CC(=O)N1CCc2c(c(-c3cccc4cc(-c5ccc(C(=O)NC6CCN(c7ccc8c(c7)CN(C7CCC(=O)NC7=O)C8=O)CC6)nc5)ncc34)nn2C2CCOCC2)C1 CHEMBL5413450 EC50 0.05 nM
CC(=O)N1CCc2c(c(-c3cccc4cc(-c5ccc(C(=O)NCCCCCCCCNc6cccc7c6C(=O)N(C6CCC(=O)NC6=O)C7=O)nc5)ncc34)nn2C2CCOCC2)C1 CHEMBL5406029 EC50 0.2 nM
CC(=O)N1CCc2c(c(-c3cccc4cc(-c5ccc(C(=O)NCCCCc6cccc7c6CN(C6CCC(=O)NC6=O)C7=O)nc5)ncc34)nn2C2CCOCC2)C1 CHEMBL5426454 EC50 0.2 nM
CC(=O)N1CCc2c(c(-c3cccc4cc(-c5ccc(C(=O)NCCCCCc6cccc7c6CN(C6CCC(=O)NC6=O)C7=O)nc5)ncc34)nn2C2CCOCC2)C1 CHEMBL5409708 EC50 0.2 nM
CC(=O)N1CCc2c(c(-c3cccc4cc(-c5ccc(C(=O)NCCCNc6cccc7c6CN(C6CCC(=O)NC6=O)C7=O)nc5)ncc34)nn2C2CCOCC2)C1 CHEMBL5437022 EC50 0.2 nM
CC(=O)N1CCc2c(c(-c3cccc4cc(-c5ccc(C(=O)N6CCN(c7cccc8c7C(=O)N(C7CCC(=O)NC7=O)C8=O)CC6)nc5)ncc34)nn2C2CCOCC2)C1 CHEMBL5405858 EC50 0.2 nM
CNC(=O)c1ccc(-c2cc3cccc(-c4nn(C5CCOCC5)c5c4CN(C(C)=O)CC5)c3cn2)cn1 CHEMBL4208820 Kd 0.23 nM
CC(=O)N1CCc2c(c(-c3cccc4cc(-c5ccc(C(=O)N6CC7(CC(Nc8cccc9c8C(=O)N(C8CCC(=O)NC8=O)C9=O)C7)C6)nc5)ncc34)nn2C2CCOCC2)C1 CHEMBL5402691 EC50 0.3 nM
COc1ccc2c(c1)N(CCCNC(=O)c1cccc3c1N[C@H](C)C(=O)N3)CCC2 CHEMBL3752296 Kd 0.39 nM
CC(=O)N1CCc2c(c(-c3cccc4cc(-c5ccc(C(=O)NCCCCCCNc6cccc7c6C(=O)N(C6CCC(=O)NC6=O)C7=O)nc5)ncc34)nn2C2CCOCC2)C1 CHEMBL5439670 EC50 0.6 nM
CC(=O)N1CCc2c(c(-c3cccc4cc(-c5ccc(C(=O)NCCNc6cccc7c6CN(C6CCC(=O)NC6=O)C7=O)nc5)ncc34)nn2C2CCOCC2)C1 CHEMBL5395475 EC50 0.6 nM
Cc1nc(SCc2nc3ccccc3[nH]2)c2oc3ccccc3c2n1 CHEMBL1574971 Potency 0.8 nM
CNC(=O)N1CCc2c(c(-c3cccc4cc(-c5cnn(C)c5)c(C(F)F)cc34)nn2C2CCOCC2)C1 CHEMBL4217213 IC50 0.9 nM
CNC(=O)N1CCc2c(c(N3CCCc4cc(-c5cnn(C)c5)c(C(F)F)cc43)nn2C2CCOCC2)C1 CHEMBL4097025 IC50 0.94 nM
Cn1cc(-c2cc3c(cc2C(F)F)N(c2nn(C4CCOCC4)c4c2CN(C(N)=O)CC4)CCC3)cn1 CHEMBL4069831 IC50 1.0 nM
CC(=O)N1CCC(n2nc(N3CCCc4cc(-c5cnn(C)c5)c(C(F)F)cc43)c3c2CCN(C(C)=O)C3)CC1 CHEMBL4088793 IC50 1.0 nM
COc1ccc(C2(C(=O)N3C[C@H](F)C[C@@H]3C(=O)Nc3ccc4[nH]ncc4n3)CCC(F)(F)CC2)cc1 CHEMBL5438086 IC50 1.0 nM
CC(=O)N1CCc2c(c(-c3cccc4cc(-c5ccc(C(=O)NCCCCCNc6cccc7c6C(=O)N(C6CCC(=O)NC6=O)C7=O)nc5)ncc34)nn2C2CCOCC2)C1 CHEMBL5438596 EC50 1.0 nM
CC(=O)N1CCc2c(c(-c3cccc4cc(-c5ccc(C(=O)NC6CCN(c7ccc8c(c7)C(=O)N(C7CCC(=O)NC7=O)C8=O)CC6)nc5)ncc34)nn2C2CCOCC2)C1 CHEMBL5397398 EC50 1.0 nM
CC(=O)N1CCc2c(c(N3CCCc4cc(-c5cnn(C)c5)c(C(F)F)cc43)nn2C2CCOCC2)C1 CHEMBL4076748 IC50 1.1 nM
CC(=O)N1CCc2c(c(-c3cccc4cc(-c5ccc(C(=O)NCCNc6ccc7c(c6)CN(C6CCC(=O)NC6=O)C7=O)nc5)ncc34)nn2C2CCOCC2)C1 CHEMBL5419387 EC50 1.1 nM
CC(=O)N1CCc2c(c(N3CCCc4cc(-c5cnn(C)c5)c(C(F)F)cc43)nn2C2CCS(=O)(=O)CC2)C1 CHEMBL4061161 IC50 1.2 nM
CC(=O)N1CCc2c(c(N3CCCc4cc(-c5cnn(C)c5)c(C(F)F)cc43)nn2C2CCN(S(C)(=O)=O)CC2)C1 CHEMBL4060566 IC50 1.2 nM
CC(=O)N1CCc2c(c(-c3cccc4cc(-c5cnn(C)c5)ncc34)nn2C2CCOCC2)C1 CHEMBL4203082 IC50 1.2 nM
CC(=O)N1CCc2c(c(-c3cccc4cc(-c5ccc(C(=O)NCCCNc6cccc7c6C(=O)N(C6CCC(=O)NC6=O)C7=O)nc5)ncc34)nn2C2CCOCC2)C1 CHEMBL5412027 EC50 1.2 nM
CC(=O)N1CCc2c(c(-c3cccc4cc(-c5ccc(C(=O)NCCCCNc6cccc7c6C(=O)N(C6CCC(=O)NC6=O)C7=O)nc5)ncc34)nn2C2CCOCC2)C1 CHEMBL5405240 EC50 1.3 nM
CC(=O)N1CCc2c(c(N3CCCc4cc(-c5cnn(C)c5)c(C(F)F)cc43)nn2[C@H]2CCOC2)C1 CHEMBL4061600 IC50 1.4 nM
CC(=O)c1cc(C(=O)Nc2cc(C(C)O)cc(-c3cnn(C4CC4)c3)c2F)c2cc(N)ccn12 CHEMBL5204688 IC50 1.48 nM
CC(=O)N1CCc2c(c(N3CCCc4cc(-c5cnn(C)c5)c(C(F)F)cc43)nn2C2CCNCC2)C1 CHEMBL4080905 IC50 1.5 nM
CC(=O)N1CCc2c(c(N3CCCc4cc(-c5cnn(C)c5)c(C(F)(F)F)cc43)nn2[C@H]2CCOC2)C1 CHEMBL4083416 IC50 1.5 nM
CC(=O)N1CCc2c(c(-c3cccc4cc(-c5ccc(C(=O)NCCNc6cccc7c6C(=O)N(C6CCC(=O)NC6=O)C7=O)nc5)ncc34)nn2C2CCOCC2)C1 CHEMBL5397498 EC50 1.7 nM
CC(=O)N1CCc2c(c(-c3cccc4cc(-c5ccc(C(=O)N6CCC7(CC6)CC(Nc6cccc8c6C(=O)N(C6CCC(=O)NC6=O)C8=O)C7)nc5)ncc34)nn2C2CCOCC2)C1 CHEMBL5429111 EC50 1.7 nM
COC1CCC(n2c([C@H]3CCCC(=O)N3c3ccc(F)c(F)c3)nc3cc(-c4c(C)noc4C)ccc32)CC1 CHEMBL5409153 Kd 1.7 nM
COC[C@@H](C)n1c(C2CCOCC2)nc2cnc3cc(-c4c(C)noc4C)c(OC)cc3c21 CHEMBL4878439 Activity 1.73 nM
CC(=O)N1CCc2c(c(-c3cccc4cc(-c5ccc(C(=O)N6CCC(Nc7cccc8c7C(=O)N(C7CCC(=O)NC7=O)C8=O)CC6)nc5)ncc34)nn2C2CCOCC2)C1 CHEMBL5433043 EC50 1.8 nM
CC(=O)c1cc(C(=O)Nc2cc(CO)cc(-c3cnn(C)c3)c2F)c2cc(N)ccn12 CHEMBL5191045 IC50 1.89 nM
CC(=O)N1CCc2c(c(N3CCCc4cc(-c5cnn(C)c5)c(C(F)F)cc43)nn2C2CCN(C)CC2)C1 CHEMBL4098938 IC50 2.0 nM
CO[C@H]1CC[C@H](n2c([C@@H]3CCCC(=O)N3c3ccc(F)c(F)c3)nc3cc(-c4c(C)noc4C)ccc32)CC1 CHEMBL4785363 IC50 2.05 nM
CNc1ccn2c(C(C)=O)cc(C(=O)Nc3cc(CO)cc(-c4cnn(C)c4)c3F)c2c1 CHEMBL5179328 IC50 2.1 nM
CNC(=O)c1c[nH]c2c(C(C)C)nc(N3CCCc4cc(-c5cnn(C)c5)c(C(F)F)cc43)cc12 CHEMBL4061254 IC50 2.2 nM
CC(=O)N1CCc2c(c(-c3cccc4cc(-c5cn(C)nc5C#N)ncc34)nn2C2CCOCC2)C1 CHEMBL4204065 IC50 2.4 nM
CC1=NN(c2ccc(C(=O)O)cc2)C(=O)/C1=C/c1ccc(-c2cc(C)c(C)cc2[N+](=O)[O-])o1 CHEMBL3734823 IC50 2.6 nM
CNC(=O)Nc1ccc2c(c1)CC[C@@]21OC(=O)N(CC(=O)N(Cc2ccc(F)cc2)[C@@H](C)C(F)(F)F)C1=O CHEMBL4282264 IC50 2.6 nM
CC(=O)N1CCc2c(c(-c3cccc4cc(-c5cnn(C)c5C(F)F)ncc34)nn2C2CCOCC2)C1 CHEMBL4207965 IC50 2.8 nM
C[C@H](CN[C@@H](C(=O)Nc1ccc(-c2cnn(C)c2)cn1)c1ccccc1)c1ccc(C#N)cc1 CHEMBL4641354 IC50 2.9 nM
CC(=O)c1cc(C(=O)Nc2cc(CO)cc(-c3cnn(C4CC4)c3)c2F)c2cc(N)ccn12 CHEMBL5179809 IC50 2.96 nM
CCOc1ccc(C(C)=O)cc1NC(=O)c1cc(-c2cscn2)cc(-c2nn[nH]n2)c1 CHEMBL4210443 Kd 3.0 nM
CC(=O)N1CCc2c(c(N3CCCc4cc(-c5cnn(C)c5)c(C(F)F)cc43)nn2C2CCCCC2)C1 CHEMBL4091202 IC50 3.1 nM
Cn1cc(-c2ccc3c(C(=O)[C@H](NCCc4ccc(C#N)cc4)c4ccccc4)c[nH]c3c2)cn1 CHEMBL4633516 IC50 3.2 nM
CC(=O)N1CCc2c(c(-c3cccc4cc(-c5cn(C)nc5C(F)F)ncc34)nn2C2CCOCC2)C1 CHEMBL4209361 IC50 3.3 nM
CC(=O)N1CCc2c(c(-c3cccc4cc(-c5cnn(C)c5C#N)ncc34)nn2C2CCOCC2)C1 CHEMBL4204490 IC50 3.3 nM
CC(=O)N1CCc2c(c(-c3cccc4cc(-c5ccc(C(=O)NCCCc6cccc7c6CN(C6CCC(=O)NC6=O)C7=O)nc5)ncc34)nn2C2CCOCC2)C1 CHEMBL5418675 EC50 3.3 nM
C[C@@H]1CC(=O)Nc2cccc(N3CCCc4cc(-c5cnn(C)c5)c(C(F)F)cc43)c2N1 CHEMBL4068116 IC50 3.4 nM
Cn1cc(-c2cc3c(cc2C(F)F)N(c2cc(N4CCOCC4)c4c(c2)n(C)c(=O)n4C)CCC3)cn1 CHEMBL4095153 IC50 3.6 nM
CC(=O)N1CCc2c(c(-c3cccc4cc(-c5ccc(C(=O)N6CCC(C7CN(c8cccc9c8C(=O)N(C8CCC(=O)NC8=O)C9=O)C7)CC6)nc5)ncc34)nn2C2CCOCC2)C1 CHEMBL5419069 EC50 3.7 nM
COc1ccn2c(C(C)=O)cc(C(=O)Nc3cc(C(C)O)cc(-c4cnn(C5CC5)c4)c3F)c2c1 CHEMBL5179520 IC50 4.21 nM
CC(=O)N1CCc2c(c(N3CCCc4cc(-c5cnn(C)c5)c(Cl)cc43)nn2[C@H]2CCOC2)C1 CHEMBL4099857 IC50 4.3 nM
CC(=O)N1CCc2c(c(N3CCCc4cc(-c5cnn(C)c5)c(C)cc43)nn2[C@H]2CCOC2)C1 CHEMBL4062259 IC50 4.4 nM
COc1cc2c(cc1-c1cnn(C)c1)CCCN2c1nn([C@H]2CCOC2)c2c1CN(C(C)=O)CC2 CHEMBL4072979 IC50 4.7 nM
CC(=O)N1CCc2c(c(-c3cccc4cc(-c5ccc(C(=O)N6CC7(CCC(Nc8cccc9c8C(=O)N(C8CCC(=O)NC8=O)C9=O)CC7)C6)nc5)ncc34)nn2C2CCOCC2)C1 CHEMBL5405265 EC50 4.8 nM
CNC(=O)c1c[nH]c2cnc(N3CCCc4cc(-c5cnn(C)c5)c(C(F)F)cc43)cc12 CHEMBL4073812 IC50 5.0 nM
Cn1cc(-c2ccc(NC(=O)[C@H](NCCc3ccc(C#N)cc3)c3ccccc3)nc2)cn1 CHEMBL4636118 IC50 6.7 nM
CNC(=O)Nc1ccc2c(c1)CC[C@@]21OC(=O)N(CC(=O)N2Cc3cc(F)c(F)cc3CC[C@H]2C2CC2)C1=O CHEMBL5082755 IC50 7.0 nM
Cc1cc(C)n(-c2nc(Nc3ccccc3)nc(-n3nc(C)cc3C)n2)n1 CHEMBL1449105 Potency 7.1 nM
CNC(=O)Nc1ccc2c(c1)CC[C@@]21OC(=O)N(CC(=O)N2Cc3cc(F)ccc3OC[C@H]2C2CC2)C1=O CHEMBL5090239 IC50 7.1 nM
CNC(=O)Nc1ccc2c(c1)CC[C@@]21OC(=O)N(CC(=O)N2Cc3ccc(F)cc3CC[C@H]2C2CC2)C1=O CHEMBL4475351 IC50 8.1 nM
CNC(=O)Nc1cc2c(cc1F)[C@@]1(CC2)OC(=O)N(CC(=O)N2Cc3ccc(F)cc3CC[C@H]2C2CC2)C1=O CHEMBL5083020 IC50 8.2 nM
O=C(Cc1ccccc1)Nc1nc2ccc(Cl)cc2c2nc(-c3ccco3)nn12 CHEMBL88147 Potency 8.9 nM
CNC(=O)c1c[nH]c2ccc(N3CCCc4cc(-c5cnn(C)c5)c(C(F)F)cc43)cc12 CHEMBL4065346 IC50 9.5 nM
COc1ccn2c(C(C)=O)cc(C(=O)Nc3cc(C(=O)O)cc(-c4cnn(C)c4)c3F)c2c1 CHEMBL5205974 IC50 9.8 nM
CNC(=O)Nc1ccc2c(c1)CC[C@@]21OC(=O)N(CC(=O)N2Cc3sccc3OC[C@H]2C2CC2)C1=O CHEMBL5094423 IC50 12.0 nM
CC(=O)N1CCc2c(c(-c3cccc4cc(-c5ccc(C(=O)NCCCCCCCNc6cccc7c6C(=O)N(C6CCC(=O)NC6=O)C7=O)nc5)ncc34)nn2C2CCOCC2)C1 CHEMBL5434991 EC50 12.0 nM
COc1ccn2c(C(C)=O)cc(C(=O)Nc3cc(CO)cc(-c4cnn(C)c4)c3F)c2c1 CHEMBL5198394 IC50 12.04 nM
CNC(=O)N1CCOc2ccc(N3CCCc4cc(-c5cnn(C)c5)c(C(F)F)cc43)cc2C1 CHEMBL4076254 IC50 13.0 nM
CC(=O)N1CCc2c(c(-c3ccc(C)c4ccncc34)nn2C2CCOCC2)C1 CHEMBL4215166 IC50 13.0 nM
COc1ccn2c(C(C)=O)cc(C(=O)Nc3cc(C=O)cc(-c4cnn(C)c4)c3F)c2c1 CHEMBL5195756 IC50 13.01 nM
C[C@@H]1CC(=O)Nc2cccc(-c3ccc4c(c3)c(-c3cnn(C)c3)nn4C)c2N1 CHEMBL3814752 IC50 13.95 nM
CC(=O)c1cc(C(=O)Nc2cc(CO)cc(-c3cnn(C)c3)c2F)c2cc(C)ccn12 CHEMBL5191527 IC50 13.95 nM
CNC(=O)Nc1ccc2c(c1)CCC[C@@]21OC(=O)N(CC(=O)N2Cc3ccc(F)cc3CC[C@H]2C2CC2)C1=O CHEMBL5077158 IC50 14.0 nM
CC(=O)N1CCc2c(c(N3CCCc4cc(-c5cnn(C)c5)ccc43)nn2[C@H]2CCOC2)C1 CHEMBL4077449 IC50 16.0 nM
CCOc1ccc(C(C)=O)cc1NC(=O)c1cc(NC(C)=O)cc(NC(=O)c2ccco2)c1 CHEMBL4205572 IC50 19.0 nM
Cc1cc(-c2ccc3nc(C4CCOCC4)n(CCOC(F)(F)F)c3c2)cn(C)c1=O CHEMBL5274024 Kd 19.0 nM
CNC(=O)N1CCCc2ccc(NC(=O)c3ccc(-c4cc[nH]n4)cc3)cc21 CHEMBL4795699 IC50 19.5 nM
CC(=O)N1CCc2c(c(Nc3ccc(-c4cnn(C)c4)cc3F)nn2[C@@H]2CCOC2)C1 CHEMBL3968533 IC50 20.0 nM
Cn1cc(-c2cc3c(cc2C(F)F)N(c2ccc4c(c2)n(C)c(=O)n4C)CCC3)cn1 CHEMBL4072630 IC50 20.0 nM
CC(=O)N1CCc2c(c(Nc3ccc(-c4cnn(C)c4)cc3F)nn2[C@H]2CCOC2)C1 CHEMBL3897393 IC50 20.0 nM
COc1ccc(CCc2nc3cc(-c4c(C)noc4C)ccc3n2C[C@H](C)N2CCOCC2)cc1Cl CHEMBL3622373 Kd 21.0 nM
COc1ccc(CCc2cc3cc(-c4c(C)noc4C)ccc3n2CCN2CCOCC2)cc1F CHEMBL3752200 Kd 21.0 nM
Cc1noc(C)c1-c1ccc2c(c1)nc(CCc1ccccc1)n2C[C@H](C)N1CCOCC1 CHEMBL3775371 Kd 21.0 nM
CC(=O)c1cc(C(=O)Nc2cc(CO)cc(-c3cnn(C4CC4)c3)c2F)c2cc(OC(=O)N(C)C)ccn12 CHEMBL5192803 IC50 21.32 nM
CCc1ccn2c(C(C)=O)cc(C(=O)Nc3cc(CO)cc(-c4cnn(C)c4)c3F)c2c1 CHEMBL5195875 IC50 21.77 nM
COc1ccc(CCc2nc3cc(-c4c(C)noc4C)ccc3n2CCN2CCOCC2)cc1F CHEMBL3753048 Kd 22.0 nM
CNC(=O)Nc1ccc2c(c1)OCC[C@@]21OC(=O)N(CC(=O)N2Cc3ccc(F)cc3CC[C@H]2C2CC2)C1=O CHEMBL5081689 IC50 22.0 nM
COc1cncc2c(-c3nn(C4CCOCC4)c4c3CN(C(C)=O)CC4)cccc12 CHEMBL4209359 IC50 23.0 nM
CCc1cc(-c2nn(C3CCOCC3)c3c2CN(C(C)=O)CC3)c2cnccc2c1 CHEMBL4214979 IC50 24.0 nM
CC(=O)c1cc(C(=O)Nc2cc(CO)cc(-c3cnn(C4CC4)c3)c2F)c2cc(O)ccn12 CHEMBL5198835 IC50 24.84 nM
CC(=O)c1cc(C(=O)Nc2cc(C(C)O)cc(-c3cnn(C4CC4)c3)c2F)c2cc(OC(=O)N(C)C)ccn12 CHEMBL5208356 IC50 26.22 nM
CC(=O)c1cc(C(=O)Nc2cc(CO)cc(-c3cnn(C)c3)c2F)c2cc(O)ccn12 CHEMBL5192405 IC50 26.37 nM
COc1ccc(-c2nn(C3CCOCC3)c3c2CN(C(C)=O)CC3)c2cnccc12 CHEMBL4217552 IC50 27.0 nM
COc1ccc(CCc2nc3cc(-c4c(C)noc4C)ccc3n2CCN2CCOCC2)cc1Cl CHEMBL4754613 Kd 28.0 nM
CNC(=O)Nc1ccc2c(c1)CC[C@@]21OC(=O)N(CC(=O)N2Cc3ccccc3CC[C@H]2C)C1=O CHEMBL4524352 IC50 28.0 nM
CNC(=O)Nc1ccc2c(c1)CC[C@@]21OC(=O)N(CC(=O)N2Cc3ccncc3CC[C@H]2C2CC2)C1=O CHEMBL5078021 IC50 28.0 nM
COc1ccc([C@@H]2CNC(=O)C2)cc1OC1CCCC1 CHEMBL430893 Potency 28.2 nM
CC(=O)N1CCc2c(c(-c3cccc4ccncc34)nn2C2CCOCC2)C1 CHEMBL4218138 IC50 30.0 nM
CNC(=O)Nc1ccc2c(c1)CC[C@@]21OC(=O)N(CC(=O)N2Cc3ncccc3CC[C@H]2C2CC2)C1=O CHEMBL5078353 IC50 30.0 nM
CCNC(=O)N1CCc2c(c(N3CCCc4cc(-c5cnn(C)c5)c(C(F)F)cc43)nn2C2CCOCC2)C1 CHEMBL4080528 IC50 31.0 nM
CC(=O)N1CCc2c(c(N3CCc4cc(-c5cnn(C)c5)ccc43)nn2[C@H]2CCOC2)C1 CHEMBL4095660 IC50 31.0 nM
CC(=O)N1CCc2c(c(-c3cccc4[nH]ccc34)nn2CC2CC2)C1 CHEMBL4207043 IC50 31.0 nM
CCc1ccc(-c2nn(C3CCOCC3)c3c2CN(C(C)=O)CC3)c2cnccc12 CHEMBL4209747 IC50 31.0 nM
C[C@@H]1CC(=O)Nc2cccc(-c3ccc4c(c3)c(C3CC3)nn4C)c2N1 CHEMBL3814550 IC50 33.0 nM
CNC(=O)c1ccc2nccc(N3CCCc4cc(-c5cnn(C)c5)c(C(F)F)cc43)c2c1 CHEMBL4059634 IC50 34.0 nM
COc1ccc2c(c1)c(C(=O)Nc1cc(C(=O)O)cc(-c3cnn(C)c3)c1F)cn2C(C)=O CHEMBL4171749 IC50 37.0 nM
CNC(=O)N1CCCc2ccc(NC(=O)c3ccc(-c4cnn(C)c4)cc3)cc21 CHEMBL4790542 IC50 37.4 nM
CN1C(=O)CCc2ccc(N3CCCc4cc(-c5cnn(C)c5)c(C(F)F)cc43)cc21 CHEMBL4095016 IC50 38.0 nM
CCc1cncc2c(-c3nn(C4CCOCC4)c4c3CN(C(C)=O)CC4)cccc12 CHEMBL4213692 IC50 38.0 nM
C[C@@H]1CC(=O)Nc2cccc(C(=O)Nc3cccc(-c4cnco4)c3)c2N1 CHEMBL3814896 IC50 39.0 nM
COc1ccc(C2=Nn3c(nnc3-c3ccccc3OC)SC2)cc1OC CHEMBL251785 Potency 39.8 nM
CCOc1ccc(C(C)=O)cc1-c1cc(NC(=O)c2ccco2)cc(-c2c(C)noc2C)c1 CHEMBL4207490 IC50 40.0 nM
COc1ccc(C2(C(=O)N3CS(=O)(=O)C[C@@H]3C(=O)Nc3cccc4[nH]ncc34)CCCC2)cc1 CHEMBL5193672 IC50 40.0 nM
CC(=O)N1CCc2c(c(-c3cccc4cc(-c5ccc(C(=O)N6CCC(C7CCN(c8cccc9c8C(=O)N(C8CCC(=O)NC8=O)C9=O)CC7)CC6)nc5)ncc34)nn2C2CCOCC2)C1 CHEMBL5431340 EC50 40.0 nM
CNC(=O)N1CCCc2ccc(NC(=O)c3ccc(-c4ccn(C)n4)cc3)cc21 CHEMBL4741233 IC50 40.2 nM
CNC(=O)Nc1ccc2c(c1)CC[C@@]21OC(=O)N(CC(=O)N2Cc3cnccc3CC[C@H]2C2CC2)C1=O CHEMBL5084035 IC50 41.0 nM
CC(=O)c1cc(C(=O)Nc2cc(CO)cc(-c3cnn(C)c3)c2F)c2cc(OC(=O)C(C)(C)C)ccn12 CHEMBL5200678 IC50 41.95 nM
CC(=O)N1CCc2c(c(-c3cccc4c(Cl)cncc34)nn2C2CCOCC2)C1 CHEMBL4208936 IC50 42.0 nM
CC(=O)N1CCc2c(c(-c3c[nH]c4ccccc34)nn2C2CCOCC2)C1 CHEMBL4207080 IC50 43.0 nM
CNC(=O)Nc1ccc2c(c1)CC[C@@]21OC(=O)N(CC(=O)N2Cc3cccnc3CC[C@H]2C2CC2)C1=O CHEMBL5085891 IC50 44.0 nM
CNC(=O)N1CCCc2ccc(NC(=O)c3cccc(-c4ccn(C)n4)c3)cc21 CHEMBL4793642 IC50 45.7 nM
CC(=O)N1CCc2c(cc(N3CCCc4cc(-c5cnn(C)c5)c(C(F)F)cc43)c(=O)n2C)C1 CHEMBL4097991 IC50 47.0 nM
COc1cc2c(cc1-c1c(C)noc1C)[nH]c1nc(C)nc(Nc3cc(C4CC4)nn3C)c12 CHEMBL4173488 Kd 47.0 nM
CNC(=O)N1CCCc2ccc(NC(=O)c3ccc(-c4cn[nH]c4)cc3)cc21 CHEMBL4791519 IC50 47.7 nM
COc1ccc(CCc2nc3cc(-c4c(C)noc4C)ccc3n2CCN2CCOCC2)cc1 CHEMBL4084580 Kd 50.0 nM
CNC(=O)Nc1ccc2c(c1)COC[C@@]21OC(=O)N(CC(=O)N2Cc3cc(F)ccc3OC[C@H]2C2CC2)C1=O CHEMBL5073432 IC50 51.0 nM
CNC(=O)N1CCCc2ccc(NC(=O)c3ccc(-c4ccn(C(C)=O)n4)cc3)cc21 CHEMBL4776578 IC50 52.3 nM
CNC(=O)N1CCCc2ccc(NC(=O)c3ccc(-c4cccnc4)cc3)cc21 CHEMBL4779896 IC50 53.7 nM
COc1ccn2c(C(C)=O)cc(C(=O)Nc3cc(Cl)cc(-c4cnn(C)c4)c3F)c2c1 CHEMBL5207470 IC50 55.23 nM
CNC(=O)N1CCCc2ccc(NC(=O)c3cccc(-c4cnn(C)c4)c3)cc21 CHEMBL4783664 IC50 55.4 nM
CC(=O)c1cc(C(=O)Nc2cc(CO)cc(-c3cnn(C)c3)c2F)c2cc(CN)ccn12 CHEMBL5204233 IC50 55.63 nM
CC(=O)N1CCc2c(c(-c3cc(C)cc4ccncc34)nn2C2CCOCC2)C1 CHEMBL4203862 IC50 58.0 nM
CCOc1ccc(C(C)=O)cc1-c1cccc(-c2nn[nH]n2)c1 CHEMBL4206032 IC50 59.0 nM
CNC(=O)N1CCCc2ccc(NC(=O)c3cccc(-c4ccncc4)c3)cc21 CHEMBL4758366 IC50 60.0 nM
C[C@H]1Nc2c(cccc2N2CCCc3cc(-c4cnn(C)c4)c(C(F)F)cc32)NC1=O CHEMBL4064118 IC50 61.0 nM
CNC(=O)N1CCCc2cc(NC(=O)c3cccc(-c4ccncc4)c3)ccc21 CHEMBL5434919 IC50 63.0 nM
CC[C@]1(O)C[C@@H]2CN(CCc3c([nH]c4ccccc34)[C@](C(=O)OC)(c3cc4c(cc3OC)N(C)[C@H]3[C@](O)(C(=O)OC)[C@@H](C(=O)OC)[C@@]5(CC)C=CCN6CC[C@@]43[C@@H]65)C2)C1 CHEMBL1610129 Potency 63.1 nM
CC(=O)N1CCc2c(c(-c3ccc(CO)c4ccncc34)nn2C2CCOCC2)C1 CHEMBL4214660 IC50 65.0 nM
Cn1cc(-c2cc3c(cc2C(F)F)N(c2ccc4sc(=O)n(C)c4c2)CCC3)cn1 CHEMBL4081585 IC50 69.0 nM
CC(=O)N1CCc2c(c(-c3cc(CO)cc4ccncc34)nn2C2CCOCC2)C1 CHEMBL4210701 IC50 69.0 nM
COc1cc(-c2nn(C3CCOCC3)c3c2CN(C(C)=O)CC3)c2cnccc2c1 CHEMBL4215815 IC50 69.0 nM
CNC(=O)Nc1ccc2c(c1)CCC[C@@]21OC(=O)N(CC(=O)N2Cc3cc(F)ccc3OC[C@H]2C2CC2)C1=O CHEMBL5083262 IC50 69.0 nM
COc1ccn2c(C(C)=O)cc(C(=O)Nc3cc(F)cc(-c4cnn(C)c4)c3F)c2c1 CHEMBL5179738 IC50 69.65 nM
COc1ccc(CCc2nc3cc(-c4c(C)noc4C)ccn3c2NC2CCCCC2)cc1Cl CHEMBL4853072 IC50 72.0 nM
CNC(=O)N1CCCc2ccc(NC(=O)c3ccc(-c4ccn(S(C)(=O)=O)n4)cc3)cc21 CHEMBL4784945 IC50 74.4 nM
Cc1noc(C)c1-c1ccc2c(c1)nc([C@@H]1CCO[C@H]1c1ccccc1)n2CCN1CCOCC1 CHEMBL4066064 IC50 76.0 nM
CNC(=O)N1CCCc2ccc(NC(=O)c3cccc(-c4cnn(S(C)(=O)=O)c4)c3)cc21 CHEMBL4755549 IC50 76.5 nM
C[C@@H]1CC(=O)Nc2cccc(-c3ccc4c(c3)c(C(N)=O)nn4C)c2N1 CHEMBL3813929 IC50 77.0 nM
CCC(=O)c1cc(C(=O)Nc2cc(CO)cc(-c3cnn(C)c3)c2F)c2cc(O)ccn12 CHEMBL5181127 IC50 78.46 nM
CC(=O)N1CCc2c(c(-c3cccc4c[nH]c(=O)cc34)nn2C2CCOCC2)C1 CHEMBL4218809 IC50 79.0 nM
CC(=O)c1cc(C(=O)Nc2cc(C(C)O)cc(-c3cnn(C4CC4)c3)c2F)c2cc(O)ccn12 CHEMBL5192554 IC50 79.01 nM
CC(=O)N1CCc2c(c(-c3cccc4c3CC(=O)NC4)nn2C2CCOCC2)C1 CHEMBL4204263 IC50 81.0 nM
CC(=O)N1CCc2c(c(-c3cccc4c(CO)cncc34)nn2C2CCOCC2)C1 CHEMBL4210047 IC50 81.0 nM
CNC(=O)N1CCCc2ccc(NC(=O)c3ccc(-c4cnn(C(C)=O)c4)cc3)cc21 CHEMBL4778341 IC50 85.2 nM
CNC(=O)N1CCCc2ccc(NC(=O)c3ccc(-c4ccncc4)cc3)cc21 CHEMBL4756910 IC50 89.2 nM
Cc1noc(C)c1-c1ccc2c(c1)nc(CCc1ccc(N)cc1)n2CCN1CCOCC1 CHEMBL4074125 IC50 90.0 nM
CC(=O)N1CCc2c(c(-c3cncc4ccccc34)nn2C2CCOCC2)C1 CHEMBL4203693 IC50 90.0 nM
CC(=O)N1CCc2c(c(-c3ccc(Cl)c4ccncc34)nn2C2CCOCC2)C1 CHEMBL4214949 IC50 90.0 nM
CNC(=O)N1CCCc2ccc(NC(=O)c3cccc(-c4cn[nH]c4)c3)cc21 CHEMBL4743523 IC50 91.3 nM
CNC(=O)N1CCCc2ccc(NC(=O)c3cccc(-c4cc[nH]n4)c3)cc21 CHEMBL4792407 IC50 92.9 nM
CNC(=O)N1CCCc2ccc(NC(=O)c3ccc(-c4cnn(S(C)(=O)=O)c4)cc3)cc21 CHEMBL4791402 IC50 93.1 nM
CNC(=O)N1CCCc2ccc(NC(=O)c3cccc(-c4ccn(S(C)(=O)=O)n4)c3)cc21 CHEMBL4740324 IC50 94.6 nM
c1ccc2[nH]c(CSc3ncnc4c3oc3ccccc34)nc2c1 CHEMBL1350581 Potency 100.0 nM
COc1ccc2c(c1)N(CCC/C=C/c1cccc3c1N[C@H](C)CC(=O)N3)CCC2 CHEMBL5089448 pKd 100.0 nM
CNC(=O)N1CCCc2ccc(NC(=O)c3ccc(-c4ccccn4)cc3)cc21 CHEMBL4755792 IC50 102.0 nM
COc1ccc2c(c1)N(CCC/C=C/c1cccc3c1N[C@@H](C)C(=O)N3)CCC2 CHEMBL5439570 Kd 102.0 nM
CNC(=O)N1CCCc2ccc(NC(=O)c3cccc(-c4ccn(C(C)=O)n4)c3)cc21 CHEMBL4783911 IC50 103.2 nM
C[C@@H]1CC(=O)Nc2cccc(-c3cccc(OCc4ccccc4)c3)c2N1 CHEMBL3813846 IC50 110.0 nM
CCS(=O)(=O)Nc1cc(-c2cn(C)c3c(=O)[nH]ccc23)cc2c1ccn2C(C)(c1ccccn1)c1ccccn1 CHEMBL4648912 Kd 110.0 nM
CNC(=O)Nc1cc(OC)cc(N2CCCc3cc(-c4cnn(C)c4)c(C(F)F)cc32)n1 CHEMBL4068063 IC50 120.0 nM
CC(=O)N1CCc2c(c(-c3cccc4[nH]ccc34)nn2C2CCOCC2)C1 CHEMBL4210763 IC50 120.0 nM
COc1cc(-c2nnc3sc(C4CCCCC4)nn23)cc(OC)c1OC CHEMBL1416062 Potency 125.9 nM
COc1ccc(-c2cccc3c2N[C@H](C)CC(=O)N3)cc1OC CHEMBL3814246 IC50 130.0 nM
Cc1noc(C)c1-c1ccc2c(c1)nc(-c1cnn3c1CCC3)n2CCN1CCOCC1 CHEMBL4101368 IC50 130.0 nM
CCCOc1ccc(CCc2nc3cc(-c4c(C)noc4C)ccc3n2CCN2CCOCC2)cc1 CHEMBL3963965 IC50 130.0 nM
CCOc1ccc(CCc2nc3cc(-c4c(C)noc4C)ccc3n2CCN2CCOCC2)cc1 CHEMBL4066476 IC50 130.0 nM
CC(=O)N1CCc2c(c(-c3ccnc4ccccc34)nn2C2CCOCC2)C1 CHEMBL4206026 IC50 130.0 nM
Cc1noc(C)c1-c1ccc2c(c1)nc([C@H]1CCO[C@@H]1c1ccccc1)n2CCN1CCOCC1 CHEMBL4093638 IC50 140.0 nM
COc1ccc2c(c1)c(C(=O)Nc1cc(C(=O)O)cc(-c3ccco3)c1)cn2C(C)=O CHEMBL4173925 IC50 140.0 nM
CCOc1ccc(C(C)=O)cc1-c1cc(NC(=O)c2ccco2)cc(-c2c(C)on(C)c2=O)c1 CHEMBL4203144 IC50 140.0 nM
CCOc1ccc(C(C)=O)cc1-c1cc(NC(=O)c2ccco2)cc(-c2c(C)on(CC)c2=O)c1 CHEMBL4202606 IC50 146.0 nM
CC(=O)N1CCc2c(c(Nc3ccccc3)nn2CC2CC2)C1 CHEMBL4215879 IC50 150.0 nM
CCC(=O)N1CCOc2c(cc(-c3ccc(OC)c(OC)c3)cc2OC[C@H]2CCCN(C)C2)C1 CHEMBL3774655 Kd 151.0 nM
COc1ccc2c(c1)N(CCCC#Cc1cccc3c1N[C@H](C)CC(=O)N3)CCC2 CHEMBL5085843 Kd 154.0 nM
COc1cc2c(cc1OC)-c1c(OC)c(OC)cc3ccnc(c13)C2=O CHEMBL470881 Potency 158.5 nM
COc1ccc(CCc2nc3cc(-c4c(C)noc4C)ccn3c2NC2CCCCC2)cc1 CHEMBL4867046 IC50 159.0 nM
CC(c1ccccc1)n1cc(-c2cccc3c2N[C@H](C)CC(=O)N3)cn1 CHEMBL3815023 IC50 160.0 nM
Cc1noc(C)c1-c1ccc2c(c1)nc(CCc1ccc3ccccc3n1)n2CCN1CCOCC1 CHEMBL4063290 IC50 160.0 nM
COc1ccc2c(c1)c(C(=O)Nc1cc(C(=O)O)cc(-c3cnn(C)c3)c1)cn2C(C)=O CHEMBL4163872 IC50 160.0 nM
CCOc1ccc(C(C)=O)cc1NC(=O)c1cc(C(=O)O)cc(-c2ccoc2)c1 CHEMBL3770598 Kd 170.0 nM
COc1ccc(CCc2cc3nc(-c4c(C)noc4C)ccc3n2CCN2CCOCC2)cc1 CHEMBL4074405 IC50 170.0 nM
CC(=O)n1cc(C(=O)Nc2cc(C(=O)O)cc(-c3ccco3)c2)c2cc(O)ccc21 CHEMBL4165995 IC50 170.0 nM
CC(=O)N1CCc2c(c(-c3cc(Cl)cc4ccncc34)nn2C2CCOCC2)C1 CHEMBL4207560 IC50 170.0 nM
Cc1ccc2ncccc2c1-c1cc(-c2c(C)noc2C)cc2nc(C3CC3)[nH]c12 CHEMBL3926851 Kd 170.0 nM
CC(=O)N1CCc2c(c(-c3cccc4c(C#N)cncc34)nn2C2CCOCC2)C1 CHEMBL4215949 IC50 180.0 nM
C[C@@H]1CC(=O)Nc2cccc(/C=C/c3ccccc3S(N)(=O)=O)c2N1 CHEMBL4762972 IC50 180.0 nM
CC(=O)N1CCc2c(c(-c3nccc4ccccc34)nn2C2CCOCC2)C1 CHEMBL4202407 IC50 190.0 nM
CNC(=O)N1CCCc2ccc(NC(=O)c3ccc(-c4ccccc4)cc3)cc21 CHEMBL4776036 IC50 195.0 nM
Cc1nnc2c3ccccc3c(-c3ccc(N4CCOCC4)c(NS(=O)(=O)c4ccccc4Cl)c3)nn12 CHEMBL3108801 pIC50 199.53 nM
CC(=O)Nc1ccc(CCc2nc3cc(-c4c(C)noc4C)ccc3n2CCN2CCOCC2)cc1 CHEMBL4085966 IC50 200.0 nM
Cc1noc(C)c1-c1ccc2c(c1)nc(CCc1ccc(OC(C)C)cc1)n2CCN1CCOCC1 CHEMBL4075074 IC50 200.0 nM
COc1cc(-c2ccc3c(c2)nc(CCc2ccccc2)n3CCN2CCOCC2)cccc1=O CHEMBL4103593 IC50 210.0 nM
Cc1noc(C)c1-c1ccc2c(c1)nc(CCc1ccc(N(C)C)cc1)n2CCN1CCOCC1 CHEMBL4094643 IC50 210.0 nM
CCOc1ccc(CCc2nc3cc(-c4c(C)noc4C)ccn3c2NC2CCCCC2)cc1 CHEMBL4859434 IC50 214.0 nM
CCOC(=O)c1cnc2ccc(C(=O)OC)cc2c1Nc1cccc(C(=O)O)c1 CHEMBL1621052 IC50 230.0 nM
CCc1c(C(=O)NCc2c(O)ccc3cccc(O)c23)[nH]c(C)c1C(C)=O CHEMBL4741587 Kd 230.0 nM
CCC1C(C(=O)NCc2c(O)ccc3cccc(O)c23)NC(C)C1C(C)=O CHEMBL5394573 Kd 230.0 nM
C[C@@H]1CC(=O)Nc2cccc(-c3ccc4c(cnn4C)c3)c2N1 CHEMBL3814197 IC50 240.0 nM
Cc1noc(C)c1-c1ccc2c(c1)nc(CCc1ccc(O)cc1)n2CCN1CCOCC1 CHEMBL4094017 IC50 240.0 nM
COc1ccc(CCc2nc3cc(-c4c(C)noc4C)ccc3n2CCN2CCOCC2)c(OC)c1 CHEMBL4096429 IC50 240.0 nM
Cc1noc(C)c1-c1ccc2c(c1)nc(CCc1ccccc1)n2CCN1CCOCC1 CHEMBL3753333 IC50 240.0 nM
CC(=O)N1CCc2c(c(-c3ccccc3)nn2CC2CC2)C1 CHEMBL4216533 IC50 240.0 nM
C[C@@H]1CC(=O)Nc2cccc(-c3ccc4c(c3)c(C#N)nn4C)c2N1 CHEMBL3814602 IC50 250.0 nM
CCCCCOC(=O)c1[nH]c2c(c1C)C(=O)CC(c1ccco1)C2 CHEMBL1540099 Potency 251.2 nM
CCCCOc1ccc(CCc2nc3cc(-c4c(C)noc4C)ccc3n2CCN2CCOCC2)cc1 CHEMBL4063726 IC50 260.0 nM
CNC(=O)Nc1cc(OC)cc(NC(=O)NS(=O)(=O)c2cc(C)c(CCOC)s2)n1 CHEMBL1738935 IC50 270.0 nM
CC(=O)N1CCc2c(c(-c3ccc(C#N)c4ccncc34)nn2C2CCOCC2)C1 CHEMBL4210092 IC50 280.0 nM
CNC(=O)N1CCCc2ccc(NC(=O)c3cccc(-c4cnn(C(C)=O)c4)c3)cc21 CHEMBL4780426 IC50 286.1 nM
COc1ccc2c(c1)c(C(=O)Nc1cc(C(=O)O)cc(-c3ccc4c(cnn4C)c3)c1)cn2C(C)=O CHEMBL4174134 IC50 290.0 nM
COc1ccc(CCc2nc3cc(-c4c(C)noc4C)ccn3c2NC(C)C)cc1 CHEMBL4875068 IC50 290.0 nM
Cc1noc(C)c1-c1ccc2c(c1)nc(CCc1ccc(C#N)cc1)n2CCN1CCOCC1 CHEMBL4065507 IC50 300.0 nM
Cc1ccc(O)cc1-n1c(N)c(C(N)=O)c2nc3ccccc3nc21 CHEMBL3321809 IC50 300.0 nM
Cc1cc2c(C(N)=O)c(N)n(-c3c(C)ccc(O)c3C)c2nc1C CHEMBL5199076 IC50 300.0 nM
CCc1noc(C)c1-c1ccc2c(c1)nc(CCc1ccccc1)n2CCN1CCOCC1 CHEMBL4078019 IC50 310.0 nM
COc1cccc(CCc2nc3cc(-c4c(C)noc4C)ccc3n2CCN2CCOCC2)c1 CHEMBL4075476 IC50 310.0 nM
CN(C)C(=O)N1CCc2c(c(N3CCCc4cc(-c5cnn(C)c5)c(C(F)F)cc43)nn2C2CCOCC2)C1 CHEMBL4104751 IC50 310.0 nM
Cn1nc(-c2ccc(N3CCOCC3)c(NS(=O)(=O)c3ccccc3)c2)c2ccccc2c1=O CHEMBL1412930 Potency 316.2 nM
COc1ccc2c(c1)N(CCC/C=C\c1cccc3c1N[C@H](C)CC(=O)N3)CCC2 CHEMBL5085444 pKd 316.23 nM
COc1ccc2c(c1)N(CCCNC(=O)c1cc(C)cc3c1N[C@H](C)C(=O)N3)CCC2 CHEMBL4790788 IC50 320.0 nM
Cc1noc(C)c1-c1ccc2c(c1)nc(CCc1ccccn1)n2CCN1CCOCC1 CHEMBL4064489 IC50 330.0 nM
Cc1noc(C)c1-c1ccc2c(c1)nc(CCc1ccccc1)n2CC(=O)N1CCOCC1 CHEMBL4074676 IC50 360.0 nM
CCOc1ccc(C(C)=O)cc1NC(=O)c1cc(COC2CCCCO2)cc(C(=O)O)c1 CHEMBL3770322 Kd 370.0 nM
Cc1cc(N2C(=O)c3nn(C(C)C)cc3C2c2ccc(Cl)cc2)cn(C)c1=O CHEMBL3650892 IC50 380.0 nM
CCCc1nc2oc3c(NCc4ccccn4)ncnc3c2c2c1COC(C)(C)C2 CHEMBL1389117 Potency 398.1 nM
Cc1cc(N2C(=O)c3nn(C(C)C)c(C)c3C2c2ccc(Cl)cc2)cn(C)c1=O CHEMBL3650913 IC50 400.0 nM
Cc1noc(C)c1-c1ccc2c(c1)nc(CCc1ccncc1)n2CCN1CCOCC1 CHEMBL4077279 IC50 400.0 nM
Cc1noc(C)c1-c1ccc2c(c1)nc(COc1ccccc1)n2CCN1CCOCC1 CHEMBL4104158 IC50 400.0 nM
Cc1c2c(nn1C(C)C)C(=O)N(c1cc(Cl)c(=O)n(C)c1)C2c1ccc(Cl)cc1 CHEMBL3650914 IC50 420.0 nM
Cc1[nH]c(-c2cc(N)ccc2Cl)c2c1C(=O)CCCC2 CHEMBL5439294 Kd 420.0 nM
Cc1cc(C)c2c(=O)n(CC(=O)Nc3ccc(Cl)cc3)sc2n1 CHEMBL1370704 IC50 440.0 nM
CC(C)n1cc2c(n1)C(=O)N(c1cc(Cl)c(=O)n(C)c1)C2c1ccc(Cl)cc1 CHEMBL3650893 IC50 450.0 nM
Cc1noc(C)c1-c1ccc2c(c1)nc1n2[C@H](CN2CCOCC2)C[C@@H]1Cc1ccccc1 CHEMBL4085900 IC50 450.0 nM
CC(=O)N1CCCc2cc(N3CCCc4cc(-c5cnn(C)c5)c(C(F)F)cc43)ccc21 CHEMBL4086422 IC50 450.0 nM
COc1ccc(CCc2nc3cc(-c4c(C)noc4C)ccn3c2NCCN2CCOCC2)cc1 CHEMBL4878741 IC50 460.0 nM
COc1ccc2c(c1)N(CCCNC(=O)c1cccc3c1N[C@H](C)CC(=O)N3)CCC2 CHEMBL5076790 Kd 466.0 nM
COc1ccc(CCc2nc3cc(-c4c(C)noc4C)ccc3n2CCN2CCOCC2)cc1OC CHEMBL4078384 IC50 470.0 nM
C[C@@H]1CC(=O)Nc2cccc(-c3cnn(C(C)(C)C)c3)c2N1 CHEMBL4207557 IC50 470.0 nM
CCOc1ccc(C(C)=O)cc1NC(=O)c1cccc(C(=O)OC)c1 CHEMBL3769500 Kd 490.0 nM
COc1ccc(CCc2c(C#N)c3cc(-c4c(C)noc4C)ccc3n2CCN2CCOCC2)cc1 CHEMBL4078551 IC50 500.0 nM
CCn1cc(-c2ccc3c(c2)nc(CCc2ccccc2)n3CCN2CCOCC2)ccc1=O CHEMBL4068497 IC50 500.0 nM
COc1ccc(Nc2nc(Nc3ccc(OC)cc3)nc(-n3[nH]c(=O)c(C)c3C)n2)cc1 CHEMBL1564501 Potency 501.2 nM
CC[C@]1(O)C[C@@H]2CN(CCc3c([nH]c4ccccc34)[C@](C(=O)OC)(c3cc4c(cc3OC)N(C=O)[C@H]3[C@@](O)(C(=O)OC)[C@H](C(=O)OC)[C@@]5(CC)C=CCN6CC[C@]43[C@H]65)C2)C1 CHEMBL1360944 Potency 501.2 nM
Cc1noc(C)c1-c1ccn2c(NC34CC5CC(CC(C5)C3)C4)c(CCc3ccccc3)nc2c1 CHEMBL4878894 IC50 507.0 nM
COc1cc2c(cc1-c1c(C)noc1C)[nH]c1nc(C)nc(-c3ccnc4ccccc34)c12 CHEMBL4171228 Kd 520.0 nM
CCOc1ccc(C(C)=O)cc1NC(=O)c1cc(COC)cc(C(=O)O)c1 CHEMBL3771341 Kd 530.0 nM
C[C@@H]1CC(=O)Nc2cccc(C(=O)NCc3ccccc3)c2N1 CHEMBL3814891 IC50 530.0 nM
CC(=O)N1CCc2c(cc(-c3cccc(Cl)c3)c(=O)n2CC2CC2)C1 CHEMBL4077375 IC50 540.0 nM
COc1ncc(-n2nc3c(c2C)C(c2ccc(Cl)cc2)N(c2cc(Cl)c(=O)n(C)c2)C3=O)c(OC)n1 CHEMBL3650905 IC50 560.0 nM
CN(C)C(=O)c1cccc(-c2cn(C)c(=O)c3[nH]ccc23)c1 CHEMBL4436408 IC50 560.0 nM
COc1ccc(Cc2nccc3cc(OC)c(OC)cc23)cc1OC CHEMBL19224 Potency 562.3 nM
COc1cccc2c1N(CCCNC(=O)c1cccc3c1N[C@H](C)C(=O)N3)CCC2 CHEMBL4070185 IC50 580.0 nM
CC[C@@H](NC(=O)c1cccc2c1N[C@H](C)CC(=O)N2)c1cnco1 CHEMBL3813915 IC50 620.0 nM
CCn1nc(C)c2c1C(=O)N(c1cc(C)c(=O)n(C)c1)C2c1ccc(Cl)cc1F CHEMBL3654293 IC50 630.0 nM
Cc1nnc2c3ccccc3c(-c3ccc(N4CCOCC4)c(NS(=O)(=O)c4ccc(Cl)cc4)c3)nn12 CHEMBL3108803 pIC50 630.96 nM
Cc1nnc2c3ccccc3c(-c3ccc(N4CCOCC4)c(NS(C)(=O)=O)c3)nn12 CHEMBL3108800 pIC50 630.96 nM
Cn1nc(-c2ccc(N3CCCCC3)c(NC(=O)c3ccco3)c2)c2ccccc2c1=O CHEMBL1565991 Potency 631.0 nM
CC1(C)Cc2c(sc3nc(SCC#N)n(C4CCCCC4)c(=O)c23)CO1 CHEMBL1332683 Potency 631.0 nM
CSc1nc2ccc(Nc3nc(N4CCOCC4)nc(N4CCOCC4)n3)cc2s1 CHEMBL1509321 Potency 631.0 nM
CCCOc1ccc(CCc2nc3cc(-c4c(C)noc4C)ccn3c2NC2CCCCC2)cc1 CHEMBL4875619 IC50 633.0 nM
Cc1nn(C2CCC2)c2c1C(c1ccc(Cl)cc1)N(c1cc(C)c(=O)n(C)c1)C2=O CHEMBL3650940 IC50 650.0 nM
Cc1noc(C)c1-c1ccc2c(c1)nc(CCc1ccc(CCCN(C)C)cc1)n2CCN1CCOCC1 CHEMBL4071814 IC50 650.0 nM
CC(=O)n1cc(C(=O)Nc2cc(C(=O)O)cc(-c3ccco3)c2)c2ccccc21 CHEMBL4159164 IC50 650.0 nM
CC(=O)N1CCc2c(c(-c3cc(C#N)cc4ccncc34)nn2C2CCOCC2)C1 CHEMBL4217633 IC50 650.0 nM
Cc1noc(C)c1-c1ccc2c(c1)nc(CCc1ccc(OCCCN(C)C)cc1)n2CCN1CCOCC1 CHEMBL4210853 IC50 650.0 nM
Cc1cc(N2C(=O)c3nn(C4CC4)c(C(F)(F)F)c3C2c2ccc(Cl)cc2)cn(C)c1=O CHEMBL3650894 IC50 660.0 nM
COc1cc2c(cc1-c1c(C)noc1C)[nH]c1ccnc(-c3c(C4CC4)n[nH]c3C)c12 CHEMBL3581661 Kd 670.0 nM
CCOc1ccc(C(C)=O)cc1NC(=O)c1cccc(C(=O)O)c1 CHEMBL3770150 Kd 670.0 nM
C[C@@H]1CC(=O)Nc2cccc(C(=O)NC3CCOc4ccccc43)c2N1 CHEMBL3814881 IC50 670.0 nM
CNC(=O)Nc1ccc2c(c1)CC[C@@]21OC(=O)N(CC(=O)N2Cc3sc(C)c(C)c3OC[C@H]2C(F)(F)F)C1=O CHEMBL5089370 IC50 680.0 nM
CCCCCOc1ccc(CCc2nc3cc(-c4c(C)noc4C)ccc3n2CCN2CCOCC2)cc1 CHEMBL4085329 IC50 690.0 nM
COc1ccc2c(c1)c(C(=O)Nc1cc(C(=O)O)cc(-c3ccc4c(c3)OCCO4)c1)cn2C(C)=O CHEMBL4163435 IC50 690.0 nM
CCn1cc(C(=O)Nc2ccc3c(c2)OCCO3)c2cc(OC)c(OC)cc2c1=O CHEMBL1497712 Potency 707.9 nM
Cc1noc(C)c1-c1ccn2c(NC3CCCCC3)c(CCc3ccccc3)nc2c1 CHEMBL4848215 IC50 718.0 nM
Cn1cc(N2C(=O)c3nn(C4CC4)c(C(F)(F)F)c3C2c2ccc(Cl)cc2)cc(Cl)c1=O CHEMBL3650891 IC50 740.0 nM
Cc1noc(C)c1-c1ccc2c(c1)nc(CCc1c[nH]c3ccccc13)n2CCN1CCOCC1 CHEMBL4068021 IC50 740.0 nM
CC(=O)N1CCc2[nH]nc(Nc3ccccc3)c2C1 CHEMBL3959584 IC50 740.0 nM
CCn1cc(-c2cccc(C(F)(F)F)c2)c2sc(C(=N)NC3CCS(=O)(=O)CC3)cc2c1=O CHEMBL3769507 Kd 740.0 nM
CCN(CC)CCCC(C)NCc1nn2c(-c3ccccc3)nnc2s1 CHEMBL4758202 IC50 744.3 nM
COc1ccc(CCc2nc3cc(-c4c(C)noc4C)ccn3c2NC2CCCCC2)cc1OC CHEMBL4876541 IC50 750.0 nM
C[C@H]1Nc2c(cccc2C(=O)NCCCN2CCCc3ccccc32)NC1=O CHEMBL4216748 IC50 758.0 nM
Cc1cc2c(c(C(=O)NCCCN3CCCc4ccccc43)c1)N[C@H](C)C(=O)N2 CHEMBL4751783 IC50 760.0 nM
CC(=O)n1cc(C(=O)Nc2cc(C(=O)O)ccc2F)c2ccccc21 CHEMBL4172241 IC50 770.0 nM
Cc1noc(C)c1-c1cc(O)cc([C@@H](O)c2ccccc2)c1 CHEMBL2335154 IC50 771.0 nM
Cc1noc(C)c1-c1ccc2c(c1)nc(CCc1cccnc1)n2CCN1CCOCC1 CHEMBL4092184 IC50 780.0 nM
COC(=O)Nc1nc2cc(C(=O)c3cccs3)ccc2[nH]1 CHEMBL9514 Potency 794.3 nM
COc1cc(NC(=O)c2cccc3c2C(=O)N(Cc2cccnc2)C3)cc(OC)c1OC CHEMBL1579418 Potency 794.3 nM
CCCCNc1c(C(=O)OCC)c(C)nc2c1cnn2CC CHEMBL84567 Potency 794.3 nM
CCOc1cc(C2c3c(oc4cc(C)c(Cl)cc4c3=O)C(=O)N2Cc2ccco2)ccc1O CHEMBL1612870 Potency 794.3 nM
Cc1nn(-c2ccccc2)c2sc(C(=O)N(Cc3ccco3)C(C)C(=O)NC(C)(C)C)cc12 CHEMBL1604912 Potency 794.3 nM
Nc1nc(CSc2n[nH]c(-c3ccccc3)n2)nc(Nc2ccccc2)n1 CHEMBL1526559 Potency 794.3 nM
COc1ccc(S(=O)(=O)Nc2cc(-c3nn4c(C)nnc4c4ccccc34)ccc2N2CCN(C)CC2)cc1 CHEMBL3110353 pIC50 794.33 nM
COCCNC(=O)CCCCn1cc(-c2ccc(NC(=O)C(NCC(C)c3ccc(C#N)cc3)c3ccccc3)nc2)cn1 CHEMBL5413122 IC50 819.0 nM
C[C@@H]1CC(=O)Nc2cccc(C(=O)N[C@H](C)c3ccccc3)c2N1 CHEMBL3813713 IC50 900.0 nM
Cc1ncccc1-n1nc2c(c1C)C(c1ccc(Cl)cc1)N(c1cc(C)c(=O)n(C)c1)C2=O CHEMBL3650929 IC50 920.0 nM
COc1ccc(OCc2nc3cc(-c4c(C)noc4C)ccc3n2CCN2CCOCC2)cc1 CHEMBL4086250 IC50 920.0 nM
COc1ccc(CCc2nc3cc(-c4c(C)noc4C)ccn3c2NC23CC4CC(CC(C4)C2)C3)cc1 CHEMBL4864701 IC50 923.0 nM
CCc1c2c(nn1C1CC1)C(=O)N(c1cc(C)c(=O)n(C)c1)C2c1ccc(Cl)cc1 CHEMBL3650917 IC50 950.0 nM
Cc1noc(C)c1-c1ccn2c(NC(C)(C)C)c(CCc3ccccc3)nc2c1 CHEMBL4848135 IC50 950.0 nM
Cn1cc(N2C(=O)c3nn(C4CC4)cc3C2c2ccc(Cl)cc2)cc(Cl)c1=O CHEMBL3650889 IC50 960.0 nM
CCOc1ccc(C(C)=O)cc1Nc1ccc2c(c1)N(S(C)(=O)=O)CC2 CHEMBL4206088 Kd 970.0 nM
COc1ccccc1CCc1nc2cc(-c3c(C)noc3C)ccc2n1CCN1CCOCC1 CHEMBL4095141 IC50 980.0 nM
Clc1ccc(C2=Nn3c(nnc3-c3[nH]nc4c3CCC4)SC2)cc1Cl CHEMBL1527817 Potency 1000.0 nM
C=CCn1c(=O)/c(=C/c2cc(OC)c(OC)c(OC)c2)s/c1=C(/C#N)c1nc2ccccc2n1C CHEMBL1973866 Potency 1000.0 nM
Cc1nc(SCC(=O)Nc2ccccc2)c2oc3ccccc3c2n1 CHEMBL1372818 Potency 1000.0 nM
Cc1[nH]c(-c2cc(NS(C)(=O)=O)ccc2Oc2ccccc2)c2c1C(=O)CCC2 CHEMBL4063051 IC50 1000.0 nM
Cc1[nH]c(-c2cc(S(C)(=O)=O)ccc2Oc2ccc(F)cc2F)c2c1C(=O)NCC2 CHEMBL3786012 IC50 1000.0 nM
CC(=O)n1cc(C(=O)Nc2cc(COC3CCCCO3)cc(C(=O)O)c2)c2ccccc21 CHEMBL4169942 IC50 1000.0 nM
CC(=O)n1cc(C(=O)Nc2cc(C(=O)O)cc(-c3ccc4c(cnn4C)c3)c2)c2ccccc21 CHEMBL4174306 IC50 1000.0 nM