c2ccc(C(F)(F)F)cc2[C@@H](N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2nnn(C)n2)C[C@H]1C CHEMBL2032418 IC50 48.0 nM
CC1(C)Cc2nc(C3CCN(c4ncc(CCCC(F)(F)F)cn4)CC3)c([C@@H](F)c3ccc(C(F)(F)F)cc3)c(C3CCC(F)(F)CC3)c2[C@@H](O)C1 CHEMBL3957366 IC50 48.0 nM
Cc1ccccc1OCC(=O)Nc1ccc(-c2nc3cc(Cl)cc([N+](=O)[O-])c3o2)cc1 CHEMBL407147 IC50 49.0 nM
Cc1cc(C#N)cc2nc(-c3ccc(NC(=O)CN4CCN(c5ccccc5)CC4)cc3)oc12 CHEMBL1643153 IC50 49.0 nM
CC[C@@H]1C[C@H](N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2nnn(CC(N)=O)n2)c2cc(C(F)(F)F)ccc2N1C(=O)OC(C)C CHEMBL2029487 IC50 49.0 nM
CC1(C)Cc2nc(C3CCN(c4ncc(N5CCS(=O)(=O)CC5)cn4)CC3)c([C@@H](F)c3ccc(C(F)(F)F)cc3)c(C3CCC(F)(F)CC3)c2[C@@H](O)C1 CHEMBL3945932 IC50 49.0 nM
COc1ccc(-c2ccc(C(=O)O)cc2C)cc1-c1cnc(C(C)(F)F)nc1CN1C(=O)O[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C CHEMBL4851648 IC50 49.0 nM
O[C@@H](CN1c2cccc(-c3cc(F)cc(F)c3)c2OC[C@@H]1c1cccc(OC(F)(F)C(F)F)c1)C(F)(F)F CHEMBL601237 IC50 50.0 nM
O=C(N[C@@H]1CCOC1)N[C@@](Cc1ccccc1)(c1cc(F)cc(C(F)(F)F)c1)c1ccc(Cl)cn1 CHEMBL2152154 IC50 50.0 nM
O=C(N[C@@](Cc1ccccc1)(c1cc(F)cc(OC(F)(F)C(F)F)c1)c1ccc(Cl)cn1)N1CCC[C@@H]1C(F)(F)F CHEMBL2152178 IC50 50.0 nM
Fc1cc(OC(F)(F)C(F)F)cc([C@@](Cc2ccccc2)(Nc2nc3cc(F)ccc3[nH]2)c2ccc(Cl)cn2)c1 CHEMBL3116155 IC50 50.0 nM
COc1ncc(-c2ccc(C(=O)O)cc2C)cc1-c1cnc(N2CC(F)C2)nc1CN1C(=O)O[C@H](c2cccc(OC(F)(F)F)c2)[C@@H]1C CHEMBL3928995 IC50 50.0 nM
COc1ccc(-c2ccc(C(=O)O)cc2OC)cc1C1=C(CN2C(=O)O[C@H](c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2C)CC(C)(C)CC1 CHEMBL3890674 IC50 50.2 nM
CC(C)(OCC(=O)Nc1ccc(-c2nc3cc(C#N)ccc3o2)cc1)C(F)(F)F CHEMBL590630 IC50 51.0 nM
COC(=O)c1cccc(N2CCN(CC(=O)Nc3ccc(-c4nc5cc(C#N)cc(C)c5o4)cc3)CC2)c1 CHEMBL1643162 IC50 51.0 nM
CC(C)c1nc2c(c3c1[C@@H](c1ccc(C(F)(F)F)cc1)OC31CCCC1)[C@@H](O)CC(C)(C)C2 CHEMBL3360269 IC50 51.0 nM
COc1cnc(N2CCC(c3nc4c(c(C5CCC(F)(F)CC5)c3[C@@H](F)c3ccc(C(F)(F)F)cc3)[C@@H](O)CC(C)(C)C4)CC2)nc1 CHEMBL3933247 IC50 51.0 nM
COc1ccc(-c2ccc(C(=O)O)cc2C)cc1-c1cnc(N(C)C)nc1CN1C(=O)O[C@H](c2cc(F)cc(C(F)(F)F)c2)[C@@H]1C CHEMBL4855182 IC50 51.0 nM
Cc1ccccc1OCC(=O)Nc1ccc(-c2nc3cc(C#N)cc(Cl)c3o2)cc1 CHEMBL408221 IC50 52.0 nM
O=C(N[C@@](Cc1ccccc1)(c1cc(F)cc(C(F)(F)F)c1)c1ccc(Cl)cn1)c1ccc(F)c(C(F)(F)F)c1 CHEMBL3814330 IC50 52.0 nM
COc1ncc(-c2c(C)cc(C(=O)O)cc2C)cc1-c1cnc(N2CC(F)(F)C2)cc1CN1C(=O)O[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C CHEMBL3962379 IC50 52.0 nM
Cc1cc(C#N)cc2nc(-c3ccc(NC(=O)CN4CCN(c5ccc(Cl)cc5)CC4)cc3)oc12 CHEMBL1643158 IC50 53.0 nM
CC[C@@H]1C[C@H](N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ncc(-c3cnn(C)c3)cn2)CN1C(=O)OCC1(C)COC1 CHEMBL3685782 IC50 53.0 nM
NC(C(=O)N[C@@](Cc1ccccc1)(c1cc(F)cc(OC(F)(F)C(F)F)c1)c1ccc(Cl)cn1)C(O)(C(F)(F)F)C(F)(F)F CHEMBL4448253 IC50 53.0 nM
COc1cc(F)c(-c2ccc(C(=O)O)cc2C)cc1-c1ccc(C(F)(F)F)cc1[C@@H]1CC[C@H]2[C@@H](c3cc(C(F)(F)F)cc(C(F)(F)F)c3)OC(=O)N12 CHEMBL3657473 IC50 53.7 nM
CC(C)OC(=O)N1c2ccc(C(F)(F)F)cc2[C@@H](N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2nnn(CCN)n2)C[C@H]1C1CC1 CHEMBL2032426 IC50 54.0 nM
CC(C)Cc1cnc(N2CCC(c3nc4c(c(C5CCC(F)(F)CC5)c3[C@@H](F)c3ccc(C(F)(F)F)cc3)[C@@H](O)CC(C)(C)C4)CC2)nc1 CHEMBL3902158 IC50 54.0 nM
CC(C)/C=C/c1cnc(N2CCC(c3nc4c(c(C5CCC(F)(F)CC5)c3[C@@H](F)c3ccc(C(F)(F)F)cc3)[C@@H](O)CC(C)(C)C4)CC2)nc1 CHEMBL3908960 IC50 54.0 nM
COc1ccc(-c2ccc(C(=O)O)cc2C)cc1-c1cnc(C(F)(F)F)cc1CN1C(=O)O[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C CHEMBL4867412 IC50 54.0 nM
COc1cc(F)c(C(C)C)cc1-c1ccc(C(C)C)cc1CN1C(=O)O[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C CHEMBL1935004 IC50 54.1 nM
O=C(c1ccc(C(F)(F)F)cc1)c1c(C2CCCC2)nc2c(c1C1CCCCC1)[C@@H](O)CC1(CCC1)C2 CHEMBL1080543 IC50 55.0 nM
CC[C@@H]1C[C@H](N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2nnn(C)n2)c2nc(C(F)(F)F)ccc2N1C(=O)C(C)C CHEMBL2017403 IC50 55.0 nM
CCC[C@@H]1C[C@H](N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2nnn(C)n2)c2cc(C(F)(F)F)ccc2N1C(=O)OC(C)C CHEMBL2032419 IC50 55.0 nM
COc1ncc(-c2c(C)cc(C(=O)NC3(C#N)CC3)cc2C)cc1-c1ccc(C(F)(F)F)cc1[C@@H]1CC[C@H]2[C@@H](c3cc(C(F)(F)F)cc(C(F)(F)F)c3)NC(=O)N12 CHEMBL4764014 IC50 55.0 nM
COc1ccc(-c2ccc(C(=O)O)cc2C)cc1-c1cnc(N(C)C)nc1CN1C(=O)O[C@H](c2cccc(C(F)(F)F)c2)[C@@H]1C CHEMBL4870761 IC50 55.0 nM
Cc1cc(C)c2oc(-c3ccc(NC(=O)COc4ccc(Cl)c5c4CCC5)cc3)nc2c1 CHEMBL265420 IC50 56.0 nM
CC[C@@H]1C[C@H](N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2nnn(CCCN)n2)c2cc(C(F)(F)F)ccc2N1C(=O)OC(C)C CHEMBL2029490 IC50 56.0 nM
CC[C@@H]1C[C@H](N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2nnn(C(C)C)n2)c2cc(C(F)(F)F)ccc2N1C(=O)OC(C)C CHEMBL2029477 IC50 56.0 nM
Cc1ccc([C@@H]2CN(Cc3cccc(OC(F)(F)F)c3)c3ccccc3N2C[C@@H](O)C(F)(F)F)cc1 CHEMBL3905656 IC50 56.0 nM
COc1cc(F)c(C(C)C)cc1-c1ccc(C(F)(F)F)cc1[C@@H]1CC[C@H]2[C@@H](c3cc(C)cc(C(F)(F)F)c3)OC(=O)N12 CHEMBL3657493 IC50 56.0 nM
COC(=O)c1cccc(-c2ccc(OC)c(C3=C(CN4C(=O)O[C@H](c5cc(C(F)(F)F)cc(C(F)(F)F)c5)[C@@H]4C)CC(C)(C)CC3)c2)c1 CHEMBL3897306 IC50 56.6 nM
O=C1O[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]2CC[C@@H](c3cc(C(F)(F)F)ccc3C3=CCCC3)N12 CHEMBL3657488 IC50 56.63 nM
Cc1ccccc1OCC(=O)Nc1ccc(-c2nc3cc(C#N)ccc3o2)cc1 CHEMBL260546 IC50 57.0 nM
CC[C@@H]1C[C@H](N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C(C)=O)c2cc(C(F)(F)F)ccc2N1C(=O)OC(C)C CHEMBL2032413 IC50 57.0 nM
O[C@H](CN1c2ccccc2N(Cc2cccc(C(F)(F)F)c2)C[C@H]1c1cccc(C(F)(F)F)c1)C(F)(F)F CHEMBL3896050 IC50 57.1 nM
COc1cccc(N2CCN(CC(=O)Nc3ccc(-c4nc5cc(C#N)cc(C)c5o4)cc3)CC2)c1 CHEMBL1641618 IC50 58.0 nM
CC[C@@H]1C[C@H](N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2nnn(CCCl)n2)c2cc(C(F)(F)F)ccc2N1C(=O)OC(C)C CHEMBL2032423 IC50 58.0 nM
CC[C@@H]1C[C@H](N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ncc(-c3cnn(C)c3)cn2)CN1C(=O)OCC(F)(F)F CHEMBL3685769 IC50 59.0 nM
CC1(C)Cc2nc(C3CCN(c4ncc(-c5cccc(C(=O)O)c5)cn4)CC3)c([C@@H](F)c3ccc(C(F)(F)F)cc3)c(C3CCC(F)(F)CC3)c2[C@@H](O)C1 CHEMBL3913264 IC50 59.0 nM
OC(CN(Cc1cccc(OC(F)(F)C(F)F)c1)c1cccc(OCc2cccc(OC(F)(F)F)c2)c1)C(F)(F)F CHEMBL419999 IC50 60.0 nM
CCc1cccc(Oc2cccc(N(Cc3cccc(OC(F)(F)C(F)F)c3)CC(O)C(F)(F)F)c2)c1 CHEMBL67055 IC50 60.0 nM
COc1c([C@@H](O)CC(C)C)ccc2c1C(=O)Oc1c(Cl)c(C)c(Br)c(OC(=O)C3(C)C4CCC3CC4)c1O2 CHEMBL365287 IC50 60.0 nM
OC(CN(Cc1cccc(OC(F)(F)C(F)F)c1)c1cccc(OCc2ccccc2OC(F)(F)F)c1)C(F)(F)F CHEMBL237627 IC50 60.0 nM
CC1(C)Cc2nc(C3CCCC3)c(C(=O)c3ccc(C(F)(F)F)cc3)c(C3CCCCC3)c2[C@@H](O)C1 CHEMBL1080866 IC50 60.0 nM
COc1cc(F)c(C(C)C)cc1-c1ccc(C(F)(F)F)cc1CN1C(=O)O[C@@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]1C CHEMBL3787505 IC50 60.0 nM
O[C@@H](CN1c2ccccc2N(Cc2cccc(OC(F)(F)F)c2)C[C@H]1c1cccc(OC(F)(F)C(F)F)c1)C(F)(F)F CHEMBL3805908 IC50 60.0 nM
COc1ccc(C(C)C)cc1C1=C(CN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ncc(-c3cnn(C)c3)cn2)CC(C)CC1 CHEMBL3955613 IC50 60.0 nM
CC[C@@H]1C[C@H](N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ncc(-c3cnn(C)c3)cn2)CN1C(=O)OC1CCOCC1 CHEMBL3685766 IC50 60.0 nM
CC[C@@H]1C[C@H](N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ncc(N3CCOCC3)cn2)C[C@H](Cc2ccccc2)N1C(=O)OC(C)(C)C CHEMBL4063323 IC50 60.0 nM
CC[C@@H]1C[C@H](N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ncc(N3CCOCC3)cn2)C[C@H](CC)N1C(=O)OC(C)C CHEMBL4064793 IC50 60.0 nM
CC(C)c1cc(C#N)cc2nc(-c3ccc(C(=O)NCC4CCN(c5cc(C(F)(F)F)ccn5)CC4)cc3)oc12 CHEMBL1684854 IC50 61.0 nM
CC[C@@H]1C[C@H](N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2nnn(CC3CC3)n2)c2cc(C(F)(F)F)ccc2N1C(=O)OC(C)C CHEMBL2029480 IC50 61.0 nM
Cc1cc(C(=O)O)ccc1-c1nc(C)c(-c2cnc(N3CC(F)(F)C3)nc2CN2C(=O)O[C@H](c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2C)s1 CHEMBL3952998 IC50 61.0 nM
CC(C)COCc1cnc(N2CCC(c3nc4c(c(C5CCC(F)(F)CC5)c3[C@@H](F)c3ccc(C(F)(F)F)cc3)[C@@H](O)CC(C)(C)C4)CC2)nc1 CHEMBL3954610 IC50 62.0 nM
CC[C@@H]1C[C@H](N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ncc(-c3cnn(C)c3)cn2)C[C@H](CC)N1C(=O)O[C@H]1CC[C@H](C(=O)O)CC1 CHEMBL4075773 IC50 62.0 nM
CC[C@@H]1C[C@H](N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ncc(-c3cnn(C)c3)cn2)CN1C(=O)N(C)C CHEMBL3685776 IC50 63.0 nM
OC(CN1c2cccc(-c3cccc(Cl)c3)c2CCC1c1cccc(OC(F)(F)C(F)F)c1)C(F)(F)F CHEMBL482575 IC50 64.0 nM
Cc1cc(C#N)cc2nc(-c3ccc(NC(=O)CN4CCN(C(=O)OC(C)(C)C)CC4)cc3)oc12 CHEMBL1642947 IC50 64.0 nM
Cc1cc(C#N)cc2nc(-c3ccc(NC(=O)CN4CCN(c5ccccc5C(F)(F)F)CC4)cc3)oc12 CHEMBL1643159 IC50 65.0 nM
CC(C)Oc1ccc(F)cc1-c1ccc(N2C[C@@H](CNC(=O)c3ccc(-c4nc5cc(C#N)cc(C(C)C)c5o4)cc3)OC2=O)nc1 CHEMBL1771142 IC50 66.0 nM
CC[C@@H]1C[C@H](N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2nnn(CCN)n2)c2nc(C(F)(F)F)ccc2N1C(=O)OC(C)C CHEMBL2017199 IC50 66.0 nM
CC[C@@H]1C[C@H](N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2nnn(C)n2)c2nc(C(F)(F)F)ccc2N1C(=O)OC1CCOCC1 CHEMBL2017398 IC50 66.0 nM
CC1(C)Cc2nc(C3CCN(c4ncc(N5CCCCC5)cn4)CC3)c([C@@H](F)c3ccc(C(F)(F)F)cc3)c(C3CCC(F)(F)CC3)c2[C@@H](O)C1 CHEMBL3959172 IC50 66.0 nM
CC(C)c1cc(C#N)cc2nc(-c3ccc(C(=O)NCC4CN(c5ccc(-c6ccccc6OC(F)(F)F)cn5)C(=O)O4)cc3)oc12 CHEMBL1771141 IC50 67.0 nM
Cc1cc(CN2C[C@@H](c3cccc(C(F)(F)F)c3)N(C[C@@H](O)C(F)(F)F)c3ccccc32)cc(Cl)n1 CHEMBL3973593 IC50 67.0 nM
Cc1cc(C#N)cc2nc(-c3ccc(NC(=O)CN4CCN(c5ccccc5Cl)CC4)cc3)oc12 CHEMBL1643156 IC50 69.0 nM
O[C@H](CN1CC(Cc2cccc(OC(F)(F)F)c2)(c2cccc(OC(F)(F)F)c2)c2ccccc21)C(F)(F)F CHEMBL3805524 IC50 69.0 nM
CC[C@@H]1C[C@H](N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ncc(-c3cnn(C)c3)cn2)CN1C(=O)OCC(C)C CHEMBL3685764 IC50 69.0 nM
COc1ccc([C@@H]2CN(Cc3cccc(OC(F)(F)F)c3)c3ccccc3N2C[C@@H](O)C(F)(F)F)cc1 CHEMBL3976405 IC50 69.0 nM
COc1ccc(-c2ccc(C(=O)O)cc2C)cc1-c1cnc(C(F)(F)F)nc1CN1C(=O)O[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C CHEMBL4864055 IC50 69.0 nM
COc1cc(F)c(C(C)C)cc1-c1cnc(N(C)C)cc1[C@@H]1CC[C@H]2[C@@H](c3cc(C(F)(F)F)cc(C(F)(F)F)c3)OC(=O)N12 CHEMBL3657499 IC50 69.73 nM
Cc1cc(C)cc(Oc2cccc(N(Cc3cccc(OC(F)(F)C(F)F)c3)CC(O)C(F)(F)F)c2)c1 CHEMBL433103 IC50 70.0 nM
Cc1cc(C)cc(Oc2cccc(CN(CC(O)C(F)(F)F)c3cccc(Oc4ccccc4)c3)c2)c1 CHEMBL235525 IC50 70.0 nM
O=C(c1ccc(C(F)(F)F)cc1)c1c(C2CCCC2)nc2c(c1C1CCCC1)[C@@H](O)CC1(CCC1)C2 CHEMBL1087412 IC50 70.0 nM
CC(C)c1nc2c(c(C3CCCCC3)c1C(=O)c1ccc(C(F)(F)F)cc1)[C@@H](O)CC(C)(C)C2 CHEMBL1087413 IC50 70.0 nM
CC(C)c1nc2c(c(C3CCCCC3)c1[C@@H](O)c1ccc(C(F)(F)F)cc1)[C@@H](O)CC1(CCC1)C2 CHEMBL1080751 IC50 70.0 nM
COc1ccc(C(C)C)cc1C1=C(CN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ncc(-c3cnn(C)c3)cn2)CC(C(C)(C)C)CC1 CHEMBL3946904 IC50 70.0 nM
COc1ccc(C(C)C)cc1C1=C(CN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ncc(-c3cnn(C)c3)cn2)CC(C)(C)CC1 CHEMBL3913485 IC50 70.0 nM
CC[C@@H]1C[C@H](N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ncc(-c3cnn(C)c3)cn2)CN1C(=O)OC1CCCC1 CHEMBL3685770 IC50 70.0 nM
CC[C@@H]1C[C@H](N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ncc(-c3cnn(C)c3)cn2)CN1C(=O)OCC1(CC)COC1 CHEMBL3685772 IC50 70.0 nM
CC[C@@H]1C[C@H](N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ncc(OC)cn2)C[C@H](Cc2ccccc2)N1C(=O)OC(C)(C)C CHEMBL4070653 IC50 71.0 nM
COc1cc(F)c(C(C)C)cc1-c1ccc(C(F)(F)F)cc1[C@@H]1CC[C@H]2[C@@H](c3cc(F)cc(C(F)(F)F)c3)OC(=O)N12 CHEMBL3657494 IC50 71.0 nM
COc1cc(F)c(C(C)C)cc1-c1ccc(C(C)(C)O)cc1CN1C(=O)O[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C CHEMBL1935012 IC50 71.8 nM
CC12CCC(OCC(=O)Nc3ccc(-c4nc5cc(C#N)ccc5o4)cc3)(CC1)CC2 CHEMBL1642925 IC50 72.0 nM
CC[C@@H]1C[C@H](N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2nnn(C)n2)c2nc(C(F)(F)F)ccc2N1C(=O)OC1CCN(C)CC1 CHEMBL2017399 IC50 72.0 nM
CC[C@@H]1C[C@H](N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ncc(N3CC[C@H](O)C3)cn2)CN1C(=O)OC(C)C CHEMBL3685773 IC50 72.0 nM
CC1(C)Cc2nc(C3CCN(c4ncc(O)cn4)CC3)c([C@@H](F)c3ccc(C(F)(F)F)cc3)c(C3CCC(F)(F)CC3)c2[C@@H](O)C1 CHEMBL3953177 IC50 73.0 nM
O=C1O[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]2CC[C@@H](c3cc(C(F)(F)F)ccc3C3=CCCCC3)N12 CHEMBL3657483 IC50 73.63 nM
CC[C@@H]1C[C@H](N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2noc(C)n2)c2nc(C(F)(F)F)ccc2N1C(=O)OC(C)C CHEMBL2017190 IC50 74.0 nM
CCCn1nnc(N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@H]2C[C@@H](CC)N(C(=O)OC(C)C)c3ccc(C(F)(F)F)cc32)n1 CHEMBL2032427 IC50 74.0 nM
CC(C)c1cc(C#N)cc2nc(-c3ccc(C(=O)NC[C@H]4CC[C@H](c5ccc(Cl)cc5)CC4)cc3)oc12 CHEMBL1771133 IC50 77.0 nM
CC[C@@H]1C[C@H](N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ncc(-c3cnn(C)c3)cn2)CN1c1nc(N2CCC(C(=O)O)CC2)ncc1Cl CHEMBL3685778 IC50 77.0 nM
COc1ncc(-c2c(C)cc(C(=O)O)cc2C)cc1-c1ccc(C(F)(F)F)cc1[C@@H]1CC[C@H]2[C@@H](c3cc(F)cc(C(F)(F)F)c3)OC(=O)N12 CHEMBL3657528 IC50 77.0 nM
CC[C@@H]1C[C@H](N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ncc(Br)cn2)C[C@H](Cc2ccccc2)N1C(=O)OC(C)(C)C CHEMBL4081265 IC50 77.0 nM
CC(C)c1cc(C#N)cc2nc(-c3ccc(C(=O)NC[C@H]4CC[C@@H](c5cccc(C(F)(F)F)c5)CC4)cc3)oc12 CHEMBL1771127 IC50 78.0 nM
CC(C)OC(=O)N1c2ccc(C(F)(F)F)cc2[C@@H](N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2nnn(C3CCNCC3)n2)C[C@H]1C CHEMBL2029494 IC50 78.0 nM
CC(C)OCc1cnc(N2CCC(c3nc4c(c(C5CCC(F)(F)CC5)c3[C@@H](F)c3ccc(C(F)(F)F)cc3)[C@@H](O)CC(C)(C)C4)CC2)nc1 CHEMBL3985476 IC50 78.0 nM
OC(CN(Cc1cccc(OC(F)(F)C(F)F)c1)c1cccc(Oc2ccc(F)c(F)c2)c1)C(F)(F)F CHEMBL235507 Log IC50 79.43 nM
CC(C)(C)c1cccc(Oc2cccc(N(Cc3cccc(OC(F)(F)C(F)F)c3)CC(O)C(F)(F)F)c2)c1 CHEMBL68856 IC50 80.0 nM
Cc1cc(Oc2cccc(N(Cc3cccc(OC(F)(F)C(F)F)c3)CC(O)C(F)(F)F)c2)ccc1F CHEMBL69885 IC50 80.0 nM
CCc1cc(C)cc(Oc2cccc(N(Cc3cccc(OC(F)(F)C(F)F)c3)CC(O)C(F)(F)F)c2)c1 CHEMBL302306 IC50 80.0 nM
OC(CN(Cc1cccc(OC(F)(F)C(F)F)c1)c1cccc(Oc2ccc(Cl)c(Cl)c2)c1)C(F)(F)F CHEMBL302352 IC50 80.0 nM
Cc1ccc(Oc2cccc(N(Cc3cccc(OC(F)(F)C(F)F)c3)CC(O)C(F)(F)F)c2)cc1C CHEMBL419437 IC50 80.0 nM
CCCOc1ccc(Oc2cccc(N(Cc3cccc(OC(F)(F)C(F)F)c3)CC(O)C(F)(F)F)c2)cc1 CHEMBL71379 IC50 80.0 nM
CC(C)c1nc2c(c(C3CCCCC3)c1[C@@H](O)c1ccc(C(F)(F)F)cc1)[C@@H](O)CC(C)(C)C2 CHEMBL1080749 IC50 80.0 nM
CCC1CCC(c2cc(C(C)C)ccc2OC)=C(CN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ncc(-c3cnn(C)c3)cn2)C1 CHEMBL3976202 IC50 80.0 nM
Cc1cc(C(=O)O)ccc1-c1nc(C)c(-c2cnc(N3CCOCC3)nc2CN2C(=O)O[C@H](c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2C)s1 CHEMBL3925314 IC50 82.0 nM
COc1ncc(-c2cc(-c3ccc(C(=O)O)cc3C)ccc2OC)c(CN2C(=O)O[C@H](c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2C)n1 CHEMBL4878757 IC50 82.0 nM
COc1ccc(-c2ccc(C(=O)O)cc2)cc1-c1ccc(C(F)(F)F)cc1CN1C(=O)O[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C CHEMBL4858285 IC50 82.0 nM
Cc1cc(C#N)cc2nc(-c3ccc(NC(=O)COC4CCN(CC(=O)OC(C)(C)C)CC4)cc3)oc12 CHEMBL1642938 IC50 83.0 nM
CC1(C)Cc2nc(C3CCN(c4ncccn4)CC3)c([C@@H](F)c3ccc(C(F)(F)F)cc3)c(C3CCC(F)(F)CC3)c2[C@@H](O)C1 CHEMBL3969568 IC50 83.0 nM
CCC(C)(C)OC(=O)N1CCC(OCC(=O)Nc2ccc(-c3nc4cc(C#N)cc(C)c4o3)cc2)CC1 CHEMBL1642935 IC50 84.0 nM
CC(C)c1cc(C#N)cc2nc(-c3ccc(C(=O)NC[C@H]4CC[C@H](c5cc(C(F)(F)F)cc(C(F)(F)F)c5)CC4)cc3)oc12 CHEMBL1771132 IC50 84.0 nM
O[C@H](CN1C[C@](Cc2cccc(OC(F)(F)F)c2)(c2cccc(OC(F)(F)F)c2)c2ccccc21)C(F)(F)F CHEMBL3804890 IC50 84.0 nM
COc1ncc(-c2ccc(C(=O)O)cc2C)cc1-c1cc(C(F)(F)F)c(OC)nc1CN1C(=O)O[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C CHEMBL4864315 IC50 84.0 nM
COc1cc(F)c(C(C)C)cc1-c1ccc(C(F)(F)F)cc1[C@@H]1CC[C@H]2[C@@H](c3cc(C(F)(F)F)cc(C(F)(F)F)c3)OC(=O)N12 CHEMBL3657471 IC50 84.92 nM
Cc1cc(Cl)ccc1OCC(=O)Nc1ccc(-c2nc3cc(C#N)ccc3o2)cc1 CHEMBL258793 IC50 85.0 nM
Cc1cc(C)c2oc(-c3ccc(NC(=O)COc4ccc(C)c5c4CCC5)cc3)nc2c1 CHEMBL409693 IC50 85.0 nM
C=CC[C@](NC(=O)NC1CCCC1)(c1cc(F)cc(C(F)(F)F)c1)c1ccc(Cl)cn1 CHEMBL2165689 IC50 85.0 nM
COc1ncc(-c2ccc(C(=O)O)cc2C)cc1-c1ccc(C(F)(F)F)cc1[C@@H]1CC[C@H]2[C@@H](c3cc(C)cc(C(F)(F)F)c3)OC(=O)N12 CHEMBL3657520 IC50 85.0 nM
O=C(NC1CCCC1)N[C@@](Cc1ccc(F)cc1)(c1cc(F)cc(C(F)(F)F)c1)c1ccc(Cl)cn1 CHEMBL2165688 IC50 87.0 nM
COc1ccc(-c2ccc(C(=O)O)cc2C)cc1-c1c(C)cc(C(F)(F)F)cc1[C@@H]1CC[C@H]2[C@@H](c3cc(C(F)(F)F)cc(C(F)(F)F)c3)OC(=O)N12 CHEMBL3657526 IC50 87.0 nM
Cc1ccccc1OCC(=O)Nc1ccc(-c2nc3cc(Cl)cc(Cl)c3o2)cc1 CHEMBL260326 IC50 88.0 nM
C[C@H](O)CN1c2cccc(-c3cccc(OC(F)(F)F)c3)c2OC[C@@H]1c1cccc(OC(F)(F)C(F)F)c1 CHEMBL597508 IC50 88.0 nM
Cc1noc(-c2cnc(N3CCC(c4nc5c(c(C6CCC(F)(F)CC6)c4[C@@H](F)c4ccc(C(F)(F)F)cc4)[C@@H](O)CC(C)(C)C5)CC3)nc2)n1 CHEMBL3910062 IC50 88.0 nM
COc1ccc([C@H]2OC(=O)N[C@H]2C)cc1-c1ccc(C(F)(F)F)cc1[C@@H]1CC[C@H]2[C@@H](c3cc(C(F)(F)F)cc(C(F)(F)F)c3)OC(=O)N12 CHEMBL3657538 IC50 89.0 nM
OC(CN(Cc1cccc(OC(F)(F)C(F)F)c1)c1cccc(OCc2ccccc2CC(F)(F)F)c1)C(F)(F)F CHEMBL237163 Log IC50 89.13 nM
OC(CN(Cc1cccc(OC(F)(F)C(F)F)c1)c1cccc(Oc2ccc3c(c2)CCCC3)c1)C(F)(F)F CHEMBL308423 IC50 90.0 nM
Cc1cccc(Oc2cccc(N(Cc3cccc(OC(F)(F)C(F)F)c3)CC(O)C(F)(F)F)c2)c1 CHEMBL66503 IC50 90.0 nM
OC(CN(Cc1cccc(OC(F)(F)C(F)F)c1)c1cccc(OCc2cccc(C(F)(F)F)c2)c1)C(F)(F)F CHEMBL68722 IC50 90.0 nM
CC1(C)Cc2nc(C3CCCC3)c(C(=O)c3ccc(C(F)(F)F)cc3)c(C3CCCC3)c2[C@@H](O)C1 CHEMBL1087411 IC50 90.0 nM
O=C(NC1CCCCC1)N[C@@](Cc1ccccc1)(c1cc(F)cc(C(F)(F)F)c1)c1ccc(Cl)cn1 CHEMBL2152160 IC50 90.0 nM
Fc1cc(OC(F)(F)C(F)F)cc([C@@](Cc2ccccc2)(Nc2nc3ccccc3[nH]2)c2ccc(Cl)cn2)c1 CHEMBL3116156 IC50 90.0 nM
CC(C)c1nc2c(c3c1[C@@H](c1ccc(C(F)(F)F)nc1)OC31CCOCC1)[C@@H](O)CC1(CC1)C2 CHEMBL3984598 IC50 90.0 nM
Cc1cc(C#N)cc2nc(-c3ccc(NC(=O)COC4CCN(C(=O)OC(C)(C)C)CC4)cc3)oc12 CHEMBL1642930 IC50 91.0 nM
Cc1ccccc1OCC(=O)Nc1ccc(-c2nc3cc(C(F)(F)F)cc(C(F)(F)F)c3o2)cc1 CHEMBL260324 IC50 92.0 nM
N#Cc1ccc2oc(-c3ccc(NC(=O)COC4CCCCCC4)cc3)nc2c1 CHEMBL1642924 IC50 92.0 nM
CC[C@@H]1C[C@H](N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ncc(-c3cnn(C)c3)cn2)CN1C(=O)C1CCCCC1 CHEMBL3685763 IC50 92.0 nM
CCOc1cnc(N2CCC(c3nc4c(c(C5CCC(F)(F)CC5)c3[C@@H](F)c3ccc(C(F)(F)F)cc3)[C@@H](O)CC(C)(C)C4)CC2)nc1 CHEMBL3960263 IC50 92.0 nM
COc1ncc(CCC(=O)O)cc1-c1cnc(N2CC(F)C2)nc1CN1C(=O)O[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C CHEMBL3923209 IC50 92.0 nM
COc1ccc(C(C)C)cc1-c1ccc(C(F)(F)F)cc1CN1C[C@@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)OC1=O CHEMBL1800801 IC50 93.0 nM
O[C@@H](CN1c2cccc(-c3cc(F)c(F)c(F)c3)c2OC[C@@H]1c1cccc(OC(F)(F)F)c1)C(F)(F)F CHEMBL602697 IC50 94.0 nM
N#Cc1ccc2oc(-c3ccc(NC(=O)COC(C(F)(F)F)C(F)(F)F)cc3)nc2c1 CHEMBL590629 IC50 94.0 nM
O[C@H](CN1CC(Cc2cccc(OC(F)(F)F)c2)(c2cccc(OC(F)(F)C(F)F)c2)c2ccccc21)C(F)(F)F CHEMBL3806139 IC50 94.0 nM
COc1ccc(-c2ccc(C(=O)O)cc2C)cc1-c1cnc(N2CC(F)C2)nc1CN1C(=O)O[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C CHEMBL4872545 IC50 94.0 nM
COc1cc(F)c(C(C)C)cc1-c1ccc(C(F)(F)F)cc1[C@@H]1CC[C@H]2[C@@H](c3cc(C(F)(F)F)cc(C(F)(F)F)c3)NC(=O)N12 CHEMBL4756749 IC50 95.0 nM
COc1cc(F)c(-c2ccc(-c3nnc(N)o3)cc2C)cc1-c1ccc(C(F)(F)F)cc1[C@@H]1CC[C@H]2[C@@H](c3cc(C)cc(C(F)(F)F)c3)OC(=O)N12 CHEMBL3657543 IC50 95.01 nM
Cc1cc(C)c2oc(-c3ccc(NC(=O)COc4ccc(Cl)cc4C)cc3)nc2c1 CHEMBL261274 IC50 96.0 nM
OC(CN1c2cccc(-c3cccc(C(F)(F)F)c3)c2CCC1c1cccc(OC(F)(F)C(F)F)c1)C(F)(F)F CHEMBL491866 IC50 96.0 nM
CC(C)c1nc2c(c3c1[C@@H](c1ccc(C(F)(F)F)cn1)OC31CCCC1)[C@@H](O)CC(C)(C)C2 CHEMBL3360272 IC50 96.0 nM
COc1ccc([C@H]2C[C@H](C(=O)O)C2)cc1-c1ccc(C(F)(F)F)cc1[C@@H]1CC[C@H]2[C@@H](c3cc(C(F)(F)F)cc(C(F)(F)F)c3)OC(=O)N12 CHEMBL3933320 IC50 96.54 nM
Cc1ccccc1OCC(=O)Nc1ccc(-c2nc3cc(Cl)cc(Br)c3o2)cc1 CHEMBL260201 IC50 97.0 nM
CC(C)Oc1cnc(N2CCC(c3nc4c(c(C5CCC(F)(F)CC5)c3[C@@H](F)c3ccc(C(F)(F)F)cc3)[C@@H](O)CC(C)(C)C4)CC2)nc1 CHEMBL3965343 IC50 97.0 nM
COc1ccc(-c2ccc(C(=O)O)cc2C)cc1-c1cnc(N2CCCC2)nc1CN1C(=O)O[C@H](c2cc(C(F)(F)F)cc(C(F)(F)F)c2)[C@@H]1C CHEMBL4850473 IC50 97.0 nM
CC[C@@H]1C[C@H](N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2nnn(C)n2)c2nc(N)ccc2N1C(=O)OC(C)C CHEMBL2017204 IC50 98.0 nM
Cc1cc(C#N)cc2nc(-c3ccc(NC(=O)COC4CCN(C(=O)OC(C)C)CC4)cc3)oc12 CHEMBL1642933 IC50 99.0 nM
COc1ccc(N2CCN(CC(=O)Nc3ccc(-c4nc5cc(C#N)cc(C)c5o4)cc3)CC2)cc1 CHEMBL1643155 IC50 99.0 nM
CC(C)COc1cnc(N2CCC(c3nc4c(c(C5CCC(F)(F)CC5)c3[C@@H](F)c3ccc(C(F)(F)F)cc3)[C@@H](O)CC(C)(C)C4)CC2)nc1 CHEMBL3894310 IC50 99.0 nM