CN1CCN(c2cc(C(=O)Nc3cc4cc(-c5cnn(C)c5)ccc4cn3)ccn2)CC1 CHEMBL4784318 IC50 2.2 nM
CC(C)c1cnn2c(NCc3ccc(-c4ccccn4)cc3)nc(N[C@H]3CC[C@H](N)CC3)nc12 CHEMBL4284209 IC50 2.9 nM
c1cncc(-c2ccc3[nH]nc(-c4cc5c(-c6cccnc6)cncc5[nH]4)c3c2)c1 CHEMBL4748515 EC50 3.0 nM
CN1CCC(n2cc(C(=O)Nc3cc4cc(-c5cnn(C)c5)ccc4cn3)cn2)CC1 CHEMBL4761662 EC50 6.0 nM
CNc1nc(NCc2ncccn2)c2c(-c3ccc4ncccc4c3)c[nH]c2n1 CHEMBL4797564 Kd 6.5 nM
CN(C)Cc1cncc(-c2cnc3[nH]nc(-c4nc5c(-c6cccc(F)c6)cncc5[nH]4)c3c2)c1 CHEMBL4740064 EC50 7.0 nM
CN1CCC(n2cc(C(=O)Nc3cc4cc(-c5cncc6[nH]ccc56)ccc4cn3)cn2)CC1 CHEMBL4746469 EC50 7.0 nM
Cn1ncc(-c2ccc3cnc(NC(=O)c4ccnc(N5CCOCC5)c4)cc3c2)c1CN1CCOCC1 CHEMBL4782826 EC50 8.0 nM
C[C@@H](c1ccc(F)cc1)n1nnc2cnc3ccc(-c4ccc5ocnc5c4)cc3c21 CHEMBL4083249 IC50 8.0 nM
Cc1ccc(-c2cncc3[nH]c(-c4n[nH]c5ccc(-c6cncc(N)c6)nc45)nc23)s1 CHEMBL4754110 EC50 9.0 nM
CN(C)C1CCN(c2cc(C(=O)Nc3cc4cc(-c5cnn(C)c5)ccc4cn3)ccn2)CC1 CHEMBL4741472 EC50 9.0 nM
CN1CCC(n2cc(C(=O)Nc3cc4cc(-c5cnc6cc[nH]c6c5)ccc4cn3)cn2)CC1 CHEMBL4745584 EC50 9.0 nM
O=C(O)c1ccc2c(c1)nc(Nc1cccc(Cl)c1)c1ccncc12 CHEMBL1230165 Kd apparent 10.0 nM
CN1CCN(c2cc(Nc3ncc4c(-c5ccc6ncccc6c5)c[nH]c4n3)ccn2)CC1 CHEMBL4798969 EC50 10.0 nM
NC[C@@H](NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1)c1ccccc1 CHEMBL5441121 IC50 10.0 nM
CN1CCN(c2ccc(NC(=O)c3n[nH]c4ccc(-c5cncc(CN6CCC(F)(F)C6)c5)cc34)cn2)CC1 CHEMBL4761354 EC50 11.0 nM
NC(=O)c1ccc(NC(=O)c2n[nH]c3ccc(-c4cncc(CN5CCCCC5)c4)cc23)cn1 CHEMBL4779592 EC50 11.0 nM
O=C(Nc1ccnnc1)c1n[nH]c2ccc(-c3cncc(CN4CCCCC4)c3)cc12 CHEMBL4748995 EC50 11.0 nM
Cn1cncc1-c1ccc2cnc(NC(=O)c3ccnc(N4CC(N)C4)c3)cc2c1 CHEMBL4780597 EC50 11.0 nM
CC(C)Nc1cncc(-c2ccc3cnc(NC(=O)c4cccc(C5CCN(C)CC5)c4)cc3c2)n1 CHEMBL4797241 EC50 11.0 nM
O=C(Nc1cc2cc(-c3cncc(N[C@H]4CCNC[C@@H]4F)n3)ccc2cn1)C1CC1 CHEMBL4780537 EC50 11.0 nM
Cc1ccc([N+](=O)[O-])cc1S(=O)(=O)N(C)/N=C/c1cnc2ccc(Br)cn12 CHEMBL393525 IC50 11.9 nM
O=C(NC1CCNCC1)c1n[nH]cc1NC(=O)c1c(Cl)cccc1Cl CHEMBL445813 Kd apparent 12.0 nM
O=C(Nc1ccc(C(=O)N2CCCC2)nc1)c1n[nH]c2ccc(-c3cncc(CN4CCCCC4)c3)cc12 CHEMBL4752625 EC50 12.0 nM
CN(C)c1cncc(-c2ccc3[nH]nc(-c4nc5c(-c6cccc(F)c6)cncc5[nH]4)c3n2)c1 CHEMBL4783783 EC50 12.0 nM
Nc1cncc(-c2ccc3[nH]nc(-c4nc5c(-c6ccccc6F)cncc5[nH]4)c3n2)c1 CHEMBL4786746 EC50 12.0 nM
CN1CC=C(c2cc(C(=O)Nc3cc4cc(-c5cncc(NC(C)(C)C)n5)cnc4cn3)ccn2)CC1 CHEMBL4800068 EC50 12.0 nM
CN1CCCCN(C)c2nccc3[nH]c(nc23)-c2c[nH]c3ccc(cc23)-c2cncc(c2)C1 CHEMBL4741101 EC50 12.0 nM
c1cc2cc(c1)-c1cncc3[nH]c(nc13)-c1n[nH]c3ccc(cc13)-c1cncc(c1)CNC2 CHEMBL4793171 EC50 12.0 nM
COc1ccc(F)c(F)c1C(=O)c1cnc(NC2CCN(S(C)(=O)=O)CC2)nc1N CHEMBL384304 Kd 13.0 nM
CN1CCN(c2ccc(NC(=O)c3n[nH]c4ccc(-c5cncc(NC(=O)C6CC6)c5)cc34)cn2)CC1 CHEMBL4742870 EC50 13.0 nM
CC(C)CC(=O)Nc1cncc(-c2cc3c(-c4nc5c(-c6cc(F)cc(OCCN7CCCC7)c6)cncc5[nH]4)n[nH]c3cn2)c1 CHEMBL4746668 EC50 13.0 nM
CC(C)n1cc(C(=O)Nc2cc3cc(-c4cncn4C)ccc3cn2)cn1 CHEMBL4755579 EC50 13.0 nM
CN(C)CCN(C)c1ccc(NC(=O)c2n[nH]c3ccc(-c4cncc(CN5CCCCC5)c4)cc23)cn1 CHEMBL4742725 EC50 14.0 nM
CS(=O)(=O)c1ccc(NC(=O)c2n[nH]c3ccc(-c4cncc(CN5CCCCC5)c4)cc23)cn1 CHEMBL4788275 EC50 14.0 nM
CN1CCC(Oc2ccc(C(=O)Nc3cc4cc(-c5cnn(C)c5)ccc4cn3)cc2)CC1 CHEMBL4748484 EC50 14.0 nM
Cc1nnc(-c2ccc3cnc(NC(=O)c4ccnc(C5=CCN(C)CC5)c4)cc3c2)s1 CHEMBL4799760 EC50 14.0 nM
c1cncc(-c2ccc3[nH]nc(-c4cc5cnccc5[nH]4)c3c2)c1 CHEMBL4759361 EC50 15.0 nM
Cn1ncc(-c2ccc3cnc(NC(=O)c4cccc(CN5CCCC5)c4)cc3c2)c1CN1CCCCC1 CHEMBL4740518 EC50 15.0 nM
Cc1cn(-c2cncc3[nH]c(-c4n[nH]c5ccc(-c6cncc(NC(=O)CC(C)C)c6)cc45)nc23)cn1 CHEMBL4747740 EC50 16.0 nM
CC(C)C(=O)Nc1cncc(-c2cc3c(-c4cc5cnccc5[nH]4)n[nH]c3cn2)c1 CHEMBL4745415 EC50 16.0 nM
CN1CCC2(CC1)CN(c1cc(C(=O)Nc3cc4cc(-c5cnn(C)c5)ccc4cn3)ccn1)C2 CHEMBL4748909 EC50 16.0 nM
O=C1COc2cccc(c2)-c2cncc3[nH]c(nc23)-c2n[nH]c3ccc(cc23)-c2cncc(c2)N1 CHEMBL4800405 EC50 16.0 nM
Nc1ncc(NC(=O)c2n[nH]c3ccc(-c4cncc(CN5CCCCC5)c4)cc23)cn1 CHEMBL4786934 EC50 17.0 nM
c1cncc(-c2cnc3[nH]nc(-c4nc5c(-c6cccnc6)cncc5[nH]4)c3c2)c1 CHEMBL4745260 EC50 17.0 nM
O=C(Nc1cncc(-c2ccc3[nH]nc(-c4nc5c(-c6cccnc6)cncc5[nH]4)c3c2)c1)c1ccccc1 CHEMBL4786564 EC50 17.0 nM
Cc1ccncc1-c1cc2c(-c3nc4c(-c5cc(F)cc(CNS(C)(=O)=O)c5)cncc4[nH]3)n[nH]c2cn1 CHEMBL4791409 EC50 17.0 nM
CN(C)C(=O)Nc1cncc(-c2cnc3[nH]nc(-c4nc5c(-c6cccc(F)c6)cncc5[nH]4)c3c2)c1 CHEMBL4755351 EC50 18.0 nM
Nc1cncc(-c2ccc3[nH]nc(-c4cc5c(-c6cccnc6)nccc5[nH]4)c3c2)c1 CHEMBL4749420 EC50 18.0 nM
O=C(Nc1cncc(-c2ccc3[nH]nc(-c4cc5cnccc5[nH]4)c3c2)c1)C1CCCCC1 CHEMBL4779458 EC50 18.0 nM
Cn1cncc1-c1ccc2cnc(NC(=O)c3ccnc(N4CCN(C5CC5)CC4)c3)cc2c1 CHEMBL4758853 EC50 18.0 nM
O=C(Nc1cc2cc(-c3cncc(NCC4(F)CNC4)n3)ccc2cn1)C1CC1 CHEMBL4777070 EC50 18.0 nM
Nc1cncc(-c2ccc3[nH]nc(-c4nc5c(-c6ccccc6F)ccnc5[nH]4)c3c2)c1 CHEMBL4758175 EC50 19.0 nM
Nc1cncc(-c2ccc3[nH]nc(-c4cc5c(-c6ccccn6)ccnc5[nH]4)c3c2)c1 CHEMBL4750609 EC50 19.0 nM
O=C(Nc1cncc(-c2ccc3[nH]nc(-c4cc5cnccc5[nH]4)c3c2)c1)C1CCC1 CHEMBL4797292 EC50 19.0 nM
c1cnc2cc(-c3n[nH]c4ccc(-c5cncc(CN6CCCCC6)c5)cc34)[nH]c2c1 CHEMBL4764806 EC50 19.0 nM
CC(C)N1CCC(n2cc(C(=O)Nc3cc4cc(-c5cn(C)nn5)ccc4cn3)cn2)CC1 CHEMBL4795948 EC50 19.0 nM
Cc1nnc(-c2ccc3cnc(NC(=O)c4ccnc(N(C)C5CCN(C)CC5)c4)cc3c2)s1 CHEMBL4788867 EC50 19.0 nM
CN1CCC(n2cc(C(=O)Nc3ncc4ccc(-c5cncc6[nH]ccc56)cc4n3)cn2)CC1 CHEMBL4748839 EC50 19.0 nM
CN(C)C(=O)Nc1cncc(-c2ccc3[nH]nc(C(=O)Nc4cccnc4)c3c2)c1 CHEMBL4750147 EC50 20.0 nM
Nc1cncc(-c2ccc3[nH]nc(-c4nc5c(-c6ccccc6F)nccc5[nH]4)c3c2)c1 CHEMBL4761232 EC50 20.0 nM
Cc1ccc(-c2nccc3[nH]c(-c4n[nH]c5ccc(-c6cncc(N)c6)nc45)nc23)s1 CHEMBL4778742 EC50 20.0 nM
CC(C)OC(=O)N1CCC(n2cc(C(=O)Nc3cc4cc(-c5cnn(C)c5)ccc4cn3)cn2)CC1 CHEMBL4746707 EC50 20.0 nM
CC(C)N1CCC(c2nc(C(=O)Nc3cc4cc(-c5cnn(C)c5)ccc4cn3)co2)CC1 CHEMBL4762553 EC50 20.0 nM
CN1CCN(c2cc(C(=O)Nc3cc4cc(-c5cncs5)ccc4cn3)ccn2)CC1 CHEMBL4744439 EC50 20.0 nM
O=C(Nc1ccnnc1)c1n[nH]c2ccc(-c3cccnc3)cc12 CHEMBL4746176 EC50 21.0 nM
CCCC(=O)Nc1cncc(-c2cc3c(-c4nc5c(-c6ccsc6)cncc5[nH]4)n[nH]c3cn2)c1 CHEMBL4786673 EC50 21.0 nM
CCC(=O)Nc1cncc(-c2ccc3[nH]nc(-c4cc5c(-c6cccc(F)c6)ccnc5[nH]4)c3c2)c1 CHEMBL4788382 EC50 21.0 nM
CN1CCN(c2cc(C(=O)Nc3cc4cc(-c5cnn(C)c5)c(F)cc4cn3)ccn2)CC1 CHEMBL4778468 EC50 21.0 nM
CN1CCC(Nc2cc(C(=O)Nc3cc4cc(-c5cnn(C)c5)ccc4cn3)ccn2)CC1 CHEMBL4743755 EC50 21.0 nM
COc1ccc(NC(=O)c2n[nH]c3ccc(-c4cncc(CN5CCC(F)(F)C5)c4)cc23)cn1 CHEMBL4779515 EC50 22.0 nM
O=C(Nc1ccc(N2CCC(O)CC2)nc1)c1n[nH]c2ccc(-c3cncc(CN4CCCCC4)c3)cc12 CHEMBL4756030 EC50 22.0 nM
CCN(C)Cc1cncc(-c2cnc3[nH]nc(-c4nc5c(-c6cccc(F)c6)cncc5[nH]4)c3c2)c1 CHEMBL4765065 EC50 22.0 nM
CN1CCN(c2cc(C(=O)Nc3cc4cc(-c5cnc(N)s5)ccc4cn3)ccn2)CC1 CHEMBL4747892 EC50 22.0 nM
CC(C)(C)C(=O)Nc1cncc(-c2ccc3[nH]nc(-c4nc5c(-c6cccnc6)cncc5[nH]4)c3c2)c1 CHEMBL4755029 EC50 23.0 nM
FC1(F)CCN(Cc2cncc(-c3ccc4[nH]nc(-c5cc6cnccc6[nH]5)c4n3)c2)C1 CHEMBL4763390 EC50 23.0 nM
CC(C)n1cc(C(=O)Nc2cc3cc(-c4cncn4C(C)C)ccc3cn2)cn1 CHEMBL4754087 EC50 23.0 nM
NCC(NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1)c1ccccc1 CHEMBL5438728 IC50 23.0 nM
CC(C)C(=O)Nc1cncc(-c2ccc3[nH]nc(-c4nc5c(-c6ccccc6F)cncc5[nH]4)c3c2)c1 CHEMBL4792507 EC50 24.0 nM
CC(C)CC(=O)Nc1cncc(-c2ccc3[nH]nc(-c4nc5c(-c6cc(F)cc(NCCN(C)C)c6)cncc5[nH]4)c3c2)c1 CHEMBL4749868 EC50 25.0 nM
CC(C)Nc1cncc(-c2ccc3[nH]nc(-c4nc5c(-c6cc(F)cc(NCCN(C)C)c6)cncc5[nH]4)c3n2)c1 CHEMBL4754511 EC50 25.0 nM
CN(C)Cc1cncc(-c2cnc3[nH]nc(-c4nc5c(-c6cc(F)cc(N7CCOCC7)c6)cncc5[nH]4)c3c2)c1 CHEMBL4745861 EC50 25.0 nM
CC(C)CC(=O)Nc1cncc(-c2ccc3[nH]nc(-c4nc5c(-c6cccnc6)cncc5[nH]4)c3c2)c1 CHEMBL4754321 EC50 26.0 nM
CN1CCN(c2nccc3[nH]c(-c4n[nH]c5cc(F)c(-c6cnn(C)c6)cc45)nc23)CC1 CHEMBL4789036 EC50 26.0 nM
FC1(F)CCN(Cc2cncc(-c3ccc4[nH]nc(-c5nc6c(-c7ccsc7)cncc6[nH]5)c4c3)c2)C1 CHEMBL4788582 EC50 26.0 nM
Cc1cc(C(=O)Nc2cc3cc(-c4cnn(C)c4)ccc3cn2)cc(N2CCN(C)CC2)n1 CHEMBL4748781 EC50 26.0 nM
Cn1cc(-c2ccc3cnc(NC(=O)c4ccnc(N5CC6CC5CN6)c4)cc3c2)cn1 CHEMBL4791671 EC50 26.0 nM
CC(C)N1CCC(Oc2cc(C(=O)Nc3cc4cc(-c5cnn6c5CCNC6)ccc4cn3)ccn2)CC1 CHEMBL4762157 EC50 26.0 nM
CN1CCCn2cc(nn2)-c2nccc3[nH]c(nc23)-c2n[nH]c3ccc(cc23)-c2cncc(c2)C1 CHEMBL4791855 EC50 26.0 nM
CN1Cc2ccc(C(=O)Nc3cc4cc(-c5cncn5C)ccc4cn3)cc2C1 CHEMBL4786449 EC50 27.0 nM
O=C(CC1CCNCC1)Nc1cncc(-c2cc3c(-c4nc5c(-c6cccc(F)c6)ccnc5[nH]4)n[nH]c3cn2)c1 CHEMBL4782145 EC50 28.0 nM
c1cc2[nH]c(-c3n[nH]c4ccc(-c5cncc(CN6CCCCC6)c5)cc34)cc2cn1 CHEMBL4754457 EC50 28.0 nM
CN1CCCN(c2cc(C(=O)Nc3cc4cc(-c5cnn(C)c5)ccc4cn3)ccn2)CC1 CHEMBL4789887 EC50 28.0 nM
O=C1NCc2ccc3c(-c4cccc(Cl)c4)c[nH]c3c21 CHEMBL4796016 IC50 28.0 nM
Cc1ccc(-c2nccc3[nH]c(-c4n[nH]c5cnc(-c6cncc(N)c6)cc45)nc23)s1 CHEMBL4778624 EC50 29.0 nM
Cc1ccc(-c2cncc3[nH]c(-c4n[nH]c5cnc(-c6cncc(NC(=O)C7CCC7)c6)cc45)nc23)s1 CHEMBL4790414 EC50 29.0 nM
CN1CCC(Oc2ccc3[nH]c(-c4n[nH]c5ccc(-c6cnn(C)c6)cc45)nc3c2)CC1 CHEMBL4744523 EC50 29.0 nM
CC(C)CC(=O)Nc1cncc(-c2ccc3[nH]nc(-c4cc5c(-c6ccncc6)cncc5[nH]4)c3c2)c1 CHEMBL4760110 EC50 29.0 nM
O=C1CCc2cccc(c2)-c2cncc3[nH]c(nc23)-c2n[nH]c3ccc(cc23)-c2cncc(c2)N1 CHEMBL4753134 EC50 29.0 nM
Nc1nc(Nc2ccc(S(N)(=O)=O)cc2)nn1C(=S)Nc1c(F)cccc1F CHEMBL261720 IC50 29.2 nM
CCC(=O)Nc1cncc(-c2ccc3[nH]nc(-c4nc5c(-c6cccc(F)c6)ccnc5[nH]4)c3n2)c1 CHEMBL4758546 EC50 30.0 nM
CCNCc1cncc(-c2cc3c(-c4nc5c(-c6ccsc6)nccc5[nH]4)n[nH]c3cn2)c1 CHEMBL4755887 EC50 30.0 nM
O=C(Nc1cncc(-c2ccc3[nH]nc(-c4cc5c(-c6ccncc6)nccc5[nH]4)c3c2)c1)C1CCCC1 CHEMBL4786493 EC50 30.0 nM
CN(C)CCOc1cc(C(=O)Nc2cc3cc(-c4cnn(C)c4)ccc3cn2)ccn1 CHEMBL4783105 EC50 30.0 nM
CNCC(NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1)c1ccccc1 CHEMBL5439276 IC50 30.0 nM
Cc1ccncc1-c1ccc2[nH]nc(-c3cc4ccncc4[nH]3)c2c1 CHEMBL4761131 EC50 31.0 nM
Cc1ncc(C(=O)Nc2cc3cc(-c4cnc(C)n4C)ccc3cn2)s1 CHEMBL4800296 EC50 31.0 nM
CN1CCC2(CC1)CN(c1cc(C(=O)Nc3cc4cc(-c5cnn(C)c5CN5CCCCC5)cnc4cn3)ccn1)C2 CHEMBL4779822 EC50 31.0 nM
Cc1ncc(C(=O)Nc2cc3nc(-c4cnc(C)n4C)ccc3cn2)s1 CHEMBL4790079 EC50 31.0 nM
COc1ccc(NC(=O)c2n[nH]c3ccc(-c4cncc(CN5CCCCC5)c4)cc23)cn1 CHEMBL4800084 EC50 32.0 nM
CN1CCN(c2cncc3[nH]c(-c4n[nH]c5ccc(-c6cncc(N7CCOCC7)c6)cc45)nc23)CC1 CHEMBL4760982 EC50 32.0 nM
O=C(CC1CCNCC1)Nc1cncc(-c2ccc3[nH]nc(-c4cc5c(-c6ccccn6)cccc5[nH]4)c3n2)c1 CHEMBL4755473 EC50 32.0 nM
Fc1cccc(-c2cncc3[nH]c(-c4n[nH]c5ccc(-c6cncc(CN7CCC(F)(F)C7)c6)cc45)nc23)c1 CHEMBL4761890 EC50 33.0 nM
Fc1cccc(-c2cncc3[nH]c(-c4n[nH]c5cnc(-c6cncc(OC7CCNCC7)c6)cc45)nc23)c1 CHEMBL4762436 EC50 33.0 nM
CC(C)Nc1cncc(-c2cnc3[nH]nc(-c4nc5c(-c6cc(F)cc(NCCN(C)C)c6)nccc5[nH]4)c3c2)c1 CHEMBL4749014 EC50 33.0 nM
CCC(=O)Nc1cncc(-c2cnc3[nH]nc(-c4cc5c(-c6cccc(F)c6)cncc5[nH]4)c3c2)c1 CHEMBL4779327 EC50 33.0 nM
Nc1cncc(-c2ccc3[nH]nc(-c4cc5c(-c6ccccc6F)ccnc5[nH]4)c3c2)c1 CHEMBL4755268 EC50 33.0 nM
Cn1cncc1-c1ccc2cnc(NC(=O)c3ccc(F)cc3)cc2c1 CHEMBL4783628 EC50 33.0 nM
CN1CCN(Cc2ccc(NC(=O)c3n[nH]c4ccc(-c5cccnc5)cc34)cn2)CC1 CHEMBL4760183 EC50 34.0 nM
Cc1ncc(-c2cnc3[nH]nc(-c4nc5c(-c6cccc(F)c6)nccc5[nH]4)c3c2)n1C CHEMBL4791974 EC50 34.0 nM
Nc1cncc(-c2ccc3[nH]nc(-c4nc5c(-c6ccccc6F)ccnc5[nH]4)c3n2)c1 CHEMBL4755429 EC50 34.0 nM
FC1(F)CCN(Cc2cncc(-c3cnc4[nH]nc(-c5nc6c(-c7ccoc7)nccc6[nH]5)c4c3)c2)C1 CHEMBL4742707 EC50 34.0 nM
Cc1ccc(-c2cccc3[nH]c(-c4n[nH]c5ccc(-c6cncc(N)c6)nc45)nc23)s1 CHEMBL4749604 EC50 34.0 nM
CN1CCN(c2cc(C(=O)Nc3cc4cc(-c5cnn(C)c5N)ccc4cn3)ccn2)CC1 CHEMBL4793867 EC50 34.0 nM
Fc1ccc(-c2cncc3[nH]c(-c4n[nH]c5cnc(-c6cncc(CN7CCCC7)c6)cc45)nc23)s1 CHEMBL4778226 EC50 35.0 nM
CN(C)Cc1cncc(NC(=O)c2n[nH]c3ccc(-c4cncc(CN5CCCC5)c4)cc23)c1 CHEMBL4795039 EC50 36.0 nM
CN(C)CCNc1cc(F)cc(-c2cncc3[nH]c(-c4n[nH]c5ncc(-c6cccnc6)cc45)nc23)c1 CHEMBL4740704 EC50 36.0 nM
CN1CCN(c2ccc(C(=O)Nc3cc4cc(-c5cnn(C)c5)ccc4cn3)cn2)CC1 CHEMBL4800211 EC50 36.0 nM
O=C1CCc2cccc(c2)-c2cncc(c2)NC(=O)c2n[nH]c3ccc(cc23)-c2cncc(c2)CN1 CHEMBL4784103 EC50 36.0 nM
O=C(Nc1cccnc1)c1n[nH]c2ccc(-c3cncc(CN4CCS(=O)(=O)CC4)c3)cc12 CHEMBL4764569 EC50 37.0 nM
CN(C)c1cncc(-c2ccc3[nH]nc(-c4nc5c(-c6cccc(F)c6)ccnc5[nH]4)c3n2)c1 CHEMBL4755308 EC50 37.0 nM
CCC(=O)Nc1cncc(-c2cnc3[nH]nc(-c4nc5c(-c6ccc(F)cc6)cncc5[nH]4)c3c2)c1 CHEMBL4783909 EC50 37.0 nM
CC(C)C(=O)Nc1cncc(-c2ccc3[nH]nc(-c4nc5c(-c6cccnc6)cncc5[nH]4)c3c2)c1 CHEMBL4762778 EC50 37.0 nM
Cc1ccncc1-c1cc2c(-c3nc4c(-c5cc(F)cc(CNS(C)(=O)=O)c5)cccc4[nH]3)n[nH]c2cn1 CHEMBL4790637 EC50 37.0 nM
CN(C)Cc1cncc(-c2ccc3[nH]nc(-c4cc5c(-c6cccc(F)c6)cncc5[nH]4)c3c2)c1 CHEMBL4799281 EC50 37.0 nM
CC(C)C(=O)Nc1cncc(-c2ccc3[nH]nc(-c4cc5c(-c6cccnc6)cncc5[nH]4)c3c2)c1 CHEMBL4758034 EC50 37.0 nM
CN(C)C1CN(c2ncc(C(=O)Nc3cc4cc(-c5cnn(C)c5)ccc4cn3)s2)C1 CHEMBL4762838 EC50 37.0 nM
CC(C)CC(=O)Nc1cncc(-c2ccc3[nH]nc(-c4cc5c(-c6cc(F)cc(CNS(C)(=O)=O)c6)nccc5[nH]4)c3n2)c1 CHEMBL4740181 EC50 38.0 nM
Cn1cc(-c2ccc3cnc(NC(=O)c4ccnc(OC5CNC5)c4)cc3c2)cn1 CHEMBL4777508 EC50 38.0 nM
O=C1NC(NC[C@H](O)c2ccccc2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5430262 IC50 38.0 nM
O=C(Nc1ccc(N2CC(CO)(CO)C2)nc1)c1n[nH]c2ccc(-c3cncc(CN4CCCCC4)c3)cc12 CHEMBL4782319 EC50 39.0 nM
O=C(Nc1cncc(-c2cnc3[nH]nc(-c4nc5c(-c6cccnc6)cncc5[nH]4)c3c2)c1)C1CC1 CHEMBL4756460 EC50 39.0 nM
Cc1ccncc1-c1cnc2[nH]nc(-c3nc4c(-c5cc(F)cc(CNS(C)(=O)=O)c5)nccc4[nH]3)c2c1 CHEMBL4763405 EC50 39.0 nM
CCCC(=O)Nc1cncc(-c2cnc3[nH]nc(-c4cc5c(-c6cc(F)cc(CNS(C)(=O)=O)c6)cncc5[nH]4)c3c2)c1 CHEMBL4796752 EC50 39.0 nM
Cn1cc(-c2ccc3cnc(NC(=O)c4ccc5c(c4)CNCC5)cc3c2)cn1 CHEMBL4745735 EC50 39.0 nM
COc1cc(OC)c(/C=C/S(=O)(=O)Cc2ccc(OC)c(NCC(=O)O)c2)c(OC)c1 CHEMBL1241855 Kd apparent 40.0 nM
CC(C)CC(=O)Nc1cncc(-c2ccc3[nH]nc(-c4nc5c(N6CCN(C)CC6)cccc5[nH]4)c3c2)c1 CHEMBL4780561 EC50 40.0 nM
CN1CCN(c2cncc3[nH]c(-c4n[nH]c5ccc(-c6cncc(N)c6)cc45)cc23)CC1 CHEMBL4797723 EC50 40.0 nM
NC1CN(c2cc(C(=O)Nc3cc4cc(-c5cnco5)ccc4cn3)ccn2)C1 CHEMBL4741620 EC50 40.0 nM
COc1ccc(NC(=O)c2n[nH]c3ccc(-c4cncc(CO)c4)cc23)cn1 CHEMBL4797346 EC50 41.0 nM
CN(C)Cc1cncc(-c2cc3c(-c4nc5c(-c6cccc(F)c6)cccc5[nH]4)n[nH]c3cn2)c1 CHEMBL4782720 EC50 41.0 nM
CCC(=O)Nc1cncc(-c2cnc3[nH]nc(-c4cc5cnccc5[nH]4)c3c2)c1 CHEMBL4755477 EC50 41.0 nM
CN(C)Cc1ccc(C(=O)Nc2cc3cc(-c4cnn(C)c4)ccc3cn2)cc1 CHEMBL4755642 EC50 41.0 nM
O=C(Nc1cncc(-c2cnc3[nH]nc(-c4nc5c(-c6cccc(F)c6)cncc5[nH]4)c3c2)c1)N1CCOCC1 CHEMBL4799714 EC50 42.0 nM
O=C(Nc1cncc(-c2cnc3[nH]nc(-c4cc5c(-c6ccccc6F)cncc5[nH]4)c3c2)c1)C1CC1 CHEMBL4753703 EC50 42.0 nM
CCCCC(=O)Nc1cncc(-c2ccc3[nH]nc(-c4cc5c(-c6ccoc6)cncc5[nH]4)c3c2)c1 CHEMBL4790169 EC50 42.0 nM
CN1CCN(c2cc(C(=O)Nc3cc4cc(-c5ccc(N)nc5)ccc4cn3)ccn2)CC1 CHEMBL4782831 EC50 42.0 nM
c1cncc(-c2cnc3[nH]nc(-c4nc5c(-c6cccs6)cccc5[nH]4)c3c2)c1 CHEMBL4793606 EC50 43.0 nM
O=C(Nc1cncc(-c2ccc3[nH]nc(-c4cc5c(-c6cccnc6)nccc5[nH]4)c3c2)c1)c1ccccc1 CHEMBL4755598 EC50 43.0 nM
CN1CCN(c2cc(C(=O)Nc3cc4c(Cl)c(-c5cnn(C)c5)ccc4cn3)ccn2)CC1 CHEMBL4758035 EC50 43.0 nM
O=C(Nc1cc2cc(-c3cncs3)ccc2cn1)c1ccc2c(c1)CNCC2 CHEMBL4760089 EC50 43.0 nM
Cc1ccc(NC(=O)c2n[nH]c3ccc(-c4cncc(CN5CCCCC5)c4)cc23)cn1 CHEMBL4754606 EC50 44.0 nM
O=C(Nc1cccnc1)c1n[nH]c2ccc(-c3cncc(CN4CC5CC(C4)O5)c3)cc12 CHEMBL4743240 EC50 44.0 nM
c1cncc(-c2ccc3[nH]nc(-c4nc5c(-c6ccoc6)cncc5[nH]4)c3c2)c1 CHEMBL4749618 EC50 44.0 nM
Cc1ncc(-c2ccc3[nH]nc(-c4nc5c(-c6cc(F)cc(NCCN(C)C)c6)ccnc5[nH]4)c3n2)n1C CHEMBL4790085 EC50 44.0 nM
CN1CCC2(CC1)CN(c1cc(C(=O)Nc3cc4cc(-c5cnn(C)c5CO)ccc4cn3)ccn1)C2 CHEMBL4762392 EC50 44.0 nM
Oc1cncc(-c2ccc3[nH]nc(-c4nc5c(-c6cccc(F)c6)ccnc5[nH]4)c3c2)c1 CHEMBL4747400 EC50 45.0 nM
O=C(Nc1cnccn1)c1n[nH]c2ccc(-c3cncc(CN4CCCCC4)c3)cc12 CHEMBL4743856 EC50 46.0 nM
CCC(=O)Nc1cncc(-c2ccc3[nH]nc(-c4cc5c(-c6cccc(F)c6)nccc5[nH]4)c3c2)c1 CHEMBL4796957 EC50 46.0 nM
O=C(Nc1cncc(-c2cnc3[nH]nc(-c4cc5cnccc5[nH]4)c3c2)c1)c1ccccc1 CHEMBL4751252 EC50 46.0 nM
O=C(Nc1cccnc1)c1n[nH]c2ccc(-c3cncc(NC(=O)N4CCOCC4)c3)cc12 CHEMBL4790121 EC50 47.0 nM
O=C(Nc1ccc(CN2CCCC2)cc1)c1n[nH]c2ccc(-c3cccnc3F)cc12 CHEMBL4790477 EC50 47.0 nM
O=C(Nc1cncc(-c2cnc3[nH]nc(-c4cc5c(-c6ccccc6F)nccc5[nH]4)c3c2)c1)C1CC1 CHEMBL4745228 EC50 47.0 nM
CC(C)(C)CC(=O)Nc1cncc(-c2cnc3[nH]nc(-c4cc5cnccc5[nH]4)c3c2)c1 CHEMBL4752468 EC50 47.0 nM
CN1CCC(Oc2ccc(NC(=O)c3n[nH]c4cc(F)c(-c5cnn(C)c5)cc34)cn2)CC1 CHEMBL4751049 EC50 48.0 nM
Cc1ncc(NC(=O)c2n[nH]c3ccc(-c4cnn(C5CCN(C)CC5)c4)cc23)s1 CHEMBL4777667 EC50 48.0 nM
Fc1cccc(-c2cncc3[nH]c(-c4n[nH]c5ncc(-c6cccnc6)cc45)nc23)c1 CHEMBL4778616 EC50 48.0 nM
CCCC(=O)Nc1cncc(-c2ccc3[nH]nc(-c4nc5c(-c6ccsc6)cncc5[nH]4)c3n2)c1 CHEMBL4760441 EC50 48.0 nM
O=C(CC1CCNCC1)Nc1cncc(-c2ccc3[nH]nc(-c4cc5c(N6CCCCC6)nccc5[nH]4)c3n2)c1 CHEMBL4795946 EC50 48.0 nM
CC(C)CC(=O)Nc1cncc(-c2cnc3[nH]nc(-c4cc5c(-c6cc(F)cc(CNS(C)(=O)=O)c6)nccc5[nH]4)c3c2)c1 CHEMBL4764899 EC50 48.0 nM
CN1CCc2cc(C(=O)Nc3cc4cc(-c5cn(C)nn5)ccc4cn3)ccc2C1 CHEMBL4777663 EC50 48.0 nM
CN1CCC(Oc2ccc(NC(=O)c3n[nH]c4ccc(-c5ccc(N)nc5)cc34)cc2)CC1 CHEMBL4788156 EC50 49.0 nM
O=C(Nc1cncc(-c2cnc3[nH]nc(-c4nc5c(-c6cccnc6)cncc5[nH]4)c3c2)c1)C1CCC1 CHEMBL4755315 EC50 49.0 nM
CCNCc1cncc(-c2ccc3[nH]nc(-c4cc5cnccc5[nH]4)c3c2)c1 CHEMBL4753378 EC50 49.0 nM
CN(C)CCNc1cc(F)cc(-c2cccc3[nH]c(-c4n[nH]c5cnc(-c6cncc(NC(=O)C(C)(C)C)c6)cc45)cc23)c1 CHEMBL4793616 EC50 49.0 nM
CN(C)CCNc1cc(F)cc(-c2cccc3[nH]c(-c4n[nH]c5ccc(-c6cncc(CN7CCCCC7)c6)nc45)cc23)c1 CHEMBL4780639 EC50 49.0 nM
Cn1cc(-c2ccc3cnc(NC(=O)c4ccc5c(cnn5C)c4)cc3c2)cn1 CHEMBL4752070 EC50 49.0 nM
CO[C@@H]1CCC[C@H]1NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5408907 IC50 49.0 nM
Nc1cncc(-c2ccc3[nH]nc(-c4nc5c(-c6ccccc6F)nccc5[nH]4)c3n2)c1 CHEMBL4763852 EC50 50.0 nM
CC(C)Nc1cncc(-c2ccc3[nH]nc(-c4nc5c(-c6cc(F)cc(NCCN(C)C)c6)nccc5[nH]4)c3c2)c1 CHEMBL4760437 EC50 50.0 nM
Nc1cncc(-c2cnc3[nH]nc(-c4cc5c(-c6ccncc6)nccc5[nH]4)c3c2)c1 CHEMBL4757102 EC50 50.0 nM
CN(C)CCNc1cc(F)cc(-c2cccc3[nH]c(-c4n[nH]c5cnc(-c6cncc(N)c6)cc45)cc23)c1 CHEMBL4759727 EC50 50.0 nM
CN1CCN(c2cncc3[nH]c(-c4n[nH]c5ccc(-c6cccnc6)cc45)nc23)CC1 CHEMBL4751115 EC50 51.0 nM
CCNCc1cncc(-c2cnc3[nH]nc(-c4cc5c(-c6cc(F)cc(CNS(C)(=O)=O)c6)cncc5[nH]4)c3c2)c1 CHEMBL4788404 EC50 51.0 nM
Cc1ccc(-c2nccc3[nH]c(-c4n[nH]c5ccc(-c6cncc(N)c6)cc45)nc23)s1 CHEMBL4753494 EC50 52.0 nM
CCC(=O)Nc1cncc(-c2ccc3[nH]nc(-c4cc5c(N6CCCCC6)nccc5[nH]4)c3c2)c1 CHEMBL4776104 EC50 52.0 nM
CCNCc1cncc(-c2ccc3[nH]nc(-c4cc5c(-c6cc(F)cc(CNS(C)(=O)=O)c6)cncc5[nH]4)c3c2)c1 CHEMBL4743076 EC50 52.0 nM
CC(C)Nc1cncc(-c2ccc3cnc(NC(=O)C4CCN(CCF)CC4)cc3c2)n1 CHEMBL4751376 EC50 52.0 nM
c1cc2[nH]c(-c3n[nH]c4ncc(-c5cncc(CN6CCCCC6)c5)cc34)cc2cn1 CHEMBL4789272 EC50 53.0 nM
CS(=O)(=O)NCc1cc(F)cc(-c2cncc3[nH]c(-c4n[nH]c5ncc(-c6cncc(CN7CCCCC7)c6)cc45)cc23)c1 CHEMBL4755835 EC50 53.0 nM
O=C(Nc1cc2cc(-c3cncc(NCC4(F)CNC4)n3)ncc2cn1)C1CC1 CHEMBL4741309 EC50 53.0 nM
CO[C@H]1CCC[C@@H]1NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5427842 IC50 53.0 nM
O=C(Nc1cncc(-c2ccc3[nH]nc(-c4nc5c(N6CCCCC6)cncc5[nH]4)c3c2)c1)C1CCC1 CHEMBL4752631 EC50 54.0 nM
Cc1ccncc1-c1cc2c(-c3nc4c(-c5cc(F)cc(CNS(C)(=O)=O)c5)ccnc4[nH]3)n[nH]c2cn1 CHEMBL4797300 EC50 54.0 nM
CCCCC(=O)Nc1cncc(-c2cc3c(-c4cc5cnccc5[nH]4)n[nH]c3cn2)c1 CHEMBL4746788 EC50 54.0 nM
CN1CCC(n2cc(NC(=O)c3n[nH]c4ccc(-c5cnn(C)c5)cc34)cn2)CC1 CHEMBL4796085 EC50 55.0 nM
CN(C)CCOc1cncc(-c2cnc3[nH]nc(-c4nc5c(-c6cccc(F)c6)nccc5[nH]4)c3c2)c1 CHEMBL4755870 EC50 55.0 nM
COc1cccc(-c2cncc3[nH]c(-c4n[nH]c5ccc(-c6cccnc6)nc45)nc23)c1 CHEMBL4783753 EC50 55.0 nM
CC(C)CC(=O)Nc1cncc(-c2ccc3[nH]nc(-c4nc5cncc(-c6cccc(F)c6)c5[nH]4)c3c2)c1 CHEMBL4297639 EC50 56.0 nM
Cc1cn(-c2nccc3[nH]c(-c4n[nH]c5ccc(-c6cncc(NC(=O)CC(C)C)c6)cc45)nc23)cn1 CHEMBL4740717 EC50 56.0 nM
CN(C)Cc1cncc(-c2ccc3[nH]nc(-c4cc5c(-c6ccncc6)cncc5[nH]4)c3c2)c1 CHEMBL4780076 EC50 56.0 nM
CC(C)(C)CC(=O)Nc1cncc(-c2cc3c(-c4cc5cnccc5[nH]4)n[nH]c3cn2)c1 CHEMBL4746032 EC50 56.0 nM
CNC(=O)c1ccc(C(=O)Nc2cc3cc(-c4cn(C)nn4)ccc3cn2)cn1 CHEMBL4790614 EC50 56.0 nM
CC(C)CC(=O)Nc1cncc(-c2cnc3[nH]nc(-c4nc5c(-c6cccc(F)c6)cncc5[nH]4)c3c2)c1 CHEMBL4757954 EC50 57.0 nM
CCCC(=O)Nc1cncc(-c2ccc3[nH]nc(-c4nc5c(N6CCCCC6)cncc5[nH]4)c3c2)c1 CHEMBL4762565 EC50 58.0 nM
CS(=O)(=O)NCc1cc(F)cc(-c2cncc3[nH]c(-c4n[nH]c5ccc(-c6cncnc6)nc45)cc23)c1 CHEMBL4765107 EC50 58.0 nM
Nc1cncc(-c2cc3c(-c4cc5c(-c6ccccc6F)nccc5[nH]4)n[nH]c3cn2)c1 CHEMBL4780582 EC50 59.0 nM
CS(=O)(=O)NCc1cc(F)cc(-c2nccc3[nH]c(-c4n[nH]c5ncc(-c6cncc(NC(=O)C7CCC7)c6)cc45)cc23)c1 CHEMBL4754966 EC50 59.0 nM
O=C(Nc1cc2cc(-c3cncc(NC4CCNCC4)n3)ccc2cn1)C1CCCCC1 CHEMBL4763112 EC50 59.0 nM
O=C(Nc1ccc2c(c1)OCCO2)c1n[nH]c2ccc(-c3cncc(CN4CCCCC4)c3)cc12 CHEMBL4758259 EC50 60.0 nM
CC(C)CC(=O)Nc1cncc(-c2ccc3[nH]nc(-c4nc5c(-c6cc(F)cc(CNS(C)(=O)=O)c6)cncc5[nH]4)c3c2)c1 CHEMBL4793420 EC50 60.0 nM
O=C(Nc1cncc(-c2cnc3[nH]nc(-c4cc5c(-c6cccs6)nccc5[nH]4)c3c2)c1)C1CCC1 CHEMBL4754927 EC50 60.0 nM
CN(C)CCNc1cc(C(=O)Nc2cc3cc(-c4cnn(C)c4)ccc3cn2)ccn1 CHEMBL4755182 EC50 60.0 nM
CN1CCN(c2cc(C(=O)Nc3cc4nc(-c5cnn(C)c5)ccc4cn3)ccn2)CC1 CHEMBL4743920 EC50 60.0 nM
CCC(=O)Nc1cncc(-c2ccc3[nH]nc(-c4nc5c(-c6cccc(F)c6)cncc5[nH]4)c3c2)c1 CHEMBL4750399 EC50 61.0 nM
c1cncc(-c2ccc3[nH]nc(-c4nc5c(N6CCOCC6)cncc5[nH]4)c3c2)c1 CHEMBL4782737 EC50 61.0 nM
Cc1ccncc1-c1cc2c(-c3cc4cnccc4[nH]3)n[nH]c2cn1 CHEMBL4799353 EC50 61.0 nM
CC(C)OC(=O)N1CCC(n2cc(C(=O)Nc3cc4cc(-c5cnn(C)c5)ncc4cn3)cn2)CC1 CHEMBL4790835 EC50 61.0 nM
O=C(Nc1cccnc1)c1n[nH]c2ccc(-c3cncc(CN4CC(CO)(CO)C4)c3)cc12 CHEMBL4780576 EC50 62.0 nM
CCC(=O)Nc1cncc(-c2cnc3[nH]nc(-c4nc5c(-c6ccsc6)cccc5[nH]4)c3c2)c1 CHEMBL4779032 EC50 62.0 nM
CCC(=O)Nc1cncc(-c2cnc3[nH]nc(-c4nc5c(-c6cccs6)cncc5[nH]4)c3c2)c1 CHEMBL4744433 EC50 62.0 nM
CC(C)CC(=O)Nc1cncc(-c2ccc3[nH]nc(-c4nc5c(-c6cccs6)cncc5[nH]4)c3c2)c1 CHEMBL4746968 EC50 62.0 nM
CC(C)(C)C(=O)Nc1cncc(-c2cnc3[nH]nc(-c4cc5c(-c6ccncc6)cncc5[nH]4)c3c2)c1 CHEMBL4763649 EC50 62.0 nM
O=C(Nc1cncc(-c2cc3c(-c4cc5cnccc5[nH]4)n[nH]c3cn2)c1)C1CCCCC1 CHEMBL4756871 EC50 62.0 nM
O=C(Nc1cncc(-c2cc3c(-c4cc5cnccc5[nH]4)n[nH]c3cn2)c1)c1ccccc1 CHEMBL4758596 EC50 62.0 nM
Nc1cncc(-c2ccc3[nH]nc(-c4cc5c(-c6ccncc6)ccnc5[nH]4)c3n2)c1 CHEMBL4744766 EC50 63.0 nM
CN(C)CCNc1cc(F)cc(-c2cccc3[nH]c(-c4n[nH]c5ccc(-c6cncnc6)nc45)cc23)c1 CHEMBL4756681 EC50 63.0 nM
CCC(=O)Nc1cncc(-c2ccc3[nH]nc(-c4nc5c(-c6ccsc6)cncc5[nH]4)c3c2)c1 CHEMBL4783817 EC50 64.0 nM
c1ncc(-c2ccc3[nH]nc(-c4cc5c(N6CCCCC6)cncc5[nH]4)c3c2)cc1CN1CCCC1 CHEMBL4798538 EC50 64.0 nM
COc1cncc(-c2ccc3[nH]nc(-c4nc5c(-c6cccc(F)c6)cncc5[nH]4)c3n2)c1 CHEMBL4788759 EC50 65.0 nM
CC(C)(C)CC(=O)Nc1cncc(-c2ccc3[nH]nc(-c4nc5ccncc5[nH]4)c3c2)c1 CHEMBL4783807 EC50 65.0 nM
O=C(CC1CCNCC1)Nc1cncc(-c2ccc3[nH]nc(-c4nc5c(-c6ccsc6)nccc5[nH]4)c3n2)c1 CHEMBL4747934 EC50 66.0 nM
Nc1cncc(-c2cnc3[nH]nc(-c4cc5c(-c6ccccc6F)ccnc5[nH]4)c3c2)c1 CHEMBL4756589 EC50 66.0 nM
CS(=O)(=O)NCc1cc(F)cc(-c2cncc3[nH]c(-c4n[nH]c5ccc(-c6cncc(NC(=O)C7CCC7)c6)cc45)cc23)c1 CHEMBL4785853 EC50 66.0 nM
Cn1cc(-c2ccc3cnc(NC(=O)c4cnc5ccccc5c4)cc3c2)cn1 CHEMBL4780800 EC50 66.0 nM
CN(C)Cc1cncc(-c2cnc3[nH]nc(-c4nc5c(-c6ccsc6)cccc5[nH]4)c3c2)c1 CHEMBL4764778 EC50 67.0 nM
CC(C)CC(=O)Nc1cncc(-c2ccc3[nH]nc(-c4nc5c(-c6ccc(Cl)s6)cncc5[nH]4)c3n2)c1 CHEMBL4748599 EC50 67.0 nM
Nc1cncc(-c2cnc3[nH]nc(-c4cc5c(-c6ccccc6F)nccc5[nH]4)c3c2)c1 CHEMBL4760948 EC50 67.0 nM
c1cc2cc(-c3n[nH]c4ccc(-c5cncc(OCCN6CCCC6)c5)cc34)[nH]c2cn1 CHEMBL4749742 EC50 68.0 nM
c1ccc(CNCc2cncc(-c3ccc4[nH]nc(-c5cc6c(-c7cccs7)cncc6[nH]5)c4c3)c2)cc1 CHEMBL4743209 EC50 68.0 nM
c1cncc(-c2ccnc3[nH]c(-c4n[nH]c5ncc(-c6cncc(CN7CCCCC7)c6)cc45)cc23)c1 CHEMBL4747481 EC50 69.0 nM
Nc1cncc(-c2cnc3[nH]nc(-c4cc5c(-c6ccncc6)cncc5[nH]4)c3c2)c1 CHEMBL4741393 EC50 69.0 nM
O=C(Nc1cncc(-c2cnc3[nH]nc(-c4cc5c(-c6ccncc6)cncc5[nH]4)c3c2)c1)C1CCC1 CHEMBL4750354 EC50 69.0 nM
Cc1ncc(-c2ccc3cnc(NC(=O)c4ccc(OC(C)C)cc4)cc3c2)n1C CHEMBL4791186 EC50 70.0 nM
O=C(Nc1ccc(-c2ccccc2)nc1)c1n[nH]c2ccc(-c3cncc(CN4CCCCC4)c3)cc12 CHEMBL4743940 EC50 71.0 nM
O=C(Nc1cncc(-c2ccc3[nH]nc(-c4cc5c(-c6cccnc6)cncc5[nH]4)c3c2)c1)c1ccccc1 CHEMBL4786950 EC50 71.0 nM
CN1CCN(c2cc(C(=O)Nc3cc4cc(-c5cnn(C6CC6)c5)ccc4cn3)ccn2)CC1 CHEMBL4750631 EC50 71.0 nM
O=C(Nc1ccc(OC(CO)CO)nc1)c1n[nH]c2ccc(-c3cncc(CN4CCCCC4)c3)cc12 CHEMBL4752327 EC50 73.0 nM
Nc1cncc(-c2ccc3[nH]nc(-c4cc5cccnc5[nH]4)c3c2)c1 CHEMBL4755073 EC50 73.0 nM
CO[C@H]1CCC[C@H](NC2=N/C(=C\c3ccc4ncsc4c3)C(=O)N2)C1 CHEMBL5436754 IC50 73.0 nM
Oc1cncc(-c2ccc3[nH]nc(-c4nc5c(-c6cccc(F)c6)cncc5[nH]4)c3n2)c1 CHEMBL4753319 EC50 74.0 nM
CN(C)Cc1cncc(-c2cnc3[nH]nc(-c4cc5c(-c6cccc(F)c6)nccc5[nH]4)c3c2)c1 CHEMBL4755078 EC50 74.0 nM
CCNCc1cncc(-c2cnc3[nH]nc(-c4cc5c(-c6cccnc6)ccnc5[nH]4)c3c2)c1 CHEMBL4758482 EC50 74.0 nM
CC(C)CC(=O)Nc1cncc(-c2ccc3[nH]nc(-c4nc5c(-c6ccc(F)cc6)cncc5[nH]4)c3c2)c1 CHEMBL4789715 EC50 75.0 nM
CC(C)C(=O)Nc1cncc(-c2cc3c(-c4cc5c(-c6cc(F)cc(CNS(C)(=O)=O)c6)nccc5[nH]4)n[nH]c3cn2)c1 CHEMBL4762665 EC50 75.0 nM
CCNCc1cncc(-c2cnc3[nH]nc(-c4nc5c(-c6cccc(F)c6)cccc5[nH]4)c3c2)c1 CHEMBL4743067 EC50 76.0 nM
Nc1cncc(-c2cnc3[nH]nc(-c4nc5c(-c6ccccc6F)ccnc5[nH]4)c3c2)c1 CHEMBL4795951 EC50 76.0 nM
Cc1ccncc1-c1ccc2[nH]nc(-c3nc4c(-c5ccsc5)nccc4[nH]3)c2c1 CHEMBL4797672 EC50 76.0 nM
O=C(Nc1cncc(-c2ccc3[nH]nc(-c4cc5c(-c6cccnc6)cncc5[nH]4)c3c2)c1)C1CCCC1 CHEMBL4755941 EC50 78.0 nM
CN1CCN(c2cc(CC(=O)Nc3cc4cc(-c5cnn(C)c5)ccc4cn3)ccn2)CC1 CHEMBL4759886 EC50 78.0 nM
O=C(Nc1cc2cc(-c3cncc(NC4CCNCC4)n3)ccc2cn1)C1CC(F)(F)C1 CHEMBL4761487 EC50 78.0 nM
CN1CCC(Nc2ccc(NC(=O)c3n[nH]c4cc(F)c(-c5cnn(C)c5)cc34)cn2)CC1 CHEMBL4794020 EC50 79.0 nM
CN(C)Cc1cncc(-c2ccc3[nH]nc(-c4nc5c(-c6cccc(F)c6)cncc5[nH]4)c3n2)c1 CHEMBL4757172 EC50 79.0 nM
CCCCC(=O)Nc1cncc(-c2ccc3[nH]nc(-c4nc5c(-c6cc(F)cc(NCCN(C)C)c6)ccnc5[nH]4)c3n2)c1 CHEMBL4761965 EC50 79.0 nM
CS(=O)(=O)NCc1cc(F)cc(-c2nccc3[nH]c(-c4n[nH]c5ccc(-c6cncc(CN7CCCCC7)c6)nc45)cc23)c1 CHEMBL4782289 EC50 79.0 nM
CN1CCN(c2ccc(NC(=O)c3n[nH]c4ccc(-c5cncc(NC(=O)c6c(F)cccc6F)c5)cc34)cn2)CC1 CHEMBL4745311 EC50 81.0 nM
CC(C)CC(=O)Nc1cncc(-c2cnc3[nH]nc(-c4cc5c(-c6cc(F)cc(CNS(C)(=O)=O)c6)cncc5[nH]4)c3c2)c1 CHEMBL4744478 EC50 81.0 nM
CN1CCN(c2ccc(C(=O)Nc3cc4cc(-c5cnn6c5CN(CCF)CC6)ccc4cn3)cn2)CC1 CHEMBL4747563 EC50 81.0 nM
CCNCc1cncc(-c2ccc3[nH]nc(-c4nc5c(-c6cc(F)cc(NCCN(C)C)c6)ccnc5[nH]4)c3n2)c1 CHEMBL4798951 EC50 82.0 nM
Cc1ncc(-c2ccc3[nH]nc(-c4nc5c(-c6cccc(F)c6)cccc5[nH]4)c3n2)n1C CHEMBL4752659 EC50 83.0 nM
CN(C)c1cncc(-c2ccc3[nH]nc(-c4nc5c(-c6cccs6)cncc5[nH]4)c3n2)c1 CHEMBL4742246 EC50 83.0 nM
CN(C)Cc1cncc(-c2ccc3[nH]nc(-c4cc5c(-c6cccc(F)c6)nccc5[nH]4)c3c2)c1 CHEMBL4757524 EC50 83.0 nM
CCCCC(=O)Nc1cncc(-c2cnc3[nH]nc(-c4cc5cnccc5[nH]4)c3c2)c1 CHEMBL4751155 EC50 83.0 nM
Cc1n[nH]c2ccc(-c3cncc(OC[C@@H](N)Cc4ccccc4)c3)cc12 CHEMBL379218 EC50 84.0 nM
COc1cccc(-c2ccnc3[nH]c(-c4n[nH]c5ccc(-c6cccnc6)nc45)nc23)c1 CHEMBL4788493 EC50 84.0 nM
CCC(=O)Nc1cncc(-c2ccc3[nH]nc(-c4cc5c(-c6cccc(F)c6)cncc5[nH]4)c3c2)c1 CHEMBL4796795 EC50 85.0 nM
CC(C)(C)CC(=O)Nc1cncc(-c2cnc3[nH]nc(-c4cc5c(-c6cccnc6)cncc5[nH]4)c3c2)c1 CHEMBL4744328 EC50 85.0 nM
c1cnc2[nH]c(-c3n[nH]c4ccc(-c5cncc(CN6CCCCC6)c5)cc34)cc2c1 CHEMBL4777829 EC50 85.0 nM
Cn1cc(-c2ccc3cnc(NC(=O)c4ccc5cnccc5c4)cc3c2)cn1 CHEMBL4758126 EC50 85.0 nM
CC1CCN(Cc2cncc(-c3ccc4[nH]nc(C(=O)Nc5cccnc5)c4c3)c2)CC1 CHEMBL4785547 EC50 86.0 nM
O=C1NC(=S)S/C1=C\c1ccc2ncccc2c1 CHEMBL3774448 IC50 86.6 nM
O=C(Nc1cncc(-c2ccc3[nH]nc(-c4nc5c(-c6ccc(F)cc6)cncc5[nH]4)c3c2)c1)C1CCC1 CHEMBL4747931 EC50 87.0 nM
CCCC(=O)Nc1cncc(-c2cnc3[nH]nc(-c4nc5c(-c6ccoc6)cccc5[nH]4)c3c2)c1 CHEMBL4750787 EC50 87.0 nM
CC(C)Nc1cncc(-c2ccc3[nH]nc(-c4nc5c(-c6ccoc6)cncc5[nH]4)c3n2)c1 CHEMBL4795987 EC50 87.0 nM
CC(C)Oc1ccc(NC(=O)c2n[nH]c3ccc(-c4cncc(CN5CC6CC(C5)O6)c4)cc23)cn1 CHEMBL4743194 EC50 88.0 nM
Clc1ccc(-c2cncc3[nH]c(-c4n[nH]c5ccc(-c6cncc(CN7CCCC7)c6)nc45)nc23)s1 CHEMBL4758045 EC50 88.0 nM
c1cncc(-c2cc3c(-c4cc5cnccc5[nH]4)n[nH]c3cn2)c1 CHEMBL4747558 EC50 88.0 nM
O=C(Nc1cncc(-c2cc3c(-c4cc5cnccc5[nH]4)n[nH]c3cn2)c1)C1CC1 CHEMBL4757454 EC50 88.0 nM
C[C@@H]1CN(c2ccc(NC(=O)c3n[nH]c4ccc(-c5cncc(CN6CCCCC6)c5)cc34)cn2)C[C@H](C)O1 CHEMBL4794727 EC50 89.0 nM
CN1CCC(Oc2ncc(NC(=O)c3n[nH]c4cc(F)c(-c5cnn(C)c5)cc34)cc2F)CC1 CHEMBL4778878 EC50 89.0 nM
COc1cncc(-c2ccc3[nH]nc(-c4nc5c(-c6cccc(F)c6)ccnc5[nH]4)c3n2)c1 CHEMBL4747036 EC50 89.0 nM
FC1(F)CCN(Cc2cncc(-c3cc4c(-c5nc6c(N7CCCCC7)cncc6[nH]5)n[nH]c4cn3)c2)C1 CHEMBL4761624 EC50 89.0 nM
CCNCc1cncc(-c2cnc3[nH]nc(-c4cc5c(-c6ccccc6F)cncc5[nH]4)c3c2)c1 CHEMBL4760804 EC50 89.0 nM
CN1CCN(c2ccnc3[nH]c(-c4n[nH]c5ccc(-c6cncc(N)c6)cc45)cc23)CC1 CHEMBL4744948 EC50 89.0 nM
Cn1cc(-c2cc3c(C(=O)Nc4ccc(CN5CCCC5)cc4)n[nH]c3cc2F)cn1 CHEMBL4741843 EC50 90.0 nM
Fc1cccc(-c2ccnc3[nH]c(-c4n[nH]c5ccc(-c6cncc(CN7CCC(F)(F)C7)c6)cc45)nc23)c1 CHEMBL4798488 EC50 90.0 nM
CCNCc1cncc(-c2ccc3[nH]nc(-c4nc5c(-c6cc(F)cc(NCCN(C)C)c6)nccc5[nH]4)c3n2)c1 CHEMBL4750400 EC50 90.0 nM
c1cncc(-c2ccc3[nH]nc(-c4cc5c(-c6cccnc6)ccnc5[nH]4)c3c2)c1 CHEMBL4778916 EC50 90.0 nM
O=C1NC(NC23CC4(F)CC(F)(CC(F)(C4)C2)C3)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5422486 IC50 90.0 nM
CC(C)(C)C(=O)Nc1cncc(-c2ccc3[nH]nc(-c4nc5c(-c6ccc(Cl)s6)cncc5[nH]4)c3n2)c1 CHEMBL4749262 EC50 91.0 nM
CC(C)(C)C(=O)Nc1cncc(-c2cc3c(-c4cc5c(-c6ccncc6)cncc5[nH]4)n[nH]c3cn2)c1 CHEMBL4743111 EC50 92.0 nM
O=C1N=C(Nc2c(Cl)cccc2Cl)S/C1=C\c1ccc2nccnc2c1 CHEMBL5081787 IC50 92.6 nM
O=C(Nc1ccnc(C(F)(F)F)c1)c1n[nH]c2ccc(-c3cncc(CN4CCCCC4)c3)cc12 CHEMBL4744530 EC50 93.0 nM
Oc1cncc(-c2ccc3[nH]nc(-c4nc5c(-c6cccc(F)c6)nccc5[nH]4)c3n2)c1 CHEMBL4743122 EC50 93.0 nM
Fc1cccc(-c2ccnc3[nH]c(-c4n[nH]c5ncc(-c6cn[nH]c6)cc45)nc23)c1 CHEMBL4785555 EC50 93.0 nM
CCCCC(=O)Nc1cncc(-c2ccc3[nH]nc(-c4nc5c(-c6cc(F)cc(NCCN(C)C)c6)cncc5[nH]4)c3n2)c1 CHEMBL4759161 EC50 93.0 nM
CC(C)(C)C(=O)Nc1cncc(-c2ccc3[nH]nc(-c4nc5c(N6CCCCC6)cncc5[nH]4)c3c2)c1 CHEMBL4784341 EC50 94.0 nM
Nc1cncc(-c2cc3c(-c4cc5c(N6CCCCC6)cncc5[nH]4)n[nH]c3cn2)c1 CHEMBL4763741 EC50 94.0 nM
CCCC(=O)Nc1cncc(-c2cc3c(-c4cc5c(-c6cc(F)cc(NCCN(C)C)c6)ccnc5[nH]4)n[nH]c3cn2)c1 CHEMBL4763521 EC50 94.0 nM
O=C(Nc1cc2cc(-c3cncc(CN4CCC(O)CC4)c3)ccc2cn1)c1ccc(F)cc1 CHEMBL4781707 EC50 94.0 nM
COc1cccc(-c2nccc3[nH]c(-c4n[nH]c5ccc(-c6cccnc6)nc45)nc23)c1 CHEMBL4782795 EC50 96.0 nM
O=C1NC(NC2CCCCC(F)(F)C2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5396550 IC50 96.0 nM
CC(C)n1cc(C(=O)Nc2cc3cc(-c4cncc(NC5CCN(C)CC5)n4)ncc3cn2)cn1 CHEMBL4785775 EC50 97.0 nM
Cc1ncc(NC(=O)c2n[nH]c3ccc(-c4cnc(C)n4C)cc23)s1 CHEMBL4756183 EC50 99.0 nM
Fc1ccccc1-c1cncc2[nH]c(-c3n[nH]c4ncc(-c5cn[nH]c5)cc34)cc12 CHEMBL4763957 EC50 99.0 nM
Cn1cc(-c2ccc3[nH]nc(-c4cc5c(-c6cccnc6)cncc5[nH]4)c3c2)cn1 CHEMBL4746411 EC50 100.0 nM
CCCC(=O)Nc1cncc(-c2cnc3[nH]nc(-c4cc5c(-c6ccncc6)ccnc5[nH]4)c3c2)c1 CHEMBL4783896 EC50 100.0 nM
Cn1cc(-c2cc3c(C(=O)Nc4ccc(OCCN5CCCC5)cc4)n[nH]c3cc2F)cn1 CHEMBL4756656 EC50 101.0 nM
FC1(F)CCN(Cc2cncc(-c3ccc4[nH]nc(-c5cc6c(-c7cccnc7)ccnc6[nH]5)c4c3)c2)C1 CHEMBL4760685 EC50 101.0 nM
CN(C)Cc1cncc(-c2ccc3[nH]nc(-c4cc5cnccc5[nH]4)c3n2)c1 CHEMBL4796832 EC50 101.0 nM
CN(C)Cc1cncc(-c2ccc3[nH]nc(-c4cc5c(-c6cccnc6)cccc5[nH]4)c3n2)c1 CHEMBL4743788 EC50 102.0 nM
c1cncc(-c2ccnc3[nH]c(-c4n[nH]c5cnc(-c6cncc(CN7CCCC7)c6)cc45)cc23)c1 CHEMBL4757688 EC50 102.0 nM
FC1(F)CCN(Cc2cncc(-c3cnc4[nH]nc(-c5cc6c(-c7ccoc7)cccc6[nH]5)c4c3)c2)C1 CHEMBL4760076 EC50 104.0 nM
CC(C)(C)C(=O)Nc1cncc(-c2ccc3[nH]nc(-c4nc5c(-c6ccc(F)cc6)cncc5[nH]4)c3c2)c1 CHEMBL4789284 EC50 105.0 nM
c1cncc(-c2ccc3[nH]nc(-c4nc5c(-c6cccnc6)nccc5[nH]4)c3n2)c1 CHEMBL4793989 EC50 105.0 nM
Fc1cccc(-c2nccc3[nH]c(-c4n[nH]c5ccc(-c6cccnc6)nc45)cc23)c1 CHEMBL4765221 EC50 105.0 nM
Cc1cn(-c2ccnc3[nH]c(-c4n[nH]c5ccc(-c6cncc(NC(=O)C7CCC7)c6)nc45)nc23)cn1 CHEMBL4795493 EC50 106.0 nM
FC1(F)CCN(Cc2cncc(-c3ccc4[nH]nc(-c5nc6c(N7CCCCC7)cncc6[nH]5)c4c3)c2)C1 CHEMBL4793999 EC50 107.0 nM
CN(C)Cc1cncc(-c2cnc3[nH]nc(-c4cc5c(-c6ccccc6F)cncc5[nH]4)c3c2)c1 CHEMBL4750038 EC50 107.0 nM
Cc1ccncc1-c1cnc2[nH]nc(-c3cc4c(-c5cccnc5)cncc4[nH]3)c2c1 CHEMBL4798397 EC50 107.0 nM
O=C1NC(NC2CCCSC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5405233 IC50 107.0 nM
COc1ccc(NC(=O)c2n[nH]c3ccc(-c4cncc(CN5CCCC5)c4)cc23)cn1 CHEMBL4799007 EC50 109.0 nM
CN(C)Cc1cncc(-c2ccc3[nH]nc(-c4nc5c(-c6cccc(F)c6)cccc5[nH]4)c3n2)c1 CHEMBL4741100 EC50 109.0 nM
O=C(Nc1cncc(-c2ccc3[nH]nc(-c4cc5c(-c6ccccc6F)nccc5[nH]4)c3n2)c1)C1CC1 CHEMBL4749957 EC50 109.0 nM
CN(C)Cc1cncc(-c2ccc3[nH]nc(-c4cc5c(-c6ccccc6F)cncc5[nH]4)c3n2)c1 CHEMBL4782086 EC50 109.0 nM
CN(C)CCNc1cc(F)cc(-c2cccc3[nH]c(-c4n[nH]c5cnc(-c6cncc(O)c6)cc45)cc23)c1 CHEMBL4791991 EC50 109.0 nM
FC1(F)CCN(Cc2cncc(-c3cnc4[nH]nc(-c5cc6c(-c7ccncc7)cncc6[nH]5)c4c3)c2)C1 CHEMBL4751489 EC50 110.0 nM
Nc1cncc(-c2ccc3[nH]nc(-c4cc5c(N6CCCCC6)ccnc5[nH]4)c3c2)c1 CHEMBL4762016 EC50 110.0 nM
CN1CCN(C(=O)C(C)(C)c2ccc(C(=O)Nc3cn4cc(-c5ccncc5)ccc4n3)cc2)CC1 CHEMBL4531334 IC50 110.0 nM
Oc1cncc(-c2ccc3[nH]nc(-c4nc5c(-c6cccc(F)c6)ccnc5[nH]4)c3n2)c1 CHEMBL4777958 EC50 113.0 nM
CC(C)Nc1cncc(-c2ccc3[nH]nc(-c4nc5c(-c6ccoc6)ccnc5[nH]4)c3n2)c1 CHEMBL4755833 EC50 113.0 nM
Nc1cncc(-c2ccc3[nH]nc(-c4cc5c(-c6ccncc6)nccc5[nH]4)c3c2)c1 CHEMBL4747922 EC50 113.0 nM
O=C1NC(NC23CC4CC(CC2C4)C3)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5400230 IC50 114.0 nM
O=C(Nc1cncc(-c2cc3c(-c4nc5c(-c6cccs6)nccc5[nH]4)n[nH]c3cn2)c1)C1CC1 CHEMBL4777730 EC50 115.0 nM
Cn1cc(-c2cc3c(C(=O)Nc4ccc5c(c4)CNC5)n[nH]c3cc2F)cn1 CHEMBL4744452 EC50 116.0 nM
Cc1cn(-c2nccc3[nH]c(-c4n[nH]c5ccc(-c6cncc(NC(=O)CC(C)C)c6)nc45)nc23)cn1 CHEMBL4777273 EC50 116.0 nM
N=C1NC(=O)/C(=C/c2ccc3c(c2)CCO3)S1 CHEMBL4283751 IC50 116.0 nM
CCCC(=O)Nc1cncc(-c2cnc3[nH]nc(-c4nc5c(-c6ccccc6F)cncc5[nH]4)c3c2)c1 CHEMBL4751675 EC50 117.0 nM
CC(C)(C)CC(=O)Nc1cncc(-c2ccc3[nH]nc(-c4cc5c(-c6ccoc6)ccnc5[nH]4)c3c2)c1 CHEMBL4758657 EC50 117.0 nM
COc1cncc(-c2ccc3[nH]nc(-c4cc5c(-c6ccoc6)nccc5[nH]4)c3c2)c1 CHEMBL4750641 EC50 117.0 nM
CN(C)Cc1cncc(-c2cnc3[nH]nc(-c4nc5c(-c6ccsc6)cncc5[nH]4)c3c2)c1 CHEMBL4788012 EC50 118.0 nM
O=C1NC(N[C@H]2CCCOC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5413726 IC50 119.0 nM
O=C(Cc1ccccc1)Nc1cncc(-c2ccc3[nH]nc(-c4nc5c(-c6ccoc6)cncc5[nH]4)c3c2)c1 CHEMBL4761923 EC50 120.0 nM
Fc1cccc(-c2cncc3[nH]c(-c4n[nH]c5ncc(-c6cccnc6)cc45)cc23)c1 CHEMBL4749607 EC50 122.0 nM
Cc1cn(-c2ccnc3[nH]c(-c4n[nH]c5ccc(-c6cncc(NC(=O)C(C)(C)C)c6)nc45)nc23)cn1 CHEMBL4759166 EC50 123.0 nM
CC#CC(=O)Nc1cc2cc(-c3cnn(C)c3)ccc2cn1 CHEMBL4789335 EC50 123.0 nM
COc1cncc(-c2ccc3[nH]nc(-c4nc5c(-c6cccc(F)c6)nccc5[nH]4)c3n2)c1 CHEMBL4795264 EC50 124.0 nM
O=C1NC(NC2CCCCC2(F)F)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5396991 IC50 127.0 nM
COC[C@H](NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1)c1ccccc1 CHEMBL5439392 IC50 127.0 nM
CN(C)Cc1cncc(-c2cnc3[nH]nc(-c4nc5c(-c6cccs6)cncc5[nH]4)c3c2)c1 CHEMBL4760436 EC50 128.0 nM
CC(C)C(=O)Nc1cncc(-c2ccc3[nH]nc(-c4nc5c(-c6cccnc6)ccnc5[nH]4)c3n2)c1 CHEMBL4786522 EC50 132.0 nM
CC(C)CC(=O)Nc1cncc(-c2ccc3[nH]nc(-c4cc5c(-c6ccncc6)nccc5[nH]4)c3c2)c1 CHEMBL4780519 EC50 132.0 nM
O=C(Nc1ccc(CN2CCCC2)cc1)c1n[nH]c2ccc(-c3cnn(C4CC4)c3)cc12 CHEMBL4744357 EC50 133.0 nM
Cc1ccncc1-c1ccc2[nH]nc(-c3cc4c(-c5cccnc5)cncc4[nH]3)c2n1 CHEMBL4741420 EC50 133.0 nM
O=C(Nc1cc2cc(-c3cncc(NC4CCNCC4)n3)ncc2cn1)C1CCOCC1 CHEMBL4794913 EC50 133.0 nM
CO[C@@H]1CCCCC[C@H]1NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5428629 IC50 133.0 nM
CC(C)Nc1cncc(-c2cnc3[nH]nc(-c4nc5c(-c6ccoc6)nccc5[nH]4)c3c2)c1 CHEMBL4776491 EC50 134.0 nM
O=C(Nc1cnccn1)c1n[nH]c2ccc(-c3cncc(CN4CCCCCC4)c3)cc12 CHEMBL4747741 EC50 135.0 nM
CN1CCN(c2cc(C(=O)Nc3ncc4ccc(-c5cnn(C)c5)cc4n3)ccn2)CC1 CHEMBL4778580 EC50 135.0 nM
O=C1NC(NCc2ccccc2C(F)(F)F)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5430415 IC50 135.0 nM
CCNCc1cncc(-c2ccc3[nH]nc(-c4nc5c(-c6ccccn6)nccc5[nH]4)c3c2)c1 CHEMBL4744253 EC50 136.0 nM
CC(C)(C)C(=O)Nc1cncc(-c2ccc3[nH]nc(-c4cc5c(-c6ccncc6)ccnc5[nH]4)c3c2)c1 CHEMBL4743802 EC50 137.0 nM
CN1CCN(c2nccc3[nH]c(-c4n[nH]c5cnc(-c6cncc(NC(=O)C(C)(C)C)c6)cc45)cc23)CC1 CHEMBL4757534 EC50 137.0 nM
Cn1cc(-c2cnc3[nH]nc(-c4nc5c(-c6cccc(F)c6)nccc5[nH]4)c3c2)cn1 CHEMBL4753975 EC50 138.0 nM
CCC(=O)Nc1cncc(-c2cc3c(-c4cc5c(-c6cccc(F)c6)nccc5[nH]4)n[nH]c3cn2)c1 CHEMBL4780543 EC50 138.0 nM
O=C1NC(N[C@@H]2CCCCC[C@H]2O)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5439952 IC50 138.0 nM
O=C(Nc1ccc(N2CCCC2)nc1)c1n[nH]c2ccc(-c3cncc(CN4CCC4)c3)cc12 CHEMBL4800437 EC50 139.0 nM
Fc1ccc(-c2nccc3[nH]c(-c4n[nH]c5ccc(-c6cncc(CN7CCCC7)c6)cc45)cc23)cc1 CHEMBL4779789 EC50 139.0 nM
CC(C)Nc1cncc(-c2ccc3[nH]nc(-c4cc5c(-c6cccnc6)ccnc5[nH]4)c3n2)c1 CHEMBL4784177 EC50 139.0 nM
c1csc(-c2nccc3[nH]c(-c4n[nH]c5cnc(-c6cncc(CN7CCCCC7)c6)cc45)cc23)c1 CHEMBL4741555 EC50 140.0 nM
CS(=O)(=O)NCc1cc(F)cc(-c2cncc3[nH]c(-c4n[nH]c5ccc(-c6cncc(NC(=O)C7CC7)c6)nc45)cc23)c1 CHEMBL4795292 EC50 140.0 nM
Cn1cc(-c2ccc3cnc(NC(=O)c4ccc5nccnc5c4)cc3n2)cn1 CHEMBL4794127 EC50 141.0 nM
FC1(F)CCN(Cc2cncc(-c3ccc4[nH]nc(-c5cc6c(-c7ccccn7)cccc6[nH]5)c4n3)c2)C1 CHEMBL4747611 EC50 142.0 nM
CN1CCN(c2cncc3[nH]c(-c4n[nH]c5ccc(-c6cncc(CNCc7ccccc7)c6)cc45)cc23)CC1 CHEMBL4785840 EC50 142.0 nM
CC(C)(C)C(=O)Nc1cncc(-c2cnc3[nH]nc(-c4nc5c(-c6ccoc6)cncc5[nH]4)c3c2)c1 CHEMBL4792061 EC50 143.0 nM
Cn1ncc(-c2ccc3cnc(NC(=O)[C@H]4CC[C@H](CO)CC4)cc3c2)c1CN1CCCCC1 CHEMBL4752464 EC50 143.0 nM
O=C1NC(NC2CC3CCC2C3)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5412998 IC50 143.0 nM
CC(C)CC(=O)Nc1cncc(-c2ccc3[nH]nc(-c4cc5c(-c6ccccc6F)nccc5[nH]4)c3n2)c1 CHEMBL4800107 EC50 144.0 nM
O=C(Nc1cncc(-c2ccc3[nH]nc(-c4nc5c(-c6ccc(Cl)s6)cncc5[nH]4)c3n2)c1)C1CCC1 CHEMBL4798360 EC50 145.0 nM
CN1CCN(c2cncc3[nH]c(-c4n[nH]c5ccc(-c6cncc(NC(=O)CC(C)(C)C)c6)cc45)cc23)CC1 CHEMBL4756940 EC50 145.0 nM
Cc1cc(-c2ccc3[nH]nc(C(=O)Nc4ccc(OC5CCN(C)CC5)cc4)c3c2)sn1 CHEMBL4789136 EC50 147.0 nM
O=C(Nc1cncc(-c2ccc3[nH]nc(-c4cc5ccncc5[nH]4)c3n2)c1)C1CCCC1 CHEMBL4741036 EC50 147.0 nM
Fc1cccc(-c2cncc3[nH]c(-c4n[nH]cc4C#Cc4cncc(OC5CCNCC5)c4)nc23)c1 CHEMBL4763219 EC50 148.0 nM
O=C(Nc1cncc(-c2ccc3[nH]nc(-c4nc5c(-c6ccccc6F)ccnc5[nH]4)c3n2)c1)C(F)(F)F CHEMBL4776672 EC50 149.0 nM
CN(C)CCOc1cncc(-c2ccc3[nH]nc(-c4nc5c(-c6cccs6)cccc5[nH]4)c3n2)c1 CHEMBL4755388 EC50 150.0 nM
O=C(Nc1cncc(-c2cnc3[nH]nc(-c4cc5c(-c6cccnc6)cccc5[nH]4)c3c2)c1)C1CCC1 CHEMBL4755952 EC50 151.0 nM
CS(=O)(=O)NCc1cc(F)cc(-c2nccc3[nH]c(-c4n[nH]c5ccc(-c6cncc(NC(=O)Cc7ccccc7)c6)nc45)cc23)c1 CHEMBL4760946 EC50 151.0 nM
c1cncc(-c2cncc3[nH]c(-c4n[nH]c5ncc(-c6cncnc6)cc45)cc23)c1 CHEMBL4742941 EC50 156.0 nM
O=C(Nc1cncc(-c2ccc3[nH]nc(-c4cc5c(-c6ccccc6F)nccc5[nH]4)c3c2)c1)C1CCCC1 CHEMBL4757198 EC50 158.0 nM
CC(C)Nc1cncc(-c2cnc3[nH]nc(-c4nc5c(-c6cccc(F)c6)cncc5[nH]4)c3c2)c1 CHEMBL4781555 EC50 160.0 nM
O=C(Cc1ccccc1)Nc1cncc(-c2ccc3[nH]nc(-c4nc5c(-c6cccc(F)c6)cncc5[nH]4)c3c2)c1 CHEMBL4763425 EC50 164.0 nM
CC(C)Nc1cncc(-c2ccc3[nH]nc(-c4cc5c(-c6cccnc6)ccnc5[nH]4)c3c2)c1 CHEMBL4777044 EC50 164.0 nM
CO[C@H]1CC[C@H](C(=O)Nc2cc3cc(-c4cnn(C)c4CN4CCCCC4)ccc3cn2)CC1 CHEMBL4763084 EC50 164.0 nM
FC1(F)CCN(Cc2cncc(-c3ccc4[nH]nc(-c5cc6c(N7CCCCC7)ccnc6[nH]5)c4n3)c2)C1 CHEMBL4780802 EC50 166.0 nM
c1csc(-c2cncc3[nH]c(-c4n[nH]c5ncc(-c6cncc(CNCC7CCCC7)c6)cc45)nc23)c1 CHEMBL4749762 EC50 167.0 nM
COC(=O)C1(NC2=N/C(=C\c3ccc4ncsc4c3)C(=O)N2)C2CC3CC(C2)CC1C3 CHEMBL5417890 IC50 167.0 nM
O=C1NC(NC2CCC(F)(F)C2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5427398 IC50 173.0 nM
O=C1NC(NC2CCCC(F)(F)C2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5411888 IC50 175.0 nM
O=C1NC(N[C@@H]2CCCC[C@H]2O)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5417693 IC50 175.0 nM
c1cncc(-c2ccc3[nH]nc(-c4nc5c(-c6cccnc6)cncc5[nH]4)c3n2)c1 CHEMBL4784533 EC50 177.0 nM
Cc1nnc(C(=O)Nc2cc3cc(-c4cncn4C)ccc3cn2)s1 CHEMBL4787749 EC50 177.0 nM
O=C1NC(N[C@H](CO)c2ccccc2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5429783 IC50 178.0 nM
O=C1NC(N[C@@H](CO)c2ccccc2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5404544 IC50 179.0 nM
COc1cccc2c1[nH]c1c3ccncc3cc(C#N)c21 CHEMBL3885431 IC50 180.0 nM
O=C(Nc1cncc(-c2ccc3[nH]nc(-c4nc5c(-c6ccccc6F)cccc5[nH]4)c3n2)c1)C(F)(F)F CHEMBL4748619 EC50 180.0 nM
CN(C)Cc1cncc(-c2cc3c(-c4cc5c(-c6ccncc6)ccnc5[nH]4)n[nH]c3cn2)c1 CHEMBL4797314 EC50 180.0 nM
O=C(Cc1ccccc1)Nc1cncc(-c2ccc3[nH]nc(-c4cc5cnccc5[nH]4)c3c2)c1 CHEMBL4740858 EC50 180.0 nM
NC1CN(c2cncc(-c3ccc4[nH]nc(-c5nc6ccncc6[nH]5)c4c3)n2)C1 CHEMBL4747703 EC50 182.0 nM
O=C(Nc1cncc(-c2ccc3[nH]nc(-c4nc5c(-c6ccc(Cl)s6)ccnc5[nH]4)c3n2)c1)C1CCC1 CHEMBL4754669 EC50 183.0 nM
CS(=O)(=O)NCc1cc(F)cc(-c2nccc3[nH]c(-c4n[nH]c5ccc(-c6cncnc6)cc45)nc23)c1 CHEMBL4744601 EC50 186.0 nM
CN1CCN(c2ccnc3[nH]c(-c4n[nH]c5ccc(-c6cncc(NC(=O)CC(C)(C)C)c6)nc45)cc23)CC1 CHEMBL4798097 EC50 186.0 nM
Cc1cn(-c2nccc3[nH]c(-c4n[nH]c5ccc(-c6cncc(NC(=O)C(C)(C)C)c6)nc45)nc23)cn1 CHEMBL4779228 EC50 188.0 nM
CN(C)Cc1cncc(-c2cc3c(-c4cc5c(-c6ccncc6)cncc5[nH]4)n[nH]c3cn2)c1 CHEMBL4759225 EC50 188.0 nM
CS(=O)(=O)NCc1cc(F)cc(-c2cncc3[nH]c(-c4n[nH]c5cnc(-c6cncc(NC(=O)C7CCC7)c6)cc45)cc23)c1 CHEMBL4745159 EC50 188.0 nM
COc1ccc2c(c1)[nH]c1c3ccncc3cc(C#N)c21 CHEMBL3883660 IC50 190.0 nM
O=C1NC(NC23CC4CC(CC(F)(C4)C2)C3)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5438158 IC50 194.0 nM
O=C1NC(NC[C@@H](O)c2ccccc2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5428132 IC50 194.0 nM
O=C1NC(N[C@@H]2CCCCC[C@@H]2O)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5414514 IC50 195.0 nM
CC(C)Nc1cncc(-c2cnc3[nH]nc(-c4cc5c(-c6ccccc6F)nccc5[nH]4)c3c2)c1 CHEMBL4791233 EC50 196.0 nM
CN(C)Cc1cncc(-c2ccc3[nH]nc(-c4nc5c(-c6cccc(F)c6)nccc5[nH]4)c3n2)c1 CHEMBL4786124 EC50 197.0 nM
CC(C)CC(=O)Nc1cncc(-c2cc3c(-c4cc5c(-c6cc(F)cc(CNS(C)(=O)=O)c6)cncc5[nH]4)n[nH]c3cn2)c1 CHEMBL4761655 EC50 198.0 nM
O=C(Nc1cc2cc(-c3cnn4c3CCNC4)ccc2cn1)c1ccc(OC(F)F)cc1 CHEMBL4794929 EC50 200.0 nM
CCCCC(=O)Nc1cncc(-c2cnc3[nH]nc(-c4cc5c(-c6ccncc6)cncc5[nH]4)c3c2)c1 CHEMBL4792964 EC50 201.0 nM
O=C1NC(Nc2cccnc2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5427325 IC50 201.0 nM
Cn1ccc(NC2=N/C(=C\c3ccc4ncsc4c3)C(=O)N2)n1 CHEMBL5407529 IC50 201.0 nM
COC[C@@H](CC(C)C)NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5426285 IC50 201.0 nM
O=C(Nc1cncc(-c2cc3c(-c4cc5c(-c6ccc(F)cc6)nccc5[nH]4)n[nH]c3cn2)c1)C1CC1 CHEMBL4753208 EC50 202.0 nM
Cc1ccc(-c2cncc3[nH]c(-c4n[nH]c5cnc(-c6cncc(N)c6)cc45)nc23)s1 CHEMBL4756438 EC50 203.0 nM
FC1(F)CCN(Cc2cncc(-c3cc4c(-c5cc6cccnc6[nH]5)n[nH]c4cn3)c2)C1 CHEMBL4784018 EC50 203.0 nM
CC(C)CC(=O)Nc1cncc(-c2ccc3[nH]nc(-c4cc5c(N6CCN(C)CC6)ccnc5[nH]4)c3n2)c1 CHEMBL4795751 EC50 204.0 nM
CC(C)Nc1cncc(-c2ccc3[nH]nc(-c4nc5c(-c6ccoc6)nccc5[nH]4)c3c2)c1 CHEMBL4751276 EC50 205.0 nM
Nc1cncc(-c2cc3c(-c4cc5c(-c6ccccc6F)cncc5[nH]4)n[nH]c3cn2)c1 CHEMBL4748029 EC50 205.0 nM
O=C1NC(N[C@@H]2CCC[C@@H](O)C2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5415622 IC50 205.0 nM
O=C(Nc1cncc(-c2ccc3[nH]nc(-c4nc5ccncc5[nH]4)c3c2)c1)C1CC1 CHEMBL4790964 EC50 206.0 nM
Oc1ccc(-c2n[nH]c3ncc(-c4ccc(O)c(O)c4)cc23)cc1 CHEMBL4873449 IC50 206.8 nM
c1cncc(-c2ccc3[nH]nc(-c4nc5c(-c6cccnc6)cncc5[nH]4)c3c2)c1 CHEMBL4749962 EC50 207.0 nM
Nc1cncc(-c2ccc3[nH]nc(-c4nc5c(-c6ccccc6F)cccc5[nH]4)c3n2)c1 CHEMBL4793856 EC50 209.0 nM
CC(C)Nc1cncc(-c2ccc3[nH]nc(-c4nc5c(-c6ccccc6F)cncc5[nH]4)c3c2)c1 CHEMBL4790668 EC50 209.0 nM
c1cncc(-c2cc3c(-c4nc5ccccc5[nH]4)n[nH]c3cn2)c1 CHEMBL4764391 EC50 209.0 nM
COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 CHEMBL509032 Kd 210.0 nM
CC(C)C[C@H](COC1CC1)NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5396386 IC50 211.0 nM
O=C1NC(Nc2ccccn2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5417527 IC50 211.0 nM
O=C1NC(NC2CC3(CCC3)C2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5427895 IC50 212.0 nM
CC(C)Nc1cncc(-c2ccc3[nH]nc(-c4nc5c(-c6cccnc6)cncc5[nH]4)c3n2)c1 CHEMBL4797078 EC50 213.0 nM
CCC(=O)Nc1cncc(-c2ccc3[nH]nc(-c4nc5c(N6CCCCC6)cncc5[nH]4)c3n2)c1 CHEMBL4795539 EC50 213.0 nM
CCNCc1cncc(-c2cc3c(-c4cc5c(-c6cccnc6)cncc5[nH]4)n[nH]c3cn2)c1 CHEMBL4750750 EC50 214.0 nM
O=C1NC(NC23CC4CC(CC(O)(C4)C2)C3)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5405059 IC50 215.0 nM
CCC(=O)Nc1cncc(-c2ccc3[nH]nc(-c4cc5c(-c6cc(F)cc(CNS(C)(=O)=O)c6)cncc5[nH]4)c3c2)c1 CHEMBL4753972 EC50 216.0 nM
c1ncc(-c2ccc3[nH]nc(-c4cc5c(-c6ccoc6)nccc5[nH]4)c3c2)cn1 CHEMBL4797627 EC50 217.0 nM
CC(C)CC(=O)Nc1cncc(-c2ccc3[nH]nc(-c4nc5c(-c6cccc(F)c6)ccnc5[nH]4)c3c2)c1 CHEMBL4788446 EC50 218.0 nM
CN(C)Cc1cncc(-c2cc3c(-c4cc5c(-c6cccc(F)c6)nccc5[nH]4)n[nH]c3cn2)c1 CHEMBL4741293 EC50 218.0 nM
COC[C@@H](CC(C)C)NC1=N/C(=C\c2ccc3ncsc3n2)C(=O)N1 CHEMBL5429359 IC50 219.2 nM
Fc1ccccc1-c1nccc2[nH]c(-c3n[nH]c4cnc(-c5cncc(CN6CCCC6)c5)cc34)cc12 CHEMBL4756072 EC50 222.0 nM
O=C1NC(N[C@@H]2CCC[C@H]2O)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5429789 IC50 224.0 nM
Cc1ncc(-c2cnc3[nH]nc(-c4cc5c(-c6ccncc6)cncc5[nH]4)c3c2)n1C CHEMBL4759093 EC50 227.0 nM
CC(C)Nc1cncc(-c2ccc3[nH]nc(-c4nc5c(-c6ccoc6)nccc5[nH]4)c3n2)c1 CHEMBL4800320 EC50 230.0 nM
O=C(Nc1cncc(-c2cnc3[nH]nc(-c4cc5c(N6CCCCC6)nccc5[nH]4)c3c2)c1)C1CC1 CHEMBL4800596 EC50 231.0 nM
CC(C)C(=O)Nc1cncc(-c2cnc3[nH]nc(-c4cc5c(-c6cc(F)cc(CNS(C)(=O)=O)c6)cncc5[nH]4)c3c2)c1 CHEMBL4799161 EC50 236.0 nM
c1cnc2[nH]c(-c3n[nH]c4ccc(-c5cncc(OCCN6CCCC6)c5)cc34)cc2c1 CHEMBL4741593 EC50 246.0 nM
Fc1cccc(-c2nccc3[nH]c(-c4n[nH]c5ccc(-c6cncc(CN7CCCCC7)c6)nc45)cc23)c1 CHEMBL4797290 EC50 252.0 nM
CN1CCN(c2ccnc3[nH]c(-c4n[nH]c5ccc(-c6cncc(NC(=O)c7ccccc7)c6)nc45)cc23)CC1 CHEMBL4763400 EC50 258.0 nM
Cn1ncc(-c2ccc3cnc(NC(=O)c4ccc(OC(F)F)cc4)cc3c2)c1CO CHEMBL4797187 EC50 261.0 nM
COC(CNC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1)Cc1ccccc1 CHEMBL5421200 IC50 262.0 nM
Cc1cn(-c2cncc3[nH]c(-c4n[nH]c5ccc(-c6cncc(NC(=O)C(C)(C)C)c6)nc45)nc23)cn1 CHEMBL4757581 EC50 263.0 nM
COC(CNC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1)C1CCCCC1 CHEMBL5423402 IC50 263.0 nM
O=C1NC(NC2CCCCCC2)=N/C1=C\c1ccc2[nH]ncc2c1 CHEMBL5413427 IC50 266.0 nM
CCNCc1cncc(-c2ccc3[nH]nc(-c4cc5ccccc5[nH]4)c3c2)c1 CHEMBL4786094 EC50 269.0 nM
CCCCC(=O)Nc1cncc(-c2ccc3[nH]nc(-c4cc5c(N6CCCCC6)nccc5[nH]4)c3n2)c1 CHEMBL4790903 EC50 269.0 nM
COC(CNC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1)c1ccccc1 CHEMBL5424074 IC50 270.0 nM
FC1(F)CCN(Cc2cncc(-c3ccc4[nH]nc(-c5cc6c(N7CCCCC7)cccc6[nH]5)c4c3)c2)C1 CHEMBL4781079 EC50 279.0 nM
CC(C)Nc1cncc(-c2ccc3[nH]nc(-c4nc5c(-c6cccnc6)ccnc5[nH]4)c3n2)c1 CHEMBL4755713 EC50 280.0 nM
CN1CCN(c2ccc(C(=O)N3CCN(c4cc(C(=O)Nc5cc6cc(-c7cnn(C)c7)ccc6cn5)ccn4)CC3)cn2)CC1 CHEMBL4764269 EC50 280.0 nM
CC[C@@H](CO)Nc1ccc2ncc(-c3cccc(NC(C)=O)c3)n2n1 CHEMBL4061526 IC50 280.0 nM
O=C1NC(NCc2ccccc2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5405969 IC50 280.0 nM
COC(=O)[C@H](C)NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5423907 IC50 284.0 nM
COC12CC3CC(CC(NC4=N/C(=C\c5ccc6ncsc6c5)C(=O)N4)(C3)C1)C2 CHEMBL5417147 IC50 284.0 nM
CCC(=O)Nc1cncc(-c2cc3c(-c4cc5c(N6CCN(C)CC6)nccc5[nH]4)n[nH]c3cn2)c1 CHEMBL4795743 EC50 285.0 nM
O=C1NC(NC2CCCCCC2)=N/C1=C\c1ccc2ncoc2c1 CHEMBL5430824 IC50 285.0 nM
CN1CCN(c2nccc3[nH]c(-c4n[nH]c5ccc(-c6cncc(NC(=O)c7ccccc7)c6)cc45)cc23)CC1 CHEMBL4779082 EC50 291.0 nM
CC(C)Nc1cncc(-c2cnc3[nH]nc(-c4cc5c(-c6cccnc6)ccnc5[nH]4)c3c2)c1 CHEMBL4745435 EC50 292.0 nM
CN(C)Cc1cncc(-c2ccc3[nH]nc(-c4cc5c(N6CCCCC6)nccc5[nH]4)c3c2)c1 CHEMBL4740574 EC50 293.0 nM
O=C1NC(NC(CF)c2ccccc2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5404644 IC50 293.0 nM
Fc1cccc(-c2cncc3[nH]c(-c4n[nH]c5ncc(-c6cncc(CN7CCCCC7)c6)cc45)cc23)c1 CHEMBL4790211 EC50 295.0 nM
O=C1NC(N[C@@H](CO)Cc2ccccc2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5435490 IC50 295.0 nM
c1cncc(-c2ccc3[nH]nc(-c4nc5c(-c6cccnc6)cccc5[nH]4)c3n2)c1 CHEMBL4744838 EC50 296.0 nM
O=C1NC(NCC(O)C2CCCCC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5436133 IC50 299.0 nM
COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl CHEMBL288441 Kd 300.0 nM
CNC(=O)c1ccc(Nc2nc(OC3CCCC3)c3c(-c4ccc5nc(C)oc5c4)c[nH]c3n2)c(OC)c1 CHEMBL4062218 IC50 300.0 nM
O=C1NCc2c(Cl)cc3c(-c4ccccc4)c[nH]c3c21 CHEMBL5290575 IC50 300.0 nM
CN1CCN(c2nccc3[nH]c(-c4n[nH]c5cnc(-c6cncc(NC(=O)c7ccccc7)c6)cc45)cc23)CC1 CHEMBL4777935 EC50 302.0 nM
CN1CCN(c2nccc3[nH]c(-c4n[nH]c5cnc(-c6cncc(NC(=O)C7CCCCC7)c6)cc45)cc23)CC1 CHEMBL4749506 EC50 303.0 nM
CN1CCN(c2cncc3[nH]c(-c4n[nH]c5ccc(-c6cncc(NC(=O)CC7CCNCC7)c6)cc45)cc23)CC1 CHEMBL4776216 EC50 303.0 nM
CCNCc1cncc(-c2cnc3[nH]nc(-c4cc5c(-c6cc(F)cc(CNS(C)(=O)=O)c6)nccc5[nH]4)c3c2)c1 CHEMBL4754837 EC50 305.0 nM
c1cc(-c2cncc3[nH]c(-c4n[nH]c5ccc(-c6cncc(CN7CCCCC7)c6)nc45)cc23)ccn1 CHEMBL4788538 EC50 306.0 nM
CC(C)C(=O)Nc1cncc(-c2cc3c(-c4cc5c(-c6cccc(F)c6)cncc5[nH]4)n[nH]c3cn2)c1 CHEMBL4743234 EC50 307.0 nM
c1cncc(-c2ccc3[nH]nc(-c4nc5c(-c6cccnc6)ccnc5[nH]4)c3n2)c1 CHEMBL4777787 EC50 308.0 nM
Cc1n[nH]c2ccc(-c3cncc(N[C@H]4CC[C@H](O)CC4)n3)cc12 CHEMBL4791039 EC50 309.0 nM
O=C1NC(N[C@@H]2CCCC[C@@H](O)C2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5437778 IC50 309.0 nM
Nc1nc(Nc2ccc(S(N)(=O)=O)cc2)nn1C(=O)c1c(F)cccc1F CHEMBL191003 Kd 310.0 nM
Cn1cc(C2=C(c3cccc(NCC(O)CO)c3)C(=O)NC2=O)c2cc(F)ccc21 CHEMBL1082152 Kd 310.0 nM
Cc1n[nH]c2ccc(-c3cncc(O[C@H]4CCNCC4(F)F)n3)cc12 CHEMBL4764315 EC50 313.0 nM
Cn1ncc(-c2ccc3cnc(NC(=O)C4CCN(C(=O)c5ccccc5)CC4)cc3c2)c1CN1CCCCC1 CHEMBL4751301 EC50 318.0 nM
COc1ccc2c(c1)[nH]c1c3c(OC)cncc3cc(C#N)c21 CHEMBL3884821 IC50 320.0 nM
CC(C)Nc1cncc(-c2ccc3[nH]nc(-c4nc5c(-c6cccnc6)nccc5[nH]4)c3n2)c1 CHEMBL4763435 EC50 322.0 nM
CN1CCN(c2nccc3[nH]c(-c4n[nH]cc4/C=C/c4cncc(F)c4)nc23)CC1 CHEMBL4743901 EC50 326.0 nM
CS(=O)(=O)NCc1cc(F)cc(-c2nccc3[nH]c(-c4n[nH]c5ncc(-c6cncc(OCc7ccccc7)c6)cc45)cc23)c1 CHEMBL4747076 EC50 329.0 nM
CC(C)Nc1cncc(-c2ccc3[nH]nc(-c4cc5c(-c6cccnc6)cncc5[nH]4)c3c2)c1 CHEMBL4794971 EC50 330.0 nM
c1cc(-c2ccoc2)c2cc(-c3n[nH]c4ccc(-c5cncc(CNCC6CCCC6)c5)nc34)[nH]c2c1 CHEMBL4749966 EC50 336.0 nM
CN1CCN(c2ccnc3[nH]c(-c4n[nH]c5cnc(-c6cncc(CNCC7CCCC7)c6)cc45)cc23)CC1 CHEMBL4751483 EC50 340.0 nM
O=C1NC(NC2CC23CCCCC3)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5434921 IC50 341.0 nM
O=C(Nc1cncc(-c2cc3c(-c4cc5c(N6CCCCC6)nccc5[nH]4)n[nH]c3cn2)c1)C1CCC1 CHEMBL4796975 EC50 342.0 nM
O=C(Nc1cnccc1NC(=O)C1CC1)c1n[nH]c2ccc(-c3cccnc3)cc12 CHEMBL4778412 EC50 343.0 nM
CN1CCN(c2nccc3[nH]c(-c4n[nH]c5ccc(-c6cncc(N)c6)nc45)nc23)CC1 CHEMBL4749876 EC50 344.0 nM
CCCCC(=O)Nc1cncc(-c2ccc3[nH]nc(-c4cc5cccnc5[nH]4)c3c2)c1 CHEMBL4758986 EC50 344.0 nM
Cc1nc2ccc3sc(NC(=O)c4ccc5scnc5c4)nc3c2s1 CHEMBL5287646 IC50 346.0 nM
c1cncc(-c2cnc3[nH]nc(-c4cc5cccnc5[nH]4)c3c2)c1 CHEMBL4761786 EC50 351.0 nM
Cc1cncc(NC(=O)c2n[nH]c3ccc(-c4cncc(CN5CCCCC5)c4)cc23)c1 CHEMBL4776499 EC50 352.0 nM
CC1(C)CCC(NC2=N/C(=C\c3ccc4ncsc4c3)C(=O)N2)CO1 CHEMBL5436147 IC50 357.0 nM
CC(C)(C)C(=O)Nc1cncc(-c2cc3c(-c4nc5c(-c6ccc(F)s6)nccc5[nH]4)n[nH]c3cn2)c1 CHEMBL4798005 EC50 358.0 nM
Cc1n[nH]c2ccc(-c3cncc(OC[C@H](N)Cc4ccccc4)n3)cc12 CHEMBL4780416 EC50 361.0 nM
CCCCC(=O)Nc1cncc(-c2ccc3[nH]nc(-c4nc5c(-c6ccoc6)cncc5[nH]4)c3n2)c1 CHEMBL4786418 EC50 361.0 nM
c1ccc2[nH]c(-c3n[nH]c4ncc(-c5cncc(CN6CCCC6)c5)cc34)cc2c1 CHEMBL4793740 EC50 362.0 nM
COc1cc(Nc2nccc(-c3cnn4nc(OC)ccc34)n2)cc(C(F)(F)F)c1 CHEMBL187139 IC50 363.0 nM
O=C(Nc1cncc(-c2ccc3[nH]nc(-c4cc5cccnc5[nH]4)c3c2)c1)C1CCCC1 CHEMBL4776789 EC50 365.0 nM
NC[C@H](NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1)c1ccccc1 CHEMBL5406081 IC50 367.0 nM
FC1(F)CCN(Cc2cncc(-c3ccc4[nH]nc(-c5cc6cccnc6[nH]5)c4n3)c2)C1 CHEMBL4792259 EC50 370.0 nM
Cc1csc(CNC2=N/C(=C\c3ccc4ncsc4c3)C(=O)N2)n1 CHEMBL5434349 IC50 376.0 nM
O=C(Nc1ccc(CN2CCCC2)cc1)c1n[nH]c2ccc(-c3cnccn3)cc12 CHEMBL4743500 EC50 378.0 nM
Cn1ncc2cc(/C=C3\N=C(NC4CCCCCC4)NC3=O)ccc21 CHEMBL5409493 IC50 381.0 nM
CO[C@@H]1CCCC[C@H]1NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5394394 IC50 382.0 nM
CC(C)C(=O)Nc1cncc(-c2cc3c(-c4cc5c(-c6ccncc6)nccc5[nH]4)n[nH]c3cn2)c1 CHEMBL4787630 EC50 389.0 nM
O=C(Nc1ccc(OC(F)F)cc1)c1n[nH]c2ccc(-c3cnc4n3CCNC4)cc12 CHEMBL4747908 EC50 391.0 nM
CO[C@H]1CCCCC[C@H]1NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5411157 IC50 391.0 nM
CC(C)CC(=O)Nc1cncc(-c2cc3c(-c4cc5c(-c6cccs6)nccc5[nH]4)n[nH]c3cn2)c1 CHEMBL4753467 EC50 392.0 nM
O=C1NC(N[C@H]2CC[C@H](O)CC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5422936 IC50 392.0 nM
CO[C@@H]1CCCC[C@@H](NC2=N/C(=C\c3ccc4ncsc4c3)C(=O)N2)C1 CHEMBL5440511 IC50 399.0 nM
CC(C)C[C@H](CF)NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5426735 IC50 403.0 nM
O=C1NC(N[C@H]2CCOC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5424363 IC50 405.0 nM
FC1(F)CCN(Cc2cncc(-c3ccc4[nH]nc(-c5cc6c(-c7cccnc7)cncc6[nH]5)c4n3)c2)C1 CHEMBL4763204 EC50 408.0 nM
CCOC[C@@H](CC(C)C)NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5409730 IC50 413.0 nM
CC(C)(C)CC(=O)Nc1cncc(-c2cc3c(-c4cc5c(-c6ccccc6F)nccc5[nH]4)n[nH]c3cn2)c1 CHEMBL4788394 EC50 414.0 nM
Cn1cc(-c2cc3c(-c4nc5c(-c6cccc(F)c6)cncc5[nH]4)n[nH]c3cn2)cn1 CHEMBL4760846 EC50 416.0 nM
Fc1ccc(-c2nccc3[nH]c(-c4n[nH]c5cnc(-c6cncc(CN7CCC(F)(F)C7)c6)cc45)cc23)cc1 CHEMBL4788785 EC50 417.0 nM
O=C(CC1CCNCC1)Nc1cncc(-c2ccc3[nH]nc(-c4cc5c(-c6ccoc6)ccnc5[nH]4)c3n2)c1 CHEMBL4786287 EC50 418.0 nM
Cc1n[nH]c2ccc(-c3cncc(N[C@H]4CCNC[C@@H]4F)n3)cc12 CHEMBL4741792 EC50 424.0 nM
CN1CCN(c2nccc3[nH]c(-c4n[nH]c5ccc(-c6cncc(NC(=O)CC7CCNCC7)c6)cc45)cc23)CC1 CHEMBL4749220 EC50 428.0 nM
O=C1NC(NC2CCCCOC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5424272 IC50 428.0 nM
CC(C)(C)CNc1ncnc2ccc(-c3ccc4c(c3)OCO4)cc12 CHEMBL1551169 IC50 435.0 nM
CCNCc1cncc(-c2ccc3[nH]nc(-c4cc5c(-c6cccnc6)ccnc5[nH]4)c3c2)c1 CHEMBL4785809 EC50 443.0 nM
COC[C@@H](NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1)c1ccccc1 CHEMBL5401217 IC50 450.0 nM
CCCC(=O)Nc1cncc(-c2ccc3[nH]nc(-c4cc5c(-c6ccncc6)cncc5[nH]4)c3c2)c1 CHEMBL4761515 EC50 460.0 nM
CC(C)C[C@H](CO)NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5412105 IC50 461.3 nM
COC[C@@H](CC(C)C)NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1C CHEMBL5085086 IC50 465.7 nM
O=C1NC(NC2CCC(F)(F)CC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5432739 IC50 467.0 nM
c1cncc(-c2cc3c(-c4cc5c(-c6cccnc6)cncc5[nH]4)n[nH]c3cn2)c1 CHEMBL4758642 EC50 468.0 nM
c1csc(CNc2ncnc3ccc(-c4ccc5c(c4)OCO5)cc23)c1 CHEMBL567331 Kd 470.0 nM
c1cc2[nH]c(-c3n[nH]c4ccc(-c5cncc(CN6CCCCC6)c5)cc34)cc2c(N2CCCCC2)n1 CHEMBL4757427 EC50 470.0 nM
CS(=O)(=O)NCc1cc(F)cc(-c2nccc3[nH]c(-c4n[nH]c5cnc(-c6cncc(CNCC7CCCC7)c6)cc45)cc23)c1 CHEMBL4793214 EC50 471.0 nM
O=C1NC(NCC(O)Cc2ccccc2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5398512 IC50 472.0 nM
CC(C)C[C@@H](CO)NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5408047 IC50 473.9 nM
O=C1NC(NCc2ccccn2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5406568 IC50 478.0 nM
O=C(Nc1c[nH]nc1-c1nc2c(-c3cccc(F)c3)cccc2[nH]1)c1cccnc1 CHEMBL4788972 EC50 485.0 nM
O=C1NC(NC2COCCOC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5421636 IC50 488.0 nM
O=C1NC(NC2COC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5412372 IC50 491.0 nM
Fc1cccc(-c2cccc3[nH]c(-c4n[nH]cc4/C=C/c4cncc(CN5CCCC5)c4)nc23)c1 CHEMBL4788267 EC50 492.0 nM
COc1cncc(-c2cc3c(-c4nc5c(-c6cccc(F)c6)cncc5[nH]4)n[nH]c3cn2)c1 CHEMBL4764129 EC50 493.0 nM
O=C1NC(N[C@@H]2CCCC[C@@H]2O)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5427523 IC50 497.0 nM
NC(=O)c1n[nH]c2ccc(-c3cncc(CN4CCCCC4)c3)cc12 CHEMBL4792282 EC50 498.0 nM
CN1CCN(c2cncc3[nH]c(-c4n[nH]c5ccc(-c6cncc(N)c6)nc45)nc23)CC1 CHEMBL4757486 EC50 500.0 nM
Cc1ccc(CNC2=N/C(=C\c3ccc4ncsc4c3)C(=O)N2)c(C)c1 CHEMBL5423063 IC50 518.0 nM
CC(C)CC(=O)Nc1cncc(-c2cc3c(-c4nc5c(-c6ccoc6)cccc5[nH]4)n[nH]c3cn2)c1 CHEMBL4787474 EC50 521.0 nM
CN1CCN(c2nccc3[nH]c(-c4n[nH]c5ccc(-c6cncc(CN7CCCCC7)c6)nc45)cc23)CC1 CHEMBL4754230 EC50 524.0 nM
CCOC(=O)c1c(/C(C#N)=C\N)c2ccc(Cl)c(Cl)c2n1C CHEMBL1236620 IC50 530.0 nM
CCOC(=O)c1c(/C(C#N)=C/N)c2ccc(Cl)c(Cl)c2n1C CHEMBL4090007 IC50 530.0 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL388978 IC50 530.0 nM
CC1(NC2=N/C(=C\c3ccc4ncsc4c3)C(=O)N2)CCNC1=O CHEMBL5423406 IC50 532.0 nM
O=C(Nc1cncc(-c2cc3c(-c4cc5c(-c6cccnc6)cccc5[nH]4)n[nH]c3cn2)c1)C1CC1 CHEMBL4782218 EC50 537.0 nM
O=C1NC(N[C@@H]2CCC[C@@H]2O)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5423395 IC50 537.0 nM
CCC(=O)Nc1cncc(-c2cnc3[nH]nc(-c4cc5c(-c6cccnc6)cccc5[nH]4)c3c2)c1 CHEMBL4747342 EC50 538.0 nM
CN(C)c1cncc(-c2cc3c(-c4cc5cnccc5[nH]4)n[nH]c3cn2)c1 CHEMBL4744291 EC50 538.0 nM
CC(C)(C)CC(=O)Nc1cncc(-c2ccc3[nH]nc(-c4nc5ccncc5[nH]4)c3n2)c1 CHEMBL4748882 EC50 558.0 nM
CCNCc1cncc(-c2ccc3[nH]nc(-c4cc5cccnc5[nH]4)c3n2)c1 CHEMBL4797436 EC50 562.0 nM
O=C(Nc1ccc(N2CCNCC2)nc1)c1n[nH]cc1/C=C/c1cccnc1 CHEMBL4777426 EC50 563.0 nM
CN(C)Cc1cncc(-c2ccc3[nH]nc(-c4cc5cccnc5[nH]4)c3n2)c1 CHEMBL4789529 EC50 566.0 nM
CC(C)C(=O)Nc1cncc(-c2ccc3[nH]nc(-c4cc5c(N6CCN(C)CC6)nccc5[nH]4)c3c2)c1 CHEMBL4740045 EC50 569.0 nM
O=C1NC(Nc2cncnc2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5407276 IC50 571.0 nM
CO[C@@H]1CCC[C@@H](NC2=N/C(=C\c3ccc4ncsc4c3)C(=O)N2)C1 CHEMBL5440139 IC50 575.0 nM
Cc1cc2[nH]nc(C(=O)Nc3ccc(CN4CCCC4)cc3)c2cc1-c1cccnc1 CHEMBL4797560 EC50 581.0 nM
O=C(Nc1cccnc1)c1n[nH]c2cnc(-c3cncc(CN4CCCCC4)c3)cc12 CHEMBL4793803 EC50 601.0 nM
O=C1NC(N[C@@H]2CCCOC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5397281 IC50 604.0 nM
CC(=O)NC12CC3CC(C1)CC(NC1=N/C(=C\c4ccc5ncsc5c4)C(=O)N1)(C3)C2 CHEMBL5422654 IC50 610.0 nM
CC(C)Oc1ccc(NC(=O)c2n[nH]c3ccc(-c4cncc(CN5CCCCC5)c4)cc23)cn1 CHEMBL4762155 EC50 616.0 nM
O=C1NC(N[C@H]2C3CC4CC2C[C@](O)(C4)C3)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5428651 IC50 626.0 nM
Fc1ccc(-c2nnc(-c3n[nH]cc3/C=C/c3cccnc3)o2)cc1 CHEMBL4756490 EC50 627.0 nM
O=C1NC(NC2CCCCCCC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5430192 IC50 627.0 nM
CO[C@H]1CCCC[C@@H]1NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5413743 IC50 628.0 nM
CC[C@@H]1C(=O)N(C)c2cnc(Nc3ccc(C(=O)NC4CCN(C)CC4)cc3OC)nc2N1C1CCCC1 CHEMBL513909 Kd 630.0 nM
COC1=CC2C(=O)NC3=Cc4ccc(OC)cc4C(=C1OC)C32 CHEMBL5279705 IC50 639.9 nM
O=C1NC(N[C@@H]2CCCC[C@H](O)C2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5401675 IC50 646.0 nM
O=C1NC(N[C@@H]2COCC[C@H]2O)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5431345 IC50 655.0 nM
O=C1NC(NC23CC4CC(CC(NC(=O)C5CC5)(C4)C2)C3)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5418722 IC50 658.0 nM
CN1CCN(c2ccnc3[nH]c(-c4n[nH]c5ncc(-c6cn[nH]c6)cc45)cc23)CC1 CHEMBL4747803 EC50 678.0 nM
Cc1ncc(-c2ccc3cnc(NC(=O)C4(F)CC4)cc3c2)n1C CHEMBL4752888 EC50 678.0 nM
Cn1cc(-c2ccc3cnc(NC(=O)C4CCN(S(C)(=O)=O)CC4)cc3c2)cn1 CHEMBL5285332 IC50 681.1 nM
O=C1NC(N[C@@H]2CCC[C@@H](O)CC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5420497 IC50 686.0 nM
O=C1NC(N[C@@H](CO)CC2CC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5397157 IC50 686.0 nM
O=C1NC(NCCc2ccccn2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5401073 IC50 697.0 nM
O=C1NC(NCC2CCOCC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5425492 IC50 698.0 nM
O=C1NC(Nc2ccccc2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5418020 IC50 698.0 nM
COc1ccc(/C=C2\N=C(Nc3ccc(N4CCN(C)CC4)cc3)NC2=O)cc1O CHEMBL5416942 IC50 700.0 nM
CC(C)(C)NC(=O)OC12CC3CC(CC(NC4=N/C(=C\c5ccc6ncsc6c5)C(=O)N4)(C3)C1)C2 CHEMBL5421442 IC50 709.0 nM
COc1ccc2[nH]c3c4ccncc4cc(C#N)c3c2c1 CHEMBL3883639 IC50 710.0 nM
O=C1NC(Nc2cccc(OC(F)F)c2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5409693 IC50 710.0 nM
O=C1NC(N[C@H]2c3ccccc3C[C@@H]2O)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5429404 IC50 713.0 nM
O=C1NC(NCc2cccnc2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5395707 IC50 716.0 nM
O=C(N[C@H]1C[C@@H]1c1ccccc1)c1n[nH]c2ccc(-c3cncc(CN4CCCCC4)c3)cc12 CHEMBL4755660 EC50 717.0 nM
O=C1NC(N[C@@H](CO)CC2CCC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5402979 IC50 720.0 nM
Cc1ccc(CNC2=N/C(=C\c3ccc4ncsc4c3)C(=O)N2)o1 CHEMBL5439185 IC50 722.0 nM
CN1CCC(Oc2ccc(NC(=O)c3n[nH]cc3/C=C/c3cccnc3)cn2)CC1 CHEMBL4799387 EC50 733.0 nM
CC1(C)C2CCC1(C)[C@H](NC1=N/C(=C\c3ccc4ncsc4c3)C(=O)N1)C2 CHEMBL5412900 IC50 738.0 nM
CN1CCN(C(=O)C(C)(C)c2ccc(C(=O)Cc3cn4cc(-c5ccncc5)ccc4n3)cc2)CC1 CHEMBL5288391 IC50 739.6 nM
CN1CCN(c2nccc3[nH]c(-c4n[nH]c5ncc(-c6cncc(NC(=O)C7CCCC7)c6)cc45)cc23)CC1 CHEMBL4782101 EC50 741.0 nM
O=C1NC(N[C@@H]2CCOC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5425635 IC50 747.0 nM
CC(C)(C)C(=O)Nc1cncc(-c2ccc3[nH]nc(-c4nc5c(-c6ccc(F)s6)ccnc5[nH]4)c3c2)c1 CHEMBL4776636 EC50 754.0 nM
CCCCC(=O)Nc1cncc(-c2cc3c(-c4cc5c(-c6cc(F)cc(CNS(C)(=O)=O)c6)nccc5[nH]4)n[nH]c3cn2)c1 CHEMBL4759630 EC50 776.0 nM
O=C1NC(N[C@@H]2CCC[C@H](O)C2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5393925 IC50 784.0 nM
Fc1ccccc1-c1nccc2[nH]c(-c3n[nH]c4cnc(-c5cn[nH]c5)cc34)cc12 CHEMBL4762727 EC50 785.0 nM
O=C1NC(NC2CCCCC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5430357 IC50 787.0 nM
COC(=O)[C@@H](NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1)C(C)C CHEMBL5416274 IC50 791.0 nM
O=C1NC(NC2CCCCC2)=N/C1=C\c1ccc2[nH]ncc2c1 CHEMBL5422413 IC50 794.0 nM
C[C@@H]1[C@H]2C[C@@H](C[C@H]1NC1=N/C(=C\c3ccc4ncsc4c3)C(=O)N1)C2(C)C CHEMBL5416470 IC50 795.0 nM
CC(C)C(=O)Nc1cncc(-c2cnc3[nH]nc(-c4cc5c(N6CCN(C)CC6)nccc5[nH]4)c3c2)c1 CHEMBL4797092 EC50 800.0 nM
CN1CCN(c2ccc(NC3=N/C(=C\c4ccc5c(c4)OCO5)C(=O)N3)cc2)CC1 CHEMBL5179655 IC50 800.0 nM
Cn1cnc2ccc(/C=C3\N=C(NC4CCCCCC4)NC3=O)cc21 CHEMBL5423245 IC50 804.0 nM
CO[C@H]1CCCC[C@@H](NC2=N/C(=C\c3ccc4ncsc4c3)C(=O)N2)C1 CHEMBL5422857 IC50 804.0 nM
COCC(Cc1ccccc1)NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5406461 IC50 808.0 nM
O=C1NC(NC23CC4CC(CC(C4)C2)C3)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5091238 IC50 811.0 nM
Fc1ccc(-c2cncc3[nH]c(-c4n[nH]c5ncc(-c6cncnc6)cc45)cc23)cc1 CHEMBL4741528 EC50 817.0 nM
CN1CCN(c2ccnc3[nH]c(-c4n[nH]c5ccc(-c6cncc(N)c6)nc45)nc23)CC1 CHEMBL4763984 EC50 843.0 nM
CO[C@@H]1Cc2ccccc2[C@H]1NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5414635 IC50 848.0 nM
CO[C@H]1CCC[C@H](NC2=N/C(=C\c3ccc4ncsc4c3)C(=O)N2)CC1 CHEMBL5396280 IC50 850.0 nM
COC(=O)[C@@H](CC(C)C)NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5405680 IC50 852.0 nM
O=C1NC(N[C@H]2CCC[C@H](O)CC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5438325 IC50 869.0 nM
CO[C@H]1CC[C@H](NC2=N/C(=C\c3ccc4ncsc4c3)C(=O)N2)CC1 CHEMBL5429086 IC50 880.0 nM
CN1CCN(c2nccc3[nH]c(-c4n[nH]c5ccc(-c6cncc(CN7CCCC7)c6)cc45)cc23)CC1 CHEMBL4793656 EC50 885.0 nM
FC1(F)CCN(Cc2cncc(-c3cnc4[nH]nc(-c5cc6c(-c7ccncc7)cccc6[nH]5)c4c3)c2)C1 CHEMBL4753143 EC50 895.0 nM
CN1CCN(c2cccc3[nH]c(-c4n[nH]c5ccc(-c6cncc(CN7CCCCC7)c6)cc45)cc23)CC1 CHEMBL4796190 EC50 912.0 nM
C[C@@H]1CCCC[C@H]1NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5433142 IC50 914.0 nM
O=C(Nc1cccnc1)c1n[nH]c2ncc(-c3cccnc3)cc12 CHEMBL4753797 EC50 916.0 nM
COC(=O)[C@@H](NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1)C(C)O CHEMBL5401116 IC50 920.0 nM
CN1CC[C@](C)(NC2=N/C(=C\c3ccc4ncsc4c3)C(=O)N2)C1=O CHEMBL5428562 IC50 927.0 nM
COC[C@@H](CC(C)C)NC1=N/C(=C/c2ccc3ncsc3c2)C(=O)N1 CHEMBL5432405 IC50 946.8 nM
CC(C)Nc1cncc(-c2ccc3[nH]nc(-c4cc5c(-c6cccnc6)cccc5[nH]4)c3c2)c1 CHEMBL4754308 EC50 962.0 nM
O=C(Nc1ccc(OCCN2CCCC2)cc1)c1n[nH]cc1/C=C/c1cccnc1 CHEMBL4797418 EC50 967.0 nM
c1cncc(-c2cc3c(-c4nc5c(-c6cccnc6)cccc5[nH]4)n[nH]c3cn2)c1 CHEMBL4759401 EC50 969.0 nM
CN1CCN(c2cccc3[nH]c(-c4n[nH]c5ncc(-c6cncc(CN7CCCCC7)c6)cc45)cc23)CC1 CHEMBL4787864 EC50 973.0 nM
O=C(Nc1cncc(-c2ccc3[nH]nc(-c4nc5c(-c6ccncc6)ccnc5[nH]4)c3n2)c1)C1CCCCC1 CHEMBL4793590 EC50 984.0 nM
CO[C@H]1CCC[C@@H](NC2=N/C(=C\c3ccc4ncsc4c3)C(=O)N2)CC1 CHEMBL5429272 IC50 986.0 nM
O=C1NC(NC2CCC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5429595 IC50 992.0 nM
CCCC(=O)Nc1cncc(-c2ccc3[nH]nc(-c4nc5c(-c6ccncc6)cncc5[nH]4)c3n2)c1 CHEMBL4760198 EC50 995.0 nM
CO[C@H]1CCC[C@H]1NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5425381 IC50 998.0 nM
CN1CC[C@H](c2c(O)cc(O)c3c(=O)cc(-c4ccccc4Cl)oc23)[C@H](O)C1 CHEMBL428690 Kd 1000.0 nM
CCN1/C(=C\C(C)=O)Sc2ccc(OC)cc21 CHEMBL1349996 Kd 1000.0 nM
CN1C(=O)[C@@H](N2CCc3cn(Cc4ccccc4)nc3C2=O)COc2ccccc21 CHEMBL4088216 pIC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3c(nn(Cc4ccccc4)c3Br)C2=O)COc2ccccc21 CHEMBL4549667 pIC50 1000.0 nM
CN1C(=O)[C@@H](N2CCc3cn(CC4CCS(=O)(=O)CC4)nc3C2=O)COc2ccccc21 CHEMBL4097778 pIC50 1000.0 nM
CC(C)n1cnc2c(Nc3cc(N)cc(Cl)c3)nc(NC3CCCCC3N)nc21 CHEMBL5276465 IC50 1000.0 nM