CCN[C@H](CC(=O)N1CCN(c2nc(N)c3cc(OC)c(OC)c(F)c3n2)CC1)c1ccc(C#N)cc1 CHEMBL4114217 IC50 1.0 nM
CCO[C@H]1CCN(Cc2c(C3CC3)cc(C)c3[nH]ccc23)[C@H](c2ccc(C(=O)O)cc2)C1 CHEMBL4639592 IC50 6.0 nM
CCO[C@H]1CCN(Cc2c(OC)cc(C)c3[nH]ccc23)[C@H](c2ccc(C(=O)O)cc2)C1 CHEMBL4594448 Kd 7.9 nM
CO[C@H]1CCN(Cc2c(C3CC3)cc(C)c3[nH]ccc23)[C@H](c2ccc(C(=O)O)cc2)C1 CHEMBL4641109 IC50 18.0 nM
COc1cc(C)c2[nH]ccc2c1CN1CC[C@H](OC)C[C@H]1c1ccc(C(=O)O)cc1 CHEMBL4632794 IC50 18.0 nM
CCO[C@H]1CCN(Cc2c(C)cc(C)c3[nH]ccc23)[C@H](c2ccc(C(=O)O)cc2)C1 CHEMBL4644208 IC50 18.0 nM
CNC(c1nc2ccc(C#N)cc2[nH]1)(c1c(C)cc(C)cc1OC)C(F)(F)F CHEMBL4247942 IC50 23.0 nM
CO[C@H]1CCN(Cc2c(C)cc(C)c3[nH]ccc23)[C@H](c2ccc(C(=O)O)cc2)C1 CHEMBL4646504 IC50 24.0 nM
COc1cc(C)c2[nH]ccc2c1C(C)(OC)c1nc2cc(C#N)cnc2[nH]1 CHEMBL3931270 IC50 30.0 nM
CNC(c1nc2cc(C#N)cnc2[nH]1)(c1c(OC)cc(C)c2[nH]ccc12)C(F)(F)F CHEMBL3894205 IC50 30.0 nM
COc1cc(C)c2[nH]ccc2c1C(C)(C)c1nc2cc(C#N)cnc2[nH]1 CHEMBL3927308 IC50 30.0 nM
Cc1cc(C)c2[nH]ccc2c1CN1CCCCC1c1ccc(C(=O)O)cc1 CHEMBL4644994 IC50 33.0 nM
COc1cc(C)c2[nH]ccc2c1C(C)(N)c1nc2cc(C#N)cnc2[nH]1 CHEMBL3954424 IC50 40.0 nM
COc1cc(C)c2[nH]ccc2c1C(C)(O)c1nc2cc(C#N)cnc2[nH]1 CHEMBL3908792 IC50 50.0 nM
Cc1cc(C2CC2)c(C(C)(O)c2nc3cc(C#N)cnc3[nH]2)c2cc[nH]c12 CHEMBL3913748 IC50 60.0 nM
COc1cc(C)c2[nH]ccc2c1C(O)c1nc2ncc(C#N)cc2[nH]1 CHEMBL3945639 IC50 90.0 nM
Cc1cc(C2CC2)c(C(N)(c2nc3cc(C#N)cnc3[nH]2)C(F)(F)F)c2cc[nH]c12 CHEMBL3958120 IC50 90.0 nM
CCc1cc(C)c2[nH]ccc2c1C(O)(c1nc2cc(C#N)cnc2[nH]1)C(F)(F)F CHEMBL3899277 IC50 100.0 nM
COc1cc(C)c2[nH]ccc2c1C(N)(c1nc2cc(C#N)cnc2[nH]1)C(F)(F)F CHEMBL3949381 IC50 140.0 nM
CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O CHEMBL1089597 IC50 250.0 nM
CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NC=O CHEMBL4244153 IC50 250.0 nM
CNC(C)(c1nc2cc(C#N)cnc2[nH]1)c1c(OC)cc(C)c2[nH]ccc12 CHEMBL3904754 IC50 295.0 nM
Cc1cc(C2CC2)c(C(O)c2nc3cc(C#N)cnc3[nH]2)c2cc[nH]c12 CHEMBL3910541 IC50 460.0 nM
CCc1cc(C)c2[nH]ccc2c1C(C)(NC)c1nc2cc(C#N)cnc2[nH]1 CHEMBL3926271 IC50 540.0 nM
CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O CHEMBL1089595 IC50 600.0 nM
Cc1cc(C)c2[nH]ccc2c1CN1CCCCC1c1ccc(C(N)=O)cc1 CHEMBL4647418 IC50 710.0 nM
COC1CCN(Cc2c(C)cc(C)c3[nH]ccc23)C(c2ccccc2)C1 CHEMBL4633437 IC50 720.0 nM