CN(CC1CCOCC1)c1ncnc2[nH]c(-c3ccc(CCO)cc3)nc12 CHEMBL5415149 IC50 0.2 nM
CC1CCN(c2cc(C3CCNCC3)ccc2NC(=O)c2ccc(C#N)o2)CC1 CHEMBL438533 IC50 0.3 nM
CCc1ccc(-n2cc(C(=O)NOC)c(=O)c3cnc(Nc4ccc(C5CCN(C)CC5)cc4)nc32)cc1 CHEMBL489684 IC50 0.3 nM
CN1CC(c2ccc(NC(=O)c3nc(C#N)c[nH]3)c(C3=CCC(C)(C)CC3)c2)CN(C)C1=O CHEMBL1171604 IC50 0.3 nM
CN(CC1CCOCC1)c1ncnc2[nH]c(-c3ccc(CO)cc3)nc12 CHEMBL5404686 IC50 0.3 nM
CN(Cc1ccccc1F)c1ncnc2[nH]c(-c3ccc(CO)cc3)cc12 CHEMBL5434318 IC50 0.3 nM
CN(Cc1ccccc1O)c1ncnc2[nH]c(-c3ccc(CO)cc3)cc12 CHEMBL5432649 IC50 0.3 nM
Cc1cccc(CN(C)c2ncnc3[nH]c(-c4ccc(C(=O)O)cc4)cc23)c1 CHEMBL5439126 IC50 0.3 nM
Cc1cc(NC(=O)Nc2ccc(-c3ccnc4[nH]nc(N)c34)cc2)ccc1F CHEMBL273187 pKi 0.3162 nM
Cn1nc(N)c2c(-c3ccc(NC(=O)Nc4cccc(Cl)c4)cc3)cncc21 CHEMBL404366 pKi 0.3162 nM
CC1CC=C(c2cc(C3CCNCC3)ccc2NC(=O)c2ncc(C#N)[nH]2)CC1 CHEMBL402337 IC50 0.4 nM
CONC(=O)c1cn(-c2ccc3c(c2)CCC3)c2nc(Nc3ccc(C4CCN(C)CC4)cc3)ncc2c1=O CHEMBL492809 IC50 0.4 nM
CCc1cccc(-n2cc(C(=O)NOC)c(=O)c3cnc(Nc4ccc(C5CCN(C)CC5)cc4)nc32)c1 CHEMBL489881 IC50 0.4 nM
CONC(=O)c1cn(C2CCC(C)(C)CC2)c2nc(Nc3ccc(C4CCN(C)CC4)cc3)ncc2c1=O CHEMBL521580 IC50 0.4 nM
CN1CC(c2ccc(NC(=O)c3nc(C#N)c[nH]3)c(C3=CCC(C)(C)CC3)c2)CN(C)C1=NC#N CHEMBL3349454 IC50 0.4 nM
CN(C)CCNCc1ccc(-c2cc3c(N(C)Cc4ccccc4)ncnc3[nH]2)cc1F CHEMBL5417607 IC50 0.4 nM
COCCOCCOCCOc1ccc(-c2cc3c(N(C)Cc4cccc(C)c4)ncnc3[nH]2)cc1 CHEMBL5425883 IC50 0.4 nM
Cc1cccc(CN(C)c2ncnc3[nH]c(-c4ccc(C(=O)O)c(F)c4)cc23)c1 CHEMBL5405206 IC50 0.4 nM
Cc1cccc(CN(C)c2ncnc3[nH]c(-c4ccc(CCCCC(=O)O)cc4)cc23)c1 CHEMBL5430348 IC50 0.4 nM
Cc1cccc(CN(C)c2ncnc3[nH]c(-c4ccc(S(N)(=O)=O)cc4)cc23)c1 CHEMBL5411617 IC50 0.4 nM
COCCNC(C)(C)c1ccc(NC(=O)c2ncc(C#N)[nH]2)c(C2=CCC(C)(C)CC2)c1 CHEMBL3086320 IC50 0.44 nM
CCONC(=O)c1cn(-c2ccc3c(c2)CCC3)c2nc(Nc3ccc(CCN4CCN(C)CC4)cc3)ncc2c1=O CHEMBL451575 IC50 0.5 nM
CC(C)ONC(=O)c1cn(-c2ccc3c(c2)CCC3)c2nc(Nc3ccc(CCN4CCN(C)CC4)cc3)ncc2c1=O CHEMBL509044 IC50 0.5 nM
CONC(=O)c1cn(-c2ccc3c(c2)CCC3)c2nc(Nc3ccc(C4CCNCC4)cc3)ncc2c1=O CHEMBL489298 IC50 0.5 nM
CN1C(=O)CC(c2ccc(NC(=O)c3nc(C#N)c[nH]3)c(C3=CCCCC3)c2)CC1=O CHEMBL1170784 IC50 0.5 nM
CN1CC(c2ccc(NC(=O)c3nc(C#N)c[nH]3)c(C3=CCCCC3)c2)CN(C)C1=O CHEMBL1170786 IC50 0.5 nM
Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1NC(=O)c1cncc(-c2cnn(C)c2)c1 CHEMBL4084391 IC50 0.5 nM
CN(CC1CCCC1)c1ncnc2[nH]c(-c3ccc(CO)cc3)nc12 CHEMBL5407395 IC50 0.5 nM
Cc1cccc(CN(C)c2ncnc3[nH]c(-c4ccc(CO)cc4)cc23)c1 CHEMBL5406924 IC50 0.5 nM
Cc1cccc(CN(C)c2ncnc3[nH]c(-c4ccc(CO)cc4)cc23)n1 CHEMBL5428404 IC50 0.5 nM
COCCNC(C)(C)c1ccc(NC(=O)c2nc(C#N)c[nH]2)c(C2=CCC(C)(C)CC2)c1 CHEMBL4282165 IC50 0.51 nM
CN(C)c1ccc2c(Oc3ccc(NC(=O)NCc4ccc(C(F)(F)F)nc4)cc3)ncnc2c1 CHEMBL4847875 IC50 0.53 nM
Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1 CHEMBL5416410 IC50 0.57 nM
CC1CCN(c2cc(N3CCN(CCO)CC3)ccc2NC(=O)c2ccc(C#N)o2)CC1 CHEMBL398237 IC50 0.6 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(NC(=O)c3ccc(OC4CCNCC4)cn3)cc2)no1 CHEMBL2203433 Kd 0.6 nM
COCCNCC(C)(C)c1ccc(NC(=O)c2nc(C#N)c[nH]2)c(C2=CCC(C)(C)CC2)c1 CHEMBL3085973 IC50 0.6 nM
CC1=C(c2cc(C(C)(C)N3CCCC3)ccc2NC(=O)c2ncc(C#N)[nH]2)CCCC1C CHEMBL3937254 IC50 0.6 nM
CC1(C)CC=C(c2cc(C(C)(C)N3CCCC3)ccc2NC(=O)c2ncc(C#N)[nH]2)CC1 CHEMBL4294553 IC50 0.6 nM
COc1cc(OCc2ccnc(N)c2Cl)cc2sc(N[C@@H]3CCCC[C@H]3O)nc12 CHEMBL4746711 Kd 0.6 nM
Nc1nccc(COc2ccc3nc(N[C@@H]4CCCC[C@H]4O)sc3c2)c1Cl CHEMBL4759047 Kd 0.6 nM
Cc1cccc(CN(C)c2ncnc3[nH]c(-c4cccc(C(=O)O)c4)cc23)c1 CHEMBL5404033 IC50 0.6 nM
CC(C)(N)CC(=O)N1CCC(c2ccc(NC(=O)c3ncc(C#N)[nH]3)c(C3=CCCCC3)c2)CC1 CHEMBL2158300 IC50 0.62 nM
Nc1n[nH]c2cccc(-c3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12 CHEMBL373798 pKi 0.631 nM
CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)cc1 CHEMBL49120 pKi 0.631 nM
Cc1cccc(NC(=O)Nc2ccc(-c3cncc4[nH]nc(N)c34)cc2)c1 CHEMBL272938 pKi 0.631 nM
CSc1cccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)c1 CHEMBL386051 Kd 0.67 nM
CC(=O)NCCNC(C)(C)c1ccc(C(=O)NOC(=O)c2nc(C#N)c[nH]2)c(C2=CCC(C)(C)CC2)c1 CHEMBL3958194 IC50 0.68 nM
CC(=O)NCCNC(C)(C)c1ccc(NC(=O)c2ncc(C#N)[nH]2)c(C2=CCC(C)(C)CC2)c1 CHEMBL3085977 IC50 0.68 nM
CN(C)CC(=O)N1CCC(c2ccc(NC(=O)c3nc(C#N)c[nH]3)c(C3=CCCCC3)c2)CC1 CHEMBL1908842 IC50 0.69 nM
CC1(C)CC=C(c2cc(C(C)(C)N3CCN(CCO)CC3)ccc2NC(=O)c2ncc(C#N)[nH]2)CC1 CHEMBL3085833 IC50 0.69 nM
CC1(C)CC=C(c2cc(C(C)(C)N3CCN(CCO)CC3)ccc2NC(=O)c2nc(C#N)c[nH]2)CC1 CHEMBL3086324 IC50 0.69 nM
N#Cc1ccc(C(=O)Nc2ccc(N3CCS(=O)(=O)CC3)cc2N2CCCCC2)o1 CHEMBL252822 IC50 0.7 nM
CC(=O)N1CCN(c2ccc(NC(=O)c3cc(C#N)c[nH]3)c(N3CCC(C)CC3)c2)CC1 CHEMBL254909 IC50 0.7 nM
CN1CCN(CCc2ccc(Nc3ncc4c(=O)c(C(=O)NCCO)cn(-c5ccc6c(c5)CCC6)c4n3)cc2)CC1 CHEMBL451918 IC50 0.7 nM
CONC(=O)c1cn(-c2ccc3c(c2)CCC3)c2nc(Nc3ccc(CCN4CCN(C)CC4)cc3)ncc2c1=O CHEMBL505830 IC50 0.7 nM
CONC(=O)c1cn(-c2ccc3c(c2)CCC3)c2nc(Nc3ccc(C4CCN(C)CC4(F)F)cc3)ncc2c1=O CHEMBL445519 IC50 0.7 nM
N#Cc1c[nH]c(C(=O)Nc2ccc(C3CCN(C(=O)NCCO)CC3)cc2C2=CCCCC2)n1 CHEMBL2158302 IC50 0.7 nM
Cc1ccc(C(=O)Nc2ccc(Cl)cc2)cc1C#Cc1cc(-c2cnn(C)c2)cnc1N CHEMBL4576115 IC50 0.7 nM
Cc1ccccc1CN(C)c1ncnc2[nH]c(-c3ccc(CO)cc3)cc12 CHEMBL5417494 IC50 0.7 nM
CC1(C)CC=C(c2cc(CN3CCN(CCO)CC3)ccc2NC(=O)c2nc(C#N)c[nH]2)CC1 CHEMBL3085984 IC50 0.75 nM
CC1(C)CC=C(c2cc(CN3CCN(CCO)CC3)ccc2NC(=O)c2nc(C#N)c[nH]2)CC1 CHEMBL4295208 IC50 0.75 nM
CCN1Cc2c(ccc(F)c2C#N)O[C@@H](C)CNC(=O)c2c(N)nn3ccc1nc23 CHEMBL5095061 IC50 0.76 nM
CC1CCN(c2cc(N3CCN(C)CC3)ccc2NC(=O)c2cc(C#N)c[nH]2)CC1 CHEMBL254702 IC50 0.78 nM
Cc1ccc(F)c(NC(=O)Nc2ccc(-c3cncc4[nH]nc(N)c34)cc2)c1 CHEMBL271441 pKi 0.7943 nM
CN1CCN(c2ccc(NC(=O)c3ccc(C#N)o3)c(N3CCCCC3)c2)CC1 CHEMBL398509 IC50 0.8 nM
CC(=O)N1CCC(c2ccc(NC(=O)c3ccc(C#N)o3)c(N3CCC(C)CC3)c2)CC1 CHEMBL257620 IC50 0.8 nM
CC1CCN(c2cc(C3=CCNCC3)ccc2NC(=O)c2ccc(C#N)o2)CC1 CHEMBL255443 IC50 0.8 nM
CN1CCN(CCc2ccc(Nc3ncc4c(=O)c(C(N)=O)cn(-c5ccc6c(c5)CCC6)c4n3)cc2)CC1 CHEMBL403776 IC50 0.8 nM
CONC(=O)c1cn(-c2ccc3c(c2)CCC3)c2nc(Nc3ccc(CCN4CCNC(=O)C4)cc3)ncc2c1=O CHEMBL448117 IC50 0.8 nM
CONC(=O)c1cn(-c2ccc3c(c2)CCC3)c2nc(Nc3ccc(CCN4CCN(C)C(=O)C4)cc3)ncc2c1=O CHEMBL508935 IC50 0.8 nM
CCN1CCCC(O)(c2cccc(Nc3ncc4c(=O)c(C(=O)NOC)cn(-c5ccc6c(c5)CCC6)c4n3)c2)C1 CHEMBL448339 IC50 0.8 nM
CC1(C)CC=C(c2cc(C3CC(=O)NC(=O)C3)ccc2NC(=O)c2nc(C#N)c[nH]2)CC1 CHEMBL1171385 IC50 0.8 nM
CCN1CCC(Oc2ccc(C(=O)Nc3ccc(NC(=O)Nc4cc(C(C)(C)C)on4)cc3)nc2)CC1 CHEMBL2203434 Kd 0.8 nM
CC1(C)CC=C(c2cc(CCN3CCOCC3)ccc2NC(=O)c2ncc(C#N)[nH]2)CC1 CHEMBL3085978 IC50 0.8 nM
CN(C)CCOC(C)(C)c1ccc(NC(=O)c2ncc(C#N)[nH]2)c(C2=CCC(C)(C)CC2)c1 CHEMBL3086316 IC50 0.8 nM
CN(C)CCOC(C)(C)c1ccc(NC(=O)c2nc(C#N)c[nH]2)c(C2=CCC(C)(C)CC2)c1 CHEMBL4292129 IC50 0.8 nM
CC1(C)CC=C(c2cc(CCN3CCOCC3)ccc2NC(=O)c2ncc(C#N)[nH]2)CC1 CHEMBL4294739 IC50 0.8 nM
COc1cc(OCc2ccnc(Nc3cn[nH]c3)n2)cc2sc(N[C@H]3CCCC[C@@H]3O)nc12 CHEMBL4758092 IC50 0.8 nM
[11CH3]N1CCN(c2ccc(NC(=O)c3ccc(C#N)o3)c(N3CCCCC3)c2)CC1 CHEMBL5189346 IC50 0.8 nM
COCCOCCOCCOc1ccc(-c2cc3c(N(C)Cc4ccccc4)ncnc3[nH]2)cc1 CHEMBL5406771 IC50 0.8 nM
CN(C)CCNCc1cc(-c2cc3c(N(C)Cc4ccccc4)ncnc3[nH]2)ccc1F CHEMBL5422465 IC50 0.8 nM
CC1(C)CC=C(c2cc(CN3CCNCC3)ccc2NC(=O)c2nc(C#N)c[nH]2)CC1 CHEMBL3660802 IC50 0.82 nM
CC1(C)CC=C(c2cc(CN3CCNCC3)ccc2NC(=O)c2nc(C#N)c[nH]2)CC1 CHEMBL4280188 IC50 0.82 nM
COc1cc(Oc2ccnc3cc(OC)c(OC)cc23)ccc1NC(=O)NC(C)c1nccs1 CHEMBL1908396 Kd 0.83 nM
N#Cc1c[nH]c(C(=O)Nc2ccc(C3CCN(C(=O)CNCCO)CC3)cc2C2=CCCCC2)n1 CHEMBL2158288 IC50 0.83 nM
CC1CCN(c2cc(N3CCN(S(C)(=O)=O)CC3)ccc2NC(=O)c2ccc(C#N)o2)CC1 CHEMBL254910 IC50 0.9 nM
CN1CC(c2ccc(NC(=O)c3nc(C#N)c[nH]3)c(C3=CCCCCC3)c2)CN(C)C1=O CHEMBL1171605 IC50 0.9 nM
CC1(C)CC=C(c2cc(C(C)(C)N3CCOCC3)ccc2NC(=O)c2ncc(C#N)[nH]2)CC1 CHEMBL3085828 IC50 0.9 nM
Cc1ncc(NC(=O)c2cccc(C(F)(F)F)c2)cc1NC(=O)c1cncc(-c2cnn(C)c2)c1 CHEMBL4085366 IC50 0.9 nM
Cc1cccc(CN(C)c2ncnc3[nH]c(-c4cccnc4)cc23)c1 CHEMBL5436321 IC50 0.9 nM
CC1(C)CC=C(c2cc(C(C)(C)N3CCN(CC(=O)O)CC3)ccc2NC(=O)c2nc(C#N)c[nH]2)CC1 CHEMBL3705040 IC50 0.93 nM
CC1(C)CC=C(c2cc(C(C)(C)N3CCN(C(=O)[O-])CC3)ccc2NC(=O)c2nc(C#N)c[nH]2)CC1 CHEMBL4286584 IC50 0.93 nM
CC1CCN(c2cc(N3CCN(C)CC3)ccc2NC(=O)c2ccc(C#N)o2)CC1 CHEMBL252436 IC50 1.0 nM
CC1CCN(c2cc(N3CCNCC3)ccc2NC(=O)c2cc(C#N)c[nH]2)CC1 CHEMBL254908 IC50 1.0 nM
N#Cc1cnc(C(=O)Nc2ccc(C3CCNCC3)cc2C2=CCCCC2)[nH]1 CHEMBL257154 IC50 1.0 nM
N#Cc1c[nH]c(C(=O)Nc2ccc(C3CC(=O)NC(=O)C3)cc2C2=CCCCC2)n1 CHEMBL1171777 IC50 1.0 nM
Cc1ccc(F)c(NC(=O)Nc2ccc(-c3cncc4c3c(N)nn4C)cc2)c1 CHEMBL402846 pKi 1.0 nM
Cc1cc(NC(=O)Nc2ccc(-c3cccc4[nH]nc(N)c34)cc2)ccc1F CHEMBL374044 pKi 1.0 nM
CN(CCO)CC(=O)N1CCC(c2ccc(NC(=O)c3nc(C#N)c[nH]3)c(C3=CCCCC3)c2)CC1 CHEMBL2158289 IC50 1.0 nM
CCN1CCC(Cc2ccc(C(=O)Nc3ccc(NC(=O)Nc4cc(C(C)(C)C)on4)cc3)nc2)CC1 CHEMBL2203427 Kd 1.0 nM
CN1C(C)(C)CC(Oc2ccc(C(=O)Nc3ccc(NC(=O)Nc4cc(C(C)(C)C)on4)cc3)nc2)CC1(C)C CHEMBL2206277 Kd 1.0 nM
COc1ccc(COc2ccc(Cn3c(N)nc4cc(-c5ccc(P(C)(C)=O)nc5)ccc43)cc2OC)cc1 CHEMBL3673440 IC50 1.0 nM
Cc1ccc2c(Nc3ccc(Cl)cc3)nccc2c1NC(=O)c1csc2c(N)ncnc12 CHEMBL3969260 IC50 1.0 nM
CN1CCN(c2ccc3nc(-c4c(N)c5c(F)cccc5[nH]c4=O)[nH]c3c2)CC1 CHEMBL522892 IC50 1.0 nM
Cc1ccc(NC(=O)c2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1NC(=O)c1cccc(-c2cnn(C)c2)c1 CHEMBL4095856 IC50 1.0 nM
CNC(=O)c1cc(Oc2ccc3nc(N[C@@H]4CCCC[C@H]4O)sc3c2)ccn1 CHEMBL4227505 IC50 1.0 nM
Nc1nccc(COc2cc(F)c3nc(N[C@@H]4CCCC[C@H]4O)sc3c2)c1Cl CHEMBL4763875 IC50 1.0 nM
Nc1nccc(COc2cc(Cl)c3nc(N[C@@H]4CCCC[C@H]4O)sc3c2)c1Cl CHEMBL4751287 IC50 1.0 nM
COc1cc(OCc2ccnc(Nc3cnn(C)c3)n2)cc2sc(N[C@H]3CCCC[C@@H]3O)nc12 CHEMBL4748740 Kd 1.0 nM
CN(CC1CCCCC1)c1ncnc2[nH]c(-c3ccc(CO)cc3)nc12 CHEMBL5431736 IC50 1.0 nM
CN(Cc1ccccc1)c1ncnc2[nH]c(-c3ccc(CO)cc3)cc12 CHEMBL5431583 IC50 1.0 nM
CN(Cc1ccncc1)c1ncnc2[nH]c(-c3ccc(CO)cc3)cc12 CHEMBL5424694 IC50 1.0 nM
N#Cc1c[nH]c(C(=O)Nc2ccc(C3CCNCC3)cc2C2=CCCCC2)n1 CHEMBL2158221 IC50 1.1 nM
N#Cc1cnc(C(=O)Nc2ccc(C3CCN(CCO)CC3)cc2C2=CCCCC2)[nH]1 CHEMBL2158225 IC50 1.1 nM
N#Cc1cnc(C(=O)Nc2ccc(C3CCN(CCN4CCOCC4)CC3)cc2C2=CCCCC2)[nH]1 CHEMBL2158230 IC50 1.1 nM
N#Cc1c[nH]c(C(=O)Nc2ccc(C3CCN(C(=O)Cc4c[nH]cn4)CC3)cc2C2=CCCCC2)n1 CHEMBL2158293 IC50 1.1 nM
CC1(C)CC=C(c2cc(C(C)(C)N3CC[S+]([O-])CC3)ccc2NC(=O)c2ncc(C#N)[nH]2)CC1 CHEMBL3660762 IC50 1.1 nM
Nc1nccc(COc2ccc3nc(N[C@H]4CCCC[C@H]4O)sc3c2)c1Cl CHEMBL4798876 IC50 1.1 nM
Nc1nccc(COc2ccc3nc(N[C@@H]4CCCC[C@H]4O)sc3c2F)c1Cl CHEMBL4795462 IC50 1.1 nM
Nc1nccc(COc2ccc3nc(N[C@H]4CCCC[C@@H]4O)sc3c2)c1Cl CHEMBL4741283 Kd 1.1 nM
Cc1[nH]c(/C=C2\C(=O)Nc3cc(NC(=O)Nc4cc(C(C)(C)C)on4)ccc32)c(C)c1NC(=O)CCN(C)C CHEMBL5087258 IC50 1.1 nM
CN(Cc1ccccc1)c1ncnc2[nH]c(-c3ccc(CO)cc3)nc12 CHEMBL5413223 IC50 1.1 nM
CN(Cc1ccccn1)c1ncnc2[nH]c(-c3ccc(CO)cc3)cc12 CHEMBL5403478 IC50 1.1 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(NC(=O)c3ccc(OC4CCN(C(C)(C)C)CC4)cn3)cc2)no1 CHEMBL2203437 Kd 1.12 nM
CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL388978 IC50 1.14 nM
CNC(=O)c1cn(-c2ccc3c(c2)CCC3)c2nc(Nc3ccc(CCN4CCN(C)CC4)cc3)ncc2c1=O CHEMBL511484 IC50 1.2 nM
N#Cc1c[nH]c(C(=O)Nc2ccc(C3CCN(C(=O)[C@H](O)CO)CC3)cc2C2=CCCCC2)n1 CHEMBL2158287 IC50 1.2 nM
CC(C)N1CCC(Oc2ccc(C(=O)Nc3ccc(NC(=O)Nc4cc(C(C)(C)C)on4)cc3)nc2)CC1 CHEMBL2203435 Kd 1.2 nM
CC1(C)CC=C(c2cc(C(C)(C)NCCN3CCOCC3)ccc2NC(=O)c2nc(C#N)c[nH]2)CC1 CHEMBL3085976 IC50 1.2 nM
CC1(C)CC=C(c2cc(C(C)(C)OCCN3CCCC3)ccc2NC(=O)c2nc(C#N)c[nH]2)CC1 CHEMBL3086317 IC50 1.2 nM
COc1cc(OCc2ccnc(Nc3cnn(C)c3)n2)c(Cl)c2sc(N[C@H]3CCCC[C@@H]3O)nc12 CHEMBL4740157 IC50 1.2 nM
Nc1nccc(COc2ccc3nc(N[C@@H]4CCCC[C@H]4O)sc3c2Cl)c1Cl CHEMBL4798601 IC50 1.2 nM
Cc1nc(NC(=O)CN2CCN(C)CC2)sc1-c1ccc2c(/C=C/c3ccccn3)n[nH]c2c1 CHEMBL4794404 IC50 1.2 nM
CNC(=O)c1cc(Oc2ccc3nc(N[C@H]4CCCC[C@H]4O)sc3c2)ccn1 CHEMBL4868857 IC50 1.2 nM
Cc1ccc(O)c(CN(C)c2ncnc3[nH]c(-c4ccc(CO)cc4)cc23)c1 CHEMBL5395449 IC50 1.2 nM
Cc1cc(NC(=O)Nc2ccc(-c3c(F)ccc4[nH]nc(N)c34)cc2)ccc1F CHEMBL1993996 pKi 1.259 nM
Cc1ccc(F)c(NC(=O)Nc2ccc(-c3c(F)ccc4[nH]nc(N)c34)cc2)c1 CHEMBL1996255 pKi 1.259 nM
N#Cc1ncc2nc1OCCCCOc1cc(NCc3cncs3)c(Cl)cc1NC(=O)N2 CHEMBL248757 pKi 1.259 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(NC(=O)c3ccc(OC4CCN(C5CC5)CC4)cn3)cc2)no1 CHEMBL2203438 Kd 1.28 nM
CONC(=O)c1cn(-c2ccc3c(c2)CCC3)c2nc(Nc3ccc(CCN4CCOCC4)cc3)ncc2c1=O CHEMBL522834 IC50 1.3 nM
CONC(=O)c1cn(-c2ccc3c(c2)CCC3)c2nc(Nc3ccc(C4CCN(CCO)CC4)cc3)ncc2c1=O CHEMBL451931 IC50 1.3 nM
N#Cc1c[nH]c(C(=O)Nc2ccc(C3CCN(CC(=O)O)CC3)cc2C2=CCCCC2)n1 CHEMBL2158229 IC50 1.3 nM
N#Cc1c[nH]c(C(=O)Nc2ccc(C3CCN(C(=O)c4cc[n+]([O-])cc4)CC3)cc2C2=CCCCC2)n1 CHEMBL2158292 IC50 1.3 nM
N#Cc1c[nH]c(C(=O)Nc2ccc(C3CCN(C(=O)Cc4ccncc4)CC3)cc2C2=CCCCC2)n1 CHEMBL2158297 IC50 1.3 nM
CC(C)(N)C(=O)N1CCC(c2ccc(NC(=O)c3nc(C#N)c[nH]3)c(C3=CCCCC3)c2)CC1 CHEMBL2158301 IC50 1.3 nM
COCCN1CCN(C(C)(C)c2ccc(NC(=O)c3ncc(C#N)[nH]3)c(C3=CCC(C)(C)CC3)c2)CC1 CHEMBL3085834 IC50 1.3 nM
C=C(CNCCOC)c1ccc(NC(=O)c2nc(C#N)c[nH]2)c(C2=CCCCC2)c1 CHEMBL3660791 IC50 1.3 nM
CSCCNCC(C)(C)c1ccc(NC(=O)c2nc(C#N)c[nH]2)c(C2=CCC(C)(C)CC2)c1 CHEMBL3639596 IC50 1.3 nM
C=C(CNCCOC)c1ccc(NC(=O)c2nc(C#N)c[nH]2)c(C2=CCCCC2)c1 CHEMBL4286210 IC50 1.3 nM
Cc1ccc(C(=O)Nc2cccc(Cl)c2)cc1C#Cc1cc(-c2cnn(C)c2)cnc1N CHEMBL4438121 IC50 1.3 nM
Cc1cccc(CN(C)c2ncnc3[nH]c(-c4ccc(CO)cc4)nc23)c1 CHEMBL5410595 IC50 1.3 nM
CN(CC1CCCCO1)c1ncnc2[nH]c(-c3ccc(CO)cc3)nc12 CHEMBL5417420 IC50 1.3 nM
COc1ccc(-c2cc3c(N(C)Cc4ccccc4)ncnc3[nH]2)cc1 CHEMBL5411378 IC50 1.3 nM
COc1ccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(C[C@H](O)CO)c5)cnc(N)c34)cc2)cc1 CHEMBL3646211 IC50 1.34 nM
CNC(=O)c1cn(-c2ccc3c(c2)CCC3)c2nc(Nc3ccc(CCN4CCOCC4)cc3)ncc2c1=O CHEMBL472403 IC50 1.4 nM
N#Cc1c[nH]c(C(=O)Nc2ccc(-c3ccc[n+]([O-])c3)cc2C2=CCCCC2)n1 CHEMBL1172347 IC50 1.4 nM
N#Cc1c[nH]c(C(=O)Nc2ccc(C3CCN(CC(N)=O)CC3)cc2C2=CCCCC2)n1 CHEMBL2158228 IC50 1.4 nM
N#Cc1c[nH]c(C(=O)Nc2ccc(C3CCN(C(=O)c4ccc[n+]([O-])c4)CC3)cc2C2=CCCCC2)n1 CHEMBL2158291 IC50 1.4 nM
N#Cc1cnc(C(=O)Nc2ccc(CCN3CCOCC3)cc2C2=CCCCC2)[nH]1 CHEMBL3086175 IC50 1.4 nM
CC(O)c1ccc(NC(=O)c2nc(C#N)c[nH]2)c(C2=CCC(C)(C)CC2)c1 CHEMBL3086165 IC50 1.4 nM
CSCCNC(C)(C)c1ccc(NC(=O)c2nc(C#N)c[nH]2)c(C2=CCC(C)(C)CC2)c1 CHEMBL3660763 IC50 1.4 nM
COc1cccc(NC(=O)c2ccc(C)c(C#Cc3cc(-c4cnn(C)c4)cnc3N)c2)c1 CHEMBL4534671 IC50 1.4 nM
COc1ccc(NC(=O)c2ccc(C)c(C#Cc3cc(-c4cnn(C)c4)cnc3N)c2)cc1 CHEMBL4452866 IC50 1.4 nM
Cc1[nH]c(/C=C2\C(=O)Nc3cc(NC(=O)Nc4cc(C(C)(C)C)on4)ccc32)c(C)c1NC(=O)CCN1CCN(C)CC1 CHEMBL5090643 IC50 1.4 nM
Cc1[nH]c(/C=C2\C(=O)Nc3cc(NC(=O)Nc4cc(C(C)(C)C)on4)ccc32)c(C)c1NC(=O)CCN1CCCCC1 CHEMBL5090168 IC50 1.4 nM
Cc1[nH]c(/C=C2\C(=O)Nc3cc(NC(=O)Nc4cc(C(C)(C)C)on4)ccc32)c(C)c1NC(=O)CCN1CCCC1 CHEMBL5093379 IC50 1.4 nM
Cc1cccc(CN(C)c2ncnc3[nH]c(-c4ccc(O)cc4)cc23)c1 CHEMBL5397490 IC50 1.4 nM
COc1ccc(-c2cc3c(N(C)Cc4cccc(C)c4)ncnc3[nH]2)cc1F CHEMBL5435513 IC50 1.4 nM
CC(NC(=O)Nc1ccc(Oc2ncnc3cc(N(C)C)ccc23)cc1)c1nccs1 CHEMBL4851545 IC50 1.41 nM
N#Cc1c[nH]c(C(=O)Nc2ccc(CCN3CCOCC3)cc2C2=CCCCC2)n1 CHEMBL4286176 IC50 1.43 nM
N#Cc1c[nH]c(C(=O)Nc2ccc(-c3cc[n+]([O-])cc3)cc2C2=CCCCC2)n1 CHEMBL1172345 IC50 1.5 nM
CS(=O)(=O)CCN1CCC(c2ccc(NC(=O)c3nc(C#N)c[nH]3)c(C3=CCCCC3)c2)CC1 CHEMBL2158227 IC50 1.5 nM
CC1(C)CC=C(c2cc(C(C)(C)CNCCS(C)(=O)=O)ccc2NC(=O)c2ncc(C#N)[nH]2)CC1 CHEMBL3085974 IC50 1.5 nM
CCN1CCN(C(C)(C)c2ccc(NC(=O)c3ncc(C#N)[nH]3)c(C3=CCC(C)(C)CC3)c2)CC1 CHEMBL3085831 IC50 1.5 nM
CC1(C)CC=C(c2cc(C(C)(C)NCCS(C)(=O)=O)ccc2NC(=O)c2nc(C#N)c[nH]2)CC1 CHEMBL3086322 IC50 1.5 nM
CC1(C)CC=C(c2cc(C(=O)O)ccc2NC(=O)c2nc(C#N)c[nH]2)CC1 CHEMBL3086164 IC50 1.5 nM
COC[C@H](O)Cc1ccc(NC(=O)c2ncc(C#N)[nH]2)c(C2=CCC(C)(C)CC2)c1 CHEMBL3967115 IC50 1.5 nM
CC1=C(c2cc(C(C)(C)N3CCCCC3)ccc2NC(=O)c2nc(C#N)c[nH]2)CCCC1C CHEMBL3982086 IC50 1.5 nM
CC1(C)CC=C(c2cc(C(C)(C)N3CCCCC3)ccc2NC(=O)c2ncc(C#N)[nH]2)CC1 CHEMBL3660801 IC50 1.5 nM
CCN1C(C)(C)CC(Oc2ccc(C(=O)Nc3ccc(NC(=O)Nc4cc(C(C)(C)C)on4)cc3)nc2)CC1(C)C CHEMBL2206278 Kd 1.57 nM
CNC(=O)c1cnc(N)c2c(-c3ccc(NC(=O)Nc4cccc(Cl)c4)cc3)csc12 CHEMBL1982476 pKi 1.585 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(C)c5)cnc(N)c34)cc2)c1 CHEMBL1967116 pKi 1.585 nM
Cc1cc(NC(=O)Nc2ccc(-c3cccc4[nH]nc(N)c34)c(F)c2)ccc1F CHEMBL1986979 pKi 1.585 nM
Nc1n[nH]c2nccc(-c3ccc(NC(=O)Nc4cc(C(F)(F)F)ccc4F)cc3)c12 CHEMBL403402 pKi 1.585 nM
Cc1cccc(NC(=O)Nc2ccc(-c3cccc4[nH]nc(N)c34)c(F)c2)c1 CHEMBL1994638 pKi 1.585 nM
COc1ccc(COc2ccc(Cc3cnc(N)nc3N)cc2OC)cc1 CHEMBL261849 Kd 1.6 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(-c3cn4c(n3)sc3cc(OCCN5CCOCC5)ccc34)cc2)no1 CHEMBL576982 Kd 1.6 nM
N#Cc1c[nH]c(C(=O)Nc2ccc(C3CCN(C(CO)CO)CC3)cc2C2=CCCCC2)n1 CHEMBL2158226 IC50 1.6 nM
Cn1cnc(CC(=O)N2CCC(c3ccc(NC(=O)c4nc(C#N)c[nH]4)c(C4=CCCCC4)c3)CC2)c1 CHEMBL2158294 IC50 1.6 nM
Cc1ccc(C(=O)Nc2ccc(NC(=O)Nc3cc(C(C)(C)C)on3)cc2)nc1 CHEMBL2203430 Kd 1.6 nM
CC1(C)CC=C(c2cc(CCS(N)(=O)=O)ccc2NC(=O)c2nc(C#N)c[nH]2)CC1 CHEMBL3086176 IC50 1.6 nM
C=C(CNC)c1ccc(NC(=O)c2nc(C#N)c[nH]2)c(C2=CCCCC2)c1 CHEMBL3660792 IC50 1.6 nM
C=C(CNC)c1ccc(NC(=O)c2nc(C#N)c[nH]2)c(C2=CCCCC2)c1 CHEMBL4281126 IC50 1.6 nM
Cc1nc(-c2cnc(NC(C)C)[nH]c2=O)ccc1Oc1ccnc(-c2cnn(C)c2)c1 CHEMBL5193071 IC50 1.6 nM
CN1CCN(c2ccc(NC(=O)c3cc(C#N)c[nH]3)c(N3CCCCC3)c2)CC1 CHEMBL399763 IC50 1.7 nM
CONC(=O)c1cn(-c2ccc3c(c2)CCC3)c2nc(Nc3ccc(CCN4CCC(F)(F)CC4)cc3)ncc2c1=O CHEMBL455591 IC50 1.7 nM
CN1CC(c2ccc(NC(=O)c3nc(C#N)c[nH]3)c(C3=CCCCC3)c2)CN(C)S1(=O)=O CHEMBL1171607 IC50 1.7 nM
N#Cc1c[nH]c(C(=O)Nc2ccc(C3CCN(C(=O)Cc4cccnc4)CC3)cc2C2=CCCCC2)n1 CHEMBL2158296 IC50 1.7 nM
N#Cc1c[nH]c(C(=O)Nc2ccc(C3CCN(C(=O)CCN4CCOCC4)CC3)cc2C2=CCCCC2)n1 CHEMBL2158298 IC50 1.7 nM
CC(=O)N1CCN(C(C)(C)c2ccc(NC(=O)c3nc(C#N)c[nH]3)c(C3=CCC(C)(C)CC3)c2)CC1 CHEMBL3085832 IC50 1.7 nM
CC1(C)CC=C(c2cc(CCC(N)=O)ccc2NC(=O)c2nc(C#N)c[nH]2)CC1 CHEMBL3085981 IC50 1.7 nM
COCCN(C)C(C)(C)c1ccc(NC(=O)c2ncc(C#N)[nH]2)c(C2=CCC(C)(C)CC2)c1 CHEMBL3086321 IC50 1.7 nM
CC1CN(C(C)c2ccc(NC(=O)c3nc(C#N)c[nH]3)c(C3=CCC(C)(C)CC3)c2)CC(C)N1 CHEMBL3906636 IC50 1.7 nM
Cc1ccc(NC(=O)c2ccc(CN3CCNCC3)c(C(F)(F)F)c2)cc1NC(=O)c1cccc(-c2cnn(C)c2)c1 CHEMBL4074076 IC50 1.7 nM
CC(c1ccc(NC(=O)c2ncc(C#N)[nH]2)c(C2=CCC(C)(C)CC2)c1)N1C[C@@H](C)N[C@@H](C)C1 CHEMBL3660800 IC50 1.7 nM
Cc1[nH]c(/C=C2\C(=O)Nc3cc(NC(=O)Nc4cc(C(C)(C)C)on4)ccc32)c(C)c1NC(=O)[C@@H]1CCNC1 CHEMBL5079480 IC50 1.7 nM
FC(F)(F)c1ccc(CNc2ccc(Cc3c[nH]c4ncc(Cl)cc34)cn2)cn1 CHEMBL3813873 IC50 1.7 nM
C[C@H](c1ccccc1)N(C)c1ncnc2[nH]c(-c3ccc(CO)cc3)cc12 CHEMBL5440766 IC50 1.7 nM
COc1cc2c(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3F)ccnc2cc1OCCCN1CCOCC1 CHEMBL1230609 Kd 1.8 nM
N#CCCN1CCC(c2ccc(NC(=O)c3nc(C#N)c[nH]3)c(C3=CCCCC3)c2)CC1 CHEMBL2158223 IC50 1.8 nM
CC1(C)CC(Oc2ccc(C(=O)Nc3ccc(NC(=O)Nc4cc(C(C)(C)C)on4)cc3)nc2)CC(C)(C)N1 CHEMBL2206279 Kd 1.8 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(NC(=O)c3cc(OC4CCNCC4)ccn3)cc2)no1 CHEMBL2203431 Kd 1.8 nM
Cc1ccccc1CN(C)c1ncnc2[nH]c(-c3ccc(CO)cc3)nc12 CHEMBL5435576 IC50 1.8 nM
Cc1cccc(CN(C)c2ncnc3[nH]c(-c4ccccc4)cc23)c1 CHEMBL5398778 IC50 1.8 nM
Cc1cccc(C(=O)Nc2cccc([C@H](C)Nc3cncc(Cl)n3)c2)c1 CHEMBL504075 Kd 1.9 nM
CN1CC(c2ccc(NC(=O)c3nc(C#N)c[nH]3)c(C3=CCC(C)(C)CC3)c2)CN(C)C1=NS(C)(=O)=O CHEMBL1169980 IC50 1.9 nM
CC1(C)CC=C(c2cc(C(C)(C)OCCN3CCOCC3)ccc2NC(=O)c2ncc(C#N)[nH]2)CC1 CHEMBL3086318 IC50 1.9 nM
CC1(C)CC=C(c2cc(C(C)(C)O)ccc2NC(=O)c2nc(C#N)c[nH]2)CC1 CHEMBL3086315 IC50 1.9 nM
CC1(C)CC=C(c2cc(S(N)(=O)=O)ccc2NC(=O)c2nc(C#N)c[nH]2)CC1 CHEMBL3086167 IC50 1.9 nM
Nc1nccc(COc2ccc3nc(N[C@@H]4CCCC[C@@H]4O)sc3c2)c1Cl CHEMBL4756510 Kd 1.9 nM
CCNCCC(=O)Nc1c(C)[nH]c(/C=C2\C(=O)Nc3cc(NC(=O)Nc4cc(C(C)(C)C)on4)ccc32)c1C CHEMBL5087146 IC50 1.9 nM
Nc1n[nH]c2cccc(-c3ccc(NC(=O)Nc4cccc(Cl)c4)c(F)c3)c12 CHEMBL2000652 pKi 1.995 nM
Cc1cccc(NC(=O)Nc2ccc(-c3coc4ncnc(N)c34)cc2)c1 CHEMBL1983963 pKi 1.995 nM
Cn1cc(-c2cnc(N)c3c(-c4ccc(NC(=O)Nc5cccc(F)c5)cc4)csc23)cn1 CHEMBL1970317 pKi 1.995 nM
Cc1ccc(F)c(NC(=O)Nc2ccc(-c3cccc4c3c(N)nn4C)cc2)c1 CHEMBL1985491 pKi 1.995 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4ncnc(N)c34)cc2)c1 CHEMBL196363 pKi 1.995 nM
Cc1cc(C)cc(NC(=O)Nc2ccc(-c3ccnc4c3c(N)nn4C)cc2)c1 CHEMBL1986507 pKi 1.995 nM
Cc1cccc(NC(=O)Nc2ccc(-c3cncc4c3c(N)nn4C)cc2)c1 CHEMBL404367 IC50 2.0 nM
CC(=O)N1CCC(c2ccc(NC(=O)c3ncc(C#N)[nH]3)c(C3=CCCCC3)c2)CC1 CHEMBL256712 IC50 2.0 nM
CC1CCN(c2cc(/C=C/C(=O)O)ccc2NC(=O)c2ccc(C#N)o2)CC1 CHEMBL261699 IC50 2.0 nM
COc1cc2ncc(C(N)=O)c(Nc3ccc(Cl)c(Cl)c3)c2cc1N1CCN(C)CC1 CHEMBL481423 IC50 2.0 nM
Cc1ccc(F)c(C(=O)Nc2cccc([C@H](C)Nc3cncc(Cl)n3)c2)c1 CHEMBL474695 IC50 2.0 nM
CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C CHEMBL535 Kd 2.0 nM
Cc1ccnc(C(=O)Nc2ccc(NC(=O)Nc3cc(C(C)(C)C)on3)cc2)c1 CHEMBL2203429 Kd 2.0 nM
CC1(C)CC=C(c2cc(C(C)(C)CN3CCN(CCO)CC3)ccc2NC(=O)c2ncc(C#N)[nH]2)CC1 CHEMBL3085975 IC50 2.0 nM
CC1(C)CC=C(c2cc(C(C)(C)CO)ccc2NC(=O)c2nc(C#N)c[nH]2)CC1 CHEMBL3085969 IC50 2.0 nM
CC1(C)CC=C(c2cc(Cc3nnn[nH]3)ccc2NC(=O)c2nc(C#N)c[nH]2)CC1 CHEMBL3086160 IC50 2.0 nM
COc1ccc(COc2ccc(Cn3c(N)nc4cc(-c5cnn(C)c5)ccc43)cc2OC)cc1 CHEMBL3673436 IC50 2.0 nM
COc1ccc(COc2ccc(Cn3c(N)nc4cc(-c5ccncc5)ccc43)cc2OC)cc1 CHEMBL3673438 IC50 2.0 nM
COc1ccc(COc2ccc(Cn3cnc4cc(-c5cnn(C6CCNCC6)c5)ccc43)cc2OC)cn1 CHEMBL3673442 IC50 2.0 nM
COc1ccc(COc2ccc(Cn3c(N)nc4cc(-c5cnn(C)c5)cnc43)cc2OC)cc1 CHEMBL3673452 IC50 2.0 nM
COc1ccc(COc2ccc(Cn3c(N)nc4cc(-c5ccc(P(C)(C)=O)nc5)cnc43)cc2OC)cc1 CHEMBL3673453 IC50 2.0 nM
COc1ccc(COc2ccc(Cn3cnc4cc(-c5cnn(C6CCNCC6)c5)cnc43)cc2OC)cn1 CHEMBL3673462 IC50 2.0 nM
COc1ccc(COc2ccc(Cn3c(N)nc4cc(-c5ccncc5)cnc43)cc2OC)cn1 CHEMBL3673486 IC50 2.0 nM
Cc1nc(NC(=O)N2CCN(C3CCCC3)C2=O)ccc1Oc1ccnc(-c2cnn(C)c2)c1 CHEMBL3931177 IC50 2.0 nM
CCOC(=O)CN1CCN(C(C)(C)c2ccc(NC(=O)c3ncc(C#N)[nH]3)c(C3=CCC(C)(C)CC3)c2)CC1 CHEMBL3660796 IC50 2.0 nM
CNC(=O)c1cc(Oc2ccc3nc(N[C@H]4CCCC[C@@H]4O)sc3c2)ccn1 CHEMBL4065459 IC50 2.0 nM
CCC(=O)N1CC[C@H](N2C(=O)N(c3cc(OC)ccc3F)Cc3cnc(Nc4ccc(N5CCN(C)CC5)c(C)c4)nc32)C1 CHEMBL4096822 IC50 2.0 nM
Cc1cccc(Cn2nc(C)c3c(NC(=O)c4csc5c(N)ncnc45)cccc32)n1 CHEMBL4483816 IC50 2.0 nM
COc1cc(OCc2ccnc(N)n2)c(Cl)c2sc(N[C@H]3CCCC[C@@H]3O)nc12 CHEMBL4779878 IC50 2.0 nM
Cc1[nH]c(/C=C2\C(=O)Nc3cc(NC(=O)Nc4cc(C(C)(C)C)on4)ccc32)c(C)c1NC(=O)C1CCCCN1 CHEMBL5072690 IC50 2.0 nM
Cc1nc(-c2cnc(NC3CC3)n(C)c2=O)ccc1Oc1ccnc(-c2cnn(C)c2)c1 CHEMBL5183210 IC50 2.0 nM
COCCOc1ccc(-c2cc3c(N(C)Cc4ccccc4)ncnc3[nH]2)cc1 CHEMBL5439547 IC50 2.0 nM
CCc1ccc(-c2c(-c3cnc(C)[nH]3)c(=O)[nH]c3ccc(Cl)cc23)cc1 CHEMBL403661 IC50 2.1 nM
CCC(=O)N1CC[C@H](N2C(=O)N(c3cc(OC)ccc3Cl)Cc3cnc(Nc4ccc(N5CCN(C)CC5)c(C)c4)nc32)C1 CHEMBL4084726 IC50 2.1 nM
Cc1[nH]c(/C=C2\C(=O)Nc3cc(NC(=O)Nc4cc(C(C)(C)C)on4)ccc32)c(C)c1NC(=O)CN1CCN(C)CC1 CHEMBL5079522 IC50 2.1 nM
CN(Cc1ccccc1)c1ncnc2[nH]c(-c3ccc(F)c(CO)c3)cc12 CHEMBL5432592 IC50 2.1 nM
CONC(=O)c1cn(-c2ccc3c(c2)CCC3)c2nc(Nc3ccc(C4CCN(CC(=O)O)CC4)cc3)ncc2c1=O CHEMBL452965 IC50 2.2 nM
CC1(C)CC=C(c2cc(C(N)=O)ccc2NC(=O)c2nc(C#N)c[nH]2)CC1 CHEMBL3086162 IC50 2.2 nM
Cc1[nH]c(/C=C2\C(=O)Nc3cc(NC(=O)Nc4cc(C(C)(C)C)on4)ccc32)c(C)c1NC(=O)C1CCCNC1 CHEMBL5091174 IC50 2.2 nM
CN(Cc1ccncc1)c1ncnc2[nH]c(-c3ccc(CO)cc3)nc12 CHEMBL5403333 IC50 2.2 nM
Nc1ncc(-c2cnn(CCO)c2)c2scc(-c3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12 CHEMBL1980297 IC50 2.22 nM
N#Cc1c[nH]c(C(=O)Nc2ccc(-c3cccnc3)cc2C2=CCCCC2)n1 CHEMBL1172528 IC50 2.3 nM
N#Cc1c[nH]c(C(=O)Nc2ccc(C3CNC(=O)NC3)cc2C2=CCCCC2)n1 CHEMBL1170785 IC50 2.3 nM
CN1CCN(C(C)(C)c2ccc(NC(=O)c3ncc(C#N)[nH]3)c(C3=CCC(C)(C)CC3)c2)CC1 CHEMBL3085830 IC50 2.3 nM
CC1(C)CC=C(c2cc(S(C)(=O)=O)ccc2NC(=O)c2nc(C#N)c[nH]2)CC1 CHEMBL3086166 IC50 2.3 nM
CCCNCCC(=O)Nc1c(C)[nH]c(/C=C2\C(=O)Nc3cc(NC(=O)Nc4cc(C(C)(C)C)on4)ccc32)c1C CHEMBL5080482 IC50 2.3 nM
CN(Cc1ccccc1F)c1ncnc2[nH]c(-c3ccc(CO)cc3)nc12 CHEMBL5429835 IC50 2.3 nM
CN(Cc1ccccc1O)c1ncnc2[nH]c(-c3ccc(CO)cc3)nc12 CHEMBL5410355 IC50 2.3 nM
CONC(=O)c1cn(-c2ccc3c(c2)CCC3)c2nc(Nc3ccc(CCS(=O)(=O)NC(C)=O)cc3)ncc2c1=O CHEMBL444454 IC50 2.4 nM
N#Cc1c[nH]c(C(=O)Nc2ccc(C3CCN(Cc4ccccn4)CC3)cc2C2=CCCCC2)n1 CHEMBL2158224 IC50 2.4 nM
N#Cc1c[nH]c(C(=O)Nc2ccc(CCS(N)(=O)=O)cc2C2=CCCCC2)n1 CHEMBL3085982 IC50 2.4 nM
CC1(C)CC=C(c2cc(CC(=O)NCCCO)ccc2NC(=O)c2ncc(C#N)[nH]2)CC1 CHEMBL3086172 IC50 2.4 nM
CC1(C)CC=C(c2nc(CC(=O)NCCCO)ccc2NC(=O)c2ncc(C#N)[nH]2)CC1 CHEMBL4293523 IC50 2.4 nM
Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1C#Cc1cc(-c2cnn(C)c2)cnc1N CHEMBL4517659 IC50 2.4 nM
Cc1ccc(CN(C)c2ncnc3[nH]c(-c4ccc(CO)cc4)cc23)cc1 CHEMBL5414964 IC50 2.4 nM
CCc1ccc(-c2c(-c3cnc(C)[nH]3)c(=O)[nH]c3ccc(C#N)cc23)cc1 CHEMBL273198 IC50 2.5 nM
CC1(C)CC=C(c2cc(C3CNC(=NC#N)NC3)ccc2NC(=O)c2nc(C#N)c[nH]2)CC1 CHEMBL1170997 IC50 2.5 nM
N#Cc1c[nH]c(C(=O)Nc2ccc(C3CCN(C(=O)Cc4ccccn4)CC3)cc2C2=CCCCC2)n1 CHEMBL2158295 IC50 2.5 nM
CC1(C)CC=C(c2cc(C(O)C(=O)O)ccc2NC(=O)c2ncc(C#N)[nH]2)CC1 CHEMBL3660781 IC50 2.5 nM
Nc1nccc(COc2ccc3nc(NC4CCCCC4)sc3c2)c1Cl CHEMBL4788945 Kd 2.5 nM
CN(Cc1cccnc1)c1ncnc2[nH]c(-c3ccc(CO)cc3)cc12 CHEMBL5426924 IC50 2.5 nM
CCN(CC)CCCNC(=O)c1cnc(N)c2c(-c3ccc(NC(=O)Nc4cccc(C)c4)cc3)csc12 CHEMBL1999414 pKi 2.512 nM
CCOc1ccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(C)c5)cnc(N)c34)cc2)cc1 CHEMBL1974254 pKi 2.512 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(-c5cn[nH]c5)cnc(N)c34)cc2)c1 CHEMBL1969102 pKi 2.512 nM
Cc1cccc(NC(=O)Nc2ccc(-c3cccc4[nH]ncc34)cc2)c1 CHEMBL375284 pKi 2.512 nM
CCN(CC)CCCNC(=O)c1cnc(N)c2c(-c3ccc(NC(=O)Nc4cccc(F)c4)cc3)csc12 CHEMBL1996649 pKi 2.512 nM
CCN(CC)CCNC(=O)c1c(C)[nH]c(C=C2C(=O)Nc3ccc(F)cc32)c1C CHEMBL1990885 pKi 2.512 nM
Cn1nc(N)c2c(-c3ccc(NC(=O)Nc4cccc(C(F)(F)F)c4)cc3)ccnc21 CHEMBL1985888 pKi 2.512 nM
CS(=O)(=O)CC(=O)N1CCC(c2ccc(NC(=O)c3nc(C#N)c[nH]3)c(C3=CCCCC3)c2)CC1 CHEMBL2158290 IC50 2.6 nM
CC1(C)CC=C(c2cc(CCS(=O)(=O)NN)ccc2NC(=O)c2nc(C#N)c[nH]2)CC1 CHEMBL3086178 IC50 2.6 nM
CNS(=O)(=O)CCc1ccc(NC(=O)c2nc(C#N)c[nH]2)c(C2=CCC(C)(C)CC2)c1 CHEMBL3660768 IC50 2.6 nM
COc1cc(NC(=O)c2ccc(C)c(C#Cc3cc(-c4cnn(C)c4)cnc3N)c2)cc(OC)c1 CHEMBL4553298 IC50 2.6 nM
COc1cc(OCc2ccnc(Nc3cnoc3)n2)cc2sc(N[C@H]3CCCC[C@@H]3O)nc12 CHEMBL4779197 IC50 2.6 nM
COC(C)(C)C(=O)NC(=O)Nc1ccc(Oc2ccnc(-c3cc(C)no3)c2)c(C)n1 CHEMBL5170451 IC50 2.6 nM
CN(CC1CCCO1)c1ncnc2[nH]c(-c3ccc(CO)cc3)nc12 CHEMBL5406229 IC50 2.6 nM
N#Cc1c[nH]c(C(=O)Nc2ccc(C3CCN(C(=O)c4cccnc4)CC3)cc2C2=CCCCC2)n1 CHEMBL2158231 IC50 2.7 nM
N#Cc1c[nH]c(C(=O)Nc2ccc(CCC(N)=O)cc2C2=CCCCC2)n1 CHEMBL3085980 IC50 2.7 nM
CCN(CC)CCC(=O)Nc1c(C)[nH]c(/C=C2\C(=O)Nc3cc(NC(=O)Nc4cc(C(C)(C)C)on4)ccc32)c1C CHEMBL5087520 IC50 2.7 nM
COc1cccc(CN(C)c2ncnc3[nH]c(-c4ccc(CO)cc4)nc23)c1 CHEMBL5399857 IC50 2.7 nM
CN(Cc1ccccc1)c1ncnc2[nH]c(-c3ccccc3)nc12 CHEMBL5410996 IC50 2.7 nM
Cc1cccc(CN(C)c2ncnc3[nH]c(-c4ccc(F)cc4)cc23)c1 CHEMBL5420485 IC50 2.7 nM
CN(C)C(=O)c1ccc(NC(=O)c2nc(C#N)c[nH]2)c(C2=CCC(C)(C)CC2)c1 CHEMBL3086163 IC50 2.8 nM
Cc1nc(NC(=O)NC(=O)C2(C)CCOCC2)ccc1Oc1ccnc(-c2cnn(C)c2)c1 CHEMBL5197168 IC50 2.8 nM
CN(Cc1ccccc1)c1ncnc2[nH]c(-c3ccc(O)cc3)cc12 CHEMBL5436096 IC50 2.8 nM
CN(Cc1ccccc1)c1ncnc2[nH]c(-c3cccc(O)c3)cc12 CHEMBL5417945 IC50 2.8 nM
CN(c1ncnc2[nH]c(-c3ccc(CO)cc3)cc12)[C@H](CO)c1ccccc1 CHEMBL5406951 IC50 2.8 nM
N#Cc1c[nH]c(C(=O)Nc2ccc(C3CNS(=O)(=O)NC3)cc2C2=CCCCC2)n1 CHEMBL1171606 IC50 2.9 nM
CN(C)S(=O)(=O)CCc1ccc(NC(=O)c2nc(C#N)c[nH]2)c(C2=CCC(C)(C)CC2)c1 CHEMBL3660766 IC50 2.9 nM
CN(C)CCNC(=O)Cc1ccc(NC(=O)c2nc(C#N)c[nH]2)c(C2=CCC(C)(C)CC2)c1 CHEMBL3660787 IC50 2.9 nM
CN(C)CCNC(=O)Cc1ccc(NC(=O)c2nc(C#N)c[nH]2)c(C2=CCC(C)(C)CC2)c1 CHEMBL4288418 IC50 2.9 nM
Cn1cc(-c2cc(Oc3ccc(NC(=O)NC(=O)Cc4ccc(F)cc4)nc3)ccn2)cn1 CHEMBL5176985 IC50 2.9 nM
CN(Cc1cccs1)c1ncnc2[nH]c(-c3ccc(CO)cc3)nc12 CHEMBL5397493 IC50 2.9 nM
Cc1ccc(F)c(NC(=O)Nc2ccc(-c3cccc4[nH]nc(N)c34)cc2)c1 CHEMBL223360 IC50 3.0 nM
N#Cc1ccc(C(=O)Nc2ccc(-n3ccnc3)cc2N2CCCCC2)o1 CHEMBL253027 IC50 3.0 nM
Nc1n[nH]c2nccc(-c3ccc(NC(=O)Nc4cccc(C(F)(F)F)c4)cc3)c12 CHEMBL255955 IC50 3.0 nM
CN(C)CCc1ccc(Nc2ncc3c(=O)c(C(N)=O)cn(-c4ccc5c(c4)CCC5)c3n2)cc1 CHEMBL256459 IC50 3.0 nM
Cc1cccc(C)c1/C=C/n1cnc2c(Nc3ccc(P(C)(C)=O)cc3)ncnc21 CHEMBL488840 IC50 3.0 nM
Cc1cc(C)cc(C(=O)Nc2ccc(Cl)c(C(=O)Nc3cncs3)c2)c1 CHEMBL461573 IC50 3.0 nM
O=C(Nc1ccc(Cl)c(C(=O)Nc2cncs2)c1)c1cccc(C(F)(F)F)c1 CHEMBL517437 IC50 3.0 nM
O=C(Nc1ccc(Cl)c(C(=O)Nc2cccnc2)c1)c1ccc(Cl)c(Cl)c1 CHEMBL461365 IC50 3.0 nM
O=C(Nc1ccc(Cl)c(C(=O)Nc2cccnc2)c1)c1cc(Cl)cc(Cl)c1 CHEMBL459674 IC50 3.0 nM
COc1cc2c(Nc3cccc(Cl)c3Cl)c(C(N)=O)cnc2cc1NCCN(C)C CHEMBL521262 IC50 3.0 nM
CCOc1cc2ncc(C(N)=O)c(Nc3cccc(Cl)c3Cl)c2cc1NCCN(C)C CHEMBL480814 IC50 3.0 nM
COc1cc2ncc(C(N)=O)c(Nc3ccc(Cl)cc3Cl)c2cc1N1CCN(C)CC1 CHEMBL481223 IC50 3.0 nM
CN1CCN(c2cc3c(Nc4cccc(Cl)c4Cl)c(C(N)=O)cnc3cc2F)CC1 CHEMBL481401 IC50 3.0 nM
CCn1cc(NC(=O)Cc2ccc(Oc3ccnc4cc(OC)c(OC)cc34)cc2OC)cn1 CHEMBL2023117 IC50 3.0 nM
CCN1CCC(Oc2ccnc(C(=O)Nc3ccc(NC(=O)Nc4cc(C(C)(C)C)on4)cc3)c2)CC1 CHEMBL2203432 Kd 3.0 nM
COc1cc(Cn2cnc3cc(-c4cnn(C5CCNCC5)c4)cnc32)ccc1OCc1ccc(C)nc1 CHEMBL3673463 IC50 3.0 nM
COc1ccc(COc2ccc(Cn3cnc4cc(-n5cc(C6CCCNC6)nn5)cnc43)cc2OC)cn1 CHEMBL3673468 IC50 3.0 nM
COc1ccc(COc2ccc(Cn3c(N)nc4cc(-c5cnn(C)c5)cnc43)cc2OC)cn1 CHEMBL3673476 IC50 3.0 nM
COc1cc(Cn2c(N)nc3cc(-c4cnn(C)c4)cnc32)ccc1OCc1ccc(C2CC2)nc1 CHEMBL3673479 IC50 3.0 nM
Cn1cc(-c2cc(Oc3ccc(NC(=O)N4CCN(C5CCCCC5)C4=O)nc3)ccn2)cn1 CHEMBL3893595 IC50 3.0 nM
CCC(=O)N1CC[C@H](N2C(=O)N(c3cc(OC)ccc3Cl)Cc3cnc(Nc4ccc(N5CCN(C6COC6)CC5)c(C)c4)nc32)C1 CHEMBL4066141 IC50 3.0 nM
Cc1ccc(C(=O)Nc2ccc(C(F)(F)F)cc2)cc1C#Cc1cc(-c2cnn(C)c2)cnc1N CHEMBL4589346 IC50 3.0 nM
Cc1[nH]c(/C=C2\C(=O)Nc3cc(NC(=O)Nc4cc(C(C)(C)C)on4)ccc32)c(C)c1NC(=O)CCNC1CCCC1 CHEMBL5083932 IC50 3.0 nM
Cc1nc(-c2cnc(NC(C)C)n(C)c2=O)ccc1Oc1ccnc(-c2cnn(C)c2)c1 CHEMBL5095202 IC50 3.0 nM
Cc1nc(NC(=O)NC(=O)C2CCC2)ccc1Oc1ccnc(-c2cnn(C)c2)c1 CHEMBL5181597 IC50 3.0 nM
Cc1cccc(CN(C)c2ncnc3[nH]c(-c4ccc(C(F)F)cc4)cc23)c1 CHEMBL5397426 IC50 3.0 nM
CCN1CCC(c2ccc(C(=O)Nc3ccc(NC(=O)Nc4cc(C(C)(C)C)on4)cc3)nc2)CC1 CHEMBL2203426 Kd 3.1 nM
Cc1[nH]c(/C=C2\C(=O)Nc3cc(NC(=O)Nc4cc(C(C)(C)C)on4)ccc32)c(C)c1NC(=O)C1CCNCC1 CHEMBL5081276 IC50 3.1 nM
CCCn1cc(-c2cnc(N)c3c(-c4ccc(NC(=O)Nc5cccc(F)c5)cc4)csc23)cn1 CHEMBL1993941 pKi 3.162 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4nc(N)nc(N)c34)cc2)c1 CHEMBL1973145 pKi 3.162 nM
Cc1ccc(F)c(NC(=O)Nc2ccc(-c3cccc4[nH]nc(N)c34)c(F)c2)c1 CHEMBL1988778 pKi 3.162 nM
CC(O)Cn1cc(-c2cnc(N)c3c(-c4ccc(NC(=O)Nc5cccc(F)c5)cc4)csc23)cn1 CHEMBL2002165 pKi 3.162 nM
Nc1n[nH]c2cccc(-c3ccc(NC(=O)Nc4cccc(C(F)(F)F)c4)c(F)c3)c12 CHEMBL1980904 pKi 3.162 nM
CN1CCN(Cc2ccc3c(c2)Cc2c(-c4csc(C#CCOCC5CC5)c4)n[nH]c2-3)CC1 CHEMBL2002446 pKi 3.162 nM
CNC(=O)c1cnc(N)c2c(-c3ccc(NC(=O)Nc4cc(C)ccc4F)cc3)csc12 CHEMBL2005631 pKi 3.162 nM
C[C@@H](O)Cn1cc(-c2cnc(N)c3c(-c4ccc(NC(=O)Nc5cccc(F)c5)cc4)csc23)cn1 CHEMBL2022856 pKi 3.162 nM
CCNC(=O)c1cn(-c2ccc3c(c2)CCC3)c2nc(Nc3ccc(CCN4CCN(C)CC4)cc3)ncc2c1=O CHEMBL507619 IC50 3.2 nM
CN(C)CC(=O)N1CCC(c2ccc(NC(=O)c3nc(C#N)c[nH]3)c(C3=CCCCC3)c2)CC1 CHEMBL1908395 Kd 3.2 nM
N#Cc1cnc(C(=O)Nc2ccc(CN3CCOCC3)cc2C2=CCCCC2)[nH]1 CHEMBL3085983 IC50 3.2 nM
N#Cc1c[nH]c(C(=O)Nc2ccc(CCS(=O)(=O)N3CCOCC3)cc2C2=CCCCC2)n1 CHEMBL3086179 IC50 3.2 nM
CC1(C)CC=C(c2nc(C3CC(C)(C)OC(C)(C)C3)ccc2NC(=O)c2nc(C#N)c[nH]2)CC1 CHEMBL3674570 IC50 3.2 nM
Cc1nc(NC(=O)NC(=O)CC2CCCCC2)ccc1Oc1ccnc(-c2cnn(C)c2)c1 CHEMBL5176270 IC50 3.2 nM
N#Cc1c[nH]c(C(=O)Nc2ccc(C3CCN(C(N)=O)CC3)cc2C2=CCCCC2)n1 CHEMBL2158303 IC50 3.3 nM
CC1(C)CC=C(c2cc(C(C)(C)N3CCS(=O)(=O)CC3)ccc2NC(=O)c2nc(C#N)c[nH]2)CC1 CHEMBL3085829 IC50 3.3 nM
Cn1cc(-c2cnc3c(-c4csc(C(=O)N[C@@H]5CCCC[C@@H]5N)c4)cnn3c2)cn1 CHEMBL4568087 IC50 3.3 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(NC(=O)c3ccc(OC4CCN(CC(F)(F)F)CC4)cn3)cc2)no1 CHEMBL2203436 Kd 3.4 nM
CCC(=O)N1CC[C@H](N2C(=O)N(c3cc(OC)ccc3F)Cc3cnc(Nc4ccc(N5CCN(C6COC6)CC5)c(C)c4)nc32)C1 CHEMBL4072688 IC50 3.4 nM
CC1(c2ccc(NC(=O)c3ncc(C#N)[nH]3)c(C3=CCCCC3)c2)OCCO1 CHEMBL3643700 IC50 3.4 nM
Cc1[nH]c(/C=C2\C(=O)Nc3cc(NC(=O)Nc4cc(C(C)(C)C)on4)ccc32)c(C)c1NC(=O)[C@H]1CCCN1 CHEMBL5090579 IC50 3.4 nM
CCN(CC)CC(=O)Nc1c(C)[nH]c(/C=C2\C(=O)Nc3cc(NC(=O)Nc4cc(C(C)(C)C)on4)ccc32)c1C CHEMBL5086869 IC50 3.4 nM
Cc1[nH]c(/C=C2\C(=O)Nc3cc(NC(=O)Nc4cc(C(C)(C)C)on4)ccc32)c(C)c1NC(=O)CCNC(C)(C)C CHEMBL5075758 IC50 3.4 nM
CC1(C)CC=C(c2cc(C(C)(C)CN3CCS(=O)(=O)CC3)ccc2NC(=O)c2nc(C#N)c[nH]2)CC1 CHEMBL3085972 IC50 3.5 nM
COc1cc(NC(=O)c2ccc(C)c(C#Cc3cc(C(N)=O)cnc3N)c2)cc(OC)c1 CHEMBL4459031 IC50 3.5 nM
Cc1nc(NC(=O)NC(=O)C2(C)CC2)ccc1Oc1ccnc(-c2cnn(C)c2)c1 CHEMBL5170039 IC50 3.5 nM
CN(Cc1cccc(F)c1)c1ncnc2[nH]c(-c3ccc(CO)cc3)nc12 CHEMBL5394928 IC50 3.5 nM
Cc1[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c(C)c1C(=O)NC[C@H](O)CN1CCOCC1 CHEMBL1721885 Kd 3.6 nM
N#Cc1c[nH]c(C(=O)Nc2ccc(C(N)=O)cc2C2=CCCCC2)n1 CHEMBL3086325 IC50 3.6 nM
Cc1nc(-c2cnc(NC3CC3)[nH]c2=O)ccc1Oc1ccnc(-c2cnn(C)c2)c1 CHEMBL5200885 IC50 3.6 nM
CC(C)(O)Cc1ccc(NC(=O)c2nc(C#N)c[nH]2)c(C2=CCCCC2)c1 CHEMBL3086171 IC50 3.7 nM
CC1(C)CC=C(c2cc(-c3nnn[nH]3)ccc2NC(=O)c2nc(C#N)c[nH]2)CC1 CHEMBL3086170 IC50 3.7 nM
Cc1cc(NC(=O)NC(=O)Cc2ccc(F)cc2)ncc1Oc1ccnc(-c2cnn(C)c2)c1 CHEMBL5186979 IC50 3.7 nM
CN(Cc1ccccc1)c1ncnc2[nH]c(-c3cccc(OCC4OCCO4)c3)cc12 CHEMBL5438430 IC50 3.7 nM
CN(Cc1ccccc1)c1ncnc2[nH]c(-c3ccc(CO)c(F)c3)cc12 CHEMBL5418474 IC50 3.7 nM
CCN1CCN(Cc2ccc(NC(=O)Nc3ccc(C4=Nc5cscc5NC(=O)C4)cc3)cc2C(F)(F)F)CC1 CHEMBL4228601 IC50 3.73 nM
N#Cc1c[nH]c(C(=O)Nc2ccc(C3CCN(C(=O)CN4CCOCC4)CC3)cc2C2=CCCCC2)n1 CHEMBL2158299 IC50 3.8 nM
Cc1[nH]c(/C=C2\C(=O)Nc3cc(NC(=O)Nc4cc(C(C)(C)C)on4)ccc32)c(C)c1NC(=O)CNC1CCCC1 CHEMBL5078237 IC50 3.8 nM
Cc1nc(NC(=O)NC(=O)C2CCCC2)ccc1Oc1ccnc(-c2cnn(C)c2)c1 CHEMBL5174778 IC50 3.8 nM
COc1cc(OC)c(Cl)c(-c2ccc3c(NC(=O)c4ccc(N5CCNC(C)(C)C5)cc4)n[nH]c3n2)c1Cl CHEMBL5269917 IC50 3.8 nM
CN(Cc1cccnc1)c1ncnc2[nH]c(-c3ccc(CO)cc3)nc12 CHEMBL5428593 IC50 3.8 nM
N#Cc1cnc(C(=O)Nc2ccc(/C=C/C(=O)O)cc2C2=CCCCC2)[nH]1 CHEMBL3889904 IC50 3.9 nM
C=C(CN1CCOCC1)c1ccc(NC(=O)c2ncc(C#N)[nH]2)c(C2=CCCCC2)c1 CHEMBL3660790 IC50 3.9 nM
C=C(CN1CCOCC1)c1ccc(NC(=O)c2nc(C#N)c[nH]2)c(C2=CCCCC2)c1 CHEMBL4285243 IC50 3.9 nM
CC1(c2ccc(NC(=O)c3ncc(C#N)[nH]3)c(C3=CCCCC3)c2)OCCCO1 CHEMBL3643701 IC50 3.9 nM
Cc1ccc(C(=O)Nc2ccc(Cl)c(C(F)(F)F)c2)cc1NC(=O)C1(c2ncnc3[nH]cnc23)CC1 CHEMBL4466555 IC50 3.9 nM
Cc1nc(NC(=O)NC(=O)C2CCCCC2)ccc1Oc1ccnc(-c2cnn(C)c2)c1 CHEMBL5177368 IC50 3.9 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(CC(C)O)c5)cnc(N)c34)cc2)c1 CHEMBL1989708 pKi 3.981 nM
CNC(=O)C=Cc1cnc(N)c2c(-c3cc(F)c4[nH]c(C)cc4c3)csc12 CHEMBL2006778 pKi 3.981 nM
COc1ccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(CC(O)CO)c5)cnc(N)c34)cc2)cc1 CHEMBL1965170 pKi 3.981 nM
Cc1cccc(NC(=O)Nc2ccc(-c3cccc4[nH]nc(N)c34)cc2)c1 CHEMBL220057 pKi 3.981 nM
Cn1nc(N)c2c(-c3ccc(NC(=O)Nc4ccc(F)c(C(F)(F)F)c4)cc3)ccnc21 CHEMBL1966836 pKi 3.981 nM
CNC(=O)C=Cc1cnc(N)c2c(-c3ccc4sc(C)nc4c3)csc12 CHEMBL1968590 pKi 3.981 nM
Cc1cc(C)cc(NC(=O)Nc2ccc(-c3cccc4onc(N)c34)cc2)c1 CHEMBL409349 pKi 3.981 nM
NC(=O)c1cn(-c2ccc3c(c2)CCC3)c2nc(Nc3cccc(C(=O)N4CCCCC4)c3)ncc2c1=O CHEMBL402852 IC50 4.0 nM
Cc1cc(C)cc(C(=O)Nc2ccc(C)c(C(=O)Nc3cnc(C)s3)c2)c1 CHEMBL444671 IC50 4.0 nM
Cc1ncc(NC(=O)c2cc(NC(=O)c3cccc(Cl)c3)ccc2Cl)s1 CHEMBL462133 IC50 4.0 nM
Cc1ccc(NC(=O)c2ccc(CN3CCN(C)CC3)cc2)cc1-c1ccc2ccncc2c1 CHEMBL521887 IC50 4.0 nM
Cc1cccc(NC(=O)Nc2ccc(-c3cnc4c(-c5cnn(C)c5)ccn4c3N)cc2)c1 CHEMBL453057 IC50 4.0 nM
C[C@H](Nc1cncc(Cl)n1)c1cccc(NC(=O)c2cncc(Br)c2)c1 CHEMBL515867 IC50 4.0 nM
CCc1cc(NC(=O)Cc2ccc(Oc3ccnc4cc(OC)ccc34)cc2OC)no1 CHEMBL2023482 IC50 4.0 nM
COc1ccc(COc2ccc(Cn3c(N)nc4cc(-c5cncnc5)ccc43)cc2OC)cc1 CHEMBL3673437 IC50 4.0 nM
COc1ccc(COc2ccc(Cn3c(N)nc4cc(-c5cnn(CCN6CCOCC6)c5)ccc43)cc2OC)cc1 CHEMBL3673439 IC50 4.0 nM
CC(=O)c1ccc(Nc2nccc3c(NC(=O)c4csc5c(N)ncnc45)c(C)ccc23)cc1 CHEMBL3944137 IC50 4.0 nM
Cc1ccc(NC(=O)c2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1NC(=O)c1cccc(-c2cccnc2)c1 CHEMBL4059858 IC50 4.0 nM
Cn1ccc2cc(CC(=O)Nc3ccc(-n4c5c(c6ncnc(N)c64)CCC5)cc3)ccc21 CHEMBL4445355 IC50 4.0 nM
COc1cc(OCc2ccnc(NC(C)=O)c2)cc2sc(N[C@@H]3CCCC[C@H]3O)nc12 CHEMBL4754431 IC50 4.0 nM
COC(=O)c1ccc(-c2cc3c(N(C)Cc4cccc(C)c4)ncnc3[nH]2)cc1 CHEMBL5416772 IC50 4.0 nM
CCS(=O)(=O)N1CCN(c2ccc(Nc3ncc(C(N)=O)c(NC4CC4)n3)cc2)CC1 CHEMBL4116008 IC50 4.0 nM
CONC(=O)c1cn(C2CCCCC2)c2nc(Nc3ccc(CCN4CCCC4)cc3)ncc2c1=O CHEMBL490080 IC50 4.1 nM
COc1cc(OCc2ccnc(N)n2)cc2sc(N[C@H]3CCCC[C@@H]3O)nc12 CHEMBL4762843 Kd 4.1 nM
CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3cc(NC(=O)Nc4cc(C(C)(C)C)on4)ccc32)c1C CHEMBL5084385 IC50 4.1 nM
Cc1nc(NC(=O)NC(=O)C(C)(C)C)ccc1Oc1ccnc(-c2cnn(C)c2)c1 CHEMBL5195204 IC50 4.1 nM
O=C1Nc2ccc(F)cc2/C1=C1/Nc2ccccc2/C1=N\OCCN1CCNCC1 CHEMBL4791998 IC50 4.2 nM
COc1ccccc1CN(C)c1ncnc2[nH]c(-c3ccc(CO)cc3)nc12 CHEMBL5408316 IC50 4.2 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(NC(=O)c3ncccc3O)cc2)no1 CHEMBL1079545 Kd 4.4 nM
CC(=O)OCC(COC(C)=O)c1ccc(NC(=O)c2ncc(C#N)[nH]2)c(C2=CCCCC2)c1 CHEMBL3660759 IC50 4.4 nM
CCC(=O)N1CC[C@H](N2C(=O)N(c3cccc(OC)c3Cl)Cc3cnc(Nc4ccc(N5CCN(C)CC5)c(C)c4)nc32)C1 CHEMBL4063067 IC50 4.4 nM
CC(=O)OCC(COC(C)=O)c1ccc(NC(=O)c2nc(C#N)c[nH]2)c(C2=CCCCC2)c1 CHEMBL4289455 IC50 4.4 nM
COc1cc(C2CN(C(=O)c3cc(OCCN4CCN(C)CC4)ccn3)C2)ccc1OCc1ccc(C2CC2)cc1 CHEMBL4452717 IC50 4.4 nM
N#Cc1c[nH]c(C(=O)Nc2ccc(-c3ccncc3)cc2C2=CCCCC2)n1 CHEMBL1172346 IC50 4.5 nM
N#Cc1c[nH]c(C(=O)Nc2ccc(-c3ccc(N)nc3)cc2C2=CCCCC2)n1 CHEMBL1172313 IC50 4.5 nM
CC1(C)CC=C(c2cc(CCS(=O)(=O)N3CCOCC3)ccc2NC(=O)c2ncc(C#N)[nH]2)CC1 CHEMBL3086314 IC50 4.5 nM
CCC(=O)N1CC[C@H](N2C(=O)N(c3cccc(OC)c3F)Cc3cnc(Nc4ccc(N5CCN(C)CC5)c(C)c4)nc32)C1 CHEMBL4078801 IC50 4.5 nM
CCC(=O)N1CC[C@H](N2C(=O)N(c3cccc(OC)c3)Cc3cnc(Nc4ccc(N5CCN(C)CC5)c(C)c4)nc32)C1 CHEMBL4105503 IC50 4.5 nM
CC1(C)CC=C(c2cc(CCO)ccc2NC(=O)c2nc(C#N)c[nH]2)CC1 CHEMBL3086174 IC50 4.6 nM
COc1ccc(Oc2nc(Nc3ccc(N4CCOCC4)cc3)ncc2/N=C/c2cc(OC)cc(OC)c2)cc1 CHEMBL4165412 IC50 4.6 nM
N#Cc1cnc(C(=O)Nc2ccc(CN3CCOCC3)cc2C2=CCCCC2)[nH]1 CHEMBL4293513 IC50 4.6 nM
Cc1[nH]c(/C=C2\C(=O)Nc3cc(NC(=O)Nc4cc(C(C)(C)C)on4)ccc32)c(C)c1NC(=O)CN1CCCCC1 CHEMBL5083454 IC50 4.6 nM
CN(CC1CCOC1)c1ncnc2[nH]c(-c3ccc(CO)cc3)nc12 CHEMBL5401076 IC50 4.6 nM
CC(C)(NS(C)(=O)=O)c1ccc(NC(=O)c2ncc(C#N)[nH]2)c(C2=CCCCC2)c1 CHEMBL3660753 IC50 4.7 nM
CCC(=O)N1CC[C@H](N2C(=O)N(c3cc(OC)ccc3F)Cc3cnc(Nc4ccc(N5CCC(N(C)C)CC5)c(C)c4)nc32)C1 CHEMBL4076405 IC50 4.7 nM
Cc1nc(-c2cnc(NC3CCCC3)[nH]c2=O)ccc1Oc1ccnc(-c2cnn(C)c2)c1 CHEMBL5192630 IC50 4.7 nM
COc1cc2c(N3CCN(C(=O)Nc4ccc(OC(C)C)cc4)CC3)ncnc2cc1OCCCN1CCCCC1 CHEMBL124660 Kd 4.9 nM
CN1CCN(Cc2ccc(C(=O)Nc3ccc(NC(=O)Nc4cc(C(C)(C)C)on4)cc3)nc2)CC1 CHEMBL2203428 Kd 4.9 nM
CCC(=O)N1CC[C@H](N2C(=O)N(c3cc(OC)ccc3F)Cc3cnc(Nc4ccc(N5CCCN(C)CC5)c(C)c4)nc32)C1 CHEMBL4083224 IC50 4.9 nM
Cc1cccc(CN(C)c2ncnc3[nH]c(-c4ccc(C(F)(F)F)cc4)cc23)c1 CHEMBL5417719 IC50 4.9 nM
NC(=O)c1cn(-c2ccc3c(c2)CCC3)c2nc(Nc3ccc(N4CCNCC4)cc3)ncc2c1=O CHEMBL271461 IC50 5.0 nM
CC1CCN(c2cc(C#CCN3CCOCC3)ccc2NC(=O)c2ccc(C#N)o2)CC1 CHEMBL402908 IC50 5.0 nM
O=C(Nc1ccc(Cl)c(C(=O)Nc2cncs2)c1)c1cccc(Cl)c1 CHEMBL461572 IC50 5.0 nM
Cc1ccc(C(=O)Nc2ccc(Cl)c(C(=O)Nc3cccnc3)c2)cc1C CHEMBL459471 IC50 5.0 nM
CONC(=O)c1cn(C2CCCCC2)c2nc(Nc3ccc(C4CCN(C)CC4)cc3)ncc2c1=O CHEMBL489883 IC50 5.0 nM
Nc1ncc(NC(=O)c2cc(NC(=O)c3cccc(C(F)(F)F)c3)ccc2Cl)cc1Cl CHEMBL475817 IC50 5.0 nM
Cc1cncc(C(=O)Nc2cccc([C@H](C)Nc3cncc(Cl)n3)c2)c1 CHEMBL472860 IC50 5.0 nM
Cc1cncc(C(=O)Nc2cccc([C@H](C)Nc3cncc(Br)c3)c2)c1 CHEMBL514619 IC50 5.0 nM
CCn1cc(NC(=O)Cc2ccc(Oc3ccnc4cc(OC)ccc34)cc2OC)cn1 CHEMBL2023118 IC50 5.0 nM
CCc1cc(NC(=O)Cc2ccc(Oc3ccnc4cc(OC)ccc34)cc2OC)n[nH]1 CHEMBL2023486 IC50 5.0 nM
COc1ccc(COc2ccc(Cn3cnc4cc(N5CCC(C(C)(C)N)CC5)cnc43)cc2OC)cn1 CHEMBL3673455 IC50 5.0 nM
COc1cc(Cn2c(N)nc3cc(-c4cnn(C)c4)cnc32)ccc1OCc1ccc(C(F)(F)F)nc1 CHEMBL3673477 IC50 5.0 nM
COc1cc(Cn2c(N)nc3cc(-c4cnn(C)c4)cnc32)ccc1OCc1ccc(C(F)(F)F)cc1 CHEMBL3673478 IC50 5.0 nM
COc1cc(Cn2c(N)nc3cc(-c4cnn(C)c4)cnc32)ccc1OCc1csc(C)n1 CHEMBL3673480 IC50 5.0 nM
COc1ccc(COc2ccc(Cn3c(N)nc4cc(-c5ccn(C)n5)cnc43)cc2OC)cn1 CHEMBL3673483 IC50 5.0 nM
COc1ccc(COc2ccc(Cn3c(N)nc4cc(-c5c(C)nn(C)c5C)cnc43)cc2OC)cn1 CHEMBL3673485 IC50 5.0 nM
COc1ccc(COc2ccc(Cn3c(N)nc4cc(-c5ccccn5)cnc43)cc2OC)cn1 CHEMBL3673488 IC50 5.0 nM
COc1cc(Cn2c(N)nc3cc(-c4cnn(C)c4)cnc32)ccc1OCc1ccc(C(C)C)nc1 CHEMBL3678285 IC50 5.0 nM
CNC(=O)c1cc(Oc2ccc(NC(=O)N3CCN(C(C)(C)C)C3=O)nc2)ccn1 CHEMBL3957739 IC50 5.0 nM
CCC(=O)N1CC[C@H](N2C(=O)N(c3ccccc3Cl)Cc3cnc(Nc4ccc(N5CCN(C)CC5)c(C)c4)nc32)C1 CHEMBL4098507 IC50 5.0 nM
COC(=O)c1ccc2c(C(Nc3ccc(N(C)C(=O)CN4CCN(C)CC4)cc3)c3ccccc3)c(O)[nH]c2c1 CHEMBL5201102 IC50 5.0 nM
COc1ccc(-c2ccc(NC(=O)Nc3ccc(OC(F)(F)F)cc3)cc2)c2c(N)noc12 CHEMBL1973178 pKi 5.012 nM
Cc1ccc(F)c(NC(=O)Nc2ccc(-c3coc4c(C#CCN5CCOCC5)cnc(N)c34)cc2)c1 CHEMBL1983640 pKi 5.012 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(C#CCN)cnc(N)c34)cc2)c1 CHEMBL1965988 pKi 5.012 nM
Nc1n[nH]c2cccc(-c3ccc(NC(=O)Nc4cc(CO)ccc4F)cc3)c12 CHEMBL1985311 pKi 5.012 nM
CNCC#Cc1cnc(N)c2c(-c3ccc(NC(=O)Nc4cccc(C)c4)cc3)csc12 CHEMBL1964441 pKi 5.012 nM
COc1ccc(-n2ccc3cnc(Nc4cc(OC)c(OC)c(OC)c4)nc32)cc1 CHEMBL1975927 pKi 5.012 nM
CC(C)(C(N)=O)n1cc(-c2cnc(N)c3c(-c4ccc(NC(=O)Nc5cccc(F)c5)cc4)csc23)cn1 CHEMBL1967720 pKi 5.012 nM
CCC(=O)N1CC[C@H](N2C(=O)N(c3ccccc3OC)Cc3cnc(Nc4ccc(N5CCN(C)CC5)c(C)c4)nc32)C1 CHEMBL4070640 IC50 5.1 nM
Cn1ccc2c(Oc3ccc(NC(=O)Cc4ccc(C(F)(F)F)c(F)c4)cc3)ncnc21 CHEMBL5394677 IC50 5.14 nM
CONC(=O)c1cn(-c2ccc3c(c2)CCC3)c2nc(Nc3ccc(OC)nc3)ncc2c1=O CHEMBL491078 IC50 5.2 nM
CCC(=O)N1CC[C@H](N2C(=O)N(c3ccccc3F)Cc3cnc(Nc4ccc(N5CCN(C)CC5)c(C)c4)nc32)C1 CHEMBL4060198 IC50 5.2 nM
Cc1nc(NC(=O)NC(=O)C(C)C)ccc1Oc1ccnc(-c2cnn(C)c2)c1 CHEMBL5194023 IC50 5.2 nM
COc1cccc(-c2cc3c(N(C)Cc4ccccc4)ncnc3[nH]2)c1 CHEMBL5411522 IC50 5.2 nM
CC(=O)N1CC[C@H](N2C(=O)N(c3ccccc3Cl)Cc3cnc(Nc4ccc(N5CCN(C)CC5)c(C)c4)nc32)C1 CHEMBL4074601 IC50 5.5 nM
CNC(=O)c1cc(Oc2ccc3nc(N[C@@H]4CCCC[C@@H]4O)sc3c2)ccn1 CHEMBL4225509 IC50 5.5 nM
COC(=O)c1cnc(N)c(C#Cc2cc(C(=O)Nc3cc(OC)cc(OC)c3)ccc2C)c1 CHEMBL4573871 IC50 5.5 nM
Cn1cc(-c2ccc(CNc3cc(-c4cnc5cc(OCCCN6CCCC6)ccn45)ncn3)cc2)cn1 CHEMBL5314917 IC50 5.5 nM
CC1(C)CNc2cc(NC(=O)c3cccnc3NCc3ccncc3)ccc21 CHEMBL572881 Kd 5.6 nM
N#Cc1c[nH]c(C(=O)Nc2ccc(CCS(=O)(=O)NN)cc2C2=CCCCC2)n1 CHEMBL3086177 IC50 5.6 nM
CNS(=O)(=O)CCc1ccc(NC(=O)c2nc(C#N)c[nH]2)c(C2=CCCCC2)c1 CHEMBL3660767 IC50 5.6 nM
CCC(=O)N1CC[C@H](N2C(=O)N(c3ccccc3C)Cc3cnc(Nc4ccc(N5CCN(C)CC5)c(C)c4)nc32)C1 CHEMBL4089951 IC50 5.6 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(C[C@H](C)O)c5)cnc(N)c34)cc2)c1 CHEMBL3646210 IC50 5.62 nM
CC(=O)N1CCN(CC(C)(C)c2ccc(NC(=O)c3nc(C#N)c[nH]3)c(C3=CCC(C)(C)CC3)c2)CC1 CHEMBL3085971 IC50 5.7 nM
COc1cc(OCc2ccnc(Nc3cn(C)nn3)n2)cc2sc(N[C@H]3CCCC[C@@H]3O)nc12 CHEMBL4763289 IC50 5.7 nM
COc1ccc(CN(C)c2ncnc3[nH]c(-c4ccc(CO)cc4)nc23)cc1OC CHEMBL5414671 IC50 5.7 nM
CCN1CCN(Cc2ccc(NC(=O)Nc3ccc(Oc4cc(NC)ncn4)cc3)cc2C(F)(F)F)CC1 CHEMBL574738 Kd 5.8 nM
CCC(=O)N1CC[C@H](N2C(=O)N(c3cc(OC)ccc3F)Cc3cnc(Nc4ccc(N5CCN(C)CC5)c(OC)c4)nc32)C1 CHEMBL4065984 IC50 5.8 nM
CCC(=O)N1CC[C@H](N2C(=O)N(c3ccc(OC)cc3)Cc3cnc(Nc4ccc(N5CCN(C)CC5)c(C)c4)nc32)C1 CHEMBL4081252 IC50 5.8 nM
N#Cc1c[nH]c(C(=O)Nc2ccc(CCC(=O)O)cc2C2=CCCCC2)n1 CHEMBL3085979 IC50 5.9 nM
Cc1ccc(C(=O)Nc2ccc(Cl)cc2Cl)cc1C#Cc1cc(-c2cnn(C)c2)cnc1N CHEMBL4467948 IC50 5.9 nM
Cc1cc(C)cc(C(=O)Nc2ccc(Cl)c(C(=O)Nc3cnc(C)s3)c2)c1 CHEMBL462128 IC50 6.0 nM
COc1cc2ncc(C(N)=O)c(Nc3cccc(Cl)c3Cl)c2cc1OC CHEMBL519779 IC50 6.0 nM
CCOc1cc2ncc(C(N)=O)c(Nc3cccc(Cl)c3Cl)c2cc1NCCN1CCCCC1 CHEMBL480815 IC50 6.0 nM
COc1cc2ncc(C(N)=O)c(Nc3ccc(F)cc3F)c2cc1N1CCN(C)CC1 CHEMBL480445 IC50 6.0 nM
CCOc1cc2ncc(C(N)=O)c(Nc3ccc(F)cc3F)c2cc1N1CCN(C)CC1 CHEMBL481806 IC50 6.0 nM
COc1ccc(COc2ccc(Cn3cnc4cc(-n5cc(C6CCCNC6)nn5)ccc43)cc2OC)cn1 CHEMBL3673443 IC50 6.0 nM
COc1ccc(COc2ccc(Cn3c(N)nc4cc(-c5cccnc5)cnc43)cc2OC)cn1 CHEMBL3673487 IC50 6.0 nM
Cn1cc(-c2cc(Oc3ccc(NC(=O)N4CCN(C5CCOCC5)C4=O)nc3)ccn2)cn1 CHEMBL3891316 IC50 6.0 nM
Nc1ncnc2c(C(=O)Nc3cccc4c3c(Br)nn4Cc3cccnc3)csc12 CHEMBL4455896 IC50 6.0 nM
COc1cc(-n2c3c(c4ncnc(N)c42)COC3)ccc1NC(=O)Cc1ccc(OC(F)(F)F)cc1 CHEMBL4441235 IC50 6.0 nM
CCOc1cc2ccc(C(N)=O)c(Nc3ccc(F)cc3F)c2cc1N1CCN([11CH3])CC1 CHEMBL5180946 IC50 6.0 nM
CC(=O)NC(C)(C)c1ccc(NC(=O)c2nc(C#N)c[nH]2)c(C2=CCCCC2)c1 CHEMBL3660754 IC50 6.1 nM
COC(C)(C)C(=O)NC(=O)Nc1ccc(Oc2ccnc(-c3cnn(C)c3)c2)c(C)n1 CHEMBL5170609 IC50 6.1 nM
CCC(=O)N1CC[C@H](N2C(=O)N(c3cc(OC)ccc3F)Cc3cnc(Nc4ccc(N5CCC6(CCN(C)CC6)CC5)c(C)c4)nc32)C1 CHEMBL4104717 IC50 6.2 nM
CCN(Cc1ccccc1)c1ncnc2[nH]c(-c3ccc(CO)cc3)cc12 CHEMBL5418732 IC50 6.2 nM
CN1CCN(c2ccc(NC(=O)c3ccc(C#N)o3)c(N3CCCC(F)C3)c2)CC1 CHEMBL252633 IC50 6.3 nM
Cc1cccc(NC(=O)Nc2ccc(-c3ccc4nccnc4c3N)cc2)c1 CHEMBL507936 pKi 6.31 nM
CCN1CCN(c2ccc(Nc3ncc(Cl)c(Nc4ccc5[nH]ncc5c4)n3)cc2)CC1 CHEMBL1967998 pKi 6.31 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4ccnc(N)c34)cc2)c1 CHEMBL394619 pKi 6.31 nM
Nc1n[nH]c2cccc(-c3ccc(NC(=O)Nc4ccccc4)cc3)c12 CHEMBL219722 pKi 6.31 nM
Cn1cc(-c2cnn3c(N)c(-c4ccc(NC(=O)Nc5cccc(C(F)(F)F)c5)cc4)cnc23)cn1 CHEMBL1988717 pKi 6.31 nM
COc1ccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(CC(C)(C)O)c5)cnc(N)c34)cc2)cc1 CHEMBL2004290 pKi 6.31 nM
COC(=O)c1cccc(-c2cc3c(N(C)Cc4cccc(C)c4)ncnc3[nH]2)c1 CHEMBL5415647 IC50 6.4 nM
CCC(=O)N1CC[C@H](N2C(=O)N(c3cc(OC)ccc3F)Cc3cnc(Nc4ccc(N5CC6(CCN(C)CC6)C5)c(C)c4)nc32)C1 CHEMBL4078973 IC50 6.5 nM
COc1cc(NC(=O)c2ccc(Cl)c(C#Cc3cc(-c4cnn(C)c4)cnc3N)c2)cc(OC)c1 CHEMBL4565816 IC50 6.5 nM
Cc1ccc(C(=O)Nc2ccccc2)cc1C#Cc1cc(-c2cnn(C)c2)cnc1N CHEMBL4460375 IC50 6.5 nM
COC(C)(C)C(=O)NC(=O)Nc1ccc(Oc2ccnc(-c3ccnc(C)c3)c2)c(C)n1 CHEMBL5175832 IC50 6.5 nM
Cc1cc(Nc2ncc3c(n2)N([C@H]2CCN(C(=O)C(C)C)C2)C(=O)N(c2ccccc2Cl)C3)ccc1N1CCN(C)CC1 CHEMBL4095063 IC50 6.7 nM
COc1cc(OCc2ccnc(N)n2)cc2sc(N[C@@H]3CCCC[C@H]3O)nc12 CHEMBL4788832 Kd 6.7 nM
N#Cc1c[nH]c(C(=O)Nc2ccc(CCO)cc2C2=CCCCC2)n1 CHEMBL3086173 IC50 6.8 nM
CCC(=O)N1CC[C@H](N2C(=O)N(c3cc(OC)ccc3F)Cc3cnc(Nc4ccc(N5CCC6(CCN(C)C6)C5)c(C)c4)nc32)C1 CHEMBL4086821 IC50 6.8 nM
N#Cc1c[nH]c(C(=O)Nc2ccc(S(N)(=O)=O)cc2C2=CCCCC2)n1 CHEMBL3086161 IC50 6.9 nM
CC1CN(c2ccc(Nc3ncc4c(=O)c(C(N)=O)cn(-c5ccc6c(c5)CCC6)c4n3)cc2)CC(C)N1 CHEMBL255794 IC50 7.0 nM
Cc1ncc(NC(=O)c2cc(NC(=O)c3cc(F)cc(C(F)(F)F)c3)ccc2Cl)s1 CHEMBL459675 IC50 7.0 nM
Cc1ncc(NC(=O)c2cc(NC(=O)c3cccc(Cl)c3)ccc2C)s1 CHEMBL462130 IC50 7.0 nM
Cc1ncc(NC(=O)c2cc(NC(=O)c3cccc(C(F)(F)F)c3)ccc2Cl)s1 CHEMBL462132 IC50 7.0 nM
CCN1CCCC(O)(c2cccc(Nc3ncc4c(=O)c(C(=O)NOC)cn(-c5cnc6c(c5)CCC6)c4n3)c2)C1 CHEMBL450914 IC50 7.0 nM
COc1cc2c(Nc3ccc(F)c(Cl)c3)c(C(N)=O)cnc2cc1OCCCN1CCN(C)CC1 CHEMBL481231 IC50 7.0 nM
COc1cc2ncc(C(N)=O)c(Nc3cccc(Cl)c3Cl)c2cc1NCCN1CCCCC1 CHEMBL481595 IC50 7.0 nM
COc1cc2ncc(C(N)=O)c(Nc3ccc(F)cc3F)c2cc1NCCN(C)C CHEMBL479445 IC50 7.0 nM
COc1cc2ncc(C(N)=O)c(Nc3ccc(F)cc3F)c2cc1NCCN1CCOCC1 CHEMBL479446 IC50 7.0 nM
COc1ccc(COc2ccc(Cn3cnc4cc(N5CC6(CCNCC6)C5)cnc43)cc2OC)cn1 CHEMBL3673459 IC50 7.0 nM
COc1ccc(COc2ccc(Cn3cnc4cc(-c5noc(C6CCNCC6)n5)cnc43)cc2OC)cn1 CHEMBL3673464 IC50 7.0 nM
COc1ccc(COc2ccc(Cn3cnc4cc(-n5cc(C(C)(C)N)nn5)cnc43)cc2OC)cn1 CHEMBL3673467 IC50 7.0 nM
COc1ccc(COc2ccc(Cn3c(N)nc4cc(-c5ccccc5)cnc43)cc2OC)cn1 CHEMBL3673481 IC50 7.0 nM
COc1cc(Cn2c(N)nc3cc(-c4cnn(C)c4)cnc32)ccc1OCc1csc(C(F)(F)F)n1 CHEMBL3678287 IC50 7.0 nM
Cn1cc(-c2cc(Oc3cc(F)c(NC(=O)N4CCN(C5CCOCC5)C4=O)cc3F)ccn2)cn1 CHEMBL3948615 IC50 7.0 nM
CCC(=O)N1CC[C@H](N2C(=O)N(c3cc(OC)ccc3F)Cc3cnc(Nc4ccc(N5C[C@H]6CN(C)C[C@H]6C5)c(C)c4)nc32)C1 CHEMBL4096988 IC50 7.0 nM
Nc1ncnc2c(C(=O)Nc3cccc4c3c(Br)nn4Cc3ccncc3)csc12 CHEMBL4462286 IC50 7.0 nM
N#Cc1c[nH]c(C(=O)Nc2ccc(-c3cccc[n+]3[O-])cc2C2=CCCCC2)n1 CHEMBL1172116 IC50 7.1 nM
CN(CCS(C)(=O)=O)C(C)(C)c1ccc(NC(=O)c2ncc(C#N)[nH]2)c(C2=CCC(C)(C)CC2)c1 CHEMBL3086323 IC50 7.2 nM
CCC(=O)N1CC[C@H](N2C(=O)N(c3cc(OC)ccc3F)Cc3cnc(Nc4ccc(N5CCN(C)C(C)C5)c(C)c4)nc32)C1 CHEMBL4093535 IC50 7.2 nM
Cc1ccc(NC(=O)c2ccc(Cl)cc2)cc1C#Cc1cc(-c2cnn(C)c2)cnc1N CHEMBL4449943 IC50 7.2 nM
CN(Cc1ccccn1)c1ncnc2[nH]c(-c3ccc(CO)cc3)nc12 CHEMBL5428255 IC50 7.2 nM
Cc1cccc(CN(C)c2ncnc3[nH]c(-c4ccc(CCC(=O)O)cc4)cc23)c1 CHEMBL5418087 Kd 7.2 nM
Cc1nc(NC(=O)NC(=O)C2CCOC2)ccc1Oc1ccnc(-c2cnn(C)c2)c1 CHEMBL5191635 IC50 7.3 nM
Cc1ccc(NC(=O)c2ccc(CN3CCN(C)CC3)cc2)cc1Nc1nc(-c2cccnc2)cs1 CHEMBL1908391 Kd 7.6 nM
Cc1[nH]c(/C=C2\C(=O)Nc3cc(NC(=O)Nc4cc(C(C)(C)C)on4)ccc32)c(C)c1NC(=O)CN1CCOCC1 CHEMBL5073700 IC50 7.6 nM
COC1(C(=O)NC(=O)Nc2ccc(Oc3ccnc(-c4cnn(C)c4)c3)c(C)n2)CC1 CHEMBL5176187 IC50 7.7 nM
COC(=O)CCCCc1ccc(-c2cc3c(N(C)Cc4cccc(C)c4)ncnc3[nH]2)cc1 CHEMBL5416379 IC50 7.7 nM
C[C@@H]1CN(S(=O)(=O)Cc2ccc(NC(=O)c3nc(C#N)c[nH]3)c(C3=CCCCC3)c2)C[C@H](C)N1 CHEMBL3660764 IC50 7.74 nM
CCC(=O)N1CC[C@H](N2C(=O)N(c3cc(OC)ccc3F)Cc3cnc(Nc4ccc(N5C[C@@H](C)N(C)[C@@H](C)C5)c(C)c4)nc32)C1 CHEMBL4103893 IC50 7.8 nM
Cc1ccc(Nc2nccc(N(C)c3ccc4c(C)n(C)nc4c3)n2)cc1S(N)(=O)=O CHEMBL477772 Kd 7.9 nM
CNC1CC2OC(C)(C1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 CHEMBL1980995 pKi 7.943 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(C#CCN5CCOCC5)cnc(N)c34)cc2)c1 CHEMBL1982465 pKi 7.943 nM
Cc1cccc(NC(=O)Nc2ccc(-c3csc4c(C#CC(C)(C)N)cnc(N)c34)cc2)c1 CHEMBL1979577 pKi 7.943 nM
Cc1ccc(NC(=O)Nc2ccc(-c3csc4c(-c5cnn(C)c5)cnc(N)c34)cc2)cc1 CHEMBL1982466 pKi 7.943 nM
CN1CCN(Cc2ccc3c(c2)Cc2c(-c4csc(C#CCOc5ccccc5)c4)n[nH]c2-3)CC1 CHEMBL390156 IC50 8.0 nM
Cc1ccc(Nc2c(C(N)=O)cnc3cc(-c4ccc(S(C)(=O)=O)cc4)ccc23)cc1C CHEMBL250571 IC50 8.0 nM
NC(=O)c1cn(-c2ccc3c(c2)CCC3)c2nc(Nc3ccc(CCN4CCOCC4)cc3)ncc2c1=O CHEMBL404188 IC50 8.0 nM
NC(=O)c1cn(-c2ccc3c(c2)CCC3)c2nc(Nc3ccc(C4CCNCC4)cc3)ncc2c1=O CHEMBL257528 IC50 8.0 nM
CN1CCN(c2cccc(Nc3ncc4c(=O)c(C(N)=O)cn(-c5ccc6c(c5)CCC6)c4n3)c2)CC1 CHEMBL255584 IC50 8.0 nM
N#Cc1cnc(C(=O)Nc2ccc(C3CCNCC3)cc2C2=CCCC2)[nH]1 CHEMBL256950 IC50 8.0 nM
Cc1cc(C)cc(C(=O)Nc2ccc(Cl)c(C(=O)Nc3cccnc3)c2)c1 CHEMBL459470 IC50 8.0 nM
CN1CCN(c2ccc3ncc(C(N)=O)c(Nc4cccc(Cl)c4Cl)c3c2)CC1 CHEMBL480457 IC50 8.0 nM
COCCOc1cc2ncnc(Oc3cnn(CC(=O)Nc4cccc(OC)c4)c3)c2cc1OC CHEMBL1940109 IC50 8.0 nM
CC1(C)CC=C(c2cc(C(C)(C)CN3CCOCC3)ccc2NC(=O)c2ncc(C#N)[nH]2)CC1 CHEMBL3085970 IC50 8.0 nM
COc1ccc(COc2ccc(Cn3cnc4cc(N5CCOCC5)cnc43)cc2OC)cn1 CHEMBL3673456 IC50 8.0 nM
COc1cc(Cn2c(N)nc3cc(-c4cnn(C)c4)cnc32)ccc1OCc1ccc(OC(F)(F)F)cc1 CHEMBL3678283 IC50 8.0 nM
CCN1CCN(C(=O)Nc2ccc(Oc3ccnc(-c4cnn(C)c4)c3)c(C)n2)C1=O CHEMBL3936132 IC50 8.0 nM
CN(C)C(=O)Nc1cc(Oc2cc(F)c(NC(=O)N3CCN(C4CCOCC4)C3=O)cc2Cl)ccn1 CHEMBL3974611 IC50 8.0 nM
CC(C)(C(=O)O)c1ccc(NC(=O)c2nc(C#N)c[nH]2)c(C2=CCCCC2)c1 CHEMBL3660760 IC50 8.0 nM
COc1cc(NC(=O)c2ccc(C)c(C#Cc3cc(-c4cnn(C)c4)cnc3N)c2)cc(OC)c1OC CHEMBL4854948 IC50 8.0 nM
C=CC(=O)N1CCN(CCCn2c(=O)c(-c3c(Cl)c(OC)cc(OC)c3Cl)cc3cnc(NC)nc32)CC1 CHEMBL4068509 IC50 8.1 nM
CNC(=O)c1cnc(N)c(C#Cc2cc(C(=O)Nc3cc(OC)cc(OC)c3)ccc2C)c1 CHEMBL4583617 IC50 8.1 nM
O=C(Nc1ccc(CCN2CCOCC2)cc1C1=CCCCC1)c1ncc(Cl)[nH]1 CHEMBL3912812 IC50 8.2 nM
O=C(Nc1ccc(CCN2CCOCC2)cc1C1=CCCCC1)c1ncc(Cl)[nH]1 CHEMBL4284579 IC50 8.2 nM
Cc1[nH]c(/C=C2\C(=O)Nc3cc(NC(=O)Nc4cc(C(C)(C)C)on4)ccc32)c(C)c1NC(=O)[C@@H]1CCCN1 CHEMBL5083344 IC50 8.2 nM
CN(C)c1ccc2c(Oc3ccc(NC(=O)NCc4ccc(F)cc4)cc3)ncnc2c1 CHEMBL4851635 IC50 8.3 nM
OCc1ccc(-c2cc3c(NCc4ccccc4)ncnc3[nH]2)cc1 CHEMBL5397557 IC50 8.3 nM
Cc1[nH]c(/C=C2\C(=O)Nc3cc(NC(=O)Nc4cc(C(C)(C)C)on4)ccc32)c(C)c1NC(=O)CCN1CCOCC1 CHEMBL5087148 IC50 8.4 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(NC(=O)c3cc4ccccc4cn3)cc2)no1 CHEMBL1081509 Kd 8.5 nM
CC(C)(NC(=O)C(N)=O)c1ccc(NC(=O)c2nc(C#N)c[nH]2)c(C2=CCCCC2)c1 CHEMBL3660757 IC50 8.6 nM
COc1cc(/C=N/c2cnc(Nc3ccc(N4CCOCC4)cc3)nc2Oc2cccc(OC)c2)cc(OC)c1 CHEMBL4172190 IC50 8.6 nM
Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12 CHEMBL1171837 IC50 8.6 nM
Cc1cccc(NC(C)(C)c2ccc(NC(=O)c3ncc(C#N)[nH]3)c(C3=CCC(C)(C)CC3)c2)n1 CHEMBL3660795 IC50 8.8 nM
CN(Cc1ccc(F)cc1)c1ncnc2[nH]c(-c3ccc(CO)cc3)nc12 CHEMBL5400254 IC50 8.8 nM
CCc1ccc(COc2ccc(C3CN(C(=O)c4cc(OCCN5C[C@@H](O)[C@H](O)C5)ccn4)C3)cc2OC)cc1 CHEMBL4539279 IC50 8.9 nM
COCCOCC#Cc1cc(-c2n[nH]c3c2Cc2ccc(Cn4cncn4)cc2-3)cs1 CHEMBL223971 IC50 9.0 nM
COc1cccc(C(=O)Nc2ccc(Cl)c(C(=O)Nc3cccnc3)c2)c1 CHEMBL461952 IC50 9.0 nM
COc1cc2ncc(C(N)=O)c(Nc3ccccc3F)c2cc1OC CHEMBL442591 IC50 9.0 nM
COc1cc2ncc(C(N)=O)c(Nc3ccc(Cl)c(Cl)c3)c2cc1OC CHEMBL480630 IC50 9.0 nM
C[C@H](Nc1cncc(Cl)n1)c1cccc(NC(=O)c2ccc(F)c(Cl)c2)c1 CHEMBL474489 IC50 9.0 nM
Cc1ccc(C(=O)Nc2cccc([C@H](C)Nc3cncc(Cl)n3)c2)cc1 CHEMBL472864 IC50 9.0 nM
COc1ccc2c(Oc3ccc(CC(=O)Nc4cc(C)cc(CN(C)C)c4)c(OC)c3)ccnc2c1 CHEMBL2023494 IC50 9.0 nM
COc1cc2ncnc(Oc3cccc(NC(=O)Nc4cc(C(C)(C)C(F)(F)F)on4)c3)c2cc1OC CHEMBL2029988 Kd 9.0 nM
COc1ccc(COc2ccc(Cn3c(N)nc4cc(-c5ccc(F)cc5)cnc43)cc2OC)cn1 CHEMBL3673482 IC50 9.0 nM
Cc1ccc(NC(=O)c2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1NC(=O)c1cccc(-c2cncnc2)c1 CHEMBL4100838 IC50 9.0 nM
Nc1ncnc2c(C(=O)Nc3cccc4c3c(Br)nn4Cc3ccccn3)csc12 CHEMBL4448250 IC50 9.0 nM
Cc1cccc(Cn2nc(I)c3c(NC(=O)c4csc5c(N)ncnc45)cccc32)n1 CHEMBL4552261 IC50 9.0 nM
CCc1nn(Cc2cccc(C)n2)c2cccc(NC(=O)c3csc4c(N)ncnc34)c12 CHEMBL4436822 IC50 9.0 nM
COc1cc(-n2c3c(c4ncnc(N)c42)CCC3)ccc1NC(=O)Cc1ccc(C(F)(F)F)nn1 CHEMBL4483817 IC50 9.0 nM
Nc1ncnc2c3c(n(-c4ccc(CC(=O)Nc5ccc(Cl)c(C(F)(F)F)c5)cc4)c12)CCC3 CHEMBL4442369 IC50 9.0 nM
COc1cc(OCc2ccnc(Nc3ccn(C)n3)n2)cc2sc(N[C@H]3CCCC[C@@H]3O)nc12 CHEMBL4787609 IC50 9.0 nM
CC(C)(C)c1cc(NC(=O)Nc2ccc(Nc3ncnc4c3OCCCN4)cc2)no1 CHEMBL4793380 IC50 9.0 nM
CCc1ccc(COc2ccc(C3CN(C(=O)c4cc(OCCO)ccn4)C3)cc2OC)cc1 CHEMBL4437645 IC50 9.1 nM
COC(C)(C)C(=O)NC(=O)Nc1ccc(Oc2ccnc(-c3cnc(C)s3)c2)c(C)n1 CHEMBL5177523 IC50 9.1 nM
CC1(C)CC=C(c2cc(C(C)(C)N3CCSCC3)ccc2NC(=O)c2ncc(C#N)[nH]2)CC1 CHEMBL3660761 IC50 9.3 nM
CN(C)S(=O)(=O)CCc1ccc(NC(=O)c2ncc(C#N)[nH]2)c(C2=CCCCC2)c1 CHEMBL3660765 IC50 9.4 nM
Cc1nc(NC(=O)NC(=O)Cc2ccc(F)cc2)ccc1Oc1ccnc(-c2cnn(C)c2)c1 CHEMBL5197530 IC50 9.4 nM
Cc1ccc(NC(=O)c2cc(N3CCN(C)CC3)cc(C(F)(F)F)c2)cc1NC(=O)c1cnoc1C CHEMBL3616960 IC50 9.95 nM