Nc1ncnc2scc(C(=O)Nc3ccc(NC(=O)Nc4ccccc4)cc3)c12 CHEMBL1988594 pKi 0.631 nM
COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 CHEMBL509032 pKi 1.259 nM
Cc1cc(C)cc(NC(=O)Nc2ccc(NC(=O)c3csc4ncnc(N)c34)cc2)c1 CHEMBL1970203 pKi 1.585 nM
NC(=O)c1ccc2[nH]c(-c3ccc(Sc4ccc(O)cc4)cc3)nc2c1 CHEMBL195041 IC50 2.0 nM
Cc1cc(Nc2ncc(F)c(NC3C4C=CC(C4)C3C(N)=O)n2)ccc1N1CCN(C)CC1 CHEMBL1967878 pKi 2.512 nM
COc1cc2nc(-c3cc(F)ccc3O)nc(N[C@@H]3CNC[C@H]3C(C)(C)O)c2cc1OC CHEMBL1236782 IC50 3.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(Oc4ccc(Cl)c(C(F)(F)F)c4)cc3)nc2c1 CHEMBL179717 IC50 3.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(S(=O)(=O)Nc4ccc(Cl)c(Cl)c4)cc3)nc2c1 CHEMBL195177 IC50 3.0 nM
C=C(c1ccc(Cl)cc1)c1ccc(-c2nc3cc(C(N)=O)ccc3[nH]2)cc1 CHEMBL3980850 IC50 3.0 nM
Cc1ccccc1NC(=O)Nc1ccc(NC(=O)c2csc3ncnc(N)c23)cc1 CHEMBL1980144 pKi 3.162 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL388978 IC50 3.34 nM
Cc1ccc(Oc2ccc(-c3nc4cc(C(N)=O)ccc4[nH]3)cc2)cc1Cl CHEMBL359881 IC50 4.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(Sc4ccc(F)c(Cl)c4)cc3)nc2c1 CHEMBL3958697 IC50 4.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(Oc4ccc(Br)c(O)c4)cc3)nc2c1 CHEMBL3894962 IC50 4.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(Cc4ccc(Cl)cc4)cc3)nc2c1 CHEMBL3949796 IC50 4.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(C(O)c4ccc(Cl)c(C(F)(F)F)c4)cc3)nc2c1 CHEMBL3935794 IC50 4.0 nM
COCCOc1cc2nc(-c3cc(F)ccc3O)nc(N[C@@H]3CNC[C@H]3C(C)(C)O)c2cc1OC CHEMBL1650128 IC50 5.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(Oc4ccc(Cl)c(Cl)c4)cc3)nc2c1 CHEMBL175553 IC50 5.0 nM
COc1ccc(Sc2ccc(-c3nc4cc(C(N)=O)ccc4[nH]3)cc2)cc1 CHEMBL3917001 IC50 5.0 nM
COc1cc(Oc2ccc(-c3nc4cc(C(N)=O)ccc4[nH]3)cc2)ccc1Br CHEMBL3956891 IC50 5.0 nM
Cc1ccc(Cc2ccc(-c3nc4cc(C(N)=O)ccc4[nH]3)cc2)cc1C CHEMBL3904143 IC50 5.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(Cc4ccc5ccccc5c4)cc3)nc2c1 CHEMBL3947096 IC50 5.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(C(O)c4ccc5ccccc5c4)cc3)nc2c1 CHEMBL3933085 IC50 5.0 nM
CC(c1ccc(Cl)cc1)c1ccc(-c2nc3cc(C(N)=O)ccc3[nH]2)cc1 CHEMBL3930129 IC50 5.0 nM
COc1cc2ncc(-c3cccc(NC4CCNC4)n3)n2cc1-c1cnn(C)c1 CHEMBL5176837 IC50 5.1 nM
Cc1nn(-c2ccccc2)c(Oc2ccc(-c3nc4cc(C(=O)NCc5ccccc5)ccc4[nH]3)cc2)c1[N+](=O)[O-] CHEMBL4072515 IC50 5.5 nM
CCOC(=O)CSc1nc(Sc2ccc(-c3nc4cc(C(N)=O)ccc4[nH]3)cc2)c(C#N)c(-c2ccc(Cl)cc2)n1 CHEMBL4171617 IC50 5.55 nM
CCOC(=O)CSc1nc(Oc2ccc(-c3nc4cc(C(=O)O)ccc4[nH]3)cc2)c(C#N)c(-c2ccc(F)cc2)n1 CHEMBL4159805 IC50 5.56 nM
NC(=O)c1ccc2[nH]c(-c3ccc(Oc4ccc(Cl)c(F)c4)cc3)nc2c1 CHEMBL3916197 IC50 6.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(NS(=O)(=O)c4ccc(Cl)c(Cl)c4)cc3)nc2c1 CHEMBL3909679 IC50 6.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(Oc4ccc(I)cc4)cc3)nc2c1 CHEMBL3931376 IC50 6.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(S(=O)(=O)c4ccc(Cl)cc4)cc3)nc2c1 CHEMBL193990 IC50 6.6 nM
Cc1nn(-c2ccccc2)c(Oc2ccc(-c3nc4cc(C(=O)NC5CCCCC5)ccc4[nH]3)cc2)c1[N+](=O)[O-] CHEMBL4093249 IC50 6.9 nM
CC1(COc2ccc(Cl)cc2NC(=O)Nc2cnc(C#N)cn2)COC1 CHEMBL192161 IC50 7.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(Sc4ccc(Cl)cc4)cc3)nc2c1 CHEMBL191969 IC50 7.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(C(=O)c4ccc5ccccc5c4)cc3)nc2c1 CHEMBL3909860 IC50 7.0 nM
Cc1ccc(C(O)c2ccc(-c3nc4cc(C(N)=O)ccc4[nH]3)cc2)cc1C CHEMBL3919437 IC50 7.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(C(=O)c4ccc(Cl)c(Cl)c4)cc3)nc2c1 CHEMBL3967758 IC50 7.0 nM
CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C CHEMBL535 Kd 7.1 nM
Nc1nc(C2=C3C(=Nc4ccccc43)C(=O)NCC2)c(O)[nH]1 CHEMBL332551 IC50 8.0 nM
CC(C)(O)[C@@H]1CNC[C@H]1Nc1nc(-c2cc(-c3cc[nH]n3)ccc2O)nc2ccccc12 CHEMBL1650131 IC50 8.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(C(O)c4ccc(Cl)c(Cl)c4)cc3)nc2c1 CHEMBL3968771 IC50 8.0 nM
COc1cccc(OCCCN)c1-c1cc(Nc2cnc(C#N)cn2)n[nH]1 CHEMBL3544911 IC50 8.0 nM
NC1=NC(=O)/C(=C2\CCNC(=O)c3[nH]c4ccccc4c32)N1 CHEMBL481333 IC50 8.0 nM
Oc1ccc(-c2ccn[nH]2)cc1-c1nc(N[C@H]2CCNC2)c2ccccc2n1 CHEMBL1234108 IC50 9.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(Oc4ccc(Cl)cc4O)cc3)nc2c1 CHEMBL3942698 IC50 9.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(S(=O)(=O)N4Cc5ccccc5C4)cc3)nc2c1 CHEMBL3911761 IC50 9.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(C(O)c4cnc5ccccc5c4)cc3)nc2c1 CHEMBL3897209 IC50 9.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(C(O)c4ccc(Cl)cc4)cc3)nc2c1 CHEMBL3943846 IC50 9.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(Oc4ccc(Cl)c(O)c4)cc3)nc2c1 CHEMBL175472 IC50 9.8 nM
COc1ccc(N/N=C/c2c(C)nn(-c3ccccc3)c2Oc2ccc(-c3nc4cc(C(=O)O)ccc4[nH]3)cc2)cc1 CHEMBL4165600 IC50 9.95 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)N[C@H]4O CHEMBL574737 IC50 10.0 nM
CN(C(=O)C1CCCCC1)c1ccc2c(c1)nc(NC(=O)c1ccc(C#N)cc1)n2C CHEMBL519697 pKi 10.0 nM
CNC1CC2OC(C)(C1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL1980995 pKi 10.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(Oc4ccc(F)c(Cl)c4)cc3)nc2c1 CHEMBL3953915 IC50 10.0 nM
CCc1ccc(Sc2ccc(-c3nc4cc(C(N)=O)ccc4[nH]3)cc2)cc1 CHEMBL3909532 IC50 10.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(S(=O)(=O)Nc4ccc(Cl)cc4)cc3)nc2c1 CHEMBL195846 IC50 10.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(S(=O)(=O)N[C@H]4CCc5ccccc54)cc3)nc2c1 CHEMBL3904091 IC50 10.0 nM
COCCOc1ccc2c(N[C@H]3CCNC3)nc(-c3cc(F)ccc3O)nc2c1 CHEMBL1650126 IC50 11.0 nM
COc1cc2nc(-c3cc(F)ccc3O)nc(N[C@@H]3CNC[C@H]3CO)c2cc1OC CHEMBL1650129 IC50 11.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(Oc4cccc(Cl)c4)c([N+](=O)[O-])c3)nc2c1 CHEMBL3924211 IC50 11.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(C(=O)c4ccc(Cl)c(C(F)(F)F)c4)cc3)nc2c1 CHEMBL3926180 IC50 11.0 nM
Cc1nn(-c2ccccc2)c(Oc2ccc(-c3nc4cc(C(N)=O)ccc4[nH]3)cc2)c1/C=N/NC(N)=O CHEMBL4170221 IC50 11.13 nM
Cc1nn(-c2ccccc2)c(Oc2ccc(-c3nc4cc([N+](=O)[O-])ccc4[nH]3)cc2)c1/C=N/NC(N)=S CHEMBL4177291 IC50 11.49 nM
Cc1nn(-c2ccccc2)c(Oc2ccc(-c3nc4cc([N+](=O)[O-])ccc4[nH]3)cc2)c1/C=N/Nc1ccccc1 CHEMBL4170505 IC50 11.73 nM
NC(=O)c1ccc2[nH]c(-c3ccc(Oc4cc(C(F)(F)F)ccc4F)cc3)nc2c1 CHEMBL361378 IC50 12.0 nM
Cc1ccc(Oc2ccc(-c3nc4cc(C(N)=O)ccc4[nH]3)cc2)cc1C CHEMBL362255 IC50 12.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(Oc4ccc5ccccc5c4)cc3)nc2c1 CHEMBL369254 IC50 12.0 nM
COc1cc2nc(-c3cc(F)ccc3O)nc(N[C@H]3CCNC3)c2cc1OC CHEMBL1650125 IC50 12.0 nM
CCc1ccc(Cc2ccc(-c3nc4cc(C(N)=O)ccc4[nH]3)cc2)cc1 CHEMBL3901442 IC50 12.0 nM
O=C(Nc1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12)c1ccccc1 CHEMBL1999931 pKi 12.59 nM
Cc1nn(-c2ccccc2)c(Oc2ccc(-c3nc4cc(C(=O)O)ccc4[nH]3)cc2)c1/C=N/NC(N)=S CHEMBL4173655 IC50 12.9 nM
NC(=O)c1ccc2[nH]c(-c3ccc([S+]([O-])c4ccc(Cl)cc4)cc3)nc2c1 CHEMBL364978 IC50 13.0 nM
CC(CO)NC(=N)c1c(O)nsc1Nc1ccc(Nc2ccccc2)cc1 CHEMBL253116 IC50 13.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(S(=O)(=O)Nc4ccc(C(F)(F)F)cc4)cc3)nc2c1 CHEMBL3935552 IC50 13.0 nM
COc1cccc(Sc2ccc(-c3nc4cc(C(N)=O)ccc4[nH]3)cc2)c1 CHEMBL3919738 IC50 13.0 nM
CCc1ccc(C(O)c2ccc(-c3nc4cc(C(N)=O)ccc4[nH]3)cc2)cc1 CHEMBL3922168 IC50 13.0 nM
CCc1ccc(C(=O)c2ccc(-c3nc4cc(C(N)=O)ccc4[nH]3)cc2)cc1 CHEMBL3971801 IC50 13.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(OCC4CCCN(Cc5ccc(Cl)cc5)C4)cc3)nc2c1 CHEMBL248935 IC50 14.0 nM
CC(C)(O)[C@@H]1CNC[C@H]1Nc1nc(-c2cc(-c3cn[nH]c3)ccc2O)nc2ccccc12 CHEMBL1650130 IC50 14.0 nM
COc1ccc(-c2cc3c([nH]2)C(=O)NCC/C3=C2/NC(N)=NC2=O)cc1 CHEMBL1947251 IC50 14.0 nM
COc1ccc(-c2cc3c([nH]2)C(=O)NCC/C3=C2/NC(N)=NC2=O)cc1OC CHEMBL1947252 IC50 14.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(Oc4ccc(C(F)(F)F)cc4)cc3)nc2c1 CHEMBL3942502 IC50 14.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(Oc4ccc(Br)cc4)cc3)nc2c1 CHEMBL3894750 IC50 14.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(S(=O)(=O)Nc4ccc([N+](=O)[O-])cc4)cc3)nc2c1 CHEMBL3970129 IC50 14.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(Oc4ccc5c(c4)OCO5)cc3)nc2c1 CHEMBL3894138 IC50 14.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(C(O)c4ccc(Cl)cc4Cl)cc3)nc2c1 CHEMBL3931377 IC50 14.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(OC4CCCN(Cc5ccc(Cl)cc5)C4)cc3)nc2c1 CHEMBL3928245 IC50 14.0 nM
CNC(=O)c1ccc2[nH]c(-c3ccc(Oc4c([N+](=O)[O-])c(C)nn4-c4ccccc4)cc3)nc2c1 CHEMBL4063921 IC50 14.9 nM
NC(=O)c1ccc2[nH]c(-c3ccc(Oc4ccc(Cl)cc4)cc3)nc2c1 CHEMBL179583 IC50 15.0 nM
COc1ccc(Sc2ccc(-c3nc4cc(C(N)=O)ccc4[nH]3)cc2)cc1OC CHEMBL3970700 IC50 15.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(S(=O)(=O)Nc4ccc(Br)cc4)cc3)nc2c1 CHEMBL3933192 IC50 15.0 nM
N#Cc1c(Oc2ccc(-c3nc4cc(C(=O)O)ccc4[nH]3)cc2)nc(S)nc1-c1ccccc1 CHEMBL4167715 IC50 15.35 nM
O=C1NCCc2[nH]c(-c3ccnc(C=Cc4ccccc4)c3)cc21 CHEMBL1997129 pKi 15.85 nM
O=C(NCC1CCCCC1)c1cc2c(-c3ccccc3)n[nH]c2s1 CHEMBL2005475 pKi 15.85 nM
COc1cccc(CNC(=O)c2cc3c(-c4ccccc4)n[nH]c3s2)c1 CHEMBL1987009 pKi 15.85 nM
Cc1cc(Oc2ccc(-c3nc4cc(C(N)=O)ccc4[nH]3)cc2)ccc1F CHEMBL3904466 IC50 16.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(S(=O)(=O)Nc4ccc(Cl)cc4Cl)cc3)nc2c1 CHEMBL3971843 IC50 16.0 nM
Cc1ccc(C(O)c2ccc(-c3nc4cc(C(N)=O)ccc4[nH]3)cc2)cc1 CHEMBL3968271 IC50 16.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(S(=O)(=O)NC4CCCc5ccccc54)cc3)nc2c1 CHEMBL3889698 IC50 16.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(Oc4cccc(Cl)c4)cc3)nc2c1 CHEMBL178972 IC50 17.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(Oc4ccc5c(c4)CCCC5)cc3)nc2c1 CHEMBL3923429 IC50 17.0 nM
Cc1ccc(C(=O)c2ccc(-c3nc4cc(C(N)=O)ccc4[nH]3)cc2)cc1C CHEMBL3939843 IC50 17.0 nM
Cc1nn(-c2ccccc2)c(Oc2ccc(-c3nc4cc(C(=O)NC(C)C)ccc4[nH]3)cc2)c1[N+](=O)[O-] CHEMBL4085496 IC50 17.9 nM
NC(=O)c1ccc2[nH]c(-c3ccc(S(=O)(=O)Nc4ccccc4)cc3)nc2c1 CHEMBL195320 IC50 18.0 nM
Cc1ccc(Cl)cc1Oc1ccc(-c2nc3cc(C(N)=O)ccc3[nH]2)cc1 CHEMBL3906984 IC50 18.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(S(=O)(=O)N4CCc5ccccc54)cc3)nc2c1 CHEMBL3941646 IC50 18.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(C(=O)c4ccc(Cl)cc4Cl)cc3)nc2c1 CHEMBL3940297 IC50 18.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(Oc4cccc(C(F)(F)F)c4)cc3)nc2c1 CHEMBL3964555 IC50 19.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(S(=O)(=O)NCc4cccs4)cc3)nc2c1 CHEMBL3925035 IC50 19.0 nM
CN(C(=O)C1CCCCC1)c1ccc2c(c1)nc(NC(=O)c1ccc(C#N)cc1)n2CCC(N)=O CHEMBL485556 pKi 19.95 nM
O=C(NCc1ccc(Cl)cc1)c1cc2c(-c3ccccc3)n[nH]c2s1 CHEMBL1967094 pKi 19.95 nM
NCCCn1cc(-c2cc(-c3cc4ccccc4s3)c3[nH]ncc3c2)c2nc(N)ncc21 CHEMBL592030 pKi 19.95 nM
O=C1Cc2c([nH]c3ccc([N+](=O)[O-])cc23)-c2ccccc2N1 CHEMBL50894 pKi 19.95 nM
Cc1cccc(Nc2nccc(Nc3c(NC(C)C(C)(C)C)c(=O)c3=O)n2)c1 CHEMBL1969523 pKi 19.95 nM
Nc1ncnc(Nc2cc(CNC(=O)C(F)(F)F)c(O)c(-c3ccc(Cl)cc3)c2)n1 CHEMBL2001239 pKi 19.95 nM
O=C(Nc1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12)c1cccc(F)c1 CHEMBL2003638 pKi 19.95 nM
NC1=NC(=O)/C(=C2\CCNC(=O)c3[nH]c(-c4ccccc4)cc32)N1 CHEMBL1947250 IC50 20.0 nM
CC(C)(O)[C@@H]1CNC[C@H]1Nc1nc(-c2cc(F)ccc2O)nc2ccccc12 CHEMBL1650117 IC50 21.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(Sc4ccc(Cl)cc4)nc3)nc2c1 CHEMBL3916678 IC50 21.0 nM
COc1ccc(Oc2ccc(-c3nc4cc(C(N)=O)ccc4[nH]3)cc2)cc1 CHEMBL176164 IC50 23.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(OCCC4CCN(C(=O)c5ccccc5)CC4)cc3)nc2c1 CHEMBL250360 IC50 23.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(C(O)c4ccc5c(c4)OCO5)cc3)nc2c1 CHEMBL3938370 IC50 23.0 nM
Cc1ccc(Oc2ccc(-c3nc4cc(C(N)=O)ccc4[nH]3)cc2)cc1 CHEMBL175879 IC50 24.0 nM
COc1cc2c(cc1F)C(c1ccccc1Cl)=Nc1c(n[nH]c1C)N2 CHEMBL1980391 IC50 24.0 nM
Cn1cc(-c2cnc3c(-c4csc(C(=O)N[C@@H]5CCCC[C@@H]5N)c4)cnn3c2)cn1 CHEMBL4568087 IC50 24.0 nM
N#Cc1c(Nc2ccc(-c3nc4cc(C(=O)O)ccc4[nH]3)cc2)nc(=S)[nH]c1-c1ccc([N+](=O)[O-])cc1 CHEMBL4164161 IC50 25.8 nM
Cc1nn(-c2ccccc2)c(Oc2ccc(-c3nc4cc(C(=O)O)ccc4[nH]3)cc2)c1/C=N/NC(N)=O CHEMBL4165737 IC50 25.84 nM
NC(=O)c1ccc2[nH]c(-c3ccc(Oc4cccc(C(F)(F)F)c4F)cc3)nc2c1 CHEMBL3907976 IC50 26.0 nM
Cc1ccc(Oc2ccc(-c3nc4cc(C(N)=O)ccc4[nH]3)cc2)c(Cl)c1 CHEMBL3891573 IC50 26.0 nM
Cc1ccc(Sc2ccc(-c3nc4cc(C(N)=O)ccc4[nH]3)cn2)cc1 CHEMBL3956950 IC50 26.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(Cc4ccc5c(c4)OCCO5)cc3)nc2c1 CHEMBL3935525 IC50 26.0 nM
N#Cc1c(Oc2ccc(-c3nc4cc(C(=O)O)ccc4[nH]3)cc2)nc(S)nc1-c1ccc(Cl)cc1 CHEMBL4165274 IC50 27.88 nM
Cc1nn(-c2ccccc2)c(Sc2ccc(-c3nc4cc(C(=O)O)ccc4[nH]3)cc2)c1/C=N/NC(N)=O CHEMBL4177025 IC50 27.91 nM
NCCNC(=O)c1cc(-c2scc3c2OCCO3)cnc1N CHEMBL599171 IC50 28.0 nM
COc1cc2nc(-c3ccccc3O)nc(N[C@H]3CCNC3)c2cc1OC CHEMBL1650123 IC50 28.0 nM
O=C1N=C(NCc2ccccc2)N/C1=C1/CCNC(=O)c2[nH]c(-c3ccccc3)cc21 CHEMBL1947253 IC50 28.0 nM
CCc1ccc(Oc2ccc(-c3nc4cc(C(N)=O)ccc4[nH]3)cc2)cc1 CHEMBL3951780 IC50 28.0 nM
COc1ccc(-c2nc(S)nc(Sc3ccc(-c4nc5cc(C(N)=O)ccc5[nH]4)cc3)c2C#N)cc1 CHEMBL4160772 IC50 28.0 nM
Cc1nn(-c2ccccc2)c(Oc2ccc(-c3nc4cc(C(N)=O)ccc4[nH]3)cc2)c1/C=N/Nc1ccccc1 CHEMBL4177437 IC50 28.08 nM
COc1ccc2c(N[C@H]3CCNC3)nc(-c3ccccc3O)nc2c1 CHEMBL1650119 IC50 29.0 nM
COc1c(Nc2ncc(Cl)c(N[C@H]3[C@@H](C(N)=O)[C@@H]4C=C[C@H]3C4)n2)ccc2c1CC[C@@H](N1CCOCC1)CC2 CHEMBL2064666 IC50 29.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(Oc4ccc(F)cc4)cc3)nc2c1 CHEMBL3942275 IC50 29.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(S(=O)(=O)Nc4ccc5ccccc5c4)cc3)nc2c1 CHEMBL3923712 IC50 29.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(C(O)c4ccccc4)cc3)nc2c1 CHEMBL3982891 IC50 29.0 nM
Cc1nn(-c2ccccc2)c(Oc2ccc(-c3nc4cc(C(N)=O)ccc4[nH]3)cc2)c1/C=N/Nc1ccc([N+](=O)[O-])cc1 CHEMBL4162300 IC50 29.2 nM
COCCOc1cc2nc(-c3cc(F)ccc3O)nc(N[C@H]3CCNC3)c2cc1OC CHEMBL1650127 IC50 30.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(Oc4ccc(N)cc4)cc3)nc2c1 CHEMBL3956680 IC50 30.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(OCCC4CCCCN4Cc4ccc(Cl)c(Cl)c4)cc3)nc2c1 CHEMBL251155 IC50 30.0 nM
COc1ccc(Oc2ccc(-c3nc4cc(C(N)=O)ccc4[nH]3)cc2)cc1OC CHEMBL179267 IC50 31.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(N4CCN(c5ccccn5)CC4)cc3)nc2c1 CHEMBL3889622 IC50 31.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(N4CCN(c5cccc(Cl)c5)CC4)cc3)nc2c1 CHEMBL3939390 IC50 31.0 nM
Cc1nn(-c2ccccc2)c(Oc2ccc(-c3nc4cc(C(N)=O)ccc4[nH]3)cc2)c1[N+](=O)[O-] CHEMBL4090789 IC50 31.0 nM
N#Cc1c(Oc2ccc(-c3nc4cc(C(N)=O)ccc4[nH]3)cc2)nc(S)nc1-c1ccccc1 CHEMBL4175894 IC50 31.0 nM
Cc1nn(-c2ccccc2)c(Oc2ccc(-c3nc4cc(C(N)=O)ccc4[nH]3)cc2)c1/C=N/NC(N)=S CHEMBL4160826 IC50 31.55 nM
N#CCOc1ccc(Nc2nc(Nc3cccc(S(N)(=O)=O)c3)ncc2Br)cc1 CHEMBL1987034 pKi 31.62 nM
COc1ccc(Nc2nccc(Nc3c(NC(C)C(C)(C)C)c(=O)c3=O)n2)cc1OC CHEMBL1964399 pKi 31.62 nM
CCN(CC)CCNC(=O)c1c(C)[nH]c(C=C2C(=O)Nc3ccc(F)cc32)c1C CHEMBL1990885 pKi 31.62 nM
Cc1nn(-c2ccccc2)c(Oc2ccc(-c3nc4cc([N+](=O)[O-])ccc4[nH]3)cc2)c1/C=N/Nc1ccc([N+](=O)[O-])cc1 CHEMBL4167099 IC50 31.82 nM
NC(=O)c1ccc2[nH]c(-c3ccc(OCc4ccccc4)cc3)nc2c1 CHEMBL192022 IC50 32.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(C(=O)C4CCCCC4)cc3)nc2c1 CHEMBL3944471 IC50 32.0 nM
CCOC(=O)CSc1nc(Oc2ccc(-c3nc4cc(C(N)=O)ccc4[nH]3)cc2)c(C#N)c(-c2ccc(F)cc2)n1 CHEMBL4161839 IC50 32.4 nM
Cc1nn(-c2ccc(C#N)cc2)c(Oc2ccc(-c3nc4cc(C(=O)O)ccc4[nH]3)cc2)c1[N+](=O)[O-] CHEMBL4100980 IC50 32.5 nM
NS(=O)(=O)c1ccc2[nH]c(-c3ccc(Sc4ccc(F)c(Cl)c4)cc3)nc2c1 CHEMBL3952374 IC50 33.0 nM
Cc1ccc(C(=O)c2ccc(-c3nc4cc(C(N)=O)ccc4[nH]3)cc2)cc1 CHEMBL3948826 IC50 33.0 nM
COc1ccc(C(O)c2ccc(-c3nc4cc(C(N)=O)ccc4[nH]3)cc2)cc1 CHEMBL3965842 IC50 33.0 nM
Cc1nn(-c2ccc(C#N)cc2)c(Oc2ccc(-c3nc4cc([N+](=O)[O-])ccc4[nH]3)cc2)c1[N+](=O)[O-] CHEMBL4103039 IC50 33.4 nM
COc1ccc(-c2[nH]c(=S)nc(Nc3ccc(-c4nc5cc(C(=O)O)ccc5[nH]4)cc3)c2C#N)cc1 CHEMBL4168692 IC50 33.4 nM
Cc1nn(-c2ccc(C#N)cc2)c(Oc2ccc(-c3nc4cc(C(N)=O)ccc4[nH]3)cc2)c1[N+](=O)[O-] CHEMBL4062848 IC50 33.8 nM
N#Cc1c(Oc2ccc(-c3nc4cc(C(N)=O)ccc4[nH]3)cc2)nc(S)nc1-c1ccc(Cl)cc1 CHEMBL4172486 IC50 33.8 nM
NC(=O)c1ccc2[nH]c(-c3ccc(N4CCN(c5ccc(F)cc5)CC4)cc3)nc2c1 CHEMBL3929268 IC50 34.0 nM
COc1cc(C(=O)c2ccc(-c3nc4cc(C(N)=O)ccc4[nH]3)cc2)cc(Br)c1OC CHEMBL3962849 IC50 34.0 nM
Cc1nn(-c2ccccc2)c(Sc2ccc(-c3nc4cc([N+](=O)[O-])ccc4[nH]3)cc2)c1/C=N/NC(N)=O CHEMBL4173942 IC50 34.57 nM
NC(=O)c1ccc2[nH]c(-c3ccc(O[C@H]4CC[C@@H](CO)CC4)cc3)nc2c1 CHEMBL249570 IC50 35.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(Oc4ccc(Cl)c(Cl)c4)cc3)nc2n1 CHEMBL3924947 IC50 35.0 nM
Cc1ccc(-c2nc(S)nc(Sc3ccc(-c4nc5cc(C(N)=O)ccc5[nH]4)cc3)c2C#N)cc1 CHEMBL4160383 IC50 35.9 nM
COc1ccc(N/N=C/c2c(C)nn(-c3ccccc3)c2Oc2ccc(-c3nc4cc([N+](=O)[O-])ccc4[nH]3)cc2)cc1 CHEMBL4162573 IC50 35.91 nM
NC(=O)c1ccc2[nH]c(-c3ccc(C(=O)c4ccc5c(c4)OCO5)cc3)nc2c1 CHEMBL3958455 IC50 36.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(OCC4CCCN(Cc5ccccc5)C4)cc3)nc2c1 CHEMBL250765 IC50 37.0 nM
OC[C@@H]1CNC[C@H]1Nc1nc(-c2cc(F)ccc2O)nc2ccccc12 CHEMBL1650056 IC50 37.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(S(=O)(=O)NCc4ccco4)cc3)nc2c1 CHEMBL3923965 IC50 37.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(C(=O)c4cnc5ccccc5c4)cc3)nc2c1 CHEMBL3908369 IC50 38.0 nM
CN(c1ccccc1)c1ccc(-c2nc3cc(C(N)=O)ccc3[nH]2)cc1 CHEMBL3902704 IC50 38.0 nM
Cn1cc(-c2[nH]c3cc(NC(=O)[C@H](N)C4CCCCC4)cc4c3c2C=NNC4=O)cn1 CHEMBL3990456 EC50 38.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(OCC4CCN(C(=O)c5ccccc5)CC4)cc3)nc2c1 CHEMBL250158 IC50 39.0 nM
NCCNC(=O)c1cc(-c2ccsc2)cnc1N CHEMBL610226 IC50 39.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(C(=O)c4ccc5c(c4)OCCO5)cc3)nc2c1 CHEMBL3955816 IC50 39.0 nM
CN(C)c1ccc(CNC(=O)c2cc3c(-c4ccccc4)n[nH]c3s2)cc1 CHEMBL1984367 pKi 39.81 nM
NC(=O)Cn1cc(-c2cc(-c3cc4ccccc4s3)c3[nH]ncc3c2)c2nc(N)ncc21 CHEMBL1985095 pKi 39.81 nM
NCCn1cc(-c2cc(-c3cc4ccccc4s3)c3[nH]ncc3c2)c2nc(N)ncc21 CHEMBL590109 pKi 39.81 nM
O=c1c(NCc2ccc(Cl)cc2Cl)c(Nc2ccc3[nH]ncc3c2)c1=O CHEMBL1979554 pKi 39.81 nM
Cc1[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c(C)c1C(=O)NC[C@H](O)CN1CCOCC1 CHEMBL1721885 Kd 40.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(C(O)c4cc5c(cc4Cl)OCO5)cc3)nc2c1 CHEMBL3970535 IC50 40.0 nM
Cc1ccccc1C(=O)c1ccc(-c2nc3cc(C(N)=O)ccc3[nH]2)cc1 CHEMBL3916661 IC50 40.0 nM
Cc1nn(-c2ccccc2)c(Oc2ccc(-c3nc4cc(C(=O)O)ccc4[nH]3)cc2)c1/C=N/Nc1ccc([N+](=O)[O-])cc1 CHEMBL4176212 IC50 40.22 nM
CS(=O)(=O)Nc1ccc(Oc2ccc(-c3nc4cc(C(N)=O)ccc4[nH]3)cc2)cc1 CHEMBL363339 IC50 41.0 nM
O=C(Nc1ccc(Nc2ccnc3[nH]c(=O)c4ccccc4c23)cc1)c1ccccc1 CHEMBL2380845 IC50 41.0 nM
NS(=O)(=O)c1ccc2[nH]c(-c3ccc(Oc4ccc(Cl)c(C(F)(F)F)c4)cc3)nc2c1 CHEMBL3893157 IC50 41.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(Cc4cc5c(cc4Cl)OCO5)cc3)nc2c1 CHEMBL3910004 IC50 41.0 nM
CC(C)(C)OC(=O)N1CCC(COc2ccc(-c3nc4cc(C(N)=O)ccc4[nH]3)cc2)CC1 CHEMBL3985469 IC50 41.0 nM
Cc1nn(-c2ccccc2)c(Sc2ccc(-c3nc4cc(C(N)=O)ccc4[nH]3)cc2)c1/C=N/NC(N)=O CHEMBL4175850 IC50 41.64 nM
Cc1nn(-c2ccccc2)c(Oc2ccc(-c3nc4cc([N+](=O)[O-])ccc4[nH]3)cc2)c1/C=N/NC(N)=O CHEMBL4159185 IC50 41.64 nM
NC1=NC(=O)/C(=C2\CCNC(=O)c3[nH]c(Br)cc32)N1 CHEMBL361708 IC50 42.0 nM
Cc1ccccc1CNS(=O)(=O)c1ccc(-c2nc3cc(C(N)=O)ccc3[nH]2)cc1 CHEMBL3983526 IC50 42.0 nM
Cc1ccccc1Cc1ccc(-c2nc3cc(C(N)=O)ccc3[nH]2)cc1 CHEMBL3933503 IC50 42.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(C(O)c4cccs4)cc3)nc2c1 CHEMBL3954326 IC50 42.0 nM
COC(c1ccccc1)c1ccc(-c2nc3cc(C(N)=O)ccc3[nH]2)cc1 CHEMBL3985497 IC50 42.0 nM
COc1ccc(C(=O)c2ccc(-c3nc4cc(C(N)=O)ccc4[nH]3)cc2)cc1 CHEMBL3951443 IC50 43.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(C(=O)c4ccc(Cl)cc4)cc3)nc2c1 CHEMBL3913670 IC50 43.0 nM
CC(=O)N/N=C/c1c(C)nn(-c2ccccc2)c1Oc1ccc(-c2nc3cc([N+](=O)[O-])ccc3[nH]2)cc1 CHEMBL4169439 IC50 43.82 nM
NC(=O)c1ccc2[nH]c(-c3ccc(OCCC4CCCCN4Cc4ccccc4)cc3)nc2c1 CHEMBL250555 IC50 45.0 nM
COc1ccccc1Cc1ccc(-c2nc3cc(C(N)=O)ccc3[nH]2)cc1 CHEMBL3930812 IC50 45.0 nM
COc1ccc(Oc2ccc(-c3nc4cc(C(N)=O)ccc4[nH]3)cc2Cl)cc1OC CHEMBL3981163 IC50 46.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(N4CCN(c5ccccc5)CC4)cc3)nc2c1 CHEMBL3942083 IC50 46.0 nM
NS(=O)(=O)c1ccc2[nH]c(-c3ccc(Oc4ccc5ccccc5c4)cc3)nc2c1 CHEMBL3949750 IC50 46.0 nM
N#Cc1c(Sc2ccc(-c3nc4cc(C(N)=O)ccc4[nH]3)cc2)nc(S)nc1-c1ccc(Cl)cc1 CHEMBL4170989 IC50 46.2 nM
CC(=O)N/N=C/c1c(C)nn(-c2ccccc2)c1Oc1ccc(-c2nc3cc(C(=O)O)ccc3[nH]2)cc1 CHEMBL4169171 IC50 46.29 nM
NC(=O)c1ccc(Oc2ccc(-c3nc4cc(C(N)=O)ccc4[nH]3)cc2)cc1 CHEMBL362677 IC50 47.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(C(O)c4ccc5c(c4)OCCO5)cc3)nc2c1 CHEMBL3982061 IC50 47.0 nM
Cc1nn(-c2ccccc2)c(Oc2ccc(-c3nc4cc(C(=O)O)ccc4[nH]3)cc2)c1[N+](=O)[O-] CHEMBL4083002 IC50 48.4 nM
CC(=O)N/N=C/c1c(C)nn(-c2ccccc2)c1Oc1ccc(-c2nc3cc(C(N)=O)ccc3[nH]2)cc1 CHEMBL4168756 IC50 48.72 nM
NC(=O)c1ccc2[nH]c(-c3ccc(C(=O)c4ccccc4Cl)cc3)nc2c1 CHEMBL3942931 IC50 49.0 nM
Cc1cccc(CNS(=O)(=O)c2ccc(-c3nc4cc(C(N)=O)ccc4[nH]3)cc2)c1 CHEMBL3895497 IC50 50.0 nM
CC(=O)NCC(=O)N1C2CCC1c1cc(Nc3ncc(C(F)(F)F)c(NC4CCC4)n3)ccc12 CHEMBL1983111 pKi 50.12 nM
COc1ccc(C(=O)Nc2n[nH]c3ccc(-c4cn(Cc5ccccc5)nn4)cc23)cc1OC CHEMBL1991078 pKi 50.12 nM
NC(COc1cncc(-c2ccc3c(c2)C(=Cc2ccco2)C(=O)N3)c1)Cc1c[nH]c2ccccc12 CHEMBL2001751 pKi 50.12 nM
Cc1[nH]c(C=C2C(=O)Nc3ccccc32)c(C)c1CCC(=O)O CHEMBL2007064 pKi 50.12 nM
NC(=O)c1ccc2[nH]c(-c3ccc(OCCO)cc3)nc2c1 CHEMBL251585 IC50 52.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(OCCC4CCCCN4C(=O)c4ccccc4)cc3)nc2c1 CHEMBL250359 IC50 52.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(OC4CCN(Cc5ccccc5)CC4)cc3)nc2c1 CHEMBL3934741 IC50 52.0 nM
Cc1nn(-c2ccccc2)c(Oc2ccc(-c3nc4cc([N+](=O)[O-])ccc4[nH]3)cc2)c1[N+](=O)[O-] CHEMBL4076911 IC50 52.8 nM
NC(=O)c1ccc2[nH]c(-c3ccc(OCCC4CCCCN4Cc4ccc(Cl)cc4)cc3)nc2c1 CHEMBL398529 IC50 53.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(-c4ccc(F)cc4)cc3)nc2c1 CHEMBL3897063 IC50 53.0 nM
COc1ccc(N/N=C/c2c(C)nn(-c3ccccc3)c2Oc2ccc(-c3nc4cc(C(N)=O)ccc4[nH]3)cc2)cc1 CHEMBL4166813 IC50 53.2 nM
NC(=O)c1ccc2[nH]c(-c3ccc(C(=O)c4cc5c(cc4Cl)OCO5)cc3)nc2c1 CHEMBL3895207 IC50 54.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(OC[C@H]4CC[C@@H](O)CC4)cc3)nc2c1 CHEMBL3922854 IC50 54.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(Oc4ccccc4)cc3)nc2c1 CHEMBL178971 IC50 55.0 nM
COc1ccc(CN2CCCC(COc3ccc(-c4nc5cc(C(N)=O)ccc5[nH]4)cc3)C2)cc1 CHEMBL427879 IC50 55.0 nM
NS(O)(O)c1ccc2[nH]c(-c3ccc(Oc4ccc(Cl)cc4)cc3)nc2c1 CHEMBL3918849 IC50 55.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(C4(c5ccccc5)OCCO4)cc3)nc2c1 CHEMBL3965786 IC50 55.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(S(=O)(=O)NCc4ccccc4)cc3)nc2c1 CHEMBL3964913 IC50 56.0 nM
Cc1ccc(CN2CCCC(COc3ccc(-c4nc5cc(C(N)=O)ccc5[nH]4)cc3)C2)cc1 CHEMBL250963 IC50 57.0 nM
COc1cc2c(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3F)ccnc2cc1OCCCN1CCOCC1 CHEMBL1230609 Kd 57.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(OCC4CCN(Cc5ccc(Cl)cc5)CC4)cc3)nc2c1 CHEMBL251170 IC50 60.0 nM
Oc1ccc(F)cc1-c1nc(N[C@H]2CCNC2)c2ccccc2n1 CHEMBL1650105 IC50 60.0 nM
NC(=O)c1ncc(N[C@@H]2CCCC[C@@H]2N)nc1-c1nc2ccccc2[nH]1 CHEMBL3943181 IC50 60.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(Oc4ccc(Cl)cc4)cc3Cl)nc2c1 CHEMBL3971136 IC50 60.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(Oc4cccc(O)c4)cc3)nc2c1 CHEMBL367263 IC50 61.0 nM
Cc1ccc(CN2CCCCC2CCOc2ccc(-c3nc4cc(C(N)=O)ccc4[nH]3)cc2)cc1 CHEMBL250759 IC50 61.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(OC4CCCN(Cc5ccccc5)C4)cc3)nc2c1 CHEMBL3939511 IC50 63.0 nM
CCCCn1c(NC(=O)c2ccc(C#N)cc2)nc2cc(N(C)C(=O)C3CCCCC3)ccc21 CHEMBL484390 pKi 63.1 nM
CN1CCN(C2CCC(n3cc(-c4ccc(Oc5ccccc5)cc4)c4c(N)ncnc43)CC2)CC1 CHEMBL1997617 pKi 63.1 nM
NC(=O)c1ccc2[nH]c(-c3ccc(C(=O)c4ccccc4)cc3)nc2c1 CHEMBL3896405 IC50 64.0 nM
Oc1ccc(-c2cn[nH]c2)cc1-c1nc(N[C@H]2CCNC2)c2ccccc2n1 CHEMBL1650110 IC50 65.0 nM
CC(C)(C)OC(=O)N1CCCC(Oc2ccc(-c3nc4cc(C(N)=O)ccc4[nH]3)cc2)C1 CHEMBL3975740 IC50 65.0 nM
Cc1nn(-c2ccccc2)c(Oc2ccc(-c3nc4cc(C(=O)O)ccc4[nH]3)cc2)c1/C=N/Nc1ccccc1 CHEMBL4166017 IC50 65.07 nM
NC(=O)c1ccc2[nH]c(-c3ccc(S(=O)(=O)NCc4ccc(Cl)cc4)cc3)nc2c1 CHEMBL3916397 IC50 66.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(C4(c5ccc(Cl)cc5)OCCO4)cc3)nc2c1 CHEMBL3929480 IC50 66.0 nM
COc1ccc(CN2CCC(COc3ccc(-c4nc5cc(C(N)=O)ccc5[nH]4)cc3)CC2)cc1 CHEMBL250159 IC50 67.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(Sc4ccc(OC(F)(F)F)cc4)cc3)nc2c1 CHEMBL3954343 IC50 67.0 nM
Cc1cc(Oc2ccc(-c3nc4cc(C(N)=O)ccc4[nH]3)cc2Cl)ccc1F CHEMBL3923496 IC50 68.0 nM
COc1cc(C)ccc1Oc1ccc(-c2nc3cc(C(N)=O)ccc3[nH]2)cc1Cl CHEMBL3923907 IC50 68.0 nM
COc1ccc(NS(=O)(=O)c2ccc(-c3nc4cc(C(N)=O)ccc4[nH]3)cc2)cc1 CHEMBL3892460 IC50 69.0 nM
Cc1ccc(CN2CCC(COc3ccc(-c4nc5cc(C(N)=O)ccc5[nH]4)cc3)CC2)cc1 CHEMBL398467 IC50 70.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(OCC4CCN(Cc5ccccc5)CC4)cc3)nc2c1 CHEMBL249959 IC50 70.0 nM
Oc1ccc(Cl)cc1-c1nc(N[C@H]2CCNC2)c2ccccc2n1 CHEMBL1650106 IC50 70.0 nM
COCCOc1ccc2c(N[C@H]3CCNC3)nc(-c3ccccc3O)nc2c1 CHEMBL1650121 IC50 70.0 nM
Cc1ccc(Oc2ccc(-c3nc4cc(C(N)=O)ccc4[nH]3)cc2Cl)cc1Cl CHEMBL3921179 IC50 71.0 nM
COc1cc(C(O)c2ccc(-c3nc4cc(C(N)=O)ccc4[nH]3)cc2)cc(Br)c1OC CHEMBL3985771 IC50 71.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(OC4CCC(O)C4)cc3)nc2c1 CHEMBL250992 IC50 72.0 nM
CN(C)c1cccc(Oc2ccc(-c3nc4cc(C(N)=O)ccc4[nH]3)cc2)c1 CHEMBL3982788 IC50 72.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(OCCCO)cc3)nc2c1 CHEMBL250796 IC50 73.0 nM
COc1ccc(CN2CCCCC2CCOc2ccc(-c3nc4cc(C(N)=O)ccc4[nH]3)cc2)cc1 CHEMBL250957 IC50 74.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(OCC4CCCN(Cc5ccc(Cl)c(Cl)c5)C4)cc3)nc2c1 CHEMBL399933 IC50 75.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(Oc4ccc(Cl)cc4)cc3)nc2n1 CHEMBL206609 IC50 77.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(C(=O)c4cccs4)cc3)nc2c1 CHEMBL3904920 IC50 77.0 nM
CC(=O)N1CCC(COc2ccc(-c3nc4cc(C(N)=O)ccc4[nH]3)cc2)CC1 CHEMBL400755 IC50 78.0 nM
OCCCc1ccc2c(N[C@H]3CCNC3)nc(-c3ccccc3O)nc2c1 CHEMBL1650122 IC50 78.0 nM
Cc1cc(N2CCOCC2)cc2[nH]c(-c3c(NCC(O)c4cccc(Cl)c4)cc[nH]c3=O)nc12 CHEMBL2005886 pKi 79.43 nM
Cc1n[nH]c2cnc(-c3cncc(OCC(N)Cc4cccc(C(F)(F)F)c4)c3)cc12 CHEMBL1998159 pKi 79.43 nM
O=c1c(NCc2ccc(Cl)c(Cl)c2)c(Nc2ccncc2)c1=O CHEMBL1975900 pKi 79.43 nM
Cc1cc(C)c(C=C2C(=O)Nc3ccccc32)[nH]1 CHEMBL2002702 pKi 79.43 nM
CN1CCC(NC(=O)c2cc3c(-c4ccccc4)n[nH]c3s2)CC1 CHEMBL1987007 pKi 79.43 nM
Cn1c2ccccc2c2c3c(c4c5ccccc5n(CCC#N)c4c21)CNC3=O CHEMBL302449 pKi 79.43 nM
Nc1ncc(-c2cnn(CCO)c2)c2scc(-c3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12 CHEMBL1980297 pKi 79.43 nM
CNS(=O)(=O)c1ccccc1Nc1nc(Nc2cc(OC)c(OC)c(OC)c2)ncc1Cl CHEMBL1993661 pKi 79.43 nM
NC(=O)c1ccc2[nH]c(-c3ccc(OC4CCC(O)CC4)cc3)nc2c1 CHEMBL249569 IC50 80.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(C(O)c4ccccc4Cl)cc3)nc2c1 CHEMBL3931050 IC50 80.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(Oc4ccc([N+](=O)[O-])cc4)cc3)nc2c1 CHEMBL193397 IC50 81.0 nM
OC[C@H]1C[C@H](Nc2nc(-c3cc(F)ccc3O)nc3ccccc23)CN1 CHEMBL1650115 IC50 81.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(OCCC4CCN(Cc5ccc(Cl)cc5)CC4)cc3)nc2c1 CHEMBL438868 IC50 82.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(OC4CCN(Cc5ccccc5)C4)cc3)nc2c1 CHEMBL248934 IC50 84.0 nM
CC(C)(C)OC(=O)N1CCCC(COc2ccc(-c3nc4cc(C(N)=O)ccc4[nH]3)cc2)C1 CHEMBL3901181 IC50 84.0 nM
CC(=O)N1CCC(CCOc2ccc(-c3nc4cc(C(N)=O)ccc4[nH]3)cc2)CC1 CHEMBL249566 IC50 86.0 nM
CC(C)NC(=N)c1c(O)nsc1Nc1ccc(Nc2ccc(Br)cc2)cc1 CHEMBL250230 IC50 87.0 nM
CC(C)(C)Nc1c(Nc2ccnc(Nc3ccc(-c4ccncc4)cc3)n2)c(=O)c1=O CHEMBL2205426 Ki 88.0 nM
CC(C)(C)OC(=O)N1CCCCC1CCOc1ccc(-c2nc3cc(C(N)=O)ccc3[nH]2)cc1 CHEMBL3914992 IC50 89.0 nM
Cc1ccc(CN2CCC(CCOc3ccc(-c4nc5cc(C(N)=O)ccc5[nH]4)cc3)CC2)cc1 CHEMBL249345 IC50 90.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(OCCC4CCN(Cc5ccccc5)CC4)cc3)nc2c1 CHEMBL399146 IC50 90.0 nM
NC(=O)c1ccc(-c2cc(-c3scc4c3OCCO4)cnc2N)cc1 CHEMBL602931 IC50 92.0 nM
Cc1ccc(O)c(-c2nc(N[C@H]3CCNC3)c3ccccc3n2)c1 CHEMBL1650107 IC50 92.0 nM
CC(C)(C)OC(=O)N1CCC(Oc2ccc(-c3nc4cc(C(N)=O)ccc4[nH]3)cc2)CC1 CHEMBL3963137 IC50 93.0 nM
COc1ccc(CN2CCC(CCOc3ccc(-c4nc5cc(C(N)=O)ccc5[nH]4)cc3)CC2)cc1 CHEMBL249347 IC50 95.0 nM
O=C(c1ccc(/C=C/c2n[nH]c3ccccc23)cc1)N1CCNCC1 CHEMBL1908397 Kd 95.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(OCCC4CCNCC4)cc3)nc2c1 CHEMBL3929928 IC50 97.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(C(O)C4CCCCC4)cc3)nc2c1 CHEMBL3890448 IC50 98.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(S(=O)(=O)NCc4ccc(Cl)c(Cl)c4)cc3)nc2c1 CHEMBL3919154 IC50 99.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(-c4ccccc4)cc3)nc2c1 CHEMBL193476 IC50 100.0 nM
CC(=O)N1CCCC(Oc2ccc(-c3nc4cc(C(N)=O)ccc4[nH]3)cc2)C1 CHEMBL250361 IC50 100.0 nM
NCCCOc1cc2c(c(-c3ccc(Nc4nc5ccc(Cl)cc5o4)cc3)c1)CNC2=O CHEMBL2002479 pKi 100.0 nM
Cc1cccc(Nc2nc(NC3CCCCC3N)cnc2C(N)=O)c1 CHEMBL1974328 pKi 100.0 nM
COc1cc(Nc2ncc([N+](=O)[O-])c(Nc3ccccc3C(N)=O)n2)cc(OC)c1OC CHEMBL1241473 pKi 100.0 nM
Cc1cnc(Nc2cccc(S(N)(=O)=O)c2)nc1Nc1ccc(OCC(N)=O)cc1 CHEMBL1988838 pKi 100.0 nM
NCCC(C(=O)Nc1ccc2[nH]ncc2c1)c1ccc(Cl)c(Cl)c1 CHEMBL1998121 pKi 100.0 nM
NS(=O)(=O)c1cccc(-c2n[nH]c3ccc(NC(=O)C(c4ccsc4)N4CCCC4)cc23)c1 CHEMBL3330410 IC50 100.0 nM
N#Cc1ccc(Oc2ccc(-c3nc4cc(C(N)=O)ccc4[nH]3)cc2)cc1 CHEMBL3906161 IC50 108.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(OCCCN4CCCCC4)cc3)nc2c1 CHEMBL249750 IC50 110.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(OCC4CCN(Cc5ccc(Cl)c(Cl)c5)CC4)cc3)nc2c1 CHEMBL251364 IC50 110.0 nM
Cc1ccc(CNS(=O)(=O)c2ccc(-c3nc4cc(C(N)=O)ccc4[nH]3)cc2)cc1 CHEMBL3970424 IC50 112.0 nM
CNCCN(C)C(c1ccc(Cl)cc1)c1ccc(-c2nc3cc(C(N)=O)ccc3[nH]2)cc1 CHEMBL3966673 IC50 113.0 nM
Cc1ccccc1C(O)c1ccc(-c2nc3cc(C(N)=O)ccc3[nH]2)cc1 CHEMBL3907188 IC50 114.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(N4CCN(c5cccc(Cl)c5Cl)CC4)cc3)nc2c1 CHEMBL3929382 IC50 117.0 nM
NCc1ccc(-c2cn3c(-c4cn[nH]c4)cnc3cn2)cc1 CHEMBL1170747 IC50 120.0 nM
COCCOc1cc2nc(-c3ccccc3O)nc(N[C@H]3CCNC3)c2cc1OC CHEMBL1650124 IC50 120.0 nM
COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl CHEMBL288441 Kd 120.0 nM
CN(C)CCCOc1ccc(-c2nc3cc(C(N)=O)ccc3[nH]2)cc1 CHEMBL249546 IC50 122.0 nM
O=C(Nc1cccc(Cl)c1)Nc1ncc(CCNc2ncnc3ccsc23)s1 CHEMBL482767 pKi 125.89 nM
O=C1NN=Cc2c[nH]c3cc(NC(=O)C4CC4c4ccccc4)cc1c23 CHEMBL1969502 pKi 125.89 nM
NC(=O)c1cc2c(-c3cccc(F)c3)cncc2s1 CHEMBL1971017 pKi 125.89 nM
NC(=O)c1cc2c(-c3ccccc3)cncc2s1 CHEMBL1999556 pKi 125.89 nM
O=C(O)c1ccc2[nH]c(-c3ccc(Oc4ccc(Cl)cc4)cc3)nc2c1 CHEMBL208463 IC50 133.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(S(=O)(=O)NCc4ccncc4)cc3)nc2c1 CHEMBL3960448 IC50 134.0 nM
CC(C)(C)OC(=O)N1CCC(CCOc2ccc(-c3nc4cc(C(N)=O)ccc4[nH]3)cc2)CC1 CHEMBL3978242 IC50 134.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(OCCC4CCCCN4)cc3)nc2c1 CHEMBL3898416 IC50 138.0 nM
CC(=O)N1CCCC(COc2ccc(-c3nc4cc(C(N)=O)ccc4[nH]3)cc2)C1 CHEMBL250566 IC50 140.0 nM
CC(CO)NC(=N)c1c(O)nsc1Nc1ccc(Nc2ccc(Br)cc2)cc1 CHEMBL251256 IC50 140.0 nM
CC(C)Cn1c2ccc(Nc3ncccn3)cc2c2c3c(c4c(c21)CCc1nn(C)cc1-4)C(=O)NC3 CHEMBL2010872 IC50 140.0 nM
CC(=O)N1CCC(Oc2ccc(-c3nc4cc(C(N)=O)ccc4[nH]3)cc2)CC1 CHEMBL3920003 IC50 140.0 nM
CC(CO)/N=C(\N)c1c(O)nsc1Nc1ccc(Oc2ccccc2)cc1 CHEMBL437331 IC50 142.0 nM
O=C(O)c1ccc2[nH]c(-c3ccc(S(=O)(=O)c4ccc(Cl)cc4)cc3)nc2c1 CHEMBL3921492 IC50 147.0 nM
COc1ccc(N2CCN(c3ccc(-c4nc5cc(C(N)=O)ccc5[nH]4)cc3)CC2)cc1 CHEMBL3932142 IC50 147.0 nM
CO[C@@H]1[C@H](NCCOCCOCCOCCNC(=O)CCC2=[N+]3C(=Cc4c(C)cc(C)n4[B-]3(F)F)C=C2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL4465866 Kd 147.0 nM
COc1ccc(CNS(=O)(=O)c2ccc(-c3nc4cc(C(N)=O)ccc4[nH]3)cc2)cc1 CHEMBL3950243 IC50 150.0 nM
CCOC(=O)[C@@H]1CNC[C@H]1Nc1nc(-c2cc(F)ccc2O)nc2ccccc12 CHEMBL1650055 IC50 154.0 nM
CCCNC1=NC(=O)/C(=C2\CCNC(=O)c3[nH]c(-c4ccccc4)cc32)N1 CHEMBL1944822 IC50 156.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(OCCC4CCN(Cc5ccc(Cl)c(Cl)c5)CC4)cc3)nc2c1 CHEMBL249541 IC50 157.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(OCC4CCCNC4)cc3)nc2c1 CHEMBL249776 IC50 158.0 nM
CNC(=O)c1cc2c(-c3ccccc3F)n[nH]c2s1 CHEMBL1977681 pKi 158.49 nM
O=C1Nc2ccc3ncsc3c2C1=CNc1ccc(S(=O)(=O)Nc2ccccn2)cc1 CHEMBL1973540 pKi 158.49 nM
O=C1NCCc2[nH]c(-c3ccnc(-c4cnc5ccccc5c4)c3)cc21 CHEMBL226403 pKi 158.49 nM
O=C(NCc1ccccc1)c1cccc(-c2cnc3[nH]ccc3c2)c1 CHEMBL1972142 pKi 158.49 nM
Oc1ccccc1-c1nc(N[C@H]2CCNC2)c2ccccc2n1 CHEMBL1231179 IC50 160.0 nM
NC(=O)c1ncc(N[C@@H]2CCCC[C@@H]2N)cc1-c1nc2ccccc2[nH]1 CHEMBL3415608 IC50 160.0 nM
O=C(Nc1ccc(Nc2ccnc3[nH]c(=O)c4ccccc4c23)cc1)c1ccc(F)cc1C(F)(F)F CHEMBL2380834 IC50 161.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(Oc4ccc(CCC(=O)O)cc4)cc3)nc2c1 CHEMBL3897490 IC50 163.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(C(O)c4ccncc4)cc3)nc2c1 CHEMBL3899916 IC50 164.0 nM
COc1ccccc1C(=O)c1ccc(-c2nc3cc(C(N)=O)ccc3[nH]2)cc1 CHEMBL3919402 IC50 170.0 nM
CNC1=NC(=O)/C(=C2\CCNC(=O)c3[nH]c(-c4ccccc4)cc32)N1 CHEMBL1944823 IC50 171.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(CC4CCCCC4)cc3)nc2c1 CHEMBL3953620 IC50 171.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(OCCN4CCCCC4)cc3)nc2c1 CHEMBL249350 IC50 174.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(OC4CCCNC4)cc3)nc2c1 CHEMBL400287 IC50 180.0 nM
Oc1ccccc1-c1nc(N[C@@H]2CCCNC2)c2ccccc2n1 CHEMBL1650100 IC50 180.0 nM
NC1=N/C(=C2/CCNC(=O)c3[nH]ccc32)C(=O)N1 CHEMBL255465 IC50 180.0 nM
CN(C)C(=O)[C@H]1C[C@H](Nc2nc(-c3ccccc3O)nc3ccccc23)CN1 CHEMBL1650113 IC50 181.0 nM
CC(NS(=O)(=O)c1ccc(-c2nc3cc(C(N)=O)ccc3[nH]2)cc1)c1ccccc1 CHEMBL3978421 IC50 181.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(C(=O)C4CCOCC4)cc3)nc2c1 CHEMBL3956671 IC50 182.0 nM
Cc1ccc(Oc2ccc(-c3nc4cc(C(N)=O)ccc4[nH]3)cn2)cc1 CHEMBL3961387 IC50 191.0 nM
NS(=O)(=O)c1ccc2[nH]c(-c3ccc(C(=O)c4ccc(Cl)cc4)cc3)nc2c1 CHEMBL3983794 IC50 192.0 nM
CC(=O)Nc1cccc(CNc2c(Nc3ccc4[nH]ncc4c3)c(=O)c2=O)c1 CHEMBL1988608 pKi 199.53 nM
COc1cc(C=C(C#N)c2nc3cc(C)ccc3[nH]2)c(Br)cc1O CHEMBL2000345 pKi 199.53 nM
CCOc1ccc(-c2nc3cc(C(N)=O)ccc3[nH]2)cc1 CHEMBL175780 IC50 200.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc4ccccc4c3)nc2c1 CHEMBL176326 IC50 200.0 nM
COc1ccc2nc(-c3ccccc3O)nc(N[C@H]3CCNC3)c2c1 CHEMBL1650118 IC50 200.0 nM
Oc1ccc(C(F)(F)F)cc1-c1nc(N[C@H]2CCNC2)c2ccccc2n1 CHEMBL1650109 IC50 201.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(-c4ccccc4Cl)cc3)nc2c1 CHEMBL3949385 IC50 209.0 nM
NC(=O)c1ccc(-c2cc(-c3cccc4c3OCO4)cnc2N)cc1 CHEMBL590335 IC50 210.0 nM
C[C@]12O[C@H](C[C@]1(O)CO)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)CNC4=O CHEMBL603469 Kd 210.0 nM
N=C(NCCO)c1c(O)nsc1Nc1ccc(Nc2ccc(Br)cc2)cc1 CHEMBL398561 IC50 220.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(OCC4CCNCC4)cc3)nc2c1 CHEMBL249777 IC50 231.0 nM
CN1CCC(Oc2ccc(-c3nc4cc(C(N)=O)ccc4[nH]3)cc2)CC1 CHEMBL442282 IC50 233.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(C(=O)c4ccncc4)cc3)nc2c1 CHEMBL3896690 IC50 240.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(-c4ccc(Cl)cc4)cc3)nc2c1 CHEMBL195599 IC50 250.0 nM
Oc1ccccc1-c1nc(NC2CCCCNC2)c2ccccc2n1 CHEMBL1650103 IC50 250.0 nM
NS(=O)(=O)c1cccc(Nc2ncc3ccn(-c4ccccc4)c3n2)c1 CHEMBL1988163 pKi 251.19 nM
CNC(=O)COc1ccc(Nc2nc(Nc3ccc(C)c(S(N)(=O)=O)c3)ncc2F)cc1 CHEMBL1978099 pKi 251.19 nM
Nc1ncnc2c1N=C(c1ccc(NC(=O)Nc3cc(C(F)(F)F)ccc3F)cc1)CCN2 CHEMBL411903 pKi 251.19 nM
CC(C)(C)OC(=O)n1ncc2cc(Nc3c(NCc4ccc(Cl)cc4Cl)c(=O)c3=O)ccc21 CHEMBL2005548 pKi 251.19 nM
Nc1ncnc2c1N=C(c1ccc(NC(=O)Nc3cccc(C(F)(F)F)c3)cc1)CCN2 CHEMBL260092 pKi 251.19 nM
O=C(O)c1ccccc1Nc1ccnc(Nc2ccc3[nH]ncc3c2)n1 CHEMBL396523 pKi 251.19 nM
CNS(=O)(=O)c1ccccc1Nc1nc(Nc2cc(N3CCN(C(C)=O)CC3)ccc2OC)ncc1Br CHEMBL1971029 pKi 251.19 nM
NC(=O)c1ccc2[nH]c(-c3ccc(C(c4ccc(Cl)cc4)N4CCNCC4)cc3)nc2c1 CHEMBL3961648 IC50 264.0 nM
COc1ccc(-c2cnc(N)c(-c3ccc(C(N)=O)cc3)c2)cc1OC CHEMBL588536 IC50 270.0 nM
O=C(O)c1ccc2[nH]c(-c3ccc(-c4ccc(Cl)cc4)cc3)nc2c1 CHEMBL3956375 IC50 270.0 nM
COc1ccccc1C(O)c1ccc(-c2nc3cc(C(N)=O)ccc3[nH]2)cc1 CHEMBL3947799 IC50 272.0 nM
COc1ccc(Oc2ccc(-c3nc4cc(C(=O)O)ccc4[nH]3)cc2)cc1 CHEMBL3961695 IC50 276.0 nM
CCOC(=O)CCNC1=NC(=O)/C(=C2\CCNC(=O)c3[nH]c(-c4ccccc4)cc32)N1 CHEMBL1944821 IC50 277.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(-c4ccccn4)cc3)nc2c1 CHEMBL3924197 IC50 277.0 nM
COCCOc1ccc2nc(-c3ccccc3O)nc(N[C@H]3CCNC3)c2c1 CHEMBL1650120 IC50 280.0 nM
CNC(=O)c1c(F)cccc1Nc1nc(Nc2cc3c(cc2OC)CCN3C(=O)CN(C)C)nc2[nH]ccc12 CHEMBL464552 Kd 280.0 nM
NS(=O)(=O)c1ccc2[nH]c(-c3ccc(Oc4ccccc4)cc3)nc2c1 CHEMBL176015 IC50 289.0 nM
CN(Cc1ccccc1)S(=O)(=O)c1ccc(-c2nc3cc(C(N)=O)ccc3[nH]2)cc1 CHEMBL3954095 IC50 290.0 nM
CC(=O)N1CCCCC1CCOc1ccc(-c2nc3cc(C(N)=O)ccc3[nH]2)cc1 CHEMBL400980 IC50 292.0 nM
N=C(NCC1CCCCC1)c1c(O)nsc1Nc1ccc(Nc2ccc(Br)cc2)cc1 CHEMBL399237 IC50 300.0 nM
N=C(NCCCCO)c1c(O)nsc1Nc1ccc(Nc2ccc(Br)cc2)cc1 CHEMBL251284 IC50 310.0 nM
COc1cc(-c2cnc(N)c(-c3ccc(C(N)=O)cc3)c2)ccc1O CHEMBL600441 IC50 310.0 nM
O=C(O)c1ccccc1Nc1ccnc(Nc2ccc3cn[nH]c3c2)n1 CHEMBL244378 pKi 316.23 nM
Nc1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3I)cc12 CHEMBL1975128 pKi 316.23 nM
O=c1c(NCc2ccc(Cl)cc2)c(Nc2ccncc2)c1=O CHEMBL1980489 pKi 316.23 nM
CC(C)(C)c1ccc2nc(-c3n[nH]c4ccccc34)[nH]c2c1 CHEMBL1970104 pKi 316.23 nM
COc1cc(-c2ccc3c(c2)Nc2ccc(C(=O)NCCNC(C)=O)cc2NC3=O)ccc1O CHEMBL1975500 pKi 316.23 nM
CNC(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCOCC3)cc2OC)ncc1Cl CHEMBL458997 pKi 316.23 nM
COc1ccc(-c2ccc(NC(=O)Nc3cc(F)cc(F)c3)cc2)c2c(N)noc12 CHEMBL1969190 pKi 316.23 nM
O=C1NCc2c1cccc2-c1ccc(Nc2nc3ccccc3[nH]2)cc1 CHEMBL1979057 pKi 316.23 nM
Cc1n[nH]c2sc(C(=O)NCCc3ccc(Cl)cc3)cc12 CHEMBL1998414 pKi 316.23 nM
Clc1cc(NC2CCCCC2)nc(-c2c[nH]c3ncccc23)n1 CHEMBL1997846 pKi 316.23 nM
O=C(O)c1ccc2[nH]c(-c3ccc([S+]([O-])c4ccc(Cl)cc4)cc3)nc2c1 CHEMBL3980237 IC50 348.0 nM
NC(=O)c1ccc(-c2cc(-c3cccs3)cnc2N)cc1 CHEMBL591283 IC50 350.0 nM
O=C(O)c1ccc2[nH]c(-c3ccc(Oc4ccc(F)cc4)cc3)nc2c1 CHEMBL3904289 IC50 351.0 nM
CCN1CCN(Cc2ccc(NC(=O)Nc3ccc(Oc4cc(NC)ncn4)cc3)cc2C(F)(F)F)CC1 CHEMBL574738 Kd 360.0 nM
Cc1sc(C(=O)N[C@@H]2[C@H](N)CCCC2(F)F)cc1-c1cnn2cc(Cl)cnc12 CHEMBL4552628 IC50 390.0 nM
CC(=O)N1CCN(C2CCC(n3nc(-c4ccc(NC(=O)c5cc6ccccc6n5C)cc4)c4c(N)ncnc43)CC2)CC1 CHEMBL1972584 pKi 398.11 nM
NC(=O)c1cc2c(-c3ccc(Br)c(F)c3F)cncc2s1 CHEMBL1999918 pKi 398.11 nM
NC(=O)c1cccc(-c2cnc3[nH]cc(-c4ccccc4)c3c2)c1 CHEMBL1982957 pKi 398.11 nM
CC(=NNC(=N)N)c1cc(NC(=O)c2cccc(C(=O)Nc3cc(C(C)=NNC(=N)N)cc(C(C)=NNC(=N)N)c3)c2)cc(C(C)=NNC(=N)N)c1 CHEMBL2000685 pKi 398.11 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(CN)Cc4ccccc4)c3)cc12 CHEMBL2000271 pKi 398.11 nM
COCc1nnn(-c2nonc2N)c1C(=O)NN=C(C)c1ccc(O)cc1O CHEMBL1991180 pKi 398.11 nM
CCc1c(-c2ccc(C(C)(C)O)cc2)[nH]c2nccnc12 CHEMBL1976420 pKi 398.11 nM
OC1CCC(Nc2cc(Cl)nc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1991674 pKi 398.11 nM
CS(=O)(=O)c1ccc(-c2cncc3sc(C(N)=O)cc23)cc1 CHEMBL1972362 pKi 398.11 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4ccc(Cl)c(Cl)c4)c3)cc12 CHEMBL1991063 pKi 398.11 nM
COc1cccc(C(CN)NC(=O)c2ccc(-c3ccncc3)cc2)c1 CHEMBL1976240 pKi 398.11 nM
NC(=O)c1cc2c(-c3ccc(F)cc3F)cncc2s1 CHEMBL1975787 pKi 398.11 nM
NC(COc1cncc(-c2cc3ccncc3s2)c1)Cc1c[nH]c2ccccc12 CHEMBL1966524 pKi 398.11 nM
O=C(O)c1ccccc1Nc1ccnc(Nc2cccc(O)c2)n1 CHEMBL243088 pKi 398.11 nM
NC(=O)c1ccc2[nH]c(-c3ccc(O[C@H]4CC[C@H](CO)CC4)cc3)nc2c1 CHEMBL429480 IC50 400.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(OC[C@H]4CC[C@H](O)CC4)cc3)nc2c1 CHEMBL3964628 IC50 400.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(S(=O)(=O)Nc4ccc(N5CCOCC5)cc4)cc3)nc2c1 CHEMBL3973311 IC50 409.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(C(=O)Nc4ccccc4)cc3)nc2c1 CHEMBL193394 IC50 410.0 nM
NC(=O)CCNC(=O)c1cc(-c2ccsc2)cnc1N CHEMBL599581 IC50 410.0 nM
CCc1cccc(CC)c1NC(=O)Nc1ccc2[nH]nc(-c3cccc(S(N)(=O)=O)c3)c2c1 CHEMBL3330260 IC50 410.0 nM
CC(C)NC(=N)c1c(O)nsc1Nc1ccc(Nc2ccccc2)cc1 CHEMBL253115 IC50 420.0 nM
COCCOc1cccc(-c2cnc(N)c(-c3ccc(C(N)=O)cc3)c2)c1 CHEMBL592784 IC50 420.0 nM
CCc1ccccc1C(C(=O)Nc1ccc2[nH]nc(-c3cccc(S(N)(=O)=O)c3)c2c1)N(C)C CHEMBL3330409 IC50 420.0 nM
Cn1cc(-c2cnc3c(-c4csc(C(=O)NCC(F)(F)F)c4)cnn3c2)cn1 CHEMBL4550702 IC50 420.0 nM
O=C(O)c1ccc2[nH]c(-c3ccc(Oc4ccc(Cl)cc4)cc3Cl)nc2c1 CHEMBL3960549 IC50 445.0 nM
O=C(NCC(F)(F)F)c1cc(-c2cnn3cc(-c4ccc(OCCN5CCCCC5)cc4)cnc23)cs1 CHEMBL4569508 IC50 450.0 nM
N=C(NCc1cccc2ccccc12)c1c(O)nsc1Nc1ccc(Nc2ccc(Br)cc2)cc1 CHEMBL249251 IC50 460.0 nM
CC(C)(O)[C@H]1C[C@H](Nc2nc(-c3cc(F)ccc3O)nc3ccccc23)CN1 CHEMBL1650114 IC50 460.0 nM
N=C(NCC(O)CO)c1c(O)nsc1Nc1ccc(Nc2ccc(Br)cc2)cc1 CHEMBL400772 IC50 470.0 nM
O=C(O)c1ccc2[nH]c(-c3ccc(Oc4ccc([N+](=O)[O-])cc4)cc3)nc2c1 CHEMBL3965716 IC50 478.0 nM
c1cc(-c2cnc3ncc(-c4cn[nH]c4)cn23)n[nH]1 CHEMBL1171534 IC50 480.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc4oc5ccccc5c4c3)nc2c1 CHEMBL195648 IC50 500.0 nM
CN(c1nc(-c2ccccc2O)nc2ccccc12)[C@H]1CCNC1 CHEMBL1650102 IC50 500.0 nM
COc1cc(-c2ccc3c(c2)Nc2ccc(C(=O)NCc4cccc(F)c4)cc2NC3=O)ccc1O CHEMBL2000832 pKi 501.19 nM
CCN(CC)CCNC(=O)C=Cc1cnc(N)c2c(-c3ccc(NC(=O)Nc4cccc(C)c4)cc3)csc12 CHEMBL2004716 pKi 501.19 nM
O=C(Nc1cnccn1)Nc1ccnc2ccccc12 CHEMBL1981720 pKi 501.19 nM
NC(=O)c1cc2c(-c3ccc(F)cc3)cncc2s1 CHEMBL1974310 pKi 501.19 nM
Oc1c2ccccc2c2c3c(cccc13)N=N2 CHEMBL1725279 pKi 501.19 nM
CN(C)c1cccc2c(S(=O)(=O)N(CCN)c3cncc(-c4ccc5cnccc5c4)c3)cccc12 CHEMBL1967544 pKi 501.19 nM
Cn1cc(-c2cnc(N)c3c(-c4ccc(NC(=O)Nc5cccc(F)c5)cc4)csc23)cn1 CHEMBL1970317 pKi 501.19 nM
CC(Nc1c(Nc2ccncc2)c(=O)c1=O)C(C)(C)C CHEMBL1986186 pKi 501.19 nM
NCC(NC(=O)c1ccc(-c2ccncc2)cc1)c1ccccc1 CHEMBL1990254 pKi 501.19 nM
COc1cccc(C(C)NC(=O)N2CC=C(c3c[nH]c4ncccc34)CC2)c1 CHEMBL1965845 pKi 501.19 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4c[nH]c5ccccc45)c3)cc12 CHEMBL1970903 pKi 501.19 nM
O=C(O)c1cc2c(-c3ccccc3)cncc2s1 CHEMBL1996390 pKi 501.19 nM
CC(C)(C(N)=O)n1cc(-c2cnc(N)c3c(-c4ccc(NC(=O)Nc5cccc(F)c5)cc4)csc23)cn1 CHEMBL1967720 pKi 501.19 nM
Oc1ccccc1-c1nc(NC2CCCNCC2)c2ccccc2n1 CHEMBL1650104 IC50 510.0 nM
CC(C)c1n[nH]c2c(NCc3ccc(-c4ccccn4)cc3)nc(SCCN)nc12 CHEMBL4540226 IC50 525.0 nM
NC(=O)c1ccc2[nH]c(-c3cccc(Oc4ccc(Cl)c(Cl)c4)c3)nc2c1 CHEMBL175676 IC50 530.0 nM
CCc1cccc(CC)c1N1CCn2cc(-c3nc(Nc4ccc(N5CCC(C(=O)N6CC7(CN(C)C7)C6)CC5)cc4OC)nc4[nH]ccc34)cc2C1=O CHEMBL5085753 IC50 545.0 nM
Nc1ncc(-c2ccc(C(=O)NCC3CCNC3)cc2)nc1Oc1ccc2cc[nH]c2c1 CHEMBL573177 IC50 580.0 nM
COc1ccc(CNC2=NC(=O)/C(=C3\CCNC(=O)c4[nH]c(-c5ccccc5)cc43)N2)cc1 CHEMBL1947254 IC50 588.0 nM
COc1cccc(-c2cnc(N)c(-c3ccc(C(N)=O)cc3)c2)c1 CHEMBL590809 IC50 600.0 nM
OCCCc1ccc2nc(-c3ccccc3O)nc(N[C@H]3CCNC3)c2c1 CHEMBL1650093 IC50 600.0 nM
CNC(=O)c1ccc2[nH]c(-c3ccc(Oc4ccc(OC)cc4)cc3)nc2c1 CHEMBL3948906 IC50 601.0 nM
CNC(=O)c1ccc2[nH]c(-c3ccc(Oc4ccc(Cl)cc4)cc3)nc2c1 CHEMBL3982809 IC50 608.0 nM
Nc1ncc(-c2ccc(C(=O)N[C@@H]3CCNC3)cc2)nc1Oc1ccc2cc[nH]c2c1 CHEMBL572910 IC50 610.0 nM
NC(=O)c1ccc(-c2cc(-c3ccsc3)cnc2N)cc1 CHEMBL590637 IC50 610.0 nM
c1ccc(Cn2cc(-c3ccc4[nH]ncc4c3)nn2)cc1 CHEMBL1682345 pKi 630.96 nM
CCn1c(C)c(-c2ccnc(Nc3cccc(OC)c3)n2)sc1=O CHEMBL1986263 pKi 630.96 nM
O=C(O)c1cc2c(-c3cccc(F)c3)cncc2s1 CHEMBL1974457 pKi 630.96 nM
CC(=O)c1cccc(-c2cnc3[nH]ccc3c2)c1 CHEMBL2000568 pKi 630.96 nM
Cc1ccc(NC(=O)Nc2ccc(-c3csc4ncnc(N)c34)cc2)cc1C CHEMBL2000335 pKi 630.96 nM
Nc1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12 CHEMBL1682346 pKi 630.96 nM
COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCN1CCOCC1 CHEMBL939 pKi 630.96 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4cccc(Cl)c4)c3)cc12 CHEMBL1974870 pKi 630.96 nM
Cc1cccc(NC(=O)Nc2ccc(-c3noc4ncnc(N)c34)cc2)c1 CHEMBL211378 pKi 630.96 nM
Cn1cc(C=C2C(=O)Nc3cccnc32)c2ccccc21 CHEMBL1516890 pKi 630.96 nM
O=c1c(NCc2cccc(C(F)(F)F)c2)c(Nc2ccncc2)c1=O CHEMBL1979252 pKi 630.96 nM
O=C1NCCc2[nH]c(-c3ccnc(-c4ccccc4F)c3)cc21 CHEMBL226471 pKi 630.96 nM
O=C1Cc2c([nH]c3ccc(Br)cc23)-c2ccccc2N1 CHEMBL296586 pKi 630.96 nM
NC(=O)c1ccc2[nH]c(-c3ccc(Oc4cccnc4)cc3)nc2c1 CHEMBL3932401 IC50 633.0 nM
O=C(O)c1ccc2[nH]c(-c3ccc(Oc4ccccc4)cc3)nc2c1 CHEMBL367390 IC50 640.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(N4CCN(c5ccc([N+](=O)[O-])cc5)CC4)cc3)nc2c1 CHEMBL3961938 IC50 643.0 nM
CN(c1ccc(Cl)cc1)S(=O)(=O)c1ccc(-c2nc3cc(C(N)=O)ccc3[nH]2)cc1 CHEMBL3961522 IC50 652.0 nM
CN1CCC(Oc2ccc(-c3nc4cc(C(N)=O)ccc4[nH]3)cc2)C1 CHEMBL400936 IC50 659.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(C(=O)Nc4ccc(Cl)cc4)cc3)nc2c1 CHEMBL195598 IC50 679.0 nM
NC(=O)c1ccc(-c2cc(-c3cncs3)cnc2N)cc1 CHEMBL591518 IC50 680.0 nM
CN(C)CCNC(=O)c1cc(-c2scc3c2OCCO3)cnc1N CHEMBL598973 IC50 700.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(OC4CCNCC4)cc3)nc2c1 CHEMBL251368 IC50 710.0 nM
NC(=O)c1ccc2[nH]c(-c3ccc(Oc4cccc(C(=O)O)c4)cc3)nc2c1 CHEMBL381436 IC50 715.0 nM
COc1ccc2c(c1)C(=Cc1c[nH]cn1)C(=O)N2 CHEMBL2002649 pKi 794.33 nM
CN(c1ncccc1CNc1nc(Nc2ccc3c(c2)CC(=O)N3)ncc1C(F)(F)F)S(C)(=O)=O CHEMBL1084546 pKi 794.33 nM
CCC(N)(C#Cc1cnc(N)c2c(-c3ccc(NC(=O)Nc4cccc(C)c4)cc3)csc12)CC CHEMBL1983025 pKi 794.33 nM
Cc1ccc(CNc2c(Nc3ccncc3)c(=O)c2=O)cc1 CHEMBL1994864 pKi 794.33 nM
CNC(=O)N1CCN(CCCOc2ccc3c(c2)-c2[nH]nc(-c4ccc(C#N)nc4)c2C3)CC1 CHEMBL2001998 pKi 794.33 nM
CCN1CCN(c2ccc(Nc3nccc(-c4c(-c5cccc(C(=O)Nc6ccccc6F)c5)nc5ccccn45)n3)cc2)CC1 CHEMBL1981725 pKi 794.33 nM
COc1cc(-c2nn(C3CCC(N4CCN(C(C)=O)CC4)CC3)c3ncnc(N)c23)ccc1NC(=O)c1cc2ccccc2n1C CHEMBL1970879 pKi 794.33 nM
C#Cc1cc2c(cc1OC)-c1[nH]nc(-c3ccc(C#N)nc3)c1C2 CHEMBL1972250 pKi 794.33 nM
CC(=NNC(=N)N)c1cc(NC(=O)NCCCCCCNC(=O)Nc2cc(C(C)=NNC(=N)N)cc(C(C)=NNC(=N)N)c2)cc(C(C)=NNC(=N)N)c1 CHEMBL1991728 pKi 794.33 nM
O=c1c(NCc2ccccc2F)c(Nc2ccncc2)c1=O CHEMBL1982361 pKi 794.33 nM
CC(C)(C)NC(=O)c1ccc2nc3[nH]c4ccccc4c3nc2c1 CHEMBL1969264 pKi 794.33 nM
Nc1ncc(-c2ccc(C(=O)NC3CCNCC3)cc2)nc1Oc1ccc2cc[nH]c2c1 CHEMBL566083 IC50 800.0 nM
CCN(CC)C(=O)c1cccc(Oc2ccc(-c3nc4cc(C(N)=O)ccc4[nH]3)cc2)c1 CHEMBL195678 IC50 820.0 nM
CCc1cc(Nc2nc(NCc3ccc(Cl)cc3OC)nc3cccc(OC)c23)n[nH]1 CHEMBL4877302 IC50 820.0 nM
NC(=O)c1ccc(-c2cc(-c3ccc4c(c3)OCCO4)cnc2N)cc1 CHEMBL608262 IC50 830.0 nM
CN(C)CCCOc1cccc(-c2nc3cc(C(N)=O)ccc3[nH]2)c1 CHEMBL3910547 IC50 836.0 nM
CCOc1cc2ncc(C#N)c(Nc3ccc(OCc4ccccn4)c(Cl)c3)c2cc1NC(=O)/C=C/CN(C)C CHEMBL180022 Kd 850.0 nM
CN(C)[C@@H]1CCN(c2nc(-c3cc(F)ccc3O)nc3ccccc23)C1 CHEMBL1650097 IC50 860.0 nM
Nc1ncc(-c2ccc(C(=O)NCC3CCCNC3)cc2)nc1Oc1ccc2cc[nH]c2c1 CHEMBL567174 IC50 890.0 nM
CN(C(=O)c1ccc(-c2nc3cc(C(N)=O)ccc3[nH]2)cc1)c1ccc(Cl)cc1 CHEMBL3979896 IC50 896.0 nM
N=C(NCC(O)CO)c1c(O)nsc1Nc1ccc(Nc2ccccc2)cc1 CHEMBL401105 IC50 900.0 nM
CN1CC[C@H](Nc2nc(-c3ccccc3O)nc3ccccc23)C1 CHEMBL1650101 IC50 920.0 nM
NC(=O)c1ccc2[nH]c(-c3cccc(Oc4ccccc4)c3)nc2c1 CHEMBL176235 IC50 930.0 nM
Nc1ncc(-c2ccc(C(=O)NCC3CCCN3)cc2)nc1Oc1ccc2cc[nH]c2c1 CHEMBL575565 IC50 960.0 nM
Cc1nc2c(F)cc(-c3nc(Nc4ccc5c(n4)CCN(CCN(C)C)C5)ncc3F)cc2n1C(C)C CHEMBL4448494 IC50 978.0 nM
NC(=O)c1ccc(-c2cc(-c3nccs3)cnc2N)cc1 CHEMBL591284 IC50 990.0 nM
N=C(NCCO)c1c(O)nsc1Nc1ccc(Nc2ccccc2)cc1 CHEMBL253324 IC50 1000.0 nM
Cc1ccc(CNc2c(Nc3ccncc3)c(=O)c2=O)cc1C CHEMBL1983449 pKi 1000.0 nM
Cc1c(-c2cccc(OCc3ccccc3)c2)c2c(N)ncnc2n1C1CC(CN2CCCC2)C1 CHEMBL1968791 pKi 1000.0 nM
Cc1cccc(Cl)c1-c1cccc2c(CCCOc3cccc4ccccc34)c(C(=O)NCCOCCOCCN)[nH]c12 CHEMBL2002682 pKi 1000.0 nM
O=C(Cc1ccccc1)Nc1cccc(-c2nc3sccn3c2-c2ccnc(Nc3cccc(N4CCCC4=O)c3)n2)c1 CHEMBL1991429 pKi 1000.0 nM
Cc1n[nH]c2ccc(-c3cncc(OCC(N)Cc4cccc(OC(F)(F)F)c4)c3)cc12 CHEMBL1965836 pKi 1000.0 nM
CSc1cnc2c(ccc3cnccc32)c1O CHEMBL2006933 pKi 1000.0 nM
CCCC(=O)Nc1cccc(-c2nc(Nc3ccc4[nH]ncc4c3)c3cc(OCCN4CCCC4)ccc3n2)c1 CHEMBL1968705 pKi 1000.0 nM
Cc1cncc2cccc(S(=O)(=O)N3CCCNCC3C)c12 CHEMBL1082440 pKi 1000.0 nM
O=C(Nc1cccc(-c2nc3sccn3c2-c2ccnc(Nc3cccc(N4CCCC4=O)c3)n2)c1)c1c(F)cccc1F CHEMBL2006715 pKi 1000.0 nM
CCS(=O)(=O)c1ccc(-c2cncc3sc(C(N)=O)cc23)cc1 CHEMBL2000104 pKi 1000.0 nM
CC1=NN(c2ccc(Cl)c(Cl)c2)C(=O)C1=Cc1c(C)c(C#N)c2nc3ccccc3n2c1O CHEMBL1997349 pKi 1000.0 nM
CC(=O)N(c1ccncc1)c1c(NC(C)C(C)(C)C)c(=O)c1=O CHEMBL2005899 pKi 1000.0 nM
COc1cc2ncn(-c3cc(OCc4ccccc4C(F)(F)F)c(C(=O)O)s3)c2cc1OC CHEMBL474432 pKi 1000.0 nM
O=C(Nc1cnccn1)Nc1ccnc2cc(C(F)(F)F)ccc12 CHEMBL2003817 pKi 1000.0 nM
Nc1ncc(-c2ccoc2)c2scc(-c3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12 CHEMBL1966514 pKi 1000.0 nM
CN1C(=O)[C@@H](N2CCc3cn(Cc4ccccc4)nc3C2=O)COc2ccccc21 CHEMBL4088216 pIC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3c(nn(Cc4ccccc4)c3Br)C2=O)COc2ccccc21 CHEMBL4549667 pIC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3cn(CC4CCS(=O)(=O)CC4)nc3C2=O)COc2ccccc21 CHEMBL4097778 pIC50 1000.0 nM