NC(COc1cncc(-c2ccc3c(c2)C(=Cc2ccc[nH]2)C(=O)N3)c1)Cc1ccccc1 CHEMBL1980407 pKi 0.3162 nM
Cc1n[nH]c2ccc(-c3cncc(OC[C@@H](N)Cc4ccccc4)c3)cc12 CHEMBL379218 Kd 0.53 nM
CNc1nc(NCc2ncccn2)c2c(-c3ccc4ncccc4c3)c[nH]c2n1 CHEMBL4797564 Kd 0.61 nM
NC(=O)c1cc(-c2ccnc(N)n2)[nH]c1-c1ccc(Cl)cc1Cl CHEMBL1965660 pKi 0.631 nM
Nc1nc(Cl)cc(-c2c[nH]c3ncccc23)n1 CHEMBL2007574 pKi 0.631 nM
Cc1nc(NCc2c(F)cccc2F)c2c(-c3ccnc(N)c3)c[nH]c2n1 CHEMBL5093650 Kd 0.8 nM
NC(COc1cncc(-c2ccc3cnccc3c2)c1)Cc1c[nH]c2ccccc12 CHEMBL1981133 pKi 1.0 nM
CC(Nc1cncc(-n2cnc3ccc(C#N)cc32)n1)c1ccccc1F CHEMBL1977138 pKi 1.0 nM
NC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1973720 pKi 1.0 nM
CN1CCN(c2cc(C(=O)Nc3cc4cc(-c5cnn(C)c5)ccc4cn3)ccn2)CC1 CHEMBL4784318 IC50 1.0 nM
O=C1NC(N[C@H]2C3CC4CC2C[C@](O)(C4)C3)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5428651 IC50 1.0 nM
O=C1NC(N[C@@H](CO)c2ccccc2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5404544 IC50 1.0 nM
O=C1NC(NC2CCCSC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5405233 IC50 1.0 nM
CNCC(=O)NC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1996980 pKi 1.259 nM
N#Cc1ccc(C(=O)Nc2n[nH]c3ccc(-c4cn(Cc5ccccc5)nn4)cc23)cc1 CHEMBL1990162 pKi 1.259 nM
Nc1cc(-c2c[nH]c3ncccc23)cc(Cl)n1 CHEMBL1987448 pKi 1.585 nM
O=C(NN=Cc1cc(Br)c(O)c(Br)c1)Nc1ccccc1 CHEMBL1983575 pKi 1.585 nM
CN1CCN(C(=O)C(C)(C)c2ccc(C(=O)Nc3cn4cc(-c5ccncc5)ccc4n3)cc2)CC1 CHEMBL4531334 IC50 1.98 nM
CNC1CC2OC(C)(C1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL1980995 pKi 1.995 nM
CS(=O)(=O)NC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1980562 pKi 1.995 nM
CN(C)CC(=O)NC1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1982271 pKi 1.995 nM
Cc1n[nH]c2ccc(-c3cccnc3)cc12 CHEMBL1967252 pKi 1.995 nM
COCCN1CCN(Cc2ccc(-c3n[nH]c4c3C(=O)c3c(NC(=O)NN5CCOCC5)cccc3-4)cc2)CC1 CHEMBL3545083 Kd apparent 2.0 nM
O=C1NC(NC23CC4CC(CC(C4)C2)C3)=N/C1=C\c1ccc2[nH]cnc2c1 CHEMBL5404416 IC50 2.0 nM
O=C1NC(N[C@@H]2CCCCC[C@@H]2O)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5414514 IC50 2.0 nM
O=C1NC(NC23CC4CC(CC(O)(C4)C2)C3)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5405059 IC50 2.0 nM
COC12CC3CC(CC(NC4=N/C(=C\c5ccc6ncsc6c5)C(=O)N4)(C3)C1)C2 CHEMBL5417147 IC50 2.0 nM
CC(=O)NC12CC3CC(C1)CC(NC1=N/C(=C\c4ccc5ncsc5c4)C(=O)N1)(C3)C2 CHEMBL5422654 IC50 2.0 nM
O=C1NC(NC23CC4CC(CC(NC(=O)C5CC5)(C4)C2)C3)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5418722 IC50 2.0 nM
CS(=O)(=O)NC12CC3CC(CC(NC4=N/C(=C\c5ccc6ncsc6c5)C(=O)N4)(C3)C1)C2 CHEMBL5409574 IC50 2.0 nM
CN(C)C12CC3CC(CC(NC4=N/C(=C\c5ccc6ncsc6c5)C(=O)N4)(C3)C1)C2 CHEMBL5412565 IC50 2.0 nM
COC[C@@H](CC(C)C)NC1=N/C(=C\c2ccc3[nH]cnc3c2)C(=O)N1C CHEMBL5429691 IC50 2.1 nM
COc1ccc2sc(C(=O)N(C)Cc3cccc(F)c3)cc2c1 CHEMBL4082113 IC50 2.3 nM
CN(C)C1CCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1969151 pKi 2.512 nM
COc1cc(OC)cc(C(=O)Nc2n[nH]c3ccc(-c4cn(Cc5ccccc5)nn4)cc23)c1 CHEMBL2002613 pKi 2.512 nM
O=C(O)c1ccc2c(c1)nc(Nc1cccc(Cl)c1)c1ccncc12 CHEMBL1230165 IC50 2.6 nM
C[C@]12O[C@H](C[C@]1(O)CO)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)CNC4=O CHEMBL603469 Kd 3.0 nM
O=C1NC(NC23CC4CC(CC(C4)C2)C3)=N/C1=C\c1ccc2ncoc2c1 CHEMBL5438293 IC50 3.0 nM
Cn1cnc2ccc(/C=C3\N=C(NC45CC6CC(CC(C6)C4)C5)NC3=O)cc21 CHEMBL5420645 IC50 3.0 nM
O=C1NC(NC2CCC(F)(F)C2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5427398 IC50 3.0 nM
O=C1NC(NC2CCCCC(F)(F)C2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5396550 IC50 3.0 nM
O=C1NC(N[C@@H]2CCCC[C@@H](O)C2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5437778 IC50 3.0 nM
CO[C@@H]1CCCC[C@@H](NC2=N/C(=C\c3ccc4ncsc4c3)C(=O)N2)C1 CHEMBL5440511 IC50 3.0 nM
COC(=O)[C@@H](NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1)C(C)O CHEMBL5401116 IC50 3.0 nM
CC(C)C[C@H](CF)NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5426735 IC50 3.0 nM
O=C1NC(N[C@H]2c3ccccc3C[C@@H]2O)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5429404 IC50 3.0 nM
OCCNc1cc2cc(-c3cccnc3)ccc2cn1 CHEMBL1990912 pKi 3.162 nM
CC(C)(Nc1nccc(-c2c[nH]c3ncccc23)n1)c1ccccc1 CHEMBL1999279 pKi 3.162 nM
CCCCNc1cc(-c2ccncc2)cc2[nH]nc(N)c12 CHEMBL1983157 pKi 3.162 nM
NC(=O)c1ccc(-c2ccnc(N)n2)cc1N1CCCCC1 CHEMBL1971951 pKi 3.162 nM
NC(COc1cncc(C=Cc2ccncc2)c1)Cc1c[nH]c2ccccc12 CHEMBL1974935 pKi 3.162 nM
CS(=O)(=O)NC1CCCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)C1 CHEMBL1987948 pKi 3.162 nM
CNc1nc(C)c(-c2ccnc(Nc3ccc(N4CCNCC4)cc3)n2)s1 CHEMBL1999484 pKi 3.162 nM
Cc1nc2ccc(-c3cc(N)nc(N)c3)nc2n1C1CC1 CHEMBL4460561 K 3.2 nM
COc1ccccc1C(=O)Nc1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12 CHEMBL1997643 pKi 3.981 nM
CS(=O)(=O)NCCNc1cc(-c2c[nH]c3ncccc23)cc(Cl)n1 CHEMBL2005718 pKi 3.981 nM
N#Cc1cccc(C(=O)Nc2n[nH]c3ccc(-c4cn(Cc5ccccc5)nn4)cc23)c1 CHEMBL1977128 pKi 3.981 nM
c1ccc(CNc2nc(Nc3cc(C4CC4)[nH]n3)c3sccc3n2)cc1 CHEMBL1997924 pKi 3.981 nM
O=C1NCCc2[nH]c(-c3ccncc3)cc21 CHEMBL225519 pKi 3.981 nM
c1ccc(Cn2cc(-c3ccc4[nH]nc(-c5ccccc5)c4c3)nn2)cc1 CHEMBL1982400 pKi 3.981 nM
C=CCNc1cc(-c2c[nH]c3ncccc23)cc(Cl)n1 CHEMBL1996339 pKi 3.981 nM
Cc1nc(COc2ccccc2Cl)sc1-c1ccnc(N)n1 CHEMBL1375640 pKi 3.981 nM
CCCCNc1c(-c2ccc3[nH]ncc3c2)nc2ncccn12 CHEMBL1682554 pKi 3.981 nM
Clc1cc(Cl)cc(CNc2nccc(-c3ccc4c(c3)OCO4)n2)c1 CHEMBL2392364 IC50 4.0 nM
CCc1cc2c(cc1-c1cnn(CCCN(C)C)c1)C(C)(C)c1[nH]c3cc(C#N)ccc3c1C2=O CHEMBL3746678 IC50 4.0 nM
Cn1cnc2ccc(/C=C3\N=C(NC4CCCCCC4)NC3=O)cc21 CHEMBL5423245 IC50 4.0 nM
O=C1NC(NC23CC4CC(CC(C4)C2)C3)=N/C1=C\c1ccc2c(c1)OCO2 CHEMBL5420724 IC50 4.0 nM
O=C1NC(NC23CC4CC(CC(C4)C2)C3)=N/C1=C\c1ccc2[nH]ncc2c1 CHEMBL5405572 IC50 4.0 nM
O=C1NC(NC2CCCCC2(F)F)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5396991 IC50 4.0 nM
O=C1NC(NC2CCCC(F)(F)C2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5411888 IC50 4.0 nM
O=C1NC(N[C@@H]2CCCC[C@H](O)C2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5401675 IC50 4.0 nM
O=C1NC(N[C@@H]2CCC[C@@H](O)CC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5420497 IC50 4.0 nM
O=C1NC(N[C@H]2CCC[C@H](O)CC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5438325 IC50 4.0 nM
CO[C@@H]1CCC[C@@H](NC2=N/C(=C\c3ccc4ncsc4c3)C(=O)N2)C1 CHEMBL5440139 IC50 4.0 nM
CCOC[C@@H](CC(C)C)NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5409730 IC50 4.0 nM
CC(C)C[C@@H](CF)NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5438412 IC50 4.0 nM
O=C1NC(NC23CC4(F)CC(F)(CC(F)(C4)C2)C3)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5422486 IC50 4.0 nM
O=C1NC(NCc2ccccc2C(F)(F)F)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5430415 IC50 4.0 nM
COC[C@H](NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1)c1ccccc1 CHEMBL5439392 IC50 4.0 nM
O=C1NC(NCc2cccnc2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5395707 IC50 4.0 nM
O=C1NC(NC2COCCOC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5421636 IC50 4.0 nM
CN1CC[C@@](C)(NC2=N/C(=C\c3ccc4ncsc4c3)C(=O)N2)C1=O CHEMBL5429707 IC50 4.0 nM
Oc1ccc(-c2n[nH]c3ncc(-c4ccc(O)c(O)c4)cc23)cc1 CHEMBL4873449 IC50 4.7 nM
Cc1nc(CN(C)c2ncnc3ccc(-c4ccc5c(c4)OCO5)cc23)cs1 CHEMBL1474834 Kd 5.0 nM
CO[C@H]1CCC[C@@H]1NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5427842 IC50 5.0 nM
CO[C@H]1CCCC[C@@H](NC2=N/C(=C\c3ccc4ncsc4c3)C(=O)N2)C1 CHEMBL5422857 IC50 5.0 nM
O=C1NC(NCC(O)C2CCCCC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5436133 IC50 5.0 nM
CC(C)C[C@H](COC1CC1)NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5396386 IC50 5.0 nM
O=C1NC(NC23CC4CC(CC(F)(C4)C2)C3)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5438158 IC50 5.0 nM
O=C1NC(NC[C@@H](O)c2ccccc2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5428132 IC50 5.0 nM
COC(CNC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1)c1ccccc1 CHEMBL5424074 IC50 5.0 nM
NCC(NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1)c1ccccc1 CHEMBL5438728 IC50 5.0 nM
O=C1NC(Nc2ccccc2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5418020 IC50 5.0 nM
O=C1NC(Nc2cccnc2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5427325 IC50 5.0 nM
CC1(C)CCC(NC2=N/C(=C\c3ccc4ncsc4c3)C(=O)N2)CO1 CHEMBL5436147 IC50 5.0 nM
CC1(NC2=N/C(=C\c3ccc4ncsc4c3)C(=O)N2)CCNC1=O CHEMBL5423406 IC50 5.0 nM
COC[C@@H](CC(C)C)NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5426285 IC50 5.0 nM
CC(C)(CNc1cc(-c2c[nH]c3ncccc23)cc(Cl)n1)CNS(C)(=O)=O CHEMBL1971172 pKi 5.012 nM
NS(=O)(=O)c1cccc(Nc2ncc3ccn(-c4ccccc4)c3n2)c1 CHEMBL1988163 pKi 5.012 nM
CC(C)(CN)CNc1cc(-c2c[nH]c3ncccc23)cc(Cl)n1 CHEMBL1985723 pKi 5.012 nM
NC(COc1cncc(-c2ccc3[nH]c(=O)oc3c2)c1)Cc1c[nH]c2ccccc12 CHEMBL1987679 pKi 5.012 nM
NCCNc1cc(-c2c[nH]c3ncccc23)cc(Cl)n1 CHEMBL1972290 pKi 5.012 nM
c1ccc(CNc2cc(-c3c[nH]c4ncccc34)ncn2)cc1 CHEMBL2002346 pKi 5.012 nM
CS(=O)(=O)NCCOc1cncc(-c2ccc3cnccc3c2)c1 CHEMBL1964804 pKi 5.012 nM
O=C(NCc1ccccc1)c1c[nH]n2c(=O)cc(-c3ccncc3)nc12 CHEMBL1974250 pKi 5.012 nM
Cc1cccc(CNc2cc(-c3c[nH]c4ncccc34)cc(Cl)n2)c1C CHEMBL1988331 pKi 5.012 nM
c1ccc(Cn2nnc(-c3ccc4[nH]ncc4c3)c2-c2ccccc2)cc1 CHEMBL1969473 pKi 5.012 nM
CN(CCN)C(=O)c1cccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2cccc3ccccc23)c1 CHEMBL1979773 pKi 5.012 nM
CC(C)(O)CNc1cc(-c2c[nH]c3ncccc23)cc(Cl)n1 CHEMBL2005387 pKi 5.012 nM
NCCC(C(=O)Nc1ccc2[nH]ncc2c1)c1ccc(Cl)c(Cl)c1 CHEMBL1998121 pKi 5.012 nM
COc1ccc2c(NC(=O)Nc3cccc(Br)n3)ccnc2c1 CHEMBL1983932 pKi 5.012 nM
CC(C)C[C@H](CO)NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5412105 IC50 5.1 nM
COC[C@@H](CC(C)C)NC1=N/C(=C\c2ccc3ncoc3c2)C(=O)N1 CHEMBL5435855 IC50 5.4 nM
Cc1nc2ccc(-c3cc(N)nc(N)c3)nc2n1CC(F)(F)F CHEMBL5070553 K 5.7 nM
O=C1NC(NC23CC4CC(CC(C4)C2)C3)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5091238 IC50 6.0 nM
O=C1NC(NC2CC23CCCCC3)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5434921 IC50 6.0 nM
O=C1NC(N[C@@H]2CCC[C@H]2O)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5429789 IC50 6.0 nM
O=C1NC(N[C@@H]2CCCC[C@@H]2O)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5427523 IC50 6.0 nM
O=C1NC(N[C@@H]2CCC[C@@H](O)C2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5415622 IC50 6.0 nM
CO[C@H]1CCCC[C@@H]1NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5413743 IC50 6.0 nM
CO[C@H]1CCCCC[C@H]1NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5411157 IC50 6.0 nM
O=C1NC(N[C@H](CO)c2ccccc2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5429783 IC50 6.0 nM
O=C1NC(NCC(O)Cc2ccccc2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5398512 IC50 6.0 nM
O=C1NC(Nc2ccccn2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5417527 IC50 6.0 nM
O=C1NC(N[C@H]2CCCOC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5413726 IC50 6.0 nM
CCCC(=O)Nc1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3-c3ccccc3)cc12 CHEMBL2005936 pKi 6.31 nM
NC1CCCCC1Nc1nccc(-c2c[nH]c3ncccc23)n1 CHEMBL1995813 pKi 6.31 nM
O=C1NCCc2[nH]c(-c3ccnc(C=Cc4ccccc4)c3)cc21 CHEMBL1997129 pKi 6.31 nM
COCC(C)Nc1cc(-c2c[nH]c3ncccc23)cc(Cl)n1 CHEMBL1998068 pKi 6.31 nM
Cc1cccc(CNc2cc(-c3c[nH]c4ncccc34)ncn2)c1 CHEMBL1995932 pKi 6.31 nM
C#Cc1cn(C2CCCC2)c2ncnc(N)c12 CHEMBL1993877 pKi 6.31 nM
O=C1Nc2ccc3ncsc3c2C1=CNc1ccc(S(=O)(=O)Nc2ccccn2)cc1 CHEMBL1973540 pKi 6.31 nM
CN(C)CC(=O)NC1CCCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)C1 CHEMBL1995712 pKi 6.31 nM
Nc1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3-c3ccc(F)cc3)cc12 CHEMBL1986499 pKi 6.31 nM
CC(C)(CN)CNc1nc(Cl)cc(-c2c[nH]c3ncccc23)n1 CHEMBL1968930 pKi 6.31 nM
COc1ccc2sc(C(=O)NC(=O)c3cc(Cl)ccc3OC)cc2c1 CHEMBL5206943 IC50 6.6 nM
COC1=CC2C(=O)NC3=Cc4ccc(OC)cc4C(=C1OC)C32 CHEMBL5279705 IC50 6.7 nM
Cc1ccc([N+](=O)[O-])cc1S(=O)(=O)N(C)/N=C/c1cnc2ccc(Br)cn12 CHEMBL393525 IC50 6.9 nM
Cn1cc2cc(/C=C3\N=C(NC45CC6CC(CC(C6)C4)C5)NC3=O)ccc2n1 CHEMBL5408531 IC50 7.0 nM
O=C1NC(NC2CCCCCCC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5430192 IC50 7.0 nM
C[C@@H]1CCCC[C@H]1NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5433142 IC50 7.0 nM
O=C1NC(NC2CC3(CCC3)C2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5427895 IC50 7.0 nM
O=C1NC(N[C@H]2CC[C@H](O)CC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5422936 IC50 7.0 nM
O=C1NC(N[C@@H]2CCC[C@H](O)CC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5403037 IC50 7.0 nM
O=C1NC(N[C@@H](CO)CC2CC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5397157 IC50 7.0 nM
COC(CNC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1)C1CCCCC1 CHEMBL5423402 IC50 7.0 nM
COC(=O)[C@H](C)NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5423907 IC50 7.0 nM
COC(=O)[C@@H](NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1)C(C)C CHEMBL5416274 IC50 7.0 nM
O=C1NC(NC2C3CC4CC(C3)CC2C4)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5417207 IC50 7.0 nM
O=C1NC(NC23CC4CC(CC2C4)C3)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5400230 IC50 7.0 nM
Cc1ccc(CNC2=N/C(=C\c3ccc4ncsc4c3)C(=O)N2)c(C)c1 CHEMBL5423063 IC50 7.0 nM
O=C1NC(NC[C@H](O)c2ccccc2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5430262 IC50 7.0 nM
CC(C)(C)OC[C@H](NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1)c1ccccc1 CHEMBL5411626 IC50 7.0 nM
CN1CCN(c2ccc(NC3=N/C(=C\c4ccc5ncsc5c4)C(=O)N3)cc2)CC1 CHEMBL5397343 IC50 7.0 nM
O=C1NC(NC2CCCCOC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5424272 IC50 7.0 nM
Nc1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3-c3ccccc3)cc12 CHEMBL1972158 pKi 7.943 nM
OCC(CO)Nc1ncnc2[nH]cc(-c3ccccc3)c12 CHEMBL1992922 pKi 7.943 nM
O=C(Nc1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12)c1cccc(Cl)c1 CHEMBL1983595 pKi 7.943 nM
Cc1cc(=O)n2ccc(CN(C)C)c(O)c2n1 CHEMBL1988581 pKi 7.943 nM
CCCC(=O)Nc1cc(-c2c[nH]c3ncccc23)cc(Cl)n1 CHEMBL1998470 pKi 7.943 nM
Cc1ccccc1-c1c(-c2ccc3[nH]nc(C)c3c2)nnn1Cc1ccccc1 CHEMBL1983315 pKi 7.943 nM
C[C@@H](c1ccc(F)cc1)n1nnc2cnc3ccc(-c4ccc5ocnc5c4)cc3c21 CHEMBL4083249 IC50 8.0 nM
c1nc(N[C@H]2CC[C@H](N3CCOCC3)CC2)c2c(C3CCOCC3)c[nH]c2n1 CHEMBL4064608 IC50 8.0 nM
Cn1cnc2ccc(/C=C3\N=C(NC4CCCCC4)NC3=O)cc21 CHEMBL5394278 IC50 8.0 nM
O=C1NC(NC2CCCCCC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5283849 IC50 8.0 nM
O=C1NC(NC2CCCCCC2)=N/C1=C\c1ccc2[nH]cnc2c1 CHEMBL5408457 IC50 8.0 nM
O=C1NC(NC2CC3CCC2C3)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5412998 IC50 8.0 nM
CO[C@@H]1CCC[C@H]1NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5408907 IC50 8.0 nM
CO[C@@H]1CCCCC[C@H]1NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5428629 IC50 8.0 nM
O=C1NC(NC(CF)c2ccccc2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5404644 IC50 8.0 nM
CNCC(NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1)c1ccccc1 CHEMBL5439276 IC50 8.0 nM
O=C1NC(NCc2ccncc2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5434728 IC50 8.0 nM
O=C1NC(NC2CCOCC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5430718 IC50 8.0 nM
Brc1cc(Br)cc(CNc2nccc(-c3ccc4c(c3)OCO4)n2)c1 CHEMBL2392365 IC50 9.0 nM
O=C1NC(NC2CCCCCC2)=N/C1=C\c1ccc2c(c1)CCO2 CHEMBL5425748 IC50 9.0 nM
O=C1NC(NC2CCC(F)(F)CC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5432739 IC50 9.0 nM
O=C1NC(N[C@@H]2CCCCC[C@H]2O)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5439952 IC50 9.0 nM
CO[C@H]1CCC[C@H](NC2=N/C(=C\c3ccc4ncsc4c3)C(=O)N2)C1 CHEMBL5436754 IC50 9.0 nM
O=C1NC(N[C@@H](CO)CC2CCC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5402979 IC50 9.0 nM
COC(CNC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1)Cc1ccccc1 CHEMBL5421200 IC50 9.0 nM
NC[C@H](NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1)c1ccccc1 CHEMBL5406081 IC50 9.0 nM
NC[C@@H](NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1)c1ccccc1 CHEMBL5441121 IC50 9.0 nM
O=C1NC(NCc2ccccn2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5406568 IC50 9.0 nM
Cc1nc2ccc(-c3cc(N)nc(N)c3)nc2n1C(C)C CHEMBL4441878 IC50 9.5 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL388978 Kd 9.6 nM
Cc1c(-c2ccc3[nH]nc(N)c3c2)nnn1Cc1ccccc1 CHEMBL1989646 pKi 10.0 nM
O=C1NCCc2[nH]c(-c3ccnc(Cl)c3)cc21 CHEMBL226232 pKi 10.0 nM
CCCCOc1cc(-c2ccncc2)cc2[nH]nc(N)c12 CHEMBL1996447 pKi 10.0 nM
COc1ccc(-c2cc3nccn3c(Nc3ncccc3C(N)=O)n2)cc1OC CHEMBL1190711 pKi 10.0 nM
O=C(Nc1cc(-c2c[nH]c3ncccc23)cc(Cl)n1)c1c(F)cccc1F CHEMBL1991410 pKi 10.0 nM
COCCN(CCOC)c1cc(-c2c[nH]c3ncccc23)cc(Cl)n1 CHEMBL1985654 pKi 10.0 nM
CNCCOc1cncc(-c2ccc3[nH]nc(C)c3c2)c1 CHEMBL1983855 pKi 10.0 nM
NC(=O)c1ccc(Nc2ncnc3[nH]cc(-c4ccccc4)c23)cc1 CHEMBL1975440 pKi 10.0 nM
CCNc1nc(C)c(-c2ccnc(Nc3ccc(N4CCN(C(C)=O)CC4)cc3)n2)s1 CHEMBL1983715 pKi 10.0 nM
c1cnc2nc(-c3ccc4[nH]ncc4c3)c(NC3CCCCC3)n2c1 CHEMBL1682552 pKi 10.0 nM
Nc1n[nH]c2ccc(-c3cc(Cc4ccccc4)no3)cc12 CHEMBL1682358 pKi 10.0 nM
COc1cc(-c2ccc3[nH]nc(C(=O)Nc4ccccc4)c3c2)ccc1O CHEMBL2007002 pKi 10.0 nM
O=[N+]([O-])c1cccc(-c2nnc3ccc(N4CCCCC4)nn23)c1 CHEMBL2003637 pKi 10.0 nM
CCCC(=O)Nc1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12 CHEMBL1977223 pKi 10.0 nM
O=C(Nc1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12)c1cc(F)ccc1F CHEMBL1995811 pKi 10.0 nM
Cc1ccc(Nc2nc3ccc([N+](=O)[O-])cc3[nH]2)nc1 CHEMBL1992937 pKi 10.0 nM
N#Cc1ccc2nc(N)n(-c3nc(-c4ccccc4)cs3)c2c1 CHEMBL1996066 pKi 10.0 nM
O=C1NC(N[C@@H]2CCC[C@H](O)C2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5393925 IC50 10.0 nM
O=C1NC(NC(CO)C2CCCCC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5415462 IC50 10.0 nM
Cc1csc(CNC2=N/C(=C\c3ccc4ncsc4c3)C(=O)N2)n1 CHEMBL5434349 IC50 10.0 nM
O=C1NC(Nc2ccc(F)cc2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5424064 IC50 10.0 nM
O=C1NC(Nc2ccccc2)=N/C1=C\c1ccc2c(c1)OCO2 CHEMBL1802358 IC50 10.0 nM
CCN1/C(=C/C(C)=O)Sc2ccc(O)cc21 CHEMBL1232500 IC50 10.9 nM
O=C1NC(NC2CCCCCC2)=N/C1=C\c1ccc2ncoc2c1 CHEMBL5430824 IC50 11.0 nM
CC1(C)C2CCC1(C)[C@H](NC1=N/C(=C\c3ccc4ncsc4c3)C(=O)N1)C2 CHEMBL5412900 IC50 11.0 nM
O=C1NC(N[C@H]2CCCCC[C@@H]2O)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5423580 IC50 11.0 nM
CO[C@H]1CCC[C@@H](NC2=N/C(=C\c3ccc4ncsc4c3)C(=O)N2)C1 CHEMBL5396081 IC50 11.0 nM
CC(C)(C)NC(=O)OC12CC3CC(CC(NC4=N/C(=C\c5ccc6ncsc6c5)C(=O)N4)(C3)C1)C2 CHEMBL5421442 IC50 11.0 nM
O=C1NC(N[C@@H]2c3ccccc3C[C@H]2O)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5398161 IC50 11.0 nM
Cn1ccc(NC2=N/C(=C\c3ccc4ncsc4c3)C(=O)N2)n1 CHEMBL5407529 IC50 11.0 nM
O=C1NC(N[C@H]2CN3CCC2CC3)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5428107 IC50 11.0 nM
COC[C@@H](CC(C)C)NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1C CHEMBL5085086 IC50 11.6 nM
COC[C@@H](CC(C)C)NC1=N/C(=C\c2ccc3ncn(C)c3c2)C(=O)N1 CHEMBL5414174 IC50 11.7 nM
CN(Cc1cccs1)c1ncnc2ccc(-c3ccc4c(c3)OCO4)cc12 CHEMBL1591577 IC50 12.0 nM
Cn1cc(-c2ccc3occ(-c4cccc(-c5ccncc5)c4)c3n2)cn1 CHEMBL4754195 IC50 12.0 nM
CC1N=CC(c2ccc3occ(-c4cccc(-c5ccncc5)c4)c3n2)=N1 CHEMBL5178079 IC50 12.0 nM
O=C1NC(NC2CCCCC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5430357 IC50 12.0 nM
O=C1NC(N[C@@H](CO)CC2CCCC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5422295 IC50 12.0 nM
O=C1NC(NCC23CC4CC(CC(C4)C2)C3)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5422100 IC50 12.0 nM
O=C1NC(NC2Cc3ccccc3C2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5430988 IC50 12.0 nM
COCC(Cc1ccccc1)NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5406461 IC50 12.0 nM
O=C1NC(NCCCn2ccnc2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5398474 IC50 12.0 nM
O=C1NC(NCC2CCOCC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5425492 IC50 12.0 nM
COc1ccc(/C=C2\N=C(Nc3ccc(N4CCN(C)CC4)cc3)NC2=O)cc1O CHEMBL5416942 IC50 12.0 nM
CN1CCC(NC2=N/C(=C\c3ccc4ncsc4c3)C(=O)N2)C1=O CHEMBL5405521 IC50 12.0 nM
Nc1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3I)cc12 CHEMBL1975128 pKi 12.59 nM
CN(C)C1CCCC(Nc2nc(Cl)cc(-c3c[nH]c4ncccc34)n2)C1 CHEMBL1965702 pKi 12.59 nM
CC(C)(C)Oc1cc(-c2ccncc2)cc2[nH]nc(N)c12 CHEMBL2002456 pKi 12.59 nM
O=C(Nc1cccc(C(F)(F)F)n1)Nc1ccnc2c(F)cccc12 CHEMBL1966816 pKi 12.59 nM
CCCCC(=O)Nc1cc(-c2c[nH]c3ncccc23)cc(Cl)n1 CHEMBL2006450 pKi 12.59 nM
Nc1ncnc2c1sc1ncnc(N)c12 CHEMBL1976090 pKi 12.59 nM
CN(C)c1cc(-c2ccncc2)cc2[nH]nc(N)c12 CHEMBL2003229 pKi 12.59 nM
CC(C)Cc1cc(-c2ccc3[nH]nc(N)c3c2)on1 CHEMBL1966343 pKi 12.59 nM
O=c1cc(-c2ccncc2)nc(NCc2cc(F)cc(F)c2)[nH]1 CHEMBL2003682 pKi 12.59 nM
COc1cc(Nc2ncc([N+](=O)[O-])c(Nc3ccccc3C(N)=O)n2)cc(OC)c1OC CHEMBL1241473 pKi 12.59 nM
c1cnc2nc(-c3ccc4[nH]ncc4c3)cn2c1 CHEMBL1682540 pKi 12.59 nM
O=C(NN=Cc1ccc(O)cc1O)Nc1cccc2nsnc12 CHEMBL1999811 pKi 12.59 nM
O=C(O)c1ccccc1Nc1ccnc(Nc2ccc3[nH]ncc3c2)n1 CHEMBL396523 pKi 12.59 nM
Clc1ccc(CNc2nccc(-c3ccc4c(c3)OCCO4)n2)cc1Cl CHEMBL1904905 IC50 13.0 nM
CCN1CCN(Cc2ccc(Nc3ncc(F)c(-c4cc(F)c5nc(C)n(C(C)C)c5c4)n3)nc2)CC1 CHEMBL3301610 Kd apparent 13.0 nM
Cc1nc(Nc2n[nH]c3c2CN(C(=O)N[C@H](CN(C)C)c2ccccc2)C3(C)C)c2sccc2n1 CHEMBL3128043 Kd apparent 13.0 nM
C[C@@H]1[C@H]2C[C@@H](C[C@H]1NC1=N/C(=C\c3ccc4ncsc4c3)C(=O)N1)C2(C)C CHEMBL5416470 IC50 13.0 nM
O=C1NC(NCc2ccccc2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5405969 IC50 13.0 nM
O=C1NC(Nc2cncnc2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5407276 IC50 13.0 nM
O=C1NC(N[C@H]2CCOC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5424363 IC50 13.0 nM
O=C1NC(N[C@@H]2COCC[C@H]2O)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5431345 IC50 13.0 nM
COc1ccc2sc(C(=O)NNc3cc(Cl)cc(Cl)c3)cc2c1 CHEMBL5424844 IC50 13.4 nM
COC[C@@H](CC(C)C)NC1=N/C(=C\c2ccc3c(c2)OCO3)C(=O)N1 CHEMBL5428750 IC50 13.5 nM
CC(C)C[C@@H](CO)NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5408047 IC50 13.5 nM
CCN(Cc1cccs1)c1ncnc2ccc(-c3ccc4c(c3)OCO4)cc12 CHEMBL1515144 IC50 14.0 nM
Clc1ccc(CNc2nccc(-c3ccc4c(c3)OCO4)n2)cc1Cl CHEMBL1898197 IC50 14.0 nM
CCc1cc2c(cc1-c1cnn(CC(=O)N(C)C)c1)C(C)(C)c1[nH]c3cc(C#N)ccc3c1C2=O CHEMBL3735401 IC50 14.0 nM
O=C(Nc1ccc2[nH]cnc2c1)c1csc(Nc2ccccc2)n1 CHEMBL5185809 IC50 14.0 nM
O=C1N=C(Nc2c(Cl)cccc2Cl)S/C1=C\c1ccc2nccnc2c1 CHEMBL5081787 IC50 14.0 nM
Cc1ccc(CNC2=N/C(=C\c3ccc4ncsc4c3)C(=O)N2)cc1C CHEMBL5413503 IC50 14.0 nM
O=C1NC(N[C@@H](CO)Cc2ccccc2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5435490 IC50 14.0 nM
CO[C@@H]1Cc2ccccc2[C@H]1NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5414635 IC50 14.0 nM
O=C1NC(NC2COC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5412372 IC50 14.0 nM
O=C1NC(N[C@@H]2CCCOC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5397281 IC50 14.0 nM
COC[C@@H](CC(C)C)NC1=N/C(=C\c2ccc3c(c2)CCO3)C(=O)N1 CHEMBL5395833 IC50 14.0 nM
Cn1cc(-c2ccc3cnc(NC(=O)C4CCN(S(C)(=O)=O)CC4)cc3c2)cn1 CHEMBL5285332 IC50 14.1 nM
CCOC(=O)c1c(/C(C#N)=C\N)c2ccc(Cl)c(Cl)c2n1C CHEMBL1236620 IC50 14.8 nM
Cc1ccc(CNc2ncnc3ccc(-c4ccc5c(c4)OCO5)cc23)o1 CHEMBL1473127 IC50 15.0 nM
COC(=O)[C@@]1(O)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL281948 Kd apparent 15.0 nM
Cn1cc(-c2ccc3occ(-c4cccc(-c5cc[nH]n5)c4)c3n2)cn1 CHEMBL4762964 IC50 15.0 nM
c1ccc(-c2ccc3[nH]ncc3c2)cc1 CHEMBL3298236 IC50 15.0 nM
O=C1NC(N[C@H]2CCCC[C@H]2O)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5429703 IC50 15.0 nM
CO[C@H]1CCC[C@@H](NC2=N/C(=C\c3ccc4ncsc4c3)C(=O)N2)CC1 CHEMBL5429272 IC50 15.0 nM
OC(COc1cncc(C=Cc2ccncc2)c1)Cc1c[nH]c2ccccc12 CHEMBL1993584 pKi 15.85 nM
N#Cc1ccc(-c2ccncc2)cc1NCc1ccccc1 CHEMBL1967992 pKi 15.85 nM
O=C(Nc1nc2ccccc2n1CCCO)c1cccc([N+](=O)[O-])c1 CHEMBL210887 pKi 15.85 nM
CNC(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCOCC3)cc2OC)ncc1Cl CHEMBL458997 pKi 15.85 nM
NC(=O)c1cccc(-c2cnc3[nH]cc(-c4ccccc4)c3c2)c1 CHEMBL1982957 pKi 15.85 nM
O=C(NCCc1cccs1)N1CC=C(c2c[nH]c3ncccc23)CC1 CHEMBL1987535 pKi 15.85 nM
COc1ccc2c(NC(=O)Nc3cc(C(F)(F)F)ccn3)ccnc2c1 CHEMBL1979176 pKi 15.85 nM
Nc1ncnc2c1c(I)nn2C1CCC(O)CC1 CHEMBL1996791 pKi 15.85 nM
CCN1CCN(c2ccc(Nc3ncc(C#N)c(Nc4ccc5[nH]ncc5c4)n3)cc2)CC1 CHEMBL1973516 pKi 15.85 nM
CCCNC(=O)c1ccc(Nc2nc(NCC(F)(F)F)c3cc[nH]c3n2)cc1 CHEMBL2006765 pKi 15.85 nM
c1cncc(CNc2nccc(-c3ccc4c(c3)OCO4)n2)c1 CHEMBL1877990 IC50 16.0 nM
CO[C@@H]1CCCC[C@H]1NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5394394 IC50 16.0 nM
COC(=O)[C@H](Cc1ccccc1)NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5434955 IC50 16.0 nM
O=C1NC(Nc2cccc(OC(F)F)c2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5409693 IC50 16.0 nM
CN1CCN(c2ccc(NC3=N/C(=C\c4ccc5c(c4)OCO5)C(=O)N3)cc2)CC1 CHEMBL5179655 IC50 16.0 nM
COC[C@@H](CC(C)C)NC1=N/C(=C/c2ccc3ncoc3c2)C(=O)N1C CHEMBL5401556 IC50 16.3 nM
Cn1cc(-c2cccc(-c3coc4ccc(-c5cnn(C)c5)nc34)c2)cn1 CHEMBL4797457 IC50 17.0 nM
COc1ccc(CNC(=O)c2cnc3ccc(-c4ccc5ncccc5c4)cn23)cc1 CHEMBL4853178 IC50 17.0 nM
COC(=O)[C@H](CC(C)C)NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5428794 IC50 17.0 nM
O=C1NC(=S)S/C1=C\c1ccc2ncccc2c1 CHEMBL3774448 IC50 17.8 nM
COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(N(C)C(=O)CN2CCN(C)CC2)cc1)c1ccccc1 CHEMBL502835 Kd 18.0 nM
Brc1ccc(CNc2nccc(-c3ccc4c(c3)OCO4)n2)cc1Br CHEMBL1899256 IC50 18.0 nM
CNC(=O)c1nn(C)c2c1C(C)(C)Cc1cnc(Nc3ccc(N4CCN(C)CC4)cc3)nc1-2 CHEMBL564829 Kd apparent 18.0 nM
CO[C@H]1CCC[C@H](NC2=N/C(=C\c3ccc4ncsc4c3)C(=O)N2)CC1 CHEMBL5396280 IC50 18.0 nM
CN1CCN(c2ncc(NC3=N/C(=C\c4ccc5ncsc5c4)C(=O)N3)cn2)CC1 CHEMBL5407057 IC50 18.0 nM
COC[C@@H](CC(C)C)NC1=N/C(=C/c2ccc3ncsc3c2)C(=O)N1 CHEMBL5432405 IC50 18.9 nM
Cn1cc(-c2ccc3occ(-c4cccc(-c5cn[nH]c5)c4)c3n2)cn1 CHEMBL4789951 IC50 19.0 nM
CC(=O)OC12CC3CC(CC(NC4=N/C(=C\c5ccc6ncsc6c5)C(=O)N4)(C3)C1)C2 CHEMBL5412101 IC50 19.0 nM
CN1CCN(c2ccc(NC3=N/C(=C\c4ccc5c(c4)OCCO5)C(=O)N3)cc2)CC1 CHEMBL5414801 IC50 19.0 nM
CCCCNc1cc(-c2c[nH]c3ncccc23)ncn1 CHEMBL1968459 pKi 19.95 nM
COc1cc2c(cc1Nc1nc(Nc3cccc(F)c3C(N)=O)c3cc[nH]c3n1)N(C(=O)CN(C)C)CC2 CHEMBL461876 pKi 19.95 nM
O=c1cc(-c2ccncc2)nc(NC2CCCCC2)[nH]1 CHEMBL1958401 pKi 19.95 nM
CCCC(=O)Nc1n[nH]c2ccc(-c3cccc(F)c3F)cc12 CHEMBL1985406 pKi 19.95 nM
CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCNCC4)cn3)nc2n(C2CCCC2)c1=O CHEMBL189963 pKi 19.95 nM
NC(=O)c1cc2c(-c3ccc(Nc4nc5ccccc5o4)cc3)cnc(N)c2s1 CHEMBL1993904 pKi 19.95 nM
NC(=O)c1cn(-c2ccc(O)cc2Cl)c2cc(-c3ccncc3)ccc2c1=O CHEMBL340384 pKi 19.95 nM
OCCCNc1ncnc2[nH]cc(-c3ccccc3)c12 CHEMBL2000071 pKi 19.95 nM
COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 CHEMBL509032 pKi 19.95 nM
OC1CCC(Nc2cc(Cl)nc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1991674 pKi 19.95 nM
CCOc1ccc(C=C2SC(=N)NC2=O)c(O)c1 CHEMBL1971289 pKi 19.95 nM
NC(=O)c1ccc2nc(-c3ccc([N+](=O)[O-])o3)cn2c1 CHEMBL1973359 pKi 19.95 nM
O=C(Nc1cnccn1)Nc1ccnc2ccc(C(F)(F)F)cc12 CHEMBL1976455 pKi 19.95 nM
CN(Cc1nccs1)c1ncnc2ccc(-c3ccc4c(c3)OCO4)cc12 CHEMBL1396483 IC50 20.0 nM
Cc1ccc(-n2cc(COc3cccc4cnc(Nc5cccc(Cl)c5)nc34)nn2)c([N+](=O)[O-])c1 CHEMBL4783398 IC50 20.0 nM
O=[N+]([O-])c1ccccc1-n1cc(COc2cccc3cnc(Nc4cccc(Cl)c4)nc23)nn1 CHEMBL5282544 IC50 20.0 nM
O=C1NC(NC2CCCCCC2)=N/C1=C\c1ccc2c(c1)OCO2 CHEMBL5410991 IC50 20.0 nM
Cc1nc2ccc(/C=C3\N=C(NC45CC6CC(CC(C6)C4)C5)NC3=O)cc2s1 CHEMBL5407040 IC50 20.0 nM
COc1ccc2[nH]c3c(=O)[nH]c(-c4cccnc4)c(C#N)c3c2c1 CHEMBL3885036 IC50 21.0 nM
O=C1NC(NC2CCCCC2)=N/C1=C\c1ccc2ncoc2c1 CHEMBL5394477 IC50 21.0 nM
CC(=O)N1CCc2ccc(NC3=N/C(=C\c4ccc5ncsc5c4)C(=O)N3)cc21 CHEMBL5433644 IC50 21.0 nM
CC(C)Oc1ccc(F)c(-c2cnc(N)c(C(=O)Nc3cnccc3N3CCC[C@@H](C(=O)O)C3)n2)c1 CHEMBL4647659 IC50 21.1 nM
CCNc1cc(Nc2ccc(C(=O)N3CCC(N4CCOCC4)CC3)cc2OC)nc2[nH]cc(C(F)(F)F)c12 CHEMBL5273528 IC50 21.1 nM
COc1ccc2sc(C(=O)NNc3cc(F)cc(F)c3)cc2c1 CHEMBL5424488 IC50 21.1 nM
COc1ccc2[nH]cc(-c3cc4cnccc4cc3NC(C)=O)c2c1 CHEMBL3885335 IC50 22.0 nM
O=C1NC(NC23CC4CC(CC(C4)C2)C3)=N/C1=C\c1ccc2nnsc2c1 CHEMBL5434048 IC50 22.0 nM
O=C1CC[C@H](NC2=N/C(=C\c3ccc4ncsc4c3)C(=O)N2)CN1 CHEMBL5433242 IC50 22.0 nM
O=C1NC(NC2CCC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5429595 IC50 23.0 nM
O=C1NC(NC2CCCC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5439694 IC50 23.0 nM
O=C1NC(N[C@@H]2CCOC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5425635 IC50 23.0 nM
COc1ccc2c3ccnc(Cl)c3n(CC#N)c2c1 CHEMBL4283240 IC50 23.8 nM
CC(C)CN1CCC(C(=O)Nc2cc3cc(-c4cnn(C)c4)ccc3cn2)CC1 CHEMBL5289681 IC50 23.8 nM
COc1ccc2c(c1)[nH]c1c(C)nccc12 CHEMBL269538 IC50 24.0 nM
CO[C@H]1CC[C@H](NC2=N/C(=C\c3ccc4ncsc4c3)C(=O)N2)CC1 CHEMBL5429086 IC50 24.0 nM
Cc1ccc(CNC2=N/C(=C\c3ccc4ncsc4c3)C(=O)N2)o1 CHEMBL5439185 IC50 24.0 nM
CC(C)n1cnc2c(Nc3cc(N)cc(Cl)c3)nc(N[C@@H]3CCCC[C@@H]3N)nc21 CHEMBL4078898 IC50 25.0 nM
CC(C)n1cnc2c(Nc3cc(N)cc(Cl)c3)nc(NC3CCCCC3N)nc21 CHEMBL5276465 IC50 25.0 nM
CC[C@H](CO)NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5426049 IC50 25.0 nM
CC(C)C[C@H](COC(C)(C)C)NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5398683 IC50 25.0 nM
COc1ccccc1CNc1ncnc2ccc(-c3ccc4c(c3)OCO4)cc12 CHEMBL1516054 Potency 25.1 nM
O=C1Nc2ccccc2Nc2cc(-c3ccncc3F)ccc21 CHEMBL1989293 pKi 25.12 nM
O=C(Nc1cc(-c2c[nH]c3ncccc23)cc(Cl)n1)c1ccccc1 CHEMBL1993413 pKi 25.12 nM
CN1c2ccc(N)cc2C(c2ccccc2)c2cc(N)ccc21 CHEMBL1991734 pKi 25.12 nM
CCCCN(CCC#N)C(=O)c1ccc2nc(-c3n[nH]c4ccccc34)[nH]c2c1 CHEMBL1983348 pKi 25.12 nM
NC1CCC(Nc2cc(Cl)nc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL1983589 pKi 25.12 nM
CCN1CCN(c2ccc(Nc3ncc(Cl)c(Nc4ccc5[nH]ncc5c4)n3)cc2)CC1 CHEMBL1967998 pKi 25.12 nM
Oc1cnc2ccc(-c3ccncc3)cc2c1 CHEMBL1973868 pKi 25.12 nM
COc1cc(C=C2SC(=S)NC2=O)ccc1O CHEMBL1973098 pKi 25.12 nM
CCOC(=O)c1c[nH]n2c(=O)cc(-c3ccncc3)nc12 CHEMBL1990708 pKi 25.12 nM
COc1ccc2c(NC(=O)Nc3cccc(C(F)(F)F)n3)ccnc2c1 CHEMBL1982660 pKi 25.12 nM
C=CCc1cccc2c(=NO)cc(-c3ccccc3)oc12 CHEMBL1977749 pKi 25.12 nM
COc1ccc(C=C2SC(=Nc3ccccc3)NC2=O)cc1O CHEMBL2000354 pKi 25.12 nM
Nc1n[nH]c2ccc(-c3nnn(Cc4ccccc4)c3C3CC3)cc12 CHEMBL2004631 pKi 25.12 nM
NC(=O)Cn1cc(-c2cc(-c3cc4ccccc4s3)c3[nH]ncc3c2)c2nc(N)ncc21 CHEMBL1985095 pKi 25.12 nM
Cc1ccccc1-c1c(-c2ccc3[nH]nc(N)c3c2)nnn1Cc1ccccc1 CHEMBL2000029 pKi 25.12 nM
CN(C)CC(=O)NC(COc1cncc(-c2ccc3cnccc3c2)c1)Cc1c[nH]c2ccccc12 CHEMBL1991725 pKi 25.12 nM
CNS(=O)(=O)c1ccccc1Nc1nc(Nc2cc(N3CCN(C(C)=O)CC3)ccc2OC)ncc1Br CHEMBL1971029 pKi 25.12 nM
CN1CCN(c2ccc(Nc3ncc(Cl)c(Nc4ccc5[nH]ncc5c4)n3)cc2)CC1 CHEMBL1979690 pKi 25.12 nM
Nc1n[nH]c2cccc(-c3ccc(NC(=O)Nc4cc(C(=O)O)ccc4F)cc3)c12 CHEMBL1993722 pKi 25.12 nM
CNS(=O)(=O)c1ccccc1Nc1nc(Nc2cc(OC)c(OC)c(OC)c2)ncc1Cl CHEMBL1993661 pKi 25.12 nM
O=C1NC(N[C@@H](CO)CC2CCCCC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5431535 IC50 26.0 nM
COc1nc(C)ccc1NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5413447 IC50 26.0 nM
COC[C@@H](CC(C)C)NC1=N/C(=C\c2ccc3ncsc3n2)C(=O)N1 CHEMBL5429359 IC50 26.4 nM
CC[C@@H](CO)Nc1ccc2ncc(-c3cccc(NC(C)=O)c3)n2n1 CHEMBL4061526 IC50 27.0 nM
O=C1NC(N[C@@H]2CCCC[C@H]2O)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5417693 IC50 27.0 nM
COC[C@H](CC(C)C)NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5403642 IC50 27.0 nM
CN1CCCC(NC2=N/C(=C\c3ccc4ncsc4c3)C(=O)N2)C1=O CHEMBL5413138 IC50 27.0 nM
CC(C)n1cnc2c(Nc3cc(N)cc(Cl)c3)nc(N[C@H]3CCCC[C@H]3N)nc21 CHEMBL4104657 IC50 28.0 nM
COC[C@@H](NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1)c1ccccc1 CHEMBL5401217 IC50 28.0 nM
CC1(C)CNC(=O)C1NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5411344 IC50 28.0 nM
CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C CHEMBL535 Kd 29.0 nM
Cc1ccsc1CN(C)c1ncnc2ccc(-c3ccc4c(c3)OCO4)cc12 CHEMBL1318637 IC50 29.0 nM
c1nc(NCC2CCCO2)c2cc(-c3ccc4c(c3)OCO4)ccc2n1 CHEMBL1552755 IC50 29.0 nM
O=C1NC(N[C@@H]2CCC[C@@H]2O)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5423395 IC50 29.0 nM
CN1CCN(c2cnc(NC3=N/C(=C\c4ccc5ncsc5c4)C(=O)N3)cn2)CC1 CHEMBL5426807 IC50 29.0 nM
CCN1/C(=C/C(C)=O)Sc2ccc(OC)cc21 CHEMBL408982 Kd 30.0 nM
c1nc(NCC2CCOC2)c2cc(-c3ccc4c(c3)OCO4)ccc2n1 CHEMBL1436585 Kd 30.0 nM
c1cncc(CNc2nccc(-c3ccc4[nH]ncc4c3)n2)c1 CHEMBL1902528 IC50 30.0 nM
Clc1ccc(CNc2nccc(-c3ccc4[nH]ncc4c3)n2)cc1Cl CHEMBL1892019 IC50 30.0 nM
COc1ccc2c(c1)[nH]c1c3c(OC)cncc3cc(C#N)c21 CHEMBL3884821 IC50 30.0 nM
CC(=O)Nc1cc(Cl)cc(Nc2nc(N[C@@H]3CCCC[C@@H]3N)nc3c2ncn3C(C)C)c1 CHEMBL4094492 IC50 30.0 nM
O=C1NC(N[C@H]2COCC[C@@H]2O)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5396752 IC50 30.0 nM
CC(=O)Nc1cc(Cl)cc(Nc2nc(N[C@H]3CCCC[C@H]3N)nc3c2ncn3C(C)C)c1 CHEMBL4067013 IC50 31.0 nM
c1ccc2cc(-c3coc4ccc(-c5cn[nH]c5)nc34)ccc2c1 CHEMBL4750420 IC50 31.0 nM
O=C1NC(Nc2nncs2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5424295 IC50 31.0 nM
Cn1c(=O)n(-c2ccc(C(C)(C)C#N)cc2)c2c3cc(-c4cnc5ccccc5c4)ccc3ncc21 CHEMBL1879463 pKi 31.62 nM
OCc1cc(-c2ccc3[nH]ncc3c2)on1 CHEMBL1974617 pKi 31.62 nM
COc1cc(C=C2SC(=Nc3ccccc3)NC2=O)ccc1O CHEMBL1970522 pKi 31.62 nM
Cn1cc(-c2ccccc2)c2nc(-c3ccncc3)cc(=O)n21 CHEMBL1986767 pKi 31.62 nM
NC1CCCCC1Nc1nc(Cl)cc(-c2c[nH]c3ncccc23)n1 CHEMBL1994438 pKi 31.62 nM
CC(C)Nc1c(-c2ccc3[nH]ncc3c2)nc2ncccn12 CHEMBL1682553 pKi 31.62 nM
NCCCn1cc(-c2cc(-c3cc4ccccc4s3)c3[nH]ncc3c2)c2nc(N)ncc21 CHEMBL592030 pKi 31.62 nM
COc1cccc(C(C)NC(=O)c2cc(C)c(-c3ccc4[nH]nc(C)c4c3)s2)c1 CHEMBL1997534 pKi 31.62 nM
N#Cc1ccc2c(c1)C(c1ccc3c(n1)CCCC3O)C(=O)N2 CHEMBL1985681 pKi 31.62 nM
CC(C)(C)Nc1ncnc2[nH]cc(-c3ccccc3)c12 CHEMBL1995211 pKi 31.62 nM
c1cc2[nH]ncc2cc1-c1cn(CC2CCOCC2)nn1 CHEMBL1969843 pKi 31.62 nM
Nc1ncnc2c1c(I)nn2C1OC(CO)C(O)C1O CHEMBL2001288 pKi 31.62 nM
Nc1nnc(-c2cc3c(Oc4ccc(Cl)cc4)cncc3s2)o1 CHEMBL1994830 pKi 31.62 nM
c1ccc(CNc2nc3ccc(-c4ccncc4)cc3s2)cc1 CHEMBL1983534 pKi 31.62 nM
O=C1NC(=S)S/C1=C\c1ccc2ncsc2c1 CHEMBL3775393 IC50 31.8 nM
COC(=N)c1nc2ccc3ncnc(Nc4ccc(OC)cc4F)c3c2s1 CHEMBL3894571 IC50 32.0 nM
CO[C@H]1CCCC[C@H]1NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5395027 IC50 32.0 nM
Cc1cnc(CNC2=N/C(=C\c3ccc4ncsc4c3)C(=O)N2)cn1 CHEMBL5422096 IC50 32.0 nM
COc1ccc2c(c1)[nH]c1c3ccncc3cc(C#N)c21 CHEMBL3883660 IC50 33.0 nM
O=C1NC(NC2CCNC2=O)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5429357 IC50 33.0 nM
c1c[nH]c(CNc2ncnc3ccc(-c4ccc5c(c4)OCO5)cc23)n1 CHEMBL1407164 IC50 34.0 nM
Cc1nc2ccc(/C=C3\N=C(NC4CCCCCC4)NC3=O)cc2s1 CHEMBL5435753 IC50 34.0 nM
COC(=O)[C@@H](CC(C)C)NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5405680 IC50 34.0 nM
O=C1NC(NCCc2ccccn2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5401073 IC50 34.0 nM
O=C1NC(Nc2ncccn2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5409992 IC50 34.0 nM
Cc1ccsc1CNc1ncnc2ccc(-c3ccc4c(c3)OCO4)cc12 CHEMBL1396654 IC50 35.0 nM
O=C1NC(NC2CCCNC2=O)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5401201 IC50 35.0 nM
c1ccc(CNc2ncnc3ccc(-c4ccc5c(c4)OCO5)cc23)cc1 CHEMBL1358796 Potency 35.5 nM
CN(Cc1ccco1)c1ncnc2ccc(-c3ccc4c(c3)OCO4)cc12 CHEMBL1374544 IC50 36.0 nM
C[C@@H](NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1)C1CCCCC1 CHEMBL5430485 IC50 36.0 nM
Cc1csc(CN(C)c2ncnc3ccc(-c4ccc5c(c4)OCO5)cc23)n1 CHEMBL1704879 IC50 37.0 nM
O=C1NC(NC2CCCCC2)=N/C1=C\c1ccc2[nH]cnc2c1 CHEMBL5437222 IC50 37.0 nM
O=C1NC(NCc2ccccc2OC(F)(F)F)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5431414 IC50 37.0 nM
COC[C@@H](CC(C)C)NC1=N/C(=C\c2ccc3ncn(C)c3c2)C(=O)N1C CHEMBL5397088 IC50 37.0 nM
c1nc(NCc2ccoc2)c2cc(-c3ccc4c(c3)OCO4)ccc2n1 CHEMBL566900 IC50 38.0 nM
c1csc(CNc2ncnc3ccc(-c4ccc5c(c4)OCO5)cc23)c1 CHEMBL567331 IC50 39.0 nM
CC[C@@H](CO)NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5437946 IC50 39.0 nM
Cc1nc2cnc(Nc3ccccc3)nc2n(CCc2ccccc2)c1=O CHEMBL1552588 Potency 39.8 nM
CSc1c[nH]c2ncnc(NCCCO)c12 CHEMBL2000114 pKi 39.81 nM
Nc1n[nH]c2cccc(-c3ccc(F)cc3)c12 CHEMBL1971519 pKi 39.81 nM
CCC(=O)Nc1ccc(C(=O)N2CCNCC2)c(O)c1 CHEMBL1988141 pKi 39.81 nM
Fc1cccc(-c2c[nH]c3ncccc23)c1 CHEMBL1993648 pKi 39.81 nM
OC1CCCC(Nc2cc(Cl)nc(-c3c[nH]c4ncccc34)n2)C1 CHEMBL1976936 pKi 39.81 nM
O=C(Nc1cnccn1)Nc1ccnc2cc(C(F)(F)F)ccc12 CHEMBL2003817 pKi 39.81 nM
O=C1Nc2ccccc2Nc2cc(-c3ccncc3)ccc21 CHEMBL1989136 pKi 39.81 nM
Cc1nc(CNc2ncnc3ccc(-c4ccc5c(c4)OCO5)cc23)cs1 CHEMBL1435542 IC50 40.0 nM
c1cncc(CNc2nccc(-c3ccc4cn[nH]c4c3)n2)c1 CHEMBL1894742 IC50 40.0 nM
COc1cccc2c1[nH]c1c3ccncc3cc(C#N)c21 CHEMBL3885431 IC50 40.0 nM
c1ccc(-c2coc3ccc(-c4cn[nH]c4)nc23)cc1 CHEMBL4790030 IC50 41.0 nM
COC[C@@H](CC(C)C)NC1=N/C(=C\c2ccc3[nH]cnc3c2)C(=O)N1 CHEMBL5417699 IC50 41.2 nM
c1coc(CCNc2ncnc3ccc(-c4ccc5c(c4)OCO5)cc23)c1 CHEMBL1357975 IC50 42.0 nM
FC(F)(F)c1cccc(Nc2nccc(-c3ccc4c(c3)OCO4)n2)c1 CHEMBL1868723 IC50 42.0 nM
C=C(C)c1ccc(-c2coc3ccc(-c4cn[nH]c4)nc23)cc1 CHEMBL4743730 IC50 42.0 nM
O=C1NC(NC2CCCCC2)=N/C1=C\c1ccc2c(c1)OCO2 CHEMBL5395680 IC50 43.0 nM
CN1CC[C@](C)(NC2=N/C(=C\c3ccc4ncsc4c3)C(=O)N2)C1=O CHEMBL5428562 IC50 43.0 nM
CO[C@H]1CCC[C@H]1NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5425381 IC50 44.0 nM
c1cncc(CNc2ccnc(-c3ccc4c(c3)OCO4)n2)c1 CHEMBL1357018 Potency 44.7 nM
Cc1nnc(CN(C)c2ncnc3ccc(-c4ccc5c(c4)OCO5)cc23)o1 CHEMBL1437638 IC50 45.0 nM
Cn1cc(-c2coc3ccc(-c4cn[nH]c4)nc23)cn1 CHEMBL4790791 IC50 45.0 nM
O=C(O)c1nc2ccccc2c2[nH]c3c(Cl)cccc3c12 CHEMBL3589660 IC50 45.0 nM
COc1ccc(-c2coc3ccc(-c4cn[nH]c4)nc23)cc1 CHEMBL4743939 IC50 46.0 nM
COc1cc(Nc2nccc(-c3cnn4nc(OC)ccc34)n2)cc(C(F)(F)F)c1 CHEMBL187139 IC50 46.0 nM
Cc1occc1CNc1ncnc2ccc(-c3ccc4c(c3)OCO4)cc12 CHEMBL1476499 IC50 47.0 nM
N#C/C(=C\c1cccnc1)c1c[nH]c2ncccc12 CHEMBL3753668 IC50 47.0 nM
COc1ccc2c(n1)[nH]c1c3ccncc3cc(C#N)c21 CHEMBL3885316 IC50 47.0 nM
O=C(c1ccc(/C=C/c2n[nH]c3ccccc23)cc1)N1CCNCC1 CHEMBL1908397 Kd 49.0 nM
CN1CCN(C(=O)C(C)(C)c2ccc(C(=O)Cc3cn4cc(-c5ccncc5)ccc4n3)cc2)CC1 CHEMBL5288391 IC50 49.1 nM
c1csc(CNc2ncnc3ccc(-c4ccc5c(c4)OCO5)cc23)n1 CHEMBL1705549 IC50 50.0 nM
Clc1ccc(CNc2nccc(-c3ccc4c(c3)OCO4)n2)cc1 CHEMBL2392363 IC50 50.0 nM
CC(C)n1cnc2c(Nc3cccc(Cl)c3)nc(N[C@@H]3CCCC[C@@H]3N)nc21 CHEMBL4066861 IC50 50.0 nM
CN(Cc1ccco1)c1ncnc2ccc(-c3ccoc3)cc12 CHEMBL1332033 Potency 50.1 nM
c1csc(CNc2ncnc3ccc(-c4ccoc4)cc23)c1 CHEMBL1410859 Potency 50.1 nM
COc1cccc(Nc2ncc3ncc(=O)n(CCc4ccccc4)c3n2)c1 CHEMBL1407035 Potency 50.1 nM
Cc1cc(N2CCOCC2)cc2[nH]c(-c3c(NCC(O)c4cccc(Cl)c4)cc[nH]c3=O)nc12 CHEMBL2005886 pKi 50.12 nM
NCCCOc1cc2c(c(-c3ccc(Nc4nc5ccc(Cl)cc5o4)cc3)c1)CNC2=O CHEMBL2002479 pKi 50.12 nM
Nc1ncnc2sc3c(c12)-c1ccc(NC(=O)Nc2ccccc2)cc1CC3 CHEMBL1994693 pKi 50.12 nM
O=c1[nH]cc(I)c2nc(-c3cccc(Cl)c3)cn12 CHEMBL1982610 pKi 50.12 nM
CN(Cc1cc(Cl)c(O)c2ncccc12)C1CCCCC1 CHEMBL1982413 pKi 50.12 nM
O=C(O)c1ccccc1Nc1ccnc(Nc2cccc(F)c2)n1 CHEMBL243298 pKi 50.12 nM
O=C(Nc1ccc2[nH]ncc2c1)c1ccc(Cl)cc1 CHEMBL1973808 pKi 50.12 nM
c1nc(-c2ccc3c(c2)OCO3)c2cc[nH]c2n1 CHEMBL2004515 pKi 50.12 nM
Cn1cc(-c2ccc3occ(-c4cccc(C5CCNCC5)c4)c3n2)cn1 CHEMBL4791451 IC50 52.0 nM
O=C1NC(NC2CCCCC2)=N/C1=C\c1ccc2c(c1)CCO2 CHEMBL5419006 IC50 52.0 nM
COC[C@@H](CC(C)C)NC1=N/C(=C\c2ccc3nc(C)sc3c2)C(=O)N1 CHEMBL5435195 IC50 52.7 nM
Cn1cc2cc(/C=C3\N=C(NC4CCCCCC4)NC3=O)ccc2n1 CHEMBL5425792 IC50 55.0 nM
COc1ccc2[nH]c3c4ccncc4cc(C#N)c3c2c1 CHEMBL3883639 IC50 57.0 nM
CCN1C(=O)/C(=C/c2ccc3ncsc3c2)N=C1N[C@@H](COC)CC(C)C CHEMBL5433334 IC50 58.5 nM
COC(=N)c1nc2ccc3ncnc(Nc4ccc(Cl)cc4Cl)c3c2s1 CHEMBL2386747 IC50 59.0 nM
CNC(=O)c1c(F)cccc1Nc1nc(Nc2cc3c(cc2OC)CCN3C(=O)CN(C)C)nc2[nH]ccc12 CHEMBL464552 Kd 60.0 nM
CC(C)n1cnc2c(Nc3cc(N)cc(Cl)c3)nc(N[C@H]3CCCNC3)nc21 CHEMBL4064123 IC50 61.0 nM
CN(C)c1nccc(-c2cnn3ncccc23)n1 CHEMBL4848254 Kd 61.0 nM
O=C1NC(NC2CC2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5400270 IC50 61.0 nM
Cc1ccnc(Nc2cc(C)nc(-c3ccccc3)n2)c1 CHEMBL1985367 pKi 63.1 nM
COc1ccc(C2=NNc3cccc4c(OC)ccc2c34)cc1OC CHEMBL1997335 pKi 63.1 nM
CC(=O)Nc1cccc(CNc2c(Nc3ccc4[nH]ncc4c3)c(=O)c2=O)c1 CHEMBL1988608 pKi 63.1 nM
NCC(O)C(O)Cn1cc(I)c2c(N)ncnc21 CHEMBL1975534 pKi 63.1 nM
CNC(=O)C=Cc1cnc(N)c2c(-c3cc(F)c4[nH]c(C)cc4c3)csc12 CHEMBL2006778 pKi 63.1 nM
Cc1cc(-c2ccc3c(c2)Nc2ccccc2NC3=O)ccn1 CHEMBL1981511 pKi 63.1 nM
Oc1c2ccccc2c2c3c(cccc13)N=N2 CHEMBL1725279 pKi 63.1 nM
FC(F)(F)c1cccc(CNc2cc(-c3c[nH]c4ncccc34)ncn2)c1 CHEMBL1966040 pKi 63.1 nM
CCn1c(-c2nonc2N)nc2cncc(C(=O)N3CCC(N)C3)c21 CHEMBL1870106 pKi 63.1 nM
CN(c1ncccc1CNc1nc(Nc2ccc3c(c2)CC(=O)N3)ncc1C(F)(F)F)S(C)(=O)=O CHEMBL1084546 pKi 63.1 nM
Cc1cc(O)ccc1-n1cc(C(N)=O)c(=O)c2ccc(-c3ccncc3)cc21 CHEMBL340921 pKi 63.1 nM
COc1cccc(CNC(=O)c2ccc(-c3ccncc3)cc2)c1 CHEMBL2006299 pKi 63.1 nM
Clc1cc(-c2c[nH]c3ncccc23)ncn1 CHEMBL1972988 pKi 63.1 nM
CS(=O)(=O)NC1CCC(Nc2cc(Cl)nc(-c3c[nH]c4ncccc34)n2)CC1 CHEMBL2005216 pKi 63.1 nM
O=C(NC(CO)c1ccccc1)N1CC=C(c2c[nH]c3ncccc23)CC1 CHEMBL1964937 pKi 63.1 nM
O=C1Nc2ccccc2Nc2cc(-c3ccncc3Cl)ccc21 CHEMBL1987745 pKi 63.1 nM
O=c1nc(-c2ccc3[nH]ncc3c2)cc(-c2ccccc2)[nH]1 CHEMBL526133 pKi 63.1 nM
CCCOc1cccc(C(C)NC(=O)c2ccc(-c3ccncc3)cc2)c1 CHEMBL2007296 pKi 63.1 nM
O=C(c1cc(Cc2n[nH]c(=O)c3c2CCCC3)ccc1F)N1CCN(c2ncccn2)CC1 CHEMBL1986530 pKi 63.1 nM
CCc1ccc2c(NC(=O)Nc3cccc(C(F)(F)F)n3)ccnc2c1 CHEMBL1986756 pKi 63.1 nM
O=C1NCCc2[nH]c(-c3ccnc(-c4cnc5ccccc5c4)c3)cc21 CHEMBL226403 pKi 63.1 nM
O=C1NC(NC23CC4CC(CC(C4)C2)C3)=N/C1=C\c1ccc2c(c1)CCO2 CHEMBL5394613 IC50 66.0 nM
Clc1cc(Cl)cc(CNc2ncncc2-c2ccc3c(c2)OCO3)c1 CHEMBL1885748 IC50 68.0 nM
CC(C)(C)CNc1ncnc2ccc(-c3ccc4c(c3)OCO4)cc12 CHEMBL1551169 IC50 70.0 nM
CC(C)n1cnc2c(Nc3cccc(Cl)c3)nc(N[C@H]3CCCC[C@H]3N)nc21 CHEMBL4073318 IC50 70.0 nM
c1cn(-c2ncnc3ccc(-c4ccoc4)cc23)cn1 CHEMBL1356652 Potency 70.8 nM
COc1ccc2[nH]cc(CCNc3ncnc4ccc(-c5ccc6c(c5)OCO6)cc34)c2c1 CHEMBL1592982 Potency 70.8 nM
COc1ccc2c(/C(C#N)=C/c3cccnc3)c[nH]c2n1 CHEMBL3884570 IC50 71.0 nM
O=C1NC(N[C@H]2CCCC[C@@H]2O)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5398602 IC50 71.0 nM
O=C1NC(NCc2nc3ccccc3s2)=N/C1=C\c1ccc2ncsc2c1 CHEMBL5417975 IC50 71.0 nM
Cc1ccc(NC2=N/C(=C\c3ccc4ncsc4c3)C(=O)N2)cc1F CHEMBL5434778 IC50 71.0 nM
Cn1ncc2cccc(NC3=N/C(=C\c4ccc5ncsc5c4)C(=O)N3)c21 CHEMBL5394513 IC50 73.0 nM
c1cc(-c2ccc3c(c2)OCO3)nc(Nc2ccc3c(c2)OCO3)n1 CHEMBL1885536 IC50 75.0 nM
CC(C)n1cnc2c(Nc3cc(N)cc(Cl)c3)nc(N[C@H]3CCNC3)nc21 CHEMBL4102101 IC50 77.0 nM
COC[C@@H](CC(C)C)NC1=N/C(=C\c2ccc3c(c2)OCO3)C(=O)N1C CHEMBL5406864 IC50 77.1 nM
CN1CCC(NC2=N/C(=C\c3ccc4ncsc4c3)C(=O)N2)CC1 CHEMBL5415615 IC50 78.0 nM
c1coc(CNc2ncnc3ccc(-c4ccc5c(c4)OCO5)cc23)c1 CHEMBL1725513 IC50 79.0 nM
COCC(NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1)C1CCCCC1 CHEMBL5418629 IC50 79.0 nM
CC(=O)Nc1c(C(N)=O)sc2ccc(Cl)c(Cl)c12 CHEMBL1973142 pKi 79.43 nM
CN(C)CCCOc1cc(-c2ccncc2)cc2[nH]nc(N)c12 CHEMBL1988662 pKi 79.43 nM
Cc1ccc(F)c(NC(=O)Nc2ccc(-c3cccc4[nH]nc(N)c34)cc2)c1 CHEMBL223360 pKi 79.43 nM
Cc1cc(NC(=O)Cc2ccc(-c3cccc4[nH]nc(N)c34)cc2)ccc1F CHEMBL1984363 pKi 79.43 nM
c1cc2cc(-c3ccc4cn[nH]c4c3)cnc2[nH]1 CHEMBL1976134 pKi 79.43 nM
Cc1ccc(Nc2nccc(Nc3ccccc3C(=O)O)n2)cc1F CHEMBL243518 pKi 79.43 nM
NC(=O)c1sc2c(Br)ccc(Cl)c2c1N CHEMBL1998611 pKi 79.43 nM
O=C(NC(CO)c1cc(Cl)cc(Cl)c1)c1ccc(-c2ccncc2)cc1 CHEMBL2003341 pKi 79.43 nM
CC(C)(C)c1ccc2nc(-c3n[nH]c4ccccc34)[nH]c2c1 CHEMBL1970104 pKi 79.43 nM
Cc1nc(N)sc1-c1ccnc(Nc2ccc(N3CCOCC3)cc2)n1 CHEMBL482967 pKi 79.43 nM
Cc1cccc(Nc2nc(NC3CCCCC3N)cnc2C(N)=O)c1 CHEMBL1974328 pKi 79.43 nM
NC(Cc1c[nH]c2ccccc12)C(=O)Nc1cncc(C=Cc2ccncc2)c1 CHEMBL1983945 pKi 79.43 nM
COc1ccc(CNc2c(Nc3ccc4[nH]ncc4c3)c(=O)c2=O)cc1 CHEMBL1992536 pKi 79.43 nM
CC(C)(C)c1nc2c3ccc(F)cc3c3c(=O)[nH]ccc3c2[nH]1 CHEMBL21156 pKi 79.43 nM
COc1cc(-c2ccc3c(c2)Nc2ccc(C(=O)NCCCN(C)C)cc2NC3=O)ccc1O CHEMBL1996702 pKi 79.43 nM
COc1c(-c2nc3ccccc3[nH]2)c(O)cc2oc(C)cc(=O)c12 CHEMBL1972355 pKi 79.43 nM
CC(C)(O)c1cn(-c2ccc3[nH]ncc3c2)nn1 CHEMBL2001641 pKi 79.43 nM
COc1cccc(C(C)NC(=O)N2CC=C(c3c[nH]c4ncccc34)CC2)c1 CHEMBL1965845 pKi 79.43 nM
NC(=O)c1cccc2[nH]c(-c3ccncc3)nc12 CHEMBL1990482 pKi 79.43 nM
Cc1cccc(NC(=O)Nc2ccc(-c3cccc4[nH]nc(N)c34)cc2)c1 CHEMBL220057 pKi 79.43 nM
c1ccc(Nc2nc(-c3ccc4[nH]ncc4c3)cs2)cc1 CHEMBL1682545 pKi 79.43 nM
CCOC(=O)c1ccc2[nH]c3c(c2c1)CCNC3=O CHEMBL2005528 pKi 79.43 nM
Brc1cnc2[nH]cc(-c3ccccc3)c2c1 CHEMBL1992634 pKi 79.43 nM
CC#Cc1ccc2nccc(NC(=O)Nc3cccc(C(F)(F)F)n3)c2c1 CHEMBL2007375 pKi 79.43 nM
Cc1cc(-c2ncnc3[nH]ccc23)ccc1F CHEMBL1997041 pKi 79.43 nM
N#Cc1cccc(NC(=O)Nc2ccnc3cc(C(F)(F)F)ccc23)n1 CHEMBL1968868 pKi 79.43 nM
CN(C)CC(=O)Nc1n[nH]c2ccc(-c3cn(Cc4ccccc4)nn3)cc12 CHEMBL1965631 pKi 79.43 nM
Cc1ccsc1CN(C)c1ncnc2ccc(-c3ccc(CO)o3)cc12 CHEMBL1476609 IC50 81.0 nM
CO[C@@H]1[C@H](N(C)CCOCCOCCOCCNC(=O)CCC2=[N+]3C(=Cc4c(C)cc(C)n4[B-]3(F)F)C=C2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL4576489 Kd 81.0 nM
FC(F)(F)c1cc(Br)cc(Nc2nccc(-c3ccc4c(c3)OCO4)n2)c1 CHEMBL2392368 IC50 86.0 nM
CC(C)n1cnc2c(Nc3cccc(Cl)c3)nc(N[C@H]3CCCC[C@@H]3N)nc21 CHEMBL4088144 IC50 86.0 nM
CC(C)C[C@H](COCc1ccccc1)NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5428588 IC50 86.0 nM
CCOC(=O)c1ccc(-c2ccc3ncnc(NCc4cccs4)c3c2)o1 CHEMBL1535925 IC50 88.0 nM
CC(C)c1cnn2c(NCc3ccc(-c4ccccn4)cc3)nc(N[C@H]3CC[C@H](N)CC3)nc12 CHEMBL4284209 IC50 89.0 nM
COC(=O)[C@@H](Cc1ccccc1)NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 CHEMBL5416947 IC50 89.0 nM
Fc1cccc(CNc2ncnc3ccc(-c4ccc5c(c4)OCO5)cc23)c1 CHEMBL566722 Potency 89.1 nM
c1cncc(CNc2ncnc3ccc(-c4ccc5c(c4)OCO5)cc23)c1 CHEMBL566701 Potency 89.1 nM
CC(=O)NCCNc1ncnc2ccc(-c3ccc4c(c3)OCO4)cc12 CHEMBL1474402 Potency 89.1 nM
O=c1cnc2cnc(Nc3ccccc3)nc2n1CCc1ccccc1 CHEMBL1437364 Potency 89.1 nM
O=c1[nH]cnc2c1sc1c(Cl)ccc(Cl)c12 CHEMBL583144 Ki 89.6 nM
c1nc(NCC2CCCC2)c2cc(-c3ccc4c(c3)OCO4)ccc2n1 CHEMBL1354134 IC50 90.0 nM
CO[C@@H]1[C@H](NCCOCCOCCOCCNC(=O)CCC2=[N+]3C(=Cc4c(C)cc(C)n4[B-]3(F)F)C=C2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL4465866 Kd 90.0 nM
Cc1cccc(N(C)c2nccc(-c3cnn4ncccc34)n2)c1 CHEMBL4637319 IC50 90.9 nM
COc1ccc(-c2ccnc(NCc3ccc(Cl)c(Cl)c3)n2)cc1 CHEMBL2392360 IC50 92.0 nM
CC(=O)N1CCN([C@H]2CC[C@H](Nc3ncnn4ccc(C5CCOCC5)c34)CC2)CC1 CHEMBL4290222 IC50 99.0 nM