CCCCCCSc1nsnc1C1=CCCN(C)C1 CHEMBL131819 IC50 0.001 nM
CCCCCSc1nsnc1C1=CCCN(C)C1 CHEMBL130715 IC50 0.002 nM
C[N+]1(C)[C@@H]2CC[C@H]1C[C@@H](CC(C#N)(c1ccccc1)c1ccccc1)C2 CHEMBL2103803 pA2 0.003981 nM
CCCCCOc1nsnc1C1=CCCN(C)C1 CHEMBL327754 IC50 0.004 nM
CCCCCCCCCCCCCC(=O)NCC(=O)N[C@@H](CO)C(=O)OCc1ccccc1 CHEMBL115078 Log Ki 0.007943 nM
CCCCCCOc1nsnc1C1=CCCN(C)C1 CHEMBL21536 IC50 0.008 nM
CCCCCCCCCCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)CCCCCCCCCCCCC)C(=O)OCc1ccccc1 CHEMBL112297 Log Ki 0.01288 nM
C[N+]1(C)[C@@H]2C[C@@H](OC(=O)C(O)(c3cccs3)c3cccs3)C[C@H]1[C@@H]1O[C@@H]12 CHEMBL3545181 Ki 0.013 nM
CN1[C@@H]2CC[C@H]1C[C@@H](CC(C#N)(c1ccccc1)c1ccccc1)C2 CHEMBL3084650 pA2 0.01585 nM
Cc1scc2c1N(C(=O)CN1CCN(CCCCCCCCCCNC(=O)Cc3ccc4c(c3)C(C)(C)C3=C5C=C6C7=[N+](CCC6OC5CCN34)c3ccc(S(=O)(=O)[O-])cc3C7(C)C)CC1)c1ccccc1NC2=O CHEMBL4634333 pKi 0.03162 nM
O=C(OC1CN2CCC1CC2)C(O)(c1ccccc1)c1ccccc1 CHEMBL12980 Ki 0.051 nM
O=C(O[C@H]1C[N+]2(CCc3ccccc3)CCC1CC2)C(O)(c1cccs1)c1cccs1 CHEMBL564057 Ki 0.08 nM
O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C(O)(c1cccs1)c1cccs1 CHEMBL551466 Ki 0.08 nM
CN1CC2CC(OC(=O)C(C)(c3ccccc3)c3ccccc3)CC1C2 CHEMBL287868 Ki 0.088 nM
O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)[C@](O)(c1cccs1)C1CCCC1 CHEMBL556635 Ki 0.09 nM
C[N+]1(C)[C@@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@H]1[C@@H]1O[C@@H]12 CHEMBL376897 pKi 0.0955 nM
CN1CCC=C(c2nsnc2OCCOCCOCCOCCOc2nsnc2C2=CCCN(C)C2)C1 CHEMBL335542 Log Ki 0.1 nM
C[N+]12CCC(CC1)[C@@H](OC(=O)Nc1ccc(F)cc1-c1cccc(Cl)c1)C2 CHEMBL4647437 Ki 0.11 nM
CC(C)(CCC(C(N)=O)(c1ccccc1)c1ccccc1)N1CC(Oc2cccc(O)c2)C1 CHEMBL1910856 Ki 0.115 nM
C[N+]1(C)CCC[C@H]1[C@H]1CS[C@@](c2ccccc2)(C2CCCCC2)O1 CHEMBL219786 Log Ki 0.1175 nM
C=CCCCC[N@+]1(C)C2CCC1C[C@H](CC(C#N)(c1ccccc1)c1ccccc1)C2 CHEMBL2023764 Ki 0.12 nM
C[N+]12CCC(CC1)[C@@H](OC(=O)Nc1ccc(F)cc1-c1ccc(F)c(Cl)c1)C2 CHEMBL4633816 Ki 0.12 nM
CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H]2CCC[N+](C)(Cc3cccc(O)c3)C2)cc1 CHEMBL540359 pA2 0.1259 nM
C[N+]1(C)CCC(OC(=O)C(O)(c2ccccc2)C2CCCC2)C1 CHEMBL1201027 pIC50 0.1259 nM
CN1[C@@H]2CC[C@H]1C[C@@H](OC(c1ccccc1)c1ccccc1)C2 CHEMBL1201203 Ki 0.131 nM
N#Cc1ccc(N2C3CCC2CN(C(=O)CCS(=O)(=O)c2cccc4ncsc24)C3)nc1 CHEMBL4790083 Ki 0.14 nM
OC(c1ccccc1)(c1ccccc1)C12CC[N+](CCOCc3ccccc3)(CC1)CC2 CHEMBL523299 Ki 0.16 nM
O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)[C@@](O)(c1ccccc1)c1cccs1 CHEMBL556222 IC50 0.16 nM
O=c1ccc2c([C@@H](O)CNCCc3ccc(CCN4CCC(Cn5cnc([C@](O)(c6ccccc6)C6CCCCC6)n5)CC4)cc3)ccc(O)c2[nH]1 CHEMBL3629360 Ki 0.16 nM
CCCCCNC(=O)/N=C(\N)NCCCc1sc(N)nc1C CHEMBL4860528 Kd 0.17 nM
CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1 CHEMBL5207281 Kd 0.17 nM
N/C(=N\C(=O)NCc1ccccc1)NCCCc1nnc(N)s1 CHEMBL5206565 Kd 0.17 nM
C[C@@H](NC(=O)/N=C(\N)NCCCc1ncn[nH]1)c1ccccc1 CHEMBL5201074 Kd 0.17 nM
CN1CCC=C(c2nsnc2OCCCCCCCCOc2nsnc2C2=CCCN(C)C2)C1 CHEMBL141452 Ki 0.19 nM
O=C(O[C@H]1CN2CCC1CC2)[C@](O)(c1cccs1)C1CCCC1 CHEMBL562642 IC50 0.19 nM
C[C@H]1CN(Cc2cccc(-c3cc(CNC(=O)c4cccc(CC5CCNCC5)c4)ccc3F)c2)CCN1 CHEMBL521523 pA2 0.1995 nM
C(#Cc1ccccc1)CSc1nsnc1[C@H]1CN2CCC[C@H]1C2 CHEMBL100147 EC50 0.2 nM
O=C(O[C@H]1CN2CCC1CC2)C(O)(c1cccs1)c1cccs1 CHEMBL551729 IC50 0.2 nM
O=C(O[C@H]1CN2CCC1CC2)[C@@](O)(c1ccccc1)c1cccs1 CHEMBL564747 IC50 0.2 nM
CN1CCC=C(c2nsnc2OCCCCCCCCCCOc2nsnc2C2=CCCN(C)C2)C1 CHEMBL143468 Ki 0.23 nM
O=C(O[C@H]1CN2CCC1CC2)[C@](O)(c1ccccc1)c1cccs1 CHEMBL556426 IC50 0.23 nM
O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C1(O)c2ccccc2Oc2ccccc21 CHEMBL562890 IC50 0.23 nM
O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C(O)(c1ccsc1)c1ccsc1 CHEMBL551327 IC50 0.23 nM
O=C(Nc1ccc(F)cc1-c1ccc(F)c(Cl)c1)OCC1CCNCC1 CHEMBL4636528 Ki 0.23 nM
CN(C)c1ccc2c(-c3ccc(C(=O)NCCN4CCN(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)CC4)cc3C(=O)[O-])c3ccc(=[N+](C)C)cc-3oc2c1 CHEMBL4756833 pKi 0.2399 nM
O=C(O[C@H]1CN2CCC1CC2)[C@@](O)(c1cccs1)C1CCCC1 CHEMBL554699 IC50 0.24 nM
CN1[C@@H]2CC[C@H]1C[C@@H](OC(=O)C(CO)c1ccccc1)C2 CHEMBL517712 Ki 0.25 nM
C[N+]1(C)CCC[C@H]1[C@H]1CS[C@](c2ccccc2)(C2CCCCC2)O1 CHEMBL376057 Log Ki 0.2512 nM
C[N+]1(C)[C@@H]2CC[C@H]1C[C@@H](CC(O)(c1ccccc1)c1ccccc1)C2 CHEMBL3084658 pA2 0.2512 nM
O=C(O[C@H]1CN2CCC1CC2)C1(O)c2ccccc2-c2ccccc21 CHEMBL563887 IC50 0.26 nM
CN1[C@@H]2CC[C@H]1CC(OC(=O)[C@H](CO)c1ccccc1)C2 CHEMBL2449003 pKi 0.2692 nM
CC1(C(=O)O[C@H]2C[N+]3(CCCOc4ccccc4)CCC2CC3)c2ccccc2Oc2ccccc21 CHEMBL556221 IC50 0.28 nM
O=C(O[C@H]1C[N+]2(CCCCc3ccccc3)CCC1CC2)C(O)(c1cccs1)c1cccs1 CHEMBL554725 IC50 0.29 nM
O=C(O[C@H]1C[N+]2(CCc3ccccc3)CCC1CC2)C1(O)c2ccccc2Oc2ccccc21 CHEMBL564515 IC50 0.29 nM
C[N+]1(C)CCC[C@H]1[C@H]1CSC(c2ccccc2)(c2ccccc2)O1 CHEMBL375969 Log Ki 0.2951 nM
C[N+](C)(C)C[C@H]1COC[C@@](c2ccccc2)(C2CCCCC2)O1 CHEMBL4645580 pKi 0.302 nM
O=C(O[C@H]1CN2CCC1CC2)C1c2ccccc2Oc2ccccc21 CHEMBL549577 IC50 0.31 nM
O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C(O)(c1ccccc1)c1ccccc1 CHEMBL551731 IC50 0.31 nM
Cc1cn2cc(CNC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)Nc3ccc(C(=O)OC4CCCCC4)s3)[n+](Cc3ccc4ccccc4c3)c2s1 CHEMBL540396 pA2 0.3162 nM
CCN(CC)CCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1 CHEMBL295388 pKi 0.3162 nM
CN1CCC=C(c2nsnc2SCCCCCCCCCCSc2nsnc2C2=CCCN(C)C2)C1 CHEMBL143434 Ki 0.32 nM
C[C@@H](c1ccccn1)c1c(CCN(C)C)oc2ccccc12 CHEMBL563920 Ki 0.32 nM
C[N+]1(C)[C@@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@H]1[C@@H]1O[C@@H]12 CHEMBL1354199 Ki 0.321 nM
O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C(c1cccs1)c1cccs1 CHEMBL551063 IC50 0.34 nM
O=C(Nc1ccc(F)cc1-c1cccc(Cl)c1)OCC1CCNCC1 CHEMBL4640703 Ki 0.34 nM
NCCCCCCCCN1CCC(OC(=O)Nc2ccc(F)cc2-c2ccc(F)c(Cl)c2)CC1 CHEMBL5284000 Ki 0.34 nM
CN1CCC[C@@H]1[C@@H]1CS[C@](c2ccccc2)(C2CCCCC2)O1 CHEMBL376870 Log Ki 0.3467 nM
NCCCCCCCCN1CCC(COC(=O)Nc2ccc(F)cc2-c2ccc(F)c(Cl)c2)CC1 CHEMBL5270870 Ki 0.35 nM
O=C(O[C@H]1CN2CCC1CC2)C(O)(c1ccccc1)c1ccccc1 CHEMBL558910 IC50 0.36 nM
O=C(Nc1ccc(F)cc1-c1ccc(F)c(Cl)c1)O[C@H]1CN2CCC1CC2 CHEMBL4640324 Ki 0.36 nM
O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)[C@](O)(c1ccccc1)c1cccs1 CHEMBL564765 IC50 0.38 nM
C[N+]1(C)[C@@H]2CC[C@H]1C[C@@H](C=C(c1cccs1)c1cccs1)C2 CHEMBL3084413 Ki 0.38 nM
CCCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)[nH]c4cc(F)c(C)cc43)CC2)CC1 CHEMBL1223754 pEC50 0.3981 nM
CCO[C@H]1CC[C@](C)(N2CCC(N3C(=O)Cc4ccc(C)cc43)CC2)CC1 CHEMBL1223804 pEC50 0.3981 nM
C/C(C#Cc1cccs1)=C\CO/N=C1\CN2CCC1C2 CHEMBL160858 ED50 0.4 nM
O=C(O[C@H]1C[N+]2(CCOc3ccccc3)CCC1CC2)N(Cc1cccs1)c1ccccc1 CHEMBL1779131 IC50 0.4 nM
O=C(O[C@H]1C[N+]2(CCOc3ccccc3)CCC1CC2)N(Cc1ccsc1)c1ccccc1 CHEMBL1779133 IC50 0.4 nM
O=C(O[C@H]1CN2CCC1CC2)N(Cc1ccccc1)c1ccccc1 CHEMBL1777826 IC50 0.4 nM
O=C(O[C@H]1CN2CCC1CC2)N(Cc1cccs1)c1ccccc1 CHEMBL1779033 IC50 0.4 nM
O=C(O[C@H]1CN2CCC1CC2)N(Cc1ccsc1)c1ccccc1 CHEMBL1779034 IC50 0.4 nM
O=C(N[C@H]1CN2CCC1CC2)[C@](O)(c1cccs1)C1CCCC1 CHEMBL3401643 IC50 0.4 nM
C[N@+]12CC[C@H](CC1)[C@@H](OC(=O)Nc1ccccc1-c1ccccc1)C2 CHEMBL4644192 Ki 0.4 nM
CCCCCCC[N+]12CCC(CC1)[C@@H](OC(=O)C(O)(c1cccs1)c1cccs1)C2 CHEMBL549784 IC50 0.41 nM
C[N+]12CCC(CC1)[C@@H](OC(=O)C(O)(c1cccs1)c1cccs1)C2 CHEMBL560327 IC50 0.43 nM
NCCCCCCN1CCC(COC(=O)Nc2ccc(F)cc2-c2ccc(F)c(Cl)c2)CC1 CHEMBL5281043 Ki 0.43 nM
CC(C)[N+]1(C)C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2 CHEMBL1908368 Ki 0.433 nM
O=C(O[C@H]1C[N+]2(CCc3ccccc3)CCC1CC2)C1c2ccccc2Oc2ccccc21 CHEMBL559106 IC50 0.44 nM
CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1 CHEMBL4851514 pKi 0.4786 nM
C(#Cc1ccccc1)COc1nsnc1[C@H]1CN2CCC[C@H]1C2 CHEMBL98255 EC50 0.5 nM
C[N@+]1(CCF)[C@@H]2CC[C@H]1C[C@@H](OC(=O)C(O)(c1ccccc1)c1ccccc1)C2 CHEMBL5292015 AC50 0.5 nM
C[N+]1(C)CCC[C@@H]1[C@@H]1CS[C@@](c2ccccc2)(C2CCCCC2)O1 CHEMBL222259 Log Ki 0.5012 nM
CN1[C@@H]2CC[C@H]1C[C@@H](CC(O)(c1ccccc1)c1ccccc1)C2 CHEMBL3084662 pKi 0.5012 nM
CCCO[C@H]1CC[C@](C)(N2CCC(N3C(=O)Cc4ccc(C)cc43)CC2)CC1 CHEMBL1223803 pEC50 0.5012 nM
C[N+](C)(C)C[C@H]1COCC(c2ccccc2)(c2ccccc2)O1 CHEMBL2042405 pKi 0.5012 nM
Cc1scc2c1N(C(=O)CN1CCN(CCCCCCCCCCNC(=O)c3ccc(-c4c5ccc(=N)c(S(=O)(=O)O)c-5oc5c(S(=O)(=O)O)c(N)ccc45)c(C(=O)O)c3)CC1)c1ccccc1NC2=O CHEMBL4794548 pKi 0.5012 nM
C[N+](C)(C)CC1COCC(c2ccccc2)(C2CCCCC2)O1 CHEMBL4634230 pKi 0.5248 nM
COc1ccc([S+]([O-])c2ccc(C(C)C3CCN(C4CCCCC4)CC3)cc2)cc1 CHEMBL71124 Ki 0.53 nM
O=C(Nc1ccc(F)cc1-c1ccccc1)O[C@H]1CN2CCC1CC2 CHEMBL4645543 Ki 0.53 nM
O=C(Nc1ccc(F)cc1-c1cccc(Cl)c1)O[C@H]1CN2CCC1CC2 CHEMBL4648071 Ki 0.53 nM
Cc1nccn1CCC(C(N)=O)(c1ccccc1)c1ccccc1 CHEMBL53366 Kb 0.55 nM
O=C(Nc1ccccc1-c1ccccc1)O[C@H]1CN2CCC1CC2 CHEMBL4644670 Ki 0.56 nM
NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1 CHEMBL4636083 pKi 0.5623 nM
CN1CCC=C(c2nsnc2SCCCCCCCCCCCSc2nsnc2C2=CCCN(C)C2)C1 CHEMBL143466 Ki 0.57 nM
NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1 CHEMBL4645845 pKi 0.5888 nM
COc1cc(Br)cc(C2Nc3c(c(C)nn3C)C(=O)CS2)c1 CHEMBL2377266 Ki 0.594 nM
CC(C)c1n(CC2CC(c3ccccc3)(c3ccccc3)C(=O)O2)cc[n+]1C CHEMBL139807 Kb 0.6 nM
CC(C(=O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)(c1cccs1)c1cccs1 CHEMBL561187 IC50 0.6 nM
Cn1cc(-c2ccc(Cn3cc4c(=O)[nH]nc-4c4ccccc43)c(F)c2)cn1 CHEMBL3360954 EC50 0.6 nM
CN1CCC=C(c2nsnc2OCCCCCCOc2nsnc2C2=CCCN(C)C2)C1 CHEMBL142126 Ki 0.61 nM
O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C1(O)c2ccccc2-c2ccccc21 CHEMBL561870 IC50 0.63 nM
C#CCCCCCCN1CCC(OC(=O)Nc2ccc(F)cc2-c2ccc(F)c(Cl)c2)CC1 CHEMBL5270925 Ki 0.63 nM
OC(c1ccccc1)(c1ccccc1)C12CC[N+](CCCOc3ccccc3)(CC1)CC2 CHEMBL524097 Ki 0.64 nM
C#CCCCCCCN1CCC(COC(=O)Nc2ccc(F)cc2-c2ccc(F)c(Cl)c2)CC1 CHEMBL5265833 Ki 0.64 nM
O=C(Nc1ccc(F)cc1-c1ccc(Cl)c(Cl)c1)OCC1CCNCC1 CHEMBL4649201 Ki 0.66 nM
C=C(c1ccc([S@@+]([O-])c2ccc(OC)cc2)cc1)C1CCN(C2CCCCC2)CC1 CHEMBL2114068 Ki 0.68 nM
CN1CCC=C(c2nsnc2SCCCCCCCCCCCCSc2nsnc2C2=CCCN(C)C2)C1 CHEMBL139603 Ki 0.69 nM
C[N+]1(C)CCC[C@@H]1c1ccc([C@](O)(c2ccccc2)C2CCCCC2)o1 CHEMBL569307 pKi 0.6918 nM
O=C(CCCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1 CHEMBL4742721 pKi 0.6918 nM
N=C(N)NCCC[C@@H](N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1 CHEMBL4870127 pKi 0.6918 nM
CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1 CHEMBL4864987 pKi 0.7244 nM
O=C(Nc1ccc(F)cc1-c1ccc(Cl)c(Cl)c1)O[C@H]1CN2CCC1CC2 CHEMBL4643867 Ki 0.73 nM
CC1(C)C(/C=C/C=C/C=C2/N(CCCCS(=O)(=O)O)c3ccccc3C2(C)C)=[N+](CCCCCC(=O)NCCCCCCCCN2CCC(OC(=O)Nc3ccc(F)cc3-c3ccc(F)c(Cl)c3)CC2)c2ccc(S(=O)(=O)[O-])cc21 CHEMBL5271406 Ki 0.73 nM
C[N@+]12CC[C@H](CC1)[C@@H](OC(=O)Nc1ccc(F)cc1-c1ccccc1)C2 CHEMBL4639307 Ki 0.75 nM
CN1CCC[C@@H]1[C@@H]1CSC(c2ccccc2)(c2ccccc2)O1 CHEMBL375073 Log Ki 0.7586 nM
Cc1ccccc1CN1CCC(N2CCC(n3c(=O)[nH]c4ccc(F)cc43)CC2)CC1 CHEMBL490797 EC50 0.76 nM
Cc1cn2cc(CNC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)Nc3ccc(C(=O)OC(C)C)cc3)[n+](Cc3ccc4ccccc4c3)c2s1 CHEMBL539887 pA2 0.7943 nM
C[C@H]1CNCC[C@@H]1CNC(=O)c1c(F)cccc1-c1cccc(Cl)c1 CHEMBL1083925 pEC50 0.7943 nM
C[N+](C)(C)CC1COCC(c2ccccc2)(c2ccccc2)O1 CHEMBL2042404 pKi 0.7943 nM
CN(C)C[C@H]1COC[C@@](c2ccccc2)(C2CCCCC2)O1 CHEMBL4635500 pKi 0.7943 nM
CCCCCN(C(=O)O[C@H]1CN2CCC1CC2)c1ccccc1 CHEMBL1779037 IC50 0.8 nM
CCCCN(Cc1cccs1)C(=O)O[C@H]1CN2CCC1CC2 CHEMBL1779041 IC50 0.8 nM
O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)[C@@](O)(c1cccs1)C1CCCC1 CHEMBL549986 IC50 0.81 nM
CCC(=O)NCc1cc(C(=O)NCCN2CCC(N3CCC(n4c(=O)[nH]c5ccccc54)CC3)CC2)cc(C(=O)NCCN2CCN(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)CC2)c1 CHEMBL4471882 pKd 0.8128 nM
CCN(CC)CCOC(=O)C1(C2CCCCC2)CCCCC1 CHEMBL1123 Ki 0.834 nM
CN1CCC=C(c2nsnc2OCCCCCCCCCOc2nsnc2C2=CCCN(C)C2)C1 CHEMBL143469 Ki 0.84 nM
CCN(CC)CC#CCOC(=O)C(O)(c1ccccc1)C1CCCCC1 CHEMBL1231 Ki 0.847 nM
Cc1ccccc1CN1CCC(N2CCC(n3c(=O)[nH]c4cc(F)ccc43)CC2)CC1 CHEMBL522451 EC50 0.85 nM
CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1 CHEMBL4847898 pKi 0.8511 nM
CN1CCC=C(c2nsnc2SCCCCCCSc2nsnc2C2=CCCN(C)C2)C1 CHEMBL341759 Ki 0.87 nM
CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1 CHEMBL4454300 pKi 0.871 nM
Cc1cccc(CN2CCC(NC(=O)[C@](O)(c3ccccc3)[C@@H]3CCC(F)(F)C3)CC2)c1 CHEMBL146567 Ki 0.88 nM
CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccc(O)cc1 CHEMBL37372 Ki 0.881 nM
O=C(O[C@H]1CN2CCC1CC2)N(Cc1cc(F)c(F)c(F)c1)c1cccc(F)c1 CHEMBL1779046 IC50 0.9 nM
O=C(N[C@H]1CN2CCC1CC2)C(O)(c1cccs1)c1cccs1 CHEMBL3401641 IC50 0.9 nM
CN1CCC[C@@H]1[C@@H]1CS[C@@](c2ccccc2)(C2CCCCC2)O1 CHEMBL219825 Log Ki 0.912 nM
CN1CCC=C(c2nsnc2OCCCCCCCC2CCN(CCCN3C(=O)CCc4ccccc43)CC2)C1 CHEMBL3354068 pKi 0.912 nM
Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1 CHEMBL4754371 pKi 0.912 nM
CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1 CHEMBL4862735 pKi 0.912 nM
CN1CCC=C(c2nsnc2SCCCCSc2nsnc2C2=CCCN(C)C2)C1 CHEMBL142184 Ki 0.93 nM
CN1[C@@H]2CC[C@H]1C[C@H](OC(=O)Nc1ccc(F)cc1-c1ccccc1)C2 CHEMBL4643643 Ki 0.93 nM
N=C(N)NCCC[C@@H](NC1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1)C(=O)O CHEMBL4871700 pKi 0.9333 nM
C[C@](O)(C(=O)O[C@H]1CN2CCC1CC2)c1ccccc1 CHEMBL2115342 Kb 0.95 nM
C[N+]1(C)CCC[C@@H]1[C@@H]1CS[C@](c2ccccc2)(C2CCCCC2)O1 CHEMBL220393 Log Ki 0.955 nM
Cc1cc(/C=C/c2cc3c4c(c2)CCCN4CCC3)cc(C)[n+]1CCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1 CHEMBL4748004 pKi 0.955 nM
CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1 CHEMBL4855492 pKi 0.955 nM
CN1CCN(C2=Nc3cc(Cl)ccc3Nc3ccccc32)CC1 CHEMBL42 Ki 0.98 nM
NC1CCN(C(=O)[C@](O)(c2ccccc2)C2CCCC2)CC1 CHEMBL71431 Ki 0.98 nM
C(#Cc1ccccc1)COc1nsnc1[C@H]1CN2CCC1C2 CHEMBL327269 EC50 0.99 nM
CCCSc1nsnc1OC1CN2CCCC1C2 CHEMBL340435 EC50 1.0 nM
C(#Cc1ccccc1)CSc1nsnc1[C@@H]1CN2CCC[C@H]1C2 CHEMBL316625 EC50 1.0 nM
CCC1(CCN)CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1 CHEMBL443267 Ki 1.0 nM
C[C@H]1CN(Cc2cccc(-c3cc(CNC(=O)c4cccc(CN5CCNCC5)c4)ccc3F)c2)CCN1 CHEMBL492437 pA2 1.0 nM
CCC(=O)c1cccc(C(=O)NCc2ccc(F)c(-c3cccc(CN4CCN[C@@H](C)C4)c3)c2)c1 CHEMBL493266 pA2 1.0 nM
CN1[C@@H]2CC[C@H]1C[C@@H](CC(CO)(c1ccccc1)c1ccccc1)C2 CHEMBL3084679 pKi 1.0 nM
OC(CCC1CCNCC1)c1ccccc1-c1cccc(Cl)c1 CHEMBL1084850 pEC50 1.0 nM
CCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)oc4cc(F)c(C)cc43)CC2)CC1 CHEMBL1223860 pEC50 1.0 nM
O=C(O[C@H]1CN2CCC1CC2)N(CCc1ccccc1)c1ccccc1 CHEMBL1779032 IC50 1.0 nM
Cc1cccc(N(Cc2cc(F)c(F)cc2F)C(=O)O[C@H]2CN3CCC2CC3)c1 CHEMBL1779045 IC50 1.0 nM
O=C(N[C@H]1C[N+]2(CCCc3cccs3)CCC1CC2)C(O)(c1cccs1)c1cccs1 CHEMBL3401649 IC50 1.0 nM
O=C(N[C@H]1C[N+]2(CCCc3ccccc3)CCC1CC2)C(O)(c1cccs1)c1cccs1 CHEMBL3401648 IC50 1.0 nM
CN1/C(=C/C=C/C=C/C2=[N+](CCCCCC(=O)NCCCCCCCCN3CCC(OC(=O)Nc4ccc(F)cc4-c4ccc(F)c(Cl)c4)CC3)c3ccccc3C2(C)C)C(C)(C)c2ccccc21 CHEMBL5289667 Ki 1.0 nM
CN1CCC=C(c2nsnc2OCCCCCCCCCC2CCN(CCCN3C(=O)CCc4ccccc43)CC2)C1 CHEMBL3354069 pKi 1.023 nM
O=c1[nH]c2cc(F)ccc2n1C1CCN(C2CCN(Cc3ccccc3C(F)(F)F)CC2)CC1 CHEMBL489576 EC50 1.04 nM
Cc1ccccc1CN1CCC(N2CCC(n3c(=O)[nH]c4c(F)cccc43)CC2)CC1 CHEMBL490598 EC50 1.06 nM
C[N+](C)(CC#CCOC1=NOCC1)Cc1cc(F)c(/N=N/c2c(F)cc(C[N+](C)(C)CC#CCOC3=NOCC3)cc2F)c(F)c1 CHEMBL4466914 pIC50 1.072 nM
C[N+](C)(C)C[C@@H]1CS[C@@](c2ccccc2)(C2CCCCC2)O1 CHEMBL45454 Log Ki 1.096 nM
CCCCCCSc1nccnc1O[C@H]1CN2CCC1C2 CHEMBL542622 EC50 1.1 nM
CC(=O)OCC[N+](C)(C)C CHEMBL667 EC50 1.1 nM
O=C(O[C@H]1C[N+]2(CCOc3ccccc3)CCC1CC2)N(Cc1cc(F)c(F)c(F)c1)c1cccc(F)c1 CHEMBL1779140 IC50 1.1 nM
CCCCN(C(=O)O[C@H]1CN2CCC1CC2)c1ccccc1 CHEMBL1779036 IC50 1.1 nM
C[N+]1(C)CCC(OC(=O)C(c2ccccc2)c2ccccc2)CC1 CHEMBL76897 Ki 1.1 nM
CN1[C@@H]2C[C@H](OC(=O)Nc3ccc(F)cc3-c3ccccc3)C[C@H]1[C@@H]1O[C@@H]12 CHEMBL4639938 Ki 1.1 nM
C[N+]1(C)CCC(COC(=O)Nc2ccc(F)cc2-c2ccc(F)c(Cl)c2)CC1 CHEMBL4645235 Ki 1.1 nM
O=C(O[C@H]1C[N+]2(CCc3ccccc3)CCC1CC2)C1(O)c2ccccc2-c2ccccc21 CHEMBL562655 IC50 1.12 nM
O=C1CCCN1CC#CCN1CCCC1 CHEMBL7634 Log Ki 1.122 nM
CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1 CHEMBL4871153 pKi 1.148 nM
CC(=O)NC(=O)[C@H](CCNC(=N)N)NC(=O)[C@@H]1CC(=O)NCCC[C@@H](C(=O)NCCN2CCN(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)CC2)N1 CHEMBL4876725 pKi 1.148 nM
CN1CCC=C(c2nsnc2SCCCSc2nsnc2C2=CCCN(C)C2)C1 CHEMBL337131 Ki 1.2 nM
O=C(NC1CCN(Cc2cccc(O)c2)CC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1 CHEMBL145913 Ki 1.2 nM
CN1C[C@H](CNC(=O)OCc2ccccc2)C[C@@H]2c3cccc4c3c(cn4C)C[C@H]21 CHEMBL19215 Activity 1.2 nM
O=c1[nH]nc2c3ccccc3n(Cc3ccc(-n4cccn4)cc3)cc1-2 CHEMBL3360955 EC50 1.2 nM
CN1CCCC1c1ccc(C(O)(c2ccccc2)C2CCCCC2)o1 CHEMBL583051 pKi 1.23 nM
CN1CCC[C@@H]1c1ccc([C@](O)(c2ccccc2)C2CCCCC2)o1 CHEMBL571121 pKi 1.23 nM
CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1 CHEMBL4540949 pKi 1.23 nM
C[N+]1(C)[C@@H]2CC[C@H]1C[C@@H](CC(CO)(c1ccccc1)c1ccccc1)C2 CHEMBL3084643 pKi 1.259 nM
CCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)oc4c(F)cc(C)cc43)CC2)CC1 CHEMBL1223861 pEC50 1.259 nM
CN(C)C[C@H]1COCC(c2ccccc2)(c2ccccc2)O1 CHEMBL2042553 pKi 1.259 nM
CN(C)C[C@H]1COCC(c2ccccc2)(c2ccccc2)O1 CHEMBL2078942 pKi 1.259 nM
C[N+](C)(C)CC#CCOC1=NOCC1 CHEMBL3121473 pIC50 1.259 nM
CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1 CHEMBL4554682 pKi 1.259 nM
CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1 CHEMBL4856113 pKi 1.259 nM
CC(=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCNC(=N)N)N[C@@H](CCCN)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1 CHEMBL4874955 pKi 1.259 nM
CC1(C(=O)O[C@H]2C[N+]3(CCCOc4ccccc4)CCC2CC3)c2ccccc2-c2ccccc21 CHEMBL559931 IC50 1.26 nM
CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NC1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1 CHEMBL4861252 pKi 1.288 nM
CCN(CC)CCSC(=O)C(O)(c1ccccc1)c1ccccc1 CHEMBL2377387 Ki 1.29 nM
OC(CCN1CCCCC1)(c1ccccc1)C1CCCCC1 CHEMBL1092 IC50 1.3 nM
NCC=C1CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1 CHEMBL68384 Ki 1.3 nM
CC(c1ccc(S(=O)(=O)c2ccccc2)cc1)N1CCN(C2CCCCC2)CC1 CHEMBL312085 Ki 1.3 nM
C#CCCCCCN1CCC(COC(=O)Nc2ccc(F)cc2-c2ccc(F)c(Cl)c2)CC1 CHEMBL5279174 Ki 1.3 nM
CCN(CC)CCOC(=O)C(O)(c1cccs1)C1CCCCC1 CHEMBL2377267 Ki 1.32 nM
Cc1cc(/C=C/c2cc3c4c(c2)CCCN4CCC3)cc(C)[n+]1CCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1 CHEMBL4744233 pKi 1.349 nM
N=C(N)NCCC[C@H](N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1 CHEMBL4864727 pKi 1.349 nM
OC(CCN1CCCCC1)(c1ccccc1)C1CCCCC1 CHEMBL1490 Ki 1.351 nM
CN1CCC[C@H]1[C@H]1CS[C@@](c2ccccc2)(C2CCCCC2)O1 CHEMBL385328 Log Ki 1.38 nM
CN(C)CC1COCC(c2ccccc2)(C2CCCCC2)O1 CHEMBL4649224 pKi 1.38 nM
CCCCCCOc1nccnc1OC1CN2CCC1C2 CHEMBL300998 ED50 1.4 nM
Cc1cccc(CN2CCC(NC(=O)C(O)(c3ccccc3)C3CCCC3)CC2)c1 CHEMBL358726 Ki 1.4 nM
Cc1ccc(O)c([C@H](CCN(C(C)C)C(C)C)c2ccccc2)c1 CHEMBL1382 Ki 1.4 nM
CCCCN(C(=O)O[C@H]1C[N+]2(CCOc3ccccc3)CCC1CC2)c1ccccc1 CHEMBL1779137 IC50 1.4 nM
O=C(O[C@H]1C[N+]2(CCCc3cccs3)CCC1CC2)N(Cc1ccccc1)c1ccccc1 CHEMBL1779128 IC50 1.4 nM
CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1 CHEMBL4569639 pKi 1.413 nM
CN1CC=C(c2nsnc2OCCCN2CCN(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)CC2)CC1 CHEMBL4455570 pKi 1.445 nM
CN1CCC[C@H]1[C@H]1CS[C@](c2ccccc2)(C2CCCCC2)O1 CHEMBL376255 Log Ki 1.479 nM
CN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1 CHEMBL9967 pIC50 1.479 nM
CN1CCC=C(c2nsnc2OCCOCCOCCOCCOCCOc2nsnc2C2=CCCN(C)C2)C1 CHEMBL140142 Ki 1.5 nM
Nc1cccc(CN2CCC(NC(=O)[C@](O)(c3ccccc3)[C@@H]3CCC(F)(F)C3)CC2)n1 CHEMBL69678 Ki 1.5 nM
CC1(CCN)CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1 CHEMBL302809 Ki 1.5 nM
O=C(O[C@H]1CN2CCC1CC2)N(Cc1cccc(F)c1)c1cccc(F)c1 CHEMBL1779044 IC50 1.5 nM
O=C(O[C@H]1C[N+]2(CCCc3ccccc3)CCC1CC2)N(Cc1ccccc1)c1ccccc1 CHEMBL1779049 IC50 1.5 nM
CN(C)c1ccc2c(-c3ccc(-c4cn(CCCCCn5cc(CCCCCCN6CCC(COC(=O)Nc7ccc(F)cc7-c7ccc(F)c(Cl)c7)CC6)nn5)nn4)cc3C(=O)[O-])c3ccc(=[N+](C)C)cc-3oc2c1 CHEMBL5285607 Ki 1.5 nM
CN1[C@@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@H]1[C@@H]1O[C@@H]12 CHEMBL569713 AC50 1.5 nM
CN1[C@@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@H]1[C@@H]1O[C@H]12 CHEMBL1187846 pIC50 1.514 nM
CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1 CHEMBL4097258 pKi 1.514 nM
C[C@H](NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1)C(=O)NC(=O)[C@@H](N)CCCN CHEMBL4859378 pKi 1.514 nM
CN1CCCC[C@@H]1/C=C/C1c2ccccc2Cc2ccccc21 CHEMBL22829 Kd 1.53 nM
CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21 CHEMBL265256 Log Ki 1.585 nM
CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CCCCCCNCC(=O)N1c2ncccc2NC(=O)c2cccnc21 CHEMBL4448108 pKi 1.585 nM
CC[N+](C)(CC)CCOC(=O)C(O)(c1ccccc1)c1ccccc1 CHEMBL2106570 Ki 1.59 nM
CN1CCC=C(c2nsnc2OCCCCCCCCCCCCOc2nsnc2C2=CCCN(C)C2)C1 CHEMBL142538 Ki 1.6 nM
C[N+]1(C)[C@@H]2CC[C@H]1C[C@@H](OC(=O)N(Cc1ccsc1)c1ccsc1)C2 CHEMBL3085073 IC50 1.6 nM
O=C(O[C@H]1C[N+]2(CCCc3cccs3)CCC1CC2)N(Cc1cccs1)c1ccccc1 CHEMBL1777827 IC50 1.6 nM
NCc1cc(C(=O)NCCN2CCC(N3CCC(n4c(=O)[nH]c5ccccc54)CC3)CC2)cc(C(=O)NCCN2CCN(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)CC2)c1 CHEMBL4641328 pKi 1.622 nM
CSc1ccc2c(c1)N(CCC1CCCCN1C)c1ccccc1S2 CHEMBL479 Ki 1.69 nM
Cc1cc(OCCN(C)C)nc2ccc(NC(=O)COc3ccc(Cl)cc3Cl)cc12 CHEMBL194837 IC50 1.7 nM
O=C(O[C@H]1C[N+]2(CCOc3ccccc3)CCC1CC2)N(Cc1ccccc1)c1ccccc1 CHEMBL1779129 IC50 1.7 nM
O=c1[nH]c2c(F)cccc2n1C1CCN(C2CCN(Cc3ccccc3C(F)(F)F)CC2)CC1 CHEMBL521914 EC50 1.71 nM
CN1CCCCC1/C=C/C1c2ccccc2Cc2ccccc21 CHEMBL21942 Kd 1.75 nM
COc1ccc(Cn2cc(C(=O)O)c(=O)c3c(F)ccc(F)c32)cc1 CHEMBL594432 pEC50 1.778 nM
CN(C)c1ccc2c(-c3ccc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc3C(=O)[O-])c3ccc(=[N+](C)C)cc-3oc2c1 CHEMBL4789147 pKi 1.778 nM
NCC1CCN(C(=O)[C@](O)(c2ccccc2)C2CCCC2)CC1 CHEMBL66400 Ki 1.8 nM
CN(C)C1(CNCCC2CCOCC2)COc2cc(Cl)c(Cl)cc2OC1 CHEMBL234440 Ki 1.8 nM
C[N+]1(C)CCC(COC(=O)Nc2ccc(F)cc2-c2cccc(Cl)c2)CC1 CHEMBL4636887 Ki 1.8 nM
O=C(Nc1ccccc1-c1ccccc1)OCC1CCNCC1 CHEMBL4636302 Ki 1.8 nM
CN1/C(=C/C=C/C=C/C2=[N+](CCCCCC(=O)NCCCCCCCCN3CCC(COC(=O)Nc4ccc(F)cc4-c4ccc(F)c(Cl)c4)CC3)c3ccccc3C2(C)C)C(C)(C)c2ccccc21 CHEMBL5289601 Ki 1.8 nM
CCCSc1nsnc1OC1CN2CCC1C2 CHEMBL126846 EC50 1.9 nM
CN(C)CCCOC(=O)C(C)(c1ccccc1)C1CCCCC1 CHEMBL286008 Ki 1.9 nM
CN1CCC=C(c2nsnc2OCCOCCOCCOCCOCCOCCOc2nsnc2C2=CCCN(C)C2)C1 CHEMBL139887 Ki 1.9 nM
NCCCCCCN1CCC(OC(=O)Nc2ccc(F)cc2-c2ccc(F)c(Cl)c2)CC1 CHEMBL5282659 Ki 1.9 nM
CN1/C(=C/C=C/C=C/C2=[N+](CCCCCC(=O)NCCCNCCCCCCN3CCC(COC(=O)Nc4ccc(F)cc4-c4ccc(F)c(Cl)c4)CC3)c3ccccc3C2(C)C)C(C)(C)c2ccccc21 CHEMBL5289083 Ki 1.9 nM
C[C@H]1CN(Cc2cccc(-c3cc(CNC(=O)c4cccc(CN5CC[N+](C)(C)CC5)c4)ccc3F)c2)CCN1 CHEMBL555476 pA2 1.995 nM
CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1 CHEMBL4852186 pKi 1.995 nM
CN(C)CCc1sc2ccccc2c1Cc1ccc(F)cc1 CHEMBL540982 Ki 2.0 nM
O=C(O[C@H]1C[N+]2(CCCc3cccs3)CCC1CC2)N(Cc1ccsc1)c1ccccc1 CHEMBL1779132 IC50 2.0 nM
CCCCN(C(=O)O[C@H]1C[N+]2(CCCc3cccs3)CCC1CC2)c1ccccc1 CHEMBL1779136 IC50 2.0 nM
O=C(OCCN1CCCC1)N1c2ccccc2Sc2ccccc21 CHEMBL481153 Ki 2.0 nM
CN1CCC(=C2c3ccccc3CCc3sccc32)CC1 CHEMBL294951 Ki 2.0 nM
O=C(OC1CN2CCC1CC2)N(CCc1ccc(F)cc1)c1ccccc1 CHEMBL4519301 Ki 2.0 nM
C#CCCCCCN1CCC(OC(=O)Nc2ccc(F)cc2-c2ccc(F)c(Cl)c2)CC1 CHEMBL5287315 Ki 2.0 nM
CN(C)c1ccc2c(-c3ccc(-c4cn(CCCCCn5cc(CCCCCCN6CCC(OC(=O)Nc7ccc(F)cc7-c7ccc(F)c(Cl)c7)CC6)nn5)nn4)cc3C(=O)[O-])c3ccc(=[N+](C)C)cc-3oc2c1 CHEMBL5267836 Ki 2.0 nM
C[N+]1(C)CCCC1c1ccc(C(O)(c2ccccc2)C2CCCCC2)o1 CHEMBL569760 pKi 2.089 nM
CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccccc1 CHEMBL26505 Ki 2.1 nM
Cc1cc2c(s1)Nc1ccccc1N=C2N1CCN(C)CC1 CHEMBL715 Ki 2.1 nM
Cc1cc(CN2CCC(NC(=O)C(O)(c3ccccc3)C3CCCC3)CC2)cs1 CHEMBL356305 Ki 2.1 nM
NCCC1CCN(C(=O)[C@](O)(c2ccccc2)C2CCCC2)CC1 CHEMBL69648 Ki 2.1 nM
NCC1CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)C1 CHEMBL305531 Ki 2.1 nM
C[N+]1(C)[C@@H]2CC[C@H]1C[C@H](OC(=O)N(Cc1ccccc1)c1ccsc1)C2 CHEMBL3085072 IC50 2.1 nM
CCOC(=O)N1CCC(N2CCC(n3c(=O)[nH]c4ccccc43)CC2)CC1 CHEMBL491209 EC50 2.1 nM
O=C(N[C@H]1C[N+]2(CCOc3ccccc3)CCC1CC2)C(O)(c1cccs1)c1cccs1 CHEMBL3401650 IC50 2.1 nM
O=C(Nc1ccc(F)cc1-c1ccccc1)OCC1CCNCC1 CHEMBL4644852 Ki 2.1 nM
CC(C)[N+]1(C)[C@@H]2CC[C@H]1C[C@@H](OC(=O)C(CO)c1ccccc1)C2 CHEMBL1621597 Ki 2.11 nM
CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1 CHEMBL4451383 pKi 2.138 nM
C=C(c1ccc([S@+]([O-])c2ccc(OC)cc2)cc1)C1CCN(C2CCCCC2)CC1 CHEMBL2115128 Ki 2.14 nM
CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1 CHEMBL4589047 pKi 2.291 nM
CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1 CHEMBL4582879 pKi 2.291 nM
CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21 CHEMBL4636899 pKi 2.291 nM
CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCN4CCC(N5CCC(n6c(=O)[nH]c7ccccc76)CC5)CC4)cc(C(=O)NCCN4CCN(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)CC4)c3)c3ccc(S(=O)(=O)[O-])cc3C2(C)C)=[N+](CCCCS(=O)(=O)O)c2ccccc21 CHEMBL4643273 pKi 2.291 nM
CN1/C(=C/C=C/C=C/C2=[N+](CCCCCC(=O)NCCCCCCN3CCC(COC(=O)Nc4ccc(F)cc4-c4ccc(F)c(Cl)c4)CC3)c3ccccc3C2(C)C)C(C)(C)c2ccccc21 CHEMBL5273907 Ki 2.3 nM
C[N+]1(C)CCC[C@@H]1[C@@H]1CSC(c2ccccc2)(c2ccccc2)O1 CHEMBL375851 Log Ki 2.344 nM
CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1 CHEMBL4515788 pKi 2.344 nM
OC(CCN1CCCCC1)(c1ccccc1)C1CC2C=CC1C2 CHEMBL1101 Ki 2.36 nM
CC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1 CHEMBL4568151 pKi 2.399 nM
O=C(NC1CCN(Cc2ccccc2)CC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1 CHEMBL147653 Ki 2.4 nM
C[N+]1(C)[C@@H]2CC[C@H]1C[C@H](OC(=O)N(Cc1cccs1)c1ccccc1)C2 CHEMBL3085059 IC50 2.4 nM
C[C@H](C1=C(CCN(C)C)Cc2ccccc21)c1ccccn1 CHEMBL564226 Ki 2.4 nM
Cc1cccc(N(Cc2cc(F)c(F)cc2F)C(=O)O[C@H]2C[N+]3(CCOc4ccccc4)CCC2CC3)c1 CHEMBL1779139 IC50 2.4 nM
O=C(O[C@H]1CN2CCC1CC2)N(Cc1cccs1)Cc1cccs1 CHEMBL1779040 IC50 2.4 nM
CCN(CC)CC#CCOC(=O)C(O)(c1ccccc1)C1CCCCC1 CHEMBL1133 Kb 2.45 nM
Nc1ccc(CN2CCC(NC(=O)[C@](O)(c3ccccc3)[C@@H]3CCC(F)(F)C3)CC2)cc1F CHEMBL356181 Ki 2.5 nM
O=C(NC1CCN(Cc2cccc(F)c2)CC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1 CHEMBL147611 Ki 2.5 nM
Fc1cccc(C#CCSc2nsnc2C23CN4CC2C3C4)c1 CHEMBL293982 EC50 2.5 nM
CCCCN(C(=O)O[C@H]1C[N+]2(CCCc3ccccc3)CCC1CC2)c1ccccc1 CHEMBL1779135 IC50 2.5 nM
C[N+]1(Cc2ccc(O)cc2)CCC[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)Nc2ccc(C(=O)OC3CCCCC3)s2)C1 CHEMBL553448 pA2 2.512 nM
CC(=O)c1cccc(C(=O)NCc2ccc(F)c(-c3cccc(CN4CCN[C@@H](C)C4)c3)c2)c1 CHEMBL493265 pA2 2.512 nM
CCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)oc4ccc(OC)cc43)CC2)CC1 CHEMBL1223862 pEC50 2.512 nM
CCCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)oc4ccc(S(C)(=O)=O)cc43)CC2)CC1 CHEMBL1223939 pEC50 2.512 nM
COCCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)oc4ccc(C)cc43)CC2)CC1 CHEMBL1223940 pEC50 2.512 nM
CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1 CHEMBL4597498 pKi 2.512 nM
NC1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1 CHEMBL4878646 pKi 2.57 nM
C[n+]1ccn(CC2CC(c3ccccc3)(c3ccccc3)C(=O)O2)c1C(C)(C)C CHEMBL139866 Kb 2.6 nM
O=C(NC1CCN(Cc2ccccc2)CC1)C(O)(c1ccccc1)C1CCCC1 CHEMBL146464 Ki 2.6 nM
C[N+]1(C)[C@@H]2CC[C@H]1C[C@@H](OC(=O)N(Cc1ccsc1)c1ccccc1)C2 CHEMBL3085060 IC50 2.6 nM
CN1CCCCC1CC=C1c2ccccc2Cc2ccccc21 CHEMBL418189 Kd 2.7 nM
C[N+]1(C)[C@@H]2CC[C@H]1C[C@H](OC(=O)N(Cc1ccccc1)c1cccs1)C2 CHEMBL3085071 IC50 2.7 nM
CN1/C(=C/C=C/C=C/C2=[N+](CCCCCC(=O)NCCCCCCN3CCC(OC(=O)Nc4ccc(F)cc4-c4ccc(F)c(Cl)c4)CC3)c3ccccc3C2(C)C)C(C)(C)c2ccccc21 CHEMBL5277670 Ki 2.7 nM
O=C(O[C@H]1C[C@H]2CC[C@@H](C1)[N+]21CCCC1)C(O)(c1ccccc1)c1ccccc1 CHEMBL1888176 AC50 2.7 nM
CN(C)CCC=C1c2ccccc2CCc2ccccc21 CHEMBL629 Ki 2.724 nM
CCC(C)C(C(=O)OCC[N+](C)(CC)CC)c1ccccc1 CHEMBL2107687 Ki 2.78 nM
C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCCCC2)CC1 CHEMBL71147 Ki 2.8 nM
O=C(Nc1ccc(F)cc1-c1ccc(F)c(Cl)c1)OC1CCNCC1 CHEMBL5274390 Ki 2.8 nM
CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21 CHEMBL4641726 pKi 2.884 nM
CCN(CC)CCCOC(=O)C(C)(c1ccccc1)C1CCCCC1 CHEMBL284137 Ki 2.9 nM
CC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1 CHEMBL4567026 pKi 2.951 nM
Cc1cc(NCCN2C3CCCC2CC3)nnc1-c1ccccc1O CHEMBL281456 Ki 3.0 nM
CC(C)(C)c1nccn1CC1CC(c2ccccc2)(c2ccccc2)C(=O)O1 CHEMBL554836 Kb 3.0 nM
CCCCOc1nsnc1C1=CCCN(C)C1 CHEMBL101054 IC50 3.0 nM
NC1CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1 CHEMBL68584 Ki 3.0 nM
Cc1cccc(N(Cc2cc(F)c(F)cc2F)C(=O)O[C@H]2C[N+]3(CCCc4ccccc4)CCC2CC3)c1 CHEMBL1779138 IC50 3.0 nM
O=C(Nc1ccccc1-c1ccccc1)OC12CCN(CC1)CC2 CHEMBL1779047 IC50 3.0 nM
CC[N+]1(C)[C@@H]2CC(OC(=O)[C@H](CO)c3ccccc3)C[C@H]1[C@@H]1O[C@@H]12 CHEMBL4297364 AC50 3.0 nM
CC(C)[N+](C)(CCOC(=O)C1c2ccccc2Oc2ccccc21)C(C)C CHEMBL1180725 AC50 3.0 nM
CC[N+](C)(CC)CCOC(=O)C(O)(c1ccccc1)C1CCCCC1 CHEMBL1201286 AC50 3.0 nM
C[N+]1(C)CCC[C@H]1[C@H]1C[S+]([O-])[C@@](c2ccccc2)(C2CCCCC2)O1 CHEMBL539120 pKi 3.02 nM
Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1 CHEMBL4650998 pKi 3.02 nM
CCCCCCC[N+]12CCC(CC1)[C@@H](OC(=O)C1(O)c3ccccc3-c3ccccc31)C2 CHEMBL563996 IC50 3.1 nM
C[N+]12CCC(CC1)C(OC(=O)C(O)(c1ccccc1)c1ccccc1)C2 CHEMBL620 AC50 3.1 nM
O=C(NCC1=CCNCC1)c1c(F)cccc1-c1cccc(Cl)c1 CHEMBL1083618 pEC50 3.162 nM
CO[C@H]1CC[C@](C)(N2CCC(N3C(=O)Cc4ccc(C)cc43)CC2)CC1 CHEMBL1223805 pEC50 3.162 nM
CCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)oc4ccc(C#N)cc43)CC2)CC1 CHEMBL1223863 pEC50 3.162 nM
CC(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1 CHEMBL4548432 pKi 3.162 nM
Nc1cccc(CN2CCC(NC(=O)[C@](O)(c3ccccc3)[C@@H]3CCC(F)(F)C3)CC2)c1 CHEMBL422665 Ki 3.2 nM
COc1ccc(F)cc1C1CCN([C@@H]2CCC3(C2)CN(C(=O)C2COC2)C3)CC1 CHEMBL5399732 EC50 3.2 nM
O=C(Nc1ccc(F)cc1-c1cc(Cl)cc(Cl)c1)OCC1CCNCC1 CHEMBL4644999 Ki 3.3 nM
CC(CN1c2ccccc2Sc2ccccc21)N(C)C CHEMBL643 Ki 3.321 nM
CN1CCCCC1/C=C/C1c2ccccc2OC2C=CC=CC21 CHEMBL25334 Kd 3.35 nM
CC1CCC[n+]2ccn(CC3CC(c4ccccc4)(c4ccccc4)C(=O)O3)c21 CHEMBL138818 Kb 3.4 nM
Cc1cncn1CCC(C(N)=O)(c1ccccc1)c1ccccc1 CHEMBL50748 Kb 3.4 nM
CN1CCC[C@H]1[C@H]1CSC(c2ccccc2)(c2ccccc2)O1 CHEMBL373515 Log Ki 3.467 nM
O=C(O[C@H]1C[C@H]2CC[C@@H](C1)[N+]21CCCC1)C(O)(c1ccccc1)c1ccccc1 CHEMBL3084748 pKi 3.467 nM
Cc1ccc(CN2CCC(NC(=O)C(O)(c3ccccc3)C3CCCC3)CC2)cc1 CHEMBL149486 Ki 3.5 nM
Nc1ccc(CN2CCC(NC(=O)[C@](O)(c3ccccc3)[C@@H]3CCC(F)(F)C3)CC2)cc1 CHEMBL343449 Ki 3.5 nM
O=C(Nc1ccccc1-c1cc(F)c(F)c(F)c1)OCC1CCNCC1 CHEMBL4640544 Ki 3.5 nM
Cc1ccsc1CN(C(=O)O[C@H]1C[C@H]2CC[C@@H](C1)[N+]2(C)C)c1ccccc1 CHEMBL3085068 IC50 3.8 nM
CN(C)c1ccc2c(-c3ccc(-c4cn(CCCCCn5cc(CCCCCN6CCC(COC(=O)Nc7ccc(F)cc7-c7ccc(F)c(Cl)c7)CC6)nn5)nn4)cc3C(=O)[O-])c3ccc(=[N+](C)C)cc-3oc2c1 CHEMBL5268503 Ki 3.8 nM
CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1 CHEMBL4876453 pKi 3.802 nM
N=C(N)NCCCCC(=O)NC1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1 CHEMBL4878717 pKi 3.89 nM
CN1CCC(=C2c3ccccc3C=Cc3ccccc32)CC1 CHEMBL516 Ki 3.943 nM
CC(=O)OCCCCCCCCCCCCOc1nsnc1C1=CCCN(C)C1 CHEMBL538793 Log Ki 3.981 nM
CCN(CC)CCOC(=O)C(C)(c1ccccc1)C1CCCCC1 CHEMBL443780 Ki 4.0 nM
Cc1n(CC2CC(c3ccccc3)(c3ccccc3)C(=O)O2)cc[n+]1Cc1ccccc1 CHEMBL343085 Kb 4.0 nM
O=C(CCC1=[N+]2C(=Cc3ccc(-c4cccs4)n3[B-]2(F)F)C=C1)NCCOCCOCCOCCOCCOCCOCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1 CHEMBL2368392 Kd 4.1 nM
CN(C)c1ccc2c(-c3ccc(-c4cn(CCCCCn5cc(CCCCCN6CCC(OC(=O)Nc7ccc(F)cc7-c7ccc(F)c(Cl)c7)CC6)nn5)nn4)cc3C(=O)[O-])c3ccc(=[N+](C)C)cc-3oc2c1 CHEMBL5283759 Ki 4.1 nM
C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](CC[C@H]3CCC[C@H](C)N3C)[C@@H]12 CHEMBL355854 Ki 4.3 nM
COc1cccc(CN2CCC(NC(=O)[C@](O)(c3ccccc3)[C@@H]3CCC(F)(F)C3)CC2)c1 CHEMBL149484 Ki 4.4 nM
C=C(c1ccc(Sc2ccc(OC)cc2)cc1)C1CCN(C2CCCCC2)CC1 CHEMBL70828 Ki 4.4 nM
O=C(N[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C(O)(c1cccs1)c1cccs1 CHEMBL3401651 IC50 4.4 nM
C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](/C=C/[C@H]3CCC[C@H](C)N3C)[C@@H]12 CHEMBL277642 Ki 4.5 nM
Fc1ccc(C#CCSc2nsnc2C23CN4CC2C3C4)cc1 CHEMBL418491 EC50 4.5 nM
C[N+]1(C)[C@@H]2CC[C@H]1C[C@H](OC(=O)N(Cc1ccccc1)c1ccccc1)C2 CHEMBL3085058 IC50 4.5 nM
CN(C)CC1COCC(c2ccccc2)(c2ccccc2)O1 CHEMBL2042552 pKi 4.571 nM
c1ccc(C2(c3ccccc3)COC[C@H](CO[C@@H]3CN4CCC3CC4)O2)cc1 CHEMBL4128341 pKi 4.571 nM
CC(=O)OC1CC2CCCC1N2 CHEMBL64000 Ki 4.6 nM
CC(C)N(CC[C@H](c1ccccc1)c1cc(CCNC(=O)CCCCCNC(=O)COc2ccc(/C=C/C3=[N+]4C(=Cc5ccc(-c6cccs6)n5[B-]4(F)F)C=C3)cc2)ccc1O)C(C)C CHEMBL271108 Ki 4.6 nM
CC1(N)CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1 CHEMBL68609 Ki 4.7 nM
O=C(Nc1ccc(F)cc1-c1ccc(F)cc1)OCC1CCNCC1 CHEMBL4648196 Ki 4.8 nM
CN1CCC=C(c2nsnc2OCCOCCOc2nsnc2C2=CCCN(C)C2)C1 CHEMBL142766 Ki 4.9 nM
Fc1cccc(C#CCOc2nsnc2C23CN4CC2C3C4)c1 CHEMBL304247 EC50 4.9 nM
O=C(N[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C1c2ccccc2Oc2ccccc21 CHEMBL3401654 IC50 4.9 nM
CN1CCCC[C@H]1/C=C/C1c2ccccc2Cc2ccccc21 CHEMBL415038 Kd 4.92 nM
CN1CCCCC1CCC=C1c2ccccc2Cc2ccccc21 CHEMBL22278 Kd 4.99 nM
CN1CCC=C(c2nsnc2SCCCCCCCCSc2nsnc2C2=CCCN(C)C2)C1 CHEMBL140789 Ki 5.0 nM
CC(C)=CCn1c(N2CCC[C@@H](N)C2)nc2c1c(=O)n(Cc1nccc3ccccc13)c(=O)n2C CHEMBL429450 IC50 5.0 nM
Cc1cc2c(cc1F)[nH]c(=O)n2C1CCN(C2CCOCC2)CC1 CHEMBL1223753 pEC50 5.012 nM
Cc1ccc2[nH]c(=O)n(C3CCN(C4CCOCC4)CC3)c2c1 CHEMBL2146599 pEC50 5.012 nM
C[N+](C)(CC#CCOC1=NOCC1)Cc1cc(F)c(/N=N\c2c(F)cc(C[N+](C)(C)CC#CCOC3=NOCC3)cc2F)c(F)c1 CHEMBL4514215 pIC50 5.012 nM
C[N+](C)(C)C[C@@H]1COC[C@](c2ccccc2)(C2CCCCC2)O1 CHEMBL4648939 pKi 5.012 nM
CN1CCCCC1C/C=C/C1c2ccccc2Cc2ccccc21 CHEMBL22071 Kd 5.23 nM
CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21 CHEMBL4644612 pKi 5.248 nM
O=C(NC1CCN(Cc2ccsc2)CC1)[C@](O)(c1ccccc1)[C@@H]1CCC(F)(F)C1 CHEMBL356505 Ki 5.3 nM
C[C@@H](c1ccccn1)c1c(CCN(C)C)sc2ccccc12 CHEMBL564144 Ki 5.3 nM
O=C(Nc1ccc(F)cc1-c1ccccc1)N[C@H]1CN2CCC1CC2 CHEMBL4632615 Ki 5.3 nM
OC(c1ccccc1)(c1ccccc1)C12CC[N+](CCOCc3ccccc3)(CC1)CC2 CHEMBL1187833 AC50 5.3 nM
NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(CCc2ccc3c(c2)CCO3)C1 CHEMBL1346 Ki 5.5 nM
CC(c1ccncc1)c1c(CCN(C)C)sc2ccccc12 CHEMBL1091790 Ki 5.6 nM
CC[N+](CC)(CC)CCOC(=O)C(c1ccccc1)c1ccccc1 CHEMBL2377383 Ki 5.75 nM
CC[N+](C)(CC)CCOC(=O)C(c1ccccc1)c1ccccc1 CHEMBL2377385 Ki 5.78 nM
C[N+]1(C)[C@@H]2CC[C@H]1C[C@H](OC(=O)N(CC1CCCCC1)c1ccsc1)C2 CHEMBL3085074 IC50 5.8 nM
C[C@@H](c1ccccn1)c1c(CCN2CCCC2)sc2ccccc12 CHEMBL1091774 Ki 5.8 nM
CC1CN(C(=O)CCS(=O)(=O)c2cccc3ncsc23)CCN1c1ccc(C#N)cn1 CHEMBL4799006 IC50 5.8 nM
N#Cc1ccc(N2CCN(C(=O)CCS(=O)(=O)c3cccc4ncsc34)CC2)nc1 CHEMBL4760610 IC50 5.8 nM
CN(C)C1(CNCCC23CC4CC(CC(C4)C2)C3)COc2ccccc2OC1 CHEMBL394137 Ki 5.9 nM
NC(=O)C(CCn1ccnc1)(c1ccccc1)c1ccccc1 CHEMBL300308 Kb 5.99 nM
CN1CCN(C2=Nc3ccccc3Nc3ccc(Cl)cc32)CC1 CHEMBL415300 IC50 6.0 nM
COc1ccc([S+]([O-])c2ccc(C(C)N3CCN(C4CCCCC4)CC3)cc2)cc1 CHEMBL307810 Ki 6.0 nM
COc1ccc(S(=O)(=O)c2ccc(C(C)N3CCN(C4CCCCC4)CC3)cc2)cc1 CHEMBL310912 Ki 6.0 nM
CN1CCN(C2=Nc3cc(F)ccc3Nc3ccc(F)cc32)CC1 CHEMBL3609328 IC50 6.0 nM
O=C(N[C@H]1CN2CCC1CC2)C(O)(c1ccccc1)c1ccccc1 CHEMBL3401640 IC50 6.1 nM
C/C(C#Cc1cccs1)=C/CO/N=C1\CN2CCC1C2 CHEMBL351561 ED50 6.2 nM
O=C1CCc2ccccc2N1CCCN1CCC(n2c(=O)[nH]c3ccccc32)CC1 CHEMBL2059306 EC50 6.3 nM
Cc1cc(F)cnc1N1CCN(C(=O)CCCc2cccc3ncccc23)C(C)C1 CHEMBL4755122 IC50 6.3 nM
CN1[C@@H]2CC[C@H]1C[C@@H](OC(=O)[C@H](CO)c1ccccc1)C2 CHEMBL1331216 AC50 6.3 nM
CN(C)[C@@H]1CCCC[C@@H]1N(C)CC(=O)N1c2ccccc2NC(=O)c2ccccc21 CHEMBL2021478 pKi 6.31 nM
Cc1cc(F)cnc1N1CCN(C(=O)CCCc2cccc3ncccc23)[C@H](C)C1 CHEMBL4757103 pIC50 6.31 nM
CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1 CHEMBL4848683 pKi 6.457 nM
C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OCC)CC2)CC1 CHEMBL308566 Log Ki 6.486 nM
Cc1ccccc1CN1CCC(N2CCC(n3c(=O)[nH]c4ccccc43)CC2)CC1 CHEMBL522460 EC50 6.5 nM
NCCC1CCN(C(=O)[C@](O)(c2ccccc2)[C@@H]2CCC(F)(F)C2)CC1 CHEMBL410890 Ki 6.6 nM
C[N+]1(C)CCCC1c1ccc(C(c2ccccc2)C2CCCCC2)o1 CHEMBL569712 pKi 6.607 nM
CN1CCC=C(c2nsnc2OCCCCCC2CCN(CCCN3C(=O)CCc4ccccc43)CC2)C1 CHEMBL3354067 pKi 6.761 nM
CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@@H](CCCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1 CHEMBL4872608 pKi 6.761 nM
C[N+]1(C)CCC[C@@H]1[C@@H]1C[S+]([O-])[C@@](c2ccccc2)(C2CCCCC2)O1 CHEMBL539121 pKi 6.918 nM
CCNCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1 CHEMBL355874 Ki 6.98 nM
CCCCCCSc1nccnc1OC1CN2CCC1C2 CHEMBL54002 Ki 7.0 nM
N=C(N)NCCCCCCCCC(=O)C(N)CCCNC(=N)N CHEMBL477542 IC50 7.0 nM
Cc1cc2c(cc1Cc1ccc(-c3cscn3)cc1)C(=O)N([C@H]1CCOC[C@@H]1O)CC2 CHEMBL4093295 EC50 7.0 nM
CCC(=O)NC1CN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)C1 CHEMBL4079233 pKi 7.079 nM
CC(=O)NC(=O)[C@H](CCNC(=N)N)NC(=O)[C@@H]1CC(=O)NCCC[C@@H](C(=O)NCCN2CCN(CCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)CC2)N1 CHEMBL4852646 pKi 7.079 nM
CN1CCC[C@@H]1CCO[C@](C)(c1ccccc1)c1ccc(Cl)cc1 CHEMBL1626 AC50 7.1 nM
CN1CCC=C(c2nsnc2SCCCCCCCSc2nsnc2C2=CCCN(C)C2)C1 CHEMBL140985 Ki 7.6 nM
Fc1cc(F)cc(C#CCSc2nsnc2C23CN4CC2C3C4)c1 CHEMBL64029 EC50 7.6 nM
c1ccc2c(c1)CCc1ccccc1N2C1CN2CCC1CC2 CHEMBL107360 AC50 7.6 nM
CCN(CC)CCOC(=O)C(c1ccccc1)C1(O)CCCCC1 CHEMBL2377269 Ki 7.75 nM
N=C(N)NCCC[C@@H](NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1)C(=O)O CHEMBL4858398 pKi 7.762 nM
CCN(CC)CCOC(=O)C(c1ccccc1)C1CCCCC1 CHEMBL442444 AC50 7.8 nM
CN1[C@@H]2CC[C@H]1C[C@@H](NC(c1ccc(F)cc1)c1ccc(F)cc1)C2 CHEMBL3350391 Ki 7.81 nM
CC(=O)OC(C)C[N+](C)(C)C CHEMBL978 AC50 7.9 nM
CCCCCCCCCCCCCCCC[n+]1ccccc1 CHEMBL334255 Ki 7.941 nM
C[C@H]1CN(Cc2cccc(-c3cc(CNC(=O)c4cccc(C#N)c4)ccc3F)c2)CCN1 CHEMBL493465 pA2 7.943 nM
CO[C@H]1CC[C@](C)(N2CCC(n3c(=O)oc4ccc(C)cc43)CC2)CC1 CHEMBL1223806 pEC50 7.943 nM
N#Cc1ccc(N2CC3CCC(C2)N3C(=O)CCS(=O)(=O)c2cccc3ncsc23)nc1 CHEMBL4784357 pIC50 7.943 nM
CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1 CHEMBL4059733 pKi 7.943 nM
CC(c1ccc(S(=O)(=O)c2ccc(Cl)cc2)cc1)N1CCN(C2CCCCC2)CC1 CHEMBL75448 Ki 8.0 nM
Cc1ccc(Cc2cc3c(=O)n([C@H]4CCCC[C@@H]4O)cnc3c3ccccc23)cn1 CHEMBL4078588 Ki 8.0 nM
CC(=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)N[C@H](CCCN)C(=O)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1 CHEMBL4852868 pKi 8.128 nM
O=C(O[C@H]1CN2CCC1CC2)N(Cc1ccccc1)c1ccc(F)cc1 CHEMBL1779043 IC50 8.3 nM
CC[N+](CC)(CC)CCC(O)(c1ccccc1)C1CCCCC1 CHEMBL1201354 AC50 8.3 nM
CC[N+]1(CCOC(=O)C(O)(c2ccccc2)c2ccccc2)CCCCC1 CHEMBL1909073 Ki 8.387 nM
COc1ccc(C#C/C(C)=C\CO/N=C2\CN3CCC2C3)cc1 CHEMBL350223 ED50 8.5 nM
COc1cccc(CN2CCC(NC(=O)C(O)(c3ccccc3)C3CCCC3)CC2)c1 CHEMBL148450 Ki 8.5 nM
COc1ccc(C#C/C(C)=C\CO/N=C2/CN3CCC2C3)cc1 CHEMBL157197 ED50 8.6 nM
Cc1ccc(O)c([C@H](CCN(C(C)C)C(C)C)c2ccccc2)c1 CHEMBL1200871 Ki 8.689 nM
CCN1CCC(c2ccccc2)=C(C(=O)OCCc2ccc(C)cc2)C1 CHEMBL120119 IC50 8.8 nM
O=C(CCC1=[N+]2C(=Cc3ccc(-c4cccs4)n3[B-]2(F)F)C=C1)NCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1 CHEMBL2368393 Ki 8.8 nM
O=C(O[C@H]1CN2CCC1CC2)N(Cc1ccccc1)Cc1cccs1 CHEMBL1779039 IC50 8.8 nM
O=C(CCC1=[N+]2C(C=C1)Cc1ccc(-c3cccs3)n1[B-]2(F)F)NCCCCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1 CHEMBL2172285 Ki 8.8 nM
CCN1CCC(c2ccccc2)=C(C(=O)OCCc2ccc(C)cc2)C1 CHEMBL1180285 IC50 8.8 nM
c1ccc(C2(c3ccccc3)COC[C@H](CO[C@H]3CN4CCC3CC4)O2)cc1 CHEMBL4129580 pKi 8.913 nM
O=C(CCC1=[N+]2C(=Cc3ccc(-c4cccs4)n3[B-]2(F)F)C=C1)NCCOCCOCCOCCOCCOCCOCCCN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1 CHEMBL4645678 pKi 8.913 nM
O=C(CN1CCN(Cc2ccc(F)cc2)CC1)C(O)(c1ccccc1)C1CCCCC1 CHEMBL156542 Kb 9.0 nM
O=C(CN1CCN(Cc2ccccc2)CC1)C(O)(c1ccccc1)C1CC1 CHEMBL345605 Kb 9.0 nM
O=C(NC1CCN(Cc2ccsc2)CC1)C(O)(c1ccccc1)C1CCCC1 CHEMBL358193 Ki 9.0 nM
CCCCCCCOc1nsnc1C1=CCCN(C)C1 CHEMBL327289 IC50 9.0 nM
Clc1cccc(C#CCSc2nsnc2C23CN4CC2C3C4)c1 CHEMBL303360 EC50 9.0 nM
CCC(=O)NC1CCN(CCCN2C(=O)CCc3cc(F)ccc32)CC1 CHEMBL1243357 EC50 9.0 nM
Cc1ccnc2c(C(=O)N[C@H]3CCOC[C@@H]3O)cn(Cc3ccc(-c4ccn(C)n4)cc3)c12 CHEMBL3746869 EC50 9.0 nM
C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCNCC2)CC1 CHEMBL420008 Log Ki 9.099 nM
CNC(=O)c1ccc(Cn2cc(C(=O)N[C@H]3COCC[C@@H]3O)c3ncccc32)cc1 CHEMBL3608422 EC50 9.1 nM
C[N+]1(C)CCC[C@H]1c1ccc([C@](O)(c2ccccc2)C2CCCCC2)o1 CHEMBL568870 pKi 9.12 nM
CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1 CHEMBL4863285 pKi 9.12 nM
C[N+]12CCC(CC1)[C@@H](OC(=O)N(Cc1cccs1)c1ccccc1)C2 CHEMBL1779130 IC50 9.2 nM
CN1[C@@H]2CC[C@H]1C[C@@H](NC(c1ccccc1)c1ccc(Cl)cc1)C2 CHEMBL3085025 Ki 9.3 nM
C[N+](C)(C)C[C@@H]1COC[C@@](c2ccccc2)(C2CCCCC2)O1 CHEMBL4648229 pKi 9.333 nM
C1=C(c2cc3ccccc3o2)C2CCN1CC2 CHEMBL109405 Ki 9.6 nM
CCN1CCC(c2ccccc2)=C(C(=O)OCCc2ccccc2)C1 CHEMBL262198 IC50 9.6 nM
CN1C2CCC1CC(OC(c1ccc(F)cc1)c1ccc(F)cc1)C2 CHEMBL543113 Ki 9.74 nM
C[N+](C)(C)C[C@@H]1CO[C@@](c2ccccc2)(C2CCCCC2)CO1 CHEMBL4635385 pKi 9.772 nM
C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCN(C(=O)OCCCC)CC2)CC1 CHEMBL72408 Log Ki 9.795 nM
O=C(N[C@H]1CN2CCC1CC2)C1(O)c2ccccc2-c2ccccc21 CHEMBL3401645 IC50 9.8 nM
Cn1cc(-c2ccc(Cn3cc(C(=O)N[C@H]4CCCC[C@@H]4O)c4ncccc43)c(F)c2)cn1 CHEMBL3608413 EC50 9.8 nM