CNC(=O)c1ccccc1Sc1ccc2c(/C=C/c3ccccn3)n[nH]c2c1 CHEMBL1289926 Ki 0.0 nM
CCn1nc(C)cc1C(=O)Nc1cccc(C(=O)c2ccc3c(/C=C/c4ccccn4)n[nH]c3c2)c1 CHEMBL3915607 Ki 0.0 nM
Cc1cc(C(=O)Nc2cccc(C(=O)c3ccc4c(/C=C/c5ccccn5)n[nH]c4c3)c2)n(C)n1 CHEMBL3891895 Ki 0.0 nM
CCn1nc(C)cc1C(=O)Nc1cccc(Oc2ccc3c(/C=C/c4ccccn4)n[nH]c3c2)c1 CHEMBL3953227 Ki 0.0 nM
CC(C)ONC(=O)c1ccccc1Sc1ccc2c(/C=C/c3ccccn3)n[nH]c2c1 CHEMBL3955019 Ki 0.0 nM
CCn1nc(C)cc1C(=O)Nc1cc(C(=O)c2ccc3c(/C=C/c4ccccn4)n[nH]c3c2)ccc1C CHEMBL3930485 Ki 0.0 nM
CCCn1nc(C)cc1C(=O)Nc1cccc(C(=O)c2ccc3c(/C=C/c4ccccn4)n[nH]c3c2)c1 CHEMBL3901827 Ki 0.0 nM
C#CCNC(=O)c1ccccc1Sc1ccc2c(/C=C/c3ccccn3)n[nH]c2c1 CHEMBL3965277 Ki 0.0 nM
CCONC(=O)c1ccccc1Sc1ccc2c(/C=C/c3ccccn3)n[nH]c2c1 CHEMBL3963146 Ki 0.0 nM
CCn1nc(C)cc1C(=O)Nc1cc(Nc2ccc3c(/C=C/c4ccccn4)n[nH]c3c2)c(F)cc1C CHEMBL3982880 Ki 0.0 nM
C=CCn1nc(C)cc1C(=O)Nc1cccc(C(=O)c2ccc3c(/C=C/c4ccccn4)n[nH]c3c2)c1 CHEMBL3904168 Ki 0.0 nM
CS(=O)(=O)N1CCN(c2ccnc(Nc3ncc(-c4cncc(C(=O)NCCN)c4)s3)c2)CC1 CHEMBL2011352 IC50 0.03 nM
CC(=O)N1CCN(c2ccnc(Nc3ncc(-c4cncc(C(=O)NCCN)c4)s3)c2)CC1 CHEMBL2011353 IC50 0.03 nM
COc1cc(CCNCc2ccc(N3CCNCC3)cc2)c(Cl)cc1NC(=O)Nc1cnc(C#N)cn1 CHEMBL3694397 IC50 0.03 nM
NCCNC(=O)c1cncc(-c2cnc(Nc3cc(N4CCOCC4)ccn3)s2)c1 CHEMBL2010809 IC50 0.05 nM
NCNC(=O)c1cncc(-c2cnc(Nc3cc(N4CCC(F)(F)CC4)ccn3)s2)c1 CHEMBL2013170 IC50 0.05 nM
NCCNC(=O)c1cncc(-c2cnc(Nc3cc(N4CCNCC4)ccn3)s2)c1 CHEMBL2011350 IC50 0.05 nM
NCCNC(=O)c1cncc(-c2cnc(Nc3cc(N4CCC(F)(F)CC4)ccn3)s2)c1 CHEMBL2011354 IC50 0.05 nM
NCNC(=O)c1cncc(-c2cnc(Nc3cc(N4CCC(F)CC4)ccn3)s2)c1 CHEMBL2013169 IC50 0.07 nM
COc1cc2c(cc1OC[C@H](O)CO)Cc1c-2n[nH]c1-c1ccc(-c2ccc(O)cc2)cc1 CHEMBL248012 IC50 0.1 nM
COc1cc2c(cc1OC[C@@H](O)CO)Cc1c-2n[nH]c1-c1ccc(-c2ccc(O)cc2)cc1 CHEMBL247646 IC50 0.1 nM
COc1cc2c(cc1OC(CO)CO)Cc1c-2n[nH]c1-c1ccc(-c2ccc(O)cc2)cc1 CHEMBL248194 pKi 0.1 nM
Cc1cc2n[nH]c(=O)n2c2cc(-c3ccc[nH]3)ccc12 CHEMBL1223526 IC50 0.1 nM
NCc1nn[nH]c1-c1ccc2c(-c3cc4cc(CN5CCC(F)CC5)ccc4[nH]3)n[nH]c2c1 CHEMBL219789 IC50 0.11 nM
COc1cc(CCN[C@@H](C)c2ccc(N3CCNCC3)cc2)c(Cl)cc1NC(=O)Nc1cnc(C#N)cn1 CHEMBL3694385 IC50 0.13 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL388978 IC50 0.142 nM
Oc1ccc(-c2ccc(-c3cc(Nc4ccc(CN5CCCC5)cc4)n[nH]3)cc2)c(O)c1 CHEMBL241231 Ki 0.18 nM
CN(C)Cc1ccc(Nc2cc(-c3ccc(-c4ccc(O)cc4O)cc3)[nH]n2)cc1 CHEMBL392692 Ki 0.19 nM
CCC(C)NCc1ccc(Nc2cc(-c3ccc(-c4ccc(O)cc4O)cc3)[nH]n2)cn1 CHEMBL392900 Ki 0.2 nM
COc1cc2c(cc1OCCCN1CCN(C)CC1)-c1n[nH]c(-c3ccc(-c4ccc(O)cc4)cc3)c1C2 CHEMBL248036 IC50 0.2 nM
COc1cc2c(cc1OC1CCOCC1)Cc1c-2n[nH]c1-c1ccc(-c2ccc(O)cc2)cc1 CHEMBL247825 IC50 0.2 nM
Cn1cc(C2=Nc3cc(NC(=O)C(N)C4CCCCC4)cc4c3C2=CNNC4=O)cn1 CHEMBL3545137 Kd apparent 0.2 nM
COc1cc2c(cc1CNCCN1CCCC1)Cc1c(-c3ccc(-c4ccc(O)cc4)cc3)n[nH]c1-2 CHEMBL232810 IC50 0.21 nM
COc1cc(CCNCc2ccc3c(c2)OCO3)c(Cl)cc1NC(=O)Nc1cnc(C#N)cn1 CHEMBL3694387 IC50 0.23 nM
COc1cc2c(cc1C(=O)N[C@H]1CC[C@H](O)CC1)Cc1c(-c3ccc(-c4ccc(O)cc4)cc3)n[nH]c1-2 CHEMBL428196 IC50 0.24 nM
COc1cc2c(cc1C(=O)N1CCC(O)CC1)Cc1c(-c3ccc(-c4ccc(O)cc4)cc3)n[nH]c1-2 CHEMBL234868 IC50 0.24 nM
COc1cc(-c2ccc3c(-c4cc5cc(CN6CCCCC6)ccc5[nH]4)n[nH]c3c2)ccc1O CHEMBL374424 IC50 0.25 nM
COc1cc2c(cc1OC)-c1n[nH]c(-c3ccc(-c4ccc(O)cc4)nc3)c1C2 CHEMBL245802 pKi 0.2512 nM
NCCC(=O)c1cncc(-c2cnc(Nc3cc(N4CCOCC4)ccn3)s2)c1 CHEMBL2011359 IC50 0.27 nM
COc1ccc(CNCCc2cc(OC)c(NC(=O)Nc3cnc(C#N)cn3)cc2Cl)cc1 CHEMBL3694382 IC50 0.28 nM
OCc1nn[nH]c1-c1ccc2c(-c3cc4cc(CN5CCC(F)CC5)ccc4[nH]3)n[nH]c2c1 CHEMBL219788 IC50 0.3 nM
OCc1n[nH]nc1-c1ccc2c(-c3cc4cc(CN5CCCCC5)ccc4[nH]3)n[nH]c2c1 CHEMBL374713 IC50 0.3 nM
Oc1ccc(-c2ccc(-c3cc(Nc4ccc(CN5CCCCC5)nc4)n[nH]3)cc2)c(O)c1 CHEMBL241233 Ki 0.3 nM
NCCCc1cc2c(-c3ccc(O)cc3)c[nH]c(=O)c2c2cc(-c3cn[nH]c3)ccc12 CHEMBL249443 IC50 0.3 nM
N#Cc1ncc2nc1OCCCCOc1cc(O)c(Cl)cc1NC(=O)N2 CHEMBL400805 IC50 0.3 nM
N#Cc1ncc2nc1OC/C=C\COc1cc(OCCCN3CCOCC3)c(Cl)cc1NC(=O)N2 CHEMBL400397 IC50 0.3 nM
N#Cc1ncc2nc1OC/C=C\COc1cc(O)c(Cl)cc1NC(=O)N2 CHEMBL399916 IC50 0.3 nM
N#Cc1ncc2nc1OC/C=C\COc1cc(N)c(Cl)cc1NC(=O)N2 CHEMBL249363 IC50 0.3 nM
COc1cc(-c2ccc3c(c2)NC(=O)/C3=C\c2cc(C(=O)NCCN3CCCC3)c(C)[se]2)ccc1O CHEMBL1223184 IC50 0.3 nM
NCCNC(=O)c1cncc(-c2cnc(Nc3ncccc3Cl)s2)c1 CHEMBL2013161 IC50 0.3 nM
O=c1[nH]c2ccc(Cl)cc2c(N[C@@H]2CN3CCC2CC3)c1-c1nc2ccccc2[nH]1 CHEMBL377312 IC50 0.3 nM
Cn1cc(-c2cc3c(cn2)[nH]c2ncc(-c4ccc(CN5CCCCC5)cc4)cc23)cn1 CHEMBL3582227 IC50 0.31 nM
CC(C)Oc1cc(CCNCc2ccc(F)cc2)c(Cl)cc1NC(=O)Nc1cnc(C#N)cn1 CHEMBL3694379 IC50 0.32 nM
NC(=O)c1ccc2[nH]c(=O)c(-c3cc4cc(CN5CCCCC5)ccc4[nH]3)cc2c1 CHEMBL221448 IC50 0.34 nM
Cc1ccc2nc(O)c(-c3nc4ccccc4[nH]3)c(N[C@@H]3CN4CCC3CC4)c2c1 CHEMBL378967 IC50 0.35 nM
CC(C)NCc1ccc(Nc2cc(-c3ccc(-c4ccc(O)cc4O)cc3)[nH]n2)cc1 CHEMBL398606 Ki 0.36 nM
Oc1ccc(-c2ccc(-c3cc(Nc4ccc(CNC5CC5)cc4)n[nH]3)cc2)c(O)c1 CHEMBL241232 Ki 0.38 nM
COc1cc2c(cc1OC1CCOC1)Cc1c-2n[nH]c1-c1ccc(-c2ccc(O)cc2)cc1 CHEMBL248199 IC50 0.4 nM
CCN(CC)CCNC(=O)c1cc(/C=C2\C(=O)Nc3cc(-c4ccc(O)cc4)ccc32)[se]c1C CHEMBL1223408 IC50 0.4 nM
Cc1[se]c(/C=C2\C(=O)Nc3cc(-c4ccc(O)cc4)ccc32)cc1C(=O)NCCN1CCCC1 CHEMBL1223409 IC50 0.4 nM
Cc1cccnc1Nc1ncc(-c2cncc(C(=O)NCCN)c2)s1 CHEMBL2013162 IC50 0.4 nM
NCCNC(=O)c1cncc(-c2cnc(Nc3cc(CN4CCOCC4)ccn3)s2)c1 CHEMBL2011356 IC50 0.4 nM
CNc1nc(Nc2cnc(C#N)c(O[C@@H]3CCCNC3)c2)ncc1-c1cnn(C)c1 CHEMBL4577258 IC50 0.4 nM
CNc1nc(Nc2cnc(C#N)c(O[C@@H]3CCCNC3)c2)ncc1-c1cnn(C)c1 CHEMBL4448921 IC50 0.4 nM
COc1cc2c(cc1CNCCO)Cc1c(-c3ccc(-c4ccc(O)cc4)cc3)n[nH]c1-2 CHEMBL232809 IC50 0.43 nM
COc1cc(CCNCc2ccc(F)cc2)c(Br)cc1NC(=O)Nc1cnc(C#N)cn1 CHEMBL3694375 IC50 0.45 nM
COc1cc(CCNCc2ccc(N3CCN(C)CC3)cc2)c(Cl)cc1NC(=O)Nc1cnc(C#N)cn1 CHEMBL3694383 IC50 0.45 nM
c1ncc(-c2cc3c(cn2)[nH]c2ncc(-c4ccc(CN5CCCCC5)cc4)cc23)o1 CHEMBL3582223 IC50 0.46 nM
COc1cccc(CNCCc2cc(OC)c(NC(=O)Nc3cnc(C#N)cn3)cc2Cl)c1 CHEMBL3694381 IC50 0.47 nM
COc1ccccc1CNCCc1cc(OC)c(NC(=O)Nc2cnc(C#N)cn2)cc1Cl CHEMBL3694388 IC50 0.48 nM
Cn1cc(-c2[nH]c3cc(NC(=O)[C@H](N)C4CCCCC4)cc4c3c2C=NNC4=O)cn1 CHEMBL3990456 Ki 0.49 nM
Oc1nc2ccc(Cl)cc2c(N[C@H]2CCNC2)c1-c1nc2ccccc2[nH]1 CHEMBL209982 IC50 0.5 nM
O=C(Nc1ccc(O)cc1O)c1ccc2c(-c3nc4ccccc4[nH]3)n[nH]c2c1 CHEMBL239737 Ki 0.5 nM
NCCc1cc2cc[nH]c(=O)c2c2cc(-c3ccc[nH]3)ccc12 CHEMBL249429 IC50 0.5 nM
COc1cc(-c2ccc3c(c2)NC(=O)/C3=C\c2cc(C(=O)NCCN(C)C)c(C)[se]2)ccc1O CHEMBL1223182 IC50 0.5 nM
COc1cc(-c2ccc3c(c2)NC(=O)/C3=C\c2cc(C(=O)NCCCn3ccnc3)c(C)[se]2)ccc1O CHEMBL1223263 IC50 0.5 nM
Cc1[se]c(/C=C2\C(=O)Nc3cc(-c4ccc(O)cc4)ccc32)cc1C(=O)NCCCn1ccnc1 CHEMBL1223478 IC50 0.5 nM
CNc1nc(Nc2cnc(C#N)c(OC3CCNCC3)c2)ncc1-c1cnn(C)c1 CHEMBL4444269 IC50 0.5 nM
COC(=O)c1cnc(Nc2cnc(C#N)cn2)cc1NC1C[C@H]2CC[C@@H](C1)N2C CHEMBL4753307 IC50 0.5 nM
Cc1cnc(-c2cnc(Nc3cnc(C#N)cn3)cc2NC[C@H]2CNCCO2)s1 CHEMBL4742233 IC50 0.5 nM
CC(C)(O)C#Cc1cnc(Nc2cnc(C#N)cn2)cc1NC[C@H]1CNCCO1 CHEMBL4752718 IC50 0.5 nM
COc1cc2c(cc1OCCN1CCCCC1)-c1[nH]nc(-c3ccc(-c4ccc(O)cc4)cc3)c1C2 CHEMBL550479 pKi 0.5012 nM
COc1cc2c(cc1CN1CCN(C)CC1)Cc1c(-c3ccc(-c4ccc(O)cc4)cc3)n[nH]c1-2 CHEMBL393993 IC50 0.51 nM
COc1cc2c(cc1C(=O)N1CCOCC1)Cc1c(-c3ccc(-c4ccc(O)cc4)cc3)n[nH]c1-2 CHEMBL232808 IC50 0.55 nM
COc1cc2c(cc1CN[C@H]1CC[C@H](O)CC1)Cc1c(-c3ccc(-c4ccc(O)cc4)cc3)n[nH]c1-2 CHEMBL234871 IC50 0.56 nM
COc1ccc([C@H](C)NCCc2cc(OC)c(NC(=O)Nc3cnc(C#N)cn3)cc2Cl)cc1 CHEMBL3694386 IC50 0.56 nM
COc1cccc(OCCCN)c1-c1cc(Nc2cnc(C#N)cn2)n[nH]1 CHEMBL3544911 IC50 0.56 nM
COc1cc2c(cc1OCCO)Nc1cc(-c3ccc([N+](=O)[O-])c(OC)c3)ccc1C(=O)N2 CHEMBL270181 IC50 0.58 nM
CCN1CCCC(Oc2cc3c(cc2OC)Cc2c-3n[nH]c2-c2ccc(-c3ccc(O)cc3)cc2)C1 CHEMBL400740 IC50 0.6 nM
COc1cc2c(cc1OCC(C)CN(C)C)-c1n[nH]c(-c3ccc(-c4ccc(O)cc4)cc3)c1C2 CHEMBL245601 IC50 0.6 nM
NCCc1cc2cc[nH]c(=O)c2c2cc(-c3ccc(CN4CCOCC4)cc3)ccc12 CHEMBL249237 IC50 0.6 nM
COc1cc2c(cc1OC)Nc1cc(-c3ccc([N+](=O)[O-])c(OC)c3)ccc1C(=O)N2 CHEMBL404189 IC50 0.6 nM
CCN(CC)CCNC(=O)c1cc(/C=C2\C(=O)Nc3cc(-c4ccc(O)c(OC)c4)ccc32)[se]c1C CHEMBL1223183 IC50 0.6 nM
Cc1[se]c(/C=C2\C(=O)Nc3cc(-c4ccc(O)cc4)ccc32)cc1C(=O)NCCN(C)C CHEMBL1223407 IC50 0.6 nM
Cn1cc(-c2ccc3c(c2)Nc2ccc(CCOc4ccc(N5CCOCC5)cc4)cc2NC3=O)c2ccncc21 CHEMBL538671 pKi 0.631 nM
O=c1[nH]c2ccc(-c3cnsc3)cc2cc1-c1cc2cc(CN3CCCCC3)ccc2[nH]1 CHEMBL221554 IC50 0.64 nM
O=c1[nH]c2ccc(-c3cn[nH]c3)cc2cc1-c1cc2cc(CN3CCCCC3)ccc2[nH]1 CHEMBL374662 IC50 0.65 nM
Cc1[nH]nc2c1c(=O)n(CCCN)c1cc(C3CCCCC3)c(C3CCCCC3)cc21 CHEMBL250481 IC50 0.66 nM
NCC1CCN(Cc2ccc3[nH]c(-c4cc5cc(C(N)=O)ccc5[nH]c4=O)cc3c2)CC1 CHEMBL218489 IC50 0.7 nM
COc1cc2c(cc1OC[C@H]1CC=CCC1)Cc1c-2n[nH]c1-c1ccc(-c2ccc(O)cc2)cc1 CHEMBL247826 IC50 0.7 nM
COc1cc2c(cc1OCCCN(C)C)Cc1c-2n[nH]c1-c1ccc(-c2ccc(O)cc2)cc1 CHEMBL248002 IC50 0.7 nM
COc1cc2c(cc1OCCCCO)Nc1cc(-c3ccc([N+](=O)[O-])c(OC)c3)ccc1C(=O)N2 CHEMBL256193 IC50 0.7 nM
COc1cccc([C@H](C)NCCc2cc(OC)c(NC(=O)Nc3cnc(C#N)cn3)cc2Cl)c1 CHEMBL3694398 IC50 0.73 nM
O=c1[nH]c2ccc(-n3ccnn3)cc2cc1-c1cc2cc(CN3CCCCC3)ccc2[nH]1 CHEMBL221287 IC50 0.74 nM
O=C(CNCCO)Nc1ccc2c(c1)Cc1c(-c3ccc(-c4ccc(O)cc4)cc3)n[nH]c1-2 CHEMBL234656 IC50 0.74 nM
N#Cc1ccc(-c2n[nH]c3c2Cc2ccc(OCCCCN4CCOCC4)cc2-3)cn1 CHEMBL398951 IC50 0.75 nM
CCN1CCc2sc(-c3cnc4[nH]c5cnc(C#N)cc5c4c3)cc2C1 CHEMBL3582216 IC50 0.78 nM
Oc1ccc(-c2ccc(-c3cc(Nc4ccc(CNCC5CC5)nc4)n[nH]3)cc2)c(O)c1 CHEMBL241447 Ki 0.8 nM
COc1cc2c(cc1OCCC1CCCN1C)-c1n[nH]c(-c3ccc(-c4ccc(O)cc4)cc3)c1C2 CHEMBL247649 IC50 0.8 nM
COc1cc2c(cc1OCCN(C)C)-c1n[nH]c(-c3ccc(-c4ccc(O)cc4)cc3)c1C2 CHEMBL245600 IC50 0.8 nM
COc1cc2c(cc1OCC1CCOC1)Cc1c-2n[nH]c1-c1ccc(-c2ccc(O)cc2)cc1 CHEMBL248198 IC50 0.8 nM
COc1cc2c(cc1OCCN1CCCC1)Cc1c-2n[nH]c1-c1ccc(-c2ccc(O)cc2)cc1 CHEMBL248190 IC50 0.8 nM
COc1cc2c(cc1OC)-c1[nH]nc(-c3ccc(C#N)nc3)c1C2 CHEMBL398750 IC50 0.8 nM
NCCCc1cc2c(-c3ccccc3Cl)c[nH]c(=O)c2c2cc(-c3cn[nH]c3)ccc12 CHEMBL250035 IC50 0.8 nM
Cc1[se]c(/C=C2\C(=O)Nc3cc(-c4ccc(O)cc4)ccc32)cc1C(=O)NCCN1CCCCO1 CHEMBL1223477 IC50 0.8 nM
O=c1[nH]c2ccc(-c3cn[nH]c3)cc2cc1-c1cc2cc(CN3CCOCC3)ccc2[nH]1 CHEMBL220601 IC50 0.83 nM
COc1cc2c(cc1C(=O)NCCN1CCCC1)Cc1c(-c3ccc(-c4ccc(O)cc4)cc3)n[nH]c1-2 CHEMBL234869 IC50 0.83 nM
CNc1nc(Nc2cnc(C#N)c(OC3CCCNC3)c2)ncc1-c1cnn(C)c1 CHEMBL4451583 IC50 0.89 nM
COc1cc2c(cc1O)Nc1cc(-c3ccc([N+](=O)[O-])c(OC)c3)ccc1C(=O)N2 CHEMBL410195 IC50 0.9 nM
Cn1cc(-c2cnc(Nc3cnc(C#N)cn3)cc2NC[C@H]2CNCCO2)cn1 CHEMBL4790962 IC50 0.9 nM
N#Cc1ccc(-c2n[nH]c3c2Cc2ccc(OCCCN4CCCOCC4)cc2-3)cn1 CHEMBL248719 IC50 0.92 nM
c1cncc(-c2cc3c(cn2)[nH]c2ncc(-c4ccc(CN5CCCCC5)cc4)cc23)c1 CHEMBL3582228 IC50 0.95 nM
c1nnc(-c2cc3c(cn2)[nH]c2ncc(-c4ccc(CN5CCCCC5)cc4)cc23)o1 CHEMBL3582225 IC50 0.95 nM
COc1cc2c(cc1OCCCN)Nc1cc(-c3ccc([N+](=O)[O-])c(OC)c3)ccc1C(=O)N2 CHEMBL256192 IC50 0.98 nM
O=c1[nH]c2ccc(-c3cn[nH]c3)cc2cc1-c1cc2cc(CN3CCC(F)CC3)ccc2[nH]1 CHEMBL220956 IC50 1.0 nM
CN(C)CC(=O)Nc1cc2c(cc1Cl)NC(=O)Nc1cnc(C#N)c(n1)OCCCCCO2 CHEMBL220473 IC50 1.0 nM
CN(C)CCOc1cc2c(cc1Cl)NC(=O)Nc1cnc(C#N)c(n1)OCCCCCO2 CHEMBL219875 IC50 1.0 nM
N#Cc1ncc2nc1OCCCCCOc1cc(OCCCN)c(Cl)cc1NC(=O)N2 CHEMBL373732 IC50 1.0 nM
COc1cc2c(cc1O)Cc1c-2n[nH]c1-c1ccc(-c2ccc(O)cc2)cc1 CHEMBL400286 IC50 1.0 nM
COc1cc2c(cc1OCCN1CCCCC1)Cc1c-2n[nH]c1-c1ccc(-c2ccc(O)cc2)cc1 CHEMBL248008 IC50 1.0 nM
C[C@@H]1CN(CCCOc2ccc3c(c2)-c2[nH]nc(-c4ccc(C#N)nc4)c2C3)C[C@H](C)O1 CHEMBL401177 IC50 1.0 nM
N#Cc1ccc(-c2n[nH]c3c2Cc2ccc(OCCCC4CCNCC4)cc2-3)cn1 CHEMBL248910 IC50 1.0 nM
COc1cc2c(cc1OC1CCOCC1)Cc1c-2n[nH]c1-c1ccc(C#N)cc1 CHEMBL396372 IC50 1.0 nM
NCCCc1cc2c(-c3cccc(O)c3)c[nH]c(=O)c2c2cc(-c3cn[nH]c3)ccc12 CHEMBL249441 IC50 1.0 nM
N#Cc1ncc2nc1OCCCCOc1cc(OC(=O)N3CCC(N4CCCCC4)CC3)c(Cl)cc1NC(=O)N2 CHEMBL401196 IC50 1.0 nM
N#Cc1ncc2nc1OCCCCOc1cc(OCCCN3CCOCC3)c(Cl)cc1NC(=O)N2 CHEMBL249364 IC50 1.0 nM
N#Cc1ncc2nc1OCCCCOc1cc(OCCCO)c(Cl)cc1NC(=O)N2 CHEMBL249156 IC50 1.0 nM
N#Cc1ncc2nc1OCCCCOc1cc(N)c(Cl)cc1NC(=O)N2 CHEMBL248555 IC50 1.0 nM
N#Cc1ncc2nc1OC/C=C\COc1cc(OC(=O)N3CCC(N4CCCCC4)CC3)c(Cl)cc1NC(=O)N2 CHEMBL248554 IC50 1.0 nM
N#Cc1ncc2nc1OC/C=C\COc1cc(OCCN3CCOCC3)c(Cl)cc1NC(=O)N2 CHEMBL248553 IC50 1.0 nM
N#Cc1ncc2nc1OC/C=C\COc1cc(OCCO)c(Cl)cc1NC(=O)N2 CHEMBL401337 IC50 1.0 nM
N#Cc1ncc2nc1OC/C=C\COc1cc(N(CCO)CCO)c(Cl)cc1NC(=O)N2 CHEMBL437772 IC50 1.0 nM
COc1cc(-c2ccc3c(c2)NC(=O)/C3=C\c2cc(C(=O)NCCN3CCOCC3)c(C)[se]2)ccc1O CHEMBL1223185 IC50 1.0 nM
NC(=O)c1ccc(-c2cc3c(N[C@H]4CCCNC4)ncc(C(N)=O)c3s2)cc1 CHEMBL1288278 IC50 1.0 nM
CN(C)C(=O)c1ccc(-c2cc3c(N[C@H]4CCCNC4)ncc(C(N)=O)c3s2)cc1 CHEMBL1287864 IC50 1.0 nM
NC(=O)c1nnc(N[C@H]2CCCNC2)c2cc(-c3ccc(Cl)cc3)sc12 CHEMBL1231624 IC50 1.0 nM
CN1c2ccc(N)cc2C(c2ccccc2)c2cc(N)ccc21 CHEMBL1991734 pKi 1.0 nM
CNCCNC(=O)c1cncc(-c2cnc(Nc3cc(N4CCOCC4)ccn3)s2)c1 CHEMBL2011355 IC50 1.0 nM
COc1ccc2c(c1)C(=O)N(c1nc(C(=O)Nc3cnccc3N3CCNCC3)cs1)C2 CHEMBL2381116 IC50 1.0 nM
N#Cc1cc2c(cn1)[nH]c1ncc(-c3ccc(CN4CCCCC4)cc3)cc12 CHEMBL3582201 IC50 1.0 nM
COC(=O)c1cnc(Nc2cnc(C#N)cn2)cc1N[C@H]1C[C@H]2CC[C@@H](C1)N2 CHEMBL4789854 IC50 1.0 nM
Oc1nc2ccc(Cl)cc2c(NC2CCCNC2)c1-c1nc2ccccc2[nH]1 CHEMBL210639 IC50 1.04 nM
Cn1cc(-c2ccc3[nH]c(=O)c(-c4cc5cc(CN6CCCCC6)ccc5[nH]4)cc3c2)cn1 CHEMBL221864 IC50 1.1 nM
COc1cc2c(cc1CN1CCC(O)CC1)Cc1c(-c3ccc(-c4ccc(O)cc4)cc3)n[nH]c1-2 CHEMBL234402 IC50 1.1 nM
COc1cc2c(cc1OCCc1scnc1C)-c1[nH]nc(-c3ccc(C#N)nc3)c1C2 CHEMBL249075 IC50 1.1 nM
N#Cc1ccc(-c2n[nH]c3c2Cc2ccc(OCCCn4ccnc4)cc2-3)cn1 CHEMBL251755 IC50 1.1 nM
c1cc(-c2cnc3[nH]c4cnc(-c5cnoc5)cc4c3c2)ccc1CN1CCCCC1 CHEMBL3582226 IC50 1.1 nM
O=C(CN[C@H]1CC[C@H](O)CC1)Nc1ccc2c(c1)Cc1c(-c3ccc(-c4ccc(O)cc4)cc3)n[nH]c1-2 CHEMBL234654 IC50 1.2 nM
Oc1ccc(-c2ccc(-c3cc(Nc4ccccc4)n[nH]3)cc2)c(O)c1 CHEMBL241024 Ki 1.2 nM
N#Cc1ccc(-c2n[nH]c3c2Cc2ccc(CCCCN4CCOCC4)cc2-3)cn1 CHEMBL249323 IC50 1.2 nM
Cc1[nH]nc2c1c(=O)n(CCCN)c1ccc(Cl)cc21 CHEMBL250843 IC50 1.2 nM
NCCCc1cc2c(-c3ccc(Cl)cc3Cl)c[nH]c(=O)c2c2cc(-c3cn[nH]c3)ccc12 CHEMBL250459 IC50 1.2 nM
NCCCc1cc2c(-c3ccc(Cl)cc3)c[nH]c(=O)c2c2cc(-c3cn[nH]c3)ccc12 CHEMBL250272 IC50 1.2 nM
COc1cc(CCNCc2cccc(F)c2)c(Cl)cc1NC(=O)Nc1cnc(C#N)cn1 CHEMBL3694353 IC50 1.2 nM
CCOc1cc(CCNCc2ccc(F)cc2)c(Cl)cc1NC(=O)Nc1cnc(C#N)cn1 CHEMBL3694378 IC50 1.2 nM
N#Cc1cnc(NC(=O)Nc2cc(Br)ccc2N2CCC[C@H](O)C2)cn1 CHEMBL537964 pKi 1.259 nM
CN1CCN(c2ccc(-c3cnc4[nH]c5cnc(C#N)cc5c4c3)cc2)CC1 CHEMBL3359895 IC50 1.3 nM
c1ncc(-c2cc3c(cn2)[nH]c2ncc(-c4ccc(CN5CCCCC5)cc4)cc23)s1 CHEMBL3582224 IC50 1.3 nM
CNc1nc(Nc2cnc(C#N)c(OC3CCN(C)CC3)c2)ncc1-c1cnn(C)c1 CHEMBL4470089 IC50 1.3 nM
N#Cc1cnc(Nc2cc(NC[C@H]3CNCCO3)c(C(F)(F)F)cn2)cn1 CHEMBL4169078 IC50 1.3 nM
Cc1ccc2nc(O)c(-c3nc4ccccc4[nH]3)c(NC3CCCNC3)c2c1 CHEMBL382437 IC50 1.4 nM
N#Cc1ccc(-c2n[nH]c3c2Cc2ccc(OCCCCCN4CCOCC4)cc2-3)cn1 CHEMBL249114 IC50 1.4 nM
NCCCNC(=O)c1cncc(-c2cnc(Nc3cc(N4CCOCC4)ccn3)s2)c1 CHEMBL2011351 IC50 1.4 nM
CN1CCN(c2ccc(CNCCc3ccc(NC(=O)Nc4cnc(C#N)cn4)cc3Cl)cc2)CC1 CHEMBL3694368 IC50 1.4 nM
CNc1nc(Nc2cnc(C#N)c(OC3CCCNC3)c2)ncc1-c1cccs1 CHEMBL4473680 IC50 1.43 nM
CC(=O)N1CCN(CCCCOc2ccc3c(c2)-c2[nH]nc(-c4ccc(C#N)nc4)c2C3)CC1 CHEMBL249283 IC50 1.5 nM
CN1CCN(CCCOc2ccc3c(c2)-c2[nH]nc(-c4ccc(C#N)nc4)c2C3)CC1 CHEMBL398754 IC50 1.5 nM
COc1cc(-c2ccc3c(c2)Nc2ccc(C(C)(C)CO)cc2NC3=O)ccc1[N+](=O)[O-] CHEMBL558077 pKi 1.585 nM
Nc1cc2c(cc1Cl)NC(=O)Nc1cncc(n1)OCC/C=C/CO2 CHEMBL542007 pKi 1.585 nM
COc1cc2c(cc1OC)-c1n[nH]c(-c3ccc(-c4ccc(O)cc4)cc3)c1C2 CHEMBL245796 pKi 1.585 nM
O=C(NCC(F)(F)F)c1cncc(-c2cnc(Nc3cc(N4CCOCC4)ccn3)s2)c1 CHEMBL2013167 IC50 1.6 nM
COc1cc(CCNCc2ccc(F)cc2)c(Cl)cc1NC(=O)Nc1cnc(C#N)cn1 CHEMBL3694370 IC50 1.6 nM
COc1ccc(CNCc2ccc(NC(=O)Nc3cnc(C#N)cn3)c(OC)c2)cc1 CHEMBL3694393 IC50 1.6 nM
N#Cc1c(-c2ccccc2)cc(-c2ccccc2)nc1/N=C1\S/C(=C2\SC(c3ccccc3)=NN2c2ccccc2)C(=O)N1c1ccccc1 CHEMBL3408393 IC50 1.65 nM
CS(=O)(=O)N1CCN(c2ccnc(Nc3ncc(-c4cncc(C(=O)NCC(F)(F)F)c4)s3)c2)CC1 CHEMBL2013168 IC50 1.7 nM
N#Cc1ccc(-c2n[nH]c3c2Cc2ccc(OCCOCCN4CCOCC4)cc2-3)cn1 CHEMBL400797 IC50 1.8 nM
N#Cc1cc2c(cn1)[nH]c1ncc(-c3ccc(CN4CCC(O)CC4)cc3)cc12 CHEMBL3582207 IC50 1.8 nM
CNc1nc(Nc2cnc(C#N)c(OC3CCCNC3)c2)ncc1-c1ccc(C(=O)OC)s1 CHEMBL4455460 IC50 1.8 nM
COc1cc2c(cc1CCCO)NC(=O)c1ccc(-c3ccc([N+](=O)[O-])c(OC)c3)cc1N2 CHEMBL270417 IC50 1.9 nM
CN1CCN(c2cccc(-c3cnc4[nH]c5cnc(C#N)cc5c4c3)c2)CC1 CHEMBL3582200 IC50 1.9 nM
N#Cc1cc2c(cn1)[nH]c1ncc(-c3ccc(CN4CCC[C@@H](O)C4)cc3)cc12 CHEMBL3582208 IC50 1.9 nM
N#Cc1cnc(Nc2cc(NC[C@H]3CNCCO3)c(Cl)cn2)cn1 CHEMBL4754960 IC50 1.9 nM
N#Cc1ncc(Nc2ncc(-c3cccs3)cn2)cc1OC1CCCNC1 CHEMBL4466510 IC50 1.96 nM
N#Cc1cnc(NC(=O)Nc2cc(Cl)ccc2OCC2C[C@@H](O)[C@@H](O)C2)cn1 CHEMBL551086 pKi 1.995 nM
COc1cc2c(cc1OCCCCO)Nc1cc(Nc3cc(F)nc(F)c3)ccc1C(=O)N2 CHEMBL541515 pKi 1.995 nM
CCN(CC)CC#Cc1cc2c(cc1Cl)NC(=O)Nc1cnc(C#N)c(n1)OCCCCCO2 CHEMBL219689 IC50 2.0 nM
N#Cc1ncc2nc1OCCCCCOc1cc(NC(=O)CCNC3CCCC3)c(Cl)cc1NC(=O)N2 CHEMBL223589 IC50 2.0 nM
Cn1cncc1CNc1cc2c(cc1Cl)NC(=O)Nc1cnc(C#N)c(n1)OCCCCCO2 CHEMBL375144 IC50 2.0 nM
N#Cc1ncc2nc1OCCCCCOc1cc(NCCO)c(Cl)cc1NC(=O)N2 CHEMBL222421 IC50 2.0 nM
CNc1cc2c(cc1Cl)NC(=O)Nc1cnc(C#N)c(n1)OCCCCCO2 CHEMBL223672 IC50 2.0 nM
N#Cc1ncc2nc1OCCCCCOc1cc(OCCCO)c(Cl)cc1NC(=O)N2 CHEMBL373598 IC50 2.0 nM
COc1cc(-c2ccc3c(c2)Nc2ccc(CCC(=O)N(C)C)cc2NC3=O)ccc1N CHEMBL395775 IC50 2.0 nM
COc1cc(-c2ccc3c(c2)Nc2ccc(N4CCCS4(=O)=O)cc2NC3=O)ccc1N CHEMBL242412 IC50 2.0 nM
Oc1ccc(-c2ccc(-c3n[nH]c4c3Cc3cc(CN5CCC(O)CC5)ccc3-4)cc2)cc1 CHEMBL242325 IC50 2.0 nM
N#Cc1ncc2nc1OCCCCOc1ccc(OCCCN3CCOCC3)cc1NC(=O)N2 CHEMBL235604 IC50 2.0 nM
N#Cc1ncc2nc1OC/C=C\COc1ccc(OCCCCCN3CCCOC3)cc1NC(=O)N2 CHEMBL235381 IC50 2.0 nM
COc1cc2c(cc1OCCN(C)C)Cc1c-2n[nH]c1-c1ccc(-c2ccc(O)cc2)cc1 CHEMBL391989 IC50 2.0 nM
CCN(CC)CC(CN(CC)CC)Oc1cc2c(cc1OC)Cc1c-2n[nH]c1-c1ccc(-c2ccc(O)cc2)cc1 CHEMBL246842 IC50 2.0 nM
COc1cc2c(cc1OCCN1CCCC1)-c1n[nH]c(-c3ccc(-c4ccc(O)cc4)cc3)c1C2 CHEMBL245602 IC50 2.0 nM
COc1cc2c(cc1OC(C)CN(C)C)-c1n[nH]c(-c3ccc(-c4ccc(O)cc4)cc3)c1C2 CHEMBL398465 IC50 2.0 nM
COc1cc2c(cc1OCCN1CCOCC1)Cc1c-2n[nH]c1-c1ccc(-c2ccc(O)cc2)cc1 CHEMBL429294 IC50 2.0 nM
COc1cc2c(cc1OCC[C@@H]1CCCN1)Cc1c-2n[nH]c1-c1ccc(-c2ccc(O)cc2)cc1 CHEMBL248007 IC50 2.0 nM
COc1cc2c(cc1OC(C)CN(C)C)Cc1c-2n[nH]c1-c1ccc(-c2ccc(O)cc2)cc1 CHEMBL247827 IC50 2.0 nM
COc1cc2c(cc1O)Cc1c-2n[nH]c1-c1ccc(C#N)cc1 CHEMBL247222 IC50 2.0 nM
COc1cc2c(cc1OC1CCOC1)Cc1c-2n[nH]c1-c1ccc(C#N)cc1 CHEMBL247590 IC50 2.0 nM
COc1cc2c(cc1Cn1ccnc1)Cc1c-2n[nH]c1-c1ccc(C#N)cc1 CHEMBL247396 IC50 2.0 nM
COc1cc2c(cc1OC)-c1n[nH]c(-c3ccc(F)nc3)c1C2 CHEMBL247026 IC50 2.0 nM
COc1cc2c(cc1OC)-c1n[nH]c(-c3ccc(C(=O)O)cc3)c1C2 CHEMBL397313 IC50 2.0 nM
NCCCc1cc2c(-c3ccccc3O)c[nH]c(=O)c2c2cc(-c3cn[nH]c3)ccc12 CHEMBL249241 IC50 2.0 nM
NCCCc1cc2c(-c3ccccc3)c[nH]c(=O)c2c2cc(-c3cn[nH]c3)ccc12 CHEMBL249240 IC50 2.0 nM
CN(C)CCNC(=O)c1ccc2c(CCCN)cc3cc[nH]c(=O)c3c2c1 CHEMBL249238 IC50 2.0 nM
CNc1cc2c(cc1Cl)NC(=O)Nc1cnc(C#N)c(n1)OCCCCO2 CHEMBL248755 IC50 2.0 nM
CN(C)c1cc2c(cc1Cl)NC(=O)Nc1cnc(C#N)c(n1)OCCCCO2 CHEMBL400574 IC50 2.0 nM
N#Cc1ncc2nc1OC/C=C\COc1cc(OCCCO)c(Cl)cc1NC(=O)N2 CHEMBL398757 IC50 2.0 nM
N#Cc1ncc2nc1OC/C=C\COc1cc(NCCO)c(Cl)cc1NC(=O)N2 CHEMBL249765 IC50 2.0 nM
CNc1cc2c(cc1Cl)NC(=O)Nc1cnc(C#N)c(n1)OC/C=C\CO2 CHEMBL249764 IC50 2.0 nM
CN(C)c1cc2c(cc1Cl)NC(=O)Nc1cnc(C#N)c(n1)OC/C=C\CO2 CHEMBL400693 IC50 2.0 nM
CNCCCn1c2ccc(O)cc2c2c3c(c(-c4ccccc4)cc21)C(=O)NC3=O CHEMBL455192 IC50 2.0 nM
NC(=O)Nc1sc(-c2ccc(Cl)cc2)cc1C(=O)NC1CCCCC1 CHEMBL1288101 IC50 2.0 nM
CC(=O)Nc1cccc(-c2cc3c(N[C@H]4CCCNC4)ncc(C(N)=O)c3s2)c1 CHEMBL1287862 IC50 2.0 nM
NC(=O)c1cnc(N[C@H]2CCCNC2)c2cc(-c3cccc(N)c3)sc12 CHEMBL1287863 IC50 2.0 nM
NC(=O)c1cnc(N[C@H]2CCCNC2)c2cc(-c3ccc(F)c(F)c3)sc12 CHEMBL1287892 IC50 2.0 nM
CS(=O)(=O)c1ccc(-c2cc3c(N[C@H]4CCCNC4)ncc(C(N)=O)c3s2)cc1 CHEMBL1288133 IC50 2.0 nM
NC(=O)c1cnc(N[C@H]2CCCNC2)c2cc(-c3cc4ccccc4o3)sc12 CHEMBL1288222 IC50 2.0 nM
O=C(Nc1cnccc1N1CCNCC1)c1csc(N2Cc3ccccc3C2=O)n1 CHEMBL2381115 IC50 2.0 nM
O=C(Nc1ccccc1N1CCNCC1)c1csc(Nc2n[nH]c3ccccc23)n1 CHEMBL2381249 IC50 2.0 nM
O=C(Nc1ccccc1N1CCNCC1)c1csc(-n2ncc3ccccc32)n1 CHEMBL2381246 IC50 2.0 nM
N#Cc1cnc(NC(=O)Nc2ccc(CCNCc3cccc(F)c3)c(Cl)c2)cn1 CHEMBL3694343 IC50 2.0 nM
COCC(=O)N1CCN(Cc2ccc3[nH]c(-c4cc5cc(-c6cn[nH]c6)ccc5[nH]c4=O)cc3c2)CC1 CHEMBL374518 IC50 2.1 nM
CC[C@@]1(O)C(=O)OCc2c1cc1n(c2=O)Cc2cc3ccccc3nc2-1 CHEMBL65 EC50 2.1 nM
CCCCNCC(=O)Nc1ccc2c(c1)Cc1c(-c3ccc(-c4ccc(O)cc4)cc3)n[nH]c1-2 CHEMBL392516 IC50 2.1 nM
C[C@@H]1CCC[C@H](C)N1Cc1ccc(-c2cnc3[nH]c4cnc(C#N)cc4c3c2)cc1 CHEMBL3582202 IC50 2.1 nM
N#Cc1cnc(Nc2cc(NC[C@@H]3CNCCO3)c(C#CC3(O)CCCC3)cn2)cn1 CHEMBL4784718 IC50 2.1 nM
Cn1cc(-c2cnc3c(-c4csc(C(=O)N[C@@H]5CCCC[C@@H]5N)c4)cnn3c2)cn1 CHEMBL4568087 IC50 2.2 nM
COC(=O)c1cnc(Nc2cnc(C#N)cn2)cc1NCC1CNCCO1 CHEMBL4782664 IC50 2.2 nM
CC(C)(O)C#Cc1cnc(Nc2cnc(C#N)cn2)cc1NC[C@@H]1CNCCO1 CHEMBL4793954 IC50 2.2 nM
CC(=O)N1CCN(Cc2ccc3[nH]c(-c4n[nH]c5cc(-c6nnn[nH]6)ccc45)cc3c2)CC1 CHEMBL219731 IC50 2.3 nM
COc1cc2c(cc1C(=O)N1CCN(C)CC1)Cc1c(-c3ccc(-c4ccc(O)cc4)cc3)n[nH]c1-2 CHEMBL444630 IC50 2.3 nM
CNC(=O)c1ccc2c(c1)-c1[nH]nc(-c3ccc(-c4ccc(O)cc4)cc3)c1C2 CHEMBL232806 IC50 2.3 nM
NCCCc1cc2c(Br)c[nH]c(=O)c2c2cc(-c3cn[nH]c3)ccc12 CHEMBL249044 IC50 2.3 nM
CN1CCN(c2ccc(-c3cnc4[nH]c5cnc(C(N)=O)cc5c4c3)cc2)CC1 CHEMBL3359894 IC50 2.3 nM
c1cnc(-c2cc3c(cn2)[nH]c2ncc(-c4ccc(CN5CCCCC5)cc4)cc23)cn1 CHEMBL3582230 IC50 2.3 nM
CCN1CCc2cc(-c3cnc4[nH]c5cnc(C#N)cc5c4c3)ccc2C1 CHEMBL3582215 IC50 2.3 nM
COc1ccc2[nH]c(-c3c(N[C@H]4CCCNC4)c4cc(Cl)sc4[nH]c3=O)nc2c1 CHEMBL3330232 IC50 2.33 nM
NCCCc1cc2cc[nH]c(=O)c2c2cc(-c3ccc[nH]3)ccc12 CHEMBL400350 IC50 2.4 nM
CNc1nc(Nc2cnc(C#N)c(O[C@@H]3CCNC3)c2)ncc1-c1cnn(C)c1 CHEMBL4562902 IC50 2.43 nM
CC(=O)N1CCN(Cc2ccc3[nH]c(-c4cc5cc(-c6cn[nH]c6)ccc5[nH]c4=O)cc3c2)CC1 CHEMBL220653 IC50 2.5 nM
COc1cc2c(cc1OCCc1scnc1C)Cc1c(-c3ccc(C#N)nc3)n[nH]c1-2 CHEMBL400795 IC50 2.5 nM
NCCc1cc2cc[nH]c(=O)c2c2cc(-c3ccn[nH]3)ccc12 CHEMBL400127 IC50 2.5 nM
N#Cc1cc2c(cn1)[nH]c1ncc(-c3ccc(CN4CCC5(CC4)COC5)cc3)cc12 CHEMBL3582212 IC50 2.5 nM
COc1cccc(-c2ccc3c(c2)Nc2ccc(CCC(=O)N(C)C)cc2NC3=O)c1 CHEMBL559425 pKi 2.512 nM
CC(C)(O)c1ccc2c(c1)NC(=O)c1ccc(Nc3ccncc3)cc1N2 CHEMBL540756 pKi 2.512 nM
COc1cc2c(cc1OCCCN1CCOCC1)Cc1c(-c3ccccc3)n[nH]c1-2 CHEMBL559621 pKi 2.512 nM
CNC1CC2OC(C)(C1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL1980995 pKi 2.512 nM
CNc1nc(Nc2cnc(C#N)c(OC3CCCNC3)c2)ncc1-c1ccccc1 CHEMBL4587139 IC50 2.56 nM
N#Cc1c(-c2ccccc2)cc(-c2ccccc2)nc1/N=C1\S/C(=C2\SC(C(=O)Nc3ccccc3)=NN2c2ccccc2)C(=O)N1c1ccccc1 CHEMBL3408396 IC50 2.57 nM
CNc1nc(Nc2cnc(C#N)c(OC3CCCNC3)c2)ncc1-c1ccco1 CHEMBL4443253 IC50 2.58 nM
c1cn(-c2ccc3c(-c4cc5cc(CN6CCCCC6)ccc5[nH]4)n[nH]c3c2)nn1 CHEMBL220946 IC50 2.6 nM
COc1cc2c(cc1OCCO)-c1[nH]nc(-c3ccc(C#N)nc3)c1C2 CHEMBL400796 IC50 2.6 nM
N#Cc1ccc(-c2n[nH]c3c2Cc2ccc(OCCCN4CCCCC4)cc2-3)cn1 CHEMBL248720 IC50 2.6 nM
NCCCc1cc2c(-c3ccccc3F)c[nH]c(=O)c2c2cc(-c3cn[nH]c3)ccc12 CHEMBL249632 IC50 2.6 nM
COc1cc2c(cc1CCCO)Nc1cc(-c3ccc([N+](=O)[O-])c(OC)c3)ccc1C(=O)N2 CHEMBL255183 IC50 2.6 nM
COc1cc(-c2ccc3c(c2)NC(=O)/C3=C\c2ccc(C(=O)NCCN(C)C)[se]2)ccc1O CHEMBL1223044 IC50 2.6 nM
COc1cc(CCNCCc2ccc(F)cc2)ccc1NC(=O)Nc1cnc(C#N)cn1 CHEMBL3694364 IC50 2.7 nM
CO[C@H]1[C@H](O)[C@H]2[C@@H](O[C@@H]1CN)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4=O CHEMBL491263 IC50 2.8 nM
C[C@]12O[C@H](C[C@]1(O)CO)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)CNC4=O CHEMBL603469 Kd 2.8 nM
N=C(N)NCCNC(=O)c1cccc(CNC(=O)c2cc3c(c4c2[nH]c2ccc(O)cc24)C(=O)NC3=O)c1 CHEMBL1276955 IC50 2.8 nM
COc1cc(CCNCc2ccc(F)cc2)ccc1NC(=O)Nc1cnc(C#N)cn1 CHEMBL3694354 IC50 2.8 nM
COc1cc(CNCc2ccccc2)c(Cl)cc1NC(=O)Nc1cnc(C#N)cn1 CHEMBL3694389 IC50 2.8 nM
O=c1[nH]c2ccc(Br)cc2cc1-c1cc2cc(CN3CCCCC3)ccc2[nH]1 CHEMBL221863 IC50 2.9 nM
CNc1cc(Nc2cnc(C#N)c(O[C@H](C)CN(C)C)n2)ncc1C#CC(C)(C)O CHEMBL2204590 IC50 2.9 nM
c1cc(-c2cc3c(cn2)[nH]c2ncc(-c4ccc(CN5CCCCC5)cc4)cc23)cnn1 CHEMBL3582231 IC50 2.9 nM
COC(=O)c1cnc(Nc2cnc(C#N)cn2)cc1NC1CCN(C)CC1 CHEMBL4784549 IC50 2.9 nM
N#Cc1cnc(NC(=O)Nc2cc(Cl)ccc2OC2CCOC2)cn1 CHEMBL195373 IC50 3.0 nM
COc1cc(NC(=O)CN(C)C)c(Cl)cc1NC(=O)Nc1cnc(C#N)cn1 CHEMBL381517 IC50 3.0 nM
CC(=O)N1CCN(Cc2ccc3[nH]c(-c4cc5cc(-c6cnn(C)c6)ccc5[nH]c4=O)cc3c2)CC1 CHEMBL220973 IC50 3.0 nM
N#Cc1ncc2nc1OCCCCCOc1cc(N)c(Cl)cc1NC(=O)N2 CHEMBL373897 IC50 3.0 nM
N#Cc1ncc2nc1OCCCCCOc1cc(OCCn3ccnc3)c(Cl)cc1NC(=O)N2 CHEMBL219979 IC50 3.0 nM
N#Cc1ncc2nc1OCCCCCOc1cc(OCC(O)CO)c(Cl)cc1NC(=O)N2 CHEMBL223257 IC50 3.0 nM
COC(=O)Cc1ccc2c(c1)NC(=O)c1ccc(-c3ccc(N)c(OC)c3)cc1N2 CHEMBL429819 IC50 3.0 nM
N#Cc1ncc2nc1OCCCCOc1ccc(OCCCCCN3CCCOC3)cc1NC(=O)N2 CHEMBL235606 IC50 3.0 nM
N#Cc1ncc2nc1OCCCCCOc1ccc(OCCCCCN3CCOCC3)cc1NC(=O)N2 CHEMBL236023 IC50 3.0 nM
N#Cc1ncc2nc1OCCCCCOc1ccc(OCCCCN3CCOCC3)cc1NC(=O)N2 CHEMBL235801 IC50 3.0 nM
COc1cc2c(cc1OCCn1ccnc1)-c1n[nH]c(-c3ccc(-c4ccc(O)cc4)cc3)c1C2 CHEMBL400790 IC50 3.0 nM
COc1cc2c(cc1OCCN1CCOCC1)-c1[nH]nc(-c3ccc(C#N)nc3)c1C2 CHEMBL248871 IC50 3.0 nM
COc1cc2c(cc1C(=O)N[C@H]1CC[C@H](O)CC1)Cc1c-2n[nH]c1-c1ccc(C#N)cc1 CHEMBL245401 IC50 3.0 nM
COc1cc2c(cc1OCC1CCOC1)Cc1c-2n[nH]c1-c1ccc(C#N)cc1 CHEMBL247588 IC50 3.0 nM
COc1cc2c(cc1OC(CO)CO)Cc1c-2n[nH]c1-c1ccc(C#N)cc1 CHEMBL400893 IC50 3.0 nM
COc1cc2c(cc1OCCCN1CCOCC1)Cc1c-2n[nH]c1-c1ccc(C#N)cc1 CHEMBL400689 IC50 3.0 nM
NCCc1cc2cc[nH]c(=O)c2c2cc(-c3cn[nH]c3)ccc12 CHEMBL428409 IC50 3.0 nM
NCCc1cc2cc[nH]c(=O)c2c2cc(Br)ccc12 CHEMBL249796 IC50 3.0 nM
COCCCOc1cc2c(cc1Cl)NC(=O)Nc1cnc(C#N)c(n1)OCCCCO2 CHEMBL400806 IC50 3.0 nM
N#Cc1ncc2nc1OCCCCOc1cc(NC(=O)OCCN3CCOCC3)c(Cl)cc1NC(=O)N2 CHEMBL248952 IC50 3.0 nM
CCNc1cc2c(cc1Cl)NC(=O)Nc1cnc(C#N)c(n1)OCCCCO2 CHEMBL400575 IC50 3.0 nM
N#Cc1ncc2nc1OC/C=C\COc1cc(NC(=O)OCCN3CCOCC3)c(Cl)cc1NC(=O)N2 CHEMBL400668 IC50 3.0 nM
C[C@H](N)C(=O)Nc1cc2c(cc1Cl)NC(=O)Nc1cnc(C#N)c(n1)OC/C=C\CO2 CHEMBL250173 IC50 3.0 nM
CN(C)CCCOc1cc2[nH]c3cc(-c4ccccc4Cl)c4c(c3c2cc1O)C(=O)NC4=O CHEMBL272479 IC50 3.0 nM
CNCC(O)Cn1c2ccc(O)cc2c2c3c(c(-c4ccccc4Cl)cc21)C(=O)NC3=O CHEMBL516488 IC50 3.0 nM
NC(=O)Nc1sc(-c2ccccc2)cc1C(=O)N[C@@H]1CCCCNC1 CHEMBL471096 IC50 3.0 nM
NC(=O)Nc1sc(-c2cccs2)cc1C(=O)N[C@H]1CCCNC1 CHEMBL519913 IC50 3.0 nM
NC(=O)c1cnc(N[C@H]2CCCNC2)c2cc(-c3ccc(Cl)cc3)sc12 CHEMBL1231626 IC50 3.0 nM
NC(=O)c1cnc(N[C@H]2CCCCNC2)c2cc(-c3ccc(Cl)cc3)sc12 CHEMBL1288162 IC50 3.0 nM
NC(=O)c1cnc(N[C@H]2CCCNC2)c2cc(-c3ccncc3)sc12 CHEMBL1287891 IC50 3.0 nM
COc1cccc(-c2cc3c(N[C@H]4CCCNC4)ncc(C(N)=O)c3s2)c1 CHEMBL1287979 IC50 3.0 nM
COc1ccc(-c2cc3c(N[C@H]4CCCNC4)ncc(C(N)=O)c3s2)cc1 CHEMBL1288009 IC50 3.0 nM
NC(=O)c1cnc(N[C@H]2CCCNC2)c2cc(-c3cccc(CO)c3)sc12 CHEMBL1288010 IC50 3.0 nM
NC(=O)c1cnc(N[C@H]2CCCNC2)c2cc(-c3cccc(N4CCCC4)c3)sc12 CHEMBL1288305 IC50 3.0 nM
COc1ccc(-c2cc3c(N[C@H]4CCCNC4)ncc(C(N)=O)c3s2)cn1 CHEMBL1287865 IC50 3.0 nM
Cn1cc(-c2cnn3c(N)c(Cl)c(C4CCCNC4)nc23)cn1 CHEMBL1643207 IC50 3.0 nM
Cn1cc(-c2cnn3c(N)c(Br)c(C4CCCNC4)nc23)cn1 CHEMBL1643208 IC50 3.0 nM
Cn1cc(-c2cnn3c(N)c(I)c(C4CCCNC4)nc23)cn1 CHEMBL1643209 IC50 3.0 nM
COCc1cc2n[nH]c(=O)n2c2cc(-c3ccsc3)ccc12 CHEMBL2012879 IC50 3.0 nM
O=C(Nc1cnccc1N1CCNCC1)c1csc(Nc2n[nH]c3ccccc23)n1 CHEMBL2381222 IC50 3.0 nM
O=C(Nc1cnccc1N1CCNCC1)c1csc(-n2ncc3ccccc32)n1 CHEMBL2381221 IC50 3.0 nM
O=C(Nc1cnccc1N1CCNCC1)c1csc(-c2cc3ccccc3s2)n1 CHEMBL2381112 IC50 3.0 nM
COc1ccc(-c2cc(Nc3nc(C(=O)Nc4ccccc4N4CCNCC4)cs3)[nH]n2)cc1 CHEMBL2381102 IC50 3.0 nM
Cn1cc(-c2cnn3c(N)c(Br)c([C@@H]4CCCNC4)nc23)cn1 CHEMBL2386889 IC50 3.0 nM
COc1cc(OCCNCc2ccc(F)cc2F)ccc1NC(=O)Nc1cnc(C#N)cn1 CHEMBL3694366 IC50 3.0 nM
COc1cc2c(cc1OCCO)Cc1c(-c3ccc(C#N)nc3)n[nH]c1-2 CHEMBL248870 IC50 3.1 nM
Cc1[nH]nc2c1c(=O)n(C[C@H](F)CN)c1cc(C3CCCCC3)c(C3CCCCC3)cc21 CHEMBL398612 IC50 3.1 nM
COCCOCCOc1cc2c(cc1OC)NC(=O)c1ccc(-c3ccc([N+](=O)[O-])c(OC)c3)cc1N2 CHEMBL404152 IC50 3.1 nM
CNc1cc(Nc2cnc(C#N)c(O[C@H](C)CN(C)C)n2)ncc1-c1cnn(C)c1 CHEMBL2204592 IC50 3.1 nM
N#Cc1cnc(NC(=O)Nc2cc(Cl)ccc2N2CCCC2)cn1 CHEMBL550209 pKi 3.162 nM
CCN(CC)CC#Cc1ccc2c(c1)-c1[nH]nc(-c3ccc(C#N)nc3)c1C2 CHEMBL2007044 pKi 3.162 nM
N#Cc1ccc(-c2n[nH]c3c2Cc2ccc(OCCCN4CCOCC4)cc2-3)cn1 CHEMBL248911 IC50 3.2 nM
Cc1[nH]nc2c1c(=O)n(C[C@@H](F)CN)c1cc(C3CCCCC3)c(C3CCCCC3)cc21 CHEMBL249177 IC50 3.2 nM
Cn1cc(-c2cnc(Nc3cnc(C#N)cn3)cc2NC[C@@H]2CNCCO2)cn1 CHEMBL4789820 IC50 3.2 nM
Oc1nc2ccc(Cl)cc2c(NC2CCNCC2)c1-c1nc2ccccc2[nH]1 CHEMBL381952 IC50 3.3 nM
Cc1ccc2nc(O)c(-c3nc4ccccc4[nH]3)c(NC3CCNCC3)c2c1 CHEMBL210242 IC50 3.3 nM
COc1cc(CCN[C@H](C)c2ccc(F)cc2)ccc1NC(=O)Nc1cnc(C#N)cn1 CHEMBL3694376 IC50 3.3 nM
COc1cc(CCNCc2ccc(N3CCN(C)CC3)cc2)ccc1NC(=O)Nc1cnc(C#N)cn1 CHEMBL3694384 IC50 3.3 nM
CNc1nc(Nc2cnc(C#N)c(N[C@@H]3CCNC3)c2)ncc1C(F)(F)F CHEMBL4862023 IC50 3.3 nM
COc1cc2c(cc1CC(C)(C)O)Nc1cc(-c3ccc([N+](=O)[O-])c(OC)c3)ccc1C(=O)N2 CHEMBL403192 IC50 3.4 nM
CNc1cc(Nc2cnc(C#N)c(O[C@H]3CCN(C)C3)n2)ncc1-c1cnn(C)c1 CHEMBL2203842 IC50 3.4 nM
CCOC(=O)C1=NN(c2ccccc2)/C(=C2/S/C(=N\c3nc(-c4ccccc4)cc(-c4ccccc4)c3C#N)N(c3ccccc3)C2=O)S1 CHEMBL3408395 IC50 3.48 nM
NCCCc1cc2c(-c3ccc(F)cc3)c[nH]c(=O)c2c2cc(-c3cn[nH]c3)ccc12 CHEMBL250033 IC50 3.5 nM
NCCCc1cc2cc[nH]c(=O)c2c2cc(-c3cn[nH]c3)ccc12 CHEMBL249224 IC50 3.5 nM
COc1cc2c(cc1CCO)Nc1cc(-c3ccc([N+](=O)[O-])c(OC)c3)ccc1C(=O)N2 CHEMBL257067 IC50 3.5 nM
COc1ccc(CNCCc2ccc(NC(=O)Nc3cnc(C#N)cn3)cc2Cl)cc1 CHEMBL3694349 IC50 3.5 nM
O=c1[nH]c2sc(Cl)cc2c(N[C@H]2CCCNC2)c1-c1nc2ccccc2[nH]1 CHEMBL3330227 IC50 3.53 nM
O=C(c1ccc2c(c1)Cc1c(-c3ccc(-c4ccc(O)cc4)cc3)n[nH]c1-2)N1CCC(O)CC1 CHEMBL242754 IC50 3.6 nM
C=Cc1c[nH]c(=O)c2c1cc(CCCN)c1ccc(-c3cn[nH]c3)cc12 CHEMBL401156 IC50 3.6 nM
CNc1nc(Nc2cnc(C#N)c(OC3CCCNC3)c2)ncc1-c1cccc(OC)c1 CHEMBL4570849 IC50 3.62 nM
COc1cc2c(cc1OCc1ccccn1)Cc1c(-c3ccc(C#N)nc3)n[nH]c1-2 CHEMBL400744 IC50 3.7 nM
NCCCc1cc2c(-c3cccc(F)c3)c[nH]c(=O)c2c2cc(-c3cn[nH]c3)ccc12 CHEMBL249834 IC50 3.7 nM
COc1cc(-c2ccc3c(c2)NC(=O)/C3=C\c2ccc(C(=O)NCCCn3ccnc3)[se]2)ccc1O CHEMBL1223118 IC50 3.7 nM
Cn1cc(-c2cnc(Nc3cnc(C#N)c(OC4CCCNC4)c3)nc2)cn1 CHEMBL4562325 IC50 3.75 nM
COc1cc2c(cc1OCCN1CCOCC1)Cc1c(-c3ccc(C#N)nc3)n[nH]c1-2 CHEMBL248680 IC50 3.8 nM
N#Cc1ncc(Nc2cc3cccc(Cl)c3cn2)nc1OC1CCCNC1 CHEMBL1928701 IC50 3.8 nM
Oc1ccc(-c2ccc(-c3n[nH]c4c3Cc3cc(CN[C@H]5CC[C@H](O)CC5)ccc3-4)cc2)cc1 CHEMBL242535 IC50 3.9 nM
COc1cc(N)c(Cl)cc1NC(=O)Nc1cnc(C#N)cn1 CHEMBL207596 pKi 3.981 nM
N#Cc1cnc(NC(=O)Nc2cc3ccccc3cc2O)cn1 CHEMBL560210 pKi 3.981 nM
OCc1ccc2c(c1)-c1[nH]nc(-c3ccc(-c4ccc(O)cc4)cc3)c1C2 CHEMBL232804 pKi 3.981 nM
COc1cccc(-c2ccc3c(c2)Nc2cc(OCc4csc(C)n4)c(OC)cc2NC3=O)c1 CHEMBL549527 pKi 3.981 nM
N#Cc1ncc2nc1OCCCCCOc1cc(CCCO)c(Cl)cc1NC(=O)N2 CHEMBL223367 pKi 3.981 nM
N#Cc1ncc2nc1OCCCCOc1cc(NCc3cncs3)c(Cl)cc1NC(=O)N2 CHEMBL248757 pKi 3.981 nM
COc1cc(-c2ccc3c(c2)NC(=O)/C3=C\c2c[nH]c3ncccc23)ccc1O CHEMBL383316 IC50 4.0 nM
N#Cc1ccc2[nH]c(=O)c(-c3cc4cc(CN5CCC(CN)CC5)ccc4[nH]3)cc2c1 CHEMBL221862 IC50 4.0 nM
N#Cc1ncc2nc1OCCCCCOc1cc(N(CCO)CCO)c(Cl)cc1NC(=O)N2 CHEMBL223640 IC50 4.0 nM
CCNc1cc2c(cc1Cl)NC(=O)Nc1cnc(C#N)c(n1)OCCCCCO2 CHEMBL220525 IC50 4.0 nM
COc1cc(-c2ccc3c(c2)Nc2cc(N4CCOCC4)ccc2NC3=O)ccc1N CHEMBL243721 IC50 4.0 nM
COc1cc(-c2ccc3c(c2)Nc2ccc(N4CCCC4=O)cc2NC3=O)ccc1N CHEMBL413224 IC50 4.0 nM
CN(C)CCNC(=O)c1ccc2c(c1)Cc1c(-c3ccc(-c4ccc(O)cc4)cc3)n[nH]c1-2 CHEMBL242537 IC50 4.0 nM
N#Cc1ncc2nc1OCCCCOc1ccc(OCCCCN3CCOCC3)cc1NC(=O)N2 CHEMBL235605 IC50 4.0 nM
N#Cc1ncc2nc1OC/C=C\COc1ccc(OCCCCN3CCOCC3)cc1NC(=O)N2 CHEMBL235163 IC50 4.0 nM
N#Cc1ncc2nc1OC/C=C\COc1ccc(OCCCN3CCOCC3)cc1NC(=O)N2 CHEMBL235161 IC50 4.0 nM
COc1cc2c(cc1OCCCN1CCCCC1)Cc1c-2n[nH]c1-c1ccc(-c2ccc(O)cc2)cc1 CHEMBL247459 IC50 4.0 nM
COc1cc2c(cc1OCCCN(C)C)Cc1c-2n[nH]c1-c1ccc(C#N)cc1 CHEMBL247201 IC50 4.0 nM
COc1cc2c(cc1OC)-c1n[nH]c(-c3ccc(Cl)nc3)c1C2 CHEMBL399254 IC50 4.0 nM
N#Cc1ncc2nc1OCCCCOc1cc(NC(=O)c3ccnc(Cl)c3)c(Cl)cc1NC(=O)N2 CHEMBL400804 IC50 4.0 nM
N#Cc1ncc2nc1OCCCCOc1cc(NC(=O)c3ccncc3)c(Cl)cc1NC(=O)N2 CHEMBL248951 IC50 4.0 nM
N#Cc1ncc2nc1OC/C=C\COc1cc(NCc3cncs3)c(Cl)cc1NC(=O)N2 CHEMBL249971 IC50 4.0 nM
Cn1c2cc(CCCCN3CCCC3)c(O)cc2c2c3c(c(-c4ccccc4Cl)cc21)C(=O)NC3=O CHEMBL271084 IC50 4.0 nM
COc1cc2c(cc1CCC(C)(C)O)Nc1cc(-c3ccc([N+](=O)[O-])c(OC)c3)ccc1C(=O)N2 CHEMBL404479 IC50 4.0 nM
COc1cc2c(cc1OCc1csc(C)n1)Nc1cc(-c3ccc([N+](=O)[O-])c(OC)c3)ccc1C(=O)N2 CHEMBL257703 IC50 4.0 nM
NC(=O)Nc1sc(-c2ccncc2)cc1C(=O)N[C@H]1CCCNC1 CHEMBL488231 IC50 4.0 nM
Cc1cc2n[nH]c(=O)n2c2cc(-c3cn[nH]c3)ccc12 CHEMBL1223528 IC50 4.0 nM
NC(=O)c1cnc(N[C@H]2CCCNC2)c2cc(-c3cccc(Cl)c3)sc12 CHEMBL1288303 IC50 4.0 nM
NC(=O)c1cnc(N[C@H]2CCCNC2)c2cc(-c3ccccc3)sc12 CHEMBL1287920 IC50 4.0 nM
NC(=O)c1cnc(N[C@H]2CCCNC2)c2cc(-c3ccc4sccc4c3)sc12 CHEMBL1288042 IC50 4.0 nM
NC(=O)c1cnc(N[C@H]2CCCNC2)c2cc(-c3ccc(Oc4ccccc4)cc3)sc12 CHEMBL1288043 IC50 4.0 nM
NC(=O)c1cnc(N[C@H]2CCCNC2)c2cc(-c3ccc(F)c(Cl)c3)sc12 CHEMBL1288221 IC50 4.0 nM
CN1CCN(Cc2cc(-c3ccc4c(N)cc5n[nH]c(=O)n5c4c3)cs2)CC1 CHEMBL2012859 IC50 4.0 nM
O=C(Nc1ccccc1N1CCNCC1)c1csc(-c2ccc3[nH]ccc3c2)n1 CHEMBL2037112 IC50 4.0 nM
COc1ccc2c(c1)C(=O)N(c1nc(C(=O)Nc3cc(F)ccc3N3CCNCC3)cs1)C2 CHEMBL2381223 IC50 4.0 nM
CCS(=O)(=O)N1CCN(c2ccc(Nc3ncc(C(N)=O)c(NC4CC4)n3)cc2)CC1 CHEMBL4116008 IC50 4.0 nM
O=c1[nH]c2sc(Cl)cc2c(NC2CCCNC2)c1-c1nc2ccccc2[nH]1 CHEMBL3330148 IC50 4.05 nM
CN1CCN(c2ccc(-c3cnc4[nH]c5cnc(C(=O)O)cc5c4c3)cc2)CC1 CHEMBL3359893 IC50 4.1 nM
COc1cc(OCCNCc2ccc(F)cc2)ccc1NC(=O)Nc1cnc(C#N)cn1 CHEMBL3694355 IC50 4.1 nM
C[C@@H]1C[C@H](C)CN(Cc2ccc(-c3cnc4[nH]c5cnc(C#N)cc5c4c3)cc2)C1 CHEMBL3582203 IC50 4.2 nM
O=c1[nH]c2ccc(-n3ccnc3)cc2cc1-c1cc2cc(CN3CCCCC3)ccc2[nH]1 CHEMBL218171 IC50 4.3 nM
NCCCc1cc2cc[nH]c(=O)c2c2cc(-c3ccn[nH]3)ccc12 CHEMBL400323 IC50 4.3 nM
NC(=O)c1cc2c(cn1)[nH]c1ncc(-c3ccc(CN4CCCCC4)cc3)cc12 CHEMBL3582218 IC50 4.3 nM
Oc1ccc(-c2ccc(-c3n[nH]c4c3Cc3cc(O)ccc3-4)cc2)cc1 CHEMBL391449 IC50 4.4 nM
CNc1cc(Nc2cnc(C#N)c(O[C@@H]3CCN(C)C3)n2)ncc1-c1cnn(C)c1 CHEMBL2203841 IC50 4.4 nM
CC1(C)CCN(Cc2ccc(-c3cnc4[nH]c5cnc(C#N)cc5c4c3)cc2)CC1 CHEMBL3582205 IC50 4.4 nM
CNc1nc(Nc2cnc(C#N)c(OC3CCCNC3)c2)ncc1-c1cccc(F)c1 CHEMBL4466434 IC50 4.49 nM
COc1cc(-c2ccc3c(c2)NC(=O)/C3=C\c2ccc(C(=O)NCCN3CCCC3)[se]2)ccc1O CHEMBL1223116 IC50 4.5 nM
O=C1Nc2cc(-c3ccc(O)cc3)ccc2/C1=C/c1ccc(C(=O)NCCN2CCCCO2)[se]1 CHEMBL1223340 IC50 4.5 nM
CC(=O)C1=NN(c2ccccc2)/C(=C2/S/C(=N\c3nc(-c4ccccc4)cc(-c4ccccc4)c3C#N)N(c3ccccc3)C2=O)S1 CHEMBL3408394 IC50 4.59 nM
N#Cc1ccc2[nH]c(=O)c(-c3cc4cc(CN5CCCCC5)ccc4[nH]3)cc2c1 CHEMBL415656 IC50 4.6 nM
CCN(CC)CCNC(=O)c1ccc(/C=C2\C(=O)Nc3cc(-c4ccc(O)cc4)ccc32)[se]1 CHEMBL1223338 IC50 4.6 nM
Cn1ncc2cc(-c3cnc(Nc4cnc(C#N)cn4)cc3NC[C@H]3CNCCO3)ccc21 CHEMBL4797851 IC50 4.6 nM
N#Cc1cnc(Nc2cc(NCC3CCNCC3)c(/C=C/CCO)cn2)cn1 CHEMBL4760882 IC50 4.7 nM
CNc1nc(Nc2cnc(C#N)c(OC3CCCNC3)c2)ncc1-c1nc(C)cs1 CHEMBL4580169 IC50 4.72 nM
CNc1nc(Nc2cnc(C#N)c(OC3CCCNC3)c2)ncc1-c1ccncc1 CHEMBL4482947 IC50 4.72 nM
COc1cc2c(cc1OCC1CCCCO1)Nc1cc(-c3ccc([N+](=O)[O-])c(OC)c3)ccc1C(=O)N2 CHEMBL272347 IC50 4.8 nM
COc1cc(-c2ccc3c(-c4cc5ccccc5[nH]4)n[nH]c3c2)ccc1O CHEMBL3891392 Ki 4.8 nM
O=c1[nH]c2sc(Br)cc2c(NC2CCCNC2)c1-c1nc2ccccc2[nH]1 CHEMBL3330230 IC50 4.83 nM
N#Cc1cnc(NC(=O)Nc2cc(Cl)ccc2OC2CCOCC2)cn1 CHEMBL426811 IC50 5.0 nM
N#Cc1ncc2nc1OCCCCCOc1cc(CC(O)CO)c(Cl)cc1NC(=O)N2 CHEMBL219637 IC50 5.0 nM
COCCOc1cc2c(cc1Cl)NC(=O)Nc1cnc(C#N)c(n1)OCCCCCO2 CHEMBL374334 IC50 5.0 nM
O=C(NCCO)c1ccc2c(c1)-c1[nH]nc(-c3ccc(-c4ccc(O)cc4)cc3)c1C2 CHEMBL232805 IC50 5.0 nM
N#Cc1ncc2nc1OC/C=C\COc1ccc(Cl)cc1NC(=O)N2 CHEMBL444365 IC50 5.0 nM
N#Cc1ncc2nc1OCC/C=C\COc1ccc(OCCCCCN3CCOCC3)cc1NC(=O)N2 CHEMBL238351 IC50 5.0 nM
N#Cc1ncc2nc1OCC/C=C\COc1ccc(OCCCN3CCOCC3)cc1NC(=O)N2 CHEMBL393569 IC50 5.0 nM
COc1cc2c(cc1OCCN1CCOCC1)-c1n[nH]c(-c3ccc(-c4ccc(O)cc4)cc3)c1C2 CHEMBL248212 IC50 5.0 nM
COc1cc2c(cc1O)-c1n[nH]c(-c3ccc(-c4ccc(O)cc4)cc3)c1C2 CHEMBL248200 IC50 5.0 nM
COc1cc2c(cc1OCCn1ccnc1)Cc1c-2n[nH]c1-c1ccc(-c2ccc(O)cc2)cc1 CHEMBL248011 IC50 5.0 nM
COc1cc2c(cc1OCCc1ccncc1)Cc1c-2n[nH]c1-c1ccc(-c2ccc(O)cc2)cc1 CHEMBL247824 IC50 5.0 nM
COc1cc(C#Cc2[nH]nc3c2Cc2cc(OC)c(OC)cc2-3)ccc1O CHEMBL248396 IC50 5.0 nM
CNCCCn1c2ccc(O)cc2c2c3c(c(-c4c(Cl)cccc4Cl)cc21)C(=O)NC3=O CHEMBL452336 IC50 5.0 nM
NC(=O)Nc1sc(-c2ccc(C(N)=O)cc2)cc1C(=O)N[C@H]1CCCNC1 CHEMBL519248 IC50 5.0 nM
NC(=O)Nc1sc(-c2cccc(C(N)=O)c2)cc1C(=O)N[C@H]1CCCNC1 CHEMBL470289 IC50 5.0 nM
NC(=O)c1cnc(N[C@H]2CCCNC2)c2cc(-c3cc(F)cc(F)c3)sc12 CHEMBL1288302 IC50 5.0 nM
NC(=O)c1cnc(N[C@H]2CCCNC2)c2cc(-c3cccnc3)sc12 CHEMBL1287919 IC50 5.0 nM
NC(=O)c1cnc(N[C@H]2CCCNC2)c2cc(-c3cccc4[nH]ccc34)sc12 CHEMBL1287949 IC50 5.0 nM
NC(=O)c1cnc(N[C@H]2CCCNC2)c2cc(-c3ccc(C(F)(F)F)cc3)sc12 CHEMBL1288132 IC50 5.0 nM
NC(=O)c1cnc(N[C@H]2CCCNC2)c2cc(-c3ccc(F)cc3)sc12 CHEMBL1288164 IC50 5.0 nM
NC(=O)c1cnc(N[C@H]2CCCNC2)c2cc(-c3ccc4ncccc4c3)sc12 CHEMBL1288279 IC50 5.0 nM
Cn1cc(-c2cnn3c(N)c(Br)c(C[C@H]4CCC[C@@H](N)C4)nc23)cn1 CHEMBL1643236 IC50 5.0 nM
CNCc1cc(-c2ccc3c(N)cc4n[nH]c(=O)n4c3c2)cs1 CHEMBL2012858 IC50 5.0 nM
c1cncc(-c2cncc(-c3cnc(Nc4cc(N5CCNCC5)ccn4)s3)c2)c1 CHEMBL2013067 IC50 5.0 nM
O=C(Nc1ccccc1N1CCNCC1)c1csc(-c2ccc(Oc3ccccc3)cc2)n1 CHEMBL2037096 IC50 5.0 nM
O=C(Nc1ccccc1N1CCNCC1)c1csc(-c2ccc3sccc3c2)n1 CHEMBL2037113 IC50 5.0 nM
NC(=O)Nc1cc(-c2cccc(F)c2)sc1C(=O)N[C@H]1CCCNC1 CHEMBL2041933 IC50 5.0 nM
COc1ccc2c(c1)C(=O)N(c1nc(C(=O)Nc3ccccc3N3CCNCC3)cs1)C2 CHEMBL2381248 IC50 5.0 nM
N#Cc1cc2c(cn1)[nH]c1ncc(-c3ccc(CN4CCC(F)CC4)cc3)cc12 CHEMBL3582209 IC50 5.0 nM
CCc1cc2c(cc1OC1CCOC1)Cc1c(-c3cccnc3)n[nH]c1-2 CHEMBL563792 pKi 5.012 nM
COc1cc2c(cc1OCCCN1CCOCC1)C(=O)c1c(-c3ccccc3)n[nH]c1-2 CHEMBL550820 pKi 5.012 nM
N#Cc1cnc(NC(=O)Nc2cc(Cl)ccc2N2CCC(O)C2)cn1 CHEMBL555940 pKi 5.012 nM
N#Cc1cnc(NC(=O)Nc2cc(Cl)ccc2OC2C[C@H](O)[C@@H](O)C2)cn1 CHEMBL550417 pKi 5.012 nM
N#Cc1ncc2nc1OCCCCCOc1cc(OCCO)c(Cl)cc1NC(=O)N2 CHEMBL413779 pKi 5.012 nM
c1ncc(-c2cc3c(cn2)[nH]c2ncc(-c4ccc(CN5CCCCC5)cc4)cc23)cn1 CHEMBL3582232 IC50 5.1 nM
COc1cc(CCN[C@@H](C)c2ccc(F)cc2)ccc1NC(=O)Nc1cnc(C#N)cn1 CHEMBL3694377 IC50 5.1 nM
C[C@H](O)C(=O)N1CCc2cc(Nc3ncc(C(F)(F)F)c(N[C@H]4CC[C@@H](N)CC4)n3)ccc2C1 CHEMBL5428756 IC50 5.1 nM
CN(C)CCNCc1ccc2c(c1)-c1[nH]nc(-c3ccc(-c4ccc(O)cc4)cc3)c1C2 CHEMBL234867 IC50 5.2 nM
COc1cc(-c2ccc3c(/C=C/c4ccc(OC)c(OC)c4)n[nH]c3c2)ccc1O CHEMBL3923888 Ki 5.2 nM
N#Cc1cnc(Nc2cc(NC[C@H]3CNCCO3)c(-c3cccc(Cl)c3)cn2)cn1 CHEMBL4742116 IC50 5.2 nM
C#Cc1cnc(Nc2cnc(C#N)cn2)cc1NC[C@@H]1CNCCO1 CHEMBL4740741 IC50 5.2 nM
O=c1[nH]c2sccc2c(N[C@H]2CCCNC2)c1-c1nc2ccccc2[nH]1 CHEMBL3330133 IC50 5.22 nM
N#Cc1cc2c(cn1)[nH]c1ncc(-c3ccc(CN4CCCCC4)nc3)cc12 CHEMBL3582213 IC50 5.3 nM
COc1ccc2[nH]c(-c3c(NC4CN5CCC4CC5)c4cc(Cl)sc4[nH]c3=O)nc2c1 CHEMBL3330233 IC50 5.36 nM
CNc1cc(Nc2cnc(C#N)c(O[C@@H]3CCNC3)n2)ncc1C(=O)OC CHEMBL2203848 IC50 5.4 nM
CC(=O)Nc1cccc2c1Cc1c(-c3ccc(-c4ccc(O)cc4)cc3)n[nH]c1-2 CHEMBL232391 IC50 5.5 nM
O=c1[nH]c2ccc(-c3cc[nH]n3)cc2cc1-c1cc2cc(CN3CCCCC3)ccc2[nH]1 CHEMBL221496 IC50 5.6 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)N[C@H]4O CHEMBL574737 IC50 5.6 nM
N#Cc1ccc(-c2n[nH]c3c2Cc2ccc(OCCN4CCOCC4)cc2-3)cn1 CHEMBL249282 IC50 5.9 nM
O=C1Nc2cc(-c3ccc(O)cc3)ccc2/C1=C/c1ccc(C(=O)NCCN2CCCC2)[se]1 CHEMBL1223339 IC50 5.9 nM
N#Cc1ncc2nc1OCCCCCOc1cc(NCc3cncs3)c(Cl)cc1NC(=O)N2 CHEMBL223347 IC50 6.0 nM
CCOc1cc2c(cc1Cl)NC(=O)Nc1cnc(C#N)c(n1)OCCCCCO2 CHEMBL223311 IC50 6.0 nM
N#Cc1ncc2nc1OCCCCCOc1cc(O)c(Cl)cc1NC(=O)N2 CHEMBL375644 IC50 6.0 nM
N#Cc1ncc2nc1OCCCCOc1ccc(Cl)cc1NC(=O)N2 CHEMBL375097 IC50 6.0 nM
COc1cc(-c2ccc3c(c2)Nc2cc(CC(=O)N(C)C)ccc2NC3=O)ccc1N CHEMBL437384 IC50 6.0 nM
COc1cc(-c2ccc3c(c2)Nc2ccc(CC(=O)N(C)C)cc2NC3=O)ccc1N CHEMBL243934 IC50 6.0 nM
COc1cc(-c2ccc3c(c2)Nc2cc(N)ccc2NC3=O)ccc1N CHEMBL243500 IC50 6.0 nM
O=C(O)c1ccc(-c2n[nH]c3c2Cc2cc(CN[C@H]4CC[C@H](O)CC4)ccc2-3)cc1 CHEMBL242521 IC50 6.0 nM
N#Cc1ncc2nc1OCC/C=C\COc1ccc(OCCCCN3CCOCC3)cc1NC(=O)N2 CHEMBL238145 IC50 6.0 nM
COc1cc2c(cc1OCCCN1CCOCC1)Cc1c-2n[nH]c1-c1ccc(-c2ccc(O)cc2)cc1 CHEMBL247460 IC50 6.0 nM
COc1cc2c(cc1OC[C@H](O)CO)Cc1c-2n[nH]c1-c1ccc(C#N)cc1 CHEMBL399532 IC50 6.0 nM
N#Cc1ccc(-c2[nH]nc3c2Cc2cc(C(=O)N[C@H]4CC[C@H](O)CC4)ccc2-3)cc1 CHEMBL401326 IC50 6.0 nM
N#Cc1ncc2nc1OCCCCOc1cc(N3CCOC3=O)c(Cl)cc1NC(=O)N2 CHEMBL248953 IC50 6.0 nM
N#Cc1ncc2nc1OC/C=C\COc1cc(NC(=O)c3ccnc(Cl)c3)c(Cl)cc1NC(=O)N2 CHEMBL249972 IC50 6.0 nM
N#Cc1ncc2nc1OC/C=C\COc1cc(NC(=O)c3ccncc3)c(Cl)cc1NC(=O)N2 CHEMBL398875 IC50 6.0 nM
NC(=O)Nc1sc(-c2cccnc2)cc1C(=O)N[C@H]1CCCNC1 CHEMBL488230 IC50 6.0 nM
NC(=O)Nc1sc(-c2ccsc2)cc1C(=O)N[C@H]1CCCNC1 CHEMBL520734 IC50 6.0 nM
CS(=O)(=O)c1ccc(-c2cc(C(=O)N[C@H]3CCCNC3)c(NC(N)=O)s2)cc1 CHEMBL520902 IC50 6.0 nM
N#Cc1ccc(-c2cc(C(=O)N[C@H]3CCCNC3)c(NC(N)=O)s2)cc1 CHEMBL469481 IC50 6.0 nM
Cc1cc2n[nH]c(=O)n2c2cc(-c3ccc(CN4CCNCC4)cc3)ccc12 CHEMBL1223320 IC50 6.0 nM
Cn1cc(-c2cnn3c(N)c(Br)c(C4CNCCS4)nc23)cn1 CHEMBL1643230 IC50 6.0 nM
Nc1cc2n[nH]c(=O)n2c2cc(-c3ccsc3)ccc12 CHEMBL2012857 IC50 6.0 nM
Cn1cc(-c2cncc(-c3cnc(Nc4cc(N5CCNCC5)ccn4)s3)c2)cn1 CHEMBL2013066 IC50 6.0 nM
OCC#Cc1cncc(-c2cnc(Nc3cc(N4CCOCC4)ccn3)s2)c1 CHEMBL2011343 IC50 6.0 nM
N#Cc1ccc(-c2cc(NC(N)=O)c(C(=O)N[C@H]3CCCNC3)s2)cc1 CHEMBL2070714 IC50 6.0 nM
N#Cc1ccc(-c2cc(C(=O)N[C@H]3CCCNC3)c(NC(N)=O)s2)cc1 CHEMBL2070713 IC50 6.0 nM
NC(=O)Nc1cc(-c2ccc(F)cc2)sc1C(=O)N[C@H]1CCCNC1 CHEMBL2070702 IC50 6.0 nM
COc1cc(Nc2cnc(C#N)c(O[C@H](C)CN(C)C)n2)ncc1-c1cnn(C)c1 CHEMBL2203843 IC50 6.0 nM
Cn1cc(-c2cc3c(N[C@H]4CCCNC4)ncc(C(N)=O)c3s2)cn1 CHEMBL4066751 IC50 6.0 nM
NC(=O)c1cnc(N[C@H]2CCCNC2)c2cc(-c3ccsc3)sc12 CHEMBL4079910 IC50 6.0 nM
C[C@H]1NCCC[C@@H]1Nc1ncc(C(N)=O)c2sc(-c3ccccc3)cc12 CHEMBL4059912 IC50 6.0 nM
C[C@H](CN(C)C)Oc1nc(Nc2cc3cccc(Cl)c3cn2)cnc1C#N CHEMBL1928705 IC50 6.1 nM
O=C(N[C@H]1CC[C@H](O)CC1)c1ccc2c(c1)Cc1c(-c3ccc(-c4ccc(O)cc4)cc3)n[nH]c1-2 CHEMBL438485 IC50 6.2 nM
O=c1[nH]c2sc(Cl)cc2c(NC2CN3CCC2CC3)c1-c1nc2ccccc2[nH]1 CHEMBL3330229 IC50 6.23 nM
COc1cc(Nc2cnc(C#N)c(O[C@@H]3CCN(C)C3)n2)ncc1-c1cnn(C)c1 CHEMBL2203845 IC50 6.3 nM
COc1cc(-c2ccc3c(c2)Nc2ccc(C(C)(C)C(=O)Nc4ccc(N5CCOCC5)cc4)cc2NC3=O)ccc1[N+](=O)[O-] CHEMBL540992 pKi 6.31 nM
N#Cc1cnc(NC(=O)Nc2cc(Cl)ccc2OC2CCC(O)C2)cn1 CHEMBL549660 pKi 6.31 nM
COc1cc(-c2ccc3c(c2)Nc2ccc(CC(=O)N(C)C)cc2NC3=O)ccc1[N+](=O)[O-] CHEMBL562875 pKi 6.31 nM
COc1cccc(-c2ccc3c(c2)Nc2cc(OCc4ccncc4)c(OC)cc2NC3=O)c1 CHEMBL559498 pKi 6.31 nM
N#Cc1ncc2nc1OCC(O)C(O)COc1ccc(Cl)cc1NC(=O)N2 CHEMBL1980802 pKi 6.31 nM
Cn1nnc(-c2ccc3[nH]c(=O)c(-c4cc5cc(CN6CCCCC6)ccc5[nH]4)cc3c2)n1 CHEMBL221603 IC50 6.4 nM
O=C(CNCc1ccncc1)Nc1ccc2c(c1)Cc1c(-c3ccc(-c4ccc(O)cc4)cc3)n[nH]c1-2 CHEMBL234482 IC50 6.4 nM
Cc1ncsc1CCOc1ccc2c(c1)-c1[nH]nc(-c3ccc(C#N)nc3)c1C2 CHEMBL249077 IC50 6.4 nM
N#Cc1ccc(-c2n[nH]c3c2Cc2cc(OCCCN4CCOCC4)ccc2-3)cn1 CHEMBL249324 IC50 6.4 nM
COc1cc(CCNCc2ccc(F)cc2F)ccc1NC(=O)Nc1cnc(C#N)cn1 CHEMBL3694363 IC50 6.4 nM
COc1ccc(-c2cnc(Nc3cnc(C#N)cn3)cc2NC[C@H]2CNCCO2)cc1 CHEMBL4761664 IC50 6.4 nM
N#Cc1cnc(Nc2cc(NC[C@H]3CNCCO3)c(-c3cccc(F)c3)cn2)cn1 CHEMBL4741023 IC50 6.4 nM
CNc1nc(Nc2cnc(C#N)c(OCC3CCNCC3)c2)ncc1-c1cnn(C)c1 CHEMBL4554563 IC50 6.44 nM
N#Cc1ccc(-c2n[nH]c3c2Cc2cc(OCCN4CCOCC4)ccc2-3)cn1 CHEMBL400570 IC50 6.5 nM
NCCCc1cc2cc[nH]c(=O)c2c2cc(-c3ccc(CN)cc3)ccc12 CHEMBL249236 IC50 6.5 nM
OCCNCc1ccc2c(c1)Cc1c(-c3ccc(-c4ccc(O)cc4)cc3)n[nH]c1-2 CHEMBL389378 IC50 6.6 nM
COc1cc(-c2ccc3c(/C=C/c4ccc(NC(=O)CN)cc4)n[nH]c3c2)ccc1O CHEMBL3919791 Ki 6.6 nM
COc1cc(-c2ccc3c(c2)Nc2ccc(C(C)(C)C(=O)Nc4ccc(N5CCOCC5)cc4)cc2NC3=O)ccc1N CHEMBL389745 IC50 6.7 nM
COc1cc2c(cc1OCc1ccncc1)Nc1cc(-c3ccc([N+](=O)[O-])c(OC)c3)ccc1C(=O)N2 CHEMBL257512 IC50 6.8 nM
CNc1nc(Nc2cnc(C#N)c(O[C@@H]3CCCNC3)c2)ncc1-c1cnn(C(F)(F)F)c1 CHEMBL4856792 IC50 6.8 nM
CC1(COc2ccc(Cl)cc2NC(=O)Nc2cnc(C#N)cn2)COC1 CHEMBL192161 IC50 7.0 nM
COc1cc(-c2ccc3c(c2)NC(=O)/C3=C\c2ccc[nH]2)ccc1O CHEMBL202930 IC50 7.0 nM
COc1cc(OC)c(NC(=O)Nc2cnc(C#N)cn2)cc1Cl CHEMBL207994 IC50 7.0 nM
COc1cc(NC(=O)Cc2ccc(S(C)(=O)=O)cc2)c(Cl)cc1NC(=O)Nc1cnc(C#N)cn1 CHEMBL206460 IC50 7.0 nM
CN(C)c1cc2c(cc1Cl)NC(=O)Nc1cnc(C#N)c(n1)OCCCCCO2 CHEMBL387341 IC50 7.0 nM
N#Cc1ncc2nc1OCCCCCOc1cc(NCc3cnco3)c(Cl)cc1NC(=O)N2 CHEMBL374416 IC50 7.0 nM
N#Cc1ncc2nc1OCCCCCOc1ccc(Cl)cc1NC(=O)N2 CHEMBL220002 IC50 7.0 nM
CC(=O)Nc1cc2c(cc1Cl)NC(=O)Nc1cnc(C#N)c(n1)OCCCCCO2 CHEMBL223255 IC50 7.0 nM
COc1cc(-c2ccc3c(c2)Nc2ccc(CC(=O)Nc4ccc(N5CCOCC5)cc4)cc2NC3=O)ccc1N CHEMBL395080 IC50 7.0 nM
N#Cc1ncc2nc1OCCCCCOc1ccc(OCCCN3CCOCC3)cc1NC(=O)N2 CHEMBL235368 IC50 7.0 nM
N#Cc1ccc(-c2n[nH]c3c2Cc2ccc(NCCN4CCOCC4)cc2-3)cn1 CHEMBL249115 IC50 7.0 nM
COc1cc2c(cc1OC)-c1n[nH]c(-c3ccc(C#N)cc3)c1C2 CHEMBL395894 IC50 7.0 nM
Cn1c2cc([S+]([O-])CCCN3CCCC3)c(O)cc2c2c3c(c(-c4ccccc4Cl)cc21)C(=O)NC3=O CHEMBL270866 IC50 7.0 nM
NC(=O)Nc1sc(-c2ccccc2)cc1C(=O)N[C@H]1CCCNC1 CHEMBL487273 IC50 7.0 nM
CC(=O)c1ccc(-c2cc(C(=O)N[C@H]3CCCNC3)c(NC(N)=O)s2)cc1 CHEMBL488044 IC50 7.0 nM
NC(=O)Nc1sc(-c2ccc(O)cc2)cc1C(=O)N[C@H]1CCCNC1 CHEMBL459428 IC50 7.0 nM
Cc1cc2n[nH]c(=O)n2c2cc(-c3cccc(CN4CCNCC4)c3)ccc12 CHEMBL1223321 IC50 7.0 nM
CNCCNc1ncc(C(N)=O)c2sc(-c3ccc(Cl)cc3)cc12 CHEMBL1288191 IC50 7.0 nM
N#Cc1cccc(-c2cc3c(N[C@H]4CCCNC4)ncc(C(N)=O)c3s2)c1 CHEMBL1288163 IC50 7.0 nM
Cn1cc(-c2cnn3c(N)c(Br)c(CC4CCNC4)nc23)cn1 CHEMBL1643234 IC50 7.0 nM
Cn1cc(-c2cnn3c(N)c(Br)c(CC4CCCNC4)nc23)cn1 CHEMBL1643235 IC50 7.0 nM
N#Cc1ncc(Nc2cc3ccccc3cn2)nc1OC1CCCNC1 CHEMBL1928700 IC50 7.0 nM
CNC(=O)c1cncc(-c2cnc(Nc3cc(N4CCOCC4)ccn3)s2)c1 CHEMBL2013159 IC50 7.0 nM
O=C(Nc1ccccc1N1CCNCC1)c1csc(-c2cc3ccccc3s2)n1 CHEMBL2037114 IC50 7.0 nM
N#Cc1cccc(-c2cc(NC(N)=O)c(C(=O)N[C@H]3CCCNC3)s2)c1 CHEMBL2070716 IC50 7.0 nM
CNc1cc(Nc2cnc(C#N)c(O[C@H](C)CN(C)C)n2)ncc1C(=O)OC CHEMBL2203847 IC50 7.0 nM
O=C(Nc1cnccc1N1CCNCC1)c1csc(-c2ccc3sccc3c2)n1 CHEMBL2381111 IC50 7.0 nM
COC(=O)c1ccc2c(c1)/C(=C(/Nc1ccc(N(C)C(=O)CN3CCN(C)CC3)cc1)c1ccccc1)C(=O)N2 CHEMBL4062168 Ki 7.0 nM
Cc1cn2c(-c3cn[nH]c3)cnc2c(Nc2cc(C(NC(C)(C)C)c3ccccn3)ns2)n1 CHEMBL4225923 IC50 7.0 nM
COC(=O)c1cnc(Nc2cnc(C#N)cn2)cc1NC[C@H]1C[C@H]2CC[C@@H](C1)N2C CHEMBL4756720 IC50 7.0 nM
Oc1ccc(-c2ccc(-c3n[nH]c4c3Cc3ccc(CNCCN5CCCC5)cc3-4)cc2)cc1 CHEMBL393603 IC50 7.1 nM
Oc1nc2ccc(Cl)cc2c(N[C@@H]2CCNC2)c1-c1nc2ccccc2[nH]1 CHEMBL210035 IC50 7.2 nM
Cc1cnc(CNCc2ccc3c(c2)Cc2c(-c4ccc(-c5ccc(O)cc5)cc4)n[nH]c2-3)cn1 CHEMBL242536 IC50 7.4 nM
N#Cc1cnc(Nc2cc(NC[C@@H]3CNCCO3)c(C3CC3)cn2)cn1 CHEMBL4792322 IC50 7.4 nM
COc1cccc(CNCc2ccc(NC(=O)Nc3cnc(C#N)cn3)c(OC)c2)c1 CHEMBL3694394 IC50 7.5 nM
O=c1[nH]c2ccsc2c(NC2CCCNC2)c1-c1nc2ccccc2[nH]1 CHEMBL3330236 IC50 7.54 nM
Oc1nc2ccccc2c(N[C@@H]2CN3CCC2CC3)c1-c1nc2ccccc2[nH]1 CHEMBL377554 IC50 7.6 nM
CN(C)CCNC(=O)c1ccc(/C=C2\C(=O)Nc3cc(-c4ccc(O)cc4)ccc32)[se]1 CHEMBL1223337 IC50 7.6 nM
N#Cc1c(-c2ccccc2)cc(-c2ccccc2)nc1/N=c1\scc(-c2ccccc2)n1-c1ccccc1 CHEMBL3408392 IC50 7.6 nM
CNc1nc(Nc2cnc(C#N)c(O[C@@H]3CCCNC3)c2)ncc1C(F)(F)F CHEMBL4860336 IC50 7.6 nM
CC(=O)N1CCc2cc(Nc3ncc(C(F)(F)F)c(N[C@H]4CC[C@@H](N)CC4)n3)ccc2C1 CHEMBL5409504 IC50 7.6 nM
N[C@H]1CC[C@@H](Nc2nc(Nc3ccc4c(c3)CN(C(=O)CO)C4)ncc2C(F)(F)F)CC1 CHEMBL5426241 IC50 7.6 nM
CC(=O)N1CCc2ccc(Nc3ncc(C(F)(F)F)c(N[C@H]4CC[C@@H](N)CC4)n3)cc2C1 CHEMBL5421825 IC50 7.61 nM
OCc1ccc2c(c1)Cc1c(-c3ccc(-c4ccc(O)cc4)cc3)n[nH]c1-2 CHEMBL391450 IC50 7.7 nM
OCc1cccc2c1Cc1c(-c3ccc(-c4ccc(O)cc4)cc3)n[nH]c1-2 CHEMBL232392 IC50 7.8 nM
COc1ccccc1CNCc1ccc(NC(=O)Nc2cnc(C#N)cn2)c(OC)c1 CHEMBL3694395 IC50 7.8 nM
O=C(O)c1ccc(-c2n[nH]c3c2Cc2cc(CN4CCOCC4)ccc2-3)cc1 CHEMBL389780 IC50 7.9 nM
COc1cc2c(cc1CCC(=O)N(C)C)Nc1cc(-c3ccc([N+](=O)[O-])c(OC)c3)ccc1C(=O)N2 CHEMBL272711 IC50 7.9 nM
N#Cc1cnc(NC(=O)Nc2ccc(CCNCc3ccc(F)c(F)c3)c(Cl)c2)cn1 CHEMBL3694373 IC50 7.9 nM
COC(=O)Cc1ccc2c(c1)NC(=O)c1ccc(-c3cc(OC)ncc3C)cc1N2 CHEMBL549313 pKi 7.943 nM
O=C1Nc2cncc(n2)OCCCCCOc2ccc(Cl)cc2N1 CHEMBL223512 pKi 7.943 nM
CN[C@@H]1C[C@@H]2O[C@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL364347 pKi 7.943 nM
CC(CN(C)C)Oc1ccc(Cl)cc1NC(=O)Nc1cnc(C#N)cn1 CHEMBL425904 IC50 8.0 nM
COc1cc(NC(=O)c2ccncc2)c(Cl)cc1NC(=O)Nc1cnc(C#N)cn1 CHEMBL208332 IC50 8.0 nM
Cc1ccc2c(c1)NC(=O)Nc1cnc(C#N)c(n1)OCCCCCO2 CHEMBL236644 IC50 8.0 nM
CC(=O)Nc1ccc2c(c1)NC(=O)Nc1cnc(C#N)c(n1)OCCCCCO2 CHEMBL236230 IC50 8.0 nM
COc1cc2c(cc1OCc1ccncc1)Cc1c-2n[nH]c1-c1ccc(-c2ccc(O)cc2)cc1 CHEMBL400665 IC50 8.0 nM
COc1cc2c(cc1OCCCN1CCN(c3cccc(Cl)c3)CC1)Cc1c-2n[nH]c1-c1ccc(-c2ccc(O)cc2)cc1 CHEMBL247821 IC50 8.0 nM
N#Cc1ncc2nc1OCCCCOc1cc(OCCO)c(Cl)cc1NC(=O)N2 CHEMBL249155 IC50 8.0 nM
N#Cc1ncc2nc1OCCCCOc1cc(P(=O)(O)O)c(Cl)cc1NC(=O)N2 CHEMBL249154 IC50 8.0 nM
CC(=O)Nc1cccc(-c2cc(C(=O)N[C@H]3CCCNC3)c(NC(N)=O)s2)c1 CHEMBL504542 IC50 8.0 nM
O=C1Nc2cc(-c3ccc(O)cc3)ccc2/C1=C/c1ccc(C(=O)NCCCn2ccnc2)[se]1 CHEMBL1223406 IC50 8.0 nM
Cn1ccc2cc(-c3cc4c(N[C@H]5CCCNC5)ncc(C(N)=O)c4s3)ccc21 CHEMBL1288304 IC50 8.0 nM
Cc1ncc(-c2cnn3c(N)c(Br)c(C4CCCNC4)nc23)s1 CHEMBL1643225 IC50 8.0 nM
c1cc(N2CCNCC2)cc(Nc2ncc(-c3cncc(-c4cn[nH]c4)c3)s2)n1 CHEMBL2011349 IC50 8.0 nM
NCCNC(=O)c1cccc(-c2cnc(Nc3cc(N4CCC(F)(F)CC4)ccn3)s2)c1 CHEMBL2013163 IC50 8.0 nM
NC(=O)Nc1cc(-c2cccc(Cl)c2)sc1C(=O)N[C@H]1CCCNC1 CHEMBL2070704 IC50 8.0 nM
O=C(Nc1cnccc1N1CCNCC1)c1csc(N2Cc3ccccc3C2)n1 CHEMBL2381114 IC50 8.0 nM
O=C(Nc1ccccc1N1CCNCC1)c1csc(N2Cc3ccccc3C2)n1 CHEMBL2381238 IC50 8.0 nM
COc1cc2c(cc1OCCN1CCOCC1)Nc1cc(-c3ccc([N+](=O)[O-])c(OC)c3)ccc1C(=O)N2 CHEMBL411098 IC50 8.1 nM
COc1ccc(-c2cnc(Nc3cnc(C#N)c(OC4CCCNC4)c3)nc2)cc1 CHEMBL4457287 IC50 8.34 nM
COc1cc(OCCNCc2ccc(F)cc2)c(Cl)cc1NC(=O)Nc1cnc(C#N)cn1 CHEMBL3694380 IC50 8.4 nM
Cn1cc2cc(-c3cnc(Nc4cnc(C#N)cn4)cc3NC[C@H]3CNCCO3)ccc2n1 CHEMBL4740334 IC50 8.5 nM
CNc1nc(Nc2cnc(C#N)c(N[C@H]3CC[C@@H](N)CC3)c2)ncc1C(F)(F)F CHEMBL4860628 IC50 8.5 nM
CC(C)(O)C(=O)N1CCc2cc(Nc3ncc(C(F)(F)F)c(N[C@H]4CC[C@@H](N)CC4)n3)ccc2C1 CHEMBL5431016 IC50 8.6 nM
CNc1nc(Nc2cnc(C#N)c(OC3CCCNC3)c2)ncc1-c1ccc(F)cc1 CHEMBL4542788 IC50 8.76 nM
COc1cc(-c2ccc3c(c2)NC(=O)/C3=C\c2ccc(C(=O)NCCN3CCOCC3)[se]2)ccc1O CHEMBL1223117 IC50 8.8 nM
COC(=O)c1cnc(Nc2cnc(C#N)c(O[C@@H]3CCNC3)n2)cc1N(C)C CHEMBL2204583 IC50 8.8 nM
CCNC(=O)c1cnc(Nc2cnc(C#N)cn2)cc1NCC1CCNCC1 CHEMBL4750202 IC50 8.8 nM
CNc1nc(Nc2cnc(C#N)c(O[C@H]3CCCNC3)c2)ncc1-c1cnn(C)c1 CHEMBL4517983 IC50 8.88 nM
COc1cc(CNCc2ccc(F)cc2)ccc1NC(=O)Nc1cnc(C#N)cn1 CHEMBL3694390 IC50 8.9 nM
COc1cc(NC(=O)Cc2cccnc2)c(Cl)cc1NC(=O)Nc1cnc(C#N)cn1 CHEMBL379095 IC50 9.0 nM
COc1cc(NC(=O)COC(C)=O)c(Cl)cc1NC(=O)Nc1cnc(C#N)cn1 CHEMBL207606 IC50 9.0 nM
N#Cc1ncc2nc1OCCCCCOc1cc(OCc3cccnc3)c(Cl)cc1NC(=O)N2 CHEMBL222413 IC50 9.0 nM
COCCOCCOc1cc2c(cc1Cl)NC(=O)Nc1cnc(C#N)c(n1)OCCCCCO2 CHEMBL376037 IC50 9.0 nM
COc1cc2c(cc1OCCc1ncsc1C)Cc1c-2n[nH]c1-c1ccc(C#N)cc1 CHEMBL247394 IC50 9.0 nM
CCc1cc2c(cc1OC)Nc1cc(-c3ccc([N+](=O)[O-])c(OC)c3)ccc1C(=O)N2 CHEMBL257317 IC50 9.0 nM
CN(C)C(=O)c1ccc(-c2cc(C(=O)N[C@H]3CCCNC3)c(NC(N)=O)s2)cc1 CHEMBL527881 IC50 9.0 nM
CNC(=O)c1ccc(-c2cc(C(=O)N[C@H]3CCCNC3)c(NC(N)=O)s2)cc1 CHEMBL487622 IC50 9.0 nM
NC(=O)Nc1sc(-c2ccc(F)cc2)cc1C(=O)N[C@H]1CCCNC1 CHEMBL516784 IC50 9.0 nM
NC(=O)Nc1sc(-c2ccccc2F)cc1C(=O)N[C@H]1CCCNC1 CHEMBL459631 IC50 9.0 nM
Cc1cc2n[nH]c(=O)n2c2cc(-c3ccc(CN4CCN(C)CC4)cc3)ccc12 CHEMBL1223386 IC50 9.0 nM
Cc1cc2n[nH]c(=O)n2c2cc(-c3ccc(CN4CCOCC4)cc3)ccc12 CHEMBL1223387 IC50 9.0 nM
NC(=O)c1cnc(N[C@H]2CCCNC2)c2cc(-c3ccc(F)cc3F)sc12 CHEMBL1288102 IC50 9.0 nM
NC(=O)c1cnc(N[C@H]2CCCNC2)c2cc(-c3ccc(Cl)c(F)c3)sc12 CHEMBL1288103 IC50 9.0 nM
NC(=O)c1cnc(N[C@H]2CCCNC2)c2cc(-c3ccc(OC(F)(F)F)cc3)sc12 CHEMBL1288193 IC50 9.0 nM
NC(=O)c1cnc(N[C@H]2CCCNC2)c2nc(-c3ccc(Cl)cc3)sc12 CHEMBL1287922 IC50 9.0 nM
Cc1cc(Nc2cc(C3CCCNC3)nc3c(-c4cnn(C)c4)cnn23)sn1 CHEMBL1643206 IC50 9.0 nM
CNCc1cc(-c2ccc3c(C(=O)NCCN(C)C)cc4n[nH]c(=O)n4c3c2)cs1 CHEMBL2012852 IC50 9.0 nM
c1cn(-c2cncc(-c3cnc(Nc4cc(N5CCOCC5)ccn4)s3)c2)nn1 CHEMBL2013065 IC50 9.0 nM
N#Cc1cccc(-c2cc(C(=O)N[C@H]3CCCNC3)c(NC(N)=O)s2)c1 CHEMBL2070715 IC50 9.0 nM
NC(=O)Nc1sc(-c2ccc(F)cc2)cc1C(=O)N[C@H]1CCCNC1 CHEMBL2070701 IC50 9.0 nM
NC(=O)Nc1sc(-c2ccccc2F)cc1C(=O)N[C@H]1CCCNC1 CHEMBL2070698 IC50 9.0 nM
NC(=O)c1ccc(N[C@H]2CCCNC2)c2cc(-c3cccc(F)c3)[nH]c12 CHEMBL4067770 IC50 9.0 nM
c1cc(-c2cc3c(cn2)[nH]c2ncc(-c4ccc(CN5CCCCC5)cc4)cc23)ccn1 CHEMBL3582229 IC50 9.1 nM
CN1CCN(c2cccc(CNCCc3ccc(NC(=O)Nc4cnc(C#N)cn4)cc3Cl)c2)CC1 CHEMBL3694371 IC50 9.1 nM
Cn1cc(-c2ccc3c(CCCN)cc4cc[nH]c(=O)c4c3c2)cn1 CHEMBL428580 IC50 9.2 nM
O=C(NCc1ccccn1)c1ccc2c(c1)Cc1c(-c3ccc(-c4ccc(O)cc4)cc3)n[nH]c1-2 CHEMBL234479 IC50 9.3 nM
CC1(C)CCCN(Cc2ccc(-c3cnc4[nH]c5cnc(C#N)cc5c4c3)cc2)C1 CHEMBL3582204 IC50 9.4 nM
COc1cc(CNCc2ccc(F)cc2)c(Cl)cc1NC(=O)Nc1cnc(C#N)cn1 CHEMBL3694396 IC50 9.8 nM
CC(C)(O)CC(=O)N1CCc2cc(Nc3ncc(C(F)(F)F)c(N[C@H]4CC[C@@H](N)CC4)n3)ccc2C1 CHEMBL5403690 IC50 9.8 nM
Cc1cc2c(NC3CCCNC3)c(-c3nc4ccccc4[nH]3)c(=O)[nH]c2s1 CHEMBL3330234 IC50 9.84 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)N[C@@H]4O CHEMBL1236539 IC50 9.88 nM
CN(C)CC(=O)N1CCC(c2ccc(NC(=O)c3nc(C#N)c[nH]3)c(C3=CCCCC3)c2)CC1 CHEMBL1908395 Kd 9.9 nM
N#Cc1c(-c2ccccc2)cc(-c2ccccc2)nc1/N=c1\sc(-c2ccccc2)nn1-c1ccccc1 CHEMBL3408382 IC50 9.9 nM
CC(C)(O)CC(=O)N1CCc2ccc(Nc3ncc(C(F)(F)F)c(N[C@H]4CC[C@@H](N)CC4)n3)cc2C1 CHEMBL5427417 IC50 9.9 nM
O=c1[nH]c2sccc2c(NC2CCNCC2)c1-c1nc2ccccc2[nH]1 CHEMBL3330135 IC50 9.94 nM