C[N+]1(C)[C@@H]2C[C@@H](OC(=O)C(O)(c3cccs3)c3cccs3)C[C@H]1[C@@H]1O[C@@H]12 CHEMBL3545181 Ki 0.0078 nM
CCCCCNC(=O)/N=C(\N)NCCCc1sc(N)nc1C CHEMBL4860528 Kd 0.052 nM
CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1 CHEMBL5207281 Kd 0.052 nM
N/C(=N\C(=O)NCc1ccccc1)NCCCc1nnc(N)s1 CHEMBL5206565 Kd 0.052 nM
C[C@@H](NC(=O)/N=C(\N)NCCCc1ncn[nH]1)c1ccccc1 CHEMBL5201074 Kd 0.052 nM
COc1ccc([S+]([O-])c2ccc(C(C)C3CCN(C4CCCCC4)CC3)cc2)cc1 CHEMBL71124 Ki 0.07 nM
C=C(c1ccc([S@@+]([O-])c2ccc(OC)cc2)cc1)C1CCN(C2CCCCC2)CC1 CHEMBL2114068 Ki 0.09 nM
C[N+]1(C)[C@@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@H]1[C@@H]1O[C@@H]12 CHEMBL1354199 Ki 0.098 nM
CN1[C@@H]2CC[C@H]1C[C@@H](OC(=O)C(CO)c1ccccc1)C2 CHEMBL517712 Ki 0.104 nM
CC(C)(CCC(C(N)=O)(c1ccccc1)c1ccccc1)N1CC(Oc2cccc(O)c2)C1 CHEMBL1910856 Ki 0.115 nM
C[N+]1(C)[C@@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@H]1[C@@H]1O[C@@H]12 CHEMBL376897 Log Ki 0.1413 nM
C[N+]1(C)CCC(OC(=O)C(O)(c2ccccc2)C2CCCC2)C1 CHEMBL1201027 pIC50 0.1585 nM
O=C(O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2)C(O)(c1cccs1)c1cccs1 CHEMBL551466 pIC50 0.1995 nM
CCN(CC)CC#CCOC(=O)C(O)(c1ccccc1)C1CCCCC1 CHEMBL1231 Ki 0.278 nM
C=C(c1ccc([S@+]([O-])c2ccc(OC)cc2)cc1)C1CCN(C2CCCCC2)CC1 CHEMBL2115128 Ki 0.32 nM
C=C(c1ccc(S(=O)(=O)c2ccc(OC)cc2)cc1)C1CCN(C2CCCCC2)CC1 CHEMBL71147 Ki 0.33 nM
CN1[C@@H]2CC[C@H]1C[C@@H](OC(c1ccccc1)c1ccccc1)C2 CHEMBL1201203 Ki 0.333 nM
O=c1ccc2c([C@@H](O)CNCCc3ccc(CCN4CCC(Cn5cnc([C@](O)(c6ccccc6)C6CCCCC6)n5)CC4)cc3)ccc(O)c2[nH]1 CHEMBL3629360 Ki 0.35 nM
C[N+]1(C)CCC(OC(=O)C(c2ccccc2)c2ccccc2)CC1 CHEMBL76897 Ki 0.37 nM
CC(C)[N+]1(C)C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2 CHEMBL1908368 Ki 0.382 nM
C[N+](C)(C)CCOC(N)=O CHEMBL14 IC50 0.4 nM
CCN(CC)CCOC(=O)C1(C2CCCCC2)CCCCC1 CHEMBL1123 Ki 0.411 nM
O=C(CCCCCNC(=O)COc1ccc(/C=C/C2=[N+]3C(=Cc4ccc(-c5cccs5)n4[B-]3(F)F)C=C2)cc1)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1 CHEMBL4742721 pKi 0.4169 nM
[2H]C([2H])(C1CCOCC1)N1C[C@H]2C[C@H](Nc3ccc(-c4cc(F)ccc4Cl)nn3)C[C@H]2C1 CHEMBL4861863 pIC50 0.4266 nM
Cn1cc2cc(-c3ccc(N[C@H]4C[C@@H]5CN(CC6CCOCC6)C[C@@H]5C4)nn3)ccc2n1 CHEMBL4853244 IC50 0.44 nM
NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1 CHEMBL4636083 pKi 0.4467 nM
C[N+]1(C)CCC[C@H]1[C@H]1CSC(c2ccccc2)(c2ccccc2)O1 CHEMBL375969 Log Ki 0.4677 nM
CCC(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1 CHEMBL4097258 pKi 0.4677 nM
CN1/C(=C/C=C/C=C/C2=[N+](CCCCCC(=O)NCCCCCCCCN3CCC(COC(=O)Nc4ccc(F)cc4-c4ccc(F)c(Cl)c4)CC3)c3ccccc3C2(C)C)C(C)(C)c2ccccc21 CHEMBL5289601 Ki 0.56 nM
CN1[C@@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@H]1[C@@H]1O[C@H]12 CHEMBL1187846 pIC50 0.5754 nM
Fc1ccc(Cl)c(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)c1 CHEMBL4873386 pIC50 0.5888 nM
CN1CCC=C(c2nsnc2SCCCCCCCCCCSc2nsnc2C2=CCCN(C)C2)C1 CHEMBL143434 EC50 0.6 nM
CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1 CHEMBL4851514 pKi 0.6607 nM
[3H]CC([3H])C(=O)NCc1cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)cc(C(=O)NCCNC(=O)CCc2cn(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)cn2)c1 CHEMBL4089543 Kd 0.67 nM
C[N+](C)(C)C[C@H]1COC[C@@](c2ccccc2)(C2CCCCC2)O1 CHEMBL4645580 pKi 0.6761 nM
C[N+]1(C)CCC[C@@H]1[C@@H]1CS[C@@](c2ccccc2)(C2CCCCC2)O1 CHEMBL222259 Log Ki 0.7079 nM
CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1 CHEMBL4862735 pKi 0.7244 nM
CN(C)CCC=C1c2ccccc2CCc2ccccc21 CHEMBL629 Ki 0.739 nM
CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1 CHEMBL4847898 pKi 0.7413 nM
OC(CCN1CCCCC1)(c1ccccc1)C1CCCCC1 CHEMBL1490 Ki 0.764 nM
CN1CCC=C(c2nsnc2OCCCCCCCCCOc2nsnc2C2=CCCN(C)C2)C1 CHEMBL143469 pKi 0.7762 nM
N=C(N)NCCC[C@H](N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1 CHEMBL4864727 pKi 0.7943 nM
CN(C)C[C@H]1COC[C@@](c2ccccc2)(C2CCCCC2)O1 CHEMBL4635500 pKi 0.8128 nM
CN1/C(=C/C=C/C=C/C2=[N+](CCCCCC(=O)NCCCCCCCCN3CCC(OC(=O)Nc4ccc(F)cc4-c4ccc(F)c(Cl)c4)CC3)c3ccccc3C2(C)C)C(C)(C)c2ccccc21 CHEMBL5289667 Ki 0.86 nM
CC1(C)C(/C=C/C=C/C=C2/N(CCCCS(=O)(=O)O)c3ccccc3C2(C)C)=[N+](CCCCCC(=O)NCCCCCCCCN2CCC(OC(=O)Nc3ccc(F)cc3-c3ccc(F)c(Cl)c3)CC2)c2ccc(S(=O)(=O)[O-])cc21 CHEMBL5271406 Ki 0.87 nM
C[N+]1(C)CCC[C@H]1[C@H]1CS[C@](c2ccccc2)(C2CCCCC2)O1 CHEMBL376057 Log Ki 0.871 nM
C[N+]1(C)CCC[C@H]1[C@H]1CS[C@@](c2ccccc2)(C2CCCCC2)O1 CHEMBL219786 Log Ki 0.871 nM
CN1CCC=C(c2nsnc2OCCCCCCCC2CCN(CCCN3C(=O)CCc4ccccc43)CC2)C1 CHEMBL3354068 pKi 0.8913 nM
CN1/C(=C/C=C/C=C/C2=[N+](CCCCCC(=O)NCCCCCCN3CCC(COC(=O)Nc4ccc(F)cc4-c4ccc(F)c(Cl)c4)CC3)c3ccccc3C2(C)C)C(C)(C)c2ccccc21 CHEMBL5273907 Ki 0.9 nM
CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1 CHEMBL4451383 pKi 0.912 nM
C[N+](C)(C)CC1COCC(c2ccccc2)(C2CCCCC2)O1 CHEMBL4634230 pKi 0.9333 nM
CN(C)c1ccc2c(-c3ccc(C(=O)NCCN4CCN(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)CC4)cc3C(=O)[O-])c3ccc(=[N+](C)C)cc-3oc2c1 CHEMBL4756833 pKi 0.9772 nM
CN1CCC=C(c2nsnc2SCCCCCCCCCCCCSc2nsnc2C2=CCCN(C)C2)C1 CHEMBL139603 EC50 1.0 nM
CCCCc1[nH]c2ccc3c(c2c1C(=O)OCC)CN1CCc2cc(OC)ccc2C1O3 CHEMBL326450 Log Ki 1.0 nM
CCCc1[nH]c2ccc3c(c2c1C(=O)OCC)CN1CCc2cc(SC)ccc2C1O3 CHEMBL104693 Log Ki 1.0 nM
CN1CCC[C@@H]1[C@@H]1CS[C@](c2ccccc2)(C2CCCCC2)O1 CHEMBL376870 Log Ki 1.0 nM
CC(CN1c2ccccc2Sc2ccccc21)N(C)C CHEMBL643 Ki 1.057 nM
CN1CCC=C(c2nsnc2OCCCCCCCCCC2CCN(CCCN3C(=O)CCc4ccccc43)CC2)C1 CHEMBL3354069 pKi 1.072 nM
CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1 CHEMBL4454300 pKi 1.072 nM
CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1 CHEMBL4569639 pKi 1.122 nM
CN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1 CHEMBL9967 pIC50 1.148 nM
CN1CCC[C@H]1[C@H]1CS[C@](c2ccccc2)(C2CCCCC2)O1 CHEMBL376255 Log Ki 1.202 nM
CC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1 CHEMBL4568151 pKi 1.202 nM
CN1CCC[C@@H]1[C@@H]1CS[C@@](c2ccccc2)(C2CCCCC2)O1 CHEMBL219825 Log Ki 1.259 nM
CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1 CHEMBL4554682 pKi 1.259 nM
CN1[C@@H]2C[C@@H](OC(=O)[C@H](CO)c3ccccc3)C[C@H]1[C@@H]1O[C@@H]12 CHEMBL569713 pIC50 1.288 nM
CC(C)[N+]1(C)[C@@H]2CC[C@H]1C[C@@H](OC(=O)C(CO)c1ccccc1)C2 CHEMBL1621597 AC50 1.3 nM
CN1CCC=C(c2nsnc2OCCCCCCCCCCCCOc2nsnc2C2=CCCN(C)C2)C1 CHEMBL142538 EC50 1.4 nM
CN(C)c1ccc2c(-c3ccc(-c4cn(CCCCCn5cc(CCCCCCN6CCC(COC(=O)Nc7ccc(F)cc7-c7ccc(F)c(Cl)c7)CC6)nn5)nn4)cc3C(=O)[O-])c3ccc(=[N+](C)C)cc-3oc2c1 CHEMBL5285607 Ki 1.4 nM
O=C(O[C@H]1C[C@H]2CC[C@@H](C1)[N+]21CCCC1)C(O)(c1ccccc1)c1ccccc1 CHEMBL3084748 pKi 1.445 nM
CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1 CHEMBL4864987 pKi 1.445 nM
CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1 CHEMBL4855492 pKi 1.445 nM
C[N+](C)(C)C[C@H]1COCC(c2ccccc2)(c2ccccc2)O1 CHEMBL2042405 pKi 1.479 nM
CCN(CC)CCOC(=O)C(O)(c1cccs1)C1CCCCC1 CHEMBL2377267 Ki 1.49 nM
O=C1CCCN1CC#CCN1CCCC1 CHEMBL7634 Ki 1.5 nM
CN(C)CCCOC(=O)C(C)(c1ccccc1)C1CCCCC1 CHEMBL286008 Ki 1.5 nM
CC(=O)Nc1ccc(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)cc1 CHEMBL4855467 IC50 1.5 nM
CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1 CHEMBL4589047 pKi 1.622 nM
Fc1ccc(F)c(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)c1 CHEMBL4864914 pIC50 1.66 nM
CN1/C(=C/C=C/C=C/C2=[N+](CCCCCC(=O)NCCCNCCCCCCN3CCC(COC(=O)Nc4ccc(F)cc4-c4ccc(F)c(Cl)c4)CC3)c3ccccc3C2(C)C)C(C)(C)c2ccccc21 CHEMBL5289083 Ki 1.7 nM
COc1ccc(F)cc1C1CCN([C@@H]2CCC3(C2)CN(C(=O)C2COC2)C3)CC1 CHEMBL5399732 EC50 1.7 nM
Fc1ccccc1-c1ccc(N[C@H]2C[C@@H]3CN(CC4CCOCC4)C[C@@H]3C2)nn1 CHEMBL4851711 pIC50 1.738 nM
Fc1ccc(Cl)c(-c2ccc(NC[C@@H]3CC34CCN(CC3CCOCC3)CC4)nn2)c1 CHEMBL5182783 IC50 1.8 nM
C[N+]1(C)CCC[C@@H]1[C@@H]1CS[C@](c2ccccc2)(C2CCCCC2)O1 CHEMBL220393 Log Ki 1.82 nM
N=C(N)NCCC[C@@H](N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1 CHEMBL4870127 pKi 1.82 nM
CN1CCC=C(c2nsnc2OCCOCCOCCOCCOc2nsnc2C2=CCCN(C)C2)C1 CHEMBL335542 Log Ki 1.995 nM
CCCc1[nH]c2ccc3c(c2c1C(=O)OCC)CN1CCc2cc(OC)ccc2C1O3 CHEMBL320465 Log Ki 1.995 nM
CCCc1c(C(=O)OCC)c2c3c(ccc2n1C)OC1c2ccc(OC)cc2CCN1C3 CHEMBL106224 Log Ki 1.995 nM
CCCc1c(C(=O)OCC)c2c3c(ccc2n1C)OC1c2ccc(SC)cc2CCN1C3 CHEMBL280220 Log Ki 1.995 nM
CN1CCC[C@@H]1[C@@H]1CSC(c2ccccc2)(c2ccccc2)O1 CHEMBL375073 Log Ki 1.995 nM
CCN(CC)CCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1 CHEMBL295388 pKi 1.995 nM
CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1 CHEMBL4597498 pKi 1.995 nM
CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1 CHEMBL4540949 pKi 2.042 nM
N=C(N)NCCC[C@@H](NC1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1)C(=O)O CHEMBL4871700 pKi 2.042 nM
CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1 CHEMBL4582879 pKi 2.089 nM
CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21 CHEMBL4641726 pKi 2.138 nM
CN1CCC(=C2c3ccccc3C=Cc3ccccc32)CC1 CHEMBL516 Ki 2.186 nM
COc1ccc([S+]([O-])c2ccc(C(C)N3CCN(C4CCCCC4)CC3)cc2)cc1 CHEMBL307810 Ki 2.2 nM
O=C(OC1CN2CCC1CC2)N(CCc1ccc(F)cc1)c1ccccc1 CHEMBL4519301 Ki 2.2 nM
O=C(NC[C@H]1CCCN(CC2CCCCC2)C1)[C@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1 CHEMBL2112957 Ki 2.3 nM
Fc1cccc(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)c1 CHEMBL4854289 IC50 2.3 nM
O=C(N1CC2(CC[C@@H](N3CCC(c4cc(Cl)ccc4Cl)CC3)C2)C1)C1(F)CC1 CHEMBL5416536 EC50 2.3 nM
CN1CCC[C@H]1[C@H]1CS[C@@](c2ccccc2)(C2CCCCC2)O1 CHEMBL385328 Log Ki 2.344 nM
CN(C)C[C@H]1COCC(c2ccccc2)(c2ccccc2)O1 CHEMBL2042553 pKi 2.344 nM
CN(C)C[C@H]1COCC(c2ccccc2)(c2ccccc2)O1 CHEMBL2078942 pKi 2.344 nM
CN(C)CC1COCC(c2ccccc2)(C2CCCCC2)O1 CHEMBL4649224 pKi 2.399 nM
CC(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1 CHEMBL4548432 pKi 2.455 nM
COc1nsnc1OCCOCCOCCOCCOc1nsnc1C1=CCCN(C)C1 CHEMBL553058 Log Ki 2.512 nM
COc1nsnc1OCCOCCOCCOCCOc1nsnc1C1=CCCN(C)C1 CHEMBL216927 Log Ki 2.512 nM
CCC(=O)NCCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1 CHEMBL4059733 pKi 2.512 nM
NC1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1 CHEMBL4878646 pKi 2.512 nM
CN1CC=C(c2nsnc2OCCCN2CCN(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)CC2)CC1 CHEMBL4455570 pKi 2.57 nM
CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCN4CCC(N5CCC(n6c(=O)[nH]c7ccccc76)CC5)CC4)cc(C(=O)NCCN4CCN(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)CC4)c3)c3ccc(S(=O)(=O)[O-])cc3C2(C)C)=[N+](CCCCS(=O)(=O)O)c2ccccc21 CHEMBL4643273 pKi 2.57 nM
CN(C)c1ccc2c(-c3ccc(-c4cn(CCCCCn5cc(CCCCCN6CCC(COC(=O)Nc7ccc(F)cc7-c7ccc(F)c(Cl)c7)CC6)nn5)nn4)cc3C(=O)[O-])c3ccc(=[N+](C)C)cc-3oc2c1 CHEMBL5268503 Ki 2.6 nM
C[N+](C)(C)CC1COCC(c2ccccc2)(c2ccccc2)O1 CHEMBL2042404 pKi 2.63 nM
Cc1cc(/C=C/c2cc3c4c(c2)CCCN4CCC3)cc(C)[n+]1CCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1 CHEMBL4744233 pKi 2.63 nM
CCC(=O)NCc1cc(C(=O)NCCN2CCC(N3CCC(n4c(=O)[nH]c5ccccc54)CC3)CC2)cc(C(=O)NCCN2CCN(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)CC2)c1 CHEMBL4471882 pKi 2.692 nM
Cc1cc(/C=C/c2cc3c4c(c2)CCCN4CCC3)cc(C)[n+]1CCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1 CHEMBL4748004 pKi 2.692 nM
CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NC1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1 CHEMBL4861252 pKi 2.692 nM
CN1CCC[C@@H]1CCO[C@](C)(c1ccccc1)c1ccc(Cl)cc1 CHEMBL1626 Ki 2.773 nM
c1ccc(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)cc1 CHEMBL4876599 IC50 2.8 nM
CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCc3cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)c3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21 CHEMBL4636899 pKi 2.884 nM
N=C(N)NCCCCC(=O)NC1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1 CHEMBL4878717 pKi 2.884 nM
CCOC(=O)N1CCC2(CC(N3C[C@@H]4[C@H](C3)[C@@H]4c3nccn3-c3ccccc3)C2)C1 CHEMBL4583597 EC50 3.0 nM
CCCCc1[nH]c2ccc3c(c2c1C(=O)OCC)CN1CCc2cc(SC)ccc2C1O3 CHEMBL318995 Log Ki 3.02 nM
CCOC(=O)c1c(CC)n(C)c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3 CHEMBL106218 Log Ki 3.02 nM
CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1 CHEMBL4876453 pKi 3.09 nM
Cc1ccc(O)c([C@H](CCN(C(C)C)C(C)C)c2ccccc2)c1 CHEMBL1382 Ki 3.1 nM
CC(=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCNC(=N)N)N[C@@H](CCCN)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1 CHEMBL4874955 pKi 3.162 nM
CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1 CHEMBL4515788 pKi 3.236 nM
CN(C)c1ccc2c(-c3ccc(-c4cn(CCCCCn5cc(CCCCCN6CCC(OC(=O)Nc7ccc(F)cc7-c7ccc(F)c(Cl)c7)CC6)nn5)nn4)cc3C(=O)[O-])c3ccc(=[N+](C)C)cc-3oc2c1 CHEMBL5283759 Ki 3.3 nM
CN1CCC[C@H]1[C@H]1CSC(c2ccccc2)(c2ccccc2)O1 CHEMBL373515 Log Ki 3.311 nM
CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1 CHEMBL4856113 pKi 3.311 nM
C[N+]1(C)CCC[C@@H]1[C@@H]1CSC(c2ccccc2)(c2ccccc2)O1 CHEMBL375851 Log Ki 3.467 nM
CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1 CHEMBL4852186 pKi 3.467 nM
CCN(Cc1ccncc1)C(=O)C(CO)c1ccccc1 CHEMBL1200604 Ki 3.483 nM
CC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1 CHEMBL4567026 pKi 3.548 nM
CCC(=O)NC1CN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)C1 CHEMBL4079233 pKi 3.631 nM
CCC(C)C(C(=O)OCC[N+](C)(CC)CC)c1ccccc1 CHEMBL2107687 Ki 3.669 nM
CN(C)c1ccc2c(-c3ccc(C(=O)NCCNC(=O)CCc4cn(CCCCC5CCN(CC(=O)N6c7ccccc7NC(=O)c7ccccc76)CC5)cn4)cc3C(=O)[O-])c3ccc(=[N+](C)C)cc-3oc2c1 CHEMBL4789147 pKi 3.715 nM
CN(C)c1ccc2c(-c3ccc(-c4cn(CCCCCn5cc(CCCCCCN6CCC(OC(=O)Nc7ccc(F)cc7-c7ccc(F)c(Cl)c7)CC6)nn5)nn4)cc3C(=O)[O-])c3ccc(=[N+](C)C)cc-3oc2c1 CHEMBL5267836 Ki 3.8 nM
C[C@H](NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1)C(=O)NC(=O)[C@@H](N)CCCN CHEMBL4859378 pKi 3.802 nM
CC(=O)NC(=O)[C@H](CCNC(=N)N)NC(=O)[C@@H]1CC(=O)NCCC[C@@H](C(=O)NCCN2CCN(CCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)CC2)N1 CHEMBL4876725 pKi 3.89 nM
CCOC(=O)c1c(CC)[nH]c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3 CHEMBL105148 Log Ki 3.981 nM
CN1CCC[C@@H]1c1ccc([C@](O)(c2ccccc2)C2CCCCC2)o1 CHEMBL571121 pKi 3.981 nM
CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21 CHEMBL4641714 pKi 3.981 nM
N=C(N)NCCC[C@@H](N)C(=O)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1 CHEMBL4850130 pKi 3.981 nM
CC(=O)OC1CC2CCCC1N2 CHEMBL64000 Ki 4.0 nM
CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1 CHEMBL4871153 pKi 4.074 nM
Fc1cc(F)c(F)c(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)c1 CHEMBL4850236 pIC50 4.074 nM
C[N+]1(C)CCC[C@@H]1c1ccc([C@](O)(c2ccccc2)C2CCCCC2)o1 CHEMBL569307 pKi 4.266 nM
Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCNC(=O)CCc1cn(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)cn1 CHEMBL4754371 pKi 4.266 nM
N=C(N)NCCC[C@@H](NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1)C(=O)O CHEMBL4858398 pKi 4.266 nM
C[N+]1(C)C2CCC1CC1(C2)OC(=O)C(c2ccccc2)(c2ccccc2)O1 CHEMBL292857 Log Ki 4.365 nM
CC(=O)NC(=O)[C@H](CCNC(=N)N)NC(=O)[C@@H]1CC(=O)NCCC[C@@H](C(=O)NCCN2CCN(CCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)CC2)N1 CHEMBL4852646 pKi 4.365 nM
CC1(C)C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCNC(=O)CCc3cn(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)cn3)c3ccc(S(=O)(=O)O)cc3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccccc21 CHEMBL4644612 pKi 4.467 nM
[2H]C([2H])(C1CCOCC1)N1C[C@H]2C[C@H](Nc3ccc(-c4cc(F)cc(F)c4F)nn3)C[C@H]2C1 CHEMBL4873617 pIC50 4.467 nM
CCN(CC)CCCOC(=O)C(C)(c1ccccc1)C1CCCCC1 CHEMBL284137 Ki 4.6 nM
CN1CCC=C(c2nsnc2SCCCCCCCCCCCSc2nsnc2C2=CCCN(C)C2)C1 CHEMBL143466 EC50 4.7 nM
C[N+]12CCC(CC1)C(OC(=O)C(O)(c1ccccc1)c1ccccc1)C2 CHEMBL620 AC50 4.7 nM
CN(C)CC1COCC(c2ccccc2)(c2ccccc2)O1 CHEMBL2042552 pKi 4.898 nM
c1cncc(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)c1 CHEMBL4848896 IC50 5.2 nM
CN1/C(=C/C=C/C=C/C2=[N+](CCCCCC(=O)NCCCCCCN3CCC(OC(=O)Nc4ccc(F)cc4-c4ccc(F)c(Cl)c4)CC3)c3ccccc3C2(C)C)C(C)(C)c2ccccc21 CHEMBL5277670 Ki 5.4 nM
CO/N=C(\C#N)[C@H]1CN2CCC1CC2 CHEMBL134641 EC50 5.7 nM
CN(C)CCC=C1c2ccccc2COc2ccccc21 CHEMBL1628227 Ki 5.842 nM
CCCCCCOc1nsnc1C1=CCCN(C)C1 CHEMBL21536 EC50 6.0 nM
C[N+](C)(C)C[C@@H]1CS[C@@](c2ccccc2)(C2CCCCC2)O1 CHEMBL45454 Log Ki 6.166 nM
COc1ccccc1C1CCN(C2CCC3(C2)CN(C(=O)C2COC2)C3)CC1 CHEMBL5401679 EC50 6.2 nM
CC(C)N(CC[C@H](c1ccccc1)c1cc(CCNC(=O)CCCCCNC(=O)COc2ccc(/C=C/C3=[N+]4C(=Cc5ccc(-c6cccs6)n5[B-]4(F)F)C=C3)cc2)ccc1O)C(C)C CHEMBL271108 Ki 6.3 nM
CN1CCN(C2=Nc3cc(Cl)ccc3Nc3ccccc32)CC1 CHEMBL42 Ki 6.303 nM
CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CCCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc21 CHEMBL265256 Log Ki 6.457 nM
CCOC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3 CHEMBL59898 Log Ki 6.457 nM
CCN(CC)CCCCC1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1 CHEMBL43383 pKi 6.457 nM
CN(CCCCCCCCN(C)CCCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CC(=O)N1c2ccccc2C(=O)Nc2cccnc21)CCCCCCNCC(=O)N1c2ncccc2NC(=O)c2cccnc21 CHEMBL4448108 pKi 6.457 nM
N#Cc1ccc(N2C3CCC2CN(C(=O)CCS(=O)(=O)c2cccc4ncsc24)C3)nc1 CHEMBL4790083 Ki 6.5 nM
CCOc1ccccc1C1CCN([C@@H]2CCC3(C2)CN(C(=O)C2COC2)C3)CC1 CHEMBL5419462 EC50 6.5 nM
CN1CCC=C(c2nsnc2OCCCCCCCCCCCC2CCN(CCCN3C(=O)CCc4ccccc43)CC2)C1 CHEMBL3354070 pKi 6.607 nM
OC(CCN1CCCCC1)(c1ccccc1)C1CCCCC1 CHEMBL1092 IC50 6.7 nM
c1ccc(-n2ccnc2[C@@H]2[C@@H]3CN(C4CC5(CCN(c6cnccn6)C5)C4)C[C@@H]32)cc1 CHEMBL4515088 EC50 7.0 nM
CCOC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2cc(SC)ccc2C1O3 CHEMBL105122 Log Ki 7.079 nM
CCN(CC)CCSC(=O)C(O)(c1ccccc1)c1ccccc1 CHEMBL2377387 Ki 7.23 nM
CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccccc1 CHEMBL26505 Ki 7.4 nM
CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1 CHEMBL4863285 pKi 7.586 nM
CC(=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)N[C@H](CCCN)C(=O)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1 CHEMBL4852868 pKi 7.762 nM
CN1Cc2cc(-c3ccc(N[C@H]4C[C@@H]5CN(CC6CCOCC6)C[C@@H]5C4)nn3)ccc2C1=O CHEMBL4865665 pIC50 7.762 nM
Fc1ccc(-c2ccc(N[C@H]3C[C@@H]4CN(CC5CCOCC5)C[C@@H]4C3)nn2)cc1 CHEMBL4860985 pIC50 7.762 nM
Cc1noc(C)c1S(=O)(=O)N1CCN(c2ccc(N3CCCC(C)(C)C3)nn2)CC1 CHEMBL4071900 Ki 7.78 nM
CN1CCC=C(c2nsnc2OCCCCCC2CCN(CCCN3C(=O)CCc4ccccc43)CC2)C1 CHEMBL3354067 pKi 7.943 nM
Cc1nnc2sc(C(=O)NC3CN(c4ccncc4Cl)C3)c(N)c2c1C CHEMBL4066508 EC50 8.0 nM
Cc1c(Cl)c2nnc(C)n2c2sc(C(=O)NC3Cc4ccccc4C3)c(N)c12 CHEMBL4579086 EC50 8.0 nM
CC[N+]1(CCOC(=O)C(O)(c2ccccc2)c2ccccc2)CCCCC1 CHEMBL1909073 Ki 8.584 nM
NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(CCc2ccc3c(c2)CCO3)C1 CHEMBL1346 Ki 8.6 nM
C[C@@H]1OC(=O)[C@H]2C[C@H]3CCCC[C@@H]3[C@@H](/C=C/[C@H]3CCC[C@H](C)N3C)[C@@H]12 CHEMBL277642 Log Ki 8.71 nM
CCOC(=O)N1CCC2(CC(N3CCC(c4ncccc4OC)CC3)C2)C1 CHEMBL4543638 EC50 9.0 nM
COc1ccc(S(=O)(=O)c2ccc(C(=O)C3CCN(C4CCCCC4)CC3)cc2)cc1 CHEMBL71531 Ki 9.05 nM
NC(=O)OCCN1CCC(N2CCC(n3c(=O)[nH]c4ccccc43)CC2)CC1 CHEMBL485913 EC50 9.1 nM
CCOC(=O)N1CCC(N2CCC(n3c(=O)[nH]c4ccccc43)CC2)CC1 CHEMBL491209 EC50 9.1 nM
COc1cc(F)ccc1C1CCN([C@@H]2CCC3(C2)CN(C(=O)C2COC2)C3)CC1 CHEMBL5436967 EC50 9.3 nM
CCN(CC)CCOC(=O)C(c1ccccc1)C1(O)CCCCC1 CHEMBL2377269 Ki 9.48 nM
Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1 CHEMBL4646116 pKi 9.55 nM
Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCN1CCN(CCCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1 CHEMBL4650998 pKi 9.55 nM
CCCN(CCC)CC1CCCCN1CCNC(=O)N1c2ccccc2C(=O)Nc2cccnc21 CHEMBL279453 Log Ki 10.0 nM
Cc1c(NC2CC2)nc(C2CC2)nc1N1CCCCCC1 CHEMBL205654 Log Ki 10.0 nM
N=C(N)NCCCCCCCCC(=O)C(N)CCCNC(=N)N CHEMBL477542 IC50 10.0 nM
CC(=O)OCC[N+](C)(C)C CHEMBL667 EC50 10.0 nM
Cc1c(Cl)nnc2sc(C(=O)NC3Cc4ccccc4C3)c(N)c12 CHEMBL4783881 EC50 10.0 nM
COc1cc(N2CC(NC(=O)c3sc4nnc(Cl)c(C)c4c3N)C2)c(Cl)cn1 CHEMBL4798497 EC50 10.0 nM
O=C(C1CCN(c2cc(Oc3ccc(F)cc3F)ncn2)CC1)N1CCc2ccccc2C1 CHEMBL4059829 Ki 10.3 nM
CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@@H](CCCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1 CHEMBL4872608 pKi 10.47 nM
Cc1nnc2sc(C(=O)NC3CN(c4cc(F)nc(F)c4)C3)c(N)c2c1C CHEMBL4088704 pEC50 10.72 nM
CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1 CHEMBL4562770 pKi 10.72 nM
CCCCCc1[nH]c2ccc3c(c2c1C(=O)OCC)CN1CCc2cc(OC)ccc2C1O3 CHEMBL104210 Log Ki 10.96 nM
CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1 CHEMBL4862996 pKi 10.96 nM
O=C(CCNC(=O)[C@@H]1CCCN1C(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1)NC[C@H]1CCCN(CC2CCCCC2)C1 CHEMBL2112958 Ki 11.0 nM
O=C(NCC1CCN(CC2CCCC2)CC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1 CHEMBL214898 Ki 11.0 nM
CSc1ccc2c(c1)N(CCC1CCCCN1C)c1ccccc1S2 CHEMBL479 Ki 11.0 nM
CCOC(=O)N1CCCC(N2CCC(c3ncccc3OC)CC2)CC1 CHEMBL4461438 EC50 11.0 nM
C[N+]1(C)CCC2(CC1)OC(=O)C(c1ccccc1)(c1ccccc1)O2 CHEMBL306182 Log Ki 11.22 nM
c1ccc(C2(c3ccccc3)COC[C@H](CO[C@@H]3CN4CCC3CC4)O2)cc1 CHEMBL4128341 pKi 11.48 nM
Fc1ccc(Cl)c(-c2ccc(NC[C@@H]3CC34CCN(CC3CCCCC3)CC4)nn2)c1 CHEMBL5205163 pIC50 11.75 nM
Cc1c(Cl)c2nncn2c2sc(C(=O)NC3Cc4ccccc4C3)c(N)c12 CHEMBL4475459 EC50 12.0 nM
Cc1cc2nncn2c2sc(C(=O)NC3CN(c4ccc(F)c(F)c4)C3)c(N)c12 CHEMBL4459622 EC50 12.0 nM
CN(C)[C@@H]1CCCC[C@@H]1N(C)CC(=O)N1c2ccccc2NC(=O)c2ccccc21 CHEMBL2021478 pKi 12.3 nM
CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1 CHEMBL4856659 pKi 12.3 nM
COc1nsnc1OCCOCCOCCOCCOCCOc1nsnc1C1=CCCN(C)C1 CHEMBL386983 Log Ki 12.59 nM
Cc1cc2c(s1)Nc1ccccc1N=C2N1CCN(C)CC1 CHEMBL715 Log Ki 12.59 nM
C[N+]1(CCCC(O)(c2ccccc2)c2ccccc2)CCC(C2CC[N+](C)(CCCC(O)(c3ccccc3)c3ccccc3)CC2)CC1 CHEMBL402207 Log Ki 12.59 nM
CCCO[C@H]1CC[C@](C)(N2CCC(n3c(=O)[nH]c4cc(F)c(C)cc43)CC2)CC1 CHEMBL1223754 pEC50 12.59 nM
COc1ccc([S@@+]([O-])c2ccc(C(C#N)C3CCN(C4CCCCC4)CC3)cc2)cc1 CHEMBL2114064 Ki 12.74 nM
CN(C)[C@@H]1CCCC[C@H]1N(C)CC(=O)N1c2ccccc2NC(=O)c2ccccc21 CHEMBL2021476 pKi 12.88 nM
CN(C)CCCN1c2ccccc2CCc2ccc(Cl)cc21 CHEMBL415 Ki 13.0 nM
CNCCC=C1c2ccccc2CCc2ccccc21 CHEMBL445 Ki 13.0 nM
CCOC(=O)N1CCC(C)(CN2CCC3(CC2)CN(S(C)(=O)=O)c2ncccc23)CC1 CHEMBL3289442 EC50 13.0 nM
CC[N+](C)(CC)CCOC(=O)C(O)(c1ccccc1)c1ccccc1 CHEMBL2106570 Ki 13.2 nM
CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1 CHEMBL4854886 pKi 13.49 nM
O=C(CCNC(=O)CNC(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1)NC[C@H]1CCCN(CC2CCCCC2)C1 CHEMBL2112955 Ki 14.0 nM
CN1[C@@H]2CC[C@H]1C[C@@H](OC(=O)C(O)c1ccccc1)C2 CHEMBL1319362 Ki 14.0 nM
Cc1cc2c(nc1N1CCC(Oc3ccc4[nH]ncc4c3)CC1)CNC2=O CHEMBL4202966 EC50 14.0 nM
Cc1cc2c(nc1N1CCC(Oc3cccc(C#N)c3)CC1)COC2=O CHEMBL4215436 EC50 14.0 nM
CCOc1ccccc1C1CCN([C@@H]2CCC3(C2)CN(C(=O)CC)C3)CC1 CHEMBL5440079 EC50 14.0 nM
CCCCCCc1[nH]c2ccc3c(c2c1C(=O)OCC)CN1CCc2cc(OC)ccc2C1O3 CHEMBL105160 Log Ki 14.13 nM
CN1CCCC1c1ccc(C(O)(c2ccccc2)C2CCCCC2)o1 CHEMBL583051 pKi 14.13 nM
CN1CCC=C(c2nsnc2OCCCCCCCCCCCCCC2CCN(CCCN3C(=O)CCc4ccccc43)CC2)C1 CHEMBL3354071 pKi 14.45 nM
COc1ccc([S@@+]([O-])c2ccc(C(C#N)N3CCN(C4CCCCC4)CC3)cc2)cc1 CHEMBL2111540 Ki 14.8 nM
CCCCCCCCCCCCCCCC[n+]1ccccc1 CHEMBL334255 Ki 15.0 nM
CCOC(=O)N1CCC(C)(CN2CC[C@H](N3C(=O)Cc4ccccc43)C2)CC1 CHEMBL2336056 EC50 15.0 nM
COc1ccc(OC2CCN(c3nc4oc(=O)[nH]c(=O)c4c(Cl)c3C)CC2)cn1 CHEMBL4211671 EC50 15.0 nM
C=CCOC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3 CHEMBL420662 Log Ki 15.14 nM
CCOC(=O)c1c(C)n(C)c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3 CHEMBL107444 Log Ki 15.14 nM
COc1ccc([S@+]([O-])c2ccc(C(=O)C3CCN(C4CCCCC4)CC3)cc2)cc1 CHEMBL2115127 Ki 15.2 nM
COc1ccccc1CN1CCC(C2CCN(CCCCCCCCN3CCC(C4CCN(Cc5ccccc5OC)CC4)CC3)CC2)CC1 CHEMBL127273 Ki 15.3 nM
C[N+]1(C)CCCC1c1ccc(C(O)(c2ccccc2)C2CCCCC2)o1 CHEMBL569760 pKi 15.49 nM
Cc1nnc2sc(C(=O)NC3CN(c4cncc(F)c4)C3)c(N)c2c1C CHEMBL4104144 pEC50 15.49 nM
C[N+]1(C)CCC[C@H]1[C@H]1C[S+]([O-])[C@@](c2ccccc2)(C2CCCCC2)O1 CHEMBL539120 pKi 15.85 nM
CN(C)[C@H]1CCCC[C@H]1N(C)CC(=O)N1c2ccccc2NC(=O)c2ccccc21 CHEMBL2021479 pKi 15.85 nM
CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1 CHEMBL4848683 pKi 15.85 nM
COc1cccnc1C1CCN(C2CCCN(c3cnccn3)CC2)CC1 CHEMBL4455058 EC50 16.0 nM
Cc1c(Cl)c2nncn2c2sc(C(=O)NC3CC3)c(N)c12 CHEMBL4446894 EC50 16.0 nM
Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1 CHEMBL4642045 pKi 16.22 nM
COc1ccccc1CN1CCC(C2CCN(C(=O)CCCCCCC(=O)N3CCC(C4CCN(Cc5ccccc5OC)CC4)CC3)CC2)CC1 CHEMBL130835 Ki 16.6 nM
COc1cncc(N2CC(NC(=O)c3sc4nnc(C)c(C)c4c3N)C2)c1 CHEMBL4083327 pEC50 16.98 nM
Cc1ccccc1C(OCCN(C)C)c1ccccc1 CHEMBL900 Ki 17.0 nM
Cc1cc2c(nc1N1CC[C@@H](Oc3ccc4c(cnn4C)c3)[C@@H](F)C1)CNC2=O CHEMBL4208543 EC50 17.0 nM
Cc1cc2nncn2c2sc(C(=O)NC3Cc4ccccc4C3)c(N)c12 CHEMBL4575270 EC50 17.0 nM
COc1cc2ccc(-c3nc(C)ccc3-c3cnn(CC4(F)CCCC4)c3)cc2nn1 CHEMBL5287400 IC50 17.0 nM
CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1 CHEMBL4565234 pKi 17.38 nM
COc1ccc([S@@+]([O-])c2ccc(C(=O)C3CCN(C4CCCCC4)CC3)cc2)cc1 CHEMBL2114067 Ki 17.9 nM
Cc1cc(C(=O)NCc2ccncc2)nnc1N1CCC(Oc2ccc3c(c2)OCCO3)CC1 CHEMBL4207853 EC50 18.0 nM
Cc1cc2c(=O)[nH]ncc2nc1N1CCC(OCC2(C)CC2)CC1 CHEMBL4210497 EC50 18.0 nM
COc1ccc(OC2CCN(c3nc4[nH]c(=O)[nH]c(=O)c4cc3C)CC2)cn1 CHEMBL4208024 EC50 18.0 nM
Fc1ccc(Cl)c(-c2ccc(NCC3CC34CCN(CC3CCCCC3)CC4)nn2)c1 CHEMBL5185664 IC50 18.0 nM
Cc1nnc2sc(C(=O)NC3CN(c4cccnc4F)C3)c(N)c2c1C CHEMBL4101054 pEC50 18.2 nM
COc1ccc([S@+]([O-])c2ccc(C(C#N)N3CCN(C4CCCCC4)CC3)cc2)cc1 CHEMBL2114066 Ki 18.4 nM
CCN(CC)CCOC(=O)C(C)(c1ccccc1)C1CCCCC1 CHEMBL443780 Ki 18.5 nM
COc1ccc(S(=O)(=O)c2ccc(C(C#N)N3CCN(C4CCCCC4)CC3)cc2)cc1 CHEMBL71971 Ki 18.6 nM
CN(C)[C@H]1CCCC[C@@H]1N(C)CC(=O)N1c2ccccc2NC(=O)c2ccccc21 CHEMBL2021477 pKi 18.62 nM
Cc1nnc2sc(C(=O)NC3CN(c4cccc(F)c4F)C3)c(N)c2c1C CHEMBL4062319 pEC50 18.62 nM
C[N+]1=C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCN3CCN(CCCCC4CCN(CC(=O)N5c6ccccc6NC(=O)c6ccccc65)CC4)CC3)c3ccccc3C2(C)C)C(C)(C)c2ccccc21 CHEMBL4649420 pKi 18.62 nM
NCCN1CCN(CCCC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1 CHEMBL4862087 pKi 18.62 nM
CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1 CHEMBL395110 Ki 19.0 nM
C[N+]1(C)CCC[C@@H]1[C@@H]1C[S+]([O-])[C@@](c2ccccc2)(C2CCCCC2)O1 CHEMBL539121 pKi 19.05 nM
C[N+]1(C)CCCC1c1ccc(C(c2ccccc2)C2CCCCC2)o1 CHEMBL569712 pKi 19.5 nM
COc1nsnc1OCCCCCCCCCCCCOc1nsnc1C1=CCCN(C)C1 CHEMBL136027 Log Ki 19.95 nM
O=c1[nH]c2ccccc2n1C1CCN(C2CCCCC2)CC1 CHEMBL2146597 pEC50 19.95 nM
CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1 CHEMBL4846562 pKi 19.95 nM
O=C(NCC1CCN(CC2CC2)CC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1 CHEMBL378772 Ki 20.0 nM
Cc1c(Cl)nc(CO)nc1N1CC[C@@H](Oc2ccc3[nH]ncc3c2)[C@@H](F)C1 CHEMBL4207315 EC50 20.0 nM
Cc1cc2c(nc1N1CCC(Oc3ccccc3)CC1)CN(S(C)(=O)=O)C2 CHEMBL4212205 EC50 20.0 nM
Cc1cn2c(=O)[nH]nc2nc1N1CCC(Oc2ccc3c(c2)COC3)CC1 CHEMBL4203670 EC50 20.0 nM
COc1cccnc1C1CCN(C2CCCN(c3cnsn3)CC2)CC1 CHEMBL4447724 EC50 20.0 nM
Cc1c(Cl)c2nncn2c2sc(C(=O)N[C@H]3CCc4ccccc43)c(N)c12 CHEMBL4439440 EC50 20.0 nM
Cc1nnc2sc(C(=O)NC3Cc4ccccc4C3)c(N)c2c1C CHEMBL4785432 EC50 20.0 nM
COc1nnc2sc(C(=O)NC3Cc4ccccc4C3)c(N)c2c1C CHEMBL4778766 EC50 20.0 nM
Cc1c(Cl)nnc2sc(C(=O)NC3CN(c4cccnc4)C3)c(N)c12 CHEMBL4782416 EC50 20.0 nM
Cc1c(Cl)nnc2sc(C(=O)NC3CN(c4cc(C(F)(F)F)ncc4Cl)C3)c(N)c12 CHEMBL4776981 EC50 20.0 nM
CN(C)CCCN1c2ccccc2Sc2ccc(Cl)cc21 CHEMBL71 Ki 21.0 nM
CCN(CC)CCCOC(=O)N1c2ccccc2Sc2ccccc21 CHEMBL519609 Ki 21.0 nM
COc1ccc(OC2CCN(c3nc4cn[nH]c(=O)c4cc3C)CC2)cn1 CHEMBL4212929 EC50 22.0 nM
Cc1c(Cl)c2nnc(C)n2c2sc(C(=O)NC3CC3)c(N)c12 CHEMBL4568327 EC50 22.0 nM
Cc1nnc2sc(C(=O)NC3CN(C(=O)Oc4ccccc4)C3)c(N)c2c1C CHEMBL4074908 pEC50 22.39 nM
c1ccc(C2(c3ccccc3)COC[C@H](CO[C@H]3CN4CCC3CC4)O2)cc1 CHEMBL4129580 pKi 22.91 nM
C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O CHEMBL12587 Ki 23.0 nM
CCOC(=O)N1CCC(CN2CCC(c3ncccc3OC)CC2)CC1 CHEMBL4446791 EC50 23.0 nM
CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1 CHEMBL4443219 pKi 23.44 nM
Cc1nnc2sc(C(=O)NC3CN(C(=O)OCc4ccccc4)C3)c(N)c2c1C CHEMBL4101598 pEC50 23.99 nM
O=C(NCCC1CCNCC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(Cl)cc1)(c1ccc(Cl)cc1)c1ccc(Cl)cc1 CHEMBL378859 Ki 24.0 nM
Cc1nnc2sc(C(=O)NC3CN(c4ccccc4)C3)c(N)c2c1C CHEMBL4060475 pEC50 24.55 nM
CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1 CHEMBL4857722 pKi 24.55 nM
COc1ccc(OC2CCN(c3nc(CO)nc(Cl)c3C)CC2)cn1 CHEMBL4216650 EC50 25.0 nM
COc1ccc(CCN(C(=O)OC2CN3CCC2CC3)c2ccccc2)cc1 CHEMBL4585326 Ki 25.0 nM
COc1nsc(OCCOCCOCCOCCOc2nsnc2C2C=CCCN2C)n1 CHEMBL216928 Log Ki 25.12 nM
COC(=O)C1=CCCN(C)C1 CHEMBL7303 Ki 26.0 nM
Cc1cc2nncn2c2sc(C(=O)NC3CN(c4cccc(F)c4F)C3)c(N)c12 CHEMBL4458791 EC50 26.0 nM
CN1CCC=C(c2nsnc2OCCCC2CCN(CCCN3C(=O)CCc4ccccc43)CC2)C1 CHEMBL3354066 pKi 26.3 nM
Cc1nnc2sc(C(=O)NCc3ccc(-c4ccncc4)cc3)c(N)c2c1C CHEMBL4070692 pEC50 26.92 nM
Cc1nnc2sc(C(=O)NC3CN(c4ccccc4F)C3)c(N)c2c1C CHEMBL4080834 pEC50 27.54 nM
CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1 CHEMBL4564922 pKi 27.54 nM
Fc1ccc(Cl)c(-c2ccc(NC[C@H]3CC34CCN(CC3CCCCC3)CC4)nn2)c1 CHEMBL5178468 pIC50 27.54 nM
Cc1nnc2sc(C(=O)NC3CN(c4ccc(F)c(F)c4)C3)c(N)c2c1C CHEMBL4096833 pEC50 28.84 nM
O=C(NCCC1CCNCC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1 CHEMBL214029 Ki 29.0 nM
CCOC(=O)N1[C@@H]2CC[C@H]1C[C@H](CN1CC[C@H](N3C(=O)Cc4ccccc43)C1)C2 CHEMBL2336059 EC50 29.0 nM
CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1 CHEMBL4439675 pKi 29.51 nM
C#CCOc1noc2c1CNCCC2 CHEMBL69306 EC50 30.0 nM
O=C(CCCCCNC(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1)NC[C@H]1CCCN(CC2CCCCC2)C1 CHEMBL2112956 Ki 30.0 nM
Cc1c(Cl)nnc2sc(C(=O)NC3CN(c4cc(Cl)ncc4Cl)C3)c(N)c12 CHEMBL4794104 EC50 30.0 nM
C[N+](C)(C)C[C@@H]1COC[C@@](c2ccccc2)(C2CCCCC2)O1 CHEMBL4648229 pKi 30.9 nM
O=C(CCNC(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1)NCCC(=O)NC[C@H]1CCCN(CC2CCCCC2)C1 CHEMBL2112959 Ki 31.0 nM
O=C(NCC1CCN(CC2CCC2)CC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1 CHEMBL215189 Ki 31.0 nM
CN1CCC=C(c2nsnc2OCCCCCCCCCCCCO)C1 CHEMBL545077 Log Ki 31.62 nM
CCO[C@H]1CC[C@](C)(N2CCC(N3C(=O)Cc4ccc(C)cc43)CC2)CC1 CHEMBL1223804 pEC50 31.62 nM
OC(CCN1CCCCC1)(c1ccccc1)C1CC2C=CC1C2 CHEMBL1101 Ki 32.1 nM
O=C1CCc2ccccc2N1CCCN1CCC(CCCCCCCCCC2CCN(CCCN3C(=O)CCc4ccccc43)CC2)CC1 CHEMBL3354078 pKi 32.36 nM
Cc1nnc2sc(C(=O)NC3CN(c4ccc(F)cc4F)C3)c(N)c2c1C CHEMBL4078814 pEC50 32.36 nM
Fc1cc(F)c(F)c(-c2ccc(NC[C@@H]3CC34CCN(CC3CCOCC3)CC4)nn2)c1 CHEMBL5172967 IC50 33.0 nM
CN1CCC[C@H]1[C@H]1C[S+]([O-])[C@@](c2ccccc2)(C2CCCCC2)O1 CHEMBL493980 pKi 33.11 nM
C[N+]1(C)CCC[C@H]1c1ccc([C@](O)(c2ccccc2)C2CCCCC2)o1 CHEMBL568870 pKi 33.11 nM
Cc1nnc2sc(C(=O)NC3CN(c4ccncn4)C3)c(N)c2c1C CHEMBL4077183 pEC50 33.11 nM
Cc1nnc2sc(C(=O)NC3CN(c4cccnc4)C3)c(N)c2c1C CHEMBL4071560 pEC50 33.11 nM
Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1 CHEMBL490 Ki 34.0 nM
C[N+](C)(C)C[C@@H]1COC[C@](c2ccccc2)(C2CCCCC2)O1 CHEMBL4648939 pKi 35.48 nM
CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 CHEMBL221753 Ki 36.0 nM
CN1C[C@H](CNC(=O)OCc2ccccc2)C[C@@H]2c3cccc4c3c(cn4C)C[C@H]21 CHEMBL19215 Activity 36.9 nM
Cc1cc2ncnn2c2sc(C(=O)NC3Cc4ccccc4C3)c(N)c12 CHEMBL4452874 EC50 37.0 nM
Nc1c(C(=O)c2ccncc2)sc2nc(O)c3c(c12)CCCC3 CHEMBL4516136 EC50 37.0 nM
CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1 CHEMBL4555411 pKi 37.15 nM
COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC CHEMBL27673 Ki 38.0 nM
OC(CCCN1CCCCC1)(c1ccccc1)c1ccccc1 CHEMBL936 Ki 38.0 nM
C[N+]1(C)CCCC1c1ccc(C(c2ccccc2)c2ccccc2)o1 CHEMBL583027 pKi 38.02 nM
CC(=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1 CHEMBL4851265 pKi 38.02 nM
Cc1nnc2sc(C(=O)NC3CN(c4cncnc4)C3)c(N)c2c1C CHEMBL4070423 pEC50 38.9 nM
O=C(NC[C@@H]1CCCNC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1 CHEMBL438822 Ki 39.0 nM
CCCO[C@H]1CC[C@](C)(N2CCC(N3C(=O)Cc4ccc(C)cc43)CC2)CC1 CHEMBL1223803 pEC50 39.81 nM
Cc1cc(F)cnc1N1CCN(C(=O)CCCc2cccc3ncccc23)[C@H](C)C1 CHEMBL4757103 pIC50 39.81 nM
CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1 CHEMBL4596899 pKi 39.81 nM
CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1 CHEMBL4865939 pKi 39.81 nM
CCCCCCOc1nc2sc(C(=O)NC3CC3)c(N)c2c(C)c1Cl CHEMBL3770397 Kb 40.0 nM
COc1ccc(CNc2nn(C)c3c2sc2nnc(C)c(C)c23)cc1 CHEMBL4474325 EC50 40.0 nM
COc1ccccc1CNCCCCCCN1CCC(CCC2CCN(CCCCCCNCc3ccccc3OC)CC2)CC1 CHEMBL242345 Log Ki 40.74 nM
CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NCCN1CCN(CCC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1 CHEMBL4862098 pKi 40.74 nM
CN1CCC(CNC(=O)[C@H]2CCCN2C(=O)[C@@H]2C[C@@H](O)CN2C(=O)CC(c2ccc(F)cc2)(c2ccc(F)cc2)c2ccc(F)cc2)CC1 CHEMBL214342 Ki 41.0 nM
COc1cc(F)c(CNC(=O)c2sc3nnc(C)c(C)c3c2N)cc1F CHEMBL5276239 EC50 41.4 nM
[2H]C([2H])(C1CCOCC1)N1CCC2(CC1)C[C@H]2CNc1ccc(-c2cc(F)cc(F)c2F)nn1 CHEMBL5208649 pIC50 41.69 nM
CN1C2CCCC1C(OC(=O)OCC(Cl)(Cl)Cl)C2 CHEMBL314493 Ki 42.0 nM
O=C(NCC1CCNCC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1 CHEMBL215180 Ki 42.0 nM
CN(C)CCCN1c2ccccc2Sc2ccccc21 CHEMBL564 Ki 42.0 nM
CCOc1ccccc1C1CCN([C@@H]2CCC3(C2)CN(C(C)=O)C3)CC1 CHEMBL5423866 EC50 42.0 nM
CN1CCC[C@@H]1[C@@H]1C[S+]([O-])[C@](c2ccccc2)(C2CCCCC2)O1 CHEMBL493979 pKi 42.66 nM
O=C(CNC(=O)[C@@H]1CCCN1C(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1)NC[C@H]1CCCN(CC2CCCCC2)C1 CHEMBL2112961 Ki 43.0 nM
CC(=O)Nc1ccc(-c2ccc(NC[C@@H]3CC34CCN(CC3CCOCC3)CC4)nn2)cc1 CHEMBL5189893 Ki 43.3 nM
COc1ccc(CNC(=O)c2sc3nnc(C)c(C)c3c2N)c(F)c1F CHEMBL5269998 EC50 43.4 nM
COc1ccc([S@+]([O-])c2ccc(C(C#N)C3CCN(C4CCCCC4)CC3)cc2)cc1 CHEMBL2115126 Ki 45.05 nM
Cc1nc2cc(C)c3c(N)c(C(=O)NC4Cc5ccccc5C4)sc3n2n1 CHEMBL4586356 EC50 46.0 nM
Clc1ccc2c(c1)CCc1cccnc1C2=C1CCNCC1 CHEMBL1172 Ki 47.0 nM
CCOC(=O)N1CCC(CN2CCC3(CC2)CN(C(=O)N(C)C)c2ncccc23)CC1 CHEMBL3310802 EC50 47.0 nM
O=C(OC1CC2CCCC1N2)c1ccc([N+](=O)[O-])cc1 CHEMBL315428 Ki 48.0 nM
O=C(NCC1CCN(C2CCCC2)CC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(F)cc1)(c1ccc(F)cc1)c1ccc(F)cc1 CHEMBL212645 Ki 48.0 nM
Cc1nnc2sc(C(=O)NCc3ccc(-c4ccnc(F)c4)cc3)c(N)c2c1C CHEMBL4094439 pEC50 48.98 nM
CO/N=C(\C#N)C12CCCN(CC1)C2 CHEMBL135645 IC50 49.0 nM
COc1cc(N2CC(NC(=O)c3sc4nnc(C)c(C)c4c3N)C2)ccn1 CHEMBL4092128 pEC50 50.12 nM
CCCC(C)(C)C(=O)N(CC)CCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1 CHEMBL4440484 pKi 50.12 nM
COc1cccc(C#CCO/N=C2\CN3CC[C@@H]2C3)c1 CHEMBL262455 ED50 51.0 nM
Fc1ccc(F)c(-c2ccc(NC[C@@H]3CC34CCN(CC3CCOCC3)CC4)nn2)c1 CHEMBL5173887 pIC50 51.29 nM
CN(C)CCOC(c1ccccc1)c1ccccc1 CHEMBL657 Ki 52.0 nM
Cc1nc2sc(C(=O)NC3CCOC3)c(N)c2c(C)c1Cl CHEMBL2313402 EC50 52.0 nM
O=C(NCC1CCNCC1)[C@H]1CCCN1C(=O)[C@@H]1C[C@@H](O)CN1C(=O)CC(c1ccc(Cl)cc1)(c1ccc(Cl)cc1)c1ccc(Cl)cc1 CHEMBL378872 Ki 53.0 nM
Fc1cccc(-c2ccc(NC[C@@H]3CC34CCN(CC3CCOCC3)CC4)nn2)c1 CHEMBL5203077 pIC50 53.7 nM
O=C(OCCN1CCCC1)N1c2ccccc2Sc2ccccc21 CHEMBL481153 Ki 54.0 nM
CN1CCC[C@H]1c1ccc([C@](O)(c2ccccc2)C2CCCCC2)o1 CHEMBL571341 pKi 54.95 nM
Cc1nnc2sc(C(=O)NCc3ccc(-c4ccnnc4)cc3)c(N)c2c1C CHEMBL4068328 pEC50 54.95 nM
[2H]C([2H])([2H])Oc1ccc(CNC(=O)c2sc3nnc(C)c(C)c3c2N)cc1F CHEMBL5268842 EC50 55.7 nM
Cc1nc2sc(C(=O)NCc3ccncc3)c(N)c2c(C)c1Cl CHEMBL2057417 EC50 56.0 nM
N=C(N)NCCC[C@H](N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1 CHEMBL4537517 pKi 56.23 nM
Cc1nnc2sc(C(=O)N3CC(c4cccc(F)c4)C3)c(N)c2c1C CHEMBL4216213 EC50 57.0 nM
CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1 CHEMBL4543584 pKi 57.54 nM
CNCCCC12CCC(c3ccccc31)c1ccccc12 CHEMBL21731 Ki 58.0 nM
Cc1cccc(OC(=O)N2CC(NC(=O)c3sc4nnc(C)c(C)c4c3N)C2)c1 CHEMBL4075751 pEC50 58.88 nM
C[N+](C)(C)C[C@@H]1CO[C@](c2ccccc2)(C2CCCCC2)CO1 CHEMBL4648444 pKi 58.88 nM
CC(=O)N[C@@H](CCCN)C(=O)NC(=O)[C@H](C)NC(=O)[C@H](CCNC(=N)N)NCCN1CCN(CCC(=O)NC2CCN(CC(=O)N3c4ccccc4NC(=O)c4ccccc43)CC2)CC1 CHEMBL4869723 pKi 58.88 nM
Cc1nnc2sc(C(=O)NCc3ccc(O)c(F)c3)c(N)c2c1C CHEMBL5282936 EC50 59.1 nM
O=C(CCCNC(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1)NCCC(=O)NCC1CCCN(CC2CCCCC2)C1 CHEMBL369062 Ki 60.0 nM
Cc1nnc2sc3c(NCc4ccc5c(c4)OCCO5)nn(C)c3c2c1C CHEMBL4458844 EC50 60.0 nM
Cc1nc2cc(C)c3c(N)c(C(=O)NC4Cc5cccnc5C4)sc3n2n1 CHEMBL4532897 EC50 60.0 nM
Cc1cnnc2sc(C(=O)NC3Cc4ccccc4C3)c(N)c12 CHEMBL4751679 EC50 60.0 nM
Cc1c(Cl)nnc2sc(C(=O)NC3CN(c4ncc(C(F)(F)F)cn4)C3)c(N)c12 CHEMBL4780651 EC50 60.0 nM
CSc1ccc(CNC(=O)c2sc3nnc(C)c(C)c3c2N)cc1 CHEMBL3982695 EC50 60.2 nM
Cc1cc(CNC(=O)c2sc3nc(C)c(Cl)c(C)c3c2N)ccn1 CHEMBL2313379 EC50 61.0 nM
Cc1cccc(C(=O)N2CCC(N3CCC(Cc4ccc(S(=O)(=O)c5cccc(Cl)c5)cc4)CC3)CC2)c1N CHEMBL12098 Ki 61.0 nM
COc1ccc2c(c1)CCN1Cc3c(ccc4[nH]c(C)c(-c5nc(C)no5)c34)OC21 CHEMBL104803 Log Ki 61.66 nM
CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1 CHEMBL4451030 pKi 61.66 nM
CCN1CCC(c2ccccc2)=C(C(=O)OC2CCCCC2)C1 CHEMBL332980 IC50 62.0 nM
Cn1nnc2ccc3c(NC4CN(c5cc(Cl)ncc5Cl)C4)ncnc3c21 CHEMBL4640254 EC50 63.0 nM
COc1nsnc1OCCOCCOc1nsnc1C1=CCCN(C)C1 CHEMBL373888 Log Ki 63.1 nM
Cc1nnc2sc(C(=O)NCc3ccc(-c4cccnc4)cc3)c(N)c2c1C CHEMBL4097819 pEC50 63.1 nM
Cc1nnc2sc(C(=O)NCc3ccc(-c4ccc(F)nc4)cc3)c(N)c2c1C CHEMBL4102040 pEC50 63.1 nM
CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1 CHEMBL4596065 pKi 63.1 nM
C[N+]1(C)CCCC1c1ccc(C(O)(c2ccccc2)c2ccccc2)o1 CHEMBL569729 pKi 64.57 nM
CN(C)CCCCOC(=O)C(C)(c1ccccc1)C1CCCCC1 CHEMBL285440 Ki 65.6 nM
CCOc1noc2c1CNCCC2 CHEMBL69305 EC50 67.0 nM
CCCCOC(=O)c1c(C)[nH]c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3 CHEMBL106505 Log Ki 67.61 nM
C[N+]1=C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCCCC3CCN(CC(=O)N4c5ccccc5NC(=O)c5ccccc54)CC3)c3ccccc3C2(C)C)C(C)(C)c2ccccc21 CHEMBL4634575 pKi 67.61 nM
CC(=O)N[C@H](CCCN)C(=O)NC(=O)[C@H](CCNC(=N)N)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1 CHEMBL4846958 pKi 69.18 nM
CCN1CCC(c2ccccc2)=C(C(=O)OCCc2ccccc2)C1 CHEMBL262198 IC50 69.7 nM
Cc1c(Cl)nnc2sc(C(=O)NC3CN(c4ccnc(F)c4Cl)C3)c(N)c12 CHEMBL4787099 EC50 70.0 nM
CN(C)C[C@@H]1COCC(c2ccccc2)(c2ccccc2)O1 CHEMBL2042554 pKi 70.79 nM
CN(C)C[C@@H]1COCC(c2ccccc2)(c2ccccc2)O1 CHEMBL2078987 pKi 70.79 nM
C[N+](C)(C)C[C@@H]1CO[C@@](c2ccccc2)(C2CCCCC2)CO1 CHEMBL4635385 pKi 70.79 nM
Cc1nnc2sc(C(=O)N3CC(c4ccccc4)C3)c(N)c2c1C CHEMBL4211076 EC50 72.0 nM
Fc1ccccc1-c1ccc(NC[C@@H]2CC23CCN(CC2CCOCC2)CC3)nn1 CHEMBL5207446 IC50 72.0 nM
C=CCOC(=O)c1c(C)n(Cc2ccc(OC)cc2)c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3 CHEMBL104332 Log Ki 72.44 nM
COc1ccc2c(c1)CCN1Cc3c(ccc4[nH]c(C)c(C(=O)OCc5ccccc5)c34)OC21 CHEMBL104574 Log Ki 72.44 nM
O=C(CCCNC(=O)CNC(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1)NCC1CCCN(CC2CCCCC2)C1 CHEMBL177040 Ki 74.0 nM
OC(CCCN1CCC(C2CCN(CCCC(O)(c3ccccc3)c3ccccc3)CC2)CC1)(c1ccccc1)c1ccccc1 CHEMBL403773 Log Ki 74.13 nM
Cc1nnc2sc(C(=O)NC3CN(c4cnccn4)C3)c(N)c2c1C CHEMBL4098593 pEC50 74.13 nM
Cc1nnc2sc(C(=O)NC3CN(c4ccc(C(F)(F)F)nc4)C3)c(N)c2c1C CHEMBL4083081 pEC50 75.86 nM
Nc1c(C(=O)c2ccncc2)sc2nc(OCCN3CCOCC3)c3c(c12)CCC3 CHEMBL4544318 EC50 76.0 nM
Cc1nc2sc(C(=O)NC3CC3)c(N)c2c(C)c1Cl CHEMBL2313377 EC50 77.0 nM
CN1CCCC1c1ccc(C(c2ccccc2)C2CCCCC2)o1 CHEMBL576707 pKi 77.62 nM
O=C(C1CCN(c2cc(Oc3cc(F)ccc3F)ncn2)CC1)N1CCc2ccccc2C1 CHEMBL4088103 pIC50 77.62 nM
COc1ccc(CNC(=O)c2sc3nnc(C)c(C)c3c2N)cc1F CHEMBL4207737 EC50 78.8 nM
CC(=O)OCCCCCCCCCCCCOc1nsnc1C1=CCCN(C)C1 CHEMBL538793 Log Ki 79.43 nM
COc1nsnc1OCCOCCOCCOc1nsnc1C1=CCCN(C)C1 CHEMBL218755 Log Ki 79.43 nM
CC(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1 CHEMBL4456524 pKi 79.43 nM
Cn1c(=O)c2[nH]c(Cl)nc2n(C)c1=O CHEMBL1200406 Ki 80.0 nM
Cc1nc2sc(C(=O)NCc3ccc4c(c3)OCO4)c(N)c2c(C)c1Cl CHEMBL2313391 EC50 80.0 nM
CN(C)CCC1=C(C(C)(C)c2ccccn2)c2ccccc2C1 CHEMBL423831 Log Ki 81.28 nM
COc1ncc(-c2ccc(CNC(=O)c3sc4nnc(C)c(C)c4c3N)cc2)cn1 CHEMBL4067974 pEC50 83.18 nM
COc1ccc(CNC(=O)c2sc3c(c(C)cc4nc(C)nn43)c2N)cc1 CHEMBL4468120 EC50 84.0 nM
COc1c(F)cc(CNC(=O)c2sc3nnc(C)c(C)c3c2N)cc1F CHEMBL5285036 EC50 84.1 nM
CCC(=O)OC1CC2CCCC1N2 CHEMBL310558 Ki 85.0 nM
Cc1cc(C)c2c(n1)sc1c(NC3CCC3)nccc12 CHEMBL5078961 EC50 85.0 nM
CCOC(=O)N1[C@@H]2CC[C@H]1C[C@H](CN1CC[C@@H](N3Cc4ccccc4NC3=O)C1)C2 CHEMBL3633184 EC50 86.0 nM
Cc1cc2ncnn2c2sc(C(=O)NC3Cc4cccnc4C3)c(N)c12 CHEMBL4449879 EC50 86.0 nM
COc1ccc(CNC(=O)c2sc3c(c(C)cc4nncn43)c2N)cc1 CHEMBL4528914 EC50 89.0 nM
CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1 CHEMBL4454134 pKi 89.13 nM
CC[C@H](C)C(C(=O)OCCCN(CC)CC)c1ccccc1 CHEMBL2377392 Ki 89.6 nM
O=C1c2c(O)ccc(O)c2C(=O)c2c(NCCNCCO)ccc(NCCNCCO)c21 CHEMBL58 Ki 89.8 nM
Cc1noc(C)c1S(=O)(=O)N1CCN(c2ccc(N3CCCC[C@@H]3C)nn2)CC1 CHEMBL4094472 IC50 90.0 nM
Cc1nnc2sc(C(=O)NC3CN(c4ncc(C(F)(F)F)cn4)C3)c(N)c2c1C CHEMBL4796921 EC50 90.0 nM
COc1nnc2sc(C(=O)NC3CN(c4ncc(C(F)(F)F)cn4)C3)c(N)c2c1C CHEMBL4795177 EC50 90.0 nM
COc1ccc(CNC(=O)c2sc3nnc(C)c(C)c3c2N)c(F)c1 CHEMBL5272517 EC50 90.6 nM
Cc1nnc2sc(C(=O)NCc3ccc(-c4cccnc4F)cc3)c(N)c2c1C CHEMBL4091821 EC50 91.0 nM
Cc1nnc2sc(C(=O)NCc3ccc(S(=O)(=O)C(F)(F)F)cc3)c(N)c2c1C CHEMBL3915634 EC50 91.0 nM
Cn1nnc2ccc(C(=O)NC3CN(c4cc(Cl)ncc4Cl)C3)c(N)c21 CHEMBL4647876 EC50 91.0 nM
Cc1nnc2sc(C(=O)NC3CN(c4nc5cccnc5s4)C3)c(N)c2c1C CHEMBL4062934 pEC50 91.2 nM
Nc1ccccc1C(=O)N1CCC(N2CCC(Cc3ccc(S(=O)(=O)c4cccc(Cl)c4)cc3)CC2)CC1 CHEMBL4448933 pKi 91.2 nM
CCN1CCC(CNC(=O)[C@H]2CCCN2C(=O)[C@@H]2C[C@@H](O)CN2C(=O)CC(c2ccc(F)cc2)(c2ccc(F)cc2)c2ccc(F)cc2)CC1 CHEMBL213709 Ki 92.0 nM
COc1cccc(C#CCO/N=C2\CN3CCC2C3)c1 CHEMBL81878 ED50 93.0 nM
CCOC(=O)N1CCC(CN2CCC3(CC2)CN(S(C)(=O)=O)c2ncccc23)CC1 CHEMBL3289440 EC50 93.0 nM
CN1CCC[C@@H]1[C@@H]1C[S+]([O-])[C@@](c2ccccc2)(C2CCCCC2)O1 CHEMBL496915 pKi 93.33 nM
CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCCCCC1CCN(CC(=O)N2c3ccccc3NC(=O)c3ccccc32)CC1 CHEMBL4582069 pKi 93.33 nM
Cc1cc(OCc2ccncc2)nc2sc(C(=O)NCc3cccc(F)c3F)c(N)c12 CHEMBL1589763 EC50 95.0 nM
COc1ccc(CNC(=O)c2sc3c(c(C)cc4ncnn43)c2N)cc1 CHEMBL4533756 EC50 95.0 nM
C[N+](C)(C)C[C@@H]1C[S+]([O-])[C@@](c2ccccc2)(C2CCCCC2)O1 CHEMBL557808 pKi 95.5 nM
O=C1CCc2ccccc2N1CCCN1CCC(CCCCCCCCCCCCCO)CC1 CHEMBL3354077 pKi 95.5 nM
CC[C@@H]1C(=O)OC[C@@H]1Cc1c[n+](CCCCCCCC[N+](C)(C)CC(C)(C)CN2C(=O)c3cccc4cccc(c34)C2=O)cn1C CHEMBL5274545 pEC50 95.5 nM
c1ccc(CN2CCC(CCNc3cc4c(nn3)-c3ccccc3CCCC4)CC2)cc1 CHEMBL4849905 IC50 96.0 nM
Cc1nnc2sc(C(=O)NCc3ccc(O)cc3)c(N)c2c1C CHEMBL5265891 EC50 96.7 nM
CC(C1=C(CN(C)C)Cc2ccccc21)c1ccccn1 CHEMBL434684 Log Ki 97.72 nM
CCOC(=O)c1c(CC)n(Cc2ccccc2)c2ccc3c(c12)CN1CCc2cc(OC)ccc2C1O3 CHEMBL106219 Log Ki 97.72 nM
CN(C)C[C@@H]1COC[C@](c2ccccc2)(C2CCCCC2)O1 CHEMBL4644285 pKi 97.72 nM