CCS(=O)(=O)N1CC(CC#N)(n2cc(-c3nc(Nc4ccc(C(=O)NCCCN5CCN(c6ccc(C7CCC(=O)NC7=O)cc6)CC5)cc4)nc4[nH]ccc34)cn2)C1 CHEMBL5090416 IC50 0.02 nM
CCS(=O)(=O)N1CC(CC#N)(n2cc(-c3nc(Nc4ccc(C(=O)NCCN5CCN(c6ccc7c(c6)C(=O)N(C6CCC(=O)NC6=O)C7=O)CC5)cc4)nc4[nH]ccc34)cn2)C1 CHEMBL4744617 IC50 0.31 nM
CCS(=O)(=O)N1CC(CC#N)(n2cc(-c3nc(Nc4ccc(C(=O)NCCN5CCN(c6ccc(C7CCC(=O)NC7=O)cc6)CC5)cc4)nc4[nH]ccc34)cn2)C1 CHEMBL5078429 IC50 0.45 nM
O=C1CCC(N2Cc3ccc(S(=O)(=O)F)cc3C2=O)C(=O)N1 CHEMBL5279477 IC50 1.1 nM
CCS(=O)(=O)N1CC(CC#N)(n2cc(-c3nc(Nc4ccc(C(=O)NCCCCNc5cccc(C6CCC(=O)NC6=O)c5)cc4)nc4[nH]ccc34)cn2)C1 CHEMBL5082689 IC50 1.13 nM
CCS(=O)(=O)N1CC(CC#N)(n2cc(-c3nc(Nc4ccc(C(=O)NCCCCNc5cccc6c5C(=O)N(C5CCC(=O)NC5=O)C6=O)cc4)nc4[nH]ccc34)cn2)C1 CHEMBL4742130 IC50 1.55 nM
O=C1CCC(N2Cc3c(CCCCCNC(=O)[C@@H]4NC5(CCCCC5)[C@@]5(C(=O)Nc6cc(Cl)ccc65)[C@H]4c4cccc(Cl)c4F)cccc3C2=O)C(=O)N1 CHEMBL4449512 IC50 2.0 nM
CCS(=O)(=O)N1CC(CC#N)(n2cc(-c3nc(Nc4ccc(C(=O)NCCCCOc5cccc6c5C(=O)N(C5CCC(=O)NC5=O)C6=O)cc4)nc4[nH]ccc34)cn2)C1 CHEMBL5090604 IC50 3.81 nM
O=C1CCC(N2Cc3c(CCCCCNC(=O)c4ccc(NC(=O)[C@@H]5NC6(CCCCC6)[C@@]6(C(=O)Nc7cc(Cl)ccc76)[C@H]5c5cccc(Cl)c5F)cc4)cccc3C2=O)C(=O)N1 CHEMBL4436772 IC50 5.5 nM
Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)Nc1ccc(Cc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)cc1)c1nnc(C)n1-2 CHEMBL5399086 IC50 8.4 nM
Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)NCCCCCCN1CCC(c3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)CC1)c1nnc(C)n1-2 CHEMBL5422157 IC50 8.9 nM
Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)NCCN1CC(N3CCC(c4ccc5c(c4)CN(C4CCC(=O)NC4=O)C5=O)CC3)C1)c1nnc(C)n1-2 CHEMBL5421315 IC50 10.1 nM
Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)NCCCCCN1CCC(c3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)CC1)c1nnc(C)n1-2 CHEMBL5394571 IC50 10.5 nM
O=C1CC[C@H](N2Cc3c(OCc4ccc(CN5CCOCC5)cc4)cccc3C2=O)C(=O)N1 CHEMBL3989927 IC50 12.8 nM
Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)NCCCCN1CCC(c3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)CC1)c1nnc(C)n1-2 CHEMBL5422650 IC50 14.6 nM
CCS(=O)(=O)N1CC(CC#N)(n2cc(-c3nc(Nc4ccc(C(=O)NCCCN5CCC6(CC5)CCN(c5ccc(C7CCC(=O)NC7=O)cc5)CC6)cc4)nc4[nH]ccc34)cn2)C1 CHEMBL5074539 IC50 15.0 nM
Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)NCCN1CCC(c3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)CC1)c1nnc(C)n1-2 CHEMBL5439152 IC50 17.1 nM
Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)NCCNc1ccc(Cc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)cc1)c1nnc(C)n1-2 CHEMBL5420072 IC50 17.7 nM
Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)NCCCN1CCC(c3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)CC1)c1nnc(C)n1-2 CHEMBL5405846 IC50 17.8 nM
Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)NCCCCCCNc1ccc(Cc3ccc4c(c3)C(=O)N(C3CCC(=O)NC3=O)C4)cc1)c1nnc(C)n1-2 CHEMBL5395213 IC50 18.7 nM
CCS(=O)(=O)N1CC(CC#N)(n2cc(-c3nc(Nc4ccc(C(=O)NCCCCOc5cccc(C6CCC(=O)NC6=O)c5)cc4)nc4[nH]ccc34)cn2)C1 CHEMBL5073737 IC50 19.0 nM
CCS(=O)(=O)N1CC(CC#N)(n2cc(-c3nc(Nc4ccc(C(=O)NCCCCOc5ccc(C6CCC(=O)NC6=O)cc5)cc4)nc4[nH]ccc34)cn2)C1 CHEMBL5082136 IC50 19.6 nM
CCS(=O)(=O)N1CC(CC#N)(n2cc(-c3nc(Nc4ccc(C(=O)NC5CCN(c6ccc7c(c6)C(=O)N(C6CCC(=O)NC6=O)C7=O)CC5)cc4)nc4[nH]ccc34)cn2)C1 CHEMBL5092577 IC50 20.2 nM
Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)NCCN1CC3(CCC(c4ccc5c(c4)CN(C4CCC(=O)NC4=O)C5=O)CC3)C1)c1nnc(C)n1-2 CHEMBL5432640 IC50 20.7 nM
Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)NCCCCCNc1ccc(Cc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)cc1)c1nnc(C)n1-2 CHEMBL5398776 IC50 20.9 nM
O=C1CCC(N2Cc3ccc(S(=O)(=O)n4nccn4)cc3C2=O)C(=O)N1 CHEMBL5431754 IC50 21.1 nM
CCS(=O)(=O)N1CC(CC#N)(n2cc(-c3nc(Nc4ccc(C(=O)NCCCN5CC6CC5CN6c5ccc(C6CCC(=O)NC6=O)cc5)cc4)nc4[nH]ccc34)cn2)C1 CHEMBL5077200 IC50 23.9 nM
Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)NCCCCNc1ccc(Cc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)cc1)c1nnc(C)n1-2 CHEMBL5431364 IC50 24.9 nM
Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)NCCCNc1ccc(Cc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)cc1)c1nnc(C)n1-2 CHEMBL5405431 IC50 26.0 nM
Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)NCCN1CCC3(CCC(c4ccc5c(c4)CN(C4CCC(=O)NC4=O)C5=O)CC3)CC1)c1nnc(C)n1-2 CHEMBL5415959 IC50 27.5 nM
Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)Nc1ccc(OCCOCCOCCOCCNc3cccc4c3C(=O)N(C3CCC(=O)NC3=O)C4=O)cc1)c1nnc(C)n1-2 CHEMBL4226052 Kd 28.0 nM
O=C1CCC(N2Cc3ccc(S(=O)(=O)n4ccnc4)cc3C2=O)C(=O)N1 CHEMBL5439475 IC50 41.9 nM
O=C1CCC(N2Cc3ccc(S(=O)(=O)n4cc(C(F)(F)F)cn4)cc3C2=O)C(=O)N1 CHEMBL5430120 IC50 43.6 nM
O=C1CCC(N2Cc3ccc(S(=O)(=O)n4ccc(C(F)(F)F)n4)cc3C2=O)C(=O)N1 CHEMBL5419977 IC50 50.4 nM
O=C1CCC(N2Cc3ccc(S(=O)(=O)n4cnc(C(F)(F)F)c4)cc3C2=O)C(=O)N1 CHEMBL5431074 IC50 54.9 nM
O=C1CCC(N2Cc3ccc(S(=O)(=O)F)cc3C2)C(=O)N1 CHEMBL5431003 IC50 71.0 nM
O=C1CCC(N2Cc3ccc(S(=O)(=O)n4cncn4)cc3C2=O)C(=O)N1 CHEMBL5420894 IC50 77.9 nM
C=CC(=O)N1CCN(c2nc(NCCCN3CCN(CCCNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)nc3c(F)c(-c4cc(O)cc5ccccc45)c(Cl)cc23)CC1 CHEMBL5275511 EC50 79.0 nM
Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O CHEMBL43452 IC50 83.0 nM
C[C@H]1CN(C(=O)CNc2cccc3c2C(=O)N(C2CCC(=O)NC2=O)C3=O)CCN1c1ccc(Nc2cc(-c3ccnc(N4CCn5c(cc6c5CC(C)(C)C6)C4=O)c3CO)cn(C)c2=O)nc1 CHEMBL5408743 IC50 107.0 nM
O=C1CCC(N2Cc3c(NC(=O)CNc4ccnc(N5CCN(c6cccc(C(F)(F)F)c6)CC5)n4)cccc3C2=O)C(=O)N1 CHEMBL4648907 Ki 130.0 nM
CN(CCCC#Cc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O)C(=O)CCN(C(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)c1cc2cc(C(F)(F)P(=O)(O)O)ccc2s1)C(C)(C)C)c1ccc(-c2nccs2)cc1 CHEMBL5399100 Ki 170.0 nM
Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCCCCOCCOCCCCCOCC(=O)NCCNc2cccc3c2C(=O)N(C2CCC(=O)NC2=O)C3=O)C(C)(C)C)cc1 CHEMBL4760789 DC50 200.0 nM
Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)N1CCC(c3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)CC1)c1nnc(C)n1-2 CHEMBL5394825 IC50 215.9 nM
O=C1CCC(N2Cc3c(O)cccc3C2=O)C(=O)N1 CHEMBL2324726 IC50 234.0 nM
O=C1CCC(N2Cc3ccc(OS(=O)(=O)F)cc3C2=O)C(=O)N1 CHEMBL5289875 IC50 255.0 nM
O=C1CCC(N2Cc3ccc(S(=O)(=O)n4cnc(F)c4)cc3C2=O)C(=O)N1 CHEMBL5429393 IC50 324.0 nM
O=C1CCC(N2Cc3cccc(O)c3C2=O)C(=O)N1 CHEMBL2324704 IC50 337.0 nM
O=C1CCC(N2C(=O)c3ccc(O)cc3C2=O)C(=O)N1 CHEMBL182442 IC50 376.0 nM
Nc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O CHEMBL40206 IC50 382.0 nM
Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O CHEMBL848 IC50 390.0 nM
CCCCNc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=O CHEMBL5415637 Ki 430.0 nM
O=C1CCC(N2Cc3c(NC(=O)CNc4ccnc(N5CCC[C@@H]5CO)n4)cccc3C2=O)C(=O)N1 CHEMBL4635421 Ki 440.0 nM
Cc1cn(S(=O)(=O)c2ccc3c(c2)C(=O)N(C2CCC(=O)NC2=O)C3)cn1 CHEMBL5399248 IC50 454.0 nM
CC(C)c1ccn2ncnc(N[C@H]3CC[C@@H](N4CCN(C(=O)CCC(=O)N5CCC(CCN6CCN(c7ccc8c(c7)C(=O)N(C7CCC(=O)NC7=O)C8=O)CC6)CC5)CC4)CC3)c12 CHEMBL4749646 IC50 460.0 nM
CC(C)Nc1cc(-n2ccc3cc(C#N)cnc32)ccc1C(=O)N[C@H]1CC[C@H](C(=O)NCCOCCNC(=O)COc2cccc3c2C(=O)N(C2CCC(=O)NC2=O)C3=O)CC1 CHEMBL5272173 Kd 490.0 nM
CC(C)Nc1cc(-n2ccc3cc(C#N)cnc32)ncc1C(=O)N[C@H]1CC[C@H](C(=O)NCCOCCNC(=O)COc2cccc3c2C(=O)N(C2CCC(=O)NC2=O)C3=O)CC1 CHEMBL5405716 Kd 490.0 nM
O=C1CCC(CSc2cccc([N+](=O)[O-])c2)C(=O)N1 CHEMBL5409302 Ki 500.0 nM
O=C1CCC(N2C(=O)c3ccc(N4CCC4)cc3C2=O)C(=O)N1 CHEMBL5438540 Ki 500.0 nM
O=C1CCC(N2Cc3ccccc3C2=O)C(=O)N1 CHEMBL304572 IC50 550.0 nM
Nc1ccc2c(c1)C(=O)N(C1CCC(=O)NC1=O)C2=O CHEMBL43855 IC50 560.0 nM
O=C1CCC(N2C(=O)c3cccc(O)c3C2=O)C(=O)N1 CHEMBL2324714 IC50 630.0 nM
Nc1ccc2c(c1)C(=O)N(C1CCC(=O)NC1=O)C2 CHEMBL297116 IC50 658.0 nM
CCC[C@H](NC(=O)[C@@H]1[C@H]2CCC[C@H]2CN1C(=O)[C@@H](NC(=O)[C@@H](NC(=O)c1cnc(C(=O)NCCOCCOCCOc2cc3c4c(cccc4c2)C(=O)N(C2CCC(=O)NC2=O)C3=O)cn1)C1CCCCC1)C(C)(C)C)C(=O)C(=O)NC1CC1 CHEMBL5184599 EC50 703.0 nM
Nc1ccc(C(=O)NC2CCC(=O)NC2=O)c2ncccc12 CHEMBL4648134 Ki 800.0 nM
O=C1CCC(N2Cc3cccc(OCc4ccc(CN5CCOCC5)cc4)c3C2)C(=O)N1 CHEMBL5400126 IC50 808.0 nM
CN(c1ccccc1)c1nccc(NCC(=O)Nc2cccc3c2CN(C2CCC(=O)NC2=O)C3=O)n1 CHEMBL4645406 Ki 970.0 nM